NIPAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.66779572
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.29448323
3GDP-mannose metabolic process (GO:0019673)5.89296312
4establishment of skin barrier (GO:0061436)5.71672073
5signal peptide processing (GO:0006465)5.69659712
6hemidesmosome assembly (GO:0031581)5.42907870
7regulation of water loss via skin (GO:0033561)5.12065975
8keratinocyte development (GO:0003334)5.06455617
9positive regulation of cellular amine metabolic process (GO:0033240)4.98225370
10intestinal epithelial cell development (GO:0060576)4.97388180
11keratinization (GO:0031424)4.89373358
12DNA deamination (GO:0045006)4.82535250
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.68694223
14regulation of type B pancreatic cell apoptotic process (GO:2000674)4.64238751
15cotranslational protein targeting to membrane (GO:0006613)4.59824479
16protein targeting to ER (GO:0045047)4.58222047
17regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.57722231
18keratinocyte proliferation (GO:0043616)4.55359918
19dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.55057386
20respiratory chain complex IV assembly (GO:0008535)4.46691100
21protein localization to endoplasmic reticulum (GO:0070972)4.38559336
22negative regulation of metanephros development (GO:0072217)4.37333057
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.35786944
24cellular glucuronidation (GO:0052695)4.35779009
25negative regulation of keratinocyte proliferation (GO:0010839)4.30409703
26glucuronate metabolic process (GO:0019585)4.27588980
27uronic acid metabolic process (GO:0006063)4.27588980
28mannosylation (GO:0097502)4.24030573
29flavonoid metabolic process (GO:0009812)4.01565933
30ribosomal small subunit assembly (GO:0000028)3.94027670
31regulation of apoptotic process involved in morphogenesis (GO:1902337)3.88758193
32drug catabolic process (GO:0042737)3.87784754
33regulation of keratinocyte proliferation (GO:0010837)3.87619002
34exogenous drug catabolic process (GO:0042738)3.86832647
35negative regulation of transcription by competitive promoter binding (GO:0010944)3.86640175
36viral transcription (GO:0019083)3.86275931
37glandular epithelial cell differentiation (GO:0002067)3.85801077
38cellular ketone body metabolic process (GO:0046950)3.85427091
39nephron tubule formation (GO:0072079)3.84816758
40endocrine pancreas development (GO:0031018)3.84230528
41ribosomal small subunit biogenesis (GO:0042274)3.82594445
42GPI anchor biosynthetic process (GO:0006506)3.78117135
43translational termination (GO:0006415)3.70375151
44multicellular organismal water homeostasis (GO:0050891)3.68131859
45proteasome assembly (GO:0043248)3.64195526
46hair cycle (GO:0042633)3.60808979
47molting cycle (GO:0042303)3.60808979
48gap junction assembly (GO:0016264)3.50887204
49epoxygenase P450 pathway (GO:0019373)3.48290270
50positive regulation of hormone metabolic process (GO:0032352)3.47167923
51termination of RNA polymerase III transcription (GO:0006386)3.45525210
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.45525210
53ketone body metabolic process (GO:1902224)3.45501452
54cytochrome complex assembly (GO:0017004)3.43346677
55C-terminal protein lipidation (GO:0006501)3.43326734
56GMP metabolic process (GO:0046037)3.41765523
57pattern specification involved in kidney development (GO:0061004)3.41716336
58postsynaptic membrane organization (GO:0001941)3.39569808
59drug transmembrane transport (GO:0006855)3.33827411
60negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.32014831
61keratinocyte differentiation (GO:0030216)3.28519535
62water-soluble vitamin biosynthetic process (GO:0042364)3.28121531
63mesonephros development (GO:0001823)3.26794341
64phenylpropanoid metabolic process (GO:0009698)3.26236488
65GPI anchor metabolic process (GO:0006505)3.25157323
66water homeostasis (GO:0030104)3.24564655
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.21984596
68phosphatidylinositol acyl-chain remodeling (GO:0036149)3.18735909
69intermediate filament organization (GO:0045109)3.17457708
70presynaptic membrane assembly (GO:0097105)3.17102592
71phosphatidylserine acyl-chain remodeling (GO:0036150)3.14507115
72peptidyl-threonine dephosphorylation (GO:0035970)3.11587978
73androgen biosynthetic process (GO:0006702)3.11471787
74regulation of hippo signaling (GO:0035330)3.10559218
75ribosomal large subunit biogenesis (GO:0042273)3.09519986
76mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.08342389
77indole-containing compound catabolic process (GO:0042436)3.08316770
78indolalkylamine catabolic process (GO:0046218)3.08316770
79tryptophan catabolic process (GO:0006569)3.08316770
80nucleotide-sugar metabolic process (GO:0009225)3.07273654
81protein heterotetramerization (GO:0051290)3.06645318
82bile acid and bile salt transport (GO:0015721)3.06147357
83kynurenine metabolic process (GO:0070189)3.06115274
84drug metabolic process (GO:0017144)3.04889732
85lymphoid progenitor cell differentiation (GO:0002320)3.00605444
86L-methionine salvage (GO:0071267)2.94158651
87L-methionine biosynthetic process (GO:0071265)2.94158651
88amino acid salvage (GO:0043102)2.94158651
89intestinal absorption (GO:0050892)2.92726976
90nucleotide transmembrane transport (GO:1901679)2.92514183
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.92287175
92amino sugar catabolic process (GO:0046348)2.90901896
93positive regulation of gluconeogenesis (GO:0045722)2.90386816
94regulation of pigment cell differentiation (GO:0050932)2.89049785
95purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87986732
963-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87986732
97S-adenosylmethionine metabolic process (GO:0046500)2.87440915
98sphingoid metabolic process (GO:0046519)2.86501447
99maturation of SSU-rRNA (GO:0030490)2.86160201
100phospholipid scrambling (GO:0017121)2.85211488
101oxidative demethylation (GO:0070989)2.84731455
102indolalkylamine metabolic process (GO:0006586)2.84179273
103translational elongation (GO:0006414)2.84082316
104protein targeting to membrane (GO:0006612)2.83966652
105sphingosine metabolic process (GO:0006670)2.82720972
106positive regulation of glycoprotein biosynthetic process (GO:0010560)2.82664813
107metanephric nephron tubule development (GO:0072234)2.81890478
108metanephric tubule development (GO:0072170)2.81890478
109regulation of metalloenzyme activity (GO:0048552)2.81064481
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80939823
111viral life cycle (GO:0019058)2.80184977
112peptide hormone processing (GO:0016486)2.79280676
113negative regulation of execution phase of apoptosis (GO:1900118)2.77400533
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76266587
115mesenchymal to epithelial transition (GO:0060231)2.75270064
116peptidyl-histidine modification (GO:0018202)2.74005347
117translation (GO:0006412)2.73351852
118diol metabolic process (GO:0034311)2.72733352
119polarized epithelial cell differentiation (GO:0030859)2.71601276
120tryptophan metabolic process (GO:0006568)2.68052777
121response to pheromone (GO:0019236)2.66972791
122aromatic amino acid family catabolic process (GO:0009074)2.66727134
123arginine metabolic process (GO:0006525)2.66582999
124epidermal cell differentiation (GO:0009913)2.66503859
125facial nerve structural organization (GO:0021612)2.66424348
126epidermis development (GO:0008544)2.65397123
127regulation of mesenchymal cell apoptotic process (GO:2001053)2.64476023
128C-terminal protein amino acid modification (GO:0018410)2.63505906
129tRNA methylation (GO:0030488)2.62848562
130organic cation transport (GO:0015695)2.62827822
131negative regulation of kidney development (GO:0090185)2.62647596
132guanosine-containing compound biosynthetic process (GO:1901070)2.62571867
133phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.61638260
134heme transport (GO:0015886)2.60694148
135N-acetylneuraminate metabolic process (GO:0006054)2.60680101
136bile acid metabolic process (GO:0008206)2.60341268
137translational initiation (GO:0006413)2.59951910
138cellular protein complex disassembly (GO:0043624)2.59941953
139phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.59357078
140GTP biosynthetic process (GO:0006183)2.58272357
141urogenital system development (GO:0001655)2.58162874
142glucosamine-containing compound catabolic process (GO:1901072)2.57184466
143L-fucose catabolic process (GO:0042355)2.53952319
144fucose catabolic process (GO:0019317)2.53952319
145L-fucose metabolic process (GO:0042354)2.53952319
146mature B cell differentiation involved in immune response (GO:0002313)2.53527584
147preassembly of GPI anchor in ER membrane (GO:0016254)2.52650641
148sulfate transmembrane transport (GO:1902358)2.52405840
149urate metabolic process (GO:0046415)2.52283998
150platelet dense granule organization (GO:0060155)2.52014661
151pyrimidine-containing compound transmembrane transport (GO:0072531)2.52002031
152generation of neurons (GO:0048699)2.51752636
153negative regulation of glycoprotein biosynthetic process (GO:0010561)2.50393190
154vitamin biosynthetic process (GO:0009110)2.47885240
155sequestering of metal ion (GO:0051238)2.47617426
156mature B cell differentiation (GO:0002335)2.45197727
157embryonic epithelial tube formation (GO:0001838)2.45053854
158pseudouridine synthesis (GO:0001522)2.44174772
159regulation of hexokinase activity (GO:1903299)2.43698998
160regulation of glucokinase activity (GO:0033131)2.43698998
161quinone biosynthetic process (GO:1901663)2.43631650
162presynaptic membrane organization (GO:0097090)2.43587470
163omega-hydroxylase P450 pathway (GO:0097267)2.43468294
164methionine biosynthetic process (GO:0009086)2.42826979
165regulation of guanylate cyclase activity (GO:0031282)2.42749291
166negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.42078462
167intestinal cholesterol absorption (GO:0030299)2.41735872
168kidney morphogenesis (GO:0060993)2.40376458
169transcytosis (GO:0045056)2.39616852
170sphingomyelin metabolic process (GO:0006684)2.39452260
171genitalia morphogenesis (GO:0035112)2.39451570
172UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39449074
173protein maturation by protein folding (GO:0022417)2.39315103
174positive regulation of insulin secretion (GO:0032024)2.39261255
175developmental pigmentation (GO:0048066)2.39094855
176retinol metabolic process (GO:0042572)2.39037238
177phosphatidylcholine acyl-chain remodeling (GO:0036151)2.38712802
178nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.38267794
179protein K11-linked deubiquitination (GO:0035871)2.37696878
180regulation of hormone metabolic process (GO:0032350)2.37513339
181calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37423038
182alkaloid metabolic process (GO:0009820)2.37098452
183bile acid biosynthetic process (GO:0006699)2.36372869
184glycerol metabolic process (GO:0006071)2.35408876
185amino-acid betaine metabolic process (GO:0006577)2.31744633
186drug transport (GO:0015893)2.31594427
187primary alcohol metabolic process (GO:0034308)2.30882272
188regulation of triglyceride catabolic process (GO:0010896)2.30528062
189ectoderm development (GO:0007398)2.29864608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.83000548
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48644160
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.32284741
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78393682
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.56261741
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42757191
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11717199
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04528291
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.80945733
10ZNF274_21170338_ChIP-Seq_K562_Hela2.79759315
11VDR_22108803_ChIP-Seq_LS180_Human2.78087621
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.69841259
13EZH2_22144423_ChIP-Seq_EOC_Human2.59753472
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.50562453
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.48269320
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35586370
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31853200
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31041044
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.17842737
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17469386
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15509291
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.13281751
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.12588151
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12033912
25GATA1_22025678_ChIP-Seq_K562_Human2.11817005
26ERG_20887958_ChIP-Seq_HPC-7_Mouse2.10107427
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01046328
28VDR_23849224_ChIP-Seq_CD4+_Human1.98570573
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.97419949
30* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96160229
31IGF1R_20145208_ChIP-Seq_DFB_Human1.95418696
32* GATA4_25053715_ChIP-Seq_YYC3_Human1.88005379
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84356329
34FUS_26573619_Chip-Seq_HEK293_Human1.84325779
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83787696
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82377760
37ER_23166858_ChIP-Seq_MCF-7_Human1.81398665
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.76907515
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.76446477
40* CDX2_22108803_ChIP-Seq_LS180_Human1.74208946
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73563197
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73415430
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73320064
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.71381881
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.69234462
46IRF1_19129219_ChIP-ChIP_H3396_Human1.64135715
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63525409
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59069988
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58924924
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58792190
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57917689
52TP63_23658742_ChIP-Seq_EP156T_Human1.55676561
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54440154
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.53920383
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.53892529
56ELK1_19687146_ChIP-ChIP_HELA_Human1.51236364
57EWS_26573619_Chip-Seq_HEK293_Human1.51119942
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50753920
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50652715
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50628807
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50239875
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47901081
63* P300_19829295_ChIP-Seq_ESCs_Human1.47588382
64GBX2_23144817_ChIP-Seq_PC3_Human1.47231409
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.46035957
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45726814
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44415338
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.43683017
69FOXP3_21729870_ChIP-Seq_TREG_Human1.42255645
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41891572
71TAF15_26573619_Chip-Seq_HEK293_Human1.41193566
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41160320
73TCF4_22108803_ChIP-Seq_LS180_Human1.40423072
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39850892
75SCL_19346495_ChIP-Seq_HPC-7_Human1.39806859
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39127562
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38764076
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38398976
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38298409
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.38298409
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.37342346
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37299420
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36791395
84BCAT_22108803_ChIP-Seq_LS180_Human1.36134133
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35334951
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.34845778
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33823156
88SOX2_20726797_ChIP-Seq_SW620_Human1.32740208
89CJUN_26792858_Chip-Seq_BT549_Human1.32042810
90* GATA6_25053715_ChIP-Seq_YYC3_Human1.31720771
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31297148
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.30914201
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30867327
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30867327
95* CBP_20019798_ChIP-Seq_JUKART_Human1.28456310
96* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28456310
97NANOG_19829295_ChIP-Seq_ESCs_Human1.27381678
98SOX2_19829295_ChIP-Seq_ESCs_Human1.27381678
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27030159
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26997591
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26931662
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26822946
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26584282
104GATA3_24758297_ChIP-Seq_MCF-7_Human1.26502639
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26457896
106SPI1_23547873_ChIP-Seq_NB4_Human1.26276240
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25567444
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.24943521
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24940075
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24843773
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23256560
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.23189574
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23078002
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22949596
115RBPJ_21746931_ChIP-Seq_IB4_Human1.22949512
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22328016
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22176781
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.21826596
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20546299
120AR_25329375_ChIP-Seq_VCAP_Human1.20531196
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19656094
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19020677
123SMAD4_21799915_ChIP-Seq_A2780_Human1.18741711
124DCP1A_22483619_ChIP-Seq_HELA_Human1.18300840
125PHF8_20622853_ChIP-Seq_HELA_Human1.18098779
126* NCOR_22424771_ChIP-Seq_293T_Human1.17999210
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17241084
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16633743
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16428954
130ETV1_20927104_ChIP-Seq_GIST48_Human1.15125788
131ERG_20517297_ChIP-Seq_VCAP_Human1.14904046
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14366871
133PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12543573
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.12375105
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11682273
136HNFA_21074721_ChIP-Seq_CACO-2_Human1.11649893
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11470351
138* GATA3_21867929_ChIP-Seq_CD8_Mouse1.11302454
139HOXB7_26014856_ChIP-Seq_BT474_Human1.11061952
140YY1_21170310_ChIP-Seq_MESCs_Mouse1.10837175
141PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09471198
142AR_20517297_ChIP-Seq_VCAP_Human1.09359087
143LXR_22158963_ChIP-Seq_LIVER_Mouse1.08655618
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08257659
145STAT3_23295773_ChIP-Seq_U87_Human1.07498595
146AHR_22903824_ChIP-Seq_MCF-7_Human1.07352084
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07006244
148HTT_18923047_ChIP-ChIP_STHdh_Human1.06790537
149TCF4_23295773_ChIP-Seq_U87_Human1.06465341
150SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05878562
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05868514
152P53_22387025_ChIP-Seq_ESCs_Mouse1.05747591
153TP53_18474530_ChIP-ChIP_U2OS_Human1.05721723
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.05705399
155CRX_20693478_ChIP-Seq_RETINA_Mouse1.05253579
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05242195
157SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03407910
158P300_18555785_Chip-Seq_ESCs_Mouse1.02821675
159ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02094780
160ZFX_18555785_Chip-Seq_ESCs_Mouse1.01219104
161CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00749678
162ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00737843
163BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00096231
164SOX2_18555785_Chip-Seq_ESCs_Mouse0.99554311
165EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99377827
166KLF4_18555785_Chip-Seq_ESCs_Mouse0.97438449
167OCT4_18555785_Chip-Seq_ESCs_Mouse0.96590622
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95642552
169TTF2_22483619_ChIP-Seq_HELA_Human0.95297821
170MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94589245
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92583731
172* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92483189
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92099333
174GABP_19822575_ChIP-Seq_HepG2_Human0.91908730
175STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91848019
176PU1_27457419_Chip-Seq_LIVER_Mouse0.91382631
177NANOG_18555785_Chip-Seq_ESCs_Mouse0.91193551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.25345155
2MP0009379_abnormal_foot_pigmentation4.80895201
3MP0002796_impaired_skin_barrier4.19814785
4MP0001188_hyperpigmentation3.46184545
5MP0003136_yellow_coat_color3.30071680
6MP0010678_abnormal_skin_adnexa3.29692345
7MP0006292_abnormal_olfactory_placode3.18096017
8MP0005409_darkened_coat_color3.06213374
9MP0004381_abnormal_hair_follicle3.01441369
10MP0005379_endocrine/exocrine_gland_phen2.93642902
11MP0000383_abnormal_hair_follicle2.87802115
12MP0001986_abnormal_taste_sensitivity2.75432131
13MP0005360_urolithiasis2.73841961
14MP0003941_abnormal_skin_development2.67259046
15MP0005174_abnormal_tail_pigmentation2.63910641
16MP0003724_increased_susceptibility_to2.50512482
17MP0002693_abnormal_pancreas_physiology2.49038094
18MP0002876_abnormal_thyroid_physiology2.47311513
19MP0008875_abnormal_xenobiotic_pharmacok2.47130289
20MP0005501_abnormal_skin_physiology2.47006324
21MP0000427_abnormal_hair_cycle2.46425298
22MP0003252_abnormal_bile_duct2.43401186
23MP0000681_abnormal_thyroid_gland2.38895782
24MP0005075_abnormal_melanosome_morpholog2.38405358
25MP0004264_abnormal_extraembryonic_tissu2.29564554
26MP0003868_abnormal_feces_composition2.29348860
27MP0008260_abnormal_autophagy2.26364506
28MP0000015_abnormal_ear_pigmentation2.20926250
29MP0001944_abnormal_pancreas_morphology2.20054290
30MP0000678_abnormal_parathyroid_gland2.14146644
31MP0003183_abnormal_peptide_metabolism2.12145391
32MP0001216_abnormal_epidermal_layer2.09458483
33MP0000467_abnormal_esophagus_morphology2.02589566
34MP0003195_calcinosis2.00756039
35MP0003950_abnormal_plasma_membrane1.93694992
36MP0009697_abnormal_copulation1.89260405
37MP0000647_abnormal_sebaceous_gland1.86097433
38MP0004043_abnormal_pH_regulation1.83221021
39MP0002234_abnormal_pharynx_morphology1.83199166
40MP0000613_abnormal_salivary_gland1.81396547
41MP0002638_abnormal_pupillary_reflex1.72720203
42MP0010771_integument_phenotype1.64419350
43MP0005220_abnormal_exocrine_pancreas1.63173446
44MP0000377_abnormal_hair_follicle1.61274823
45MP0003879_abnormal_hair_cell1.60088337
46MP0002095_abnormal_skin_pigmentation1.60053221
47MP0005275_abnormal_skin_tensile1.59180938
48MP0002163_abnormal_gland_morphology1.58046670
49MP0005671_abnormal_response_to1.57241793
50MP0010329_abnormal_lipoprotein_level1.56759757
51MP0002177_abnormal_outer_ear1.56128485
52MP0000569_abnormal_digit_pigmentation1.53814147
53MP0010352_gastrointestinal_tract_polyps1.52980187
54MP0009780_abnormal_chondrocyte_physiolo1.51785822
55MP0005084_abnormal_gallbladder_morpholo1.49996733
56MP0000372_irregular_coat_pigmentation1.49294864
57MP0005332_abnormal_amino_acid1.48845971
58MP0008872_abnormal_physiological_respon1.48503661
59MP0010386_abnormal_urinary_bladder1.46872517
60MP0009785_altered_susceptibility_to1.45070208
61MP0000490_abnormal_crypts_of1.42144508
62MP0003693_abnormal_embryo_hatching1.40242783
63MP0003718_maternal_effect1.38571276
64MP0002877_abnormal_melanocyte_morpholog1.36419598
65MP0000465_gastrointestinal_hemorrhage1.35849513
66MP0002148_abnormal_hypersensitivity_rea1.33520170
67MP0005636_abnormal_mineral_homeostasis1.32956632
68MP0009333_abnormal_splenocyte_physiolog1.30420786
69MP0005670_abnormal_white_adipose1.30379588
70MP0003763_abnormal_thymus_physiology1.26802302
71MP0002060_abnormal_skin_morphology1.23585683
72MP0003866_abnormal_defecation1.22781476
73MP0002139_abnormal_hepatobiliary_system1.21994612
74MP0005365_abnormal_bile_salt1.20041742
75MP0000049_abnormal_middle_ear1.17853998
76MP0000516_abnormal_urinary_system1.16362175
77MP0005367_renal/urinary_system_phenotyp1.16362175
78MP0002009_preneoplasia1.13551921
79MP0002277_abnormal_respiratory_mucosa1.12030779
80MP0000762_abnormal_tongue_morphology1.11906945
81MP0003453_abnormal_keratinocyte_physiol1.11031434
82MP0000631_abnormal_neuroendocrine_gland1.09843892
83MP0005025_abnormal_response_to1.07993640
84MP0001661_extended_life_span1.07054936
85MP0005000_abnormal_immune_tolerance1.06753710
86MP0003806_abnormal_nucleotide_metabolis1.06409805
87MP0002138_abnormal_hepatobiliary_system1.05921829
88MP0001765_abnormal_ion_homeostasis1.05412176
89MP0001835_abnormal_antigen_presentation1.04570001
90MP0002938_white_spotting1.01933437
91MP0003938_abnormal_ear_development1.01714112
92MP0006072_abnormal_retinal_apoptosis1.01423179
93MP0001919_abnormal_reproductive_system0.99833480
94MP0005083_abnormal_biliary_tract0.99024903
95MP0002837_dystrophic_cardiac_calcinosis0.98901678
96MP0005408_hypopigmentation0.97896698
97MP0003436_decreased_susceptibility_to0.96081941
98MP0000685_abnormal_immune_system0.95450439
99MP0000566_synostosis0.95138790
100MP0005410_abnormal_fertilization0.94939368
101MP0003786_premature_aging0.93492266
102MP0002102_abnormal_ear_morphology0.93474865
103MP0002751_abnormal_autonomic_nervous0.91178789
104MP0002723_abnormal_immune_serum0.90677001
105MP0000462_abnormal_digestive_system0.90275063
106MP0005551_abnormal_eye_electrophysiolog0.89433661
107MP0000367_abnormal_coat/_hair0.89052221
108MP0001666_abnormal_nutrient_absorption0.88655473
109MP0002160_abnormal_reproductive_system0.88343646
110MP0005085_abnormal_gallbladder_physiolo0.88220208
111MP0003315_abnormal_perineum_morphology0.87423936
112MP0003959_abnormal_lean_body0.86819564
113MP0002098_abnormal_vibrissa_morphology0.86471705
114MP0000538_abnormal_urinary_bladder0.86412817
115MP0005395_other_phenotype0.86257046
116MP0001764_abnormal_homeostasis0.85789949
117MP0002419_abnormal_innate_immunity0.85038856
118MP0008469_abnormal_protein_level0.84562460
119MP0004782_abnormal_surfactant_physiolog0.84312829
120MP0002132_abnormal_respiratory_system0.82878343
121MP0010155_abnormal_intestine_physiology0.82786653
122MP0004147_increased_porphyrin_level0.82729780
123MP0004885_abnormal_endolymph0.80848780
124MP0002078_abnormal_glucose_homeostasis0.80485356
125MP0009643_abnormal_urine_homeostasis0.79722682
126MP0001873_stomach_inflammation0.79305034
127MP0001191_abnormal_skin_condition0.79012445
128MP0000579_abnormal_nail_morphology0.77570421
129MP0001845_abnormal_inflammatory_respons0.76776910
130MP0009840_abnormal_foam_cell0.76419654
131MP0005257_abnormal_intraocular_pressure0.74084718
132MP0000627_abnormal_mammary_gland0.73492051
133MP0001664_abnormal_digestion0.73431168
134MP0004957_abnormal_blastocyst_morpholog0.72570622
135MP0005451_abnormal_body_composition0.72180101
136MP0005058_abnormal_lysosome_morphology0.72016663
137MP0005389_reproductive_system_phenotype0.71881450
138MP0004019_abnormal_vitamin_homeostasis0.71792789
139MP0008995_early_reproductive_senescence0.71521279
140MP0001790_abnormal_immune_system0.71316973
141MP0005387_immune_system_phenotype0.71316973
142MP0001542_abnormal_bone_strength0.71253752
143MP0001186_pigmentation_phenotype0.71066158
144MP0002933_joint_inflammation0.70817042
145MP0009931_abnormal_skin_appearance0.70365068
146MP0001756_abnormal_urination0.69988467
147MP0002118_abnormal_lipid_homeostasis0.69838178
148MP0002909_abnormal_adrenal_gland0.69732093
149MP0003011_delayed_dark_adaptation0.68834239
150MP0002420_abnormal_adaptive_immunity0.68584184
151MP0008058_abnormal_DNA_repair0.67632140
152MP0004215_abnormal_myocardial_fiber0.67242210
153MP0000470_abnormal_stomach_morphology0.64435167
154MP0002136_abnormal_kidney_physiology0.61972040
155MP0003638_abnormal_response/metabolism_0.59599851
156MP0009053_abnormal_anal_canal0.59319675
157MP0003646_muscle_fatigue0.59108527
158MP0003890_abnormal_embryonic-extraembry0.57124465
159MP0002254_reproductive_system_inflammat0.56760578
160MP0006036_abnormal_mitochondrial_physio0.55701323
161MP0000230_abnormal_systemic_arterial0.55082459

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)6.81594960
2Type I transferrin isoform profile (HP:0003642)6.62377849
3Hypothermia (HP:0002045)5.24830905
4Plantar hyperkeratosis (HP:0007556)5.11511104
5Abnormal protein glycosylation (HP:0012346)5.09688664
6Abnormal glycosylation (HP:0012345)5.09688664
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.09688664
8Abnormal protein N-linked glycosylation (HP:0012347)5.09688664
9Palmoplantar hyperkeratosis (HP:0000972)4.79240452
10Onycholysis (HP:0001806)4.79057277
11Palmar hyperkeratosis (HP:0010765)4.60569115
12Right ventricular cardiomyopathy (HP:0011663)4.56384188
13Thyroid-stimulating hormone excess (HP:0002925)4.45391993
14Prolonged partial thromboplastin time (HP:0003645)4.22909317
15Fragile nails (HP:0001808)3.98290407
16Abnormality of nail color (HP:0100643)3.94046572
17Alopecia of scalp (HP:0002293)3.75439544
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.63347356
19Pili torti (HP:0003777)3.46159419
20Woolly hair (HP:0002224)3.38149026
21Milia (HP:0001056)3.35699751
22Hypotrichosis (HP:0001006)3.33068402
23Abnormal number of erythroid precursors (HP:0012131)3.29499518
24Abnormality of cells of the erythroid lineage (HP:0012130)3.29499098
25Abnormal hair laboratory examination (HP:0003328)3.20519985
26Erythroderma (HP:0001019)3.18456691
273-Methylglutaconic aciduria (HP:0003535)3.06419646
28Congenital ichthyosiform erythroderma (HP:0007431)3.02578776
29Sparse eyelashes (HP:0000653)3.01826633
30Thick nail (HP:0001805)2.97172509
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95900026
32Symptomatic seizures (HP:0011145)2.95543317
33Late onset (HP:0003584)2.90866183
34Split foot (HP:0001839)2.82984125
35Hyperinsulinemic hypoglycemia (HP:0000825)2.74753590
36Fair hair (HP:0002286)2.73837891
37Cortical visual impairment (HP:0100704)2.72591085
38Hypoglycemic seizures (HP:0002173)2.71229038
39Renal Fanconi syndrome (HP:0001994)2.65815237
40Conjunctival hamartoma (HP:0100780)2.65757077
41Aplasia/hypoplasia of the uterus (HP:0008684)2.65441660
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65121746
43Increased hepatocellular lipid droplets (HP:0006565)2.62371383
44Abnormality of the axillary hair (HP:0100134)2.60047279
45Abnormality of secondary sexual hair (HP:0009888)2.60047279
46Oral leukoplakia (HP:0002745)2.58070401
47Abnormality of magnesium homeostasis (HP:0004921)2.54872639
48Abnormal rod and cone electroretinograms (HP:0008323)2.53671986
49Congenital, generalized hypertrichosis (HP:0004540)2.49520767
50Generalized aminoaciduria (HP:0002909)2.47256208
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46096985
52Intrahepatic cholestasis (HP:0001406)2.45910848
53Macrocytic anemia (HP:0001972)2.45744863
54Furrowed tongue (HP:0000221)2.41226653
55Reticulocytopenia (HP:0001896)2.41174568
56Lipid accumulation in hepatocytes (HP:0006561)2.39028154
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38313173
58Conjugated hyperbilirubinemia (HP:0002908)2.38190212
59Nail dystrophy (HP:0008404)2.36428673
60Decreased circulating renin level (HP:0003351)2.35642940
61Abnormality of calcium-phosphate metabolism (HP:0100530)2.34613470
62Palpitations (HP:0001962)2.33695889
63Severe visual impairment (HP:0001141)2.31735096
64Exertional dyspnea (HP:0002875)2.31193373
65Lip pit (HP:0100267)2.30740004
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30199169
67Abnormal sex determination (HP:0012244)2.29771093
68Sex reversal (HP:0012245)2.29771093
69Hypobetalipoproteinemia (HP:0003563)2.27835804
70Microvesicular hepatic steatosis (HP:0001414)2.27526248
71Flat occiput (HP:0005469)2.25889507
72Hypoglycemic coma (HP:0001325)2.23056361
73Abnormal biliary tract morphology (HP:0012440)2.22944646
74Attenuation of retinal blood vessels (HP:0007843)2.22420434
75Vacuolated lymphocytes (HP:0001922)2.19247645
76Abnormality of urine glucose concentration (HP:0011016)2.18586776
77Glycosuria (HP:0003076)2.18586776
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18479317
79Progressive muscle weakness (HP:0003323)2.17714228
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15957533
81Abnormality of alanine metabolism (HP:0010916)2.15957533
82Hyperalaninemia (HP:0003348)2.15957533
83Abnormality of vitamin B metabolism (HP:0004340)2.15427632
84Nonprogressive disorder (HP:0003680)2.15153245
85Abnormality of the renal cortex (HP:0011035)2.15145754
86Pancreatic fibrosis (HP:0100732)2.14771538
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13658314
88Hamartoma of the eye (HP:0010568)2.13602503
89Hypoplastic labia majora (HP:0000059)2.12773290
90Hepatic necrosis (HP:0002605)2.12569687
91Abnormality of placental membranes (HP:0011409)2.11527664
92Amniotic constriction ring (HP:0009775)2.11527664
93Palmoplantar keratoderma (HP:0000982)2.10517874
94Proximal tubulopathy (HP:0000114)2.10079741
95True hermaphroditism (HP:0010459)2.09465750
96Corneal erosion (HP:0200020)2.09185739
97Hypoplasia of the fovea (HP:0007750)2.08687947
98Aplasia/Hypoplasia of the fovea (HP:0008060)2.08687947
99Hyperglycinemia (HP:0002154)2.08168693
100Curly hair (HP:0002212)2.08120189
101Congenital stationary night blindness (HP:0007642)2.07480862
102Parakeratosis (HP:0001036)2.06479283
103Renal cortical cysts (HP:0000803)2.05685229
104Abnormality of vitamin metabolism (HP:0100508)2.04974923
105Hyperphosphaturia (HP:0003109)2.04267920
106Insulin-resistant diabetes mellitus (HP:0000831)2.04089157
107Hepatocellular necrosis (HP:0001404)2.03234817
108Dehydration (HP:0001944)2.00701845
109Erythema (HP:0010783)1.99909301
110Abdominal distention (HP:0003270)1.99647029
111Confusion (HP:0001289)1.99533530
112Abnormality of renal resorption (HP:0011038)1.98220447
113Abnormality of proline metabolism (HP:0010907)1.97830146
114Hydroxyprolinuria (HP:0003080)1.97830146
115Microcytic anemia (HP:0001935)1.96373868
116Abnormality of the vitamin B12 metabolism (HP:0004341)1.96303444
117Pallor (HP:0000980)1.95405815
118Abnormal blistering of the skin (HP:0008066)1.94475764
119Insulin resistance (HP:0000855)1.94218346
120Hyperparathyroidism (HP:0000843)1.94159799
121Metabolic alkalosis (HP:0200114)1.94111196
122Vascular calcification (HP:0004934)1.91292435
123Hypoplasia of dental enamel (HP:0006297)1.90594727
124Abnormality of dental color (HP:0011073)1.90565528
125Aplastic anemia (HP:0001915)1.89904675
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88913578
127Generalized hypopigmentation of hair (HP:0011358)1.87489428
128Epidermoid cyst (HP:0200040)1.86632017
129Abnormality of the labia majora (HP:0012881)1.85531094
130Tubular atrophy (HP:0000092)1.84571146
131Congenital sensorineural hearing impairment (HP:0008527)1.83687418
132Hyperglycinuria (HP:0003108)1.83644263
133Pancreatic cysts (HP:0001737)1.83461381
134Increased intramyocellular lipid droplets (HP:0012240)1.82187713
135Hypomagnesemia (HP:0002917)1.80617343
136Hyperglycemia (HP:0003074)1.80324750
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80231931
138Type 2 muscle fiber atrophy (HP:0003554)1.80044942
139Petechiae (HP:0000967)1.79968145
140Hyperphosphatemia (HP:0002905)1.79448970
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.79278386
142Abnormality of T cell physiology (HP:0011840)1.79160400
143Sparse scalp hair (HP:0002209)1.78287440
144Absent eyelashes (HP:0000561)1.78223403
145Osteomalacia (HP:0002749)1.78000262
146Hyperaldosteronism (HP:0000859)1.77396623
147Fat malabsorption (HP:0002630)1.77239129
148Pendular nystagmus (HP:0012043)1.77169335
149Ridged nail (HP:0001807)1.76421453
150Hyperactive renin-angiotensin system (HP:0000841)1.76014798
151Azoospermia (HP:0000027)1.75266938
152Lower limb hyperreflexia (HP:0002395)1.74348557
153Dry hair (HP:0011359)1.73663126
154Abnormal urine phosphate concentration (HP:0012599)1.73483777
155Alkalosis (HP:0001948)1.72703996
156Ectropion (HP:0000656)1.72385925
157Abnormal spermatogenesis (HP:0008669)1.72282349
158Abnormality of the fovea (HP:0000493)1.72070384
159Abnormality of chloride homeostasis (HP:0011422)1.71325777
160Renal tubular dysfunction (HP:0000124)1.70542303
161Chorioretinal atrophy (HP:0000533)1.70416839
162Menorrhagia (HP:0000132)1.69584187
163Hyperbilirubinemia (HP:0002904)1.69242591
164Amelogenesis imperfecta (HP:0000705)1.68432945
165Increased CSF lactate (HP:0002490)1.68316508
166Gaze-evoked nystagmus (HP:0000640)1.67951451
167Thrombocytosis (HP:0001894)1.67771252
168Type II lissencephaly (HP:0007260)1.67687083
169Hypoplasia of the uterus (HP:0000013)1.67276722
170Muscle fiber atrophy (HP:0100295)1.66863387
171Abnormality of glycine metabolism (HP:0010895)1.66826740
172Abnormality of serine family amino acid metabolism (HP:0010894)1.66826740
173Abnormality of the common coagulation pathway (HP:0010990)1.66763981
174Abnormality of renin-angiotensin system (HP:0000847)1.66457788
175Restlessness (HP:0000711)1.66075981
176Capillary hemangiomas (HP:0005306)1.65104384
177Progressive neurologic deterioration (HP:0002344)1.63722498
178Dysostosis multiplex (HP:0000943)1.63428902
179Joint hemorrhage (HP:0005261)1.62501664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.83068950
2NLK3.86497419
3EIF2AK33.71471876
4STK163.23286450
5IRAK33.00262870
6MKNK22.78982031
7STK392.74902087
8MUSK2.54212601
9INSRR2.49696084
10CASK2.48128046
11OXSR12.32612542
12STK38L2.26572387
13NME22.26396380
14MAP3K122.24377247
15PBK2.15766982
16MET2.06684807
17STK242.02384944
18IRAK42.01573369
19WNK42.00343777
20MAPK151.98712891
21TAOK31.94653562
22LATS11.93546151
23CAMKK21.85012690
24TRIM281.77452574
25TEC1.67476363
26MAP4K21.67021679
27IRAK11.65900178
28STK31.64480888
29LMTK21.57183265
30TLK11.55340945
31MAPKAPK31.54280233
32MKNK11.51491425
33ERBB31.47619952
34PASK1.40864672
35SRPK11.36376206
36EIF2AK21.35229321
37PIM21.32949233
38BCR1.32161297
39FLT31.31186750
40VRK11.30570588
41PIK3CA1.27413185
42KIT1.25254765
43IRAK21.21741934
44DYRK31.21208179
45HIPK21.17916681
46BRSK21.16613537
47PIK3CG1.16292417
48BUB11.11861453
49WEE11.11202619
50TGFBR11.10083810
51PRKD21.05886975
52PRKCE1.03804650
53NEK11.03335696
54MAP3K21.01996598
55PHKG10.97155080
56PHKG20.97155080
57TXK0.95926221
58TAF10.95720382
59YES10.94929389
60TRPM70.94193440
61FES0.92651188
62MST40.92198428
63CDK190.89409966
64MAP2K20.81820152
65BLK0.79845688
66PRKG20.79721586
67ADRBK20.78998643
68IKBKB0.75931155
69ERBB40.75422261
70TESK20.74749303
71RPS6KB20.73691289
72FGFR20.73474350
73CAMK10.71976543
74ACVR1B0.71797990
75MAP3K10.71634364
76IKBKE0.70079010
77BTK0.69892963
78VRK20.65478830
79ZAP700.65190190
80NUAK10.63835471
81BMPR1B0.60733234
82CDK30.59662829
83ZAK0.59207802
84PLK40.59142613
85MAP3K140.58479872
86BCKDK0.57976789
87MAP2K70.55895015
88PLK30.55615775
89TIE10.55240935
90PLK20.54870289
91CLK10.54511920
92MAPKAPK50.53892095
93NEK20.53495093
94ADRBK10.53152251
95PDK20.53096845
96GRK10.52605223
97WNK30.51462899
98CSNK1A1L0.50946853
99MAP3K90.50726443
100LYN0.50350457
101FRK0.49922518
102FGFR10.48845467
103JAK30.48816181
104CSNK1G10.48753176
105TSSK60.48156693
106TBK10.47640321
107DYRK20.47319384
108MST1R0.47133022
109STK380.46389632
110CAMK2B0.46363664
111CSNK1A10.45249148
112NEK60.43563173
113MAP2K60.43508096
114TTK0.42642529
115MAPK40.42313901
116PRKAA20.41900658
117DYRK1B0.41817710
118MAPK130.41108783
119AKT30.40216564
120NME10.39491029
121ABL20.39469251
122KDR0.39192403
123MAP3K40.38839463
124MYLK0.38737144
125PAK30.38668433
126SIK30.38430464
127SYK0.38239734
128TGFBR20.38188927
129EIF2AK10.37730383
130PLK10.36815543
131PTK20.36417073
132EPHA20.35727947
133LCK0.35524172
134IGF1R0.34633537
135BMPR20.33332726
136RPS6KA40.33292568
137PNCK0.32958553
138MATK0.32786065
139TYK20.32745094
140CCNB10.32703603
141CSNK1G30.32490936
142RPS6KA50.31892183
143GRK70.31772724
144EPHA30.30995366
145CSNK1G20.30598969
146MAP3K30.30394090
147CSK0.30209182
148UHMK10.29276585
149CHUK0.29077866
150PRKCI0.28218077
151CSNK2A10.27546986
152PINK10.26651776
153CAMK2D0.26020972
154CDK80.24653698
155CSNK2A20.24115663
156FER0.23880938

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.93963576
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.49153132
3Ribosome_Homo sapiens_hsa030103.51604925
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13580975
5Caffeine metabolism_Homo sapiens_hsa002322.95325495
6Folate biosynthesis_Homo sapiens_hsa007902.63067734
7RNA polymerase_Homo sapiens_hsa030202.33098289
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.15797359
9Nitrogen metabolism_Homo sapiens_hsa009102.08525845
10Tryptophan metabolism_Homo sapiens_hsa003802.01156479
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96805111
12Sulfur metabolism_Homo sapiens_hsa009201.94339718
13N-Glycan biosynthesis_Homo sapiens_hsa005101.93797154
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93010441
15Butanoate metabolism_Homo sapiens_hsa006501.91640830
16Other glycan degradation_Homo sapiens_hsa005111.88572112
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85482482
18Pyrimidine metabolism_Homo sapiens_hsa002401.82842758
19Regulation of autophagy_Homo sapiens_hsa041401.81710864
20Propanoate metabolism_Homo sapiens_hsa006401.80079967
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78295700
22Fatty acid degradation_Homo sapiens_hsa000711.77469643
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71207739
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69936471
25DNA replication_Homo sapiens_hsa030301.66489514
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.65593259
27Thyroid cancer_Homo sapiens_hsa052161.61664982
28Sphingolipid metabolism_Homo sapiens_hsa006001.59775075
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59025385
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53142500
31Homologous recombination_Homo sapiens_hsa034401.49457925
32Vitamin digestion and absorption_Homo sapiens_hsa049771.46888803
33Mineral absorption_Homo sapiens_hsa049781.31471788
34Arachidonic acid metabolism_Homo sapiens_hsa005901.28207730
35Peroxisome_Homo sapiens_hsa041461.27815081
36Histidine metabolism_Homo sapiens_hsa003401.25777235
37Purine metabolism_Homo sapiens_hsa002301.23182099
38Arginine biosynthesis_Homo sapiens_hsa002201.21461372
39Linoleic acid metabolism_Homo sapiens_hsa005911.19853589
40Sulfur relay system_Homo sapiens_hsa041221.17597028
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16339919
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.11051531
43Fatty acid elongation_Homo sapiens_hsa000621.10481407
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09185102
45Fatty acid metabolism_Homo sapiens_hsa012121.08419085
46Vitamin B6 metabolism_Homo sapiens_hsa007501.08065419
47Proteasome_Homo sapiens_hsa030501.06227551
48beta-Alanine metabolism_Homo sapiens_hsa004101.05251613
49Phenylalanine metabolism_Homo sapiens_hsa003601.04871052
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04715957
51Basal transcription factors_Homo sapiens_hsa030221.04045358
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03417256
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00727984
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00012617
55Pyruvate metabolism_Homo sapiens_hsa006200.99292386
56ABC transporters_Homo sapiens_hsa020100.99194650
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.99105343
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98259513
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97439987
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96682901
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.94031378
62Bile secretion_Homo sapiens_hsa049760.93654259
63Fanconi anemia pathway_Homo sapiens_hsa034600.92577299
64Type I diabetes mellitus_Homo sapiens_hsa049400.91529665
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90334407
66Tyrosine metabolism_Homo sapiens_hsa003500.89907972
67Hematopoietic cell lineage_Homo sapiens_hsa046400.89745755
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89005769
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.88743670
70PPAR signaling pathway_Homo sapiens_hsa033200.88684453
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88437459
72Primary immunodeficiency_Homo sapiens_hsa053400.86997366
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86798197
74Spliceosome_Homo sapiens_hsa030400.86636317
75Fatty acid biosynthesis_Homo sapiens_hsa000610.85183803
76Glycerolipid metabolism_Homo sapiens_hsa005610.85148975
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83118149
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79846607
79Ether lipid metabolism_Homo sapiens_hsa005650.79828890
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.79202613
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.78740351
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78092645
83Retinol metabolism_Homo sapiens_hsa008300.75776006
84Allograft rejection_Homo sapiens_hsa053300.74169495
85Nucleotide excision repair_Homo sapiens_hsa034200.72605036
86Selenocompound metabolism_Homo sapiens_hsa004500.72105937
87Metabolic pathways_Homo sapiens_hsa011000.69828310
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69796515
89Oxidative phosphorylation_Homo sapiens_hsa001900.68294821
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67520654
91Vibrio cholerae infection_Homo sapiens_hsa051100.66655216
92Circadian rhythm_Homo sapiens_hsa047100.66391667
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65987848
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65850604
95Insulin secretion_Homo sapiens_hsa049110.65570236
96Antigen processing and presentation_Homo sapiens_hsa046120.64809553
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64650760
98Mismatch repair_Homo sapiens_hsa034300.64610751
99Graft-versus-host disease_Homo sapiens_hsa053320.64567354
100Base excision repair_Homo sapiens_hsa034100.60852459
101Steroid biosynthesis_Homo sapiens_hsa001000.60314400
102Lysosome_Homo sapiens_hsa041420.58753110
103p53 signaling pathway_Homo sapiens_hsa041150.56898569
104Fat digestion and absorption_Homo sapiens_hsa049750.56504528
105Autoimmune thyroid disease_Homo sapiens_hsa053200.56098148
106Renin-angiotensin system_Homo sapiens_hsa046140.55692324
107Measles_Homo sapiens_hsa051620.54360490
108Ovarian steroidogenesis_Homo sapiens_hsa049130.53717164
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52304862
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52130341
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49672698
112Pentose phosphate pathway_Homo sapiens_hsa000300.49489361
113One carbon pool by folate_Homo sapiens_hsa006700.49059787
114Asthma_Homo sapiens_hsa053100.47566191
115Glutathione metabolism_Homo sapiens_hsa004800.47263355
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46763245
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.46151865
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.46007360
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44423867
120Herpes simplex infection_Homo sapiens_hsa051680.43973975
121Chemical carcinogenesis_Homo sapiens_hsa052040.43548351
122Non-homologous end-joining_Homo sapiens_hsa034500.42916363
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42839425
124Starch and sucrose metabolism_Homo sapiens_hsa005000.42426542
125Rheumatoid arthritis_Homo sapiens_hsa053230.42398920
126RNA degradation_Homo sapiens_hsa030180.41844863
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40154781
128Phototransduction_Homo sapiens_hsa047440.39895884
129Arginine and proline metabolism_Homo sapiens_hsa003300.39183707
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39008043
131Pancreatic secretion_Homo sapiens_hsa049720.37589464
132Complement and coagulation cascades_Homo sapiens_hsa046100.34094436
133Parkinsons disease_Homo sapiens_hsa050120.32273695
134Serotonergic synapse_Homo sapiens_hsa047260.31746385
135Galactose metabolism_Homo sapiens_hsa000520.31380667
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31244869
137Tight junction_Homo sapiens_hsa045300.30082042
138Collecting duct acid secretion_Homo sapiens_hsa049660.27360858
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27185849
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25471784

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