NIPAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.37532830
2ensheathment of neurons (GO:0007272)6.92567746
3axon ensheathment (GO:0008366)6.92567746
4long-chain fatty acid biosynthetic process (GO:0042759)6.92306748
5myelination (GO:0042552)6.89332231
6regulation of vitamin D biosynthetic process (GO:0060556)6.48427389
7regulation of chronic inflammatory response (GO:0002676)5.66697990
8regulation of T-helper 1 cell differentiation (GO:0045625)5.39924576
9regulation of cytokine secretion involved in immune response (GO:0002739)5.25792825
10cholesterol biosynthetic process (GO:0006695)5.11973821
11regulation of vitamin metabolic process (GO:0030656)5.10634933
12negative regulation of neurotransmitter secretion (GO:0046929)4.93906603
13negative regulation of interleukin-12 production (GO:0032695)4.90509937
14positive regulation of heat generation (GO:0031652)4.85141261
15regulation of fever generation (GO:0031620)4.79856814
16branching involved in labyrinthine layer morphogenesis (GO:0060670)4.74286730
17oligodendrocyte differentiation (GO:0048709)4.63395935
18myelin maintenance (GO:0043217)4.61918719
19photoreceptor cell differentiation (GO:0046530)4.59956123
20eye photoreceptor cell differentiation (GO:0001754)4.59956123
21positive regulation of chemokine biosynthetic process (GO:0045080)4.59742724
22negative regulation of neurotransmitter transport (GO:0051589)4.50190749
23sterol biosynthetic process (GO:0016126)4.44240930
24glycerophospholipid catabolic process (GO:0046475)4.43748981
25regulation of interferon-alpha production (GO:0032647)4.43476163
26regulation of podosome assembly (GO:0071801)4.40423519
27regulation of collateral sprouting (GO:0048670)4.37539578
28negative regulation of protein localization to cell surface (GO:2000009)4.34666578
29presynaptic membrane organization (GO:0097090)4.30330715
30response to peptidoglycan (GO:0032494)4.30254342
31type I interferon signaling pathway (GO:0060337)4.30113552
32cellular response to type I interferon (GO:0071357)4.30113552
33response to type I interferon (GO:0034340)4.23673178
34regulation of chemokine biosynthetic process (GO:0045073)4.22192079
35presynaptic membrane assembly (GO:0097105)4.20463328
36adhesion of symbiont to host cell (GO:0044650)4.19896874
37virion attachment to host cell (GO:0019062)4.19896874
38long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.17003951
39lipopolysaccharide-mediated signaling pathway (GO:0031663)4.15093319
40negative regulation of nitric oxide biosynthetic process (GO:0045019)4.13130123
41long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.07317281
42creatine metabolic process (GO:0006600)4.02022434
43regulation of membrane protein ectodomain proteolysis (GO:0051043)4.00438623
44negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.99205560
45isoprenoid biosynthetic process (GO:0008299)3.95228210
46apical protein localization (GO:0045176)3.94605622
47amyloid precursor protein metabolic process (GO:0042982)3.93488210
48substantia nigra development (GO:0021762)3.93144950
49asymmetric protein localization (GO:0008105)3.90233498
50myeloid dendritic cell differentiation (GO:0043011)3.89043553
51activation of MAPKKK activity (GO:0000185)3.88035741
52peptidyl-tyrosine autophosphorylation (GO:0038083)3.84127383
53astrocyte development (GO:0014002)3.83606791
54negative regulation of cytokine production involved in immune response (GO:0002719)3.81369067
55positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.81125053
56establishment of mitochondrion localization (GO:0051654)3.80405248
57response to methylmercury (GO:0051597)3.75535713
58negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.72973264
59regulation of immunoglobulin secretion (GO:0051023)3.72179052
60T-helper 1 type immune response (GO:0042088)3.68614804
61regulation of heat generation (GO:0031650)3.66358254
62response to protozoan (GO:0001562)3.66322386
63regulation of nitric oxide biosynthetic process (GO:0045428)3.65665066
64macrophage activation involved in immune response (GO:0002281)3.64978925
65NIK/NF-kappaB signaling (GO:0038061)3.62753547
66import into cell (GO:0098657)3.60326663
67defense response to protozoan (GO:0042832)3.59255138
68L-amino acid import (GO:0043092)3.58496701
69fatty-acyl-CoA biosynthetic process (GO:0046949)3.58451404
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.56224188
71regulation of mononuclear cell migration (GO:0071675)3.55924919
72germinal center formation (GO:0002467)3.55185066
73peripheral nervous system axon ensheathment (GO:0032292)3.54272419
74myelination in peripheral nervous system (GO:0022011)3.54272419
75limb bud formation (GO:0060174)3.53523712
76positive regulation of nitric oxide biosynthetic process (GO:0045429)3.48597901
77fatty-acyl-CoA metabolic process (GO:0035337)3.46333041
78negative regulation of amino acid transport (GO:0051956)3.45932223
79response to redox state (GO:0051775)3.44409523
80interferon-gamma-mediated signaling pathway (GO:0060333)3.39499462
81cerebral cortex radially oriented cell migration (GO:0021799)3.39472884
82response to lipoprotein particle (GO:0055094)3.39441631
83positive regulation of oligodendrocyte differentiation (GO:0048714)3.38610033
84negative regulation of execution phase of apoptosis (GO:1900118)3.36417833
85negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.36371526
86positive regulation of interferon-alpha production (GO:0032727)3.36042378
87positive regulation of NF-kappaB import into nucleus (GO:0042346)3.35286841
88regulation of interleukin-8 biosynthetic process (GO:0045414)3.32328264
89positive regulation of action potential (GO:0045760)3.30677507
90cellular response to lipopolysaccharide (GO:0071222)3.26994431
91regulation of heterotypic cell-cell adhesion (GO:0034114)3.25142142
92positive regulation of type 2 immune response (GO:0002830)3.23944695
93positive regulation of interleukin-6 production (GO:0032755)3.23569980
94immunoglobulin mediated immune response (GO:0016064)3.23177583
95myeloid dendritic cell activation (GO:0001773)3.22834255
96protein palmitoylation (GO:0018345)3.22090758
97GPI anchor biosynthetic process (GO:0006506)3.19888501
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19341737
99negative regulation of lipid storage (GO:0010888)3.19268644
100monocyte chemotaxis (GO:0002548)3.17613523
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16179225
102cellular response to molecule of bacterial origin (GO:0071219)3.14687011
103response to muramyl dipeptide (GO:0032495)3.11624355
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11123875
105regulation of NF-kappaB import into nucleus (GO:0042345)3.10814465
106GPI anchor metabolic process (GO:0006505)3.10613066
107regulation of interleukin-12 production (GO:0032655)3.09577850
108negative regulation of axonogenesis (GO:0050771)3.08808641
109negative regulation of production of molecular mediator of immune response (GO:0002701)3.07648635
110cellular response to nicotine (GO:0071316)3.04962925
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04031880
112positive regulation of acute inflammatory response (GO:0002675)3.03378049
113modulation of growth of symbiont involved in interaction with host (GO:0044144)3.02818945
114regulation of growth of symbiont in host (GO:0044126)3.02818945
115negative regulation of growth of symbiont in host (GO:0044130)3.02818945
116negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.02818945
117peripheral nervous system development (GO:0007422)3.01977071
118regulation of inflammatory response to antigenic stimulus (GO:0002861)3.01659479
119adhesion of symbiont to host (GO:0044406)3.01465935
120very long-chain fatty acid metabolic process (GO:0000038)3.01181381
121regulation of T-helper cell differentiation (GO:0045622)3.00526625
122glycosphingolipid catabolic process (GO:0046479)3.00114392
123regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99932428
124adult walking behavior (GO:0007628)2.99653167
125regulation of T-helper 2 cell differentiation (GO:0045628)2.99649804
126glycosylceramide metabolic process (GO:0006677)2.99559339
127regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.99424204
128negative regulation of viral genome replication (GO:0045071)2.98894662
129dendritic cell differentiation (GO:0097028)2.98076950
130interleukin-6-mediated signaling pathway (GO:0070102)2.97207183
131nucleotide transmembrane transport (GO:1901679)2.95012316
132membrane tubulation (GO:0097320)2.94679606
133positive regulation of natural killer cell differentiation (GO:0032825)2.93405165
134regulation of natural killer cell activation (GO:0032814)2.93229306
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.93032104
136transmission of nerve impulse (GO:0019226)2.92601339
137cellular response to epinephrine stimulus (GO:0071872)2.91592151
138oligosaccharide catabolic process (GO:0009313)2.91576584
139detection of other organism (GO:0098543)2.90132109
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.90046437
141leukocyte migration involved in inflammatory response (GO:0002523)2.88743892
142regulation of somitogenesis (GO:0014807)2.87757694
143positive regulation of lymphocyte apoptotic process (GO:0070230)2.87131157
144positive regulation of cellular amine metabolic process (GO:0033240)2.86560249
145regulation of interleukin-6 production (GO:0032675)2.85215539
146regulation of type 2 immune response (GO:0002828)2.84894347
147regulation of lipoprotein metabolic process (GO:0050746)2.84495676
148membrane assembly (GO:0071709)2.83431521
149positive regulation of gamma-delta T cell activation (GO:0046645)2.83175550
150neuron remodeling (GO:0016322)2.81690849
151positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.79802853
152positive regulation of hair cycle (GO:0042635)2.78993793
153positive regulation of hair follicle development (GO:0051798)2.78993793
154positive regulation of interferon-beta production (GO:0032728)2.78727464
155axon development (GO:0061564)2.78554850
156cellular response to interferon-gamma (GO:0071346)2.78198972
157detection of bacterium (GO:0016045)2.77813103
158positive regulation of monocyte chemotaxis (GO:0090026)2.77779139
159positive regulation of T-helper cell differentiation (GO:0045624)2.77296774
160positive regulation of p38MAPK cascade (GO:1900745)2.77206322
161sphingosine metabolic process (GO:0006670)2.76807439
162regulation of interferon-beta biosynthetic process (GO:0045357)2.76776835
163negative regulation of axon extension (GO:0030517)2.76693796
164regulation of interferon-gamma biosynthetic process (GO:0045072)2.75449889
165amyloid precursor protein catabolic process (GO:0042987)2.75006369
166response to epinephrine (GO:0071871)2.73977514
167acyl-CoA biosynthetic process (GO:0071616)2.73138443
168thioester biosynthetic process (GO:0035384)2.73138443
169preassembly of GPI anchor in ER membrane (GO:0016254)2.73044155
170positive regulation of actin filament depolymerization (GO:0030836)2.71095707
171organ growth (GO:0035265)2.69987618
172neural nucleus development (GO:0048857)2.68659453
173negative regulation of JUN kinase activity (GO:0043508)2.67600766
174ear development (GO:0043583)2.65934153
175neuronal ion channel clustering (GO:0045161)2.64484897
176positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.60907768
177glial cell differentiation (GO:0010001)2.60895037
178positive regulation of glial cell differentiation (GO:0045687)2.60515530
179keratinization (GO:0031424)2.59300887
180positive regulation of cell fate commitment (GO:0010455)2.58547754
181neuron cell-cell adhesion (GO:0007158)2.54359079
182phosphatidylserine acyl-chain remodeling (GO:0036150)2.53919672
183ceramide biosynthetic process (GO:0046513)2.53543160
184glial cell development (GO:0021782)2.52431679
185cranial nerve development (GO:0021545)2.51524436
186enteric nervous system development (GO:0048484)2.50983080
187amino acid import (GO:0043090)2.50609286
188glutathione biosynthetic process (GO:0006750)2.49588682
189lateral sprouting from an epithelium (GO:0060601)2.48819063
190negative regulation of macroautophagy (GO:0016242)2.47878406
191positive regulation of gliogenesis (GO:0014015)2.46517828
192phosphatidylserine metabolic process (GO:0006658)2.46489419
193peptidyl-cysteine modification (GO:0018198)2.46109767
194Leydig cell differentiation (GO:0033327)2.43467859
195axon ensheathment in central nervous system (GO:0032291)11.1206254
196central nervous system myelination (GO:0022010)11.1206254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.23807610
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.65103595
3RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.21894706
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.80606763
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.75651734
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.41081757
7GBX2_23144817_ChIP-Seq_PC3_Human3.22402073
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.21039013
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02019258
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95327790
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.84509945
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81814737
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52411465
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48248191
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.44915490
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44422611
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44325939
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44150763
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43401682
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36681728
21TAF15_26573619_Chip-Seq_HEK293_Human2.32726764
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30234772
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26767959
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21747058
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21540183
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20351555
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.15504380
28VDR_22108803_ChIP-Seq_LS180_Human2.10780574
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07573250
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06819953
31ESR2_21235772_ChIP-Seq_MCF-7_Human2.01591423
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.01379787
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00900432
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96743021
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94226102
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.94121199
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91148764
38AR_21572438_ChIP-Seq_LNCaP_Human1.90536010
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89964761
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88964122
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88964122
42VDR_24787735_ChIP-Seq_THP-1_Human1.86937626
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84713085
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84232487
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81177294
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80230895
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79369217
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77682893
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76349613
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.72058303
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70621194
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70297748
53ER_23166858_ChIP-Seq_MCF-7_Human1.70103750
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68774872
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67707854
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.67492605
57EZH2_22144423_ChIP-Seq_EOC_Human1.66658656
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66577570
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66285043
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59142023
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.57609055
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56116372
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.55973121
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54731851
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54703599
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.54442894
67VDR_24763502_ChIP-Seq_THP-1_Human1.53993727
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53534817
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.52380944
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48873665
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45053302
72VDR_21846776_ChIP-Seq_THP-1_Human1.43852998
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.42568855
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41042151
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.39174020
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38722466
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.37912170
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37532670
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36795391
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36200414
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36125335
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35631385
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35065594
84SPI1_23127762_ChIP-Seq_K562_Human1.34004721
85FUS_26573619_Chip-Seq_HEK293_Human1.31910915
86* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31103344
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28616069
88DROSHA_22980978_ChIP-Seq_HELA_Human1.28457686
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25703199
90LXR_22292898_ChIP-Seq_THP-1_Human1.24473238
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24134240
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23866018
93P300_19829295_ChIP-Seq_ESCs_Human1.23456690
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22958662
95* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22488521
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21685737
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21116148
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.20087480
99PU_27001747_Chip-Seq_BMDM_Mouse1.20019750
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18939697
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17252381
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.16583771
103RNF2_27304074_Chip-Seq_NSC_Mouse1.16532537
104HTT_18923047_ChIP-ChIP_STHdh_Human1.16508429
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.16482988
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15922411
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.15615159
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14122439
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13877873
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13877873
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13360344
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13360344
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13014798
114RUNX_20019798_ChIP-Seq_JUKART_Human1.12991928
115MAF_26560356_Chip-Seq_TH1_Human1.12539327
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12473821
117GATA1_22025678_ChIP-Seq_K562_Human1.11926797
118EGR1_19032775_ChIP-ChIP_M12_Human1.11166667
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10472628
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10071695
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09620779
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09377301
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08123383
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08095654
125* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07627023
126SPI1_23547873_ChIP-Seq_NB4_Human1.07601365
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07458132
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07395278
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07258218
130KDM2B_26808549_Chip-Seq_DND41_Human1.07156858
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06983214
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06925251
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06816207
134SCL_19346495_ChIP-Seq_HPC-7_Human1.06720399
135P300_18555785_Chip-Seq_ESCs_Mouse1.06691928
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06412274
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05450144
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05197376
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03549617
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03470975
141* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02880807
142STAT3_23295773_ChIP-Seq_U87_Human1.02318085
143EP300_21415370_ChIP-Seq_HL-1_Mouse1.01697444
144TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01603741
145PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01572529
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01458440
147GATA1_19941826_ChIP-Seq_K562_Human1.01246896
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00742193
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00674322
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99320794
151TCF7_22412390_ChIP-Seq_EML_Mouse0.99234408
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98398067
153KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98341962
154* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98104537
155TP53_16413492_ChIP-PET_HCT116_Human0.97769297
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.97651638
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97396176
158UBF1/2_26484160_Chip-Seq_HMECs_Human0.97234177
159TP53_18474530_ChIP-ChIP_U2OS_Human0.96801087
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96793507
161STAT1_20625510_ChIP-Seq_HELA_Human0.96681074
162SOX2_20726797_ChIP-Seq_SW620_Human0.95809966
163KDM2B_26808549_Chip-Seq_K562_Human0.95109896
164P53_22387025_ChIP-Seq_ESCs_Mouse0.94625240
165EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93730416
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93633775
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.93406980
168E2F1_18555785_Chip-Seq_ESCs_Mouse0.93148317
169KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93110646
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93110646
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93110646
172POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92515249
173RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92393654
174SMAD4_21799915_ChIP-Seq_A2780_Human0.92107804
175RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92020123
176RACK7_27058665_Chip-Seq_MCF-7_Human0.92013927
177TBL1_22424771_ChIP-Seq_293T_Human0.91910425
178KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91561029
179TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91162870
180SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91085184
181TCF4_23295773_ChIP-Seq_U87_Human0.91050329
182LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90805720
183EZH2_27294783_Chip-Seq_NPCs_Mouse0.90249749
184AHR_22903824_ChIP-Seq_MCF-7_Human0.90112941
185SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90068431
186MYB_26560356_Chip-Seq_TH2_Human0.85947264
187PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85171730
188PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84438262
189GATA1_19941827_ChIP-Seq_MEL_Mouse0.84311730
190TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79532258
191BCOR_27268052_Chip-Seq_Bcells_Human0.76942843
192ZNF263_19887448_ChIP-Seq_K562_Human0.74265258
193BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72966922
194SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72342086
195MAF_26560356_Chip-Seq_TH2_Human0.72336423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.10164937
2MP0000920_abnormal_myelination5.19026793
3MP0003950_abnormal_plasma_membrane3.89813959
4MP0004510_myositis3.81513935
5MP0003880_abnormal_central_pattern3.72850868
6MP0002148_abnormal_hypersensitivity_rea3.45927717
7MP0003724_increased_susceptibility_to3.44779159
8MP0003136_yellow_coat_color3.30584303
9MP0009785_altered_susceptibility_to3.17741992
10MP0003436_decreased_susceptibility_to3.13348099
11MP0005058_abnormal_lysosome_morphology3.06860937
12MP0004381_abnormal_hair_follicle3.00288905
13MP0010678_abnormal_skin_adnexa2.89570133
14MP0004270_analgesia2.86436595
15MP0003690_abnormal_glial_cell2.82331996
16MP0004742_abnormal_vestibular_system2.78882218
17MP0000383_abnormal_hair_follicle2.77471910
18MP0003300_gastrointestinal_ulcer2.71929871
19MP0005171_absent_coat_pigmentation2.71261612
20MP0005409_darkened_coat_color2.64206213
21MP0005451_abnormal_body_composition2.64175787
22MP0004947_skin_inflammation2.63625869
23MP0001835_abnormal_antigen_presentation2.62236810
24MP0005387_immune_system_phenotype2.54738877
25MP0001790_abnormal_immune_system2.54738877
26MP0005000_abnormal_immune_tolerance2.52180353
27MP0001529_abnormal_vocalization2.42734462
28MP0004885_abnormal_endolymph2.40243239
29MP0005671_abnormal_response_to2.39862744
30MP0002139_abnormal_hepatobiliary_system2.35120680
31MP0009764_decreased_sensitivity_to2.34845114
32MP0008004_abnormal_stomach_pH2.25358945
33MP0005025_abnormal_response_to2.24454248
34MP0003329_amyloid_beta_deposits2.24141479
35MP0001486_abnormal_startle_reflex2.22046790
36MP0001905_abnormal_dopamine_level2.21075699
37MP0009840_abnormal_foam_cell2.20024117
38MP0002796_impaired_skin_barrier2.19450104
39MP0001485_abnormal_pinna_reflex2.18332724
40MP0003075_altered_response_to2.17825655
41MP0002419_abnormal_innate_immunity2.12665648
42MP0004142_abnormal_muscle_tone2.11435645
43MP0002272_abnormal_nervous_system2.09099670
44MP0003634_abnormal_glial_cell2.05661735
45MP0002254_reproductive_system_inflammat2.04860927
46MP0006054_spinal_hemorrhage2.03393488
47MP0001533_abnormal_skeleton_physiology2.03002542
48MP0000579_abnormal_nail_morphology2.01533276
49MP0002332_abnormal_exercise_endurance2.00471757
50MP0000778_abnormal_nervous_system1.98510086
51MP0000647_abnormal_sebaceous_gland1.88760089
52MP0002723_abnormal_immune_serum1.88006327
53MP0002452_abnormal_antigen_presenting1.87294058
54MP0000566_synostosis1.84834786
55MP0001853_heart_inflammation1.84391019
56MP0001800_abnormal_humoral_immune1.79738386
57MP0001346_abnormal_lacrimal_gland1.77997239
58MP0000343_altered_response_to1.73004135
59MP0010155_abnormal_intestine_physiology1.72399879
60MP0003632_abnormal_nervous_system1.70174108
61MP0002064_seizures1.69809159
62MP0000462_abnormal_digestive_system1.61658485
63MP0002229_neurodegeneration1.60344942
64MP0003191_abnormal_cellular_cholesterol1.57487840
65MP0003448_altered_tumor_morphology1.57230265
66MP0009278_abnormal_bone_marrow1.56867561
67MP0001845_abnormal_inflammatory_respons1.56505914
68MP0005410_abnormal_fertilization1.56338769
69MP0005167_abnormal_blood-brain_barrier1.49748070
70MP0009046_muscle_twitch1.45480514
71MP0008469_abnormal_protein_level1.45204985
72MP0003172_abnormal_lysosome_physiology1.43984278
73MP0001819_abnormal_immune_cell1.43912361
74MP0000467_abnormal_esophagus_morphology1.43912211
75MP0000762_abnormal_tongue_morphology1.43080957
76MP0002420_abnormal_adaptive_immunity1.42665782
77MP0005275_abnormal_skin_tensile1.41061782
78MP0004134_abnormal_chest_morphology1.38040737
79MP0001545_abnormal_hematopoietic_system1.37331439
80MP0005397_hematopoietic_system_phenotyp1.37331439
81MP0003806_abnormal_nucleotide_metabolis1.36086329
82MP0002734_abnormal_mechanical_nocicepti1.35168556
83MP0002098_abnormal_vibrissa_morphology1.34650285
84MP0005310_abnormal_salivary_gland1.33718604
85MP0000685_abnormal_immune_system1.33663606
86MP0001851_eye_inflammation1.32909262
87MP0002405_respiratory_system_inflammati1.30157133
88MP0005423_abnormal_somatic_nervous1.29971911
89MP0002998_abnormal_bone_remodeling1.29692248
90MP0005551_abnormal_eye_electrophysiolog1.27447622
91MP0009745_abnormal_behavioral_response1.24953808
92MP0005166_decreased_susceptibility_to1.24074307
93MP0009333_abnormal_splenocyte_physiolog1.23915630
94MP0000858_altered_metastatic_potential1.19175002
95MP0001542_abnormal_bone_strength1.18794886
96MP0005501_abnormal_skin_physiology1.18476717
97MP0002882_abnormal_neuron_morphology1.16375416
98MP0000955_abnormal_spinal_cord1.15930618
99MP0005023_abnormal_wound_healing1.13355257
100MP0004147_increased_porphyrin_level1.12259640
101MP0003941_abnormal_skin_development1.12132947
102MP0001963_abnormal_hearing_physiology1.11888133
103MP0003631_nervous_system_phenotype1.11853345
104MP0004859_abnormal_synaptic_plasticity1.10553383
105MP0003635_abnormal_synaptic_transmissio1.10114317
106MP0003938_abnormal_ear_development1.09456825
107MP0008260_abnormal_autophagy1.07759788
108MP0001501_abnormal_sleep_pattern1.05563640
109MP0002752_abnormal_somatic_nervous1.03838903
110MP0001440_abnormal_grooming_behavior1.03792176
111MP0010771_integument_phenotype1.02519420
112MP0003656_abnormal_erythrocyte_physiolo1.02350778
113MP0003937_abnormal_limbs/digits/tail_de1.02118739
114MP0008569_lethality_at_weaning1.01985749
115MP0005165_increased_susceptibility_to1.01749781
116MP0004043_abnormal_pH_regulation0.99452165
117MP0001299_abnormal_eye_distance/0.99105393
118MP0000377_abnormal_hair_follicle0.98833438
119MP0003091_abnormal_cell_migration0.98404448
120MP0003453_abnormal_keratinocyte_physiol0.97893998
121MP0000716_abnormal_immune_system0.97011214
122MP0008438_abnormal_cutaneous_collagen0.96709936
123MP0002066_abnormal_motor_capabilities/c0.96619949
124MP0010352_gastrointestinal_tract_polyps0.96603718
125MP0000604_amyloidosis0.96343692
126MP0005164_abnormal_response_to0.96222387
127MP0005408_hypopigmentation0.93915848
128MP0001970_abnormal_pain_threshold0.92794367
129MP0002572_abnormal_emotion/affect_behav0.91710533
130MP0003646_muscle_fatigue0.91280799
131MP0002067_abnormal_sensory_capabilities0.91088118
132MP0000026_abnormal_inner_ear0.90112019
133MP0009763_increased_sensitivity_to0.88232907
134MP0005390_skeleton_phenotype0.87878254
135MP0000747_muscle_weakness0.86103586
136MP0002138_abnormal_hepatobiliary_system0.85483869
137MP0001340_abnormal_eyelid_morphology0.84996994
138MP0004924_abnormal_behavior0.84501006
139MP0005386_behavior/neurological_phenoty0.84501006
140MP0005195_abnormal_posterior_eye0.83444881
141MP0000372_irregular_coat_pigmentation0.83357091
142MP0002733_abnormal_thermal_nociception0.81595350
143MP0009765_abnormal_xenobiotic_induced0.80768807
144MP0005257_abnormal_intraocular_pressure0.79669312
145MP0004185_abnormal_adipocyte_glucose0.79462224
146MP0003195_calcinosis0.78192342
147MP0000427_abnormal_hair_cycle0.78024847
148MP0005666_abnormal_adipose_tissue0.77871635
149MP0003633_abnormal_nervous_system0.77761038
150MP0005623_abnormal_meninges_morphology0.77291767
151MP0009250_abnormal_appendicular_skeleto0.76971314
152MP0002295_abnormal_pulmonary_circulatio0.75836357
153MP0002063_abnormal_learning/memory/cond0.75455328
154MP0001661_extended_life_span0.75449015
155MP0005647_abnormal_sex_gland0.74891595
156MP0001216_abnormal_epidermal_layer0.73607007
157MP0001191_abnormal_skin_condition0.73422573
158MP0001663_abnormal_digestive_system0.73020100
159MP0003763_abnormal_thymus_physiology0.72109633
160MP0002398_abnormal_bone_marrow0.72088883
161MP0005464_abnormal_platelet_physiology0.71237400
162MP0001188_hyperpigmentation0.70059533
163MP0001177_atelectasis0.69448682
164MP0003705_abnormal_hypodermis_morpholog0.67874731
165MP0002429_abnormal_blood_cell0.67299206
166MP0001348_abnormal_lacrimal_gland0.66490480
167MP0005535_abnormal_body_temperature0.65318186
168MP0005076_abnormal_cell_differentiation0.64128046
169MP0008874_decreased_physiological_sensi0.63792843
170MP0004272_abnormal_basement_membrane0.63638044
171MP0005253_abnormal_eye_physiology0.63425439
172MP0002735_abnormal_chemical_nociception0.63405824
173MP0006072_abnormal_retinal_apoptosis0.62639566
174MP0010234_abnormal_vibrissa_follicle0.62272341
175MP0001727_abnormal_embryo_implantation0.60324523
176MP0006082_CNS_inflammation0.60170326
177MP0005266_abnormal_metabolism0.59485636
178MP0002938_white_spotting0.57990536
179MP0002152_abnormal_brain_morphology0.57544396
180MP0002722_abnormal_immune_system0.56813776
181MP0000689_abnormal_spleen_morphology0.56691480
182MP0004883_abnormal_blood_vessel0.55939372
183MP0010307_abnormal_tumor_latency0.55394869
184MP0001243_abnormal_dermal_layer0.54885417

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.91935130
2Abnormality of liposaccharide metabolism (HP:0010968)6.91935130
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.91935130
4Degeneration of the lateral corticospinal tracts (HP:0002314)6.61150009
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.61150009
6Neurofibrillary tangles (HP:0002185)5.63360772
7Retrobulbar optic neuritis (HP:0100654)5.38372306
8Optic neuritis (HP:0100653)5.38372306
9Sensory axonal neuropathy (HP:0003390)5.35858977
10Orchitis (HP:0100796)5.21754443
11Abnormality of the corticospinal tract (HP:0002492)4.76429858
12Disinhibition (HP:0000734)4.47192279
13Systemic lupus erythematosus (HP:0002725)4.43416178
14Myositis (HP:0100614)4.37034324
15Loss of speech (HP:0002371)4.35652600
16Peripheral hypomyelination (HP:0007182)4.25050574
17Keratoconjunctivitis sicca (HP:0001097)4.23746976
18Stomatitis (HP:0010280)4.23595610
19Vacuolated lymphocytes (HP:0001922)4.23535225
20Abnormality of nail color (HP:0100643)4.20866806
21* Parakeratosis (HP:0001036)4.13354744
22Increased IgE level (HP:0003212)4.09878728
23Increased cerebral lipofuscin (HP:0011813)4.06984308
24Dysostosis multiplex (HP:0000943)4.06805285
25* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.98909550
26Recurrent bacterial skin infections (HP:0005406)3.89251439
27Abnormality of macrophages (HP:0004311)3.88278162
28Cerebral inclusion bodies (HP:0100314)3.87709966
29Keratoconjunctivitis (HP:0001096)3.85412919
30Nuclear cataract (HP:0100018)3.82493264
31Autoimmune thrombocytopenia (HP:0001973)3.77882824
32Onion bulb formation (HP:0003383)3.72582948
33Mutism (HP:0002300)3.66448848
34Cerebral hypomyelination (HP:0006808)3.62092866
35* Congenital ichthyosiform erythroderma (HP:0007431)3.51904224
36Akinesia (HP:0002304)3.46008410
37Spastic gait (HP:0002064)3.39012443
38Hypoplastic pelvis (HP:0008839)3.38426907
39Axonal loss (HP:0003447)3.36331095
40Eczematoid dermatitis (HP:0000976)3.35888476
41Thick nail (HP:0001805)3.31175011
42Supranuclear gaze palsy (HP:0000605)3.28321819
43* Gangrene (HP:0100758)3.21096054
44Abnormal auditory evoked potentials (HP:0006958)3.18344004
45Termporal pattern (HP:0011008)3.16579879
46Insidious onset (HP:0003587)3.16579879
47Alacrima (HP:0000522)3.15272019
48Palmoplantar hyperkeratosis (HP:0000972)3.14766375
49Increased neuronal autofluorescent lipopigment (HP:0002074)3.09896961
50Interstitial pulmonary disease (HP:0006530)3.09648622
51Slow saccadic eye movements (HP:0000514)3.08123144
52Intention tremor (HP:0002080)3.06576646
53Apathy (HP:0000741)3.01153255
54Abnormality of polysaccharide metabolism (HP:0011012)2.99258635
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99258635
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99258635
57Mediastinal lymphadenopathy (HP:0100721)2.95029052
58Palmar hyperkeratosis (HP:0010765)2.90410763
59Recurrent abscess formation (HP:0002722)2.87197842
60Thickened helices (HP:0000391)2.84808665
61Diminished motivation (HP:0000745)2.84074425
62Plantar hyperkeratosis (HP:0007556)2.82294747
63White forelock (HP:0002211)2.82196367
64Glomerulonephritis (HP:0000099)2.80657191
65Urinary glycosaminoglycan excretion (HP:0003541)2.77928047
66Mucopolysacchariduria (HP:0008155)2.77928047
67Increased IgM level (HP:0003496)2.77250238
68Dysmetria (HP:0001310)2.76192562
69Patchy hypopigmentation of hair (HP:0011365)2.74242353
70Leukodystrophy (HP:0002415)2.71514823
71Absent septum pellucidum (HP:0001331)2.71066380
72Spastic paraparesis (HP:0002313)2.70092462
73Increased serum pyruvate (HP:0003542)2.69078472
74Abnormality of glycolysis (HP:0004366)2.69078472
75Pulmonary infiltrates (HP:0002113)2.68644981
76Alopecia of scalp (HP:0002293)2.66630966
77Hypergammaglobulinemia (HP:0010702)2.66064594
78Decreased lacrimation (HP:0000633)2.62342617
79Oral leukoplakia (HP:0002745)2.60650408
80Autoamputation (HP:0001218)2.58140080
81Premature skin wrinkling (HP:0100678)2.54263427
82Increased serum ferritin (HP:0003281)2.50386014
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49507744
84Inappropriate behavior (HP:0000719)2.48207431
85Vasculitis (HP:0002633)2.45091098
86Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43985979
87Stridor (HP:0010307)2.43788726
88Onycholysis (HP:0001806)2.41328540
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39454055
90Hypoplasia of the iris (HP:0007676)2.36843365
91Anteriorly placed anus (HP:0001545)2.36229111
92Hematochezia (HP:0002573)2.35591894
93Cupped ear (HP:0000378)2.34184287
94Retinal dysplasia (HP:0007973)2.33905748
95Neuronal loss in central nervous system (HP:0002529)2.33811939
96Amyloidosis (HP:0011034)2.33416762
97Progressive neurologic deterioration (HP:0002344)2.33197295
98Abnormality of the septum pellucidum (HP:0007375)2.31712134
99Scanning speech (HP:0002168)2.31355743
100Polyneuropathy (HP:0001271)2.28804862
101Basal ganglia calcification (HP:0002135)2.28401680
102Coronal craniosynostosis (HP:0004440)2.28101462
103Abnormal blistering of the skin (HP:0008066)2.28094038
104Ankle clonus (HP:0011448)2.26764462
105Metaphyseal irregularity (HP:0003025)2.25162757
106Split foot (HP:0001839)2.23226316
107Septo-optic dysplasia (HP:0100842)2.23172755
108Erythema (HP:0010783)2.23113155
109Aplasia involving bones of the upper limbs (HP:0009823)2.21315988
110Aplasia of the phalanges of the hand (HP:0009802)2.21315988
111Aplasia involving bones of the extremities (HP:0009825)2.21315988
112Methylmalonic acidemia (HP:0002912)2.21254849
113Agnosia (HP:0010524)2.19994153
114Adrenal hypoplasia (HP:0000835)2.19806343
115Hyporeflexia of lower limbs (HP:0002600)2.18259199
116CNS hypomyelination (HP:0003429)2.17442565
117Complement deficiency (HP:0004431)2.17419873
118Hemoptysis (HP:0002105)2.17070147
119Esophageal atresia (HP:0002032)2.16725398
120Nausea (HP:0002018)2.16245081
121Autoimmune hemolytic anemia (HP:0001890)2.14443597
122Increased circulating renin level (HP:0000848)2.14129986
123Segmental peripheral demyelination/remyelination (HP:0003481)2.13312919
124Duplicated collecting system (HP:0000081)2.11989157
125Morphological abnormality of the inner ear (HP:0011390)2.11331656
126Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10806413
127Hypophosphatemic rickets (HP:0004912)2.10026856
128Elevated erythrocyte sedimentation rate (HP:0003565)2.09835308
129Purpura (HP:0000979)2.09074568
130Arterial thrombosis (HP:0004420)2.08570305
131Myelomeningocele (HP:0002475)2.06584002
132Hypomagnesemia (HP:0002917)2.05211329
133Hypotrichosis (HP:0001006)2.02560746
134Personality changes (HP:0000751)2.02373895
135Memory impairment (HP:0002354)2.01814029
136Hepatosplenomegaly (HP:0001433)1.99722401
137Humeroradial synostosis (HP:0003041)1.99354724
138Synostosis involving the elbow (HP:0003938)1.99354724
139Partial agenesis of the corpus callosum (HP:0001338)1.99224404
140Barrel-shaped chest (HP:0001552)1.98604499
141Keratitis (HP:0000491)1.98143731
142Clumsiness (HP:0002312)1.98130116
143Myokymia (HP:0002411)1.97744291
144Urticaria (HP:0001025)1.96732240
145Malnutrition (HP:0004395)1.96376888
146Dementia (HP:0000726)1.96371309
147Steppage gait (HP:0003376)1.96217355
148Cerebral hemorrhage (HP:0001342)1.95484097
149Anorexia (HP:0002039)1.95179520
150Abnormality of the pericardium (HP:0001697)1.94735103
151Vertigo (HP:0002321)1.94082155
152Anomalous pulmonary venous return (HP:0010772)1.93315438
153Foot dorsiflexor weakness (HP:0009027)1.93187609
154Myocardial infarction (HP:0001658)1.92433173
155Recurrent skin infections (HP:0001581)1.91688567
156Joint swelling (HP:0001386)1.91490959
157Recurrent viral infections (HP:0004429)1.90870657
158Diminished movement (HP:0002374)1.90418765
159Nail dystrophy (HP:0008404)1.90117928
160Recurrent gram-negative bacterial infections (HP:0005420)1.89820418
161Acne (HP:0001061)1.89124343
162Conical tooth (HP:0000698)1.89049977
163Thin bony cortex (HP:0002753)1.88584490
164Abnormality of the pleura (HP:0002103)1.88255456
165Hyperparathyroidism (HP:0000843)1.88151679
166Abnormality of iron homeostasis (HP:0011031)1.87884431
167Partial duplication of thumb phalanx (HP:0009944)1.86673681
168Prolonged neonatal jaundice (HP:0006579)1.85829891
169Metabolic alkalosis (HP:0200114)1.85471327
170Decreased motor nerve conduction velocity (HP:0003431)1.84459036
171Muscle fiber splitting (HP:0003555)1.83879470
172Xerostomia (HP:0000217)1.83756102
173T lymphocytopenia (HP:0005403)1.83474440
174* Erythroderma (HP:0001019)1.81795721
175Renal Fanconi syndrome (HP:0001994)1.80511850
176Paraparesis (HP:0002385)1.78949281
177Abnormality of the middle phalanges of the toes (HP:0010183)1.78509974
178Lower limb muscle weakness (HP:0007340)1.77989282
179Poor speech (HP:0002465)1.77425254
180Congenital sensorineural hearing impairment (HP:0008527)1.76628223
181Spastic tetraparesis (HP:0001285)1.74738573
182Mixed hearing impairment (HP:0000410)1.74688610
183Dynein arm defect of respiratory motile cilia (HP:0012255)1.73930056
184Absent/shortened dynein arms (HP:0200106)1.73930056
185Abnormality of the salivary glands (HP:0010286)1.73173748
186Abnormality of the foot musculature (HP:0001436)1.72847457
187Infantile muscular hypotonia (HP:0008947)1.71116011
188Abnormality of the renal collecting system (HP:0004742)1.68780502
189Nasolacrimal duct obstruction (HP:0000579)1.68472792
190Chin dimple (HP:0010751)1.67027537
191Urinary incontinence (HP:0000020)1.64273298
192Bowel incontinence (HP:0002607)1.63521324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.31145647
2IRAK35.67808205
3OXSR14.63360000
4NME24.12978979
5RIPK13.55590394
6EPHB13.43526056
7TAOK23.23296935
8TNIK3.17538197
9BCR3.05339719
10TBK12.82675331
11CDK192.76057579
12PBK2.74309462
13PIM22.60412638
14PKN12.56194395
15WNK42.45029925
16MET2.40290161
17MATK2.37039498
18IKBKB2.35153140
19TAOK12.28576278
20MAPKAPK52.28516170
21IRAK42.17393636
22IKBKE2.16621006
23MAP3K112.10134731
24MAP3K32.06746927
25WNK11.91764896
26CASK1.89892785
27FGFR21.89790391
28MST41.85684714
29LIMK11.78278752
30TYK21.76044050
31TXK1.73149454
32ICK1.68239008
33NEK61.67933207
34TGFBR21.66704470
35CSNK1G31.62448614
36MAP4K11.62215485
37UHMK11.59212947
38CSNK1A1L1.54308849
39RIPK41.51773957
40CHUK1.49968623
41PRPF4B1.48321857
42CDC42BPA1.47065195
43LATS21.41399580
44JAK31.39492907
45ROCK21.36536010
46CAMK2B1.30629698
47FGR1.30097850
48CLK11.28455435
49CSNK1G11.25322554
50ERN11.24555943
51ABL21.21737125
52NTRK11.21380963
53TESK21.19513124
54PNCK1.16885626
55CSNK1G21.16163014
56MAP2K31.15885577
57BLK1.12193719
58PAK61.10185203
59MAP3K131.09425854
60CAMK2D1.05060186
61MAP3K11.03874311
62MAP3K50.99259177
63BMPR1B0.94967131
64EPHA40.93215140
65JAK10.93052512
66MARK20.92654540
67MAPK150.91987123
68DYRK20.90711852
69PAK30.90479567
70PRKCQ0.89652017
71STK100.88643256
72SGK4940.87145487
73SGK2230.87145487
74PDGFRA0.85311130
75ARAF0.81799625
76DYRK30.81439188
77ACVR1B0.80644568
78ZAP700.80513338
79CAMK2G0.79317190
80MAP2K60.79277153
81ERBB40.78271078
82JAK20.75334694
83LYN0.74763140
84MARK10.73386593
85SYK0.70769852
86PRKCE0.70396742
87PIM10.69777577
88TYRO30.69046643
89BMX0.68262506
90CDK140.68235434
91CAMK2A0.68131745
92TRPM70.66408933
93CDK50.66239560
94MKNK10.65412533
95STK240.64546538
96RPS6KA50.62614511
97PHKG20.62531708
98PHKG10.62531708
99PRKD10.62017004
100IRAK20.56991434
101CDK150.56453863
102STK160.56059297
103GRK10.55212867
104MUSK0.55056330
105CSF1R0.54881655
106FYN0.54826548
107HIPK20.53520139
108LCK0.52637247
109CDK180.52588089
110MAPK40.51202853
111CDK11A0.50325664
112CSNK1D0.49355858
113MARK30.48809863
114PDPK10.47553357
115CDK60.46639886
116ADRBK20.46017286
117PRKG10.45427300
118TESK10.45410698
119TGFBR10.43306956
120DDR20.42743811
121IRAK10.41135298
122GSK3A0.40965270
123DAPK30.39884596
124HCK0.39397792
125DMPK0.39273887
126BMPR20.39164465
127OBSCN0.38719696
128NTRK20.38297442
129GRK70.38020364
130SIK30.37988693
131EPHB20.37555489
132STK110.37205590
133MAPK130.34799933
134SIK10.34587659
135CSNK1A10.34139494
136PAK10.33784354
137EPHA30.33614080
138MAP3K20.33600681
139MST1R0.33380702
140BTK0.33373571
141MAP3K90.33226746
142PRKACB0.32455964
143MAPK70.31401398
144PDGFRB0.31324919
145CDK30.30355495
146EGFR0.30216560
147INSR0.29730646
148ROCK10.27737277
149PIK3CA0.26536996
150RPS6KC10.26456930
151RPS6KL10.26456930
152MAP3K140.25545784
153ABL10.25372684
154PRKACA0.25367740
155PRKD20.25325746
156FER0.25106795
157ITK0.24749256
158PAK40.24620110
159EIF2AK20.24262740
160PIK3CG0.23497748
161MOS0.23076983
162DAPK20.22105770
163CSK0.22010059
164CAMK1G0.21760476
165MAPKAPK20.21722109
166RPS6KA60.20132574
167DYRK1B0.18224602
168PRKCD0.14673608
169SIK20.12756320
170PRKAA20.11165690
171BRAF0.10880340

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.46167373
2Steroid biosynthesis_Homo sapiens_hsa001005.09253120
3Fatty acid elongation_Homo sapiens_hsa000624.59899053
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.34283366
5Ether lipid metabolism_Homo sapiens_hsa005653.20694968
6Toll-like receptor signaling pathway_Homo sapiens_hsa046203.15194709
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.86240295
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85326865
9Asthma_Homo sapiens_hsa053102.70842516
10Allograft rejection_Homo sapiens_hsa053302.66755731
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.61337101
12Other glycan degradation_Homo sapiens_hsa005112.56806634
13Osteoclast differentiation_Homo sapiens_hsa043802.55401903
14TNF signaling pathway_Homo sapiens_hsa046682.53490293
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42625201
16Staphylococcus aureus infection_Homo sapiens_hsa051502.37308266
17Leishmaniasis_Homo sapiens_hsa051402.32853679
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31502281
19Pertussis_Homo sapiens_hsa051332.31301661
20African trypanosomiasis_Homo sapiens_hsa051432.28059868
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23095151
22Sphingolipid metabolism_Homo sapiens_hsa006002.22760112
23Intestinal immune network for IgA production_Homo sapiens_hsa046722.15709369
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12090388
25Axon guidance_Homo sapiens_hsa043602.03236039
26Linoleic acid metabolism_Homo sapiens_hsa005912.00028315
27Legionellosis_Homo sapiens_hsa051341.99994423
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99939944
29Oxidative phosphorylation_Homo sapiens_hsa001901.97980434
30Tuberculosis_Homo sapiens_hsa051521.94065218
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.88370743
32Protein export_Homo sapiens_hsa030601.85506574
33Sulfur metabolism_Homo sapiens_hsa009201.84515291
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81920035
35Influenza A_Homo sapiens_hsa051641.79341735
36Histidine metabolism_Homo sapiens_hsa003401.74247009
37Toxoplasmosis_Homo sapiens_hsa051451.68840471
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59565104
39Type I diabetes mellitus_Homo sapiens_hsa049401.54494833
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54206475
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.48355746
42Serotonergic synapse_Homo sapiens_hsa047261.39423587
43Prion diseases_Homo sapiens_hsa050201.39065057
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.36618212
45Hepatitis C_Homo sapiens_hsa051601.32278239
46Measles_Homo sapiens_hsa051621.31840211
47Arachidonic acid metabolism_Homo sapiens_hsa005901.31341498
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30085425
49Hematopoietic cell lineage_Homo sapiens_hsa046401.27805260
50Herpes simplex infection_Homo sapiens_hsa051681.27275347
51Alzheimers disease_Homo sapiens_hsa050101.25797285
52Parkinsons disease_Homo sapiens_hsa050121.22907300
53Amoebiasis_Homo sapiens_hsa051461.16132026
54Butanoate metabolism_Homo sapiens_hsa006501.14747831
55Antigen processing and presentation_Homo sapiens_hsa046121.13373790
56Autoimmune thyroid disease_Homo sapiens_hsa053201.13134142
57Vitamin B6 metabolism_Homo sapiens_hsa007501.10111478
58Arginine and proline metabolism_Homo sapiens_hsa003301.06515660
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04948870
60Tight junction_Homo sapiens_hsa045301.04741778
61Viral myocarditis_Homo sapiens_hsa054161.03806166
62Shigellosis_Homo sapiens_hsa051311.03505441
63Long-term depression_Homo sapiens_hsa047301.02444679
64Glutamatergic synapse_Homo sapiens_hsa047241.01597381
65Bladder cancer_Homo sapiens_hsa052190.99956406
66Renal cell carcinoma_Homo sapiens_hsa052110.99891656
67Hepatitis B_Homo sapiens_hsa051610.98199573
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.96742749
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96646004
70Chemokine signaling pathway_Homo sapiens_hsa040620.95268275
71Vibrio cholerae infection_Homo sapiens_hsa051100.93737553
72Rheumatoid arthritis_Homo sapiens_hsa053230.93540975
73Collecting duct acid secretion_Homo sapiens_hsa049660.93063279
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92341033
75B cell receptor signaling pathway_Homo sapiens_hsa046620.91141623
76Apoptosis_Homo sapiens_hsa042100.89982047
77Phototransduction_Homo sapiens_hsa047440.89195383
78VEGF signaling pathway_Homo sapiens_hsa043700.88018751
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87878078
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87279682
81GABAergic synapse_Homo sapiens_hsa047270.86120595
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.85687457
83Ovarian steroidogenesis_Homo sapiens_hsa049130.84140975
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84126727
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82134024
86Acute myeloid leukemia_Homo sapiens_hsa052210.81201941
87Prolactin signaling pathway_Homo sapiens_hsa049170.80768079
88Ras signaling pathway_Homo sapiens_hsa040140.80628777
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78929069
90T cell receptor signaling pathway_Homo sapiens_hsa046600.78401942
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77689664
92Glutathione metabolism_Homo sapiens_hsa004800.77470211
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.74249734
94Epstein-Barr virus infection_Homo sapiens_hsa051690.74215309
95Morphine addiction_Homo sapiens_hsa050320.74022382
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73550098
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.71963472
98Endocytosis_Homo sapiens_hsa041440.71717524
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69248805
100ECM-receptor interaction_Homo sapiens_hsa045120.69176237
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68200168
102Hedgehog signaling pathway_Homo sapiens_hsa043400.67807284
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67787415
104Malaria_Homo sapiens_hsa051440.67464169
105Type II diabetes mellitus_Homo sapiens_hsa049300.67405239
106Primary immunodeficiency_Homo sapiens_hsa053400.64686006
107ErbB signaling pathway_Homo sapiens_hsa040120.63415734
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.62081188
109Phagosome_Homo sapiens_hsa041450.61655494
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.58670541
111Fatty acid metabolism_Homo sapiens_hsa012120.58172827
112Complement and coagulation cascades_Homo sapiens_hsa046100.56796385
113Retinol metabolism_Homo sapiens_hsa008300.55987686
114Cardiac muscle contraction_Homo sapiens_hsa042600.54422508
115Lysosome_Homo sapiens_hsa041420.53170724
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52839984
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52730005
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51756789
119Huntingtons disease_Homo sapiens_hsa050160.51694504
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51113316
121Cocaine addiction_Homo sapiens_hsa050300.50228323
122Mineral absorption_Homo sapiens_hsa049780.47597937
123Vitamin digestion and absorption_Homo sapiens_hsa049770.47129640
124Dorso-ventral axis formation_Homo sapiens_hsa043200.45842260
125Fatty acid biosynthesis_Homo sapiens_hsa000610.45173024
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44953418
127Tyrosine metabolism_Homo sapiens_hsa003500.44696615
128Salivary secretion_Homo sapiens_hsa049700.44473497
129Circadian entrainment_Homo sapiens_hsa047130.42684704
130Pancreatic secretion_Homo sapiens_hsa049720.42056266
131HTLV-I infection_Homo sapiens_hsa051660.40866777
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40669694
133Metabolic pathways_Homo sapiens_hsa011000.40296475
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39681199
135Propanoate metabolism_Homo sapiens_hsa006400.39610337
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.39356173
137Basal cell carcinoma_Homo sapiens_hsa052170.38208533
138Peroxisome_Homo sapiens_hsa041460.38174395
139Notch signaling pathway_Homo sapiens_hsa043300.38119932
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37857558
141Nicotine addiction_Homo sapiens_hsa050330.37014031
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35380432
143Dopaminergic synapse_Homo sapiens_hsa047280.34972760
144Gastric acid secretion_Homo sapiens_hsa049710.33598426
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32994000
146Chemical carcinogenesis_Homo sapiens_hsa052040.32581886
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31487716
148Cholinergic synapse_Homo sapiens_hsa047250.31118798
149Graft-versus-host disease_Homo sapiens_hsa053320.30870167
150Wnt signaling pathway_Homo sapiens_hsa043100.29795563
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29251908
152Choline metabolism in cancer_Homo sapiens_hsa052310.29090754
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28486397
154Taste transduction_Homo sapiens_hsa047420.28326369
155MAPK signaling pathway_Homo sapiens_hsa040100.28100383
156Insulin resistance_Homo sapiens_hsa049310.27963598
157Salmonella infection_Homo sapiens_hsa051320.27899895
158HIF-1 signaling pathway_Homo sapiens_hsa040660.27452014
159Renin secretion_Homo sapiens_hsa049240.27278296
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27189386
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26669771
162Systemic lupus erythematosus_Homo sapiens_hsa053220.25928515
163ABC transporters_Homo sapiens_hsa020100.25813198
164Galactose metabolism_Homo sapiens_hsa000520.25548495
165Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25317462
166GnRH signaling pathway_Homo sapiens_hsa049120.24985109
167Chronic myeloid leukemia_Homo sapiens_hsa052200.23484976
168Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23420010
169Small cell lung cancer_Homo sapiens_hsa052220.22928243
170FoxO signaling pathway_Homo sapiens_hsa040680.22801039
171Viral carcinogenesis_Homo sapiens_hsa052030.21935510
172PPAR signaling pathway_Homo sapiens_hsa033200.21854944
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.18554878
174Tryptophan metabolism_Homo sapiens_hsa003800.17082927

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »