NKX2-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)8.80214361
2pattern specification involved in kidney development (GO:0061004)7.37352192
3thyroid hormone metabolic process (GO:0042403)6.92063170
4ganglion development (GO:0061548)6.69910371
5neuronal stem cell maintenance (GO:0097150)5.50128508
6spinal cord association neuron differentiation (GO:0021527)5.38788443
7presynaptic membrane organization (GO:0097090)5.18881006
8positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.10003392
9nephron tubule development (GO:0072080)5.06587461
10sympathetic nervous system development (GO:0048485)5.06336569
11cellular response to nitric oxide (GO:0071732)5.03607927
12regulation of development, heterochronic (GO:0040034)4.67983446
13left/right axis specification (GO:0070986)4.60370869
14negative regulation of oligodendrocyte differentiation (GO:0048715)4.51202987
15* neuron fate commitment (GO:0048663)4.50800731
16lung lobe morphogenesis (GO:0060463)4.48923484
17renal tubule development (GO:0061326)4.45563453
18regulation of timing of cell differentiation (GO:0048505)4.34183876
19* lung secretory cell differentiation (GO:0061140)4.32226867
20sodium-independent organic anion transport (GO:0043252)4.31552225
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.31427680
22sulfate transmembrane transport (GO:1902358)4.23082376
23response to xenobiotic stimulus (GO:0009410)4.20224393
24regulation of response to osmotic stress (GO:0047484)4.15934309
25regulation of phospholipid biosynthetic process (GO:0071071)4.01023494
26nephron epithelium development (GO:0072009)3.98937825
27regulation of sarcomere organization (GO:0060297)3.98010725
28respiratory gaseous exchange (GO:0007585)3.93744737
29pyrimidine nucleobase catabolic process (GO:0006208)3.92966594
30regulation of hippo signaling (GO:0035330)3.92017973
31reflex (GO:0060004)3.91525728
32positive regulation of Notch signaling pathway (GO:0045747)3.90184733
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.88404433
34cellular response to reactive nitrogen species (GO:1902170)3.85443420
35intraciliary transport (GO:0042073)3.83180911
36positive regulation of endothelial cell differentiation (GO:0045603)3.76631174
37negative regulation of epidermal cell differentiation (GO:0045605)3.75089891
38negative regulation of complement activation (GO:0045916)3.69191539
39semaphorin-plexin signaling pathway (GO:0071526)3.67436741
40one-carbon compound transport (GO:0019755)3.63895846
41multicellular organismal movement (GO:0050879)3.61508921
42musculoskeletal movement (GO:0050881)3.61508921
43limb bud formation (GO:0060174)3.59704067
44response to nitric oxide (GO:0071731)3.58770463
45sulfate transport (GO:0008272)3.47427538
46branch elongation of an epithelium (GO:0060602)3.47348733
47cilium or flagellum-dependent cell motility (GO:0001539)3.46515393
48response to folic acid (GO:0051593)3.46094276
49presynaptic membrane assembly (GO:0097105)3.40318206
50regulation of oligodendrocyte differentiation (GO:0048713)3.40150150
51* thyroid gland development (GO:0030878)3.38514934
52* forebrain neuron differentiation (GO:0021879)3.38389623
53negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.32057663
54neuroblast proliferation (GO:0007405)3.31151455
55postsynaptic membrane organization (GO:0001941)3.30702517
56neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.30630214
57negative regulation of interleukin-10 production (GO:0032693)3.26911144
58olfactory bulb development (GO:0021772)3.26780681
59metanephric nephron tubule development (GO:0072234)3.19426818
60metanephric tubule development (GO:0072170)3.19426818
61sodium ion homeostasis (GO:0055078)3.18796199
62negative regulation of protein activation cascade (GO:2000258)3.16486206
63* cerebral cortex neuron differentiation (GO:0021895)3.16455497
64mesodermal cell differentiation (GO:0048333)3.15392798
65neural tube formation (GO:0001841)3.12536417
66regulation of endothelial cell differentiation (GO:0045601)3.12360613
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10549222
68positive regulation of oligodendrocyte differentiation (GO:0048714)3.10514601
69bicarbonate transport (GO:0015701)3.10258885
70branching involved in labyrinthine layer morphogenesis (GO:0060670)3.10179385
71vocalization behavior (GO:0071625)3.08783752
72negative regulation of transcription by competitive promoter binding (GO:0010944)3.08158691
73cell differentiation in spinal cord (GO:0021515)3.07976692
74glomerular epithelial cell development (GO:0072310)3.07106104
75polyol transport (GO:0015791)3.04824944
76endocardial cushion development (GO:0003197)3.02612445
77negative regulation of humoral immune response (GO:0002921)3.01586725
78lung vasculature development (GO:0060426)3.01400228
79cellular anion homeostasis (GO:0030002)3.00691445
80lateral sprouting from an epithelium (GO:0060601)3.00381161
81somite development (GO:0061053)2.99452595
82response to parathyroid hormone (GO:0071107)2.99059253
83regulation of glomerular filtration (GO:0003093)2.96788935
84respiratory tube development (GO:0030323)2.95944991
85lung epithelium development (GO:0060428)2.94177290
86cornea development in camera-type eye (GO:0061303)2.92845537
87hemidesmosome assembly (GO:0031581)2.92328726
88neuronal ion channel clustering (GO:0045161)2.91028591
89nucleobase catabolic process (GO:0046113)2.90498125
90regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89085064
91axis elongation (GO:0003401)2.88007211
92glomerular visceral epithelial cell development (GO:0072015)2.87462687
93glycosphingolipid biosynthetic process (GO:0006688)2.87322359
94segment specification (GO:0007379)2.86921016
95endothelial tube morphogenesis (GO:0061154)2.84535268
96morphogenesis of an endothelium (GO:0003159)2.84535268
97synapse assembly (GO:0007416)2.82964980
98lymphangiogenesis (GO:0001946)2.82519894
99axonal fasciculation (GO:0007413)2.81506851
100regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80781850
101facial nerve structural organization (GO:0021612)2.80688288
102metanephric nephron epithelium development (GO:0072243)2.80603915
103gamma-aminobutyric acid transport (GO:0015812)2.79873666
104ectodermal placode formation (GO:0060788)2.79770335
105lung alveolus development (GO:0048286)2.78647499
106hypothalamus development (GO:0021854)2.78543418
107sequestering of actin monomers (GO:0042989)2.78409326
108protein localization to cilium (GO:0061512)2.77504319
109fibroblast migration (GO:0010761)2.76758115
110phosphate ion homeostasis (GO:0055062)2.75756913
111trivalent inorganic anion homeostasis (GO:0072506)2.75756913
112negative regulation of interleukin-2 production (GO:0032703)2.75544799
113regulation of interleukin-13 production (GO:0032656)2.75491264
114lens morphogenesis in camera-type eye (GO:0002089)2.74688539
115response to vitamin A (GO:0033189)2.73345207
116neuron recognition (GO:0008038)2.72621428
117cardiac ventricle formation (GO:0003211)2.70055402
118axonemal dynein complex assembly (GO:0070286)2.69847958
119cell fate determination (GO:0001709)2.69155350
120glial cell proliferation (GO:0014009)2.69097509
121nephron tubule formation (GO:0072079)2.68391046
122response to hyperoxia (GO:0055093)2.67983148
123response to increased oxygen levels (GO:0036296)2.67983148
124regulation of transcription involved in cell fate commitment (GO:0060850)2.67827183
125negative regulation of epidermis development (GO:0045683)2.67809704
126branching involved in salivary gland morphogenesis (GO:0060445)2.64451710
127regulation of axon extension involved in axon guidance (GO:0048841)2.64336043
128metanephric epithelium development (GO:0072207)2.63801771
129DNA double-strand break processing (GO:0000729)2.63258700
130negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61430312
131negative regulation of cell fate specification (GO:0009996)2.60472727
132calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.60450316
133limb development (GO:0060173)2.60315495
134appendage development (GO:0048736)2.60315495
135axon ensheathment in central nervous system (GO:0032291)2.60267329
136central nervous system myelination (GO:0022010)2.60267329
137substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59765770
138substrate-independent telencephalic tangential migration (GO:0021826)2.59765770
139induction of positive chemotaxis (GO:0050930)2.59236342
140* lung cell differentiation (GO:0060479)2.56501813
141regulation of mitochondrial depolarization (GO:0051900)2.55820341
142phosphate ion transmembrane transport (GO:0035435)2.55807952
143regulation of Notch signaling pathway (GO:0008593)2.55778105
144ethanol oxidation (GO:0006069)2.54361290
145regulation of interleukin-5 production (GO:0032674)2.51880495
146ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50543851
147cilium movement (GO:0003341)2.50317221
148epithelial cilium movement (GO:0003351)2.48817254
149mitochondrion distribution (GO:0048311)2.48137625
150* epithelial tube branching involved in lung morphogenesis (GO:0060441)2.47495458
151photoreceptor cell differentiation (GO:0046530)2.46553290
152eye photoreceptor cell differentiation (GO:0001754)2.46553290
153renal system process involved in regulation of blood volume (GO:0001977)2.43670415
154tight junction assembly (GO:0070830)2.42594375
155lung-associated mesenchyme development (GO:0060484)2.42539823
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41538306
157negative regulation of catenin import into nucleus (GO:0035414)2.40398804
158mesenchymal cell proliferation (GO:0010463)2.40247341
159embryonic foregut morphogenesis (GO:0048617)2.39256047
160phosphate ion transport (GO:0006817)2.37601123
161regulation of vasculogenesis (GO:2001212)2.37065565
162membrane repolarization during action potential (GO:0086011)2.36417315
163regulation of axon guidance (GO:1902667)2.36001939
164positive regulation of synapse assembly (GO:0051965)2.33838103
165virion attachment to host cell (GO:0019062)2.29776795
166adhesion of symbiont to host cell (GO:0044650)2.29776795
167macrophage chemotaxis (GO:0048246)2.26744385
168establishment of apical/basal cell polarity (GO:0035089)2.25459591
169cranial nerve structural organization (GO:0021604)2.25357354
170peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.24512649
171outflow tract septum morphogenesis (GO:0003148)2.23640736
172mating behavior (GO:0007617)2.23449341
173negative regulation of alcohol biosynthetic process (GO:1902931)2.22990072
174surfactant homeostasis (GO:0043129)15.1838337
175chemical homeostasis within a tissue (GO:0048875)12.5334723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.63672199
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60116297
3ZNF274_21170338_ChIP-Seq_K562_Hela3.55495002
4EZH2_22144423_ChIP-Seq_EOC_Human2.87977000
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77328397
6IGF1R_20145208_ChIP-Seq_DFB_Human2.72942035
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.62411757
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54992094
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52690677
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51640080
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49822080
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43920833
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43920833
14* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40915529
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37477903
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27715380
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26237700
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23172616
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22919361
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.18936198
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.17306663
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15200612
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10577998
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08453389
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08352672
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.03578756
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99683174
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99197577
29VDR_22108803_ChIP-Seq_LS180_Human1.97958761
30FUS_26573619_Chip-Seq_HEK293_Human1.96513316
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.92834116
32* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90414016
33* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90094976
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88087433
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87583645
36AHR_22903824_ChIP-Seq_MCF-7_Human1.87418843
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82997791
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82142750
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.81578323
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.75537030
41GBX2_23144817_ChIP-Seq_PC3_Human1.74146070
42P300_19829295_ChIP-Seq_ESCs_Human1.72326773
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.70530446
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69834481
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68201858
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.65206197
47EWS_26573619_Chip-Seq_HEK293_Human1.64303354
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57701192
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54797874
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51494470
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49726296
52ER_23166858_ChIP-Seq_MCF-7_Human1.47730626
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.45846977
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.44895960
55AR_21572438_ChIP-Seq_LNCaP_Human1.43734467
56AR_25329375_ChIP-Seq_VCAP_Human1.42694206
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42087130
58DROSHA_22980978_ChIP-Seq_HELA_Human1.41393022
59STAT3_23295773_ChIP-Seq_U87_Human1.39956847
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39875430
61CBP_20019798_ChIP-Seq_JUKART_Human1.39197545
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39197545
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39073708
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38448537
65TP53_18474530_ChIP-ChIP_U2OS_Human1.38392496
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38015250
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34207325
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.33749365
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33730108
70* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33680364
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32714644
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30840815
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29598004
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25229946
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23947968
76KDM2B_26808549_Chip-Seq_K562_Human1.23097374
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22918175
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22710183
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.22354577
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21425287
81TAF15_26573619_Chip-Seq_HEK293_Human1.19886918
82* TAL1_26923725_Chip-Seq_HPCs_Mouse1.19135022
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.18669242
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18368593
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.17221754
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15773762
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15744362
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14468707
89IRF1_19129219_ChIP-ChIP_H3396_Human1.13225193
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11715511
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10367897
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10210333
93TCF4_23295773_ChIP-Seq_U87_Human1.09475854
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.07997938
95TCF4_22108803_ChIP-Seq_LS180_Human1.07922743
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.07892502
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07838257
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07529806
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05768837
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05174709
101SOX2_20726797_ChIP-Seq_SW620_Human1.05045810
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04658914
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04580288
104KLF5_25053715_ChIP-Seq_YYC3_Human1.03955518
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02484041
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01843430
107JUN_21703547_ChIP-Seq_K562_Human1.01727516
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00180871
109* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00144359
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99888959
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99631438
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97637564
113LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97219659
114* RNF2_27304074_Chip-Seq_NSC_Mouse0.96045897
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.95832402
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95283766
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.95231548
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94987422
119AR_19668381_ChIP-Seq_PC3_Human0.94338385
120* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94254876
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.93573198
122GATA4_25053715_ChIP-Seq_YYC3_Human0.93138953
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92864033
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92799510
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92723615
126RUNX2_22187159_ChIP-Seq_PCA_Human0.92389683
127* KDM2B_26808549_Chip-Seq_REH_Human0.92029717
128* FLI1_21867929_ChIP-Seq_TH2_Mouse0.91460895
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91193925
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.90622525
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90582236
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90391743
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90301231
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89861392
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89690898
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89205393
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.88487114
138SMAD4_21799915_ChIP-Seq_A2780_Human0.87226682
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86639178
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85175027
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85072731
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.84982670
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.84871731
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84786887
145CJUN_26792858_Chip-Seq_BT549_Human0.84337795
146EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84205741
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82544018
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82263756
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82116114
150SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80736936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog8.76611430
2MP0001958_emphysema4.73779880
3* MP0008995_early_reproductive_senescence4.45624179
4MP0000566_synostosis3.88290692
5MP0008004_abnormal_stomach_pH3.87857716
6MP0008789_abnormal_olfactory_epithelium3.69266881
7MP0001177_atelectasis3.36242905
8MP0005394_taste/olfaction_phenotype3.24676737
9MP0005499_abnormal_olfactory_system3.24676737
10MP0005083_abnormal_biliary_tract3.24662545
11MP0002133_abnormal_respiratory_system2.65398951
12MP0005388_respiratory_system_phenotype2.65398951
13MP0000383_abnormal_hair_follicle2.56102462
14* MP0000681_abnormal_thyroid_gland2.46478724
15MP0002295_abnormal_pulmonary_circulatio2.33305518
16MP0010368_abnormal_lymphatic_system2.24521084
17MP0002234_abnormal_pharynx_morphology2.24316288
18MP0000537_abnormal_urethra_morphology2.23479641
19MP0010678_abnormal_skin_adnexa2.20166329
20MP0003724_increased_susceptibility_to2.13603795
21MP0000462_abnormal_digestive_system2.09326692
22MP0000678_abnormal_parathyroid_gland2.01724778
23MP0003303_peritoneal_inflammation1.99785599
24MP0005646_abnormal_pituitary_gland1.90814620
25MP0001879_abnormal_lymphatic_vessel1.85560718
26MP0000049_abnormal_middle_ear1.83034633
27MP0002138_abnormal_hepatobiliary_system1.81802835
28MP0002102_abnormal_ear_morphology1.77495951
29MP0001440_abnormal_grooming_behavior1.71273131
30MP0002822_catalepsy1.66982604
31MP0004272_abnormal_basement_membrane1.65688079
32MP0003122_maternal_imprinting1.61415980
33MP0005248_abnormal_Harderian_gland1.60596885
34MP0002876_abnormal_thyroid_physiology1.56841179
35MP0005645_abnormal_hypothalamus_physiol1.51448851
36MP0002098_abnormal_vibrissa_morphology1.49420988
37MP0001664_abnormal_digestion1.46553025
38MP0001270_distended_abdomen1.46538615
39MP0006072_abnormal_retinal_apoptosis1.42339625
40MP0005253_abnormal_eye_physiology1.41989773
41MP0001984_abnormal_olfaction1.41792042
42MP0002282_abnormal_trachea_morphology1.40405778
43MP0000534_abnormal_ureter_morphology1.36112028
44MP0000778_abnormal_nervous_system1.35367211
45MP0005623_abnormal_meninges_morphology1.28549187
46MP0005167_abnormal_blood-brain_barrier1.27785485
47MP0000026_abnormal_inner_ear1.27772780
48MP0003890_abnormal_embryonic-extraembry1.25942580
49MP0003880_abnormal_central_pattern1.22643809
50MP0001346_abnormal_lacrimal_gland1.20927097
51MP0003938_abnormal_ear_development1.20883651
52MP0002249_abnormal_larynx_morphology1.20380584
53MP0002108_abnormal_muscle_morphology1.15899477
54MP0010352_gastrointestinal_tract_polyps1.15466423
55MP0003950_abnormal_plasma_membrane1.14577940
56MP0004085_abnormal_heartbeat1.12727532
57MP0002277_abnormal_respiratory_mucosa1.12507367
58* MP0001943_abnormal_respiration1.11903039
59MP0002557_abnormal_social/conspecific_i1.11733279
60* MP0001175_abnormal_lung_morphology1.11626940
61MP0003137_abnormal_impulse_conducting1.10582575
62MP0002733_abnormal_thermal_nociception1.07520890
63MP0003755_abnormal_palate_morphology1.05865879
64MP0005423_abnormal_somatic_nervous1.02914890
65MP0005595_abnormal_vascular_smooth0.99980740
66MP0001188_hyperpigmentation0.99726528
67MP0000733_abnormal_muscle_development0.98747608
68MP0004883_abnormal_blood_vessel0.98398423
69MP0006276_abnormal_autonomic_nervous0.94247054
70* MP0003115_abnormal_respiratory_system0.94129418
71MP0003121_genomic_imprinting0.94098743
72MP0003221_abnormal_cardiomyocyte_apopto0.90461767
73MP0000013_abnormal_adipose_tissue0.89938695
74MP0004742_abnormal_vestibular_system0.87872596
75MP0010030_abnormal_orbit_morphology0.87555637
76MP0002132_abnormal_respiratory_system0.86911518
77MP0005187_abnormal_penis_morphology0.85752618
78MP0009745_abnormal_behavioral_response0.85441792
79MP0004043_abnormal_pH_regulation0.83848102
80MP0002752_abnormal_somatic_nervous0.83747640
81MP0009046_muscle_twitch0.83651620
82MP0003948_abnormal_gas_homeostasis0.83081939
83MP0003942_abnormal_urinary_system0.83054327
84MP0005391_vision/eye_phenotype0.78683677
85MP0001986_abnormal_taste_sensitivity0.78006350
86MP0003635_abnormal_synaptic_transmissio0.77889883
87MP0005164_abnormal_response_to0.77844592
88MP0005409_darkened_coat_color0.77622072
89MP0004885_abnormal_endolymph0.77227107
90MP0000751_myopathy0.76472874
91MP0000762_abnormal_tongue_morphology0.76386228
92MP0000467_abnormal_esophagus_morphology0.75485827
93MP0001299_abnormal_eye_distance/0.75238545
94MP0009250_abnormal_appendicular_skeleto0.75052552
95MP0003385_abnormal_body_wall0.74698587
96MP0003191_abnormal_cellular_cholesterol0.74281754
97MP0009780_abnormal_chondrocyte_physiolo0.74008487
98MP0000955_abnormal_spinal_cord0.73009577
99* MP0003786_premature_aging0.72521953
100MP0002168_other_aberrant_phenotype0.70897022
101MP0001286_abnormal_eye_development0.70829229
102MP0005381_digestive/alimentary_phenotyp0.69215704
103* MP0002063_abnormal_learning/memory/cond0.69029715
104MP0002882_abnormal_neuron_morphology0.68554914
105MP0002638_abnormal_pupillary_reflex0.67852369
106* MP0004197_abnormal_fetal_growth/weight/0.66701363
107MP0001968_abnormal_touch/_nociception0.64978599
108* MP0000631_abnormal_neuroendocrine_gland0.64520426
109MP0005195_abnormal_posterior_eye0.64060799
110MP0002735_abnormal_chemical_nociception0.63568188
111MP0008260_abnormal_autophagy0.63463535
112MP0002084_abnormal_developmental_patter0.62030119
113* MP0003119_abnormal_digestive_system0.61772924
114MP0002653_abnormal_ependyma_morphology0.61401144
115MP0001963_abnormal_hearing_physiology0.61200565
116MP0003861_abnormal_nervous_system0.61148979
117MP0002938_white_spotting0.60851963
118MP0005408_hypopigmentation0.60750240
119MP0001340_abnormal_eyelid_morphology0.60274746
120MP0002184_abnormal_innervation0.59354627
121MP0002909_abnormal_adrenal_gland0.58495505
122MP0002751_abnormal_autonomic_nervous0.58356232
123MP0002233_abnormal_nose_morphology0.58119346
124MP0002697_abnormal_eye_size0.58064808
125MP0003935_abnormal_craniofacial_develop0.57723059
126MP0004811_abnormal_neuron_physiology0.57561843
127MP0002069_abnormal_eating/drinking_beha0.56619546
128MP0002925_abnormal_cardiovascular_devel0.56504345
129MP0000627_abnormal_mammary_gland0.56261795
130MP0001502_abnormal_circadian_rhythm0.56046814
131MP0000470_abnormal_stomach_morphology0.54067861
132MP0001970_abnormal_pain_threshold0.53815580
133MP0003937_abnormal_limbs/digits/tail_de0.52081720
134MP0010234_abnormal_vibrissa_follicle0.51812199
135MP0003329_amyloid_beta_deposits0.51278850
136MP0002064_seizures0.50457611
137MP0002796_impaired_skin_barrier0.50398736
138MP0003091_abnormal_cell_migration0.50375637
139MP0008961_abnormal_basal_metabolism0.49098072
140MP0008875_abnormal_xenobiotic_pharmacok0.47998796
141MP0009384_cardiac_valve_regurgitation0.47895711
142MP0000516_abnormal_urinary_system0.47117160
143MP0005367_renal/urinary_system_phenotyp0.47117160
144MP0002332_abnormal_exercise_endurance0.46862924
145MP0004133_heterotaxia0.46659814
146MP0006292_abnormal_olfactory_placode0.46516472
147MP0001501_abnormal_sleep_pattern0.46384591

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.27947870
2Tachypnea (HP:0002789)5.55243310
3Tubulointerstitial fibrosis (HP:0005576)5.54451917
4Renal salt wasting (HP:0000127)5.05552658
5Chronic bronchitis (HP:0004469)5.01806691
6Onycholysis (HP:0001806)4.90145515
7Neurofibrillary tangles (HP:0002185)4.21635594
8Fragile nails (HP:0001808)4.14830044
9Tubulointerstitial nephritis (HP:0001970)4.12252883
10* Goiter (HP:0000853)3.99461122
11Stomach cancer (HP:0012126)3.99351876
12Hyperkalemia (HP:0002153)3.86508499
13* Respiratory distress (HP:0002098)3.76288856
14Gout (HP:0001997)3.75071035
15Pili torti (HP:0003777)3.67027732
16Tubulointerstitial abnormality (HP:0001969)3.57363520
17Tetany (HP:0001281)3.48343148
18Split foot (HP:0001839)3.41141198
19Cerebral inclusion bodies (HP:0100314)3.39871217
20Genetic anticipation (HP:0003743)3.38486742
21Hyperaldosteronism (HP:0000859)3.31991569
22Abnormality of the fingertips (HP:0001211)3.06939848
23Abnormality of chloride homeostasis (HP:0011422)2.95065227
24Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.94802128
25Agitation (HP:0000713)2.91257153
26Buphthalmos (HP:0000557)2.89625180
27Broad metatarsal (HP:0001783)2.89496174
28Hepatoblastoma (HP:0002884)2.79410006
29Sleep apnea (HP:0010535)2.79092238
30Partial duplication of thumb phalanx (HP:0009944)2.78551329
31Tubular atrophy (HP:0000092)2.75591745
32Abnormality of renin-angiotensin system (HP:0000847)2.74237823
33Bronchomalacia (HP:0002780)2.72791282
34Supranuclear gaze palsy (HP:0000605)2.67628959
35Megalencephaly (HP:0001355)2.63235385
36Synostosis involving the elbow (HP:0003938)2.61034030
37Humeroradial synostosis (HP:0003041)2.61034030
38Ulnar bowing (HP:0003031)2.59243087
39Tented upper lip vermilion (HP:0010804)2.58742609
40Thyroid carcinoma (HP:0002890)2.53250530
41Hypothermia (HP:0002045)2.50579181
42Drooling (HP:0002307)2.48631674
43Aplasia involving bones of the extremities (HP:0009825)2.47887873
44Aplasia involving bones of the upper limbs (HP:0009823)2.47887873
45Aplasia of the phalanges of the hand (HP:0009802)2.47887873
46Thickened helices (HP:0000391)2.46898158
47Hyponatremia (HP:0002902)2.43804440
48Visceral angiomatosis (HP:0100761)2.38621116
49Cortical dysplasia (HP:0002539)2.35022369
50Pendular nystagmus (HP:0012043)2.33954943
51* Hyperpituitarism (HP:0010514)2.32749378
52Abnormal respiratory motile cilium morphology (HP:0005938)2.31953803
53Abnormal respiratory epithelium morphology (HP:0012253)2.31953803
54Partial duplication of the phalanx of hand (HP:0009999)2.31350154
55Hypotension (HP:0002615)2.30097938
56Midline defect of the nose (HP:0004122)2.30042605
57Hyperventilation (HP:0002883)2.29713802
58* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.28297121
59Genital tract atresia (HP:0001827)2.28169937
60Turricephaly (HP:0000262)2.25818232
61Vaginal atresia (HP:0000148)2.25414381
62Excessive salivation (HP:0003781)2.24609781
63Intestinal atresia (HP:0011100)2.24024814
64Subacute progressive viral hepatitis (HP:0006572)2.22995185
65Bicornuate uterus (HP:0000813)2.22368457
66Adactyly (HP:0009776)2.21726880
67Hemangiomatosis (HP:0007461)2.20738826
68Abnormality of the labia minora (HP:0012880)2.20472773
69Long toe (HP:0010511)2.19047485
70Polycythemia (HP:0001901)2.18357657
71Abnormality of the ischium (HP:0003174)2.18026019
72Abnormality of the musculature of the pelvis (HP:0001469)2.16650949
73Abnormality of the hip-girdle musculature (HP:0001445)2.16650949
74Nephronophthisis (HP:0000090)2.15511379
75Abnormality of the pubic bones (HP:0003172)2.14507549
76Congenital primary aphakia (HP:0007707)2.14027967
77Medial flaring of the eyebrow (HP:0010747)2.14008104
78Decreased circulating renin level (HP:0003351)2.08366253
79Abnormality of the renal medulla (HP:0100957)2.07095008
80Abnormality of the astrocytes (HP:0100707)2.06818891
81Astrocytoma (HP:0009592)2.06818891
82Failure to thrive in infancy (HP:0001531)2.06189197
83Stage 5 chronic kidney disease (HP:0003774)2.05773027
84Gait imbalance (HP:0002141)2.03626242
85Atrophic scars (HP:0001075)2.02021369
86Progressive cerebellar ataxia (HP:0002073)2.01147436
87Aplasia/Hypoplasia of the sternum (HP:0006714)2.00866008
88Interstitial pulmonary disease (HP:0006530)11.0466802
89Overriding aorta (HP:0002623)1.99512229
90Abnormality of sodium homeostasis (HP:0010931)1.99476953
91Hypoparathyroidism (HP:0000829)1.99120161
92Abnormal hair laboratory examination (HP:0003328)1.98617392
93Adrenal overactivity (HP:0002717)1.98156694
94Morphological abnormality of the middle ear (HP:0008609)1.98084207
95Limb-girdle muscle atrophy (HP:0003797)1.97597300
96Stenosis of the external auditory canal (HP:0000402)1.97592022
97Decreased lacrimation (HP:0000633)1.95863769
98Hyperphosphatemia (HP:0002905)1.95285297
99Short tibia (HP:0005736)1.92367617
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.92194888
101Dyskinesia (HP:0100660)1.91568579
102Shoulder girdle muscle weakness (HP:0003547)1.88012636
103Nasolacrimal duct obstruction (HP:0000579)1.87742203
104Asymmetry of the thorax (HP:0001555)1.87367843
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87267459
106Abnormality of the fetal cardiovascular system (HP:0010948)1.86474703
107Abnormal umbilical cord blood vessels (HP:0011403)1.86474703
108Single umbilical artery (HP:0001195)1.86474703
109Bowing of the arm (HP:0006488)1.86417836
110Bowed forearm bones (HP:0003956)1.86417836
111Nephrogenic diabetes insipidus (HP:0009806)1.86184071
112Milia (HP:0001056)1.86073640
113Laryngomalacia (HP:0001601)1.85983794
114Rapidly progressive (HP:0003678)1.84897500
115Hypoventilation (HP:0002791)1.84033940
116Abnormality of the parathyroid morphology (HP:0011766)1.82865939
117Exotropia (HP:0000577)1.82606125
118Bifid scrotum (HP:0000048)1.81523280
119Absent speech (HP:0001344)1.80709897
120Congenital glaucoma (HP:0001087)1.80574303
121Abnormality of midbrain morphology (HP:0002418)1.80556381
122Molar tooth sign on MRI (HP:0002419)1.80556381
123Germ cell neoplasia (HP:0100728)1.78842056
124Abnormal ciliary motility (HP:0012262)1.77792733
125Shawl scrotum (HP:0000049)1.77705151
126Bronchitis (HP:0012387)1.75973848
127Intellectual disability, moderate (HP:0002342)1.75245284
128Labial hypoplasia (HP:0000066)1.75010857
129True hermaphroditism (HP:0010459)1.74954140
130Abnormality of the lacrimal duct (HP:0011481)1.73382161
131Coronal craniosynostosis (HP:0004440)1.73076109
132Abnormality of the nasal mucosa (HP:0000433)1.72765676
133Hypoplasia of dental enamel (HP:0006297)1.71967476
134Specific learning disability (HP:0001328)1.70618977
135Seborrheic dermatitis (HP:0001051)1.69792104
136Alacrima (HP:0000522)1.69763381
137Ulnar claw (HP:0001178)1.68767300
138Progressive sensorineural hearing impairment (HP:0000408)1.68403681
139Neuroblastoma (HP:0003006)1.67687891
140Primitive neuroectodermal tumor (HP:0030065)1.67687891
141Neuroblastic tumors (HP:0004376)1.67687891
142Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67687891
143Polyphagia (HP:0002591)1.66433378
144Shallow orbits (HP:0000586)1.65955720
145Abnormality of the antihelix (HP:0009738)1.65863421
146Renal hypoplasia (HP:0000089)1.65653679
147Absent hand (HP:0004050)1.65349142
148Alveolar cell carcinoma (HP:0006519)1.64449791
149Patellar aplasia (HP:0006443)1.63774027
150Arnold-Chiari malformation (HP:0002308)1.63195238
151Pulmonary artery stenosis (HP:0004415)1.63137560
152Mildly elevated creatine phosphokinase (HP:0008180)1.62593358
153* Hypothyroidism (HP:0000821)1.62075937
154Abnormality of the pulmonary veins (HP:0011718)1.61992929
155Hypoplastic ischia (HP:0003175)1.61809662
156Postaxial hand polydactyly (HP:0001162)1.61802176
157Abnormal respiratory motile cilium physiology (HP:0012261)1.61750786
158Glomerulosclerosis (HP:0000096)1.60233612
159Glioma (HP:0009733)1.60200881
160Chronic otitis media (HP:0000389)1.60108728
161Abnormality of the intervertebral disk (HP:0005108)1.59812591
162Abnormality of the nasolacrimal system (HP:0000614)1.59760236
163Cupped ear (HP:0000378)1.58637692
164Hypoplastic nipples (HP:0002557)1.58197205
165* Thyroid-stimulating hormone excess (HP:0002925)1.57989647
166Tracheomalacia (HP:0002779)1.57350860
167Loss of speech (HP:0002371)1.56458516
168Neoplasm of the tracheobronchial system (HP:0100552)1.56378112
169Chronic hepatic failure (HP:0100626)1.56358698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.22754895
2CASK3.52622080
3STK243.25960009
4EPHA33.00553123
5MAP4K22.86270489
6DAPK22.75440646
7EPHB22.75084250
8FER2.53389806
9MET2.44726685
10TIE12.42941597
11TRIM282.42925253
12MAP3K42.28301372
13MAP2K72.25075603
14LATS12.21459604
15TGFBR22.18814859
16ERBB32.13964744
17SRPK12.12800894
18STK38L2.09788583
19CAMK1G1.90159164
20MAP3K91.83110010
21EPHB11.76804600
22LRRK21.76687598
23EPHA21.65873012
24ILK1.63465596
25MST41.61405569
26PAK41.59517021
27MAPK151.57885061
28IRAK21.49197209
29CAMK1D1.48515842
30CSNK1A1L1.48064452
31ZAP701.46247927
32CSNK1G31.45641753
33FRK1.43612945
34MKNK11.36709098
35ERBB21.36325574
36RIPK11.31887261
37MAP3K121.28977456
38BCR1.28476981
39MAP3K61.27349880
40PDGFRB1.26366140
41LMTK21.25254159
42CSNK1G21.23538696
43BMPR1B1.23017307
44FES1.18087991
45INSRR1.18081819
46TYRO31.16056837
47CSNK1G11.10389200
48LIMK11.10346858
49MAP3K21.09404607
50STK391.06471649
51MAP2K21.04046417
52FGFR41.02628073
53GRK11.00230015
54ROCK20.96786263
55PTK20.95442331
56AKT30.94949409
57RPS6KA20.93404470
58MKNK20.91699788
59SIK20.90502335
60PRKD20.89256667
61GSK3A0.88080111
62NEK90.87896192
63PTK60.85103144
64RPS6KA40.84986863
65PKN10.82071377
66NEK20.81781161
67MARK20.81005729
68FGFR10.79416757
69IRAK10.78086907
70KSR20.77263903
71MYLK0.77074264
72DAPK30.75384751
73TAOK30.74770758
74MARK10.74497477
75STK100.72372521
76NTRK10.71023142
77PRKD10.70935059
78EPHA40.70469319
79OXSR10.70354353
80PNCK0.70064904
81YES10.67999234
82PHKG10.67452478
83PHKG20.67452478
84WNK30.67399932
85PDGFRA0.67269463
86PRKCE0.66622901
87NTRK30.65290558
88UHMK10.64170519
89CAMK40.63433860
90CAMKK10.62316432
91DDR20.62203545
92SGK20.61430552
93CAMK10.61033386
94CDK60.60420669
95TESK10.58528175
96PRKCZ0.57903643
97BRSK20.57881669
98ICK0.57620693
99NTRK20.55784195
100SIK30.55769979
101MST1R0.54277265
102PAK30.54033604
103BLK0.53651792
104SIK10.53431954
105ERBB40.53276497
106CSNK1A10.52870105
107DYRK20.52178502
108MAP3K70.51591554
109TRIB30.50104398
110KSR10.49766017
111PLK20.48803364
112ROCK10.48677881
113CHUK0.48309135
114FGR0.48040921
115DYRK1B0.47047224
116CSNK1D0.44841782
117PRKCQ0.44215361
118MAP2K40.43852050
119MAPK100.42240507
120PRKAA10.42239044
121SGK4940.42057366
122SGK2230.42057366
123DYRK30.41683330
124DAPK10.40740989
125RET0.40230774
126BRD40.39617080
127EGFR0.39054857
128RPS6KA50.38920169
129FYN0.38862204
130MAPK130.38678654
131CDK190.38661038
132PRPF4B0.38191775
133CDC42BPA0.38025280
134CAMK2B0.37973858
135ABL10.37426175
136RPS6KC10.37313308
137RPS6KL10.37313308
138CDK50.35793952
139CCNB10.35550005
140MAPK90.34435990
141CAMK2A0.33681822
142SGK30.32694280
143TAOK10.30113667
144ATM0.30004095
145MAPK70.29316484
146PRKACB0.28895083
147AKT20.28121414
148IGF1R0.27821868
149STK380.27453981
150ATR0.27428551
151MAPK80.27162812
152NLK0.25553383
153PRKACA0.24663255

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.24346685
2Mineral absorption_Homo sapiens_hsa049782.75370337
3Notch signaling pathway_Homo sapiens_hsa043302.70392790
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68858405
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.63745935
6Protein export_Homo sapiens_hsa030602.49614670
7Circadian rhythm_Homo sapiens_hsa047102.42936463
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.42585339
9beta-Alanine metabolism_Homo sapiens_hsa004102.25369744
10ABC transporters_Homo sapiens_hsa020102.20174789
11Axon guidance_Homo sapiens_hsa043602.15189496
12Thyroid hormone synthesis_Homo sapiens_hsa049182.12324191
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02268131
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92101597
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.84994415
16Histidine metabolism_Homo sapiens_hsa003401.81984744
17Taste transduction_Homo sapiens_hsa047421.81604155
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74899216
19Gastric acid secretion_Homo sapiens_hsa049711.69392818
20ECM-receptor interaction_Homo sapiens_hsa045121.67587318
21Hippo signaling pathway_Homo sapiens_hsa043901.58367894
22Ether lipid metabolism_Homo sapiens_hsa005651.56004102
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55153671
24Salivary secretion_Homo sapiens_hsa049701.54389009
25Basal cell carcinoma_Homo sapiens_hsa052171.53221253
26Tryptophan metabolism_Homo sapiens_hsa003801.50403576
27Fatty acid biosynthesis_Homo sapiens_hsa000611.49707565
28Vibrio cholerae infection_Homo sapiens_hsa051101.48104642
29Tight junction_Homo sapiens_hsa045301.47056605
30Bladder cancer_Homo sapiens_hsa052191.45727298
31Fanconi anemia pathway_Homo sapiens_hsa034601.44631870
32Collecting duct acid secretion_Homo sapiens_hsa049661.44470065
33Nicotine addiction_Homo sapiens_hsa050331.43632699
34Adherens junction_Homo sapiens_hsa045201.43454991
35Non-homologous end-joining_Homo sapiens_hsa034501.36896106
36Renin secretion_Homo sapiens_hsa049241.33797947
37Renal cell carcinoma_Homo sapiens_hsa052111.26663280
38Tyrosine metabolism_Homo sapiens_hsa003501.25818145
39Phagosome_Homo sapiens_hsa041451.25195363
40Lysosome_Homo sapiens_hsa041421.22770921
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22404374
42Selenocompound metabolism_Homo sapiens_hsa004501.21934104
43Butanoate metabolism_Homo sapiens_hsa006501.19107836
44Melanogenesis_Homo sapiens_hsa049161.18501274
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18044721
46Cocaine addiction_Homo sapiens_hsa050301.17925547
47Complement and coagulation cascades_Homo sapiens_hsa046101.17808993
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16282777
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16060355
50Basal transcription factors_Homo sapiens_hsa030221.14644275
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14036511
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11726762
53Endometrial cancer_Homo sapiens_hsa052131.08074428
54Spliceosome_Homo sapiens_hsa030401.07389560
55Steroid biosynthesis_Homo sapiens_hsa001001.07157778
56Morphine addiction_Homo sapiens_hsa050321.03586969
57Rap1 signaling pathway_Homo sapiens_hsa040151.02496208
58Linoleic acid metabolism_Homo sapiens_hsa005911.02096815
59Glutamatergic synapse_Homo sapiens_hsa047241.01579257
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.01577912
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.00691222
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98858385
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97491458
64VEGF signaling pathway_Homo sapiens_hsa043700.97037104
65Circadian entrainment_Homo sapiens_hsa047130.96541477
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96005288
67Gap junction_Homo sapiens_hsa045400.95101773
68Focal adhesion_Homo sapiens_hsa045100.94888295
69Long-term depression_Homo sapiens_hsa047300.93292777
70Propanoate metabolism_Homo sapiens_hsa006400.92736321
71Wnt signaling pathway_Homo sapiens_hsa043100.92121583
72GABAergic synapse_Homo sapiens_hsa047270.91709702
73mRNA surveillance pathway_Homo sapiens_hsa030150.90737591
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89584474
75Amoebiasis_Homo sapiens_hsa051460.89544635
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89374588
77Oxytocin signaling pathway_Homo sapiens_hsa049210.86973216
78ErbB signaling pathway_Homo sapiens_hsa040120.86736118
79Small cell lung cancer_Homo sapiens_hsa052220.86092647
80Synaptic vesicle cycle_Homo sapiens_hsa047210.85928191
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.84854571
82Pathways in cancer_Homo sapiens_hsa052000.84635819
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84476828
84Serotonergic synapse_Homo sapiens_hsa047260.80699363
85Hedgehog signaling pathway_Homo sapiens_hsa043400.80279919
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.78593797
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78214668
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.77440081
89cAMP signaling pathway_Homo sapiens_hsa040240.76293191
90Melanoma_Homo sapiens_hsa052180.76055537
91GnRH signaling pathway_Homo sapiens_hsa049120.75685060
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75633891
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75071847
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74854084
95Colorectal cancer_Homo sapiens_hsa052100.74452738
96Sulfur metabolism_Homo sapiens_hsa009200.73430962
97Rheumatoid arthritis_Homo sapiens_hsa053230.73326437
98Amphetamine addiction_Homo sapiens_hsa050310.72243077
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72006906
100Ras signaling pathway_Homo sapiens_hsa040140.71527687
101Pertussis_Homo sapiens_hsa051330.71498139
102Regulation of autophagy_Homo sapiens_hsa041400.70434908
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69772506
104Proteoglycans in cancer_Homo sapiens_hsa052050.69258164
105Choline metabolism in cancer_Homo sapiens_hsa052310.67970795
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67793997
107Phototransduction_Homo sapiens_hsa047440.67597113
108Fatty acid elongation_Homo sapiens_hsa000620.67549129
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66606724
110Estrogen signaling pathway_Homo sapiens_hsa049150.65676849
111Sphingolipid metabolism_Homo sapiens_hsa006000.64753805
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.63899417
113TGF-beta signaling pathway_Homo sapiens_hsa043500.63515944
114Ovarian steroidogenesis_Homo sapiens_hsa049130.63283441
115Dopaminergic synapse_Homo sapiens_hsa047280.63226460
116Lysine degradation_Homo sapiens_hsa003100.62156589
117Endocytosis_Homo sapiens_hsa041440.61673720
118Dorso-ventral axis formation_Homo sapiens_hsa043200.61651568
119MicroRNAs in cancer_Homo sapiens_hsa052060.61005088
120Thyroid cancer_Homo sapiens_hsa052160.60776210
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60165035
122Pancreatic cancer_Homo sapiens_hsa052120.60116478
123Dilated cardiomyopathy_Homo sapiens_hsa054140.60081635
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59090075
125Long-term potentiation_Homo sapiens_hsa047200.58937160
126Peroxisome_Homo sapiens_hsa041460.57506559
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57437628
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56815107
129Fatty acid degradation_Homo sapiens_hsa000710.56633809
130Oocyte meiosis_Homo sapiens_hsa041140.56205071
131Cholinergic synapse_Homo sapiens_hsa047250.55957294
132Insulin secretion_Homo sapiens_hsa049110.54447067
133Inositol phosphate metabolism_Homo sapiens_hsa005620.53499638
134Malaria_Homo sapiens_hsa051440.51838357
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51320529
136Prion diseases_Homo sapiens_hsa050200.51036573
137Pancreatic secretion_Homo sapiens_hsa049720.50741251
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50248700
139Platelet activation_Homo sapiens_hsa046110.49664435
140Glioma_Homo sapiens_hsa052140.48628350
141Arginine and proline metabolism_Homo sapiens_hsa003300.46857264
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.46400130
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45376469
144Retinol metabolism_Homo sapiens_hsa008300.42466463
145Phenylalanine metabolism_Homo sapiens_hsa003600.38974282
146Chemical carcinogenesis_Homo sapiens_hsa052040.36957171
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35411400
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34275597
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30654712
150Arachidonic acid metabolism_Homo sapiens_hsa005900.28627746

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