NLGN4Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.46898069
2presynaptic membrane organization (GO:0097090)4.97968250
3pyrimidine nucleobase catabolic process (GO:0006208)4.53356751
4postsynaptic membrane organization (GO:0001941)4.09970422
5gamma-aminobutyric acid transport (GO:0015812)4.05019514
6* neuron cell-cell adhesion (GO:0007158)3.73392472
7* vocalization behavior (GO:0071625)3.72599063
8neuronal action potential propagation (GO:0019227)3.71029148
9behavioral response to nicotine (GO:0035095)3.62657520
10nonmotile primary cilium assembly (GO:0035058)3.55055750
11nucleobase catabolic process (GO:0046113)3.52991121
12C4-dicarboxylate transport (GO:0015740)3.46639519
13limb bud formation (GO:0060174)3.29916222
14retinal cone cell development (GO:0046549)3.21855831
15protein localization to synapse (GO:0035418)3.20009609
16axonal fasciculation (GO:0007413)3.15032547
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.13308171
18water-soluble vitamin biosynthetic process (GO:0042364)3.10276407
19neuron recognition (GO:0008038)3.07036047
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00929897
21kidney morphogenesis (GO:0060993)3.00575323
22ionotropic glutamate receptor signaling pathway (GO:0035235)2.92572294
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88069066
24neurotransmitter-gated ion channel clustering (GO:0072578)2.84932650
25* synapse assembly (GO:0007416)2.81759375
26epithelial cilium movement (GO:0003351)2.80785154
27response to pheromone (GO:0019236)2.77835701
28somite development (GO:0061053)2.74844259
29synaptic transmission, glutamatergic (GO:0035249)2.73829447
30mechanosensory behavior (GO:0007638)2.73370467
31retinal ganglion cell axon guidance (GO:0031290)2.72347599
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71225493
33regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.70966121
34glutamate receptor signaling pathway (GO:0007215)2.70394722
35DNA double-strand break processing (GO:0000729)2.66109840
36otic vesicle formation (GO:0030916)2.65568056
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63946668
38negative regulation of translation, ncRNA-mediated (GO:0040033)2.63946668
39regulation of translation, ncRNA-mediated (GO:0045974)2.63946668
40DNA damage response, detection of DNA damage (GO:0042769)2.62001042
41positive regulation of synapse assembly (GO:0051965)2.60276262
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57669713
43regulation of gene silencing by RNA (GO:0060966)2.57426788
44regulation of posttranscriptional gene silencing (GO:0060147)2.57426788
45regulation of gene silencing by miRNA (GO:0060964)2.57426788
46transmission of nerve impulse (GO:0019226)2.56849406
47inner ear receptor cell development (GO:0060119)2.55704287
48olfactory bulb development (GO:0021772)2.51303390
49regulation of non-canonical Wnt signaling pathway (GO:2000050)2.50555137
50short-term memory (GO:0007614)2.49244953
51auditory behavior (GO:0031223)2.47330404
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47315009
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46954769
54negative regulation of axon guidance (GO:1902668)2.46150192
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45920180
56chaperone-mediated protein transport (GO:0072321)2.44992441
57neuron-neuron synaptic transmission (GO:0007270)2.44228737
58negative regulation of telomere maintenance (GO:0032205)2.42688842
59atrial cardiac muscle cell action potential (GO:0086014)2.41299042
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39147259
61negative regulation of axon extension (GO:0030517)2.37244744
62appendage development (GO:0048736)2.37080058
63limb development (GO:0060173)2.37080058
64lateral sprouting from an epithelium (GO:0060601)2.37006528
65spinal cord motor neuron differentiation (GO:0021522)2.35749174
66protein polyglutamylation (GO:0018095)2.35346045
67neuron fate determination (GO:0048664)2.34979477
68regulation of synapse assembly (GO:0051963)2.34836186
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33770390
70intraciliary transport (GO:0042073)2.31830268
71axon extension involved in axon guidance (GO:0048846)2.31623622
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.31623622
73regulation of development, heterochronic (GO:0040034)2.31563201
74regulation of telomere maintenance (GO:0032204)2.31004186
75regulation of cell fate specification (GO:0042659)2.30999683
76regulation of timing of cell differentiation (GO:0048505)2.30730544
77cilium morphogenesis (GO:0060271)2.30640868
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30426008
79startle response (GO:0001964)2.30378997
80spinal cord development (GO:0021510)2.28750808
81nephron epithelium morphogenesis (GO:0072088)2.28647359
82nephron tubule morphogenesis (GO:0072078)2.28647359
83cilium movement (GO:0003341)2.28365400
84hindbrain development (GO:0030902)2.27809621
85cellular response to cholesterol (GO:0071397)2.26954579
86* synapse organization (GO:0050808)2.26280329
87head development (GO:0060322)2.25083364
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.24377398
89neurotransmitter uptake (GO:0001504)2.22741119
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.22576379
91negative chemotaxis (GO:0050919)2.22171478
92renal tubule morphogenesis (GO:0061333)2.21762344
93regulation of synapse structural plasticity (GO:0051823)2.21749545
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.21383400
95cilium organization (GO:0044782)2.20334571
96substrate-independent telencephalic tangential migration (GO:0021826)2.19975309
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.19975309
98cilium assembly (GO:0042384)2.16505659
99smoothened signaling pathway (GO:0007224)2.16374581
100artery development (GO:0060840)2.16360333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.87812714
2GBX2_23144817_ChIP-Seq_PC3_Human3.37750623
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25206929
4ZNF274_21170338_ChIP-Seq_K562_Hela2.84381526
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80006033
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48263012
7IGF1R_20145208_ChIP-Seq_DFB_Human2.33780772
8TAF15_26573619_Chip-Seq_HEK293_Human2.32186222
9P300_19829295_ChIP-Seq_ESCs_Human2.28554135
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27638387
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27325860
12FUS_26573619_Chip-Seq_HEK293_Human2.21334761
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18213294
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11832727
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11737846
16VDR_22108803_ChIP-Seq_LS180_Human2.05182912
17EWS_26573619_Chip-Seq_HEK293_Human1.97527957
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92923623
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92723779
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.92713864
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.89594886
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87894037
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79360709
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74756184
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72076498
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.71615049
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71215195
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70541513
29SMAD4_21799915_ChIP-Seq_A2780_Human1.68810462
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62838981
31REST_21632747_ChIP-Seq_MESCs_Mouse1.58938378
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.56946589
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.54859424
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54432300
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53078138
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52485572
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50190686
38RNF2_27304074_Chip-Seq_NSC_Mouse1.49622029
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.49268763
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48751228
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47826232
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47238733
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42851163
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40711092
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.40386273
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37705546
47STAT3_23295773_ChIP-Seq_U87_Human1.37017637
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35582156
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35582156
50AR_21572438_ChIP-Seq_LNCaP_Human1.35391747
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34698793
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34591597
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33475058
54AR_25329375_ChIP-Seq_VCAP_Human1.33354700
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33150777
56BCAT_22108803_ChIP-Seq_LS180_Human1.31747068
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29431906
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29399968
59CBP_20019798_ChIP-Seq_JUKART_Human1.28276707
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28276707
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.27104833
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26491516
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26049877
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25968756
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24872205
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21859893
67RUNX2_22187159_ChIP-Seq_PCA_Human1.21111752
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.20992620
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20514499
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19957763
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19523569
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19369883
73TCF4_23295773_ChIP-Seq_U87_Human1.19267451
74TCF4_22108803_ChIP-Seq_LS180_Human1.17549033
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17411627
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17411627
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15982997
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15916884
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13638340
80IRF1_19129219_ChIP-ChIP_H3396_Human1.11944316
81ER_23166858_ChIP-Seq_MCF-7_Human1.11856505
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11387899
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11323823
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.11162339
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09778852
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08906065
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08808355
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08578555
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.07828314
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.07775569
91SOX9_26525672_Chip-Seq_HEART_Mouse1.06883646
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05220893
93JUN_21703547_ChIP-Seq_K562_Human1.04664096
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03523801
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02888817
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.02045999
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.01262249
98MYC_18940864_ChIP-ChIP_HL60_Human1.00378695
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.98952397
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98731249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting2.85536781
2MP0006292_abnormal_olfactory_placode2.77311674
3MP0004859_abnormal_synaptic_plasticity2.63392148
4MP0003136_yellow_coat_color2.43211679
5MP0003880_abnormal_central_pattern2.37293104
6MP0001984_abnormal_olfaction2.36500115
7MP0000778_abnormal_nervous_system2.23188988
8MP0004270_analgesia2.10688365
9MP0001529_abnormal_vocalization2.08562907
10MP0008877_abnormal_DNA_methylation2.08114798
11MP0002102_abnormal_ear_morphology2.07815535
12MP0002736_abnormal_nociception_after2.02001001
13MP0003787_abnormal_imprinting1.93482554
14MP0001486_abnormal_startle_reflex1.91046751
15MP0003121_genomic_imprinting1.87946390
16MP0001293_anophthalmia1.87078849
17MP0001968_abnormal_touch/_nociception1.84256073
18MP0004133_heterotaxia1.82677680
19MP0002272_abnormal_nervous_system1.82029291
20MP0003635_abnormal_synaptic_transmissio1.81516619
21MP0009745_abnormal_behavioral_response1.80538652
22MP0004885_abnormal_endolymph1.77512302
23MP0002734_abnormal_mechanical_nocicepti1.77164084
24MP0009046_muscle_twitch1.72918795
25MP0006276_abnormal_autonomic_nervous1.67077100
26MP0003941_abnormal_skin_development1.63586787
27MP0002572_abnormal_emotion/affect_behav1.58519835
28MP0002938_white_spotting1.58462781
29MP0002064_seizures1.57820002
30MP0003890_abnormal_embryonic-extraembry1.57656355
31MP0002063_abnormal_learning/memory/cond1.57410945
32MP0001299_abnormal_eye_distance/1.57249239
33MP0001188_hyperpigmentation1.56822628
34MP0005423_abnormal_somatic_nervous1.55764665
35MP0005551_abnormal_eye_electrophysiolog1.52467710
36MP0002638_abnormal_pupillary_reflex1.52334881
37MP0002735_abnormal_chemical_nociception1.46798810
38MP0006072_abnormal_retinal_apoptosis1.44783505
39MP0003937_abnormal_limbs/digits/tail_de1.43786256
40MP0000049_abnormal_middle_ear1.42438702
41MP0003283_abnormal_digestive_organ1.40068869
42MP0002751_abnormal_autonomic_nervous1.32842847
43MP0002233_abnormal_nose_morphology1.32667743
44MP0002557_abnormal_social/conspecific_i1.31558566
45MP0003119_abnormal_digestive_system1.28657190
46MP0002653_abnormal_ependyma_morphology1.27980123
47MP0000955_abnormal_spinal_cord1.27050691
48MP0010030_abnormal_orbit_morphology1.26586377
49MP0005499_abnormal_olfactory_system1.25505313
50MP0005394_taste/olfaction_phenotype1.25505313
51MP0001177_atelectasis1.25076149
52MP0002184_abnormal_innervation1.25008512
53MP0003938_abnormal_ear_development1.24386908
54MP0000631_abnormal_neuroendocrine_gland1.22328146
55MP0002067_abnormal_sensory_capabilities1.21657763
56MP0002254_reproductive_system_inflammat1.21091873
57MP0008789_abnormal_olfactory_epithelium1.20743104
58MP0003011_delayed_dark_adaptation1.20742616
59MP0005084_abnormal_gallbladder_morpholo1.20195439
60MP0001485_abnormal_pinna_reflex1.18999858
61MP0001970_abnormal_pain_threshold1.17625249
62MP0005253_abnormal_eye_physiology1.16766627
63MP0004142_abnormal_muscle_tone1.16561707
64MP0000566_synostosis1.13909243
65MP0001286_abnormal_eye_development1.13895499
66MP0003755_abnormal_palate_morphology1.13636040
67MP0004742_abnormal_vestibular_system1.12685112
68MP0002752_abnormal_somatic_nervous1.11215074
69MP0010386_abnormal_urinary_bladder1.09289990
70MP0000026_abnormal_inner_ear1.09122747
71MP0002697_abnormal_eye_size1.08646324
72MP0000569_abnormal_digit_pigmentation1.08027579
73MP0002882_abnormal_neuron_morphology1.04975379
74MP0003861_abnormal_nervous_system1.04513369
75MP0003567_abnormal_fetal_cardiomyocyte1.01830860
76MP0002282_abnormal_trachea_morphology1.00301041
77MP0002152_abnormal_brain_morphology1.00293208
78MP0009250_abnormal_appendicular_skeleto0.97616273
79MP0003878_abnormal_ear_physiology0.96905416
80MP0005377_hearing/vestibular/ear_phenot0.96905416
81MP0005195_abnormal_posterior_eye0.95573641
82MP0002733_abnormal_thermal_nociception0.95232599
83MP0004924_abnormal_behavior0.92050475
84MP0005386_behavior/neurological_phenoty0.92050475
85MP0001502_abnormal_circadian_rhythm0.91080338
86MP0002928_abnormal_bile_duct0.90949659
87MP0001963_abnormal_hearing_physiology0.90502441
88MP0005391_vision/eye_phenotype0.90124226
89MP0001905_abnormal_dopamine_level0.89355544
90MP0005187_abnormal_penis_morphology0.88510605
91MP0001501_abnormal_sleep_pattern0.85093393
92MP0005646_abnormal_pituitary_gland0.83065119
93MP0001986_abnormal_taste_sensitivity0.82517733
94MP0003942_abnormal_urinary_system0.81128808
95MP0002066_abnormal_motor_capabilities/c0.79819069
96MP0001440_abnormal_grooming_behavior0.78455296
97MP0004811_abnormal_neuron_physiology0.75346164
98MP0002909_abnormal_adrenal_gland0.74901582
99MP0002234_abnormal_pharynx_morphology0.74809450
100MP0002116_abnormal_craniofacial_bone0.74742146

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.67568023
2Septo-optic dysplasia (HP:0100842)3.47405920
3Pancreatic fibrosis (HP:0100732)3.44322174
4Abnormality of midbrain morphology (HP:0002418)3.35957572
5Molar tooth sign on MRI (HP:0002419)3.35957572
6Abnormality of the labia minora (HP:0012880)3.31645217
7Nephronophthisis (HP:0000090)2.92050201
8Pancreatic cysts (HP:0001737)2.90844383
9Atonic seizures (HP:0010819)2.90080718
10Medial flaring of the eyebrow (HP:0010747)2.76760626
11Gait imbalance (HP:0002141)2.75857253
12Focal seizures (HP:0007359)2.74342536
13Focal motor seizures (HP:0011153)2.71727249
14Limb dystonia (HP:0002451)2.71536067
15Febrile seizures (HP:0002373)2.70764859
16Colon cancer (HP:0003003)2.70374862
17Genital tract atresia (HP:0001827)2.67739083
18Hyperventilation (HP:0002883)2.61342223
19Vaginal atresia (HP:0000148)2.59017094
20Congenital primary aphakia (HP:0007707)2.50911277
21Myokymia (HP:0002411)2.50080719
22Optic nerve hypoplasia (HP:0000609)2.49417057
23Sclerocornea (HP:0000647)2.46618364
24Bifid tongue (HP:0010297)2.43889052
25Nephrogenic diabetes insipidus (HP:0009806)2.43555442
26Polyphagia (HP:0002591)2.38493940
27Broad-based gait (HP:0002136)2.30331857
28Dialeptic seizures (HP:0011146)2.29381535
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28696943
30Hemiparesis (HP:0001269)2.28039784
31Abnormality of the renal medulla (HP:0100957)2.27309552
32Chronic hepatic failure (HP:0100626)2.25540407
33Increased corneal curvature (HP:0100692)2.25370532
34Keratoconus (HP:0000563)2.25370532
35Anophthalmia (HP:0000528)2.24451089
36Methylmalonic acidemia (HP:0002912)2.23566513
37Anencephaly (HP:0002323)2.21008596
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.19526262
39Epileptic encephalopathy (HP:0200134)2.19390282
40Drooling (HP:0002307)2.14002772
41Split foot (HP:0001839)2.12092742
42Abnormal biliary tract physiology (HP:0012439)2.12040092
43Bile duct proliferation (HP:0001408)2.12040092
44Renal hypoplasia (HP:0000089)2.11839938
45Cystic liver disease (HP:0006706)2.11434266
46Hyperglycinemia (HP:0002154)2.07430615
47Postaxial hand polydactyly (HP:0001162)2.05583060
48Intestinal atresia (HP:0011100)2.05265134
49Hypoplastic pelvis (HP:0008839)2.04970051
50Bilateral microphthalmos (HP:0007633)2.04518805
51Progressive macrocephaly (HP:0004481)2.01329325
52Generalized tonic-clonic seizures (HP:0002069)2.00515514
53Acute necrotizing encephalopathy (HP:0006965)1.98919443
54Lissencephaly (HP:0001339)1.96809957
55Hepatoblastoma (HP:0002884)1.96314893
56Specific learning disability (HP:0001328)1.95354009
57Progressive cerebellar ataxia (HP:0002073)1.94580195
58Labial hypoplasia (HP:0000066)1.93786652
59Pendular nystagmus (HP:0012043)1.92858376
60Cutaneous finger syndactyly (HP:0010554)1.92711253
61Abolished electroretinogram (ERG) (HP:0000550)1.92083197
62Narrow forehead (HP:0000341)1.88306388
63Scrotal hypoplasia (HP:0000046)1.88046396
64Congenital stationary night blindness (HP:0007642)1.87138307
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.85764599
66Hypothermia (HP:0002045)1.83663655
67Absence seizures (HP:0002121)1.83554736
68Excessive salivation (HP:0003781)1.83510320
69Occipital encephalocele (HP:0002085)1.82775308
70Postaxial foot polydactyly (HP:0001830)1.81644295
71Type II lissencephaly (HP:0007260)1.81298137
72Absent septum pellucidum (HP:0001331)1.78726210
73Hypoplastic female external genitalia (HP:0012815)1.78478255
74Inability to walk (HP:0002540)1.76548652
75Abnormal hair whorl (HP:0010721)1.76346717
76Broad foot (HP:0001769)1.76320275
77Male pseudohermaphroditism (HP:0000037)1.75780653
78Gastrointestinal atresia (HP:0002589)1.74971859
79Supernumerary spleens (HP:0009799)1.73981697
80Poor coordination (HP:0002370)1.73612554
81Oligodactyly (hands) (HP:0001180)1.70926968
82Rib fusion (HP:0000902)1.70705918
83Small hand (HP:0200055)1.70284457
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.69515830
85Action tremor (HP:0002345)1.68696606
86Micropenis (HP:0000054)1.68056434
87Preaxial hand polydactyly (HP:0001177)1.67268521
88Acute encephalopathy (HP:0006846)1.66062246
89Maternal diabetes (HP:0009800)1.64076179
90Dandy-Walker malformation (HP:0001305)1.64020185
91Cutaneous syndactyly (HP:0012725)1.62411799
92Cortical dysplasia (HP:0002539)1.59978418
93Decreased muscle mass (HP:0003199)1.59382738
94Progressive inability to walk (HP:0002505)1.58702193
95Protruding tongue (HP:0010808)1.58443879
96Short foot (HP:0001773)1.57856330
97Chorioretinal coloboma (HP:0000567)1.57753543
98Preaxial foot polydactyly (HP:0001841)1.57407700
99Short tibia (HP:0005736)1.56971086
100Cerebellar dysplasia (HP:0007033)1.56803015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.70982853
2WNK33.52885664
3MARK13.17708274
4TNIK2.53996924
5PNCK2.49823729
6MAP3K122.40983651
7FRK2.38586071
8MAP3K42.36106384
9MKNK22.23668038
10BCR2.10190504
11BMPR1B2.09553368
12DYRK21.99480516
13NTRK21.82902194
14TRIM281.76717908
15EPHA41.70098035
16MAPK131.65205772
17MKNK11.61979933
18CSNK1G21.59150709
19STK38L1.56395908
20MAP2K71.54450172
21GRK11.51616154
22MAP4K21.50829714
23TSSK61.49558888
24CSNK1G11.47086461
25ZAK1.46739644
26PLK31.44510256
27TIE11.44202462
28PINK11.41371425
29ADRBK21.37210768
30NTRK31.31769605
31PLK21.30804461
32STK161.30748700
33PRKCG1.29581969
34EPHB21.28652258
35FGFR21.24868057
36PAK31.23945667
37CSNK1G31.23814933
38MAPK151.21980717
39VRK11.18198215
40INSRR1.13653284
41CSNK1A1L1.09978067
42MAP2K41.09929348
43PRKCE1.03679636
44NUAK11.02755484
45DYRK30.93449494
46ACVR1B0.87303709
47DYRK1A0.86781116
48MINK10.84513009
49ERBB30.83253206
50CDC70.81689172
51TAF10.78160063
52NTRK10.76578510
53VRK20.76243995
54CAMK2A0.73649359
55WNK40.72393577
56BUB10.70744826
57DAPK20.70070849
58TTK0.66973023
59PAK60.65806424
60TGFBR10.63874403
61SRPK10.63277551
62WEE10.62951477
63LIMK10.61718614
64UHMK10.60271871
65SGK2230.60123190
66SGK4940.60123190
67OXSR10.59619443
68CDK50.59321983
69CDK30.58809249
70STK390.57381549
71PLK10.54036230
72MAP3K90.54008148
73PIK3CA0.52837583
74KSR10.52722930
75PRKCZ0.50210918
76FGFR10.49866074
77SGK20.49492575
78CAMK2B0.49461075
79NME10.49204053
80CSNK1D0.46915556
81CSNK1E0.46176463
82PKN10.46111202
83BRSK20.45294841
84BCKDK0.45252404
85TYRO30.45109156
86CSNK1A10.44044849
87PRKG10.43983719
88PRKACA0.43561808
89CAMK10.42931037
90PHKG10.41837722
91PHKG20.41837722
92PRKDC0.39624617
93CAMK1G0.39246779
94PLK40.38722894
95ROCK10.38160768
96STK110.37427273
97AKT30.36885165
98CHEK20.34720176
99MAPKAPK50.34713285
100CAMK2D0.34376230

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67366044
2Protein export_Homo sapiens_hsa030603.00766901
3Oxidative phosphorylation_Homo sapiens_hsa001902.23403448
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17460534
5GABAergic synapse_Homo sapiens_hsa047272.03656345
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97445679
7Steroid biosynthesis_Homo sapiens_hsa001001.94860098
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92250755
9Parkinsons disease_Homo sapiens_hsa050121.79908430
10Phototransduction_Homo sapiens_hsa047441.79831720
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73241848
12Glutamatergic synapse_Homo sapiens_hsa047241.71458669
13Butanoate metabolism_Homo sapiens_hsa006501.69360977
14Morphine addiction_Homo sapiens_hsa050321.67435073
15Hedgehog signaling pathway_Homo sapiens_hsa043401.66774412
16Taste transduction_Homo sapiens_hsa047421.59385599
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54604981
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52656962
19Cardiac muscle contraction_Homo sapiens_hsa042601.52571268
20Basal cell carcinoma_Homo sapiens_hsa052171.48631332
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48508717
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46493311
23Propanoate metabolism_Homo sapiens_hsa006401.43776370
24Circadian entrainment_Homo sapiens_hsa047131.41753575
25Nitrogen metabolism_Homo sapiens_hsa009101.38261637
26Huntingtons disease_Homo sapiens_hsa050161.32580004
27RNA polymerase_Homo sapiens_hsa030201.32096408
28Basal transcription factors_Homo sapiens_hsa030221.28399260
29Alzheimers disease_Homo sapiens_hsa050101.26560600
30Insulin secretion_Homo sapiens_hsa049111.24590557
31Selenocompound metabolism_Homo sapiens_hsa004501.23105679
32Cocaine addiction_Homo sapiens_hsa050301.22934395
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22082094
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.18110129
35Amphetamine addiction_Homo sapiens_hsa050311.17969555
36Dopaminergic synapse_Homo sapiens_hsa047281.15564113
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14176278
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12671052
39Axon guidance_Homo sapiens_hsa043601.11142846
40Synaptic vesicle cycle_Homo sapiens_hsa047211.10847361
41RNA degradation_Homo sapiens_hsa030181.08382406
42Serotonergic synapse_Homo sapiens_hsa047261.08165430
43Hippo signaling pathway_Homo sapiens_hsa043901.05556370
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.04734940
45Olfactory transduction_Homo sapiens_hsa047401.03187837
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98758004
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97963358
48Tryptophan metabolism_Homo sapiens_hsa003800.95271455
49beta-Alanine metabolism_Homo sapiens_hsa004100.94297949
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94037853
51Linoleic acid metabolism_Homo sapiens_hsa005910.89259194
52Wnt signaling pathway_Homo sapiens_hsa043100.88776491
53Collecting duct acid secretion_Homo sapiens_hsa049660.86866910
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86084882
55Fanconi anemia pathway_Homo sapiens_hsa034600.84774962
56Fatty acid elongation_Homo sapiens_hsa000620.83511937
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83495457
58Vitamin B6 metabolism_Homo sapiens_hsa007500.83155162
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81983363
60Ether lipid metabolism_Homo sapiens_hsa005650.80788694
61Long-term depression_Homo sapiens_hsa047300.79809980
62Histidine metabolism_Homo sapiens_hsa003400.79199986
63One carbon pool by folate_Homo sapiens_hsa006700.78677534
64Caffeine metabolism_Homo sapiens_hsa002320.75895753
65Fatty acid metabolism_Homo sapiens_hsa012120.75884268
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74487375
67Circadian rhythm_Homo sapiens_hsa047100.73534168
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.72669589
69Peroxisome_Homo sapiens_hsa041460.72639329
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69421937
71Homologous recombination_Homo sapiens_hsa034400.68743863
72Cholinergic synapse_Homo sapiens_hsa047250.66378513
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64886801
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64370990
75Pyruvate metabolism_Homo sapiens_hsa006200.62819103
76cAMP signaling pathway_Homo sapiens_hsa040240.61693432
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60624007
78Tight junction_Homo sapiens_hsa045300.60229386
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58275719
80Retinol metabolism_Homo sapiens_hsa008300.57532749
81Melanogenesis_Homo sapiens_hsa049160.57190177
82Fatty acid degradation_Homo sapiens_hsa000710.55858219
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55677226
84Salivary secretion_Homo sapiens_hsa049700.53938220
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53774643
86Non-homologous end-joining_Homo sapiens_hsa034500.52458738
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52395545
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52221442
89Chemical carcinogenesis_Homo sapiens_hsa052040.51215331
90Gap junction_Homo sapiens_hsa045400.50705866
91Gastric acid secretion_Homo sapiens_hsa049710.49440858
92ECM-receptor interaction_Homo sapiens_hsa045120.49041466
93Calcium signaling pathway_Homo sapiens_hsa040200.48540051
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48506252
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48282142
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47871744
97Metabolic pathways_Homo sapiens_hsa011000.46854535
98Mismatch repair_Homo sapiens_hsa034300.45865072
99Oocyte meiosis_Homo sapiens_hsa041140.45829553
100Protein digestion and absorption_Homo sapiens_hsa049740.45552256

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