NKX2-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cell fate commitment (GO:0072148)9.51938755
2synapsis (GO:0007129)8.32480207
3central nervous system myelination (GO:0022010)7.50991631
4axon ensheathment in central nervous system (GO:0032291)7.50991631
5response to pheromone (GO:0019236)7.50163848
6lens fiber cell development (GO:0070307)7.41058560
7chromosome organization involved in meiosis (GO:0070192)7.33627962
8DNA synthesis involved in DNA repair (GO:0000731)7.33281010
9chondrocyte proliferation (GO:0035988)6.78531912
10synaptonemal complex assembly (GO:0007130)6.73969632
11epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)6.59854747
12male meiosis I (GO:0007141)6.47702521
13piRNA metabolic process (GO:0034587)6.28367971
14male meiosis (GO:0007140)6.16037644
15endocardial cushion morphogenesis (GO:0003203)6.09040228
16thalamus development (GO:0021794)6.05974696
17regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.04669447
18heart valve formation (GO:0003188)5.99652030
19synaptonemal complex organization (GO:0070193)5.90224318
20somite development (GO:0061053)5.80067138
21cell migration involved in heart development (GO:0060973)5.72157862
22axon extension involved in axon guidance (GO:0048846)5.68538516
23neuron projection extension involved in neuron projection guidance (GO:1902284)5.68538516
24mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.65851548
25DNA methylation involved in gamete generation (GO:0043046)5.52195596
26meiotic nuclear division (GO:0007126)5.41513059
27negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.37410859
28collecting duct development (GO:0072044)5.34147770
29meiosis I (GO:0007127)5.32214361
30atrioventricular valve morphogenesis (GO:0003181)5.27534812
31regulation of somitogenesis (GO:0014807)5.24761971
32positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.19125621
33neuronal stem cell maintenance (GO:0097150)5.05909335
34venous blood vessel morphogenesis (GO:0048845)5.02225630
35Notch signaling involved in heart development (GO:0061314)4.94581475
36epithelial cell differentiation involved in prostate gland development (GO:0060742)4.94130488
37negative regulation of oligodendrocyte differentiation (GO:0048715)4.93817108
38midgut development (GO:0007494)4.92537290
39ventricular trabecula myocardium morphogenesis (GO:0003222)4.89125547
40negative regulation of astrocyte differentiation (GO:0048712)4.87832296
41renal system development (GO:0072001)4.85914701
42cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.85424581
43sister chromatid cohesion (GO:0007062)4.85240759
44barbed-end actin filament capping (GO:0051016)4.82019659
45left/right axis specification (GO:0070986)4.80654602
46coronary vasculature morphogenesis (GO:0060977)4.77216307
47cardiac left ventricle morphogenesis (GO:0003214)4.75439778
48embryonic camera-type eye development (GO:0031076)4.74008114
49meiotic chromosome segregation (GO:0045132)4.57745162
50meiotic cell cycle process (GO:1903046)4.52235388
51exocrine pancreas development (GO:0031017)4.50110518
52negative regulation of glial cell differentiation (GO:0045686)4.44381166
53embryonic viscerocranium morphogenesis (GO:0048703)4.44332738
54mesenchyme morphogenesis (GO:0072132)4.38342643
55lens morphogenesis in camera-type eye (GO:0002089)4.37506748
56DNA replication initiation (GO:0006270)4.36983907
57dorsal/ventral neural tube patterning (GO:0021904)4.35828474
58negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.29041634
59positive regulation of astrocyte differentiation (GO:0048711)4.23826858
60regulation of astrocyte differentiation (GO:0048710)4.19805584
61mitotic sister chromatid cohesion (GO:0007064)4.15457373
62DNA unwinding involved in DNA replication (GO:0006268)4.11217680
63DNA packaging (GO:0006323)4.05608494
64DNA replication checkpoint (GO:0000076)4.02644631
65negative regulation of glial cell proliferation (GO:0060253)4.01902001
66DNA strand elongation involved in DNA replication (GO:0006271)3.99248029
67peptidyl-arginine omega-N-methylation (GO:0035247)3.98888065
68nuclear pore complex assembly (GO:0051292)3.97292826
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.94815757
70myoblast migration (GO:0051451)3.93741063
71base-excision repair, AP site formation (GO:0006285)3.87190550
72DNA strand elongation (GO:0022616)3.86073263
73regulation of endothelial cell chemotaxis (GO:2001026)3.85360297
74heart trabecula morphogenesis (GO:0061384)3.84739427
75positive regulation of synapse maturation (GO:0090129)3.79480671
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.77569031
77regulation of chromatin binding (GO:0035561)3.76520359
78regulation of extracellular matrix organization (GO:1903053)3.76272871
79mitotic chromosome condensation (GO:0007076)3.75413351
80negative regulation of smoothened signaling pathway (GO:0045879)3.72612681
81embryonic foregut morphogenesis (GO:0048617)3.72476469
82inner ear receptor cell differentiation (GO:0060113)3.70698195
83positive regulation of neuroblast proliferation (GO:0002052)3.70230601
84lung-associated mesenchyme development (GO:0060484)3.66517428
85nuclear pore organization (GO:0006999)3.64254640
86digestive tract morphogenesis (GO:0048546)3.61570016
87chromosome condensation (GO:0030261)3.61327071
88positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.60466948
89negative regulation of telomerase activity (GO:0051974)3.55734414
90cochlea development (GO:0090102)3.53812446
91heterochromatin organization (GO:0070828)3.53298804
92regulation of mitochondrial translation (GO:0070129)3.52051294
93positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.50335085
94regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.50235876
95positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.49652735
96telomere maintenance via semi-conservative replication (GO:0032201)3.48447082
97cardiac ventricle formation (GO:0003211)3.47080109
98endoderm development (GO:0007492)3.46966756
99chromatin assembly (GO:0031497)3.46940762
100reciprocal DNA recombination (GO:0035825)3.46486628
101reciprocal meiotic recombination (GO:0007131)3.46486628
102peptidyl-arginine methylation (GO:0018216)3.44589611
103peptidyl-arginine N-methylation (GO:0035246)3.44589611
104mitotic sister chromatid segregation (GO:0000070)3.44457060
105neuron fate commitment (GO:0048663)3.44169186
106viral mRNA export from host cell nucleus (GO:0046784)3.41532161
107protein localization to chromosome (GO:0034502)3.41468124
108negative regulation of chromosome segregation (GO:0051985)3.40585004
109apoptotic process involved in morphogenesis (GO:0060561)3.37747600
110regulation of meiosis I (GO:0060631)3.37083642
111mitotic spindle assembly checkpoint (GO:0007094)3.36155327
112metallo-sulfur cluster assembly (GO:0031163)3.35494180
113iron-sulfur cluster assembly (GO:0016226)3.35494180
114negative regulation of myotube differentiation (GO:0010832)3.32589912
115spindle assembly checkpoint (GO:0071173)3.32413012
116type B pancreatic cell development (GO:0003323)3.32236304
117negative regulation of myoblast differentiation (GO:0045662)3.31937122
118negative regulation of epidermis development (GO:0045683)3.30613423
119regulation of transforming growth factor beta2 production (GO:0032909)3.30427913
120positive regulation of keratinocyte differentiation (GO:0045618)3.30408350
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29944025
122nephron tubule development (GO:0072080)3.28684993
123lymph vessel development (GO:0001945)3.28051089
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27422975
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27422975
126negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27422975
127negative regulation of mitotic sister chromatid separation (GO:2000816)3.27422975
128negative regulation of sister chromatid segregation (GO:0033046)3.27422975
129binding of sperm to zona pellucida (GO:0007339)3.26500618
130histone H3-K36 demethylation (GO:0070544)3.25228055
131regulation of transcription from RNA polymerase I promoter (GO:0006356)3.24566913
132spindle checkpoint (GO:0031577)3.23170693
133mesenchymal to epithelial transition (GO:0060231)3.22293874
134spermatid development (GO:0007286)3.22258077
135RNA localization (GO:0006403)3.21605272
136histone H3-K9 demethylation (GO:0033169)3.21405554
137regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20023166
138mitotic spindle checkpoint (GO:0071174)3.19817612
139chromosome organization (GO:0051276)3.19291546
140midbrain development (GO:0030901)3.19081089
141resolution of meiotic recombination intermediates (GO:0000712)3.18836457
142regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.18731239
143regulation of nuclear cell cycle DNA replication (GO:0033262)3.18562925
144embryonic digestive tract morphogenesis (GO:0048557)3.18191264
145DNA replication-dependent nucleosome organization (GO:0034723)3.17908971
146DNA replication-dependent nucleosome assembly (GO:0006335)3.17908971
147histone arginine methylation (GO:0034969)3.17555741
148muscle cell fate commitment (GO:0042693)3.17046787
149embryonic skeletal joint morphogenesis (GO:0060272)3.16203780
150pyrimidine nucleotide catabolic process (GO:0006244)3.14789661
151positive regulation of DNA-templated transcription, initiation (GO:2000144)3.14469938
152negative regulation of gliogenesis (GO:0014014)3.13765731
153response to follicle-stimulating hormone (GO:0032354)3.13461310
154cardiac muscle cell proliferation (GO:0060038)3.13412033
155protein complex localization (GO:0031503)3.11296708
156pore complex assembly (GO:0046931)3.10856809
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10842850
158atrial cardiac muscle cell action potential (GO:0086014)3.10647289
159axonal fasciculation (GO:0007413)3.09562172
160sister chromatid segregation (GO:0000819)3.09383134
161mammary gland epithelial cell differentiation (GO:0060644)3.07931731
162establishment of planar polarity (GO:0001736)3.07252336
163establishment of tissue polarity (GO:0007164)3.07252336
164outer ear morphogenesis (GO:0042473)3.07003348
165cardiac chamber formation (GO:0003207)3.06545870
166DNA biosynthetic process (GO:0071897)3.06331457
167regulation of chromosome segregation (GO:0051983)3.04424333
168regulation of glucocorticoid secretion (GO:2000849)3.02348610
169proximal/distal pattern formation (GO:0009954)3.02131924
170trabecula morphogenesis (GO:0061383)3.01878967
171regulation of synapse maturation (GO:0090128)3.01411734
172response to muramyl dipeptide (GO:0032495)2.99467615
173positive regulation of mesonephros development (GO:0061213)2.97695166
174regulation of oligodendrocyte differentiation (GO:0048713)2.97576735
175cellular response to cholesterol (GO:0071397)2.96997512
176regulation of DNA endoreduplication (GO:0032875)2.96465803
177astrocyte differentiation (GO:0048708)2.96176772
178ribosomal small subunit biogenesis (GO:0042274)2.94534784
179negative regulation of chondrocyte differentiation (GO:0032331)2.94406328
180regulation of mitotic sister chromatid separation (GO:0010965)2.94385350
181regulation of mitotic sister chromatid segregation (GO:0033047)2.94385350
182regulation of sister chromatid segregation (GO:0033045)2.94385350
183protein localization to chromosome, centromeric region (GO:0071459)2.93013467
184response to misfolded protein (GO:0051788)2.87863096
185regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87785263
186regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87785263
187transcription from mitochondrial promoter (GO:0006390)2.87228172
188regulation of double-strand break repair via homologous recombination (GO:0010569)2.85249653
189embryonic heart tube development (GO:0035050)2.82705125
190protein localization to kinetochore (GO:0034501)2.79865635
191mitotic nuclear envelope disassembly (GO:0007077)2.79568648
192thyroid gland development (GO:0030878)2.76858042
193maturation of SSU-rRNA (GO:0030490)2.76335794
194attachment of spindle microtubules to kinetochore (GO:0008608)2.75540215
195telomere maintenance via recombination (GO:0000722)2.73701567
196sperm-egg recognition (GO:0035036)2.70830741
197DNA conformation change (GO:0071103)2.69578514
198negative regulation of mRNA processing (GO:0050686)2.63366891
199pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63324159
200lung epithelium development (GO:0060428)10.2617014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81487183
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse5.53764325
3EZH2_22144423_ChIP-Seq_EOC_Human5.47826677
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.94808697
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83549001
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.62423120
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.59315399
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.51315982
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.45113512
10SRY_22984422_ChIP-ChIP_TESTIS_Rat3.43027479
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38115369
12* CBX2_27304074_Chip-Seq_ESCs_Mouse3.37179602
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.32726845
14* EZH2_27304074_Chip-Seq_ESCs_Mouse3.10716127
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.84139703
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81977737
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70780116
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66875138
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56202620
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54974201
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45588797
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37908650
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35804435
24* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33832306
25* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33832306
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.32482085
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.29767152
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.26940066
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20735970
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19447058
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18605883
32TTF2_22483619_ChIP-Seq_HELA_Human2.14672322
33STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13854086
34TP53_20018659_ChIP-ChIP_R1E_Mouse2.11176145
35* EED_16625203_ChIP-ChIP_MESCs_Mouse2.10205902
36E2F1_21310950_ChIP-Seq_MCF-7_Human2.09752046
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08805573
38* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06395152
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.05526737
40CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03457658
41GABP_19822575_ChIP-Seq_HepG2_Human2.03301694
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02714627
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01983728
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.95693624
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93338652
46KDM5A_27292631_Chip-Seq_BREAST_Human1.90677925
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90651802
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90496746
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88805150
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86150755
51REST_21632747_ChIP-Seq_MESCs_Mouse1.80441918
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76971099
53DCP1A_22483619_ChIP-Seq_HELA_Human1.76912431
54* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76776128
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.76701324
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76305627
57* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74904791
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73370507
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72628964
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72165915
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.70659969
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68994364
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.67780325
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67037545
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65685489
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64413854
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.64006399
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59426886
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59293532
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56656825
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.55177331
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52825337
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52750941
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.51432199
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.51035707
76* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50854774
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49498652
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49311395
79XRN2_22483619_ChIP-Seq_HELA_Human1.46611378
80CIITA_25753668_ChIP-Seq_RAJI_Human1.46160906
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45615506
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.44597069
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38836489
84ZNF263_19887448_ChIP-Seq_K562_Human1.38713662
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38458866
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37441252
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37222339
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34363953
89P68_20966046_ChIP-Seq_HELA_Human1.33234011
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32973911
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32686350
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32112383
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31861339
94MYC_18940864_ChIP-ChIP_HL60_Human1.27888440
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.27120861
96AR_21909140_ChIP-Seq_LNCAP_Human1.26804461
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24154178
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23765047
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23460145
100VDR_23849224_ChIP-Seq_CD4+_Human1.23317221
101* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22931479
102* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20784707
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18851144
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18841148
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18655391
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18535110
107CTCF_27219007_Chip-Seq_Bcells_Human1.16795426
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.15961180
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15560713
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14974130
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.13178638
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09672952
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07785095
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.07174734
115FOXP1_21924763_ChIP-Seq_HESCs_Human1.06348210
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06234597
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05988200
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.05845910
119FOXP3_21729870_ChIP-Seq_TREG_Human1.05392971
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05107065
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03413741
122ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02351444
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01528952
124DROSHA_22980978_ChIP-Seq_HELA_Human1.00670298
125PHF8_20622854_ChIP-Seq_HELA_Human1.00097234
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99891336
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99335748
128RARB_27405468_Chip-Seq_BRAIN_Mouse0.98974395
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97901081
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97643893
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96582794
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96387249
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95290027
134VDR_21846776_ChIP-Seq_THP-1_Human0.94681067
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94491491
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.94432691
137MYC_22102868_ChIP-Seq_BL_Human0.92334754
138MAF_26560356_Chip-Seq_TH2_Human0.92000589
139KDM2B_26808549_Chip-Seq_K562_Human0.88887644
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88724148
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87829183
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85638792
143POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85140830
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85022629
145CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84403293
146LXR_22292898_ChIP-Seq_THP-1_Human0.84144508
147BCOR_27268052_Chip-Seq_Bcells_Human0.83809669
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83709621
149BCL6_27268052_Chip-Seq_Bcells_Human0.83699863
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83672443
151* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83580960
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82432905
153SA1_27219007_Chip-Seq_ERYTHROID_Human0.82360315
154HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81452453
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78132458
156IGF1R_20145208_ChIP-Seq_DFB_Human0.77941419
157TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77582537
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77392422
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76580671
160SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.76394557
161AR_21572438_ChIP-Seq_LNCaP_Human0.75929371
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74628698
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73677017
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73657229
165SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71009169
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70292511
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69953957
168KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68949427
169GATA3_21867929_ChIP-Seq_CD8_Mouse0.68703627
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.67925651
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.67304496
172POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.66016284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.59596464
2MP0005423_abnormal_somatic_nervous5.71664923
3MP0010030_abnormal_orbit_morphology5.35242557
4MP0009780_abnormal_chondrocyte_physiolo5.33372607
5MP0008057_abnormal_DNA_replication4.76646483
6MP0008058_abnormal_DNA_repair3.75096801
7MP0010094_abnormal_chromosome_stability3.73458051
8MP0002102_abnormal_ear_morphology3.67903006
9MP0003693_abnormal_embryo_hatching3.64890881
10MP0003122_maternal_imprinting3.46776249
11MP0002160_abnormal_reproductive_system3.46688841
12MP0008877_abnormal_DNA_methylation3.26841767
13MP0006276_abnormal_autonomic_nervous3.14599756
14MP0000678_abnormal_parathyroid_gland3.01787267
15MP0001346_abnormal_lacrimal_gland2.61426065
16MP0008007_abnormal_cellular_replicative2.57768254
17MP0003283_abnormal_digestive_organ2.36753420
18MP0004381_abnormal_hair_follicle2.32858756
19MP0002249_abnormal_larynx_morphology2.30424163
20MP0001661_extended_life_span2.25320292
21MP0005257_abnormal_intraocular_pressure2.21128493
22MP0004957_abnormal_blastocyst_morpholog2.20556455
23MP0001145_abnormal_male_reproductive2.18590629
24MP0003315_abnormal_perineum_morphology2.13294995
25MP0000653_abnormal_sex_gland2.00277977
26MP0003121_genomic_imprinting2.00070888
27MP0000566_synostosis10.0478306
28MP0005389_reproductive_system_phenotype1.99589513
29MP0002089_abnormal_postnatal_growth/wei1.98710145
30MP0002234_abnormal_pharynx_morphology1.96136426
31MP0001529_abnormal_vocalization1.91788546
32MP0004134_abnormal_chest_morphology1.84489787
33MP0008995_early_reproductive_senescence1.81595543
34MP0000350_abnormal_cell_proliferation1.73531241
35MP0000778_abnormal_nervous_system1.72179488
36MP0001958_emphysema1.68748422
37MP0010307_abnormal_tumor_latency1.67043693
38MP0005187_abnormal_penis_morphology1.64426093
39MP0005645_abnormal_hypothalamus_physiol1.63028667
40MP0000049_abnormal_middle_ear1.60044770
41MP0002751_abnormal_autonomic_nervous1.51364432
42MP0001730_embryonic_growth_arrest1.50027380
43MP0004185_abnormal_adipocyte_glucose1.49877794
44MP0003938_abnormal_ear_development1.42921204
45MP0009053_abnormal_anal_canal1.36423377
46MP0001188_hyperpigmentation1.36306831
47MP0002282_abnormal_trachea_morphology1.34866114
48MP0001119_abnormal_female_reproductive1.30924991
49MP0001919_abnormal_reproductive_system1.27332384
50MP0002085_abnormal_embryonic_tissue1.18758653
51MP0000462_abnormal_digestive_system1.17208281
52MP0001299_abnormal_eye_distance/1.16758078
53MP0003890_abnormal_embryonic-extraembry1.15750833
54MP0005380_embryogenesis_phenotype1.15368674
55MP0001672_abnormal_embryogenesis/_devel1.15368674
56MP0001293_anophthalmia1.15311028
57MP0001697_abnormal_embryo_size1.14752316
58MP0000313_abnormal_cell_death1.12232605
59MP0008961_abnormal_basal_metabolism1.11761167
60MP0009379_abnormal_foot_pigmentation1.10979908
61MP0002877_abnormal_melanocyte_morpholog1.10692562
62MP0000762_abnormal_tongue_morphology1.10045412
63MP0000681_abnormal_thyroid_gland1.10041226
64MP0001968_abnormal_touch/_nociception1.09543091
65MP0000428_abnormal_craniofacial_morphol1.09225794
66MP0000371_diluted_coat_color1.08784696
67MP0003183_abnormal_peptide_metabolism1.08643951
68MP0002084_abnormal_developmental_patter1.06566702
69MP0000733_abnormal_muscle_development1.06032976
70MP0003646_muscle_fatigue1.05400687
71MP0000026_abnormal_inner_ear1.04218110
72MP0004233_abnormal_muscle_weight1.04212540
73MP0005410_abnormal_fertilization1.04177511
74MP0008932_abnormal_embryonic_tissue1.03149749
75MP0004133_heterotaxia1.02405979
76MP0001984_abnormal_olfaction1.01515667
77MP0002095_abnormal_skin_pigmentation1.00834110
78MP0005174_abnormal_tail_pigmentation0.99106555
79MP0003115_abnormal_respiratory_system0.98073244
80MP0003942_abnormal_urinary_system0.96751808
81MP0002080_prenatal_lethality0.96548550
82MP0003699_abnormal_female_reproductive0.96244041
83MP0006035_abnormal_mitochondrial_morpho0.93916383
84MP0003984_embryonic_growth_retardation0.92125710
85MP0003755_abnormal_palate_morphology0.91578398
86MP0004859_abnormal_synaptic_plasticity0.90413982
87MP0000534_abnormal_ureter_morphology0.90364978
88MP0000358_abnormal_cell_content/0.89476862
89MP0002114_abnormal_axial_skeleton0.89086746
90MP0003111_abnormal_nucleus_morphology0.88721913
91MP0000537_abnormal_urethra_morphology0.84955368
92MP0002088_abnormal_embryonic_growth/wei0.84888871
93MP0006036_abnormal_mitochondrial_physio0.81913013
94MP0000003_abnormal_adipose_tissue0.81769635
95MP0000516_abnormal_urinary_system0.81215375
96MP0005367_renal/urinary_system_phenotyp0.81215375
97MP0002098_abnormal_vibrissa_morphology0.80693772
98MP0000467_abnormal_esophagus_morphology0.80607670
99MP0000955_abnormal_spinal_cord0.80461593
100MP0004924_abnormal_behavior0.80228742
101MP0005386_behavior/neurological_phenoty0.80228742
102MP0002092_abnormal_eye_morphology0.78951737
103MP0002697_abnormal_eye_size0.78633767
104MP0003937_abnormal_limbs/digits/tail_de0.77773174
105MP0003718_maternal_effect0.76358727
106MP0001270_distended_abdomen0.75644559
107MP0002184_abnormal_innervation0.75325165
108MP0002938_white_spotting0.74560073
109MP0002638_abnormal_pupillary_reflex0.73840343
110MP0003119_abnormal_digestive_system0.72687134
111MP0005666_abnormal_adipose_tissue0.72330767
112MP0008004_abnormal_stomach_pH0.72114368
113MP0004782_abnormal_surfactant_physiolog0.71149975
114MP0003698_abnormal_male_reproductive0.70253650
115MP0000647_abnormal_sebaceous_gland0.69437673
116MP0008569_lethality_at_weaning0.69198874
117MP0002233_abnormal_nose_morphology0.68509719
118MP0000015_abnormal_ear_pigmentation0.66830689
119MP0003385_abnormal_body_wall0.66708301
120MP0009278_abnormal_bone_marrow0.65786963
121MP0002932_abnormal_joint_morphology0.64560820
122MP0005451_abnormal_body_composition0.63442348
123MP0004742_abnormal_vestibular_system0.63338397
124MP0002653_abnormal_ependyma_morphology0.62411213
125MP0000538_abnormal_urinary_bladder0.62395420
126MP0003763_abnormal_thymus_physiology0.62342966
127MP0003861_abnormal_nervous_system0.61509099
128MP0003948_abnormal_gas_homeostasis0.61506964
129MP0009333_abnormal_splenocyte_physiolog0.60789433
130MP0005248_abnormal_Harderian_gland0.60355189
131MP0003935_abnormal_craniofacial_develop0.60152364
132MP0003941_abnormal_skin_development0.59690560
133MP0001502_abnormal_circadian_rhythm0.59372948
134MP0005646_abnormal_pituitary_gland0.59344115
135MP0003123_paternal_imprinting0.58057856
136MP0005503_abnormal_tendon_morphology0.56835668
137MP0002557_abnormal_social/conspecific_i0.56396618
138MP0005076_abnormal_cell_differentiation0.56319663
139MP0001324_abnormal_eye_pigmentation0.55864115
140MP0001286_abnormal_eye_development0.55675105
141MP0002116_abnormal_craniofacial_bone0.55537717
142MP0001929_abnormal_gametogenesis0.55328059
143MP0002086_abnormal_extraembryonic_tissu0.55287651
144MP0000703_abnormal_thymus_morphology0.54812752
145MP0002882_abnormal_neuron_morphology0.52019092
146MP0000163_abnormal_cartilage_morphology0.51404345
147MP0002075_abnormal_coat/hair_pigmentati0.51389309
148MP0009250_abnormal_appendicular_skeleto0.50592393
149MP0003786_premature_aging0.49959719
150MP0002152_abnormal_brain_morphology0.48422090
151MP0003635_abnormal_synaptic_transmissio0.48328448
152MP0002081_perinatal_lethality0.48248711
153MP0004811_abnormal_neuron_physiology0.48206729
154MP0001186_pigmentation_phenotype0.46247420
155MP0002752_abnormal_somatic_nervous0.46146582
156MP0005391_vision/eye_phenotype0.45424140
157MP0003077_abnormal_cell_cycle0.44609083
158MP0002063_abnormal_learning/memory/cond0.42253302
159MP0002161_abnormal_fertility/fecundity0.41920707
160MP0003879_abnormal_hair_cell0.40994121
161MP0002210_abnormal_sex_determination0.40925970
162MP0005623_abnormal_meninges_morphology0.39656561
163MP0001943_abnormal_respiration0.39472869
164MP0003091_abnormal_cell_migration0.38721413
165MP0000631_abnormal_neuroendocrine_gland0.38058086
166MP0005508_abnormal_skeleton_morphology0.37443395
167MP0002111_abnormal_tail_morphology0.36864421
168MP0002069_abnormal_eating/drinking_beha0.35727730

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)7.00273338
2Coronal craniosynostosis (HP:0004440)5.99111945
3Partial duplication of thumb phalanx (HP:0009944)5.95923746
4Aplasia involving bones of the upper limbs (HP:0009823)5.81664606
5Aplasia of the phalanges of the hand (HP:0009802)5.81664606
6Aplasia involving bones of the extremities (HP:0009825)5.81664606
7Alacrima (HP:0000522)5.27269692
8Partial duplication of the phalanx of hand (HP:0009999)5.23534445
9Broad distal phalanx of finger (HP:0009836)4.74619374
10Polyphagia (HP:0002591)4.49195213
11Decreased lacrimation (HP:0000633)4.49046546
12Thickened helices (HP:0000391)4.28857135
13Megalencephaly (HP:0001355)4.18239943
14Failure to thrive in infancy (HP:0001531)4.10615779
15Duplication of thumb phalanx (HP:0009942)4.08753741
16Recurrent corneal erosions (HP:0000495)3.96466378
17Hypoglycemic seizures (HP:0002173)3.88803676
18Abnormality of the middle phalanges of the toes (HP:0010183)3.88067544
19Xerostomia (HP:0000217)3.82201170
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.80623300
21Double outlet right ventricle (HP:0001719)3.72790400
22Congenital malformation of the right heart (HP:0011723)3.72790400
23Infantile muscular hypotonia (HP:0008947)3.72345304
24Abnormality of the salivary glands (HP:0010286)3.53972632
25Birth length less than 3rd percentile (HP:0003561)3.49085223
26Nasolacrimal duct obstruction (HP:0000579)3.44375752
27Abnormality of the costochondral junction (HP:0000919)3.44188233
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42473215
29Abnormality of the lumbar spine (HP:0100712)3.41635667
30Abnormality of cochlea (HP:0000375)3.40062084
31Abnormality of chromosome segregation (HP:0002916)3.39958731
32Anterior segment dysgenesis (HP:0007700)3.39686685
33Chromsome breakage (HP:0040012)3.38886368
34Mixed hearing impairment (HP:0000410)3.37318897
35Gonadal dysgenesis (HP:0000133)3.36987136
36Abnormality of incisor morphology (HP:0011063)3.29024470
37Conical tooth (HP:0000698)3.28279012
38Volvulus (HP:0002580)3.28237711
39Ectopic kidney (HP:0000086)3.23775666
40Heterotopia (HP:0002282)3.20140906
41Sleep apnea (HP:0010535)3.18884586
42Abnormal umbilical cord blood vessels (HP:0011403)3.17660902
43Single umbilical artery (HP:0001195)3.17660902
44Abnormality of the fetal cardiovascular system (HP:0010948)3.17660902
45Adactyly (HP:0009776)3.17472893
46Transposition of the great arteries (HP:0001669)3.15949423
47Abnormal connection of the cardiac segments (HP:0011545)3.15949423
48Abnormal ventriculo-arterial connection (HP:0011563)3.15949423
49Septate vagina (HP:0001153)3.15558961
50Abnormality of the umbilical cord (HP:0010881)3.11658482
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.98587047
52Rectal prolapse (HP:0002035)2.97337775
53Abnormality of permanent molar morphology (HP:0011071)2.93233279
54Abnormality of the dental root (HP:0006486)2.93233279
55Taurodontia (HP:0000679)2.93233279
56Aplasia cutis congenita (HP:0001057)2.92417817
57Morphological abnormality of the inner ear (HP:0011390)2.89533543
58Preaxial foot polydactyly (HP:0001841)2.88931999
59Abnormality of the right ventricle (HP:0001707)2.88671963
60Neonatal death (HP:0003811)2.84762393
61Uterine leiomyosarcoma (HP:0002891)2.75438238
62Leiomyosarcoma (HP:0100243)2.75438238
63Proximal placement of thumb (HP:0009623)2.74850020
64Increased nuchal translucency (HP:0010880)2.73682363
65Abnormality of molar (HP:0011077)2.73291696
66Abnormality of molar morphology (HP:0011070)2.73291696
67Absent radius (HP:0003974)2.73224347
68Absent forearm bone (HP:0003953)2.72075396
69Aplasia involving forearm bones (HP:0009822)2.72075396
70Oligodactyly (hands) (HP:0001180)2.71593852
71Short femoral neck (HP:0100864)2.70640388
72Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.69446054
73Abnormality of the phalanges of the hallux (HP:0010057)2.67873286
74Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.66239531
75Bifid scrotum (HP:0000048)2.61579348
76Abnormality of the lacrimal duct (HP:0011481)2.61461849
77Optic nerve coloboma (HP:0000588)2.60777666
78Broad hallux (HP:0010055)2.60471658
79Abnormality of the antihelix (HP:0009738)2.58212545
80Facial hemangioma (HP:0000329)2.56091692
81Reticulocytopenia (HP:0001896)2.55107012
82Visceral angiomatosis (HP:0100761)2.54839980
83Resting tremor (HP:0002322)2.54711949
84Neonatal respiratory distress (HP:0002643)2.54640552
85Abnormality of the dental pulp (HP:0006479)2.54449634
8611 pairs of ribs (HP:0000878)2.52205745
87Abnormality of the musculature of the hand (HP:0001421)2.51983637
88Capillary hemangiomas (HP:0005306)2.51893920
89Self-mutilation (HP:0000742)2.50703319
90Symptomatic seizures (HP:0011145)2.50340275
91Rectal fistula (HP:0100590)2.47628845
92Rectovaginal fistula (HP:0000143)2.47628845
93Abnormal eating behavior (HP:0100738)2.47485221
94Abnormal protein glycosylation (HP:0012346)2.47083563
95Abnormal glycosylation (HP:0012345)2.47083563
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47083563
97Abnormal protein N-linked glycosylation (HP:0012347)2.47083563
98Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.44735361
99Preauricular pit (HP:0004467)2.43526270
100Periauricular skin pits (HP:0100277)2.43526270
101Deviation of the thumb (HP:0009603)2.43429327
102Abnormality of the columella (HP:0009929)2.41332690
103Intestinal fistula (HP:0100819)2.40821928
104Spinal canal stenosis (HP:0003416)2.40057743
105High anterior hairline (HP:0009890)2.39527581
106Short middle phalanx of the 5th finger (HP:0004220)2.38766827
107Aplasia/Hypoplasia of the scapulae (HP:0006713)2.37670849
108Hypoplastic scapulae (HP:0000882)2.37670849
109Esotropia (HP:0000565)2.37655134
110Narrow nasal bridge (HP:0000446)2.36847928
111Hypoplastic left heart (HP:0004383)2.35014971
112Microvesicular hepatic steatosis (HP:0001414)2.34120257
113Germ cell neoplasia (HP:0100728)2.32631230
114Squamous cell carcinoma (HP:0002860)2.32268256
115Abnormal number of incisors (HP:0011064)2.31716267
116Hemangiomatosis (HP:0007461)2.30480613
117Gonadotropin excess (HP:0000837)2.30110533
118Occipital encephalocele (HP:0002085)2.28852465
119Microretrognathia (HP:0000308)2.27706844
120Abnormality of the incisor (HP:0000676)2.27561989
121Absent thumb (HP:0009777)2.27109839
122Broad toe (HP:0001837)2.26837004
123Short thumb (HP:0009778)2.24487099
124Ulnar bowing (HP:0003031)2.22225858
125Absent hand (HP:0004050)2.22138530
126Non-midline cleft lip (HP:0100335)2.19447194
127Abnormality of the labia minora (HP:0012880)2.18170329
128Azoospermia (HP:0000027)2.17597125
129Horizontal nystagmus (HP:0000666)2.14162298
130Progressive muscle weakness (HP:0003323)2.13951688
131Abnormality of the nasolacrimal system (HP:0000614)2.13556182
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.13342701
133Overfolded helix (HP:0000396)2.12844325
134Cerebellar dysplasia (HP:0007033)2.12653772
135Atresia of the external auditory canal (HP:0000413)2.12314655
136Slender long bone (HP:0003100)2.12071634
137Thyroid-stimulating hormone excess (HP:0002925)2.10888000
138Growth hormone deficiency (HP:0000824)2.10592466
139Abnormality of chromosome stability (HP:0003220)2.10580174
140Thin ribs (HP:0000883)2.09059409
141Transitional cell carcinoma of the bladder (HP:0006740)2.08994752
142Aplasia/Hypoplasia of the uvula (HP:0010293)2.07811682
143Oligodactyly (HP:0012165)2.07517201
144Hypoplasia of the radius (HP:0002984)2.07042415
145Hypoplasia of the ulna (HP:0003022)2.06789155
146Shoulder girdle muscle weakness (HP:0003547)2.06433522
147Type I transferrin isoform profile (HP:0003642)2.05755319
148Abnormality of salivation (HP:0100755)2.04692875
149Truncus arteriosus (HP:0001660)2.04098997
150Renal dysplasia (HP:0000110)2.02566256
151Breast hypoplasia (HP:0003187)2.01798320
152Skull defect (HP:0001362)2.00484610
153Abnormality of the lower motor neuron (HP:0002366)1.99104072
154Meckel diverticulum (HP:0002245)1.98800799
155Vaginal fistula (HP:0004320)1.98503145
156Porencephaly (HP:0002132)1.97697431
157Intellectual disability, profound (HP:0002187)1.97101425
158Type II lissencephaly (HP:0007260)1.96881909
159Hypoplastic ilia (HP:0000946)1.96877908
160Abnormality of the ileum (HP:0001549)1.96798123
161Small intestinal stenosis (HP:0012848)1.93892980
162Duodenal stenosis (HP:0100867)1.93892980
163Ragged-red muscle fibers (HP:0003200)1.93355057
164Cutaneous melanoma (HP:0012056)1.91862609
165Skin pits (HP:0100276)1.91822533
166Renal cell carcinoma (HP:0005584)1.91467877
167Arnold-Chiari malformation (HP:0002308)1.90460587
168Limited elbow extension (HP:0001377)1.89891499
169Missing ribs (HP:0000921)1.88901972
170Hypoplastic heart (HP:0001961)1.88719628
171Abnormality of the preputium (HP:0100587)1.88591585
172Horseshoe kidney (HP:0000085)1.88129011
173Testicular atrophy (HP:0000029)1.87781829
174Abnormality of the aortic arch (HP:0012303)1.87637879
175Aplasia/Hypoplasia of the macula (HP:0008059)1.85520467
176Osteoarthritis (HP:0002758)1.85360261
177Aplasia/hypoplasia of the femur (HP:0005613)1.85261084
178Abnormally folded helix (HP:0008544)1.85140092
179Embryonal neoplasm (HP:0002898)1.84935951
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84622054
181Hallux valgus (HP:0001822)1.84154062
182Acanthosis nigricans (HP:0000956)1.84066333
183Abnormality of the distal phalanges of the toes (HP:0010182)1.83664039
184Abnormal spermatogenesis (HP:0008669)1.83565868
185Oligomenorrhea (HP:0000876)1.83478396
186Truncal obesity (HP:0001956)1.83099714
187Ectopic anus (HP:0004397)1.83053611
188Triphalangeal thumb (HP:0001199)1.82653633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.01555002
2FGFR34.35056788
3EPHA33.43062126
4MUSK2.95024401
5EPHB22.78744673
6PLK42.70308249
7TLK12.63427227
8CDK82.57853252
9VRK22.57619176
10WNK32.55074414
11EEF2K2.54662028
12MAP3K92.37386970
13SMG12.35053793
14ZAK2.34668662
15FGFR12.30558242
16KDR2.23160321
17IRAK32.21974418
18CHEK22.08398092
19UHMK12.04284083
20BUB111.3350677
21CDC71.96789562
22MELK1.91759540
23PRKD31.80999594
24TYRO31.79300052
25CDK121.79297049
26NME21.66144933
27CCNB11.59261549
28NEK21.53652977
29IRAK21.53133384
30BCR1.46509534
31KSR11.44355840
32BRAF1.41277819
33CDK191.39821779
34SRPK11.38651758
35TAF11.35376293
36SIK31.35270105
37CDK91.32014096
38PDK31.31905226
39PDK41.31905226
40CDK71.29945654
41RPS6KA51.27260341
42VRK11.25967506
43LMTK21.23488043
44MET1.20390585
45NTRK21.17947426
46BCKDK1.12496971
47CDK31.10217827
48DYRK31.07283056
49STK40.97763176
50MAP3K100.96371898
51PINK10.96077248
52ATM0.93018476
53PRKCZ0.89983457
54BMX0.89328062
55ARAF0.88918400
56MARK10.85881587
57STK160.85528931
58PAK60.84848537
59MARK30.84459687
60MAPKAPK50.82234089
61ICK0.82115790
62CDK180.79815569
63FGFR20.79651373
64ROCK20.79608310
65BRSK10.77420851
66IRAK10.76654518
67PDPK10.75126566
68ROCK10.73634715
69CDK150.70903139
70MAP3K70.64178948
71PTK2B0.63897583
72ZAP700.63251001
73ERBB20.61906680
74CDK11A0.61134769
75CDK140.60923186
76MAPK150.59803797
77PDK10.59211980
78PAK40.58599435
79PLK10.58346502
80PLK20.56952432
81PHKG20.55930645
82PHKG10.55930645
83TSSK60.54138699
84MAPK110.53433471
85MAPK90.52988924
86AURKA0.52894827
87MINK10.52576191
88STK38L0.52399993
89MAP3K110.52186604
90TRIB30.51948960
91AKT20.51586576
92PDK20.50650170
93STK380.49667288
94NEK10.49535035
95MAP3K80.47873057
96WEE10.47767608
97CSNK1G10.46351530
98TTK0.45868323
99RPS6KB10.44646599
100KSR20.44588433
101FGR0.42014955
102CDK60.41584247
103CSNK2A10.41443663
104BRD40.41204852
105DDR20.41136291
106PRKCI0.38620567
107ILK0.37245801
108CSNK1G30.36798005
109MST1R0.36511392
110CAMK1D0.36114339
111RPS6KA10.36081099
112CDK50.35746880
113TGFBR10.35528875
114AURKB0.35253388
115PASK0.33486758
116CDK40.33266811
117MAPK100.32642115
118INSRR0.32443134
119CAMKK20.32061979
120PDGFRA0.31851332
121PRKDC0.31277035
122MAP3K40.31122353
123MAP2K20.30623427
124CSNK1E0.30263292
125ATR0.29939208
126TRIM280.28880718
127FGFR40.28135948
128PIM10.28112289
129OXSR10.26575030
130CSNK1A1L0.26331881
131ERN10.22958622
132BLK0.22708926
133FER0.22394736
134PLK30.22081278
135CHEK10.21759402
136BRSK20.20827212
137BMPR1B0.19648600
138MOS0.19225049
139CDK10.18547018
140IGF1R0.18222062
141CAMK1G0.17937978
142DMPK0.17895500
143TNIK0.17510206
144DYRK1B0.17257827
145MAPK130.16637441
146PBK0.16042918
147MTOR0.15717402
148CSNK1G20.15416733
149PAK20.14039529
150CDK20.13769382
151SGK4940.13677963
152SGK2230.13677963
153PRKACG0.11952078
154NEK60.10857197
155NTRK30.10813824

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.72946742
2Hedgehog signaling pathway_Homo sapiens_hsa043404.84366583
3Sulfur relay system_Homo sapiens_hsa041224.78663622
4Dorso-ventral axis formation_Homo sapiens_hsa043204.09844120
5Notch signaling pathway_Homo sapiens_hsa043303.85074701
6Mismatch repair_Homo sapiens_hsa034303.34809853
7Homologous recombination_Homo sapiens_hsa034403.13431111
8Vitamin B6 metabolism_Homo sapiens_hsa007502.94839157
9Prion diseases_Homo sapiens_hsa050202.79399309
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76950787
11Base excision repair_Homo sapiens_hsa034102.62251246
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.60262896
13Melanogenesis_Homo sapiens_hsa049162.56117529
14Wnt signaling pathway_Homo sapiens_hsa043102.27309179
15Nucleotide excision repair_Homo sapiens_hsa034202.20408114
16Hippo signaling pathway_Homo sapiens_hsa043902.20328882
17Bladder cancer_Homo sapiens_hsa052192.13895462
18One carbon pool by folate_Homo sapiens_hsa006702.13595612
19Axon guidance_Homo sapiens_hsa043602.12330443
20Pyrimidine metabolism_Homo sapiens_hsa002402.08244079
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.04828214
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95107477
23Spliceosome_Homo sapiens_hsa030401.89674280
24Non-homologous end-joining_Homo sapiens_hsa034501.81204477
25Oocyte meiosis_Homo sapiens_hsa041141.66651396
26RNA polymerase_Homo sapiens_hsa030201.63769514
27MicroRNAs in cancer_Homo sapiens_hsa052061.60558153
28mRNA surveillance pathway_Homo sapiens_hsa030151.57666876
29Synaptic vesicle cycle_Homo sapiens_hsa047211.55258171
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.43780823
31Collecting duct acid secretion_Homo sapiens_hsa049661.43133984
32RNA degradation_Homo sapiens_hsa030181.42863420
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.40697242
34Basal transcription factors_Homo sapiens_hsa030221.30387977
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.27519782
36Purine metabolism_Homo sapiens_hsa002301.24389754
37Cocaine addiction_Homo sapiens_hsa050301.23036245
38Proteasome_Homo sapiens_hsa030501.20699744
39HTLV-I infection_Homo sapiens_hsa051661.19835693
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19192129
41Cell cycle_Homo sapiens_hsa041101.17912193
42Fatty acid biosynthesis_Homo sapiens_hsa000611.16277038
43Gap junction_Homo sapiens_hsa045401.15990271
44Nicotine addiction_Homo sapiens_hsa050331.12814978
45Circadian entrainment_Homo sapiens_hsa047131.11493304
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10483399
47Glucagon signaling pathway_Homo sapiens_hsa049221.07238025
48Colorectal cancer_Homo sapiens_hsa052101.05164026
49p53 signaling pathway_Homo sapiens_hsa041151.04177140
50Folate biosynthesis_Homo sapiens_hsa007901.02978721
51Lysine degradation_Homo sapiens_hsa003101.00165049
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98587510
53Vibrio cholerae infection_Homo sapiens_hsa051100.97656662
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96544289
55Insulin secretion_Homo sapiens_hsa049110.96191333
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.95490972
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.93660933
58Pathways in cancer_Homo sapiens_hsa052000.91629967
59Amphetamine addiction_Homo sapiens_hsa050310.91325716
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91313755
61Parkinsons disease_Homo sapiens_hsa050120.89002452
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85561220
63RNA transport_Homo sapiens_hsa030130.85485317
64Non-small cell lung cancer_Homo sapiens_hsa052230.85329285
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84898261
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83977434
67mTOR signaling pathway_Homo sapiens_hsa041500.83263532
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82309361
69Ribosome_Homo sapiens_hsa030100.81369880
70GABAergic synapse_Homo sapiens_hsa047270.80284800
71DNA replication_Homo sapiens_hsa030300.77827379
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.74814297
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71304904
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71275235
75Proteoglycans in cancer_Homo sapiens_hsa052050.71135376
76Dopaminergic synapse_Homo sapiens_hsa047280.71089071
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69779616
78Alcoholism_Homo sapiens_hsa050340.69778519
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69229802
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63994741
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63820476
82Cardiac muscle contraction_Homo sapiens_hsa042600.62615595
83Fatty acid elongation_Homo sapiens_hsa000620.59115068
84Renin-angiotensin system_Homo sapiens_hsa046140.59015969
85Arginine and proline metabolism_Homo sapiens_hsa003300.58728870
86Regulation of autophagy_Homo sapiens_hsa041400.58125238
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57598682
88Pyruvate metabolism_Homo sapiens_hsa006200.57032984
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56775192
90Glutamatergic synapse_Homo sapiens_hsa047240.56751849
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56655386
92Pentose phosphate pathway_Homo sapiens_hsa000300.55944692
93MAPK signaling pathway_Homo sapiens_hsa040100.55762883
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55629312
95Pancreatic cancer_Homo sapiens_hsa052120.52915483
96Small cell lung cancer_Homo sapiens_hsa052220.50834571
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50320759
98Oxidative phosphorylation_Homo sapiens_hsa001900.49460290
99Systemic lupus erythematosus_Homo sapiens_hsa053220.49419279
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49172359
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48643100
102Herpes simplex infection_Homo sapiens_hsa051680.47697534
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46135206
104Olfactory transduction_Homo sapiens_hsa047400.45167845
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45091915
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44836814
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43620763
108Endocytosis_Homo sapiens_hsa041440.42397700
109Renin secretion_Homo sapiens_hsa049240.41528929
110Glioma_Homo sapiens_hsa052140.40871052
111Chronic myeloid leukemia_Homo sapiens_hsa052200.40646340
112Epstein-Barr virus infection_Homo sapiens_hsa051690.40508581
113Sulfur metabolism_Homo sapiens_hsa009200.40460802
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.40042271
115Metabolic pathways_Homo sapiens_hsa011000.39671387
116Apoptosis_Homo sapiens_hsa042100.37722832
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.36777384
118VEGF signaling pathway_Homo sapiens_hsa043700.36112094
119Prostate cancer_Homo sapiens_hsa052150.35987183
120Melanoma_Homo sapiens_hsa052180.35931276
121Ras signaling pathway_Homo sapiens_hsa040140.35232930
122Phenylalanine metabolism_Homo sapiens_hsa003600.33791456
123Rap1 signaling pathway_Homo sapiens_hsa040150.33634279
124Phagosome_Homo sapiens_hsa041450.32870675
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32649462
126Morphine addiction_Homo sapiens_hsa050320.32506960
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.32041463
128AMPK signaling pathway_Homo sapiens_hsa041520.31698891
129N-Glycan biosynthesis_Homo sapiens_hsa005100.31350271
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30896791
131TGF-beta signaling pathway_Homo sapiens_hsa043500.30894839
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30227419
133Oxytocin signaling pathway_Homo sapiens_hsa049210.29846879
134PPAR signaling pathway_Homo sapiens_hsa033200.29573760
135Calcium signaling pathway_Homo sapiens_hsa040200.29033823
136ErbB signaling pathway_Homo sapiens_hsa040120.27313685
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26272337
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25728838
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25287389
140Salivary secretion_Homo sapiens_hsa049700.23804525
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23340134
142Fanconi anemia pathway_Homo sapiens_hsa034600.23262434
143Fatty acid metabolism_Homo sapiens_hsa012120.23171001
144Selenocompound metabolism_Homo sapiens_hsa004500.22292549
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21772868
146Choline metabolism in cancer_Homo sapiens_hsa052310.21507209
147Viral carcinogenesis_Homo sapiens_hsa052030.20957872
148Fructose and mannose metabolism_Homo sapiens_hsa000510.20907745
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20451190
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19686510
151Propanoate metabolism_Homo sapiens_hsa006400.19324111
152Huntingtons disease_Homo sapiens_hsa050160.18781955
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18644558
154Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18553726
155Nitrogen metabolism_Homo sapiens_hsa009100.18244987
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17760402
157Biosynthesis of amino acids_Homo sapiens_hsa012300.17005085
158Ether lipid metabolism_Homo sapiens_hsa005650.15560539
159Carbon metabolism_Homo sapiens_hsa012000.14364980
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13179986
161Estrogen signaling pathway_Homo sapiens_hsa049150.12490068

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