NKX6-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell development (GO:0003323)8.32395331
2regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022357.99827461
3maintenance of gastrointestinal epithelium (GO:0030277)7.86019449
4nodal signaling pathway (GO:0038092)7.65025319
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.98464746
6endocrine pancreas development (GO:0031018)6.86476050
7epithelial structure maintenance (GO:0010669)6.61543332
8regulation of type B pancreatic cell apoptotic process (GO:2000674)6.48617094
9* glandular epithelial cell differentiation (GO:0002067)6.11797245
10ganglion development (GO:0061548)6.00404777
11glandular epithelial cell development (GO:0002068)5.95135903
12negative regulation of gluconeogenesis (GO:0045721)5.85925240
13glucose 6-phosphate metabolic process (GO:0051156)5.68037318
14regulation of gene silencing by RNA (GO:0060966)5.64146032
15regulation of posttranscriptional gene silencing (GO:0060147)5.64146032
16regulation of gene silencing by miRNA (GO:0060964)5.64146032
17axonemal dynein complex assembly (GO:0070286)5.39820558
18synaptic vesicle docking involved in exocytosis (GO:0016081)5.32549516
19exocrine pancreas development (GO:0031017)5.16197971
20adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.12535664
21cilium movement (GO:0003341)5.07440358
22UTP biosynthetic process (GO:0006228)5.03498396
23positive regulation of glycogen biosynthetic process (GO:0045725)4.87452137
24response to hepatocyte growth factor (GO:0035728)4.85935488
25cellular response to hepatocyte growth factor stimulus (GO:0035729)4.85935488
26UTP metabolic process (GO:0046051)4.84605480
27GTP biosynthetic process (GO:0006183)4.83221400
28nitric oxide mediated signal transduction (GO:0007263)4.55289505
29synaptic vesicle maturation (GO:0016188)4.50709432
30negative regulation of digestive system process (GO:0060457)4.45193276
31positive regulation of glycogen metabolic process (GO:0070875)4.44440254
32catechol-containing compound biosynthetic process (GO:0009713)4.44200197
33catecholamine biosynthetic process (GO:0042423)4.44200197
34establishment of apical/basal cell polarity (GO:0035089)4.39724799
35intestinal epithelial cell development (GO:0060576)4.25440253
36response to parathyroid hormone (GO:0071107)4.24498971
37proline biosynthetic process (GO:0006561)4.13617126
38anterior/posterior axis specification, embryo (GO:0008595)4.08949231
39norepinephrine metabolic process (GO:0042415)4.04021702
40DNA replication initiation (GO:0006270)4.02901891
41pre-miRNA processing (GO:0031054)4.02189663
42C21-steroid hormone biosynthetic process (GO:0006700)4.01092258
43ventricular system development (GO:0021591)3.98732384
44negative regulation of catecholamine secretion (GO:0033604)3.93382094
45axoneme assembly (GO:0035082)3.89980506
46chemosensory behavior (GO:0007635)3.87870987
47motile cilium assembly (GO:0044458)3.87318694
48cell migration in hindbrain (GO:0021535)3.82669366
49regulation of bile acid biosynthetic process (GO:0070857)3.82102297
50positive regulation of glycolytic process (GO:0045821)3.77160662
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.75517660
52establishment of monopolar cell polarity (GO:0061162)3.75517660
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.73884604
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.73884604
55digestion (GO:0007586)3.71750844
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68557590
57progesterone metabolic process (GO:0042448)3.68351773
58cilium or flagellum-dependent cell motility (GO:0001539)3.65546377
59embryonic retina morphogenesis in camera-type eye (GO:0060059)3.64655471
60digestive system process (GO:0022600)3.62548012
61glutathione derivative biosynthetic process (GO:1901687)3.62144012
62glutathione derivative metabolic process (GO:1901685)3.62144012
63pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.61306283
64post-embryonic morphogenesis (GO:0009886)3.59469973
65positive regulation of insulin secretion (GO:0032024)3.59371455
66DNA replication-dependent nucleosome organization (GO:0034723)3.57057082
67DNA replication-dependent nucleosome assembly (GO:0006335)3.57057082
68pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.56023603
69histone arginine methylation (GO:0034969)3.55445241
70insulin secretion (GO:0030073)3.54528706
71determination of adult lifespan (GO:0008340)3.53182569
72response to iron ion (GO:0010039)3.50266611
73histone H4-K12 acetylation (GO:0043983)3.49496849
74positive regulation of SMAD protein import into nucleus (GO:0060391)3.49332399
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.48582387
76positive regulation of synapse maturation (GO:0090129)3.44223405
77columnar/cuboidal epithelial cell development (GO:0002066)3.43688693
78intra-S DNA damage checkpoint (GO:0031573)3.42670821
79guanosine-containing compound biosynthetic process (GO:1901070)3.40376031
80protein localization to kinetochore (GO:0034501)3.40071810
81positive regulation of neurotransmitter secretion (GO:0001956)3.39341214
82glutamate secretion (GO:0014047)3.38812331
83regulation of chromatin binding (GO:0035561)3.38780894
84regulation of synaptic vesicle exocytosis (GO:2000300)3.36675986
85CTP metabolic process (GO:0046036)3.36666134
86CTP biosynthetic process (GO:0006241)3.36666134
87auditory behavior (GO:0031223)3.35527793
88neurotransmitter secretion (GO:0007269)3.35483857
89negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.35288370
90folic acid-containing compound biosynthetic process (GO:0009396)3.35056690
91actin filament depolymerization (GO:0030042)3.34079904
92regulation of helicase activity (GO:0051095)3.33764223
93cerebellar Purkinje cell layer development (GO:0021680)3.32882262
94ectodermal placode formation (GO:0060788)3.32776421
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.32563987
96kidney morphogenesis (GO:0060993)3.32476285
97transcription from mitochondrial promoter (GO:0006390)3.32355164
98response to lipoprotein particle (GO:0055094)3.32045836
99cellular response to leptin stimulus (GO:0044320)3.30062122
100pituitary gland development (GO:0021983)3.25786816
101pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.25153291
102epithelial cilium movement (GO:0003351)3.24937376
103negative regulation of insulin secretion (GO:0046676)3.24681393
104regulation of catecholamine metabolic process (GO:0042069)3.24589464
105regulation of dopamine metabolic process (GO:0042053)3.24589464
106positive regulation of neurotransmitter transport (GO:0051590)3.23655005
107DNA unwinding involved in DNA replication (GO:0006268)3.21796233
108ribosomal large subunit biogenesis (GO:0042273)3.21264488
109embryonic placenta development (GO:0001892)3.20031976
110microtubule bundle formation (GO:0001578)3.19698216
111embryonic camera-type eye development (GO:0031076)3.19485331
112regulation of translational fidelity (GO:0006450)3.18411008
113synaptic vesicle exocytosis (GO:0016079)3.16880885
114peptide hormone processing (GO:0016486)3.15090619
115mating behavior (GO:0007617)3.14758628
116positive regulation of peptide hormone secretion (GO:0090277)3.14501695
117GDP-mannose metabolic process (GO:0019673)3.13550266
118establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.12660237
119regulation of clathrin-mediated endocytosis (GO:2000369)3.12332044
120potassium ion export (GO:0071435)3.10340065
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10268728
122establishment or maintenance of apical/basal cell polarity (GO:0035088)3.09709993
123establishment or maintenance of bipolar cell polarity (GO:0061245)3.09709993
124mitotic sister chromatid segregation (GO:0000070)3.09052171
125paraxial mesoderm development (GO:0048339)3.08525391
126positive regulation of Rap GTPase activity (GO:0032854)3.08231298
127positive regulation of peptide secretion (GO:0002793)3.07652759
128dopaminergic neuron differentiation (GO:0071542)3.05425667
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02418595
130cerebellum development (GO:0021549)3.01224564
131negative regulation of response to food (GO:0032096)3.01128890
132negative regulation of appetite (GO:0032099)3.01128890
133DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00652292
134extracellular fibril organization (GO:0043206)3.00254376
135peptidyl-arginine omega-N-methylation (GO:0035247)3.00106201
136regulation of gene silencing (GO:0060968)3.00051699
137activin receptor signaling pathway (GO:0032924)2.99837599
138cerebellar granule cell differentiation (GO:0021707)2.97877783
139negative regulation of organelle assembly (GO:1902116)2.97412092
140nucleoside diphosphate phosphorylation (GO:0006165)2.97368765
141regulation of respiratory gaseous exchange (GO:0043576)2.96100841
142neuron fate specification (GO:0048665)2.95350331
143regulation of cilium movement (GO:0003352)2.95340963
144negative regulation of erythrocyte differentiation (GO:0045647)2.95070411
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.94811968
146O-glycan processing (GO:0016266)2.94340728
147dopamine receptor signaling pathway (GO:0007212)2.94274677
148body morphogenesis (GO:0010171)2.93817047
149sulfation (GO:0051923)2.92539380
150notochord development (GO:0030903)2.92101476
151positive regulation of RNA splicing (GO:0033120)2.91724369
152regulation of insulin secretion (GO:0050796)2.90575933
153peptidyl-tyrosine autophosphorylation (GO:0038083)2.88465361
154ionotropic glutamate receptor signaling pathway (GO:0035235)2.87792170
155response to leptin (GO:0044321)2.87028377
156negative regulation of peptide hormone secretion (GO:0090278)2.85852059
157protein autoprocessing (GO:0016540)2.83782602
158negative regulation of protein oligomerization (GO:0032460)2.83594661
159response to glucose (GO:0009749)2.83387875
160proline metabolic process (GO:0006560)2.83313885
161DNA integration (GO:0015074)2.83172329
162mitotic metaphase plate congression (GO:0007080)2.82778767
163regulation of vesicle fusion (GO:0031338)2.81651011
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81609989
165negative regulation of gene silencing (GO:0060969)2.80067741
166negative regulation of androgen receptor signaling pathway (GO:0060766)2.79691867
167N-glycan processing (GO:0006491)2.79089888
168muscle organ morphogenesis (GO:0048644)2.79025522
169intestinal absorption (GO:0050892)2.79020213
170negative regulation of peptide secretion (GO:0002792)2.78249988
171calcium ion import (GO:0070509)2.78058619
172response to insecticide (GO:0017085)2.77865113
173pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.76233748
174regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.76200603
175regulation of hippo signaling (GO:0035330)2.75630873
176receptor recycling (GO:0001881)2.74968151
177negative regulation of telomerase activity (GO:0051974)2.74746059
178bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72444092
179negative regulation of histone methylation (GO:0031061)2.71157205
180negative regulation of necrotic cell death (GO:0060547)2.71074636
181dopamine biosynthetic process (GO:0042416)2.71068092
182regulation of neuronal synaptic plasticity (GO:0048168)2.70432315
183cAMP biosynthetic process (GO:0006171)2.70261382
184mitochondrial DNA metabolic process (GO:0032042)2.68775698
185regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68248332
186trophectodermal cell differentiation (GO:0001829)2.67603956
187regulation of SMAD protein import into nucleus (GO:0060390)2.67263521
188response to hexose (GO:0009746)2.66269923
189branching involved in mammary gland duct morphogenesis (GO:0060444)2.62654032
190mechanosensory behavior (GO:0007638)2.62522387
191regulation of peptide hormone secretion (GO:0090276)2.62199583
192L-alpha-amino acid transmembrane transport (GO:1902475)2.61739891
193cellular response to catecholamine stimulus (GO:0071870)2.61547646
194cellular response to monoamine stimulus (GO:0071868)2.61547646
195B cell receptor signaling pathway (GO:0050853)2.60546163
196synaptic transmission, glutamatergic (GO:0035249)2.59719530
197positive regulation of glucose metabolic process (GO:0010907)2.59066934
198regulation of peptide secretion (GO:0002791)2.59035726
199establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56766808
200response to dietary excess (GO:0002021)12.8374454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67654352
2EZH2_22144423_ChIP-Seq_EOC_Human4.67642814
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse4.47038052
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.35931568
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.35931568
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.35931568
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse4.02690002
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.76734695
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.70105754
10ESR1_15608294_ChIP-ChIP_MCF-7_Human3.53440289
11RBPJ_22232070_ChIP-Seq_NCS_Mouse3.50753762
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.44158146
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.25528495
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.13798396
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98322408
16REST_21632747_ChIP-Seq_MESCs_Mouse2.92480741
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.89883927
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.77062423
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.76620909
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.71808400
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.70322246
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.69051215
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.68217002
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.66500465
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.63801673
26MYC_22102868_ChIP-Seq_BL_Human2.62198065
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.58064891
28TCF3_18692474_ChIP-Seq_MEFs_Mouse2.56705658
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.47572592
30JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45789961
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.42686771
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.41805027
33STAT3_1855785_ChIP-Seq_MESCs_Mouse2.37638741
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.36479542
35IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35182622
36SOX2_18555785_ChIP-Seq_MESCs_Mouse2.22615509
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.18146757
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14537972
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.14103235
40FOXM1_23109430_ChIP-Seq_U2OS_Human2.12528113
41* LXR_22292898_ChIP-Seq_THP-1_Human2.07319435
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06804965
43KDM2B_26808549_Chip-Seq_K562_Human2.04446421
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03208647
45JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01633865
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.01331265
47BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00468838
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98659013
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91588183
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.91167371
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89937652
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.89048142
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88257883
54* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87584124
55* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87565431
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86425991
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85711047
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85278439
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85278439
60* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83620670
61* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83287586
62* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81509452
63POU5F1_16518401_ChIP-PET_MESCs_Mouse1.81369728
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.79673416
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77994688
66TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.77529468
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.69852136
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67074079
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.65678993
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62791569
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61339302
72KDM2B_26808549_Chip-Seq_DND41_Human1.61030499
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60790722
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.60362698
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60307397
76TCF7_22412390_ChIP-Seq_EML_Mouse1.59368831
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.58804154
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.58340074
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.58299030
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57715503
81KAP1_27257070_Chip-Seq_ESCs_Mouse1.56299673
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56197967
83CREB1_26743006_Chip-Seq_LNCaP_Human1.52544113
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.52452304
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52089078
86* CTCF_27219007_Chip-Seq_Bcells_Human1.50592211
87DROSHA_22980978_ChIP-Seq_HELA_Human1.50428302
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49463613
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.47010810
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.46183029
91PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45935752
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45931196
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44352281
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44172327
95* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40562854
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40256193
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38481710
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38409989
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37644043
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36830143
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36562481
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36151128
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35629080
104VDR_21846776_ChIP-Seq_THP-1_Human1.35147109
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.34055955
106* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33015847
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.32777469
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30047637
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29446824
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29310587
111JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.29257367
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.28432768
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27307027
114P68_20966046_ChIP-Seq_HELA_Human1.26992917
115* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26824096
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26476852
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26010039
118* YY1_22570637_ChIP-Seq_MALME-3M_Human1.25718196
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25551087
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24854156
121STAT1_20625510_ChIP-Seq_HELA_Human1.23552663
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23549882
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22075625
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22031731
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21952947
126ZNF263_19887448_ChIP-Seq_K562_Human1.18841833
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18598763
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18269846
129NANOG_16518401_ChIP-PET_MESCs_Mouse1.18118339
130KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17206186
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17191032
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16250239
133CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15705241
134KDM2B_26808549_Chip-Seq_JURKAT_Human1.15222274
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14154640
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13504295
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11619275
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11065404
139TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10970693
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10722164
141TET1_21490601_ChIP-Seq_MESCs_Mouse1.10485693
142AR_21909140_ChIP-Seq_LNCAP_Human1.10432870
143CIITA_25753668_ChIP-Seq_RAJI_Human1.10374016
144RACK7_27058665_Chip-Seq_MCF-7_Human1.07734213
145ERG_21242973_ChIP-ChIP_JURKAT_Human1.07054394
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06769534
147IRF1_19129219_ChIP-ChIP_H3396_Human1.04910135
148SOX2_16153702_ChIP-ChIP_HESCs_Human1.04870518
149GATA1_19941826_ChIP-Seq_K562_Human1.04623906
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03974539
151RNF2_27304074_Chip-Seq_NSC_Mouse1.03101468
152SMC4_20622854_ChIP-Seq_HELA_Human1.02771506
153E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02264278
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99014571
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97336651
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97110580
157* BCOR_27268052_Chip-Seq_Bcells_Human0.96184252
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96038769
159RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94586473
160* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93878638
161E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93560664
162REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93213597
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91507484
164SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86716411
165XRN2_22483619_ChIP-Seq_HELA_Human0.86628009
166TTF2_22483619_ChIP-Seq_HELA_Human0.86558562
167YY1_21170310_ChIP-Seq_MESCs_Mouse0.86080871
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85917565
169SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84476206
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84459560
171ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84453336
172* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83260631
173MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82419304
174* PHF8_20622854_ChIP-Seq_HELA_Human0.81377867
175MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81277576
176RING1B_27294783_Chip-Seq_NPCs_Mouse0.80698278
177TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80302156
178KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77188501
179WDR5_24793694_ChIP-Seq_LNCAP_Human0.74785901
180STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.73888223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008004_abnormal_stomach_pH8.69678283
2MP0001873_stomach_inflammation5.39547681
3MP0003122_maternal_imprinting5.35289357
4MP0002909_abnormal_adrenal_gland4.72684676
5MP0003136_yellow_coat_color3.41611582
6MP0003806_abnormal_nucleotide_metabolis3.39652228
7MP0008057_abnormal_DNA_replication3.39153054
8MP0001664_abnormal_digestion3.33138630
9MP0003283_abnormal_digestive_organ3.28468014
10MP0004133_heterotaxia3.14234602
11MP0002653_abnormal_ependyma_morphology2.90047304
12* MP0000470_abnormal_stomach_morphology2.86737683
13MP0006292_abnormal_olfactory_placode2.84092674
14MP0005645_abnormal_hypothalamus_physiol2.71874325
15MP0004270_analgesia2.60791859
16MP0002822_catalepsy2.53785332
17MP0000566_synostosis2.49445823
18MP0003195_calcinosis2.48945134
19MP0001944_abnormal_pancreas_morphology2.48593187
20MP0004859_abnormal_synaptic_plasticity2.29630861
21MP0004264_abnormal_extraembryonic_tissu2.18714056
22MP0005423_abnormal_somatic_nervous2.13774378
23MP0004145_abnormal_muscle_electrophysio2.13117865
24MP0004957_abnormal_blastocyst_morpholog2.03768982
25MP0008058_abnormal_DNA_repair1.94279703
26MP0006072_abnormal_retinal_apoptosis1.94109578
27MP0003635_abnormal_synaptic_transmissio1.90821874
28MP0003880_abnormal_central_pattern1.87469230
29MP0003890_abnormal_embryonic-extraembry1.85561509
30MP0010094_abnormal_chromosome_stability1.84297201
31MP0000462_abnormal_digestive_system1.77877554
32MP0005381_digestive/alimentary_phenotyp1.77661823
33MP0009379_abnormal_foot_pigmentation1.72582178
34MP0001663_abnormal_digestive_system1.72301859
35MP0000490_abnormal_crypts_of1.69983870
36MP0003119_abnormal_digestive_system1.67295249
37MP0002734_abnormal_mechanical_nocicepti1.61652706
38MP0002693_abnormal_pancreas_physiology1.61619398
39MP0009745_abnormal_behavioral_response1.60029687
40MP0010030_abnormal_orbit_morphology1.56161205
41MP0003111_abnormal_nucleus_morphology1.56023638
42MP0002249_abnormal_larynx_morphology1.54271648
43MP0005220_abnormal_exocrine_pancreas1.53450287
44MP0000678_abnormal_parathyroid_gland1.51737150
45MP0008995_early_reproductive_senescence1.50104471
46MP0008877_abnormal_DNA_methylation1.49856781
47MP0009672_abnormal_birth_weight1.49304491
48MP0000003_abnormal_adipose_tissue1.46917466
49MP0003943_abnormal_hepatobiliary_system1.44969297
50MP0001529_abnormal_vocalization1.43495976
51MP0010352_gastrointestinal_tract_polyps1.41834871
52MP0006276_abnormal_autonomic_nervous1.41598019
53MP0002084_abnormal_developmental_patter1.33723351
54MP0001986_abnormal_taste_sensitivity1.32413739
55MP0002064_seizures1.30621791
56MP0002063_abnormal_learning/memory/cond1.30246197
57MP0002085_abnormal_embryonic_tissue1.30102990
58MP0005266_abnormal_metabolism1.28538096
59MP0001293_anophthalmia1.27516745
60MP0000049_abnormal_middle_ear1.27096642
61MP0003718_maternal_effect1.26968802
62MP0004811_abnormal_neuron_physiology1.25393701
63* MP0000477_abnormal_intestine_morphology1.24200384
64MP0005623_abnormal_meninges_morphology1.22396392
65MP0001188_hyperpigmentation1.21166346
66MP0008932_abnormal_embryonic_tissue1.20711353
67MP0003077_abnormal_cell_cycle1.14295803
68MP0000778_abnormal_nervous_system1.13467408
69MP0001970_abnormal_pain_threshold1.11588150
70MP0002572_abnormal_emotion/affect_behav1.10572501
71MP0009046_muscle_twitch1.10026669
72MP0005076_abnormal_cell_differentiation1.09790106
73MP0001286_abnormal_eye_development1.09686993
74MP0000613_abnormal_salivary_gland1.09315274
75MP0001730_embryonic_growth_arrest1.07889783
76MP0000955_abnormal_spinal_cord1.05988383
77MP0005647_abnormal_sex_gland1.05281146
78MP0003950_abnormal_plasma_membrane1.04832947
79MP0005165_increased_susceptibility_to1.00874843
80MP0005380_embryogenesis_phenotype1.00693544
81MP0001672_abnormal_embryogenesis/_devel1.00693544
82MP0003755_abnormal_palate_morphology1.00487966
83MP0008260_abnormal_autophagy0.99799219
84MP0002184_abnormal_innervation0.99759401
85MP0000762_abnormal_tongue_morphology0.99513186
86MP0002078_abnormal_glucose_homeostasis0.97310675
87MP0002735_abnormal_chemical_nociception0.96397877
88MP0001697_abnormal_embryo_size0.95495677
89MP0003787_abnormal_imprinting0.93680084
90MP0000537_abnormal_urethra_morphology0.93444200
91MP0004742_abnormal_vestibular_system0.93134393
92MP0002272_abnormal_nervous_system0.92633092
93MP0000350_abnormal_cell_proliferation0.90920977
94MP0004197_abnormal_fetal_growth/weight/0.90137849
95MP0000538_abnormal_urinary_bladder0.89806117
96MP0002067_abnormal_sensory_capabilities0.89607029
97MP0004142_abnormal_muscle_tone0.89116424
98MP0002638_abnormal_pupillary_reflex0.88888898
99MP0002086_abnormal_extraembryonic_tissu0.88534365
100MP0001943_abnormal_respiration0.88149796
101MP0010234_abnormal_vibrissa_follicle0.86726922
102MP0003861_abnormal_nervous_system0.86251259
103MP0003123_paternal_imprinting0.85373407
104MP0008569_lethality_at_weaning0.84228596
105MP0005253_abnormal_eye_physiology0.83955462
106MP0002557_abnormal_social/conspecific_i0.81725083
107MP0002697_abnormal_eye_size0.81652104
108MP0005551_abnormal_eye_electrophysiolog0.81474731
109MP0001502_abnormal_circadian_rhythm0.80184098
110MP0003984_embryonic_growth_retardation0.79805247
111MP0003329_amyloid_beta_deposits0.79132146
112MP0002882_abnormal_neuron_morphology0.79114972
113MP0003938_abnormal_ear_development0.78866785
114* MP0003953_abnormal_hormone_level0.78532267
115MP0002088_abnormal_embryonic_growth/wei0.78067344
116MP0004885_abnormal_endolymph0.78009778
117MP0002080_prenatal_lethality0.77934249
118MP0002127_abnormal_cardiovascular_syste0.77798842
119MP0003941_abnormal_skin_development0.77559121
120MP0001486_abnormal_startle_reflex0.77484275
121MP0003115_abnormal_respiratory_system0.76903440
122MP0002019_abnormal_tumor_incidence0.76529551
123MP0009643_abnormal_urine_homeostasis0.76357608
124MP0002796_impaired_skin_barrier0.76066937
125MP0003937_abnormal_limbs/digits/tail_de0.75961045
126MP0003693_abnormal_embryo_hatching0.74471849
127MP0005257_abnormal_intraocular_pressure0.74455242
128MP0005409_darkened_coat_color0.73420751
129MP0002066_abnormal_motor_capabilities/c0.72958879
130MP0001765_abnormal_ion_homeostasis0.72519334
131MP0002282_abnormal_trachea_morphology0.71304179
132MP0005394_taste/olfaction_phenotype0.71212359
133MP0005499_abnormal_olfactory_system0.71212359
134MP0005379_endocrine/exocrine_gland_phen0.70960905
135MP0002733_abnormal_thermal_nociception0.70803791
136MP0010368_abnormal_lymphatic_system0.69807529
137MP0002069_abnormal_eating/drinking_beha0.69535059
138MP0003121_genomic_imprinting0.68651656
139MP0003879_abnormal_hair_cell0.68171886
140MP0005391_vision/eye_phenotype0.68016518
141MP0001346_abnormal_lacrimal_gland0.67719556
142MP0002234_abnormal_pharynx_morphology0.67709240
143MP0005083_abnormal_biliary_tract0.67575285
144MP0002928_abnormal_bile_duct0.66979676
145MP0002277_abnormal_respiratory_mucosa0.66881658
146MP0005448_abnormal_energy_balance0.64415412
147MP0008789_abnormal_olfactory_epithelium0.63698705
148MP0001731_abnormal_postnatal_growth0.63054928
149MP0003690_abnormal_glial_cell0.62392885
150MP0002152_abnormal_brain_morphology0.62073740
151MP0005501_abnormal_skin_physiology0.62070561
152MP0003172_abnormal_lysosome_physiology0.61989010
153MP0010386_abnormal_urinary_bladder0.61710055
154MP0001145_abnormal_male_reproductive0.61675690
155MP0003936_abnormal_reproductive_system0.61090661
156MP0005195_abnormal_posterior_eye0.61083041
157MP0002332_abnormal_exercise_endurance0.60200541
158MP0000013_abnormal_adipose_tissue0.59813624
159MP0003948_abnormal_gas_homeostasis0.59354698
160MP0002751_abnormal_autonomic_nervous0.59318338
161MP0008770_decreased_survivor_rate0.58224617
162MP0010770_preweaning_lethality0.58204169
163MP0002082_postnatal_lethality0.58204169
164MP0009703_decreased_birth_body0.56782032
165MP0005375_adipose_tissue_phenotype0.56582557
166MP0001849_ear_inflammation0.56394402
167MP0003186_abnormal_redox_activity0.56104060
168MP0000432_abnormal_head_morphology0.55148521
169MP0010307_abnormal_tumor_latency0.54692636
170MP0010769_abnormal_survival0.54617641
171MP0010768_mortality/aging0.53390722
172MP0002970_abnormal_white_adipose0.53230236
173MP0002160_abnormal_reproductive_system0.52706567
174MP0000631_abnormal_neuroendocrine_gland0.52445798
175MP0003633_abnormal_nervous_system0.52246506
176MP0001440_abnormal_grooming_behavior0.51815927
177MP0003935_abnormal_craniofacial_develop0.51814671
178MP0002092_abnormal_eye_morphology0.51626311
179MP0002233_abnormal_nose_morphology0.51258089
180MP0002081_perinatal_lethality0.50654366
181MP0002229_neurodegeneration0.50240519
182MP0001348_abnormal_lacrimal_gland0.49937599
183MP0004924_abnormal_behavior0.49232517

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)9.16344107
2Hyperinsulinemic hypoglycemia (HP:0000825)7.71084795
3Hypoglycemic coma (HP:0001325)6.83289344
4Abnormal pancreas size (HP:0012094)6.49813619
5Symptomatic seizures (HP:0011145)6.43117295
6Male infertility (HP:0003251)6.31227144
7Abnormal ciliary motility (HP:0012262)6.05818423
8Abnormal respiratory motile cilium physiology (HP:0012261)5.88066081
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.71545932
10Abnormal respiratory epithelium morphology (HP:0012253)5.42369767
11Abnormal respiratory motile cilium morphology (HP:0005938)5.42369767
12Abnormality of the pancreatic islet cells (HP:0006476)5.35801679
13Abnormality of endocrine pancreas physiology (HP:0012093)5.35801679
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.99504401
15Hyperphosphatemia (HP:0002905)4.86841423
16Supernumerary spleens (HP:0009799)4.56738404
17Rhinitis (HP:0012384)4.54485639
18Late onset (HP:0003584)4.52000400
19Insulin-resistant diabetes mellitus (HP:0000831)4.44191134
20Hyperparathyroidism (HP:0000843)4.25553186
21Ependymoma (HP:0002888)4.22128839
22Hypercortisolism (HP:0001578)4.19079719
23Progressive cerebellar ataxia (HP:0002073)4.18575155
24Insulin resistance (HP:0000855)3.96697512
25Hyperglycemia (HP:0003074)3.92596885
26Prominent metopic ridge (HP:0005487)3.86208196
27Ketoacidosis (HP:0001993)3.77168948
28Rib fusion (HP:0000902)3.64416810
29Type I diabetes mellitus (HP:0100651)3.64204425
30Asplenia (HP:0001746)3.58193110
31Exocrine pancreatic insufficiency (HP:0001738)3.46990208
32Abnormality of the metopic suture (HP:0005556)3.45243429
33Abnormality of the lower motor neuron (HP:0002366)3.40104895
34Adrenal hypoplasia (HP:0000835)3.37604442
35Aplasia/Hypoplasia of the spleen (HP:0010451)3.33713609
36Hypsarrhythmia (HP:0002521)3.31075772
37Sex reversal (HP:0012245)3.25363196
38Abnormal sex determination (HP:0012244)3.25363196
39EEG with generalized epileptiform discharges (HP:0011198)3.23481056
40Villous atrophy (HP:0011473)3.22483756
41Abnormality of small intestinal villus morphology (HP:0011472)3.22483756
42Hyperthyroidism (HP:0000836)3.22083906
43Increased circulating renin level (HP:0000848)3.21212516
44Abnormality of calcium-phosphate metabolism (HP:0100530)3.20200397
45Epileptiform EEG discharges (HP:0011182)3.19529846
46Back pain (HP:0003418)3.16033302
47Dynein arm defect of respiratory motile cilia (HP:0012255)3.15099537
48Absent/shortened dynein arms (HP:0200106)3.15099537
49Myokymia (HP:0002411)3.14528252
50Agitation (HP:0000713)3.14490368
51Breech presentation (HP:0001623)3.05602277
52Enlarged penis (HP:0000040)3.02317561
53Abnormality of the astrocytes (HP:0100707)2.95996644
54Astrocytoma (HP:0009592)2.95996644
55Testicular neoplasm (HP:0010788)2.95276157
56Elevated erythrocyte sedimentation rate (HP:0003565)2.94187457
57Menstrual irregularities (HP:0000858)2.93005043
58Abnormality of the labia minora (HP:0012880)2.88401586
59Insidious onset (HP:0003587)2.85237200
60Termporal pattern (HP:0011008)2.85237200
61Oral leukoplakia (HP:0002745)2.82899292
62Male pseudohermaphroditism (HP:0000037)2.79320692
63Microretrognathia (HP:0000308)2.78322477
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.75256317
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75256317
66Aplasia/hypoplasia of the humerus (HP:0006507)2.74561231
67Tubulointerstitial nephritis (HP:0001970)2.74441111
68Abnormality of the corticospinal tract (HP:0002492)2.73047138
69Chronic bronchitis (HP:0004469)2.72205508
70Rhabdomyosarcoma (HP:0002859)2.70912299
71Abnormal biliary tract physiology (HP:0012439)2.70653132
72Bile duct proliferation (HP:0001408)2.70653132
73Abnormality of abdominal situs (HP:0011620)2.69026874
74Abdominal situs inversus (HP:0003363)2.69026874
75Abnormal number of incisors (HP:0011064)2.65761654
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64908267
77Concave nail (HP:0001598)2.64509228
78Thin bony cortex (HP:0002753)2.63220638
79Infertility (HP:0000789)2.62763918
80Growth hormone excess (HP:0000845)2.60458483
81Abnormality of magnesium homeostasis (HP:0004921)2.59642967
82Tetany (HP:0001281)2.59501506
83Missing ribs (HP:0000921)2.57619437
84Medulloblastoma (HP:0002885)2.53551729
85Down-sloping shoulders (HP:0200021)2.52181436
86Absent radius (HP:0003974)2.50767309
87Neoplasm of striated muscle (HP:0009728)2.49073420
88Short humerus (HP:0005792)2.47080633
89Hypomagnesemia (HP:0002917)2.46808035
90Occipital encephalocele (HP:0002085)2.46183127
91Bronchiectasis (HP:0002110)2.43902598
92Macroorchidism (HP:0000053)2.43725950
93Truncus arteriosus (HP:0001660)2.43416516
94Ankle clonus (HP:0011448)2.43005127
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.35558594
96Vertebral hypoplasia (HP:0008417)2.35558594
97Annular pancreas (HP:0001734)2.33523623
98Akinesia (HP:0002304)2.33189863
99Ketosis (HP:0001946)2.32841671
100Nephroblastoma (Wilms tumor) (HP:0002667)2.32291909
101Hypercalciuria (HP:0002150)2.30536115
102Absent forearm bone (HP:0003953)2.30207586
103Aplasia involving forearm bones (HP:0009822)2.30207586
104Abnormality of the fetal cardiovascular system (HP:0010948)2.29711086
105Abnormal umbilical cord blood vessels (HP:0011403)2.29711086
106Single umbilical artery (HP:0001195)2.29711086
107Upper limb muscle weakness (HP:0003484)2.29267822
108Hypercalcemia (HP:0003072)2.29248960
109Right ventricular cardiomyopathy (HP:0011663)2.28775583
110Poor suck (HP:0002033)2.26328653
111Abnormal eating behavior (HP:0100738)2.24427180
112Rectal fistula (HP:0100590)2.22924407
113Rectovaginal fistula (HP:0000143)2.22924407
114Pili torti (HP:0003777)2.20178838
115Peritonitis (HP:0002586)2.19221366
116Neoplasm of the oral cavity (HP:0100649)2.18440561
117Hypotelorism (HP:0000601)2.18320916
118Sleep apnea (HP:0010535)2.17021096
119Gastrointestinal stroma tumor (HP:0100723)2.16284261
120Hypochromic microcytic anemia (HP:0004840)2.14311099
121Agnosia (HP:0010524)2.13641809
122Chromsome breakage (HP:0040012)2.13542245
123Amblyopia (HP:0000646)2.13193909
124Polyphagia (HP:0002591)2.11337350
125Septo-optic dysplasia (HP:0100842)2.09290475
126Basal cell carcinoma (HP:0002671)2.09130994
127Agammaglobulinemia (HP:0004432)2.08657073
128Congenital stationary night blindness (HP:0007642)2.08238183
129Muscular hypotonia of the trunk (HP:0008936)2.07264491
130Glioma (HP:0009733)2.06916855
131Embryonal renal neoplasm (HP:0011794)2.05752208
132Large eyes (HP:0001090)2.04033977
133Microvesicular hepatic steatosis (HP:0001414)2.03299749
134Median cleft lip (HP:0000161)2.02126605
135Severe visual impairment (HP:0001141)2.01661364
136Anophthalmia (HP:0000528)2.00935171
137Depression (HP:0000716)1.98958527
138Biliary tract neoplasm (HP:0100574)1.95933539
139Facial cleft (HP:0002006)1.95727112
140Adrenal overactivity (HP:0002717)1.95487598
141Hypocalcemia (HP:0002901)1.94352180
142Natal tooth (HP:0000695)1.91209546
143Abnormal pupillary function (HP:0007686)1.90907696
144Broad distal phalanx of finger (HP:0009836)1.89856162
145Anal atresia (HP:0002023)1.89542516
146Fused cervical vertebrae (HP:0002949)1.88225644
147Progressive external ophthalmoplegia (HP:0000590)1.87931896
148Selective tooth agenesis (HP:0001592)1.87027854
149High anterior hairline (HP:0009890)1.86276917
150Reticulocytopenia (HP:0001896)1.86242469
151Truncal obesity (HP:0001956)1.85687781
152Ventricular fibrillation (HP:0001663)1.85354809
153Septate vagina (HP:0001153)1.84963414
154Maternal diabetes (HP:0009800)1.83938551
155Abnormality of the salivary glands (HP:0010286)1.83697866
156Vaginal fistula (HP:0004320)1.83502685
157Nasal polyposis (HP:0100582)1.82971109
158Intestinal fistula (HP:0100819)1.82625014
159Gastrointestinal atresia (HP:0002589)1.81711292
160Esophageal atresia (HP:0002032)1.81388139
161Adenoma sebaceum (HP:0009720)1.81246319
162Angiofibromas (HP:0010615)1.81246319
163Abnormality of the gastric mucosa (HP:0004295)1.79475577
164Hemiplegia (HP:0002301)1.79245977
165True hermaphroditism (HP:0010459)1.79163171
166Hypochromic anemia (HP:0001931)1.78854679
167Basal ganglia calcification (HP:0002135)1.78342236
168Postaxial foot polydactyly (HP:0001830)1.78101989
169Vertebral clefting (HP:0008428)1.77827847
170Ectopic anus (HP:0004397)1.77632761
171Sparse lateral eyebrow (HP:0005338)1.77385298
172Apathy (HP:0000741)1.75590471
173Limb dystonia (HP:0002451)1.72674010
174Downturned corners of mouth (HP:0002714)1.70158808
17511 pairs of ribs (HP:0000878)1.68936830
176Supranuclear gaze palsy (HP:0000605)1.68832843
177Sporadic (HP:0003745)1.68468289
178Obstructive sleep apnea (HP:0002870)1.68281145
179Focal seizures (HP:0007359)1.67804785
180Spastic gait (HP:0002064)1.66325867
181Restlessness (HP:0000711)1.65437407
182Neoplasm of the heart (HP:0100544)1.64195055
183Abnormality of binocular vision (HP:0011514)1.64122953
184Diplopia (HP:0000651)1.64122953
185Large for gestational age (HP:0001520)1.61849919
186Shawl scrotum (HP:0000049)1.60900522
187Hypophosphatemia (HP:0002148)1.59341636
188Diminished motivation (HP:0000745)1.59060232
189Widely patent fontanelles and sutures (HP:0004492)1.58568319
190Hypoparathyroidism (HP:0000829)1.58542091
191Turricephaly (HP:0000262)1.55945966
192Metaphyseal irregularity (HP:0003025)1.53781666
193Abnormality of the aortic arch (HP:0012303)1.53691391
194Germ cell neoplasia (HP:0100728)1.51917722
195Asymmetric growth (HP:0100555)1.51403537
196Fetal akinesia sequence (HP:0001989)1.51179834
197Postural tremor (HP:0002174)1.50902667
198Action tremor (HP:0002345)1.50860784
199Prolonged neonatal jaundice (HP:0006579)1.49804784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB48.38649216
2TRIB34.18088075
3EPHA23.78036483
4CDK123.72489321
5MARK13.42322289
6NTRK33.30265734
7CASK3.01263722
8TLK12.89073719
9NME12.62915927
10MAPK152.60465091
11EEF2K2.53828455
12DAPK22.52246942
13EPHB22.35508554
14RPS6KB22.34740655
15ICK2.29934364
16SMG12.24941760
17MAPKAPK32.19261933
18PNCK2.04557878
19MST41.95250987
20GRK11.93539859
21HIPK21.90943348
22BRD41.83232050
23PKN21.82852955
24PRKD31.77706825
25CDK81.74745414
26WEE11.72528159
27CDK71.69154085
28PRKG21.64491102
29TTK1.60504683
30NEK21.51982568
31CDC42BPA1.51936469
32DYRK31.47414849
33SIK21.45930222
34RPS6KA41.45799661
35DDR21.39857970
36ERN11.32225478
37MATK1.22908743
38AKT31.22854329
39PLK11.17839982
40MAP3K91.15240186
41NEK11.14787476
42UHMK11.12602306
43BUB11.11491100
44MET1.10211351
45PASK1.08237531
46MARK21.07712358
47PRKCI1.07695928
48NTRK21.07542139
49MAP3K11.06554741
50PRKCH1.04701422
51PRPF4B1.01577614
52MINK11.00669616
53ALK1.00250468
54TYRO30.98760121
55CHEK20.98332720
56LMTK20.98315916
57BMX0.88236661
58WNK30.87476433
59PAK40.86769613
60GRK60.86644770
61SRPK10.86583662
62AURKA0.84974586
63KSR20.83527036
64RIPK10.82868807
65MAP2K40.81023433
66MAP4K10.79940207
67MAP3K40.79834169
68BTK0.79687397
69LATS20.77642662
70PDK10.77339718
71MST1R0.75948348
72CDC70.75824159
73CSK0.74066657
74PKN10.72577658
75PDPK10.71766686
76CSNK1E0.68798125
77GRK50.67422535
78AURKB0.66883568
79MAP2K20.66732894
80YES10.66283830
81CLK10.65595753
82BMPR1B0.65296431
83MAP3K20.64689643
84CHEK10.63611698
85RET0.62937628
86MAP2K70.62875728
87DYRK20.62697438
88SGK2230.60993564
89SGK4940.60993564
90SYK0.60551661
91PRKD20.59019196
92CDK50.57557519
93AKT20.56203017
94SIK10.54704856
95FGFR30.54313886
96MAPK120.53348930
97SGK20.53282688
98MAP3K100.53190456
99MAP3K60.52454838
100PTK20.51222931
101MTOR0.51113506
102STK100.50158186
103CDK20.49484019
104FES0.49138372
105CDK30.48844564
106STK30.48792943
107CDK40.48663485
108MAPK70.48599824
109TESK20.48441933
110CAMKK10.46766759
111PDGFRA0.46747092
112PTK60.46524532
113CDK150.46091870
114LATS10.45345299
115ATM0.45125593
116GSK3A0.44286749
117CDK140.43111523
118CDK11A0.42941312
119FGR0.42817363
120BRAF0.41858547
121TNK20.41783247
122CDK180.41506039
123CSNK2A20.41193746
124SGK30.39697615
125CDK10.39498649
126CDK60.39373187
127KSR10.39220166
128TAOK10.38957399
129DYRK1B0.38909702
130STK110.38026795
131MAP3K110.37919507
132MAPK140.37805905
133MAPK10.36337761
134ARAF0.34616936
135RPS6KA10.34407555
136PAK60.34330770
137ATR0.34328209
138PRKCG0.32910418
139RPS6KB10.31543978
140TESK10.31379883
141PAK10.31110764
142CSNK2A10.30135375
143IRAK20.29910259
144PRKCZ0.29632977
145MAP3K80.29321516
146DYRK1A0.28670497
147DAPK10.28223510
148FGFR20.28177514
149CSNK1D0.27815692
150SGK10.27760553
151ROCK20.27579175
152DAPK30.27347771
153MAPK110.27332091
154RPS6KC10.27326645
155RPS6KL10.27326645
156MAPK130.27226872
157TRPM70.27085615
158GSK3B0.27013465
159STK40.26913630
160IRAK40.26143190
161PHKG10.26107065
162PHKG20.26107065
163CDK90.26014644
164MAPK90.25550209
165PRKDC0.25249741
166TSSK60.24364945
167PRKAA10.24261706
168VRK10.23183650
169RPS6KA20.22854749

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.54931101
2Type II diabetes mellitus_Homo sapiens_hsa049303.21938280
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.20948938
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.04851074
5One carbon pool by folate_Homo sapiens_hsa006702.92587346
6DNA replication_Homo sapiens_hsa030302.82561735
7Base excision repair_Homo sapiens_hsa034102.77953319
8Insulin secretion_Homo sapiens_hsa049112.72384719
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67854524
10Glutathione metabolism_Homo sapiens_hsa004802.48123500
11Ribosome_Homo sapiens_hsa030102.44101913
12Fanconi anemia pathway_Homo sapiens_hsa034602.41161788
13Sulfur relay system_Homo sapiens_hsa041222.32704133
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31413670
15Nucleotide excision repair_Homo sapiens_hsa034202.25941012
16Synaptic vesicle cycle_Homo sapiens_hsa047212.23878750
17Sulfur metabolism_Homo sapiens_hsa009202.08279412
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98123716
19Chemical carcinogenesis_Homo sapiens_hsa052041.97020590
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.91054148
21Spliceosome_Homo sapiens_hsa030401.90743733
22RNA transport_Homo sapiens_hsa030131.90658550
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90644537
24Fructose and mannose metabolism_Homo sapiens_hsa000511.89402824
25Type I diabetes mellitus_Homo sapiens_hsa049401.64083348
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63693994
27Biosynthesis of amino acids_Homo sapiens_hsa012301.62403125
28Homologous recombination_Homo sapiens_hsa034401.59176298
29Gastric acid secretion_Homo sapiens_hsa049711.53764459
30Hippo signaling pathway_Homo sapiens_hsa043901.53374332
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52942679
32Folate biosynthesis_Homo sapiens_hsa007901.52092170
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52015388
34RNA polymerase_Homo sapiens_hsa030201.48047214
35B cell receptor signaling pathway_Homo sapiens_hsa046621.44139829
36Mineral absorption_Homo sapiens_hsa049781.41426870
37Amphetamine addiction_Homo sapiens_hsa050311.41406125
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41153053
39Nitrogen metabolism_Homo sapiens_hsa009101.35399569
40Basal cell carcinoma_Homo sapiens_hsa052171.35060403
41Vibrio cholerae infection_Homo sapiens_hsa051101.30708268
42Pyrimidine metabolism_Homo sapiens_hsa002401.30423993
43Circadian entrainment_Homo sapiens_hsa047131.30411487
44Cocaine addiction_Homo sapiens_hsa050301.30088230
45Long-term potentiation_Homo sapiens_hsa047201.29065111
46mRNA surveillance pathway_Homo sapiens_hsa030151.27850025
47Glutamatergic synapse_Homo sapiens_hsa047241.27841024
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.27279752
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24852243
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24563338
51Morphine addiction_Homo sapiens_hsa050321.23109598
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23085158
53Tight junction_Homo sapiens_hsa045301.22883803
54Cholinergic synapse_Homo sapiens_hsa047251.20933097
55Collecting duct acid secretion_Homo sapiens_hsa049661.14451682
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13589020
57Systemic lupus erythematosus_Homo sapiens_hsa053221.13462780
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10114104
59Steroid biosynthesis_Homo sapiens_hsa001001.08534774
60Carbon metabolism_Homo sapiens_hsa012001.05452869
61Cell cycle_Homo sapiens_hsa041101.02897915
62Huntingtons disease_Homo sapiens_hsa050161.02846684
63Galactose metabolism_Homo sapiens_hsa000521.01867870
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00905961
65Dopaminergic synapse_Homo sapiens_hsa047280.99418850
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97504253
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95679933
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95306455
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89407614
70Selenocompound metabolism_Homo sapiens_hsa004500.87700838
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85645121
72Arginine and proline metabolism_Homo sapiens_hsa003300.83706635
73Insulin signaling pathway_Homo sapiens_hsa049100.82930705
74Pancreatic secretion_Homo sapiens_hsa049720.82686006
75Butanoate metabolism_Homo sapiens_hsa006500.82415841
76Hedgehog signaling pathway_Homo sapiens_hsa043400.82299716
77Non-small cell lung cancer_Homo sapiens_hsa052230.78170771
78Prolactin signaling pathway_Homo sapiens_hsa049170.77245997
79Glucagon signaling pathway_Homo sapiens_hsa049220.76273153
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75668738
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72313655
82Ovarian steroidogenesis_Homo sapiens_hsa049130.72069837
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70932760
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70529969
85Estrogen signaling pathway_Homo sapiens_hsa049150.69983427
86Alcoholism_Homo sapiens_hsa050340.65567128
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65226082
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63186937
89Regulation of autophagy_Homo sapiens_hsa041400.62874101
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62671466
91Thyroid hormone synthesis_Homo sapiens_hsa049180.60925343
92TGF-beta signaling pathway_Homo sapiens_hsa043500.60687775
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59667934
94Purine metabolism_Homo sapiens_hsa002300.59399189
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58015372
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57834641
97Adherens junction_Homo sapiens_hsa045200.57811466
98GnRH signaling pathway_Homo sapiens_hsa049120.57775170
99Taste transduction_Homo sapiens_hsa047420.57752171
100Wnt signaling pathway_Homo sapiens_hsa043100.57367123
101Nicotine addiction_Homo sapiens_hsa050330.56956101
102Non-homologous end-joining_Homo sapiens_hsa034500.56777090
103VEGF signaling pathway_Homo sapiens_hsa043700.56401434
104Linoleic acid metabolism_Homo sapiens_hsa005910.56364116
105Fatty acid biosynthesis_Homo sapiens_hsa000610.55654178
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55187246
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.54831042
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.54581782
109Oxytocin signaling pathway_Homo sapiens_hsa049210.54188160
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53274837
111Lysine degradation_Homo sapiens_hsa003100.53035041
112cAMP signaling pathway_Homo sapiens_hsa040240.50832067
113Pentose phosphate pathway_Homo sapiens_hsa000300.50423318
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49740319
115Vitamin B6 metabolism_Homo sapiens_hsa007500.48529011
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48439242
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48231095
118RNA degradation_Homo sapiens_hsa030180.47245015
119Calcium signaling pathway_Homo sapiens_hsa040200.46897615
120MAPK signaling pathway_Homo sapiens_hsa040100.46450849
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46364635
122p53 signaling pathway_Homo sapiens_hsa041150.45759179
123Bile secretion_Homo sapiens_hsa049760.44969603
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44932618
125Chronic myeloid leukemia_Homo sapiens_hsa052200.44794390
126Arachidonic acid metabolism_Homo sapiens_hsa005900.44450832
127N-Glycan biosynthesis_Homo sapiens_hsa005100.43938494
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43866338
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42254965
130Gap junction_Homo sapiens_hsa045400.42117384
131Long-term depression_Homo sapiens_hsa047300.42009908
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41867304
133Glioma_Homo sapiens_hsa052140.41797033
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.40694144
135Choline metabolism in cancer_Homo sapiens_hsa052310.40027373
136Basal transcription factors_Homo sapiens_hsa030220.39834884
137Bladder cancer_Homo sapiens_hsa052190.38740613
138MicroRNAs in cancer_Homo sapiens_hsa052060.38256552
139Renal cell carcinoma_Homo sapiens_hsa052110.37041124
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36969703
141Fatty acid metabolism_Homo sapiens_hsa012120.36502189
142Salivary secretion_Homo sapiens_hsa049700.36488990
143Notch signaling pathway_Homo sapiens_hsa043300.36283669
144AMPK signaling pathway_Homo sapiens_hsa041520.35951765
145Oocyte meiosis_Homo sapiens_hsa041140.35940546
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33552502
147Metabolic pathways_Homo sapiens_hsa011000.32648874
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32145805
149Renin secretion_Homo sapiens_hsa049240.32135502
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31831955
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.31712827
152Endometrial cancer_Homo sapiens_hsa052130.31183077
153Arginine biosynthesis_Homo sapiens_hsa002200.31010963
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31000463
155ErbB signaling pathway_Homo sapiens_hsa040120.30869978
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.30165615
157Primary immunodeficiency_Homo sapiens_hsa053400.28367602
158Phototransduction_Homo sapiens_hsa047440.27886722
159Cardiac muscle contraction_Homo sapiens_hsa042600.27467462
160Serotonergic synapse_Homo sapiens_hsa047260.26308381
161Ether lipid metabolism_Homo sapiens_hsa005650.25866724
162Phenylalanine metabolism_Homo sapiens_hsa003600.25540929
163Axon guidance_Homo sapiens_hsa043600.25055345
164Dilated cardiomyopathy_Homo sapiens_hsa054140.24798577
165Rap1 signaling pathway_Homo sapiens_hsa040150.24273636
166Pathways in cancer_Homo sapiens_hsa052000.23962415
167GABAergic synapse_Homo sapiens_hsa047270.22980925
168Pancreatic cancer_Homo sapiens_hsa052120.22564317
169Inositol phosphate metabolism_Homo sapiens_hsa005620.22196295
170Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21731111
171mTOR signaling pathway_Homo sapiens_hsa041500.20832433
172Thyroid cancer_Homo sapiens_hsa052160.20642017
173Drug metabolism - other enzymes_Homo sapiens_hsa009830.19991654
174Pyruvate metabolism_Homo sapiens_hsa006200.17072160
175Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16354345

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