NIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50394271
2L-phenylalanine catabolic process (GO:0006559)7.50394271
3L-phenylalanine metabolic process (GO:0006558)7.27048939
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27048939
5aromatic amino acid family catabolic process (GO:0009074)6.74288772
6glyoxylate metabolic process (GO:0046487)6.25041998
7DNA deamination (GO:0045006)6.16729185
8tryptophan catabolic process (GO:0006569)6.09786121
9indole-containing compound catabolic process (GO:0042436)6.09786121
10indolalkylamine catabolic process (GO:0046218)6.09786121
11tryptophan metabolic process (GO:0006568)5.76193143
12cysteine metabolic process (GO:0006534)5.74037992
13kynurenine metabolic process (GO:0070189)5.73499703
14bile acid biosynthetic process (GO:0006699)5.59215631
15lysine metabolic process (GO:0006553)5.43145926
16lysine catabolic process (GO:0006554)5.43145926
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.37752222
18sulfur amino acid catabolic process (GO:0000098)5.30709474
19serine family amino acid catabolic process (GO:0009071)5.23553777
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19295446
21cytidine metabolic process (GO:0046087)5.15681716
22cytidine catabolic process (GO:0006216)5.15681716
23cytidine deamination (GO:0009972)5.15681716
24urea metabolic process (GO:0019627)5.12828279
25urea cycle (GO:0000050)5.12828279
26homocysteine metabolic process (GO:0050667)5.09175540
27alpha-linolenic acid metabolic process (GO:0036109)5.04151914
28aromatic amino acid family metabolic process (GO:0009072)4.97560850
29high-density lipoprotein particle remodeling (GO:0034375)4.85645394
30amino-acid betaine metabolic process (GO:0006577)4.83090934
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.81492431
32bile acid metabolic process (GO:0008206)4.79454176
33nitrogen cycle metabolic process (GO:0071941)4.75673280
34alpha-amino acid catabolic process (GO:1901606)4.70920518
35negative regulation of fibrinolysis (GO:0051918)4.68634923
36water-soluble vitamin biosynthetic process (GO:0042364)4.66949009
37urate metabolic process (GO:0046415)4.62321011
38peptidyl-glutamic acid carboxylation (GO:0017187)4.61484295
39protein carboxylation (GO:0018214)4.61484295
40tyrosine metabolic process (GO:0006570)4.59262570
41drug transmembrane transport (GO:0006855)4.57154486
42regulation of fibrinolysis (GO:0051917)4.52285875
43drug catabolic process (GO:0042737)4.51737325
44regulation of protein activation cascade (GO:2000257)4.46202062
45cellular ketone body metabolic process (GO:0046950)4.45749478
46complement activation, alternative pathway (GO:0006957)4.43511559
47cellular amino acid catabolic process (GO:0009063)4.41515286
48pyrimidine ribonucleoside catabolic process (GO:0046133)4.41475562
49serine family amino acid metabolic process (GO:0009069)4.40660908
50indolalkylamine metabolic process (GO:0006586)4.39228831
51regulation of triglyceride catabolic process (GO:0010896)4.38890778
52coenzyme catabolic process (GO:0009109)4.30209750
53amine catabolic process (GO:0009310)4.29471241
54cellular biogenic amine catabolic process (GO:0042402)4.29471241
55triglyceride homeostasis (GO:0070328)4.28272087
56acylglycerol homeostasis (GO:0055090)4.28272087
57reverse cholesterol transport (GO:0043691)4.26875187
58cellular modified amino acid catabolic process (GO:0042219)4.26740467
59alkaloid metabolic process (GO:0009820)4.26456547
60regulation of cholesterol esterification (GO:0010872)4.24078032
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.19991483
62glycine metabolic process (GO:0006544)4.19893154
63cellular glucuronidation (GO:0052695)4.18447429
64glutamate metabolic process (GO:0006536)4.17448934
65regulation of complement activation (GO:0030449)4.15833938
66serine family amino acid biosynthetic process (GO:0009070)4.13981494
67benzene-containing compound metabolic process (GO:0042537)4.13011786
68cellular anion homeostasis (GO:0030002)4.11904786
69short-chain fatty acid metabolic process (GO:0046459)4.09785700
70exogenous drug catabolic process (GO:0042738)4.08861915
71protein-lipid complex remodeling (GO:0034368)4.08128013
72macromolecular complex remodeling (GO:0034367)4.08128013
73plasma lipoprotein particle remodeling (GO:0034369)4.08128013
74protein complex biogenesis (GO:0070271)4.07820312
75epoxygenase P450 pathway (GO:0019373)4.06452209
76negative regulation of sterol transport (GO:0032372)4.03377812
77negative regulation of cholesterol transport (GO:0032375)4.03377812
78aspartate family amino acid catabolic process (GO:0009068)4.01131850
79imidazole-containing compound metabolic process (GO:0052803)3.97640865
80organic acid catabolic process (GO:0016054)3.96513739
81carboxylic acid catabolic process (GO:0046395)3.96513739
82respiratory chain complex IV assembly (GO:0008535)3.95312097
83cytochrome complex assembly (GO:0017004)3.94669459
84bile acid and bile salt transport (GO:0015721)3.91123355
85ethanol oxidation (GO:0006069)3.90891058
86drug transport (GO:0015893)3.89374938
87valine metabolic process (GO:0006573)3.87416071
88ATP synthesis coupled proton transport (GO:0015986)3.87197023
89energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87197023
90phospholipid efflux (GO:0033700)3.86084996
912-oxoglutarate metabolic process (GO:0006103)3.86064045
92fatty acid beta-oxidation (GO:0006635)3.85393543
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84868240
94ketone body metabolic process (GO:1902224)3.83435942
95aldehyde catabolic process (GO:0046185)3.82272924
96chaperone-mediated protein transport (GO:0072321)3.81938829
97uronic acid metabolic process (GO:0006063)3.81166883
98glucuronate metabolic process (GO:0019585)3.81166883
99acetyl-CoA metabolic process (GO:0006084)3.78311922
100fatty acid oxidation (GO:0019395)3.77837302
101arginine metabolic process (GO:0006525)3.74756500
102plasma lipoprotein particle clearance (GO:0034381)3.73191860
103monocarboxylic acid catabolic process (GO:0072329)3.73134401
104mitochondrial respiratory chain complex assembly (GO:0033108)3.72404946
105carnitine metabolic process (GO:0009437)3.72331310
106lipid oxidation (GO:0034440)3.70170030
107fatty acid catabolic process (GO:0009062)3.66816253
108oxidative demethylation (GO:0070989)3.65948047
109regulation of bile acid biosynthetic process (GO:0070857)3.63938877
110dicarboxylic acid biosynthetic process (GO:0043650)3.63813061
111branched-chain amino acid catabolic process (GO:0009083)3.62605275
112positive regulation of triglyceride lipase activity (GO:0061365)3.61353958
113positive regulation of lipoprotein lipase activity (GO:0051006)3.61353958
114cholesterol efflux (GO:0033344)3.59371805
115mitochondrial respiratory chain complex I assembly (GO:0032981)3.56418137
116NADH dehydrogenase complex assembly (GO:0010257)3.56418137
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56418137
118branched-chain amino acid metabolic process (GO:0009081)3.55046082
119vitamin biosynthetic process (GO:0009110)3.53083405
120fructose metabolic process (GO:0006000)3.51621577
121cofactor catabolic process (GO:0051187)3.50283503
122regulation of cholesterol homeostasis (GO:2000188)3.49933394
123response to misfolded protein (GO:0051788)3.49459621
124drug metabolic process (GO:0017144)3.49349077
125cholesterol homeostasis (GO:0042632)3.48141552
126respiratory electron transport chain (GO:0022904)3.45359458
127electron transport chain (GO:0022900)3.42264332
128behavioral response to nicotine (GO:0035095)3.35811005
129omega-hydroxylase P450 pathway (GO:0097267)3.33888530
130platelet dense granule organization (GO:0060155)3.27935740
131positive regulation of cell fate commitment (GO:0010455)3.06674470
132secondary heart field specification (GO:0003139)3.04729218
133heart field specification (GO:0003128)3.04729218
134negative regulation of telomere maintenance (GO:0032205)3.04642659
135pyrimidine nucleoside catabolic process (GO:0046135)3.04353669
136preassembly of GPI anchor in ER membrane (GO:0016254)3.01443935
137hydrogen peroxide biosynthetic process (GO:0050665)2.98051460
138negative regulation of cell fate specification (GO:0009996)2.93250965
139GPI anchor biosynthetic process (GO:0006506)2.92684719
140fucose catabolic process (GO:0019317)2.92678570
141L-fucose metabolic process (GO:0042354)2.92678570
142L-fucose catabolic process (GO:0042355)2.92678570
143xenobiotic catabolic process (GO:0042178)2.91592148
144phenylpropanoid metabolic process (GO:0009698)2.91502556
145protein neddylation (GO:0045116)2.87300850
146intracellular pH reduction (GO:0051452)2.86813335
147GPI anchor metabolic process (GO:0006505)2.83912609
148adaptation of signaling pathway (GO:0023058)2.80299048
149quinone biosynthetic process (GO:1901663)2.79689976
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.79010169
151epithelial cilium movement (GO:0003351)2.78543757
152sulfation (GO:0051923)2.75801720
153rRNA modification (GO:0000154)2.74486138
154positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74458558
155reactive oxygen species biosynthetic process (GO:1903409)2.72049248
156regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.71871312
157S-adenosylmethionine metabolic process (GO:0046500)2.70978208
158C-terminal protein lipidation (GO:0006501)2.66727833
159glutathione derivative metabolic process (GO:1901685)2.66453480
160glutathione derivative biosynthetic process (GO:1901687)2.66453480
161protein-cofactor linkage (GO:0018065)2.64862694
162positive regulation of defense response to virus by host (GO:0002230)2.63985141
163DNA catabolic process, exonucleolytic (GO:0000738)2.58605103
164rRNA methylation (GO:0031167)2.58049967
165hydrogen ion transmembrane transport (GO:1902600)2.55904533
166mannosylation (GO:0097502)2.54876979
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52794058
168protein deneddylation (GO:0000338)2.52064659
169somite rostral/caudal axis specification (GO:0032525)2.51682858
170regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51058433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.99979123
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.94618725
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.58277434
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.18049421
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.11219584
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06105381
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03012484
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02754797
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80351165
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67630064
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66466219
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.34191731
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02869673
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.95008271
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82964517
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79153688
17ZNF274_21170338_ChIP-Seq_K562_Hela2.41594165
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35171889
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32347023
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.30220389
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19290419
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15137269
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09598141
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4279288
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94211929
26VDR_22108803_ChIP-Seq_LS180_Human1.94035916
27VDR_23849224_ChIP-Seq_CD4+_Human1.92743930
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76499508
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.67263778
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59455795
31FOXP3_21729870_ChIP-Seq_TREG_Human1.56755234
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55736772
33* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53284610
34CLOCK_20551151_ChIP-Seq_293T_Human1.51784778
35HTT_18923047_ChIP-ChIP_STHdh_Human1.50032228
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49457370
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49023533
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.48253295
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45539256
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44920165
41ELK1_19687146_ChIP-ChIP_HELA_Human1.44207322
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.42882583
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42809039
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.41618264
45NANOG_20526341_ChIP-Seq_ESCs_Human1.41122423
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39386237
47ERA_21632823_ChIP-Seq_H3396_Human1.36228991
48TP53_22573176_ChIP-Seq_HFKS_Human1.34134684
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33839418
50E2F1_20622854_ChIP-Seq_HELA_Human1.33489600
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31925588
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.30996700
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.30749164
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30649455
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.29913505
56XRN2_22483619_ChIP-Seq_HELA_Human1.28437968
57MYC_19829295_ChIP-Seq_ESCs_Human1.27933531
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.27567234
59IGF1R_20145208_ChIP-Seq_DFB_Human1.27217913
60MYC_18940864_ChIP-ChIP_HL60_Human1.25910605
61BCL6_27268052_Chip-Seq_Bcells_Human1.25004835
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22027934
63GATA1_22025678_ChIP-Seq_K562_Human1.22024632
64GABP_19822575_ChIP-Seq_HepG2_Human1.21841008
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.20455666
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20455666
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19792180
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18772552
69CTCF_20526341_ChIP-Seq_ESCs_Human1.16361624
70ERG_20517297_ChIP-Seq_VCAP_Human1.15610057
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.13635374
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.12721528
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10635575
74* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10618004
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10030381
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07779536
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07377559
78KDM5A_27292631_Chip-Seq_BREAST_Human1.06939270
79* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05972575
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05936401
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05560282
82BCOR_27268052_Chip-Seq_Bcells_Human1.04778261
83SA1_27219007_Chip-Seq_Bcells_Human1.02125557
84DCP1A_22483619_ChIP-Seq_HELA_Human0.99896182
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99821457
86GATA4_25053715_ChIP-Seq_YYC3_Human0.99727174
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99422691
88PHF8_20622854_ChIP-Seq_HELA_Human0.99028857
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98455710
90P300_27268052_Chip-Seq_Bcells_Human0.98196930
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98039503
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97743132
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97368725
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97286857
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96707452
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96494381
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96493635
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96112078
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.95354190
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94654189
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.94162163
102HOXB7_26014856_ChIP-Seq_BT474_Human0.92548278
103* GATA6_21074721_ChIP-Seq_CACO-2_Human0.91940045
104* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91634280
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88455742
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85846973
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85270960
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81673517
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.81321851
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79694388
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78823184
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78050980
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.77929888
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75544764
115AR_20517297_ChIP-Seq_VCAP_Human0.75367132
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73792203
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71693005
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.71406646
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70500672
120STAT1_17558387_ChIP-Seq_HELA_Human0.69695044
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69357030
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.66668685
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66552970
124IRF1_19129219_ChIP-ChIP_H3396_Human0.65475236
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.63911778
126CEBPB_22108803_ChIP-Seq_LS180_Human0.63239605
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62455352
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62344480
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59651735
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.58081341
131MYC_19915707_ChIP-ChIP_AK7_Human0.57470422
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57137892
133EGR1_19032775_ChIP-ChIP_M12_Human0.56364346
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.56363764
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.56250728
136TAF2_19829295_ChIP-Seq_ESCs_Human0.55735401
137CBP_21632823_ChIP-Seq_H3396_Human0.55542917
138TAF15_26573619_Chip-Seq_HEK293_Human0.54937672
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54795159
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.54271210
141P53_21459846_ChIP-Seq_SAOS-2_Human0.53782924
142* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53652716
143* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.53244802
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52134808
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.51705532
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.50707770
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.50067820
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.49887836
149* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.49521992
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.49503469
151* CRX_20693478_ChIP-Seq_RETINA_Mouse0.49452045
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.49261410
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.48907900
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47728631
155GATA6_25053715_ChIP-Seq_YYC3_Human0.47248514
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47090670
157OCT4_20526341_ChIP-Seq_ESCs_Human0.46717826
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46693489
159SOX2_22085726_ChIP-Seq_NPCs_Mouse0.46651891
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.45678656
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.45107990
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.45107990
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.44939956
164OCT4_21477851_ChIP-Seq_ESCs_Mouse0.44422415
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.43780256
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.43148357
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.42642574
168LXR_22292898_ChIP-Seq_THP-1_Human0.42621818
169NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42549811
170P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.42091794
171SOX2_20726797_ChIP-Seq_SW620_Human0.41588069
172SOX2_18692474_ChIP-Seq_MEFs_Mouse0.41122991
173NCOR_22424771_ChIP-Seq_293T_Human0.40771766
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40557474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20418090
2MP0005360_urolithiasis7.62366813
3MP0005085_abnormal_gallbladder_physiolo5.97303256
4MP0005365_abnormal_bile_salt5.86067478
5MP0008875_abnormal_xenobiotic_pharmacok4.99185614
6MP0003806_abnormal_nucleotide_metabolis4.00668360
7MP0003252_abnormal_bile_duct3.84475906
8MP0005332_abnormal_amino_acid3.33981237
9MP0010329_abnormal_lipoprotein_level3.25880161
10MP0003195_calcinosis3.08033866
11MP0009840_abnormal_foam_cell2.81514489
12MP0005083_abnormal_biliary_tract2.75103515
13MP0004019_abnormal_vitamin_homeostasis2.72754148
14MP0001666_abnormal_nutrient_absorption2.68177928
15MP0002234_abnormal_pharynx_morphology2.57256147
16MP0001986_abnormal_taste_sensitivity2.50380096
17MP0002138_abnormal_hepatobiliary_system2.48102936
18MP0003191_abnormal_cellular_cholesterol2.22556440
19MP0001873_stomach_inflammation2.13186879
20MP0002118_abnormal_lipid_homeostasis2.04973909
21MP0002653_abnormal_ependyma_morphology2.04716039
22MP0000609_abnormal_liver_physiology1.94706758
23MP0001764_abnormal_homeostasis1.85226828
24MP0009643_abnormal_urine_homeostasis1.82374033
25MP0005319_abnormal_enzyme/_coenzyme1.78106534
26MP0005451_abnormal_body_composition1.74072760
27MP0003868_abnormal_feces_composition1.67373869
28MP0002638_abnormal_pupillary_reflex1.66290114
29MP0005584_abnormal_enzyme/coenzyme_acti1.60996503
30MP0003186_abnormal_redox_activity1.52847393
31MP0009785_altered_susceptibility_to1.48331450
32MP0009697_abnormal_copulation1.46968875
33MP0005636_abnormal_mineral_homeostasis1.46757922
34MP0005551_abnormal_eye_electrophysiolog1.45441761
35MP0003136_yellow_coat_color1.42874634
36MP0003011_delayed_dark_adaptation1.41598876
37MP0004043_abnormal_pH_regulation1.39574601
38MP0002277_abnormal_respiratory_mucosa1.38632519
39MP0005645_abnormal_hypothalamus_physiol1.26435101
40MP0005084_abnormal_gallbladder_morpholo1.23278599
41MP0008877_abnormal_DNA_methylation1.23274861
42MP0006082_CNS_inflammation1.21295958
43MP0002938_white_spotting1.21121097
44MP0002876_abnormal_thyroid_physiology1.21096885
45MP0006036_abnormal_mitochondrial_physio1.19836733
46MP0008058_abnormal_DNA_repair1.18801616
47MP0005670_abnormal_white_adipose1.15795720
48MP0002102_abnormal_ear_morphology1.15314658
49MP0005671_abnormal_response_to1.14956917
50MP0001756_abnormal_urination1.14701377
51MP0006072_abnormal_retinal_apoptosis1.13019862
52MP0005647_abnormal_sex_gland1.11609521
53MP0005253_abnormal_eye_physiology1.10556631
54MP0005423_abnormal_somatic_nervous1.10240079
55MP0000598_abnormal_liver_morphology1.05471207
56MP0001968_abnormal_touch/_nociception1.04119518
57MP0001485_abnormal_pinna_reflex1.03399778
58MP0004133_heterotaxia1.03278992
59MP0003436_decreased_susceptibility_to1.03108505
60MP0001663_abnormal_digestive_system1.03061505
61MP0008995_early_reproductive_senescence1.02195705
62MP0008789_abnormal_olfactory_epithelium1.02104038
63MP0002148_abnormal_hypersensitivity_rea1.02002893
64MP0005220_abnormal_exocrine_pancreas1.00010997
65MP0001529_abnormal_vocalization0.99384822
66MP0006292_abnormal_olfactory_placode0.99195167
67MP0006276_abnormal_autonomic_nervous0.98718663
68MP0003656_abnormal_erythrocyte_physiolo0.98329175
69MP0000372_irregular_coat_pigmentation0.97587297
70MP0004142_abnormal_muscle_tone0.96130424
71MP0009764_decreased_sensitivity_to0.95499151
72MP0005646_abnormal_pituitary_gland0.95327748
73MP0002693_abnormal_pancreas_physiology0.94041491
74MP0005025_abnormal_response_to0.93853638
75MP0001919_abnormal_reproductive_system0.93196023
76MP0009642_abnormal_blood_homeostasis0.90995045
77MP0001765_abnormal_ion_homeostasis0.89651660
78MP0002736_abnormal_nociception_after0.89156407
79MP0005408_hypopigmentation0.88772255
80MP0002136_abnormal_kidney_physiology0.88526395
81MP0002909_abnormal_adrenal_gland0.86041927
82MP0002078_abnormal_glucose_homeostasis0.83395339
83MP0005174_abnormal_tail_pigmentation0.82658395
84MP0008469_abnormal_protein_level0.80767749
85MP0001661_extended_life_span0.80690979
86MP0009763_increased_sensitivity_to0.79645410
87MP0009765_abnormal_xenobiotic_induced0.77932236
88MP0000604_amyloidosis0.77841844
89MP0003879_abnormal_hair_cell0.77607312
90MP0002254_reproductive_system_inflammat0.76645219
91MP0003880_abnormal_central_pattern0.75379945
92MP0000343_altered_response_to0.74492293
93MP0002928_abnormal_bile_duct0.74220650
94MP0003878_abnormal_ear_physiology0.74217103
95MP0005377_hearing/vestibular/ear_phenot0.74217103
96MP0001800_abnormal_humoral_immune0.74162204
97MP0001905_abnormal_dopamine_level0.73237385
98MP0005376_homeostasis/metabolism_phenot0.72796930
99MP0005535_abnormal_body_temperature0.72712080
100MP0002419_abnormal_innate_immunity0.70534168
101MP0006035_abnormal_mitochondrial_morpho0.69829332
102MP0005334_abnormal_fat_pad0.68661274
103MP0000685_abnormal_immune_system0.68307714
104MP0003718_maternal_effect0.67902916
105MP0005195_abnormal_posterior_eye0.67860277
106MP0005379_endocrine/exocrine_gland_phen0.67291181
107MP0002971_abnormal_brown_adipose0.67185107
108MP0002132_abnormal_respiratory_system0.65215728
109MP0002837_dystrophic_cardiac_calcinosis0.64010051
110MP0005666_abnormal_adipose_tissue0.62035881
111MP0003329_amyloid_beta_deposits0.61965689
112MP0004130_abnormal_muscle_cell0.61286501
113MP0010368_abnormal_lymphatic_system0.59174906
114MP0005266_abnormal_metabolism0.56455538
115MP0004264_abnormal_extraembryonic_tissu0.55314365
116MP0005395_other_phenotype0.54441332
117MP0000230_abnormal_systemic_arterial0.53493618
118MP0004147_increased_porphyrin_level0.53087444
119MP0004782_abnormal_surfactant_physiolog0.53036918
120MP0000538_abnormal_urinary_bladder0.52413769
121MP0003724_increased_susceptibility_to0.51637051
122MP0003953_abnormal_hormone_level0.51575932
123MP0002796_impaired_skin_barrier0.51003809
124MP0003638_abnormal_response/metabolism_0.50544947
125MP0008872_abnormal_physiological_respon0.48361011
126MP0004381_abnormal_hair_follicle0.48176180
127MP0005058_abnormal_lysosome_morphology0.48113896
128MP0000639_abnormal_adrenal_gland0.47582977
129MP0005448_abnormal_energy_balance0.45183342
130MP0009053_abnormal_anal_canal0.43856596
131MP0003690_abnormal_glial_cell0.41350613
132MP0001944_abnormal_pancreas_morphology0.38692246
133MP0003705_abnormal_hypodermis_morpholog0.38038323
134MP0002135_abnormal_kidney_morphology0.36876995
135MP0009672_abnormal_birth_weight0.33537681
136MP0003959_abnormal_lean_body0.32956824
137MP0010234_abnormal_vibrissa_follicle0.30190041
138MP0008874_decreased_physiological_sensi0.29693810
139MP0000678_abnormal_parathyroid_gland0.29292080
140MP0002168_other_aberrant_phenotype0.28414358
141MP0002822_catalepsy0.27042823
142MP0005166_decreased_susceptibility_to0.25560507
143MP0000579_abnormal_nail_morphology0.24336758
144MP0009384_cardiac_valve_regurgitation0.23826512
145MP0001845_abnormal_inflammatory_respons0.23756012
146MP0002970_abnormal_white_adipose0.23334764
147MP0001881_abnormal_mammary_gland0.22700517
148* MP0008873_increased_physiological_sensi0.22452614
149MP0002098_abnormal_vibrissa_morphology0.20918590
150MP0002269_muscular_atrophy0.20620437

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01191959
2Intrahepatic cholestasis (HP:0001406)6.36209717
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.82725144
4Deep venous thrombosis (HP:0002625)5.73756708
5Prolonged partial thromboplastin time (HP:0003645)5.53728504
6Xanthomatosis (HP:0000991)5.49058135
7Hypobetalipoproteinemia (HP:0003563)5.28654479
8Hyperglycinuria (HP:0003108)4.94313184
9Hyperglycinemia (HP:0002154)4.89369100
10Abnormality of glycine metabolism (HP:0010895)4.65293989
11Abnormality of serine family amino acid metabolism (HP:0010894)4.65293989
12Hyperlipoproteinemia (HP:0010980)4.64861366
13Hyperammonemia (HP:0001987)4.63508144
14Ketosis (HP:0001946)4.62017263
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52375521
16Complement deficiency (HP:0004431)4.23515968
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19000543
18Joint hemorrhage (HP:0005261)4.13587938
19Gout (HP:0001997)4.11727642
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.09745552
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05241681
22Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05241681
23Mitochondrial inheritance (HP:0001427)4.03179017
24Abnormality of fatty-acid metabolism (HP:0004359)3.97567540
25Hypolipoproteinemia (HP:0010981)3.96821139
26Acute necrotizing encephalopathy (HP:0006965)3.96137780
27Hypoglycemic coma (HP:0001325)3.90966541
28Abnormality of methionine metabolism (HP:0010901)3.83624368
29Acute encephalopathy (HP:0006846)3.76809285
30Ketoacidosis (HP:0001993)3.71925317
31Increased IgM level (HP:0003496)3.71117836
32Fat malabsorption (HP:0002630)3.70435203
33Autoimmune thrombocytopenia (HP:0001973)3.69460797
34Epidermoid cyst (HP:0200040)3.66968703
35Increased CSF lactate (HP:0002490)3.66740426
36Abnormal mitochondria in muscle tissue (HP:0008316)3.65439219
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.63730297
38Increased hepatocellular lipid droplets (HP:0006565)3.61453758
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.58504260
40Hepatocellular necrosis (HP:0001404)3.56566492
41Abnormality of the common coagulation pathway (HP:0010990)3.53006436
42Abnormality of purine metabolism (HP:0004352)3.49096965
43Abnormality of nucleobase metabolism (HP:0010932)3.49083836
44Abnormality of pyrimidine metabolism (HP:0004353)3.49057577
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48155363
46Generalized aminoaciduria (HP:0002909)3.47849724
47Hypoalphalipoproteinemia (HP:0003233)3.45961623
48Lipid accumulation in hepatocytes (HP:0006561)3.45205330
49Hepatic necrosis (HP:0002605)3.43493795
50Abnormality of the intrinsic pathway (HP:0010989)3.43229166
513-Methylglutaconic aciduria (HP:0003535)3.42890524
52Delayed CNS myelination (HP:0002188)3.39577746
53Progressive macrocephaly (HP:0004481)3.32293316
54Abnormality of serum amino acid levels (HP:0003112)3.32131890
55Conjugated hyperbilirubinemia (HP:0002908)3.30323125
56Renal Fanconi syndrome (HP:0001994)3.25797486
57Dicarboxylic aciduria (HP:0003215)3.18546040
58Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18546040
59Metabolic acidosis (HP:0001942)3.14479261
60Hyperbilirubinemia (HP:0002904)3.09631778
61Lethargy (HP:0001254)3.07523759
62Abnormality of complement system (HP:0005339)2.95250111
63Proximal tubulopathy (HP:0000114)2.94671140
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88543464
65Hypercholesterolemia (HP:0003124)2.83308691
66Increased purine levels (HP:0004368)2.80882151
67Hyperuricemia (HP:0002149)2.80882151
68Steatorrhea (HP:0002570)2.80228273
69Methylmalonic acidemia (HP:0002912)2.73925839
70Alkalosis (HP:0001948)2.71429939
71Abnormality of urine glucose concentration (HP:0011016)2.71374446
72Glycosuria (HP:0003076)2.71374446
73Lactic acidosis (HP:0003128)2.70220505
74Increased intramyocellular lipid droplets (HP:0012240)2.68976343
75Autoimmune hemolytic anemia (HP:0001890)2.67813736
76Vascular calcification (HP:0004934)2.66203152
77Hypochromic anemia (HP:0001931)2.66039453
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63193412
79Cerebral edema (HP:0002181)2.60981938
80Exertional dyspnea (HP:0002875)2.58139988
81Enlarged kidneys (HP:0000105)2.56266801
82Late onset (HP:0003584)2.55651721
83Respiratory failure (HP:0002878)2.53681900
84Birth length less than 3rd percentile (HP:0003561)2.53340256
85Hepatocellular carcinoma (HP:0001402)2.52687697
86Irritability (HP:0000737)2.51882641
87Hypoglycemic seizures (HP:0002173)2.50213859
88Increased muscle lipid content (HP:0009058)2.49860793
89Neutropenia (HP:0001875)2.48573315
90Vomiting (HP:0002013)2.47651269
91Malnutrition (HP:0004395)2.46997621
92Neonatal onset (HP:0003623)2.39336664
93Type 2 muscle fiber atrophy (HP:0003554)2.36313645
94Enlarged epiphyses (HP:0010580)2.34929525
95Increased serum lactate (HP:0002151)2.33284407
96Pancreatitis (HP:0001733)2.29026787
97Cardiovascular calcification (HP:0011915)2.26708190
98Molar tooth sign on MRI (HP:0002419)2.26631809
99Abnormality of midbrain morphology (HP:0002418)2.26631809
100Medial flaring of the eyebrow (HP:0010747)2.25700695
101Reticulocytopenia (HP:0001896)2.24953611
102Renal cortical cysts (HP:0000803)2.23222893
103Spontaneous abortion (HP:0005268)2.22163373
104Rickets (HP:0002748)2.19916488
105Opisthotonus (HP:0002179)2.19701367
106Skin nodule (HP:0200036)2.19630909
107Abnormality of renal resorption (HP:0011038)2.17216703
108Abnormality of proline metabolism (HP:0010907)2.17074699
109Hydroxyprolinuria (HP:0003080)2.17074699
110Abnormality of vitamin B metabolism (HP:0004340)2.15719853
111Brushfield spots (HP:0001088)2.15304854
112Systemic lupus erythematosus (HP:0002725)2.14604539
113Sensorimotor neuropathy (HP:0007141)2.14130098
114Eosinophilia (HP:0001880)2.14064427
115Petechiae (HP:0000967)2.13609059
116Spastic diplegia (HP:0001264)2.13498806
117Hyperinsulinemic hypoglycemia (HP:0000825)2.13286909
118Myocardial infarction (HP:0001658)2.12257240
119Neonatal hypoglycemia (HP:0001998)2.11826090
120Optic disc pallor (HP:0000543)2.11334662
121Pancreatic cysts (HP:0001737)2.09664658
122Abnormal gallbladder morphology (HP:0012437)2.06994340
123Acanthocytosis (HP:0001927)2.05988075
124Hypochromic microcytic anemia (HP:0004840)2.04731302
125Symptomatic seizures (HP:0011145)2.04352553
126Muscle fiber atrophy (HP:0100295)2.03323256
127Attenuation of retinal blood vessels (HP:0007843)2.03200342
128Abnormal enzyme/coenzyme activity (HP:0012379)2.02609165
129Exercise intolerance (HP:0003546)2.02507240
130Cholecystitis (HP:0001082)2.00342107
131Abnormal gallbladder physiology (HP:0012438)2.00342107
132True hermaphroditism (HP:0010459)2.00309816
133Cholelithiasis (HP:0001081)1.97791541
134Type I transferrin isoform profile (HP:0003642)1.95231937
135Hyperphosphaturia (HP:0003109)1.95192052
136Nephronophthisis (HP:0000090)1.94468404
137Abolished electroretinogram (ERG) (HP:0000550)1.94199959
138Abnormal number of erythroid precursors (HP:0012131)1.92981617
139CNS demyelination (HP:0007305)1.92633570
140Abnormality of vitamin metabolism (HP:0100508)1.91269269
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.90839423
142Abnormal albumin level (HP:0012116)1.90706578
143Hypoalbuminemia (HP:0003073)1.90706578
144Methylmalonic aciduria (HP:0012120)1.90187671
145Hypophosphatemic rickets (HP:0004912)1.88315352
146Nephrolithiasis (HP:0000787)1.87055090
147Depressed nasal tip (HP:0000437)1.85763766
148Abnormality of the gallbladder (HP:0005264)1.85549526
149Pancreatic fibrosis (HP:0100732)1.85546786
150Menorrhagia (HP:0000132)1.85147824
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85076078
152Abnormal urine phosphate concentration (HP:0012599)1.85035847
153Hyperglycemia (HP:0003074)1.84251419
154Reduced antithrombin III activity (HP:0001976)1.83919207
155Hyperactive renin-angiotensin system (HP:0000841)1.83650721
156Decreased central vision (HP:0007663)1.83406751
157Abnormality of T cell physiology (HP:0011840)1.82991815
158Nausea (HP:0002018)1.82736910
159Abnormality of alkaline phosphatase activity (HP:0004379)1.80882217
160Elevated hepatic transaminases (HP:0002910)1.80620448
161Glomerulonephritis (HP:0000099)1.80055044
162Esophageal varix (HP:0002040)1.78911460
163Congenital, generalized hypertrichosis (HP:0004540)1.78825283
164Congenital stationary night blindness (HP:0007642)1.78278879
165Abnormal pupillary function (HP:0007686)1.75314564
166Lip pit (HP:0100267)1.74785033
167Granulocytopenia (HP:0001913)1.73471691
168Pendular nystagmus (HP:0012043)1.73181020
169Polydipsia (HP:0001959)1.72330603
170Abnormal drinking behavior (HP:0030082)1.72330603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.52907197
2TLK17.06670448
3PIK3CA3.70831497
4FGFR43.45701092
5WNK43.38066620
6WNK33.26436061
7ERN13.17135577
8ZAK3.07658179
9SIK12.95740484
10MAP4K22.76986514
11CDK192.68084006
12VRK22.61821790
13INSRR2.58967008
14OXSR12.41712760
15ERBB42.38155230
16TAOK32.24556245
17STK38L2.17219138
18MST1R2.16219301
19ADRBK22.15252118
20MAP3K31.96718668
21PDK31.84583900
22PDK41.84583900
23TXK1.77434269
24MAPK151.76564117
25FLT31.73181524
26PDK21.63085300
27MAP2K41.59370002
28AKT31.57994896
29MAPK111.54009756
30FRK1.47642253
31IRAK31.43078677
32PIK3CG1.41791841
33PINK11.40268295
34VRK11.38966950
35MAP2K31.38175273
36MUSK1.34886952
37NEK91.31620819
38MAP4K11.26829794
39BMPR1B1.26784138
40BLK1.24529341
41NUAK11.24443610
42SGK4941.23889129
43SGK2231.23889129
44STK391.20093426
45SGK21.19370201
46TNK21.19261236
47IRAK11.17833471
48PRKAA21.16855537
49IRAK21.14029236
50ABL21.11879519
51PKN21.09538546
52ACVR1B1.09264475
53EPHA21.08741683
54IKBKB1.07107107
55KIT1.06407825
56BUB11.06009415
57TRIM281.03418021
58MAPKAPK31.02486132
59PTK61.01241794
60CSNK1G31.00779217
61DYRK21.00064202
62TESK10.96680782
63CAMKK20.96147917
64NME10.94402793
65GRK70.93710454
66SGK30.92618537
67TYK20.92448880
68PIM20.90163817
69TGFBR20.87629862
70TIE10.85172884
71DYRK1B0.83862194
72CSNK1G20.83807924
73TNIK0.83012211
74GSK3A0.81982393
75MAP3K60.81055591
76MAPK130.80333712
77TRIB30.79123850
78TBK10.78409455
79MAP2K60.78176632
80ADRBK10.76751672
81TESK20.75365003
82STK160.74946215
83MAP3K70.74797285
84MYLK0.74719902
85CAMK2G0.73981879
86PRKCZ0.73301932
87BRAF0.72549186
88JAK20.71695597
89MST40.70399260
90MET0.69706612
91CCNB10.69655294
92PRKAA10.69615418
93GRK50.69213785
94BMPR20.68955914
95PRPF4B0.68675145
96EPHA30.64691705
97MAP3K140.63299522
98MAP2K70.62837910
99CASK0.61974460
100MAPK40.61101400
101ERBB20.60978971
102CSNK1A1L0.60698400
103MAP3K110.60449682
104GRK60.58843290
105TAF10.58753016
106PRKACG0.57692369
107FGFR20.57173716
108SYK0.56614579
109STK380.55881213
110KDR0.54456075
111MARK30.53778829
112STK100.52738068
113MAP2K20.52374306
114LATS10.52298201
115DAPK20.52183621
116LYN0.51916410
117PKN10.50698940
118IKBKE0.49974881
119PTK20.48314105
120PDPK10.45883216
121CSNK1G10.45528287
122STK110.44554969
123PLK30.44362123
124LCK0.43627816
125EIF2AK10.43125616
126NEK10.42003084
127MAP3K40.40473393
128BTK0.40324949
129RPS6KA50.39947500
130SIK30.39387911
131ZAP700.39358817
132CAMK1D0.38223290
133DAPK30.37425220
134LIMK10.37240144
135MAP3K10.36344488
136PAK30.35350113
137IRAK40.34911959
138EPHA40.34492409
139PRKCI0.34167315
140PRKCE0.34069748
141PLK10.33969214
142FER0.33954030
143NLK0.33901066
144MAP3K50.33219097
145ITK0.31813532
146IGF1R0.31482160
147PRKCG0.31368575
148MATK0.31338229
149EPHB20.30564696
150JAK10.30444176
151CSNK2A10.30158349
152RET0.30004737
153GRK10.29795523
154PRKCA0.29602363
155CSNK1A10.28774640
156PLK40.28753246
157MAPK120.28725039
158CSK0.28156337
159PDK10.27515177
160DYRK30.27254133
161EIF2AK30.26888859
162MAP2K10.26528899
163JAK30.25559214
164PRKACA0.23733555
165CDK60.21545042
166PRKCQ0.21408286

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98854818
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29105541
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02665487
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83960084
5Nitrogen metabolism_Homo sapiens_hsa009102.83646857
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68786314
7Tryptophan metabolism_Homo sapiens_hsa003802.68148428
8Arginine biosynthesis_Homo sapiens_hsa002202.65283725
9Fatty acid degradation_Homo sapiens_hsa000712.61673856
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56378388
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52354582
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43109324
13Butanoate metabolism_Homo sapiens_hsa006502.38672634
14Propanoate metabolism_Homo sapiens_hsa006402.32674628
15Peroxisome_Homo sapiens_hsa041462.24809221
16Complement and coagulation cascades_Homo sapiens_hsa046102.21943582
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05930401
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00327487
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89839667
20Proteasome_Homo sapiens_hsa030501.89691518
21Histidine metabolism_Homo sapiens_hsa003401.86788391
22Fatty acid metabolism_Homo sapiens_hsa012121.86671644
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.84565997
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82476426
25beta-Alanine metabolism_Homo sapiens_hsa004101.81362427
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77920536
27PPAR signaling pathway_Homo sapiens_hsa033201.76323455
28Chemical carcinogenesis_Homo sapiens_hsa052041.75900723
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73974849
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70946776
31Pyruvate metabolism_Homo sapiens_hsa006201.69550659
32Selenocompound metabolism_Homo sapiens_hsa004501.68966801
33Retinol metabolism_Homo sapiens_hsa008301.61582048
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.61148427
35Sulfur metabolism_Homo sapiens_hsa009201.55190875
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54050037
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.53165955
38Phenylalanine metabolism_Homo sapiens_hsa003601.51879565
39Type I diabetes mellitus_Homo sapiens_hsa049401.49033916
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47787813
41Folate biosynthesis_Homo sapiens_hsa007901.43712987
42Starch and sucrose metabolism_Homo sapiens_hsa005001.41382097
43RNA polymerase_Homo sapiens_hsa030201.38133260
44Bile secretion_Homo sapiens_hsa049761.37816970
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.35664639
46Carbon metabolism_Homo sapiens_hsa012001.35463675
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35269827
48Fatty acid elongation_Homo sapiens_hsa000621.34657129
49Allograft rejection_Homo sapiens_hsa053301.33523966
50Huntingtons disease_Homo sapiens_hsa050161.33323744
51Graft-versus-host disease_Homo sapiens_hsa053321.31543562
52Tyrosine metabolism_Homo sapiens_hsa003501.31485755
53Caffeine metabolism_Homo sapiens_hsa002321.29181786
54Alzheimers disease_Homo sapiens_hsa050101.28923591
55Autoimmune thyroid disease_Homo sapiens_hsa053201.28347329
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.28038412
57Biosynthesis of amino acids_Homo sapiens_hsa012301.24783164
58Vitamin digestion and absorption_Homo sapiens_hsa049771.22512495
59Staphylococcus aureus infection_Homo sapiens_hsa051501.20771106
60Ribosome_Homo sapiens_hsa030101.17170775
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13363122
62Homologous recombination_Homo sapiens_hsa034401.12644719
63Steroid biosynthesis_Homo sapiens_hsa001001.11492690
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09473036
65ABC transporters_Homo sapiens_hsa020101.08318933
66Fat digestion and absorption_Homo sapiens_hsa049751.08038639
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06691470
68Arginine and proline metabolism_Homo sapiens_hsa003301.06201841
69Sulfur relay system_Homo sapiens_hsa041221.04661260
70Vitamin B6 metabolism_Homo sapiens_hsa007501.03073567
71African trypanosomiasis_Homo sapiens_hsa051431.02895249
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01242867
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95537569
74Glutathione metabolism_Homo sapiens_hsa004800.93905490
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91492728
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89385853
77Glycerolipid metabolism_Homo sapiens_hsa005610.80809912
78Pentose phosphate pathway_Homo sapiens_hsa000300.79783036
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77724770
80Lysine degradation_Homo sapiens_hsa003100.72790769
81One carbon pool by folate_Homo sapiens_hsa006700.68336938
82Fanconi anemia pathway_Homo sapiens_hsa034600.64970804
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63860068
84Fructose and mannose metabolism_Homo sapiens_hsa000510.61878046
85Phototransduction_Homo sapiens_hsa047440.60279767
86Metabolic pathways_Homo sapiens_hsa011000.59887481
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.55946790
88Rheumatoid arthritis_Homo sapiens_hsa053230.55138074
89Ether lipid metabolism_Homo sapiens_hsa005650.51496403
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48938359
91Galactose metabolism_Homo sapiens_hsa000520.48770098
92Primary immunodeficiency_Homo sapiens_hsa053400.47284506
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44435484
94Cardiac muscle contraction_Homo sapiens_hsa042600.43945457
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29234034
96Fatty acid biosynthesis_Homo sapiens_hsa000610.27539478
97Linoleic acid metabolism_Homo sapiens_hsa005910.20890142
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18203490
99Regulation of autophagy_Homo sapiens_hsa041400.17928032
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16149828
101Prion diseases_Homo sapiens_hsa050200.16001020
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.15688719
103Insulin resistance_Homo sapiens_hsa049310.13506383
104Glucagon signaling pathway_Homo sapiens_hsa049220.12880940
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.12878081
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10906109
107Other glycan degradation_Homo sapiens_hsa005110.06212529
108Oxidative phosphorylation_Homo sapiens_hsa001900.05910651
109Arachidonic acid metabolism_Homo sapiens_hsa005900.04605499
110AMPK signaling pathway_Homo sapiens_hsa041520.00876634
111Hepatitis C_Homo sapiens_hsa05160-0.1841736
112Pyrimidine metabolism_Homo sapiens_hsa00240-0.1708161
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1642074
114Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1537917
115Lysosome_Homo sapiens_hsa04142-0.1463983
116Insulin signaling pathway_Homo sapiens_hsa04910-0.1279582
117Renin-angiotensin system_Homo sapiens_hsa04614-0.0959842
118Parkinsons disease_Homo sapiens_hsa05012-0.0843272
119Collecting duct acid secretion_Homo sapiens_hsa04966-0.0803822
120Mineral absorption_Homo sapiens_hsa04978-0.0715407
121Protein digestion and absorption_Homo sapiens_hsa04974-0.0661524
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0658674
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0650929
124Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0259999
125Protein export_Homo sapiens_hsa03060-0.0090486

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