NKAIN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of astrocyte differentiation (GO:0048712)5.57386940
2pyrimidine nucleobase catabolic process (GO:0006208)5.41833880
3L-amino acid import (GO:0043092)5.30081697
4alanine transport (GO:0032328)5.25626246
5behavioral response to nicotine (GO:0035095)5.05132928
6amino acid import (GO:0043090)4.98318284
7C4-dicarboxylate transport (GO:0015740)4.94249158
8axon ensheathment in central nervous system (GO:0032291)4.66866728
9central nervous system myelination (GO:0022010)4.66866728
10gamma-aminobutyric acid transport (GO:0015812)4.57432433
11low-density lipoprotein particle remodeling (GO:0034374)4.55596022
12neurotransmitter-gated ion channel clustering (GO:0072578)4.43968121
13forebrain neuron differentiation (GO:0021879)4.43490247
14neurotransmitter uptake (GO:0001504)4.32098493
15L-serine transport (GO:0015825)4.29177571
16axonal fasciculation (GO:0007413)4.27563978
17cellular potassium ion homeostasis (GO:0030007)4.24486329
18cellular response to cholesterol (GO:0071397)4.22467185
19nucleobase catabolic process (GO:0046113)4.14272973
20chondroitin sulfate catabolic process (GO:0030207)4.05833624
21positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.03450211
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.01123414
23substrate-independent telencephalic tangential migration (GO:0021826)4.01123414
24regulation of astrocyte differentiation (GO:0048710)3.96512802
25response to auditory stimulus (GO:0010996)3.89750344
26neuron recognition (GO:0008038)3.88065495
27positive regulation of cellular amide metabolic process (GO:0034250)3.87863892
28negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.86819376
29dendritic spine morphogenesis (GO:0060997)3.85323825
30cell communication by electrical coupling (GO:0010644)3.81044241
31glial cell proliferation (GO:0014009)3.77796507
32sodium ion export (GO:0071436)3.74780699
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74754449
34neuron cell-cell adhesion (GO:0007158)3.72545686
35establishment of mitochondrion localization (GO:0051654)3.67045832
36nonmotile primary cilium assembly (GO:0035058)3.66093356
37serine transport (GO:0032329)3.61302078
38exploration behavior (GO:0035640)3.60494404
39regulation of beta-amyloid formation (GO:1902003)3.59826044
40dermatan sulfate biosynthetic process (GO:0030208)3.58049770
41oligodendrocyte differentiation (GO:0048709)3.53642741
42regulation of phospholipid biosynthetic process (GO:0071071)3.53360060
43negative regulation of glial cell differentiation (GO:0045686)3.52767307
44cellular response to sterol (GO:0036315)3.52573195
45postsynaptic membrane organization (GO:0001941)3.51797220
46negative regulation of sodium ion transport (GO:0010766)3.50505622
47retinal ganglion cell axon guidance (GO:0031290)3.50367557
48dermatan sulfate metabolic process (GO:0030205)3.49342735
49neuronal ion channel clustering (GO:0045161)3.49205930
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.48507306
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48294144
52response to gravity (GO:0009629)3.48042530
53auditory behavior (GO:0031223)3.47284256
54presynaptic membrane assembly (GO:0097105)3.42857398
55negative regulation of smoothened signaling pathway (GO:0045879)3.42002451
56neuronal stem cell maintenance (GO:0097150)3.40876399
57calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.40156542
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39746228
59atrial cardiac muscle cell action potential (GO:0086014)3.39323096
60proline transport (GO:0015824)3.38917676
61locomotory exploration behavior (GO:0035641)3.33801642
62cellular sodium ion homeostasis (GO:0006883)3.32094871
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30075331
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29880100
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.28915410
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27829868
67synapse assembly (GO:0007416)3.27640900
68vocalization behavior (GO:0071625)3.27277493
69cell migration in hindbrain (GO:0021535)3.21847011
70regulation of timing of cell differentiation (GO:0048505)3.19013569
71synaptic transmission, cholinergic (GO:0007271)3.17206304
72regulation of inositol phosphate biosynthetic process (GO:0010919)3.16969906
73lateral sprouting from an epithelium (GO:0060601)3.16290478
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14510460
75ovulation cycle (GO:0042698)3.13635247
76glutamate receptor signaling pathway (GO:0007215)3.12810952
77negative regulation of oligodendrocyte differentiation (GO:0048715)3.11086125
78spinal cord association neuron differentiation (GO:0021527)3.10998125
79myelination in peripheral nervous system (GO:0022011)3.09754499
80peripheral nervous system axon ensheathment (GO:0032292)3.09754499
81transmission of nerve impulse (GO:0019226)3.09619726
82blood vessel maturation (GO:0001955)3.05634749
83epithelial cilium movement (GO:0003351)3.05538632
84acidic amino acid transport (GO:0015800)3.03762175
85potassium ion import (GO:0010107)3.03640164
86mitochondrion transport along microtubule (GO:0047497)3.00388715
87establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00388715
88regulation of synapse structural plasticity (GO:0051823)3.00336071
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99395770
90spinal cord development (GO:0021510)2.98300519
91response to histamine (GO:0034776)2.96311075
92regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93351420
93regulation of neurotransmitter uptake (GO:0051580)2.92102406
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91946088
95presynaptic membrane organization (GO:0097090)2.91375481
96positive regulation of gastrulation (GO:2000543)2.91173188
97potassium ion homeostasis (GO:0055075)2.90682282
98regulation of amyloid precursor protein catabolic process (GO:1902991)2.90530370
99cerebellar granule cell differentiation (GO:0021707)2.90431548
100olfactory bulb development (GO:0021772)2.89995583
101central nervous system projection neuron axonogenesis (GO:0021952)2.88282980
102cilium movement (GO:0003341)2.87999801
103regulation of respiratory system process (GO:0044065)2.87945837
104neuromuscular synaptic transmission (GO:0007274)2.87588595
105positive regulation of alcohol biosynthetic process (GO:1902932)2.87314056
106cerebral cortex neuron differentiation (GO:0021895)2.86821818
107astrocyte differentiation (GO:0048708)2.86265182
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.83087308
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.82730538
110neuron fate determination (GO:0048664)2.81224945
111viral transcription (GO:0019083)2.79973012
112cerebral cortex radially oriented cell migration (GO:0021799)2.78726834
113adult walking behavior (GO:0007628)2.77791499
114regulation of cilium movement (GO:0003352)2.77593318
115negative regulation of axonogenesis (GO:0050771)2.77467802
116synaptic transmission, glutamatergic (GO:0035249)2.76143218
117protein localization to synapse (GO:0035418)2.75477057
118axoneme assembly (GO:0035082)2.74829332
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74233700
120positive regulation of oligodendrocyte differentiation (GO:0048714)2.73914718
121mechanosensory behavior (GO:0007638)2.72037708
122appendage development (GO:0048736)2.71575153
123limb development (GO:0060173)2.71575153
124regulation of development, heterochronic (GO:0040034)2.71362109
125regulation of oligodendrocyte differentiation (GO:0048713)2.70867564
126positive regulation of synapse assembly (GO:0051965)2.70427551
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70056236
128negative regulation of neurotransmitter secretion (GO:0046929)2.69690435
129positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66720706
130pattern specification involved in kidney development (GO:0061004)2.66242039
131regulation of microtubule-based movement (GO:0060632)2.65776806
132negative regulation of neurotransmitter transport (GO:0051589)2.65442396
133head development (GO:0060322)2.64854625
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64347966
135cranial nerve development (GO:0021545)2.64160109
136neuroblast proliferation (GO:0007405)2.63254677
137synapse organization (GO:0050808)2.63200197
138translational termination (GO:0006415)2.62471283
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62087099
140neuron migration (GO:0001764)2.61844568
141negative regulation of axon extension (GO:0030517)2.61315189
142L-glutamate transport (GO:0015813)2.60303776
143axon extension involved in axon guidance (GO:0048846)2.59842383
144neuron projection extension involved in neuron projection guidance (GO:1902284)2.59842383
145cell proliferation in forebrain (GO:0021846)2.59012396
146tongue development (GO:0043586)2.58781021
147neuronal action potential propagation (GO:0019227)2.58214434
148adenine nucleotide transport (GO:0051503)2.57472130
149limb bud formation (GO:0060174)2.56885787
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.56728151
151regulation of collateral sprouting (GO:0048670)2.55947207
152regulation of glutamate receptor signaling pathway (GO:1900449)2.55848698
153dendrite morphogenesis (GO:0048813)2.55344199
154axon extension (GO:0048675)2.54909871
155negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.53178221
156regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53065816
157positive regulation of dendritic spine development (GO:0060999)2.52775633
158nephron tubule formation (GO:0072079)2.52509133
159somite development (GO:0061053)2.51757310
160hippocampus development (GO:0021766)2.51643256
161prepulse inhibition (GO:0060134)2.51571226
162negative regulation of gliogenesis (GO:0014014)2.51143233
163long-term synaptic potentiation (GO:0060291)2.51014427
164response to cholesterol (GO:0070723)2.50281529
165photoreceptor cell differentiation (GO:0046530)2.49955342
166eye photoreceptor cell differentiation (GO:0001754)2.49955342
167cGMP-mediated signaling (GO:0019934)2.49902941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03596952
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30365626
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18664874
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.12793722
5GBX2_23144817_ChIP-Seq_PC3_Human3.12336322
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.01253699
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98364095
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.82627276
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76182221
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76169946
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76169946
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74261744
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.72296936
14AR_21572438_ChIP-Seq_LNCaP_Human2.59189932
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48997027
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.32368087
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26463422
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.20592246
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12757298
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.12637315
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09320589
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01520327
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96823659
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94987714
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94797142
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92909444
27* REST_21632747_ChIP-Seq_MESCs_Mouse1.92466596
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78614518
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75154561
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74455856
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72300814
32DROSHA_22980978_ChIP-Seq_HELA_Human1.68619878
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.67921959
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65076331
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63378034
36* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62537496
37P300_19829295_ChIP-Seq_ESCs_Human1.61969614
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60639093
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.58985898
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.57802814
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.55813513
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.45785032
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45184104
44SMAD4_21799915_ChIP-Seq_A2780_Human1.41279402
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.41247107
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40318282
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.39475383
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38334399
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34013985
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32429124
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32372353
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29662459
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29100556
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28455452
55IGF1R_20145208_ChIP-Seq_DFB_Human1.27923298
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26663124
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.26635819
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25944329
59TP53_18474530_ChIP-ChIP_U2OS_Human1.25758493
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24668454
61BCAT_22108803_ChIP-Seq_LS180_Human1.24663336
62AR_25329375_ChIP-Seq_VCAP_Human1.23376258
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22544194
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.22033955
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20066296
66RNF2_27304074_Chip-Seq_NSC_Mouse1.19462211
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.19317699
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18846581
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14410130
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14255727
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13620556
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13521281
73VDR_22108803_ChIP-Seq_LS180_Human1.12770817
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11804818
75FUS_26573619_Chip-Seq_HEK293_Human1.10925626
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10253940
77TAF15_26573619_Chip-Seq_HEK293_Human1.09815888
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06914071
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06092267
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05890130
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04955825
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.04795904
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04204112
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.02628128
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02484754
86AR_19668381_ChIP-Seq_PC3_Human1.01346150
87RUNX2_22187159_ChIP-Seq_PCA_Human1.00888793
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.00815858
89CTCF_27219007_Chip-Seq_Bcells_Human0.99873797
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98378670
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98378670
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98243230
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97814995
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96834153
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96587721
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96165706
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.96146738
98STAT3_23295773_ChIP-Seq_U87_Human0.95886087
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95658112
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95474546
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95371213
102* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95210695
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94922981
104* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94852220
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94247454
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93256425
107RXR_22108803_ChIP-Seq_LS180_Human0.93246898
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93148367
109TP53_16413492_ChIP-PET_HCT116_Human0.92540466
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92329749
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89728693
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.89587770
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89395025
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89268880
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.88772216
116HTT_18923047_ChIP-ChIP_STHdh_Human0.88576447
117IRF1_19129219_ChIP-ChIP_H3396_Human0.88061466
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.87461835
119POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86306300
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85709287
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85541015
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84928514
123ZNF274_21170338_ChIP-Seq_K562_Hela0.84448363
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.84349485
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84345813
126AHR_22903824_ChIP-Seq_MCF-7_Human0.84166316
127EWS_26573619_Chip-Seq_HEK293_Human0.83103752
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.82387775
129SOX9_26525672_Chip-Seq_HEART_Mouse0.81537656
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80056137
131WDR5_24793694_ChIP-Seq_LNCAP_Human0.79015220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003690_abnormal_glial_cell3.20455715
2MP0004859_abnormal_synaptic_plasticity3.16445623
3MP0004858_abnormal_nervous_system3.05473320
4MP0003136_yellow_coat_color3.03782994
5MP0005646_abnormal_pituitary_gland2.88739351
6MP0005423_abnormal_somatic_nervous2.86534474
7MP0001486_abnormal_startle_reflex2.74389026
8MP0003329_amyloid_beta_deposits2.69130167
9MP0004885_abnormal_endolymph2.60501176
10MP0003880_abnormal_central_pattern2.55472590
11MP0003635_abnormal_synaptic_transmissio2.55060652
12MP0003787_abnormal_imprinting2.54846072
13MP0004270_analgesia2.27250446
14MP0009745_abnormal_behavioral_response2.26926020
15MP0002064_seizures2.21370159
16MP0002572_abnormal_emotion/affect_behav2.19970468
17MP0009379_abnormal_foot_pigmentation2.18943318
18MP0001984_abnormal_olfaction2.14511548
19MP0009046_muscle_twitch2.14212477
20MP0002063_abnormal_learning/memory/cond2.13002687
21MP0002254_reproductive_system_inflammat2.12999208
22MP0001440_abnormal_grooming_behavior2.12262504
23MP0009384_cardiac_valve_regurgitation2.10899697
24MP0008789_abnormal_olfactory_epithelium2.08388700
25MP0005394_taste/olfaction_phenotype2.04774404
26MP0005499_abnormal_olfactory_system2.04774404
27MP0003878_abnormal_ear_physiology1.99855432
28MP0005377_hearing/vestibular/ear_phenot1.99855432
29MP0001502_abnormal_circadian_rhythm1.96068477
30MP0003634_abnormal_glial_cell1.92389888
31MP0002822_catalepsy1.92238452
32MP0002638_abnormal_pupillary_reflex1.82822640
33MP0001968_abnormal_touch/_nociception1.81916978
34MP0003122_maternal_imprinting1.78877605
35MP0001485_abnormal_pinna_reflex1.74814800
36MP0000778_abnormal_nervous_system1.74599884
37MP0003011_delayed_dark_adaptation1.74564444
38MP0004133_heterotaxia1.74093958
39MP0002736_abnormal_nociception_after1.72669514
40MP0002557_abnormal_social/conspecific_i1.71747544
41MP0002272_abnormal_nervous_system1.68478356
42MP0002733_abnormal_thermal_nociception1.62753884
43MP0006292_abnormal_olfactory_placode1.62335403
44MP0002734_abnormal_mechanical_nocicepti1.60110356
45MP0001905_abnormal_dopamine_level1.54437244
46MP0002067_abnormal_sensory_capabilities1.51442231
47MP0000049_abnormal_middle_ear1.50520769
48MP0001501_abnormal_sleep_pattern1.50145616
49MP0003121_genomic_imprinting1.50068476
50MP0005645_abnormal_hypothalamus_physiol1.45983077
51MP0000566_synostosis1.45774619
52MP0002653_abnormal_ependyma_morphology1.44732118
53MP0008569_lethality_at_weaning1.43405244
54MP0002249_abnormal_larynx_morphology1.42405526
55MP0009780_abnormal_chondrocyte_physiolo1.42365325
56MP0005551_abnormal_eye_electrophysiolog1.40601538
57MP0003123_paternal_imprinting1.39296197
58MP0005171_absent_coat_pigmentation1.39195661
59MP0005253_abnormal_eye_physiology1.35147436
60MP0003075_altered_response_to1.33927497
61MP0003633_abnormal_nervous_system1.33869142
62MP0002938_white_spotting1.32223045
63MP0003279_aneurysm1.31185433
64MP0006072_abnormal_retinal_apoptosis1.28482087
65MP0000026_abnormal_inner_ear1.28035114
66MP0001970_abnormal_pain_threshold1.27948768
67MP0003137_abnormal_impulse_conducting1.27599142
68MP0004924_abnormal_behavior1.27247404
69MP0005386_behavior/neurological_phenoty1.27247404
70MP0000604_amyloidosis1.26870140
71MP0002751_abnormal_autonomic_nervous1.26733236
72MP0004811_abnormal_neuron_physiology1.23768069
73MP0003861_abnormal_nervous_system1.22838684
74MP0004742_abnormal_vestibular_system1.22148607
75MP0001529_abnormal_vocalization1.21816259
76MP0003631_nervous_system_phenotype1.21579444
77MP0001293_anophthalmia1.19422419
78MP0002882_abnormal_neuron_morphology1.18548065
79MP0005379_endocrine/exocrine_gland_phen1.18363538
80MP0003632_abnormal_nervous_system1.18315304
81MP0006276_abnormal_autonomic_nervous1.16290787
82MP0004142_abnormal_muscle_tone1.14294325
83MP0001963_abnormal_hearing_physiology1.13716662
84MP0002127_abnormal_cardiovascular_syste1.12781349
85MP0003890_abnormal_embryonic-extraembry1.12226394
86MP0001986_abnormal_taste_sensitivity1.12202283
87MP0009250_abnormal_appendicular_skeleto1.11299913
88MP0002909_abnormal_adrenal_gland1.08591693
89MP0000631_abnormal_neuroendocrine_gland1.08146320
90MP0003938_abnormal_ear_development1.07713099
91MP0002152_abnormal_brain_morphology1.05010272
92MP0003119_abnormal_digestive_system1.04867536
93MP0002089_abnormal_postnatal_growth/wei1.03763101
94MP0002066_abnormal_motor_capabilities/c1.00192275
95MP0002184_abnormal_innervation0.98205140
96MP0002735_abnormal_chemical_nociception0.97978755
97MP0000920_abnormal_myelination0.96252994
98MP0002752_abnormal_somatic_nervous0.95240456
99MP0000955_abnormal_spinal_cord0.95017178
100MP0005167_abnormal_blood-brain_barrier0.94814253
101MP0005391_vision/eye_phenotype0.93635920
102MP0002090_abnormal_vision0.92986807
103MP0002928_abnormal_bile_duct0.89801949
104MP0001299_abnormal_eye_distance/0.89219918
105MP0001286_abnormal_eye_development0.88437711
106MP0002233_abnormal_nose_morphology0.88204943
107MP0000751_myopathy0.86642472
108MP0002163_abnormal_gland_morphology0.82766139
109MP0004215_abnormal_myocardial_fiber0.82494736
110MP0000462_abnormal_digestive_system0.81847859
111MP0003942_abnormal_urinary_system0.81394951
112MP0003755_abnormal_palate_morphology0.80472924
113MP0000534_abnormal_ureter_morphology0.80455052
114MP0001188_hyperpigmentation0.80019706
115MP0001853_heart_inflammation0.78106344
116MP0002229_neurodegeneration0.77489134
117MP0002697_abnormal_eye_size0.76358794
118MP0003879_abnormal_hair_cell0.75190874
119MP0005187_abnormal_penis_morphology0.73946432
120MP0005165_increased_susceptibility_to0.73600231
121MP0008877_abnormal_DNA_methylation0.73595717
122MP0002295_abnormal_pulmonary_circulatio0.73487606
123MP0005195_abnormal_posterior_eye0.73152599
124MP0005595_abnormal_vascular_smooth0.71332658
125MP0003385_abnormal_body_wall0.71069684
126MP0001958_emphysema0.67890818
127MP0005623_abnormal_meninges_morphology0.67628212
128MP0002102_abnormal_ear_morphology0.67414965
129MP0004134_abnormal_chest_morphology0.64328969
130MP0005332_abnormal_amino_acid0.63955805
131MP0010030_abnormal_orbit_morphology0.63581270

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)5.93931450
2Aplasia involving bones of the extremities (HP:0009825)5.93931450
3Aplasia involving bones of the upper limbs (HP:0009823)5.93931450
4Abnormality of the axillary hair (HP:0100134)4.82304294
5Abnormality of secondary sexual hair (HP:0009888)4.82304294
6Megalencephaly (HP:0001355)4.81886063
7Neurofibrillary tangles (HP:0002185)4.66039120
8Hemiparesis (HP:0001269)4.60889660
9Diplopia (HP:0000651)4.54735322
10Abnormality of binocular vision (HP:0011514)4.54735322
11Hypoplastic left heart (HP:0004383)4.11597772
12Focal motor seizures (HP:0011153)3.89702573
13Rib fusion (HP:0000902)3.89002388
14Abnormal ciliary motility (HP:0012262)3.84458128
15Hemiplegia (HP:0002301)3.57669662
16Abnormal respiratory motile cilium physiology (HP:0012261)3.53707486
17Cerebral inclusion bodies (HP:0100314)3.53093313
18Back pain (HP:0003418)3.32750801
19Septo-optic dysplasia (HP:0100842)3.31635074
20Humeroradial synostosis (HP:0003041)3.28853119
21Synostosis involving the elbow (HP:0003938)3.28853119
22Hepatoblastoma (HP:0002884)3.22810000
23Anomalous pulmonary venous return (HP:0010772)3.20988339
24Hypoplastic heart (HP:0001961)3.19769499
25Clumsiness (HP:0002312)3.08598244
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02090674
27Molar tooth sign on MRI (HP:0002419)2.99684785
28Abnormality of midbrain morphology (HP:0002418)2.99684785
29Abnormal respiratory epithelium morphology (HP:0012253)2.94157915
30Abnormal respiratory motile cilium morphology (HP:0005938)2.94157915
31Epileptic encephalopathy (HP:0200134)2.92440783
32Nephronophthisis (HP:0000090)2.87465710
33Myokymia (HP:0002411)2.84166885
34Abnormality of the dental pulp (HP:0006479)2.79610550
35Abnormality of the pulmonary veins (HP:0011718)2.74358175
36Absent hair (HP:0002298)2.73298164
37Mixed hearing impairment (HP:0000410)2.70129114
38Short hallux (HP:0010109)2.67306451
39Supranuclear gaze palsy (HP:0000605)2.65831925
40Fibular aplasia (HP:0002990)2.64642194
41Cortical dysplasia (HP:0002539)2.58688501
42Confusion (HP:0001289)2.58376343
43Anophthalmia (HP:0000528)2.57477467
44Onycholysis (HP:0001806)2.56360781
45Absent/shortened dynein arms (HP:0200106)2.55328748
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.55328748
47Limb dystonia (HP:0002451)2.54562963
48Rhinitis (HP:0012384)2.53624169
49Narrow nasal bridge (HP:0000446)2.51005405
50Abnormality of the middle phalanges of the toes (HP:0010183)2.41443811
51Optic nerve hypoplasia (HP:0000609)2.41424623
52Pancreatic cysts (HP:0001737)2.38838053
53Abnormality of the 4th metacarpal (HP:0010012)2.38409543
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.34514930
55Abnormality of the labia minora (HP:0012880)2.33120093
56Focal seizures (HP:0007359)2.32980840
57Hyperventilation (HP:0002883)2.31871663
58Abnormality of the renal medulla (HP:0100957)2.29546284
59Sclerocornea (HP:0000647)2.29195634
60Split foot (HP:0001839)2.28159391
61Abnormality of the diencephalon (HP:0010662)2.27542056
62Retinal dysplasia (HP:0007973)2.25985494
63Growth hormone deficiency (HP:0000824)2.24619229
64Partial duplication of thumb phalanx (HP:0009944)2.21605535
65Neonatal short-limb short stature (HP:0008921)2.20733587
66Supernumerary spleens (HP:0009799)2.19894604
67Occipital encephalocele (HP:0002085)2.19297663
68Oligodactyly (HP:0012165)2.18641813
69Absent septum pellucidum (HP:0001331)2.18603398
70Chronic hepatic failure (HP:0100626)2.17467198
71Adactyly (HP:0009776)2.16767567
72Polyphagia (HP:0002591)2.14184366
73Anencephaly (HP:0002323)2.13313542
74Drooling (HP:0002307)2.12719039
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12411196
76Abnormality of the dental root (HP:0006486)2.12374571
77Taurodontia (HP:0000679)2.12374571
78Abnormality of permanent molar morphology (HP:0011071)2.12374571
79Poor coordination (HP:0002370)2.12233048
80Potter facies (HP:0002009)2.10337638
81Facial shape deformation (HP:0011334)2.10337638
82Specific learning disability (HP:0001328)2.08767995
83Generalized tonic-clonic seizures (HP:0002069)2.08106666
84Abnormality of molar morphology (HP:0011070)2.07265130
85Abnormality of molar (HP:0011077)2.07265130
86Esophageal atresia (HP:0002032)2.07205757
87Postaxial hand polydactyly (HP:0001162)2.06546086
88Long nose (HP:0003189)2.06076121
89Mesangial abnormality (HP:0001966)2.04968675
90Hypoplasia of the brainstem (HP:0002365)2.04459886
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04459886
92Type II lissencephaly (HP:0007260)2.04087835
93Symphalangism affecting the phalanges of the hand (HP:0009773)2.03927861
94Abnormality of the corticospinal tract (HP:0002492)2.03428165
95Abnormality of cells of the erythroid lineage (HP:0012130)2.02661377
96Anterior segment dysgenesis (HP:0007700)2.02273856
97Poor suck (HP:0002033)2.01887958
98Hemivertebrae (HP:0002937)2.01870189
99Medial flaring of the eyebrow (HP:0010747)2.01003338
100Postaxial foot polydactyly (HP:0001830)2.00924316
101Vitreoretinal degeneration (HP:0000655)2.00220778
102Pachygyria (HP:0001302)2.00140890
103Reticulocytopenia (HP:0001896)1.99128937
104Hyperglycinuria (HP:0003108)1.98356388
105Aplasia/Hypoplasia of the fibula (HP:0006492)1.97947769
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97406802
107Short 4th metacarpal (HP:0010044)1.97406802
108Gait imbalance (HP:0002141)1.97388664
109Cystic liver disease (HP:0006706)1.96530562
110True hermaphroditism (HP:0010459)1.95711108
111Bronchomalacia (HP:0002780)1.95670846
112Lissencephaly (HP:0001339)1.95476367
113Maternal diabetes (HP:0009800)1.93797691
114Partial duplication of the phalanx of hand (HP:0009999)1.93336231
115Morphological abnormality of the inner ear (HP:0011390)1.91415687
116Renal hypoplasia (HP:0000089)1.91300878
117Intestinal atresia (HP:0011100)1.90274747
118Renal dysplasia (HP:0000110)1.89609825
119Aplasia/hypoplasia of the uterus (HP:0008684)1.89574220
120Abnormality of nail color (HP:0100643)1.89435886
121Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88588735
122Excessive salivation (HP:0003781)1.88028631
123Adrenal hypoplasia (HP:0000835)1.87381119
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.87130407
125Abnormal eating behavior (HP:0100738)1.85969905
126Optic nerve coloboma (HP:0000588)1.83669111
127Congenital primary aphakia (HP:0007707)1.82178827
128Hyperglycinemia (HP:0002154)1.81441301
129Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80779389
130Amblyopia (HP:0000646)1.79949499
131Fibular hypoplasia (HP:0003038)1.79721963
132Status epilepticus (HP:0002133)1.79177070
133Meningocele (HP:0002435)1.78430998
134Cerebellar dysplasia (HP:0007033)1.77729816
135Action tremor (HP:0002345)1.77145218
136Alacrima (HP:0000522)1.76389041
137Abnormal number of erythroid precursors (HP:0012131)1.75364652
138Median cleft lip (HP:0000161)1.74653083
139Nasolacrimal duct obstruction (HP:0000579)1.74270165
140Asplenia (HP:0001746)1.74180509
141Coronal craniosynostosis (HP:0004440)1.73117632
142Sleep apnea (HP:0010535)1.71397659
143Narrow forehead (HP:0000341)1.70577881
144Dysdiadochokinesis (HP:0002075)1.69641371
145Abnormality of the phalanges of the 5th finger (HP:0004213)1.69639453
146Progressive cerebellar ataxia (HP:0002073)1.69305492
147Gastrointestinal atresia (HP:0002589)1.69231639
148Pseudobulbar signs (HP:0002200)1.69182312
149Anosmia (HP:0000458)1.68987932
150Tubular atrophy (HP:0000092)1.68562068
151Abnormality of the lower motor neuron (HP:0002366)1.67473865
152Abnormal sex determination (HP:0012244)1.67220936
153Sex reversal (HP:0012245)1.67220936
154Oligodactyly (hands) (HP:0001180)1.65586426
155Abnormal drinking behavior (HP:0030082)1.65362101
156Polydipsia (HP:0001959)1.65362101
157Recurrent corneal erosions (HP:0000495)1.65019882
158Broad foot (HP:0001769)1.64822935
159Short middle phalanx of the 5th finger (HP:0004220)1.64106617
160Abnormal urine output (HP:0012590)1.63637894
161Abnormality of glycine metabolism (HP:0010895)1.63561399
162Abnormality of serine family amino acid metabolism (HP:0010894)1.63561399
163Abnormality of the lacrimal duct (HP:0011481)1.63273087
164Vaginal atresia (HP:0000148)1.60610914
165Genital tract atresia (HP:0001827)1.60211984
166Nephrogenic diabetes insipidus (HP:0009806)1.60200770
167Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59322672
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.59269224
169Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58674373
170Amelogenesis imperfecta (HP:0000705)1.58274560
171Pancreatic fibrosis (HP:0100732)1.57867871
172Brittle hair (HP:0002299)1.56630147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.21130174
2CASK4.07000303
3NTRK23.91367768
4LMTK23.81516363
5TNIK3.62790674
6PHKG23.15294619
7PHKG13.15294619
8MUSK2.88217070
9NTRK32.28796432
10MAPK132.22910892
11MARK12.08505137
12DYRK31.87493735
13PINK11.82980770
14WNK41.82406537
15DYRK1B1.76952949
16SIK11.63449759
17PRKD31.60892794
18MAP2K71.56029364
19SGK21.53924652
20MAPK121.52988506
21SGK4941.49620334
22SGK2231.49620334
23ADRBK11.47078669
24CSNK1G21.45236348
25FGR1.38394723
26PRKCG1.32002506
27MAP3K41.30627398
28BCR1.27252087
29MINK11.27184630
30BCKDK1.27074081
31GRK51.19352121
32FGFR21.18362102
33PNCK1.15389213
34DYRK1A1.15138537
35CDK51.09572575
36EPHA31.09159506
37CDK31.09007707
38CCNB11.06770882
39MAPK151.06708523
40GRK61.06424612
41CAMK2A1.05324695
42CSNK1G31.03616399
43ROCK11.01379451
44INSRR1.01227450
45PLK21.01028188
46ERBB20.97147628
47WNK30.96515767
48PRKCE0.95769913
49WEE10.94040388
50CSNK1A1L0.93861116
51ADRBK20.92280415
52MAPK70.90965753
53SGK30.89961318
54MAP4K20.89054877
55PRPF4B0.87924275
56OXSR10.87639400
57BRAF0.86158511
58SIK20.84304206
59LIMK10.83981790
60PAK30.82757532
61CSNK1G10.82481095
62KSR10.80780638
63ROCK20.80607664
64PKN10.79870800
65GRK70.79725707
66SIK30.79558258
67PAK60.78947138
68PTK2B0.77406284
69MST40.77319441
70NTRK10.76863968
71BMPR1B0.75527170
72DDR20.72159113
73STK110.68032197
74NME10.67717489
75CAMK2B0.67547020
76MAP3K90.64856658
77STK160.64311534
78ARAF0.63250639
79PRKACA0.62312921
80CAMKK10.59646477
81MKNK20.58472699
82UHMK10.57142057
83CDK150.56773259
84CDK180.56735834
85FES0.55618455
86TYRO30.55561096
87MAP2K40.55278796
88CAMK2G0.54667375
89PRKCZ0.54498285
90SGK10.54044632
91GRK10.53995459
92DAPK20.53876434
93DYRK20.53033989
94PRKCA0.52055468
95PRKCH0.51957897
96ERBB40.51801078
97MAPK40.51621985
98CAMK1G0.51116566
99STK240.51056060
100PIM20.50538070
101PRKG10.49406338
102CDK140.48360740
103ICK0.47485784
104RPS6KA20.47271847
105TNK20.47233252
106NEK60.47064714
107CDK11A0.46485230
108CDC42BPA0.45662102
109LRRK20.45168508
110YES10.45088632
111CAMK10.45029239
112PRKACG0.43893505
113IGF1R0.42267678
114MARK20.41731788
115RPS6KA30.41608298
116IRAK20.41222060
117CSNK1E0.41182502
118PRKCQ0.41039947
119PRKD20.40569850
120MYLK0.40380765
121WNK10.39205150
122CDK190.37243802
123CAMK2D0.36793966
124ERBB30.36761080
125CAMK1D0.35782196
126FYN0.35267942
127STK390.35113406
128BMPR20.34880377
129PRKACB0.34404068
130CSNK1D0.34311149
131TSSK60.34096854
132EPHB20.33048992
133CSNK1A10.32788741
134AKT20.32702949
135PIK3CA0.31757287
136CAMK40.31273696

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.37185258
2Nitrogen metabolism_Homo sapiens_hsa009104.34403359
3Nicotine addiction_Homo sapiens_hsa050333.20318164
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.18119143
5Ribosome_Homo sapiens_hsa030102.66314658
6GABAergic synapse_Homo sapiens_hsa047272.30013820
7Glutamatergic synapse_Homo sapiens_hsa047242.18713169
8Fatty acid metabolism_Homo sapiens_hsa012122.15241393
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13381676
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00422137
11Notch signaling pathway_Homo sapiens_hsa043301.98309019
12Salivary secretion_Homo sapiens_hsa049701.94421957
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79963489
14Steroid biosynthesis_Homo sapiens_hsa001001.75213829
15Circadian entrainment_Homo sapiens_hsa047131.70816413
16Morphine addiction_Homo sapiens_hsa050321.67349043
17Gastric acid secretion_Homo sapiens_hsa049711.66706430
18Insulin secretion_Homo sapiens_hsa049111.66394876
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65083926
20Fatty acid degradation_Homo sapiens_hsa000711.59594254
21PPAR signaling pathway_Homo sapiens_hsa033201.47938727
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44514727
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38124094
24Cocaine addiction_Homo sapiens_hsa050301.36553435
25Oxidative phosphorylation_Homo sapiens_hsa001901.34793258
26Calcium signaling pathway_Homo sapiens_hsa040201.30707863
27Fatty acid elongation_Homo sapiens_hsa000621.27878720
28Hippo signaling pathway_Homo sapiens_hsa043901.26296909
29Taste transduction_Homo sapiens_hsa047421.24827197
30Olfactory transduction_Homo sapiens_hsa047401.24464248
31Amphetamine addiction_Homo sapiens_hsa050311.23699302
32Renin secretion_Homo sapiens_hsa049241.22744769
33Serotonergic synapse_Homo sapiens_hsa047261.15511962
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14155215
35Cardiac muscle contraction_Homo sapiens_hsa042601.12234960
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11827655
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10847006
38Basal cell carcinoma_Homo sapiens_hsa052171.10771114
39Long-term potentiation_Homo sapiens_hsa047201.10720673
40Ether lipid metabolism_Homo sapiens_hsa005651.07424535
41Propanoate metabolism_Homo sapiens_hsa006401.07019441
42Butanoate metabolism_Homo sapiens_hsa006501.05727272
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03911170
44Bile secretion_Homo sapiens_hsa049761.03461467
45Alzheimers disease_Homo sapiens_hsa050101.02725733
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01446362
47Melanogenesis_Homo sapiens_hsa049161.01048994
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00352768
49Circadian rhythm_Homo sapiens_hsa047100.99757278
50Synaptic vesicle cycle_Homo sapiens_hsa047210.99003730
51Mineral absorption_Homo sapiens_hsa049780.97766766
52Axon guidance_Homo sapiens_hsa043600.97393369
53cAMP signaling pathway_Homo sapiens_hsa040240.94482832
54Long-term depression_Homo sapiens_hsa047300.94226440
55Hedgehog signaling pathway_Homo sapiens_hsa043400.91889461
56Parkinsons disease_Homo sapiens_hsa050120.91273483
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90454852
58Dopaminergic synapse_Homo sapiens_hsa047280.87400220
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86549349
60Pancreatic secretion_Homo sapiens_hsa049720.86266862
61Gap junction_Homo sapiens_hsa045400.84676686
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84001529
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83498424
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82425072
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81865818
66Cholinergic synapse_Homo sapiens_hsa047250.80240347
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77805742
68Protein export_Homo sapiens_hsa030600.77017988
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76749106
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76537711
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76524437
72African trypanosomiasis_Homo sapiens_hsa051430.73262013
73Dorso-ventral axis formation_Homo sapiens_hsa043200.73178730
74Huntingtons disease_Homo sapiens_hsa050160.72299355
75Alcoholism_Homo sapiens_hsa050340.72197687
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71774059
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69387660
78Sulfur metabolism_Homo sapiens_hsa009200.69109267
79Thyroid hormone synthesis_Homo sapiens_hsa049180.68986317
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68292087
81Peroxisome_Homo sapiens_hsa041460.67746173
82Linoleic acid metabolism_Homo sapiens_hsa005910.66140380
83beta-Alanine metabolism_Homo sapiens_hsa004100.65345440
84Dilated cardiomyopathy_Homo sapiens_hsa054140.63291356
85Wnt signaling pathway_Homo sapiens_hsa043100.62644194
86Oxytocin signaling pathway_Homo sapiens_hsa049210.60650489
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.59364961
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58999562
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58785753
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.58546179
91Arginine and proline metabolism_Homo sapiens_hsa003300.58241727
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.54558849
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54421939
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52658037
95Regulation of autophagy_Homo sapiens_hsa041400.48805237
96Collecting duct acid secretion_Homo sapiens_hsa049660.48725996
97Sphingolipid metabolism_Homo sapiens_hsa006000.48273854
98GnRH signaling pathway_Homo sapiens_hsa049120.47520794
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47105855
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.47017067
101Glycerolipid metabolism_Homo sapiens_hsa005610.46281029
102ErbB signaling pathway_Homo sapiens_hsa040120.45590379
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44740648
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.44546765
105Phototransduction_Homo sapiens_hsa047440.44315997
106Basal transcription factors_Homo sapiens_hsa030220.43935524
107Estrogen signaling pathway_Homo sapiens_hsa049150.43422600
108Tight junction_Homo sapiens_hsa045300.41196743
109Fructose and mannose metabolism_Homo sapiens_hsa000510.40500798
110MAPK signaling pathway_Homo sapiens_hsa040100.39545028
111Ovarian steroidogenesis_Homo sapiens_hsa049130.38974999
112Glucagon signaling pathway_Homo sapiens_hsa049220.38087193
113Colorectal cancer_Homo sapiens_hsa052100.37449976
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.37284416
115RNA polymerase_Homo sapiens_hsa030200.36599048
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36484809
117Histidine metabolism_Homo sapiens_hsa003400.35836884
118Tryptophan metabolism_Homo sapiens_hsa003800.35460540
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35193886
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34799181
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34334776
122Sulfur relay system_Homo sapiens_hsa041220.33838789
123Vitamin digestion and absorption_Homo sapiens_hsa049770.33736240
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32104765
125Ras signaling pathway_Homo sapiens_hsa040140.31944847
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31000061
127Rap1 signaling pathway_Homo sapiens_hsa040150.30731520

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