NIPSNAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.70987908
2L-phenylalanine catabolic process (GO:0006559)7.70987908
3L-phenylalanine metabolic process (GO:0006558)7.42699918
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.42699918
5aromatic amino acid family catabolic process (GO:0009074)6.92713514
6indole-containing compound catabolic process (GO:0042436)6.23699977
7indolalkylamine catabolic process (GO:0046218)6.23699977
8tryptophan catabolic process (GO:0006569)6.23699977
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11891291
10kynurenine metabolic process (GO:0070189)6.07908346
11glyoxylate metabolic process (GO:0046487)6.04452973
12tryptophan metabolic process (GO:0006568)5.87200808
13bile acid biosynthetic process (GO:0006699)5.86886137
14urea cycle (GO:0000050)5.60719394
15urea metabolic process (GO:0019627)5.60719394
16high-density lipoprotein particle remodeling (GO:0034375)5.48989285
17negative regulation of fibrinolysis (GO:0051918)5.48121200
18serine family amino acid catabolic process (GO:0009071)5.43259774
19cysteine metabolic process (GO:0006534)5.37446528
20regulation of fibrinolysis (GO:0051917)5.31852598
21sulfur amino acid catabolic process (GO:0000098)5.20937655
22nitrogen cycle metabolic process (GO:0071941)5.17464265
23aromatic amino acid family metabolic process (GO:0009072)5.13713860
24alpha-linolenic acid metabolic process (GO:0036109)5.12976557
25bile acid metabolic process (GO:0008206)4.99496791
26regulation of protein activation cascade (GO:2000257)4.95656610
27tyrosine metabolic process (GO:0006570)4.95438052
28cellular ketone body metabolic process (GO:0046950)4.95190082
29lysine metabolic process (GO:0006553)4.86385923
30lysine catabolic process (GO:0006554)4.86385923
31protein carboxylation (GO:0018214)4.86078980
32peptidyl-glutamic acid carboxylation (GO:0017187)4.86078980
33regulation of cholesterol esterification (GO:0010872)4.83489657
34complement activation, alternative pathway (GO:0006957)4.81026285
35alpha-amino acid catabolic process (GO:1901606)4.80879701
36L-serine metabolic process (GO:0006563)4.69896681
37reverse cholesterol transport (GO:0043691)4.69141927
38glycine metabolic process (GO:0006544)4.65639521
39homocysteine metabolic process (GO:0050667)4.65353543
40coenzyme catabolic process (GO:0009109)4.61640056
41protein-lipid complex remodeling (GO:0034368)4.60583649
42macromolecular complex remodeling (GO:0034367)4.60583649
43plasma lipoprotein particle remodeling (GO:0034369)4.60583649
44regulation of complement activation (GO:0030449)4.57851165
45negative regulation of cholesterol transport (GO:0032375)4.56194120
46negative regulation of sterol transport (GO:0032372)4.56194120
47imidazole-containing compound metabolic process (GO:0052803)4.55275212
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55174611
49indolalkylamine metabolic process (GO:0006586)4.54123994
50glutamate metabolic process (GO:0006536)4.49342063
51amino-acid betaine metabolic process (GO:0006577)4.45570620
52triglyceride homeostasis (GO:0070328)4.45197915
53acylglycerol homeostasis (GO:0055090)4.45197915
54cellular amino acid catabolic process (GO:0009063)4.44154925
55aldehyde catabolic process (GO:0046185)4.43958894
56serine family amino acid metabolic process (GO:0009069)4.42948711
57regulation of triglyceride catabolic process (GO:0010896)4.39126323
58phospholipid efflux (GO:0033700)4.32818642
59drug catabolic process (GO:0042737)4.32475821
60bile acid and bile salt transport (GO:0015721)4.30521897
61cellular biogenic amine catabolic process (GO:0042402)4.29727984
62amine catabolic process (GO:0009310)4.29727984
63ketone body metabolic process (GO:1902224)4.28798840
64serine family amino acid biosynthetic process (GO:0009070)4.20345373
65benzene-containing compound metabolic process (GO:0042537)4.18491103
66arginine metabolic process (GO:0006525)4.15527715
67cellular modified amino acid catabolic process (GO:0042219)4.14662232
68dicarboxylic acid biosynthetic process (GO:0043650)4.12240628
69cholesterol efflux (GO:0033344)4.04567363
70cellular glucuronidation (GO:0052695)4.03165099
71ethanol oxidation (GO:0006069)4.02613766
72plasma lipoprotein particle clearance (GO:0034381)3.89611280
73blood coagulation, intrinsic pathway (GO:0007597)3.80591440
74low-density lipoprotein particle remodeling (GO:0034374)3.80177390
75organic acid catabolic process (GO:0016054)3.79870418
76carboxylic acid catabolic process (GO:0046395)3.79870418
77cofactor catabolic process (GO:0051187)3.78907612
78short-chain fatty acid metabolic process (GO:0046459)3.78895567
79exogenous drug catabolic process (GO:0042738)3.76935434
80pyrimidine nucleobase catabolic process (GO:0006208)3.74121531
81acetyl-CoA metabolic process (GO:0006084)3.73277945
82NAD biosynthetic process (GO:0009435)3.69544484
83aspartate family amino acid catabolic process (GO:0009068)3.67723770
84glucuronate metabolic process (GO:0019585)3.67610781
85uronic acid metabolic process (GO:0006063)3.67610781
86urate metabolic process (GO:0046415)3.65701431
87plasma lipoprotein particle assembly (GO:0034377)3.63320521
88fibrinolysis (GO:0042730)3.63067599
89drug transmembrane transport (GO:0006855)3.61223929
90peptidyl-arginine omega-N-methylation (GO:0035247)3.56974015
91nicotinamide nucleotide biosynthetic process (GO:0019359)3.55013420
92pyridine nucleotide biosynthetic process (GO:0019363)3.55013420
93regulation of bile acid biosynthetic process (GO:0070857)3.54804205
94cytolysis (GO:0019835)3.53898215
95flavonoid metabolic process (GO:0009812)3.51677098
96drug metabolic process (GO:0017144)3.48737662
97complement activation, classical pathway (GO:0006958)3.48516298
98establishment of integrated proviral latency (GO:0075713)3.46733303
992-oxoglutarate metabolic process (GO:0006103)3.46724675
100indole-containing compound metabolic process (GO:0042430)3.46116090
101paraxial mesoderm development (GO:0048339)3.45477874
102negative regulation of lipase activity (GO:0060192)3.43960674
103cholesterol homeostasis (GO:0042632)3.43107427
104nucleobase catabolic process (GO:0046113)3.42906170
105protein activation cascade (GO:0072376)3.40978998
106histone arginine methylation (GO:0034969)3.35072787
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.24489989
108peptidyl-arginine methylation (GO:0018216)3.08337282
109peptidyl-arginine N-methylation (GO:0035246)3.08337282
110regulation of posttranscriptional gene silencing (GO:0060147)3.04065415
111regulation of gene silencing by miRNA (GO:0060964)3.04065415
112regulation of gene silencing by RNA (GO:0060966)3.04065415
113cholesterol biosynthetic process (GO:0006695)2.97416764
114ribosomal small subunit assembly (GO:0000028)2.92205966
115protein-DNA complex disassembly (GO:0032986)2.84076393
116nucleosome disassembly (GO:0006337)2.84076393
117heterochromatin organization (GO:0070828)2.83045027
118pre-miRNA processing (GO:0031054)2.79502273
119DNA damage response, detection of DNA damage (GO:0042769)2.75290749
120establishment of viral latency (GO:0019043)2.72329782
121establishment of mitochondrion localization (GO:0051654)2.72313121
122proline metabolic process (GO:0006560)2.72178524
123convergent extension (GO:0060026)2.68829834
124cell migration in hindbrain (GO:0021535)2.61965992
125viral transcription (GO:0019083)2.61253381
126sterol biosynthetic process (GO:0016126)2.57858643
127translational termination (GO:0006415)2.54863647
128biotin metabolic process (GO:0006768)2.53142515
129proline biosynthetic process (GO:0006561)2.52717015
130layer formation in cerebral cortex (GO:0021819)2.46256789
131regulation of translational fidelity (GO:0006450)2.38147582
132neurotransmitter-gated ion channel clustering (GO:0072578)2.37708316
133nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.36841378
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.36811254
135axon extension involved in axon guidance (GO:0048846)2.36811254
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31734995
137protein localization to synapse (GO:0035418)2.30663474
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.30295940
139DNA unwinding involved in DNA replication (GO:0006268)2.29593287
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.29332976
141ephrin receptor signaling pathway (GO:0048013)2.29286609
142presynaptic membrane assembly (GO:0097105)2.28857167
143translational elongation (GO:0006414)2.28489190
144mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.28235671
145cotranslational protein targeting to membrane (GO:0006613)2.28085656
146establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.23753160
147mitochondrion transport along microtubule (GO:0047497)2.23753160
148positive regulation of mitochondrial fission (GO:0090141)2.23658987
149axonal fasciculation (GO:0007413)2.21517283
150protein retention in ER lumen (GO:0006621)2.20324820
151protein targeting to ER (GO:0045047)2.19882600
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.19702645
153ATP-dependent chromatin remodeling (GO:0043044)2.18349810
154protein complex disassembly (GO:0043241)2.18185955
155regulation of cell fate specification (GO:0042659)2.18047104
156DNA ligation (GO:0006266)2.15083283
157olfactory bulb development (GO:0021772)2.13798039
158calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.12708229
159short-term memory (GO:0007614)2.12666437
160establishment of protein localization to endoplasmic reticulum (GO:0072599)2.11755673
1614-hydroxyproline metabolic process (GO:0019471)2.11211881
162macromolecular complex disassembly (GO:0032984)2.10654047
163nonmotile primary cilium assembly (GO:0035058)2.10104774
164postsynaptic membrane organization (GO:0001941)2.09920297
165neuron cell-cell adhesion (GO:0007158)2.09296212
166body morphogenesis (GO:0010171)2.08908845
167negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.08572271
168neuronal stem cell maintenance (GO:0097150)2.08264268
169cellular protein complex disassembly (GO:0043624)2.06267843
170viral life cycle (GO:0019058)2.06151701
171presynaptic membrane organization (GO:0097090)2.04925820
172protein localization to endoplasmic reticulum (GO:0070972)2.04650901
173formation of translation preinitiation complex (GO:0001731)2.03965962
174lung-associated mesenchyme development (GO:0060484)2.03130178
175ectodermal placode formation (GO:0060788)2.03080116
176translational initiation (GO:0006413)2.03052905
177spinal cord association neuron differentiation (GO:0021527)2.01864952
178coenzyme A metabolic process (GO:0015936)2.01624913
179gluconeogenesis (GO:0006094)2.01253234
180DNA strand renaturation (GO:0000733)2.00156931
181glycolytic process (GO:0006096)1.99200554
182negative regulation of microtubule polymerization (GO:0031115)1.99093168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.99880435
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77576098
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.71651896
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.91178177
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17626027
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13850548
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23940169
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.22318798
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66244376
10* MYC_18555785_ChIP-Seq_MESCs_Mouse3.13281466
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79797134
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59075844
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52201585
14E2F7_22180533_ChIP-Seq_HELA_Human2.50734868
15XRN2_22483619_ChIP-Seq_HELA_Human2.20343998
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19159710
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18339983
18* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13217215
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08575931
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07971087
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06141741
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03097886
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00167237
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6364081
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97900905
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93923975
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.93678262
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93498895
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85856442
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82940634
31SOX2_16153702_ChIP-ChIP_HESCs_Human1.80041936
32HTT_18923047_ChIP-ChIP_STHdh_Human1.79811376
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78086641
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73309719
35* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72471237
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72364019
37EZH2_22144423_ChIP-Seq_EOC_Human1.70525402
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69668203
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.68552338
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67749993
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67369781
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.66866164
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66816531
44TTF2_22483619_ChIP-Seq_HELA_Human1.63940043
45TAF15_26573619_Chip-Seq_HEK293_Human1.63684059
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.60297141
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.59126661
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56488132
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55792467
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53326276
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53289395
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52646630
53GABP_19822575_ChIP-Seq_HepG2_Human1.51160041
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.49953572
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49745255
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.48502263
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48238864
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46816693
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46346328
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43468640
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43344609
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42139583
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41813558
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40034369
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.39874968
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.39612569
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34878362
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33973713
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32269320
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29336840
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25907593
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23943170
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22440255
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20906923
75* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18760516
76IGF1R_20145208_ChIP-Seq_DFB_Human1.18440125
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17052579
78AR_21909140_ChIP-Seq_LNCAP_Human1.14400081
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10865020
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.08664460
81DCP1A_22483619_ChIP-Seq_HELA_Human1.06607340
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04918578
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.02484942
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02181153
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01085039
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01085039
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01085039
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01021162
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99587964
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.99050157
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98896180
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.98477223
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94798742
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94502394
95SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94364677
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.93550218
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.93305489
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91857621
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91827869
100KDM5A_27292631_Chip-Seq_BREAST_Human0.91631169
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91349683
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91170815
103POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91137384
104FOXP3_21729870_ChIP-Seq_TREG_Human0.90680145
105GBX2_23144817_ChIP-Seq_PC3_Human0.89490877
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88768908
107* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85412866
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84342048
109* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81740684
110REST_18959480_ChIP-ChIP_MESCs_Mouse0.81352837
111* CLOCK_20551151_ChIP-Seq_293T_Human0.79884219
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.75212351
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75131133
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72597859
115REST_21632747_ChIP-Seq_MESCs_Mouse0.71285049
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70146725
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69270266
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.68698682
119ZNF263_19887448_ChIP-Seq_K562_Human0.68693392
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67091819
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66953024
122* IRF1_19129219_ChIP-ChIP_H3396_Human0.66782955
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65734640
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63717688
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.61885302
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.60827908
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60034868
128MYC_19915707_ChIP-ChIP_AK7_Human0.57793751
129NCOR_22424771_ChIP-Seq_293T_Human0.57363438
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56844400
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.55952961
132* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.55472785
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.55164841
134BCAT_22108803_ChIP-Seq_LS180_Human0.53939955
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.53727751
136AR_20517297_ChIP-Seq_VCAP_Human0.53677249
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52613850
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52051033
139GATA1_22025678_ChIP-Seq_K562_Human0.52007115
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.51722868
141NANOG_16518401_ChIP-PET_MESCs_Mouse0.50455016
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.50181016
143REST_19997604_ChIP-ChIP_NEURONS_Mouse0.49698398
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.49324743
145NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.49123297
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.48055558
147CTCF_27219007_Chip-Seq_Bcells_Human0.46929699
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.46836784
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.46157556
150P300_19829295_ChIP-Seq_ESCs_Human0.46011775
151TAF2_19829295_ChIP-Seq_ESCs_Human0.45698493
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.45695762
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.45312138
154PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.45310149
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.45192913
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.45129352
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.44311302
158STAT1_17558387_ChIP-Seq_HELA_Human0.43308831
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.42659894
160KLF5_20875108_ChIP-Seq_MESCs_Mouse0.42185855
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41933734
162CBP_21632823_ChIP-Seq_H3396_Human0.41924476
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.41305996
164* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.40270169
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.39833171
166POU5F1_16518401_ChIP-PET_MESCs_Mouse0.39356045
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.39354103
168* SOX2_21211035_ChIP-Seq_LN229_Human0.39281663
169MYC_18940864_ChIP-ChIP_HL60_Human0.38681314
170BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.38672356
171SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.38653060
172CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.38479562
173ERG_20517297_ChIP-Seq_VCAP_Human0.38023421
174SPI1_26923725_Chip-Seq_HPCs_Mouse0.38020421
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.37428500
176VDR_22108803_ChIP-Seq_LS180_Human0.36368272
177* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36048441
178* CEBPB_22108803_ChIP-Seq_LS180_Human0.35764717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.34873584
2MP0005360_urolithiasis7.63239706
3MP0005085_abnormal_gallbladder_physiolo6.38613055
4MP0005365_abnormal_bile_salt6.02758077
5MP0008875_abnormal_xenobiotic_pharmacok5.12085585
6MP0003806_abnormal_nucleotide_metabolis4.29676281
7MP0003122_maternal_imprinting3.99681750
8MP0003252_abnormal_bile_duct3.50010027
9MP0010329_abnormal_lipoprotein_level3.41353017
10MP0006292_abnormal_olfactory_placode3.05734819
11MP0005083_abnormal_biliary_tract2.96375565
12MP0005332_abnormal_amino_acid2.91191901
13MP0003195_calcinosis2.84090253
14MP0000566_synostosis2.75975729
15MP0009840_abnormal_foam_cell2.55908875
16MP0010030_abnormal_orbit_morphology2.54674703
17MP0001666_abnormal_nutrient_absorption2.34711669
18MP0003121_genomic_imprinting2.34160713
19MP0004019_abnormal_vitamin_homeostasis2.30051550
20MP0005394_taste/olfaction_phenotype2.27715880
21MP0005499_abnormal_olfactory_system2.27715880
22MP0001293_anophthalmia2.15951804
23MP0003123_paternal_imprinting2.15806287
24MP0000778_abnormal_nervous_system2.03757508
25MP0008789_abnormal_olfactory_epithelium2.00235108
26MP0002653_abnormal_ependyma_morphology1.99734179
27MP0003868_abnormal_feces_composition1.94931794
28MP0003890_abnormal_embryonic-extraembry1.89282202
29MP0002118_abnormal_lipid_homeostasis1.88992755
30MP0000609_abnormal_liver_physiology1.87536382
31MP0002138_abnormal_hepatobiliary_system1.83810277
32MP0001764_abnormal_homeostasis1.81897604
33MP0009697_abnormal_copulation1.78974463
34MP0003191_abnormal_cellular_cholesterol1.77415063
35MP0002697_abnormal_eye_size1.75044684
36MP0002938_white_spotting1.73323603
37MP0004133_heterotaxia1.69144218
38MP0003693_abnormal_embryo_hatching1.68643339
39MP0000049_abnormal_middle_ear1.68407954
40MP0005319_abnormal_enzyme/_coenzyme1.67760564
41MP0002233_abnormal_nose_morphology1.65344673
42MP0003937_abnormal_limbs/digits/tail_de1.64388444
43MP0003787_abnormal_imprinting1.62976887
44MP0008932_abnormal_embryonic_tissue1.56204299
45MP0000537_abnormal_urethra_morphology1.53556696
46MP0002822_catalepsy1.53129519
47MP0005584_abnormal_enzyme/coenzyme_acti1.51516995
48MP0003567_abnormal_fetal_cardiomyocyte1.49832405
49MP0003861_abnormal_nervous_system1.46679371
50MP0003938_abnormal_ear_development1.45315229
51MP0003942_abnormal_urinary_system1.44216420
52MP0003119_abnormal_digestive_system1.42289172
53MP0001286_abnormal_eye_development1.40888761
54MP0004859_abnormal_synaptic_plasticity1.33695016
55MP0002876_abnormal_thyroid_physiology1.31998395
56MP0000955_abnormal_spinal_cord1.28904115
57MP0005377_hearing/vestibular/ear_phenot1.26664101
58MP0003878_abnormal_ear_physiology1.26664101
59MP0003011_delayed_dark_adaptation1.26291127
60MP0003315_abnormal_perineum_morphology1.24307939
61MP0002751_abnormal_autonomic_nervous1.23950983
62MP0003136_yellow_coat_color1.22551101
63MP0002184_abnormal_innervation1.22449948
64MP0002092_abnormal_eye_morphology1.20650562
65MP0004957_abnormal_blastocyst_morpholog1.19773191
66MP0001299_abnormal_eye_distance/1.19563906
67MP0009643_abnormal_urine_homeostasis1.18215857
68MP0002249_abnormal_larynx_morphology1.17376591
69MP0006036_abnormal_mitochondrial_physio1.15583449
70MP0003186_abnormal_redox_activity1.13561876
71MP0003941_abnormal_skin_development1.12578661
72MP0005636_abnormal_mineral_homeostasis1.11921454
73MP0005451_abnormal_body_composition1.10334845
74MP0006035_abnormal_mitochondrial_morpho1.09819965
75MP0003111_abnormal_nucleus_morphology1.09087238
76MP0002084_abnormal_developmental_patter1.08139125
77MP0002085_abnormal_embryonic_tissue1.07297154
78MP0002152_abnormal_brain_morphology1.07267063
79MP0003385_abnormal_body_wall1.07163694
80MP0001346_abnormal_lacrimal_gland1.05941516
81MP0003755_abnormal_palate_morphology1.04943312
82MP0005647_abnormal_sex_gland1.04825685
83MP0006276_abnormal_autonomic_nervous1.04613329
84MP0002557_abnormal_social/conspecific_i1.03576620
85MP0005084_abnormal_gallbladder_morpholo1.01471793
86MP0002111_abnormal_tail_morphology0.99802337
87MP0000598_abnormal_liver_morphology0.99477797
88MP0004858_abnormal_nervous_system0.99008110
89MP0003656_abnormal_erythrocyte_physiolo0.98346211
90MP0000631_abnormal_neuroendocrine_gland0.97993184
91MP0001188_hyperpigmentation0.96148458
92MP0002752_abnormal_somatic_nervous0.96115590
93MP0000604_amyloidosis0.95805232
94MP0004811_abnormal_neuron_physiology0.95565748
95MP0010094_abnormal_chromosome_stability0.95187018
96MP0000534_abnormal_ureter_morphology0.94626980
97MP0008058_abnormal_DNA_repair0.94382116
98MP0005248_abnormal_Harderian_gland0.92810461
99MP0001730_embryonic_growth_arrest0.92291785
100MP0002102_abnormal_ear_morphology0.91888691
101MP0008872_abnormal_physiological_respon0.90040395
102MP0004197_abnormal_fetal_growth/weight/0.89584694
103MP0005535_abnormal_body_temperature0.87990792
104MP0002089_abnormal_postnatal_growth/wei0.87954887
105MP0003077_abnormal_cell_cycle0.87777368
106MP0000026_abnormal_inner_ear0.87753521
107MP0002882_abnormal_neuron_morphology0.87547348
108MP0005391_vision/eye_phenotype0.87438695
109MP0002234_abnormal_pharynx_morphology0.86774041
110MP0005423_abnormal_somatic_nervous0.86669149
111MP0005376_homeostasis/metabolism_phenot0.85456194
112MP0002116_abnormal_craniofacial_bone0.85408731
113MP0009642_abnormal_blood_homeostasis0.83401371
114MP0003329_amyloid_beta_deposits0.83333985
115MP0003115_abnormal_respiratory_system0.82836069
116MP0002078_abnormal_glucose_homeostasis0.82684528
117MP0006072_abnormal_retinal_apoptosis0.82456963
118MP0002081_perinatal_lethality0.81391467
119MP0009703_decreased_birth_body0.81087655
120MP0005266_abnormal_metabolism0.80937429
121MP0001672_abnormal_embryogenesis/_devel0.80869560
122MP0005380_embryogenesis_phenotype0.80869560
123MP0008877_abnormal_DNA_methylation0.79287826
124MP0002734_abnormal_mechanical_nocicepti0.78879111
125MP0005408_hypopigmentation0.77335205
126MP0002254_reproductive_system_inflammat0.76908745
127MP0001697_abnormal_embryo_size0.75618190
128MP0003935_abnormal_craniofacial_develop0.73540103
129MP0003718_maternal_effect0.72737576
130MP0009765_abnormal_xenobiotic_induced0.72077552
131MP0002837_dystrophic_cardiac_calcinosis0.70634593
132MP0000639_abnormal_adrenal_gland0.70619324
133MP0009763_increased_sensitivity_to0.69985579
134MP0003880_abnormal_central_pattern0.67877698
135MP0001529_abnormal_vocalization0.66606008
136MP0005220_abnormal_exocrine_pancreas0.66121827
137MP0001756_abnormal_urination0.65545580
138MP0009764_decreased_sensitivity_to0.65005504
139MP0005448_abnormal_energy_balance0.62705442
140MP0009053_abnormal_anal_canal0.60808514
141MP0008874_decreased_physiological_sensi0.59926284
142MP0001968_abnormal_touch/_nociception0.57067128
143MP0008469_abnormal_protein_level0.56054702
144MP0003953_abnormal_hormone_level0.56026116
145MP0004142_abnormal_muscle_tone0.55373979
146MP0009745_abnormal_behavioral_response0.55274929
147MP0000538_abnormal_urinary_bladder0.54866994
148MP0009379_abnormal_foot_pigmentation0.54652851
149MP0002736_abnormal_nociception_after0.53615850
150MP0005334_abnormal_fat_pad0.52393157
151MP0003638_abnormal_response/metabolism_0.51479632
152MP0005646_abnormal_pituitary_gland0.48114886
153MP0002063_abnormal_learning/memory/cond0.47278605
154MP0005395_other_phenotype0.46719438
155MP0004043_abnormal_pH_regulation0.46644526
156MP0002069_abnormal_eating/drinking_beha0.46368597
157MP0001984_abnormal_olfaction0.46076639
158MP0001440_abnormal_grooming_behavior0.45679116
159MP0002572_abnormal_emotion/affect_behav0.44827934
160MP0002971_abnormal_brown_adipose0.44384039
161MP0001661_extended_life_span0.43804090
162MP0003635_abnormal_synaptic_transmissio0.43339182
163MP0005187_abnormal_penis_morphology0.43099045
164MP0001905_abnormal_dopamine_level0.41526144
165MP0002064_seizures0.40811800
166MP0009672_abnormal_birth_weight0.39330887
167MP0008873_increased_physiological_sensi0.39046938
168MP0002136_abnormal_kidney_physiology0.36890419
169MP0002735_abnormal_chemical_nociception0.36217685
170MP0002928_abnormal_bile_duct0.36200661
171MP0005386_behavior/neurological_phenoty0.35247405
172MP0004924_abnormal_behavior0.35247405
173MP0002733_abnormal_thermal_nociception0.33630037
174MP0010368_abnormal_lymphatic_system0.33450585
175MP0004270_analgesia0.32930138
176MP0000230_abnormal_systemic_arterial0.31728295
177MP0001765_abnormal_ion_homeostasis0.30868765
178MP0004883_abnormal_blood_vessel0.30663420
179MP0004130_abnormal_muscle_cell0.30522160
180MP0003879_abnormal_hair_cell0.28781245
181MP0001501_abnormal_sleep_pattern0.28675218

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33767054
2Intrahepatic cholestasis (HP:0001406)6.74742166
3Deep venous thrombosis (HP:0002625)6.71549056
4Hypobetalipoproteinemia (HP:0003563)6.44034160
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37136514
6Prolonged partial thromboplastin time (HP:0003645)6.14362990
7Xanthomatosis (HP:0000991)5.53820452
8Hyperlipoproteinemia (HP:0010980)4.97099687
9Hyperglycinemia (HP:0002154)4.70043300
10Complement deficiency (HP:0004431)4.52764442
11Hyperammonemia (HP:0001987)4.47652875
12Hypolipoproteinemia (HP:0010981)4.42088220
13Joint hemorrhage (HP:0005261)4.22984053
14Ketosis (HP:0001946)4.22826379
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13767734
16Hyperglycinuria (HP:0003108)4.12908545
17Abnormality of serine family amino acid metabolism (HP:0010894)4.02714784
18Abnormality of glycine metabolism (HP:0010895)4.02714784
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01036343
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.99776123
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95306424
22Epidermoid cyst (HP:0200040)3.94785662
23Abnormality of methionine metabolism (HP:0010901)3.94093376
24Abnormality of pyrimidine metabolism (HP:0004353)3.93202135
25Fat malabsorption (HP:0002630)3.80821507
26Abnormality of the common coagulation pathway (HP:0010990)3.80542913
27Conjugated hyperbilirubinemia (HP:0002908)3.71557522
28Cortical dysplasia (HP:0002539)3.67081130
29Hypoalphalipoproteinemia (HP:0003233)3.46972073
30Hepatoblastoma (HP:0002884)3.45597585
31Delayed CNS myelination (HP:0002188)3.36995645
32Hypoglycemic coma (HP:0001325)3.24293977
33Cerebral edema (HP:0002181)3.22727752
34Abnormality of the intrinsic pathway (HP:0010989)3.22179716
35Abnormality of serum amino acid levels (HP:0003112)3.21996588
36Hyperbilirubinemia (HP:0002904)3.20720292
37Abnormality of complement system (HP:0005339)3.15551023
38Ketoacidosis (HP:0001993)3.13561722
39Hypochromic microcytic anemia (HP:0004840)3.12515235
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11201417
41Abnormality of nucleobase metabolism (HP:0010932)3.10800661
42Abnormality of fatty-acid metabolism (HP:0004359)3.06262818
43Gout (HP:0001997)3.04773374
44Hypercholesterolemia (HP:0003124)3.04702602
45Lethargy (HP:0001254)3.02869821
46Metabolic acidosis (HP:0001942)2.91329563
47Spontaneous abortion (HP:0005268)2.89340401
48Steatorrhea (HP:0002570)2.78425635
49Abnormality of purine metabolism (HP:0004352)2.69599924
50Neonatal onset (HP:0003623)2.68401111
51High anterior hairline (HP:0009890)2.66106166
52Hepatocellular carcinoma (HP:0001402)2.65849146
53Reticulocytopenia (HP:0001896)2.64739766
54Abnormality of the labia minora (HP:0012880)2.63324499
55Abnormal gallbladder physiology (HP:0012438)2.60773591
56Cholecystitis (HP:0001082)2.60773591
57Colon cancer (HP:0003003)2.59411024
58Irritability (HP:0000737)2.58149155
59Skin nodule (HP:0200036)2.51251774
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47692508
61Dicarboxylic aciduria (HP:0003215)2.47692508
62Spastic diplegia (HP:0001264)2.44061466
63Brushfield spots (HP:0001088)2.42487985
64Hyperventilation (HP:0002883)2.38780378
65Anophthalmia (HP:0000528)2.38605859
66Malnutrition (HP:0004395)2.37656418
67Abnormal gallbladder morphology (HP:0012437)2.34584603
68Vomiting (HP:0002013)2.33315050
69Cholelithiasis (HP:0001081)2.31201752
70Acanthocytosis (HP:0001927)2.30796155
71Broad alveolar ridges (HP:0000187)2.30441594
72Acute encephalopathy (HP:0006846)2.29586921
73Septo-optic dysplasia (HP:0100842)2.28280591
74Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22584251
75Absent epiphyses (HP:0010577)2.22584251
76Status epilepticus (HP:0002133)2.21843517
77Hypoglycemic seizures (HP:0002173)2.20915200
78Sensorimotor neuropathy (HP:0007141)2.18515086
79Bifid tongue (HP:0010297)2.17872962
80Myokymia (HP:0002411)2.16390019
81Late onset (HP:0003584)2.14199830
82Increased serum pyruvate (HP:0003542)2.13386765
83Abnormality of glycolysis (HP:0004366)2.13386765
84Enlarged kidneys (HP:0000105)2.12539619
85Alkalosis (HP:0001948)2.12338307
86Vascular calcification (HP:0004934)2.11288343
87Trigonocephaly (HP:0000243)2.08035300
88Choanal stenosis (HP:0000452)2.06478585
89Partial duplication of thumb phalanx (HP:0009944)2.03648156
90Myelomeningocele (HP:0002475)2.03546328
91Opisthotonus (HP:0002179)2.02474379
92Rickets (HP:0002748)2.00453524
93Glycosuria (HP:0003076)1.99672985
94Abnormality of urine glucose concentration (HP:0011016)1.99672985
95Increased purine levels (HP:0004368)1.98196765
96Hyperuricemia (HP:0002149)1.98196765
97Abnormality of the gallbladder (HP:0005264)1.97825586
98Retinal dysplasia (HP:0007973)1.97182206
99Gait imbalance (HP:0002141)1.96027100
100Hemivertebrae (HP:0002937)1.95410143
101Generalized aminoaciduria (HP:0002909)1.94510923
102Generalized hypotonia (HP:0001290)1.94282778
103Glomerulonephritis (HP:0000099)1.92912330
104Hypophosphatemic rickets (HP:0004912)1.92383851
105Vaginal atresia (HP:0000148)1.90963972
106Vitreoretinal degeneration (HP:0000655)1.89752772
107Pancreatitis (HP:0001733)1.89516578
108Delayed myelination (HP:0012448)1.88476824
109Mitral stenosis (HP:0001718)1.87716017
110Hypoplastic pelvis (HP:0008839)1.86589387
111Renal hypoplasia (HP:0000089)1.86315798
112Systemic lupus erythematosus (HP:0002725)1.85501629
113Fair hair (HP:0002286)1.84650786
114Proximal tubulopathy (HP:0000114)1.84209080
115Poor suck (HP:0002033)1.83926698
116Confusion (HP:0001289)1.82633552
117Bilateral microphthalmos (HP:0007633)1.81759744
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81172483
119Broad foot (HP:0001769)1.79947180
120Hyperinsulinemic hypoglycemia (HP:0000825)1.79938563
121Congenital primary aphakia (HP:0007707)1.79768946
122Abnormality of cells of the erythroid lineage (HP:0012130)1.79637018
123Facial cleft (HP:0002006)1.79393728
124Genital tract atresia (HP:0001827)1.78286396
125Acute hepatic failure (HP:0006554)1.78217810
126Hepatic necrosis (HP:0002605)1.76012013
127Lissencephaly (HP:0001339)1.75493827
128Abnormality of vitamin metabolism (HP:0100508)1.75233681
129Menorrhagia (HP:0000132)1.74868213
130Abnormality of reticulocytes (HP:0004312)1.74404772
131Cardiovascular calcification (HP:0011915)1.74261029
132Scrotal hypoplasia (HP:0000046)1.73671928
133Amyloidosis (HP:0011034)1.73609021
134Thrombophlebitis (HP:0004418)1.73213538
135Myocardial infarction (HP:0001658)1.73108630
136Abnormal lung lobation (HP:0002101)1.72542913
137Duplication of thumb phalanx (HP:0009942)1.72502968
138Poikilocytosis (HP:0004447)1.72483465
139Renal duplication (HP:0000075)1.72401714
140Supernumerary spleens (HP:0009799)1.72301330
141Irregular epiphyses (HP:0010582)1.71987121
142Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71675933
143Hypoplasia of the brainstem (HP:0002365)1.71675933
144Nephrogenic diabetes insipidus (HP:0009806)1.71577766
145Bicornuate uterus (HP:0000813)1.67517932
146Increased nuchal translucency (HP:0010880)1.67393469
147Micropenis (HP:0000054)1.66236914
148Vaginal fistula (HP:0004320)1.65671122
149Horseshoe kidney (HP:0000085)1.62962328
150Abnormality of the intervertebral disk (HP:0005108)1.62525552
151Rib fusion (HP:0000902)1.61620971
152Polyphagia (HP:0002591)1.60759809
153Cutaneous syndactyly (HP:0012725)1.59837652
154Partial duplication of the phalanx of hand (HP:0009999)1.58962973
155Cutaneous finger syndactyly (HP:0010554)1.58775171
156Broad palm (HP:0001169)1.58704115
157Abnormality of the lower motor neuron (HP:0002366)1.58262461
158Synostosis involving the elbow (HP:0003938)1.58120111
159Humeroradial synostosis (HP:0003041)1.58120111
160Bifid scrotum (HP:0000048)1.56203854
161Amblyopia (HP:0000646)1.55476277
162Aplasia/Hypoplasia of the breasts (HP:0010311)1.55248951
163Diastasis recti (HP:0001540)1.54420153
164Failure to thrive in infancy (HP:0001531)1.54419844
165Poor coordination (HP:0002370)1.54339848
166Preaxial hand polydactyly (HP:0001177)1.54043486
167Absent eyebrow (HP:0002223)1.53053555
168Broad thumb (HP:0011304)1.52645701
169Abnormal number of erythroid precursors (HP:0012131)1.52366205
170Meckel diverticulum (HP:0002245)1.52343979
171Abnormality of the aortic arch (HP:0012303)1.52133484
172Breast aplasia (HP:0100783)1.51316864
173Drooling (HP:0002307)1.51181771
174Overriding aorta (HP:0002623)1.51076654
175Decreased testicular size (HP:0008734)1.49604700
176Macrocytic anemia (HP:0001972)1.49419351
177Medial flaring of the eyebrow (HP:0010747)1.47646911
178Occipital encephalocele (HP:0002085)1.45370715
179Specific learning disability (HP:0001328)1.45263940
180Aplasia/Hypoplasia of the sternum (HP:0006714)1.45169587
181Abnormality of the ileum (HP:0001549)1.44815507
182Renal dysplasia (HP:0000110)1.44797646
183Stenosis of the external auditory canal (HP:0000402)1.44625700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.64819018
2MAP2K43.68684656
3FGFR43.17610338
4EPHA43.01636857
5DAPK22.77284687
6SIK12.76140875
7ERBB42.75285957
8SRPK12.60082010
9MAP3K42.58984536
10INSRR2.45982275
11CASK2.30341953
12VRK22.26363632
13MAP3K122.25925336
14MAP2K72.25411932
15CDC72.10276830
16DAPK12.07280191
17WNK32.06023673
18TRIM281.93587117
19MAP3K101.91200151
20GRK61.87295592
21NTRK31.81610715
22TAOK31.75459217
23MARK11.68620833
24DYRK31.65855622
25PASK1.65211263
26MKNK11.60511479
27ERN11.51422527
28NEK11.50350686
29MINK11.46436517
30STK161.45603660
31MST1R1.45211654
32EEF2K1.43463643
33FLT31.38358859
34EPHB21.37684282
35CSNK1A1L1.36589513
36TTK1.36299676
37MAPK111.36144474
38TSSK61.34627367
39PRKCG1.34478628
40ICK1.30826273
41TYRO31.29744794
42GRK51.28249292
43BUB11.28145090
44ABL21.23721617
45AKT31.20207538
46STK38L1.16398582
47PRKD31.15696910
48PRKCZ1.14128710
49SIK31.13813135
50PLK31.12817570
51SMG11.12400266
52PINK11.11762670
53NEK21.07537415
54TAF11.06230855
55KSR11.05452138
56CDK71.04138590
57MAP3K91.03913852
58EPHA21.03269110
59CSNK1G21.00300922
60CDK11A0.99242094
61ZAK0.97932804
62MAPK40.96948752
63CSNK1G30.96514114
64CDK180.96202774
65VRK10.95713467
66BRSK10.95556012
67FGFR10.94508312
68CDK150.93760173
69PLK10.93754853
70CDK140.91999595
71MAP4K20.89301944
72MAP2K60.88270963
73PLK40.87295502
74FRK0.86934293
75CHEK20.86828081
76OXSR10.85107648
77RPS6KA40.84577729
78SGK20.84524910
79SGK4940.83440577
80SGK2230.83440577
81TESK20.82910164
82ADRBK20.82842529
83ATR0.81042431
84NME10.80955722
85LATS20.80808222
86DYRK20.80474195
87PBK0.80373543
88PIK3CG0.79360251
89TNIK0.79104780
90CAMK2G0.79012796
91CSNK1G10.77244978
92DYRK1A0.77066094
93UHMK10.73518106
94ERBB20.73181531
95LIMK10.71544631
96PRKACG0.71217906
97MAP3K60.70901685
98MAP3K110.70896218
99NTRK20.69909197
100ARAF0.69209393
101PNCK0.69003216
102KSR20.68735911
103AURKB0.68482932
104MAPK120.68290786
105MKNK20.65992649
106BRAF0.65529946
107FGFR20.64332726
108EIF2AK10.63172405
109PKN20.61612630
110BRD40.61294599
111ACVR1B0.60357098
112MAP2K10.59580488
113MAPK130.59335985
114PDK40.59016172
115PDK30.59016172
116CCNB10.58577147
117CHEK10.56714525
118CAMK2A0.56172193
119PLK20.55039530
120CDK20.54816328
121WEE10.54753411
122TESK10.54693068
123MAP3K70.54598269
124WNK40.53590199
125NTRK10.53346343
126PAK40.52558296
127CAMK1D0.51917610
128CDK10.51241173
129SIK20.50690622
130ADRBK10.50079448
131ATM0.49340453
132CSNK1E0.46393402
133PRKDC0.46227806
134CAMK40.44769456
135CAMK2B0.44236003
136EPHA30.43637016
137TAOK20.43244394
138SGK30.43143239
139BMPR20.42550460
140RPS6KB20.42338249
141PRKAA10.42215618
142CSNK2A10.41536943
143PRKACA0.41503561
144JAK20.41322074
145CSNK1A10.40996080
146PRKAA20.39869636
147AKT20.39868964
148CDK190.39798508
149CDK80.39709416
150MAPKAPK30.39248041
151RPS6KB10.39204684
152AURKA0.37755971
153BCR0.37018185
154PRKCA0.35822242
155DYRK1B0.34507255
156CSNK2A20.34275480
157GRK70.34019408
158GSK3A0.33615563
159CDK50.33242811
160DAPK30.31592421
161KDR0.30870783
162RET0.30870742

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33925434
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56721078
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33872516
4Nitrogen metabolism_Homo sapiens_hsa009103.14275496
5Arginine biosynthesis_Homo sapiens_hsa002203.03664781
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86987519
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75060155
8Tryptophan metabolism_Homo sapiens_hsa003802.69474530
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56691443
10Complement and coagulation cascades_Homo sapiens_hsa046102.41006906
11Butanoate metabolism_Homo sapiens_hsa006502.40834541
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38920453
13Fatty acid degradation_Homo sapiens_hsa000712.29367258
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17746209
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07784154
16Peroxisome_Homo sapiens_hsa041462.07489961
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05042501
18Propanoate metabolism_Homo sapiens_hsa006401.98056706
19Ribosome_Homo sapiens_hsa030101.97858614
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89728087
21Histidine metabolism_Homo sapiens_hsa003401.86052045
22Chemical carcinogenesis_Homo sapiens_hsa052041.85143155
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84093977
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82282031
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.82128786
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81044709
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.79865752
28Phenylalanine metabolism_Homo sapiens_hsa003601.72074795
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69316761
30Pyruvate metabolism_Homo sapiens_hsa006201.69077011
31beta-Alanine metabolism_Homo sapiens_hsa004101.68180512
32Fatty acid metabolism_Homo sapiens_hsa012121.66045347
33PPAR signaling pathway_Homo sapiens_hsa033201.60037730
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59126428
35Tyrosine metabolism_Homo sapiens_hsa003501.58003781
36Retinol metabolism_Homo sapiens_hsa008301.57970302
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.49828979
38Base excision repair_Homo sapiens_hsa034101.48604368
39Selenocompound metabolism_Homo sapiens_hsa004501.47246439
40DNA replication_Homo sapiens_hsa030301.46037005
41Bile secretion_Homo sapiens_hsa049761.45681776
42Spliceosome_Homo sapiens_hsa030401.40063151
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37700910
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.36947392
45Sulfur metabolism_Homo sapiens_hsa009201.35289025
46Biosynthesis of amino acids_Homo sapiens_hsa012301.34361028
47Mismatch repair_Homo sapiens_hsa034301.31859408
48Fatty acid elongation_Homo sapiens_hsa000621.29115070
49Carbon metabolism_Homo sapiens_hsa012001.26046561
50Caffeine metabolism_Homo sapiens_hsa002321.24341086
51Staphylococcus aureus infection_Homo sapiens_hsa051501.21421448
52Basal cell carcinoma_Homo sapiens_hsa052171.19872165
53Folate biosynthesis_Homo sapiens_hsa007901.18027394
54RNA transport_Homo sapiens_hsa030131.13367889
55Starch and sucrose metabolism_Homo sapiens_hsa005001.11828463
56RNA polymerase_Homo sapiens_hsa030201.05340881
57Steroid biosynthesis_Homo sapiens_hsa001001.04768334
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.04070139
59Fat digestion and absorption_Homo sapiens_hsa049751.01516043
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00646953
61mRNA surveillance pathway_Homo sapiens_hsa030150.97829104
62Sulfur relay system_Homo sapiens_hsa041220.97028559
63Arginine and proline metabolism_Homo sapiens_hsa003300.96633748
64Hippo signaling pathway_Homo sapiens_hsa043900.95290492
65ABC transporters_Homo sapiens_hsa020100.93107506
66Vitamin B6 metabolism_Homo sapiens_hsa007500.93103837
67Axon guidance_Homo sapiens_hsa043600.91553384
68Non-homologous end-joining_Homo sapiens_hsa034500.89297119
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88986028
70Protein export_Homo sapiens_hsa030600.87280349
71One carbon pool by folate_Homo sapiens_hsa006700.86157863
72Hedgehog signaling pathway_Homo sapiens_hsa043400.85756439
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85726476
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83253778
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80020505
76Nucleotide excision repair_Homo sapiens_hsa034200.79960519
77Vitamin digestion and absorption_Homo sapiens_hsa049770.75166957
78Cell cycle_Homo sapiens_hsa041100.73382090
79Fanconi anemia pathway_Homo sapiens_hsa034600.69808985
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66311579
81Glutathione metabolism_Homo sapiens_hsa004800.64569387
82Lysine degradation_Homo sapiens_hsa003100.64104077
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.63367758
84RNA degradation_Homo sapiens_hsa030180.62368587
85Basal transcription factors_Homo sapiens_hsa030220.61703669
86Wnt signaling pathway_Homo sapiens_hsa043100.60249982
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59502933
88Glycerolipid metabolism_Homo sapiens_hsa005610.58960514
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58746322
90Cardiac muscle contraction_Homo sapiens_hsa042600.57235676
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56930581
92Metabolic pathways_Homo sapiens_hsa011000.56608643
93Tight junction_Homo sapiens_hsa045300.52324716
94Pentose phosphate pathway_Homo sapiens_hsa000300.49069179
95Oxidative phosphorylation_Homo sapiens_hsa001900.46499766
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45904162
97N-Glycan biosynthesis_Homo sapiens_hsa005100.44330097
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39319464
99Fructose and mannose metabolism_Homo sapiens_hsa000510.33870646
100Parkinsons disease_Homo sapiens_hsa050120.32541068
101Prion diseases_Homo sapiens_hsa050200.29553813
102Fatty acid biosynthesis_Homo sapiens_hsa000610.26475107
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25298803
104Galactose metabolism_Homo sapiens_hsa000520.23291119
105Glucagon signaling pathway_Homo sapiens_hsa049220.15115740
106Alzheimers disease_Homo sapiens_hsa050100.14760223
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13502283
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11030488
109Nicotine addiction_Homo sapiens_hsa050330.10039290
110Linoleic acid metabolism_Homo sapiens_hsa005910.09558919
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.09212181
112Huntingtons disease_Homo sapiens_hsa050160.04458326
113Collecting duct acid secretion_Homo sapiens_hsa049660.03175066
114African trypanosomiasis_Homo sapiens_hsa05143-0.1755549
115Taste transduction_Homo sapiens_hsa04742-0.1620099
116Amphetamine addiction_Homo sapiens_hsa05031-0.1613768
117Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1442352
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1264128
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1173123
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1027142
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0986981
122Regulation of autophagy_Homo sapiens_hsa04140-0.0792409
123Proteasome_Homo sapiens_hsa03050-0.0763393
124Pyrimidine metabolism_Homo sapiens_hsa00240-0.0747994
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0714571
126Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0329332
127GABAergic synapse_Homo sapiens_hsa04727-0.0143398
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0112713
129Insulin resistance_Homo sapiens_hsa04931-0.0079817
130Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0060159

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