NISCH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.09948430
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07272423
3cerebellar granule cell differentiation (GO:0021707)3.97687914
4synaptic vesicle maturation (GO:0016188)3.79224306
5locomotory exploration behavior (GO:0035641)3.78575968
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.69539527
7cell communication by electrical coupling (GO:0010644)3.59062788
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57853895
9establishment of nucleus localization (GO:0040023)3.44681741
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.41007168
11regulation of synapse maturation (GO:0090128)3.38873679
12sodium ion export (GO:0071436)3.38203659
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35747354
14L-amino acid import (GO:0043092)3.27581515
15establishment of mitochondrion localization (GO:0051654)3.24613479
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21407348
17mannose metabolic process (GO:0006013)3.19576347
18negative regulation of erythrocyte differentiation (GO:0045647)3.18913790
19mitochondrion transport along microtubule (GO:0047497)3.18576015
20establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.18576015
21insulin-like growth factor receptor signaling pathway (GO:0048009)3.12964334
22cerebellar Purkinje cell layer development (GO:0021680)3.10347168
23axonal fasciculation (GO:0007413)3.08685389
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.08014838
25Golgi transport vesicle coating (GO:0048200)3.07106876
26COPI coating of Golgi vesicle (GO:0048205)3.07106876
27dendritic spine morphogenesis (GO:0060997)3.02816059
28amino acid import (GO:0043090)3.02497409
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.01077396
30postsynaptic membrane organization (GO:0001941)3.00725271
31dendrite morphogenesis (GO:0048813)2.98529338
32G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98098855
33peptidyl-tyrosine autophosphorylation (GO:0038083)2.94338775
34positive regulation of membrane potential (GO:0045838)2.90757575
35neurotransmitter-gated ion channel clustering (GO:0072578)2.88868147
36activation of protein kinase A activity (GO:0034199)2.86936246
37regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82998504
38cell migration in hindbrain (GO:0021535)2.80962330
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80954043
40planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80583713
41innervation (GO:0060384)2.77720563
42dopamine receptor signaling pathway (GO:0007212)2.77166290
43positive regulation of Rap GTPase activity (GO:0032854)2.77068392
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77009902
45stress granule assembly (GO:0034063)2.76239412
46positive regulation of synapse maturation (GO:0090129)2.75104536
47neuron projection extension involved in neuron projection guidance (GO:1902284)2.74050790
48axon extension involved in axon guidance (GO:0048846)2.74050790
49regulation of synaptic plasticity (GO:0048167)2.73309715
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72449789
51regulation of synapse structural plasticity (GO:0051823)2.71617978
52plasma membrane repair (GO:0001778)2.70934861
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69441762
54auditory behavior (GO:0031223)2.68844823
55regulation of synaptic vesicle exocytosis (GO:2000300)2.67528077
56negative regulation of catenin import into nucleus (GO:0035414)2.67312899
57exploration behavior (GO:0035640)2.66097222
58polarized epithelial cell differentiation (GO:0030859)2.65271337
59neurotransmitter transport (GO:0006836)2.64166956
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64110854
61cellular response to monoamine stimulus (GO:0071868)2.63976714
62cellular response to catecholamine stimulus (GO:0071870)2.63976714
63neuron recognition (GO:0008038)2.63111997
64cerebellar Purkinje cell differentiation (GO:0021702)2.63106138
65regulation of vesicle fusion (GO:0031338)2.62554542
66positive regulation of dendritic spine development (GO:0060999)2.61920361
67neuromuscular process controlling posture (GO:0050884)2.61137413
68regulation of glutamate receptor signaling pathway (GO:1900449)2.59351056
69cell differentiation in hindbrain (GO:0021533)2.58886723
70long-term memory (GO:0007616)2.58729194
71synaptic vesicle exocytosis (GO:0016079)2.56593817
72regulation of axon extension involved in axon guidance (GO:0048841)2.54845583
73response to pheromone (GO:0019236)2.54606080
74regulation of Rap GTPase activity (GO:0032317)2.54543187
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54103232
76camera-type eye morphogenesis (GO:0048593)2.53582131
77cellular potassium ion homeostasis (GO:0030007)2.53278153
78glutamate secretion (GO:0014047)2.53071669
79membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52205221
80regulation of NFAT protein import into nucleus (GO:0051532)2.52200020
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51804939
82pre-miRNA processing (GO:0031054)2.51354771
83synaptic transmission, glutamatergic (GO:0035249)2.51242361
84regulation of neurotransmitter secretion (GO:0046928)2.51057060
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50095090
86neuromuscular process controlling balance (GO:0050885)2.48087885
87neuronal action potential propagation (GO:0019227)2.46866094
88vocalization behavior (GO:0071625)2.46514317
89cell junction maintenance (GO:0034331)2.46242236
90positive regulation of dendrite development (GO:1900006)2.46055954
91positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44630838
92peptidyl-lysine dimethylation (GO:0018027)2.44469965
93proline transport (GO:0015824)2.43847441
94embryonic foregut morphogenesis (GO:0048617)2.43625068
95negative regulation of cell size (GO:0045792)2.42890727
96central nervous system projection neuron axonogenesis (GO:0021952)2.41335058
97regulation of postsynaptic membrane potential (GO:0060078)2.40817163
98neuron cell-cell adhesion (GO:0007158)2.40266235
99cell communication involved in cardiac conduction (GO:0086065)2.40064827
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39721906
101central nervous system myelination (GO:0022010)2.39675819
102axon ensheathment in central nervous system (GO:0032291)2.39675819
103regulation of neuronal synaptic plasticity (GO:0048168)2.39672958
104positive regulation of dendrite morphogenesis (GO:0050775)2.39588962
105synaptic vesicle endocytosis (GO:0048488)2.39264002
106positive regulation of glycogen biosynthetic process (GO:0045725)2.38960277
107regulation of axon guidance (GO:1902667)2.38808482
108positive regulation of neurotransmitter transport (GO:0051590)2.38634597
109regulation of neurotransmitter levels (GO:0001505)2.38090733
110neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35739522
111regulation of ARF protein signal transduction (GO:0032012)2.33474505
112membrane repolarization during action potential (GO:0086011)2.32704202
113protein targeting to plasma membrane (GO:0072661)2.32500424
114glucocorticoid receptor signaling pathway (GO:0042921)2.31532565
115semaphorin-plexin signaling pathway (GO:0071526)2.31451168
116dendritic spine organization (GO:0097061)2.30798749
117glial cell proliferation (GO:0014009)2.30375433
118cytoplasmic mRNA processing body assembly (GO:0033962)2.29724843
119suckling behavior (GO:0001967)2.29595470
120collecting duct development (GO:0072044)2.29510550
121neurotransmitter secretion (GO:0007269)2.29409153
122growth hormone secretion (GO:0030252)2.29229456
123epithelial cell fate commitment (GO:0072148)2.28066134
124membrane repolarization (GO:0086009)2.28008633
125negative regulation of axonogenesis (GO:0050771)2.27897192
126regulation of synaptic vesicle transport (GO:1902803)2.26984118
127establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.26695437
128nucleus localization (GO:0051647)2.26599851
129heart morphogenesis (GO:0003007)2.26492338
130neuronal ion channel clustering (GO:0045161)2.25044134
131regulation of axonogenesis (GO:0050770)2.24565574
132body morphogenesis (GO:0010171)2.24421211
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.24343619
134peripheral nervous system axon ensheathment (GO:0032292)2.23704736
135myelination in peripheral nervous system (GO:0022011)2.23704736
136signal complex assembly (GO:0007172)2.23623676
137positive regulation of synaptic transmission, GABAergic (GO:0032230)2.23431467
138ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.22541331
139vesicle transport along microtubule (GO:0047496)2.21614626
140adherens junction assembly (GO:0034333)2.21315039
141axon extension (GO:0048675)2.20393399
142regulation of ARF GTPase activity (GO:0032312)2.19580061
143mating behavior (GO:0007617)2.19088826
144regulation of establishment of planar polarity (GO:0090175)2.19025750
145cardiac myofibril assembly (GO:0055003)2.18327508
146gastrulation with mouth forming second (GO:0001702)2.17267717
147hippo signaling (GO:0035329)2.17093193
148positive regulation of axon extension (GO:0045773)2.16883747
149cell-cell junction maintenance (GO:0045217)2.16605374
150cellular sodium ion homeostasis (GO:0006883)2.16157762
151potassium ion homeostasis (GO:0055075)2.16151338
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.15991997
153inner ear receptor cell development (GO:0060119)2.14044395
154protein localization to synapse (GO:0035418)2.13909119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.60882150
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.53168899
3* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89396893
4DROSHA_22980978_ChIP-Seq_HELA_Human2.54489668
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.45101705
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36002315
7WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.34353322
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30793329
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30793329
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27316463
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14502653
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12349444
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11605961
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09744371
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09713665
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.06116802
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.06113981
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04616124
19* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.04601785
20KDM2B_26808549_Chip-Seq_K562_Human2.03315437
21ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02190173
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.95519656
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94295712
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94184197
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90023473
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88126716
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.87155684
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86988890
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84354567
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81258616
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.80831119
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80614572
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79812123
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78484908
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76955869
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74521092
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72805813
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70070008
39KDM2B_26808549_Chip-Seq_DND41_Human1.68306573
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66328288
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.62602859
42VDR_21846776_ChIP-Seq_THP-1_Human1.59380141
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58698681
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58584899
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.55917529
46* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54652419
47REST_21632747_ChIP-Seq_MESCs_Mouse1.52504991
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51096267
49* SMC4_20622854_ChIP-Seq_HELA_Human1.51047946
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49715718
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.49669340
52LXR_22292898_ChIP-Seq_THP-1_Human1.48831906
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48611295
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.47712516
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46682903
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.45981448
57P68_20966046_ChIP-Seq_HELA_Human1.42940930
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.38322573
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.36415151
60GBX2_23144817_ChIP-Seq_PC3_Human1.33749292
61RACK7_27058665_Chip-Seq_MCF-7_Human1.33743112
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31658808
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.30511759
64* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29992730
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.28692226
66AR_19668381_ChIP-Seq_PC3_Human1.28432679
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.25304683
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25037181
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23511389
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23178220
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21791892
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.20334327
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20092239
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.19741355
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19460355
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17459334
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17226801
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.16906744
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16461184
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15773687
81CREB1_26743006_Chip-Seq_LNCaP_Human1.14903128
82ZNF274_21170338_ChIP-Seq_K562_Hela1.14771651
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14414777
84OCT4_19829295_ChIP-Seq_ESCs_Human1.13731477
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11654728
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10644268
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10627055
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10358236
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09732743
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09695150
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08612541
92TCF7_22412390_ChIP-Seq_EML_Mouse1.07992111
93CLOCK_20551151_ChIP-Seq_293T_Human1.07583386
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05604056
95CTCF_27219007_Chip-Seq_Bcells_Human1.04828867
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04464711
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.04433446
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03324778
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.02949809
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02420038
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.02374672
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.02192336
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01581468
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.01512232
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00882230
106MYC_22102868_ChIP-Seq_BL_Human0.98758686
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.97606785
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.97463447
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.96701811
110* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96595835
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.95698361
112AR_21572438_ChIP-Seq_LNCaP_Human0.95172247
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94997106
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94204370
115* TP63_22573176_ChIP-Seq_HFKS_Human0.93414863
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93271671
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92649009
118KLF4_19829295_ChIP-Seq_ESCs_Human0.92309588
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91564271
120TP53_22127205_ChIP-Seq_IMR90_Human0.90787091
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90358662
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90228026
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.89789414
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.89789414
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89638641
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89255399
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89091170
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.88393141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.98474700
2MP0003283_abnormal_digestive_organ3.61674820
3MP0003122_maternal_imprinting3.24839034
4MP0009780_abnormal_chondrocyte_physiolo2.79025328
5MP0000569_abnormal_digit_pigmentation2.63050735
6MP0003879_abnormal_hair_cell2.23297110
7MP0003690_abnormal_glial_cell2.19161245
8MP0002909_abnormal_adrenal_gland2.16688100
9MP0008961_abnormal_basal_metabolism2.16285781
10MP0001348_abnormal_lacrimal_gland2.15765702
11MP0004858_abnormal_nervous_system2.13224069
12MP0003635_abnormal_synaptic_transmissio2.13098969
13MP0002822_catalepsy2.06762039
14MP0005623_abnormal_meninges_morphology2.03068149
15MP0003705_abnormal_hypodermis_morpholog1.87512613
16MP0004270_analgesia1.87352431
17MP0002272_abnormal_nervous_system1.86778110
18MP0002234_abnormal_pharynx_morphology1.79899094
19MP0000537_abnormal_urethra_morphology1.76468890
20MP0002653_abnormal_ependyma_morphology1.75457077
21MP0005409_darkened_coat_color1.73304442
22MP0005058_abnormal_lysosome_morphology1.72293407
23MP0004233_abnormal_muscle_weight1.72140655
24MP0003121_genomic_imprinting1.68727007
25MP0000778_abnormal_nervous_system1.67189419
26MP0010030_abnormal_orbit_morphology1.66397339
27MP0000013_abnormal_adipose_tissue1.64237799
28MP0002063_abnormal_learning/memory/cond1.61624249
29MP0000534_abnormal_ureter_morphology1.56368620
30MP0004272_abnormal_basement_membrane1.54632491
31MP0003123_paternal_imprinting1.53651832
32MP0003787_abnormal_imprinting1.52915190
33MP0001299_abnormal_eye_distance/1.50000146
34MP0000751_myopathy1.49200698
35MP0005076_abnormal_cell_differentiation1.48968459
36MP0000920_abnormal_myelination1.48382929
37MP0008438_abnormal_cutaneous_collagen1.45307133
38MP0003385_abnormal_body_wall1.43624909
39MP0001970_abnormal_pain_threshold1.43424329
40MP0003119_abnormal_digestive_system1.43058359
41MP0000003_abnormal_adipose_tissue1.41360948
42MP0000604_amyloidosis1.38419056
43MP0002249_abnormal_larynx_morphology1.37765411
44MP0001501_abnormal_sleep_pattern1.35615494
45MP0003942_abnormal_urinary_system1.35442515
46MP0000955_abnormal_spinal_cord1.34887710
47MP0003115_abnormal_respiratory_system1.34193923
48MP0000428_abnormal_craniofacial_morphol1.33434338
49MP0004145_abnormal_muscle_electrophysio1.32303629
50MP0002184_abnormal_innervation1.29726072
51MP0004811_abnormal_neuron_physiology1.29084670
52MP0005187_abnormal_penis_morphology1.27578629
53MP0004885_abnormal_endolymph1.24458947
54MP0003172_abnormal_lysosome_physiology1.22972136
55MP0005423_abnormal_somatic_nervous1.22778185
56MP0001849_ear_inflammation1.21422587
57MP0001440_abnormal_grooming_behavior1.18148023
58MP0002066_abnormal_motor_capabilities/c1.18031314
59MP0009745_abnormal_behavioral_response1.17970187
60MP0003633_abnormal_nervous_system1.17831332
61MP0002735_abnormal_chemical_nociception1.16905898
62MP0002064_seizures1.16408647
63MP0001968_abnormal_touch/_nociception1.15711483
64MP0002089_abnormal_postnatal_growth/wei1.14650282
65MP0002067_abnormal_sensory_capabilities1.13529533
66MP0009278_abnormal_bone_marrow1.12914120
67MP0002896_abnormal_bone_mineralization1.12323515
68MP0002572_abnormal_emotion/affect_behav1.11187425
69MP0000733_abnormal_muscle_development1.08386398
70MP0004084_abnormal_cardiac_muscle1.08129234
71MP0002837_dystrophic_cardiac_calcinosis1.07531235
72MP0003935_abnormal_craniofacial_develop1.07161343
73MP0003631_nervous_system_phenotype1.05587295
74MP0002734_abnormal_mechanical_nocicepti1.04581388
75MP0003861_abnormal_nervous_system1.03951621
76MP0006276_abnormal_autonomic_nervous1.03608949
77MP0000678_abnormal_parathyroid_gland1.03464775
78MP0002557_abnormal_social/conspecific_i1.03407484
79MP0005503_abnormal_tendon_morphology1.03333306
80MP0002152_abnormal_brain_morphology1.02582876
81MP0008260_abnormal_autophagy1.02029619
82MP0010234_abnormal_vibrissa_follicle1.01816865
83MP0004130_abnormal_muscle_cell1.00474568
84MP0003279_aneurysm1.00279814
85MP0004510_myositis1.00114244
86MP0005645_abnormal_hypothalamus_physiol0.99770276
87MP0003045_fibrosis0.99320290
88MP0000631_abnormal_neuroendocrine_gland0.99262479
89MP0002882_abnormal_neuron_morphology0.97630972
90MP0002733_abnormal_thermal_nociception0.96733693
91MP0008569_lethality_at_weaning0.95868090
92MP0001944_abnormal_pancreas_morphology0.94660681
93MP0002877_abnormal_melanocyte_morpholog0.94268568
94MP0003632_abnormal_nervous_system0.92926651
95MP0000462_abnormal_digestive_system0.92739811
96MP0000566_synostosis0.92150069
97MP0002932_abnormal_joint_morphology0.89997879
98MP0003329_amyloid_beta_deposits0.89658221
99MP0002116_abnormal_craniofacial_bone0.88134818
100MP0005248_abnormal_Harderian_gland0.88067447
101MP0003091_abnormal_cell_migration0.87567198
102MP0004742_abnormal_vestibular_system0.87561290
103MP0009053_abnormal_anal_canal0.87040903
104MP0003300_gastrointestinal_ulcer0.86421512
105MP0003137_abnormal_impulse_conducting0.86111313
106MP0001177_atelectasis0.85448622
107MP0001958_emphysema0.84959819
108MP0003183_abnormal_peptide_metabolism0.83193074
109MP0009672_abnormal_birth_weight0.81717673
110MP0009384_cardiac_valve_regurgitation0.81625793
111MP0001502_abnormal_circadian_rhythm0.81336321
112MP0004085_abnormal_heartbeat0.80985299
113MP0001486_abnormal_startle_reflex0.79846525
114MP0005257_abnormal_intraocular_pressure0.79396202
115MP0009046_muscle_twitch0.78947362
116MP0005375_adipose_tissue_phenotype0.78846969
117MP0001963_abnormal_hearing_physiology0.78685781
118MP0003880_abnormal_central_pattern0.78667680
119MP0002108_abnormal_muscle_morphology0.78004074
120MP0000767_abnormal_smooth_muscle0.77771132
121MP0001270_distended_abdomen0.77493559
122MP0005167_abnormal_blood-brain_barrier0.76205823
123MP0002925_abnormal_cardiovascular_devel0.75280796
124MP0009703_decreased_birth_body0.75113486
125MP0004924_abnormal_behavior0.74881455
126MP0005386_behavior/neurological_phenoty0.74881455
127MP0004087_abnormal_muscle_fiber0.74786776
128MP0006072_abnormal_retinal_apoptosis0.74574771
129MP0002084_abnormal_developmental_patter0.74394470
130MP0003634_abnormal_glial_cell0.73936478
131MP0000049_abnormal_middle_ear0.73445989
132MP0002081_perinatal_lethality0.73170088
133MP0010386_abnormal_urinary_bladder0.72903449
134MP0008874_decreased_physiological_sensi0.72677522
135MP0005499_abnormal_olfactory_system0.72456660
136MP0005394_taste/olfaction_phenotype0.72456660
137MP0002697_abnormal_eye_size0.72048475
138MP0004133_heterotaxia0.71302381
139MP0002229_neurodegeneration0.70886725
140MP0003938_abnormal_ear_development0.70516453
141MP0002933_joint_inflammation0.69217289
142MP0010368_abnormal_lymphatic_system0.67864445
143MP0001984_abnormal_olfaction0.67390394
144MP0001943_abnormal_respiration0.66532343
145MP0000747_muscle_weakness0.64979493
146MP0002133_abnormal_respiratory_system0.62195941
147MP0005388_respiratory_system_phenotype0.62195941
148MP0003948_abnormal_gas_homeostasis0.62063835
149MP0005275_abnormal_skin_tensile0.59984295
150MP0005535_abnormal_body_temperature0.59885030

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.23300165
2Neurofibrillary tangles (HP:0002185)3.82253264
3Hyperacusis (HP:0010780)3.41714870
4Annular pancreas (HP:0001734)3.26470589
5Renal duplication (HP:0000075)3.15449698
6Cerebral aneurysm (HP:0004944)3.14546936
7Shallow orbits (HP:0000586)3.13936489
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.95644282
9Insomnia (HP:0100785)2.94578872
10Elfin facies (HP:0004428)2.93908420
11Neoplasm of the heart (HP:0100544)2.90098835
12Macroorchidism (HP:0000053)2.84702491
13Abnormality of binocular vision (HP:0011514)2.84640525
14Diplopia (HP:0000651)2.84640525
15Short 4th metacarpal (HP:0010044)2.82865790
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82865790
17Focal motor seizures (HP:0011153)2.80201457
18Sleep apnea (HP:0010535)2.77731443
19Renovascular hypertension (HP:0100817)2.70138267
20Bladder diverticulum (HP:0000015)2.62054913
21Bowel diverticulosis (HP:0005222)2.57890525
22Epileptic encephalopathy (HP:0200134)2.56840402
23Broad metatarsal (HP:0001783)2.53334019
24Pointed chin (HP:0000307)2.53173979
25Broad face (HP:0000283)2.52758681
26Neuronal loss in central nervous system (HP:0002529)2.52286750
27Spinal canal stenosis (HP:0003416)2.45966938
28Overriding aorta (HP:0002623)2.45646508
29Abnormal eating behavior (HP:0100738)2.42207916
30Protrusio acetabuli (HP:0003179)2.41427809
31Spastic gait (HP:0002064)2.36372612
32Peripheral hypomyelination (HP:0007182)2.33476695
33Flat cornea (HP:0007720)2.33042254
34Abnormality of the 4th metacarpal (HP:0010012)2.32805000
35Visual hallucinations (HP:0002367)2.31359964
36Febrile seizures (HP:0002373)2.31222480
37Turricephaly (HP:0000262)2.30892617
38Lymphangioma (HP:0100764)2.22692305
39Cervical subluxation (HP:0003308)2.20740996
40Enlarged penis (HP:0000040)2.18833257
41Truncal ataxia (HP:0002078)2.18443519
42Hepatoblastoma (HP:0002884)2.15229712
43Abnormality of the lower motor neuron (HP:0002366)2.15140851
44Supranuclear gaze palsy (HP:0000605)2.15084209
45Genetic anticipation (HP:0003743)2.12838348
46Mutism (HP:0002300)2.10262854
47Distal upper limb amyotrophy (HP:0007149)2.09053129
48Upper limb amyotrophy (HP:0009129)2.09053129
49Buphthalmos (HP:0000557)2.06576932
50Congenital glaucoma (HP:0001087)2.01534808
51Hypoventilation (HP:0002791)2.01314715
52Long toe (HP:0010511)2.01059348
53Ankyloglossia (HP:0010296)2.00890094
54Postural instability (HP:0002172)1.97914081
55Obsessive-compulsive behavior (HP:0000722)1.97293091
56Apathy (HP:0000741)1.96955206
57Focal seizures (HP:0007359)1.96245244
58Agitation (HP:0000713)1.95830370
59Stereotypic behavior (HP:0000733)1.95386176
60Urinary bladder sphincter dysfunction (HP:0002839)1.94440379
61Dysmetria (HP:0001310)1.93008306
62Impaired smooth pursuit (HP:0007772)1.91882128
63Hand muscle atrophy (HP:0009130)1.91599875
64Aplasia involving bones of the upper limbs (HP:0009823)1.90816267
65Aplasia of the phalanges of the hand (HP:0009802)1.90816267
66Aplasia involving bones of the extremities (HP:0009825)1.90816267
67Dysostosis multiplex (HP:0000943)1.90657101
68Ankle contracture (HP:0006466)1.90385554
69Lower limb asymmetry (HP:0100559)1.89880410
70Aneurysm (HP:0002617)1.89546368
71Bronchomalacia (HP:0002780)1.88773100
72Atonic seizures (HP:0010819)1.88234717
73Rapidly progressive (HP:0003678)1.88100380
74Depression (HP:0000716)1.87967220
75Myokymia (HP:0002411)1.86326099
76Ankle clonus (HP:0011448)1.83718026
77Mitral regurgitation (HP:0001653)1.83711196
78Action tremor (HP:0002345)1.82527491
79Deviation of the hallux (HP:0010051)1.82277975
80Disproportionate tall stature (HP:0001519)1.81689121
81Mitral valve prolapse (HP:0001634)1.80448216
82Trigonocephaly (HP:0000243)1.80059333
83Abnormality of the astrocytes (HP:0100707)1.79797083
84Astrocytoma (HP:0009592)1.79797083
85Stridor (HP:0010307)1.79304717
86Nuclear cataract (HP:0100018)1.79281981
87Diminished motivation (HP:0000745)1.79099340
88Urinary glycosaminoglycan excretion (HP:0003541)1.77799779
89Mucopolysacchariduria (HP:0008155)1.77799779
90Dilatation of the ascending aorta (HP:0005111)1.77396197
91Hemiplegia (HP:0002301)1.77222002
92Abnormality of oral frenula (HP:0000190)1.76735840
93Hallux valgus (HP:0001822)1.76664817
94Mildly elevated creatine phosphokinase (HP:0008180)1.76025622
95Distal lower limb amyotrophy (HP:0008944)1.75554760
96Striae distensae (HP:0001065)1.74610500
97Broad thumb (HP:0011304)1.74402357
98Focal dystonia (HP:0004373)1.74114744
99Narrow palate (HP:0000189)1.74103446
100Hypercortisolism (HP:0001578)1.73772728
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73140167
102Difficulty running (HP:0009046)1.72540281
103Abnormality of polysaccharide metabolism (HP:0011012)1.71356393
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71356393
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71356393
106Abnormality of the diencephalon (HP:0010662)1.70787499
107Onion bulb formation (HP:0003383)1.70079357
108Intention tremor (HP:0002080)1.68974182
109Craniofacial dystonia (HP:0012179)1.67936969
110Hammertoe (HP:0001765)1.66758229
111Abnormality of the fingertips (HP:0001211)1.66568937
112Abnormality of ocular smooth pursuit (HP:0000617)1.66179589
113Biconcave vertebral bodies (HP:0004586)1.65114305
114Lower limb muscle weakness (HP:0007340)1.64478127
115Vitreoretinal degeneration (HP:0000655)1.64163549
116Sacral dimple (HP:0000960)1.63886520
117Aortic aneurysm (HP:0004942)1.63668248
118Scapular winging (HP:0003691)1.63611872
119Akinesia (HP:0002304)1.63589671
120Thin bony cortex (HP:0002753)1.63126722
121Abnormality of the aortic arch (HP:0012303)1.62523534
122Difficulty climbing stairs (HP:0003551)1.61956671
123Premature rupture of membranes (HP:0001788)1.60784722
124Arnold-Chiari malformation (HP:0002308)1.60515743
125Increased nuchal translucency (HP:0010880)1.60479208
126Thin ribs (HP:0000883)1.59378687
127Megalocornea (HP:0000485)1.58761776
128Megalencephaly (HP:0001355)1.58497255
129Metaphyseal cupping (HP:0003021)1.58115249
130Abnormality of calcium-phosphate metabolism (HP:0100530)1.56293545
131Precocious puberty (HP:0000826)1.55724637
132Open mouth (HP:0000194)1.55401081
133Increased variability in muscle fiber diameter (HP:0003557)1.54944247
134Ventricular fibrillation (HP:0001663)1.53507021
135Papilledema (HP:0001085)1.51337101
136Heterotopia (HP:0002282)1.50793208
137Lower limb amyotrophy (HP:0007210)1.50591733
138Cerebral inclusion bodies (HP:0100314)1.49160595
139Broad finger (HP:0001500)1.48633010
140Broad phalanges of the hand (HP:0009768)1.48554633
141Hemiparesis (HP:0001269)1.48155323
142Exostoses (HP:0100777)1.46997438
143Mask-like facies (HP:0000298)1.46784071
144Genu recurvatum (HP:0002816)1.46388026
145Long palpebral fissure (HP:0000637)1.46228187
146Arterial tortuosity (HP:0005116)1.46223116
147Cutaneous finger syndactyly (HP:0010554)1.46199143
148Broad long bones (HP:0005622)1.45761911
149Atrophic scars (HP:0001075)1.45593422
150Vertebral arch anomaly (HP:0008438)1.45183297
151Overgrowth (HP:0001548)1.44762142
152Ependymoma (HP:0002888)1.43964585
153Progressive cerebellar ataxia (HP:0002073)1.43423699
154Broad phalanx (HP:0006009)1.41616843
155Prolonged QT interval (HP:0001657)1.40708831
156Narrow nasal bridge (HP:0000446)1.38517071
157Torticollis (HP:0000473)1.38494813
158Type 1 muscle fiber predominance (HP:0003803)1.38471807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.17110648
2NTRK32.56864165
3PRPF4B2.48427185
4PRKD32.45530746
5PDGFRA2.45388510
6PKN22.43352191
7RIPK12.39008740
8MAP3K92.24091419
9MARK12.17529326
10PAK61.92823923
11MAP3K101.91479676
12CAMK1G1.79667686
13TYRO31.77070584
14ICK1.76612056
15CDK121.75657449
16KSR11.73545887
17SIK11.65831593
18SIK21.64969552
19NTRK11.64878169
20KSR21.62878542
21PTK61.60785550
22NTRK21.60548022
23DDR21.56296822
24MINK11.50889486
25TNK21.49926166
26BRD41.48788519
27EPHB21.48652299
28MAP3K41.48487348
29LATS21.42387444
30UHMK11.42165407
31MAP3K131.40682031
32DAPK21.38850933
33TTN1.37552520
34EPHA41.36701163
35CAMKK11.35090730
36EEF2K1.33967681
37RET1.33093909
38PAK31.31650540
39CDC42BPA1.31182187
40PTK21.30032301
41FGFR21.27149656
42CAMK1D1.22383414
43MAP3K21.21189843
44SMG11.21179382
45INSRR1.20957593
46STK381.16816517
47MTOR1.15383799
48MAPK121.15326716
49DMPK1.14444926
50PRKCH1.13638114
51LMTK21.09793506
52LATS11.07793192
53MAP3K61.06868065
54RIPK41.06569508
55ALK1.05870205
56MARK21.04852655
57FER1.04793217
58WNK31.04353756
59FES1.03029005
60MAP3K111.02650184
61FGFR11.00561899
62PASK0.99251315
63ERBB20.98828809
64ERN10.94565452
65PDGFRB0.93010166
66PHKG20.91895208
67PHKG10.91895208
68SCYL20.90602463
69CDK50.88089126
70WNK10.85644571
71MAP3K70.83749387
72SGK20.83302223
73HIPK20.82782324
74PAK20.81795981
75RPS6KA20.81204879
76PDPK10.78211866
77TAOK10.78061572
78MAP2K30.74967452
79ARAF0.74909905
80CDK190.71119983
81MAPK150.70631599
82PDK10.69860171
83EPHB10.69038068
84MAP2K40.66671208
85EPHA30.66160669
86MAP2K60.63896172
87PRKD20.63702618
88BMX0.62262105
89MAP4K10.61864616
90RPS6KC10.60487634
91RPS6KL10.60487634
92DYRK1B0.59872538
93SIK30.59732002
94MAPK70.59404511
95PRKD10.59063050
96WNK40.58965876
97FGFR30.57792758
98CDK11A0.56401176
99NEK10.56245546
100PAK40.56159076
101ROCK10.55776525
102FGFR40.54945021
103SGK30.54675515
104MAP3K10.54401321
105ERBB30.53184999
106PNCK0.51384947
107ZAP700.49992995
108CDK180.48545225
109TESK10.48332747
110SGK10.48309383
111CDK150.47372265
112MAPK100.47144179
113SRC0.47113842
114PRKCZ0.46598537
115CAMK10.46363390
116PRKCG0.45908791
117RPS6KA60.44695268
118DYRK1A0.44611066
119STK110.44170290
120CDK140.43963728
121GRK50.43580088
122RPS6KA30.43571575
123FYN0.43360216
124CASK0.43012388
125CAMK40.42938149
126CSNK1A1L0.41079621
127SGK2230.40795605
128SGK4940.40795605
129CSNK1G20.40033655
130MAPK80.39889176

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049111.98821770
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97393852
3Type II diabetes mellitus_Homo sapiens_hsa049301.80936304
4Circadian entrainment_Homo sapiens_hsa047131.77658081
5Synaptic vesicle cycle_Homo sapiens_hsa047211.70923289
6Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62822369
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59747431
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57684970
9GABAergic synapse_Homo sapiens_hsa047271.57591883
10Long-term potentiation_Homo sapiens_hsa047201.54154038
11Other glycan degradation_Homo sapiens_hsa005111.49031100
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46458834
13Dopaminergic synapse_Homo sapiens_hsa047281.45614613
14Cocaine addiction_Homo sapiens_hsa050301.44958669
15Axon guidance_Homo sapiens_hsa043601.42825478
16Dilated cardiomyopathy_Homo sapiens_hsa054141.41881641
17Amphetamine addiction_Homo sapiens_hsa050311.41534387
18Cholinergic synapse_Homo sapiens_hsa047251.39739668
19Estrogen signaling pathway_Homo sapiens_hsa049151.39022567
20Glioma_Homo sapiens_hsa052141.38394708
21Basal cell carcinoma_Homo sapiens_hsa052171.36749378
22Olfactory transduction_Homo sapiens_hsa047401.36523644
23Glutamatergic synapse_Homo sapiens_hsa047241.35898553
24Morphine addiction_Homo sapiens_hsa050321.35006434
25Gastric acid secretion_Homo sapiens_hsa049711.33941993
26Nicotine addiction_Homo sapiens_hsa050331.31198199
27Gap junction_Homo sapiens_hsa045401.30268468
28Melanogenesis_Homo sapiens_hsa049161.30153115
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30054904
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27805140
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26819803
32Hedgehog signaling pathway_Homo sapiens_hsa043401.26039249
33mTOR signaling pathway_Homo sapiens_hsa041501.24880399
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.22571577
35Endometrial cancer_Homo sapiens_hsa052131.21689726
36Oxytocin signaling pathway_Homo sapiens_hsa049211.21413902
37GnRH signaling pathway_Homo sapiens_hsa049121.21002667
38Salivary secretion_Homo sapiens_hsa049701.20232049
39Renin secretion_Homo sapiens_hsa049241.18996090
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18123320
41Hippo signaling pathway_Homo sapiens_hsa043901.14510505
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.14490304
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.14434467
44Focal adhesion_Homo sapiens_hsa045101.12547213
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10088623
46Chronic myeloid leukemia_Homo sapiens_hsa052201.09656058
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08672735
48ErbB signaling pathway_Homo sapiens_hsa040121.08095641
49Proteoglycans in cancer_Homo sapiens_hsa052051.07977082
50Lysine degradation_Homo sapiens_hsa003101.07925187
51Notch signaling pathway_Homo sapiens_hsa043301.06114786
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05190041
53Dorso-ventral axis formation_Homo sapiens_hsa043201.04852226
54cAMP signaling pathway_Homo sapiens_hsa040241.04238686
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03871837
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03851182
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02507462
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00951870
59Inositol phosphate metabolism_Homo sapiens_hsa005620.99206296
60Wnt signaling pathway_Homo sapiens_hsa043100.97969226
61Adherens junction_Homo sapiens_hsa045200.97338262
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96619977
63Taste transduction_Homo sapiens_hsa047420.96401525
64Long-term depression_Homo sapiens_hsa047300.96253999
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96071943
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95700163
67Glucagon signaling pathway_Homo sapiens_hsa049220.93531715
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.93410621
69Insulin signaling pathway_Homo sapiens_hsa049100.92839107
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.92758573
71Colorectal cancer_Homo sapiens_hsa052100.91581476
72ECM-receptor interaction_Homo sapiens_hsa045120.91377371
73Renal cell carcinoma_Homo sapiens_hsa052110.91080955
74Non-small cell lung cancer_Homo sapiens_hsa052230.90825946
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90240245
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90048526
77Thyroid hormone synthesis_Homo sapiens_hsa049180.88952791
78Insulin resistance_Homo sapiens_hsa049310.85078653
79Bladder cancer_Homo sapiens_hsa052190.83764624
80Ras signaling pathway_Homo sapiens_hsa040140.83283383
81VEGF signaling pathway_Homo sapiens_hsa043700.83005245
82Rap1 signaling pathway_Homo sapiens_hsa040150.82598964
83Calcium signaling pathway_Homo sapiens_hsa040200.82538003
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82478976
85Acute myeloid leukemia_Homo sapiens_hsa052210.80842102
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.78227510
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77699239
88Choline metabolism in cancer_Homo sapiens_hsa052310.77018436
89Serotonergic synapse_Homo sapiens_hsa047260.74852166
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73939836
91Tight junction_Homo sapiens_hsa045300.72952048
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72936613
93Bile secretion_Homo sapiens_hsa049760.72797874
94B cell receptor signaling pathway_Homo sapiens_hsa046620.71454375
95MicroRNAs in cancer_Homo sapiens_hsa052060.70740068
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.70295755
97MAPK signaling pathway_Homo sapiens_hsa040100.69535408
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68721574
99Protein digestion and absorption_Homo sapiens_hsa049740.68531435
100AMPK signaling pathway_Homo sapiens_hsa041520.68166132
101Amoebiasis_Homo sapiens_hsa051460.68101665
102Pancreatic secretion_Homo sapiens_hsa049720.68022421
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67588988
104Nitrogen metabolism_Homo sapiens_hsa009100.66441754
105Osteoclast differentiation_Homo sapiens_hsa043800.65004692
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64695520
107Endocytosis_Homo sapiens_hsa041440.63555734
108Prolactin signaling pathway_Homo sapiens_hsa049170.63366436
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61332857
110Vibrio cholerae infection_Homo sapiens_hsa051100.61313796
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61304076
112Oocyte meiosis_Homo sapiens_hsa041140.61090680
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60418567
114Pancreatic cancer_Homo sapiens_hsa052120.60133662
115Lysosome_Homo sapiens_hsa041420.58028852
116Prion diseases_Homo sapiens_hsa050200.57556487
117Chemokine signaling pathway_Homo sapiens_hsa040620.54890857
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.53359370
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.53277429
120Platelet activation_Homo sapiens_hsa046110.52432363

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