NIPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.15307210
2central nervous system myelination (GO:0022010)8.15307210
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)7.87933967
4potassium ion export (GO:0071435)6.90858907
5membrane repolarization during action potential (GO:0086011)6.87773303
6regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.18020613
7synaptic vesicle docking involved in exocytosis (GO:0016081)6.17783549
8membrane repolarization (GO:0086009)5.84356059
9fatty acid elongation (GO:0030497)5.49855253
10positive regulation of potassium ion transmembrane transport (GO:1901381)5.19297924
11long-chain fatty acid biosynthetic process (GO:0042759)5.15023691
12myelination (GO:0042552)5.07520225
13ensheathment of neurons (GO:0007272)5.04119941
14axon ensheathment (GO:0008366)5.04119941
15negative regulation of neurotransmitter transport (GO:0051589)4.69894253
16cellular potassium ion homeostasis (GO:0030007)4.61969937
17negative regulation of neurotransmitter secretion (GO:0046929)4.59911935
18neurotransmitter secretion (GO:0007269)4.42895618
19regulation of heart rate by cardiac conduction (GO:0086091)4.38941871
20neuron cell-cell adhesion (GO:0007158)4.38910511
21L-amino acid import (GO:0043092)4.36759499
22sodium ion export (GO:0071436)4.30959595
23presynaptic membrane organization (GO:0097090)4.25386481
24presynaptic membrane assembly (GO:0097105)4.22260833
25spermatid nucleus differentiation (GO:0007289)4.18306893
26regulation of membrane repolarization (GO:0060306)4.13709020
27positive regulation of potassium ion transport (GO:0043268)3.99511530
28positive regulation of dendritic spine morphogenesis (GO:0061003)3.98799347
29synaptic vesicle maturation (GO:0016188)3.95955375
30neuronal action potential propagation (GO:0019227)3.94970325
31establishment of mitochondrion localization (GO:0051654)3.91460404
32cellular sodium ion homeostasis (GO:0006883)3.86040523
33cardiac conduction (GO:0061337)3.84509331
34negative regulation of protein localization to cell surface (GO:2000009)3.79670149
35transmission of nerve impulse (GO:0019226)3.77185476
36dendritic spine morphogenesis (GO:0060997)3.75926280
37ventricular cardiac muscle cell action potential (GO:0086005)3.68489357
38neurotransmitter transport (GO:0006836)3.65547187
39cholesterol biosynthetic process (GO:0006695)3.58895812
40response to methylmercury (GO:0051597)3.53621227
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52859806
42myelin maintenance (GO:0043217)3.51191136
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51000040
44neuron recognition (GO:0008038)3.50298584
45exploration behavior (GO:0035640)3.48529790
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48089977
47adult walking behavior (GO:0007628)3.47426321
48synaptic vesicle exocytosis (GO:0016079)3.47053749
49cerebral cortex radially oriented cell migration (GO:0021799)3.45569559
50regulation of collateral sprouting (GO:0048670)3.45290427
51eye photoreceptor cell differentiation (GO:0001754)3.45084525
52photoreceptor cell differentiation (GO:0046530)3.45084525
53negative regulation of dendrite morphogenesis (GO:0050774)3.40591201
54regulation of synaptic vesicle exocytosis (GO:2000300)3.38391643
55acrosome assembly (GO:0001675)3.37309501
56positive regulation of synapse maturation (GO:0090129)3.37208597
57neuronal ion channel clustering (GO:0045161)3.36987012
58glycerophospholipid catabolic process (GO:0046475)3.35776224
59potassium ion homeostasis (GO:0055075)3.34660655
60ionotropic glutamate receptor signaling pathway (GO:0035235)3.32392721
61positive regulation of dendritic spine development (GO:0060999)3.31673006
62axonal fasciculation (GO:0007413)3.31359551
63amino acid import (GO:0043090)3.30481200
64vocalization behavior (GO:0071625)3.28147364
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.26944778
66oligodendrocyte differentiation (GO:0048709)3.26460037
67protein localization to synapse (GO:0035418)3.25928666
68glutamate secretion (GO:0014047)3.23317624
69apical protein localization (GO:0045176)3.23110389
70neuromuscular process controlling balance (GO:0050885)3.22724125
71locomotory exploration behavior (GO:0035641)3.22679292
72sterol biosynthetic process (GO:0016126)3.20775556
73cerebellar Purkinje cell differentiation (GO:0021702)3.19441100
74negative regulation of axonogenesis (GO:0050771)3.18342536
75synaptic vesicle endocytosis (GO:0048488)3.15632915
76cell communication by electrical coupling (GO:0010644)3.14571484
77cardiac muscle cell action potential involved in contraction (GO:0086002)3.14269279
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12884678
79regulation of neuronal synaptic plasticity (GO:0048168)3.12594031
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11484330
81nerve growth factor signaling pathway (GO:0038180)3.11061128
82multicellular organismal signaling (GO:0035637)3.10824176
83import into cell (GO:0098657)3.07500521
84regulation of neurotransmitter levels (GO:0001505)3.04419355
85cardiac muscle cell action potential (GO:0086001)3.04005290
86regulation of synaptic plasticity (GO:0048167)3.03068372
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.02004043
88asymmetric protein localization (GO:0008105)3.01874787
89regulation of neurotransmitter secretion (GO:0046928)3.01744149
90regulation of potassium ion transmembrane transporter activity (GO:1901016)3.01220362
91synaptic transmission, glutamatergic (GO:0035249)3.01175975
92astrocyte development (GO:0014002)3.00933302
93neuron-neuron synaptic transmission (GO:0007270)2.99977248
94glutamate receptor signaling pathway (GO:0007215)2.99431061
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.98877254
96gamma-aminobutyric acid transport (GO:0015812)2.97801519
97dendrite morphogenesis (GO:0048813)2.97327669
98isoprenoid biosynthetic process (GO:0008299)2.97020960
99negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.96388952
100signal release (GO:0023061)2.94410732
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93979636
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93260574
103substantia nigra development (GO:0021762)2.92593931
104potassium ion import (GO:0010107)2.91076189
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90178825
106auditory behavior (GO:0031223)2.89465912
107suckling behavior (GO:0001967)2.89146833
108cell differentiation in hindbrain (GO:0021533)2.87773232
109neuron remodeling (GO:0016322)2.86838635
110serotonin metabolic process (GO:0042428)2.86768011
111neurotransmitter uptake (GO:0001504)2.86045199
112long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.85564713
113cerebellar granule cell differentiation (GO:0021707)2.85511202
114negative regulation of axon extension (GO:0030517)2.84478907
115cochlea development (GO:0090102)2.83483633
116neuromuscular process controlling posture (GO:0050884)2.82880878
117layer formation in cerebral cortex (GO:0021819)2.82491053
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.81960851
119glycine transport (GO:0015816)2.81108498
120regulation of synaptic vesicle transport (GO:1902803)2.79504568
121negative regulation of inclusion body assembly (GO:0090084)2.78184474
122mechanosensory behavior (GO:0007638)2.77322119
123regulation of potassium ion transmembrane transport (GO:1901379)2.77129036
124regulation of glutamate receptor signaling pathway (GO:1900449)2.76268064
125regulation of synapse structural plasticity (GO:0051823)2.75372654
126long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.74249566
127protein palmitoylation (GO:0018345)2.71970420
128long-term memory (GO:0007616)2.71216379
129regulation of ARF protein signal transduction (GO:0032012)2.70440196
130insulin secretion (GO:0030073)2.69859602
131peripheral nervous system axon ensheathment (GO:0032292)2.69539052
132myelination in peripheral nervous system (GO:0022011)2.69539052
133membrane tubulation (GO:0097320)2.66122808
134detection of calcium ion (GO:0005513)2.65187767
135regulation of vesicle fusion (GO:0031338)2.65119153
136regulation of dendritic spine morphogenesis (GO:0061001)2.64178061
137postsynaptic membrane organization (GO:0001941)2.64116743
138positive regulation of membrane potential (GO:0045838)2.63396837
139neurotransmitter-gated ion channel clustering (GO:0072578)2.62665958
140regulation of voltage-gated calcium channel activity (GO:1901385)2.61740066
141dendrite development (GO:0016358)2.61191597
142membrane assembly (GO:0071709)2.60795246
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58222731
144limb bud formation (GO:0060174)2.57444937
145response to auditory stimulus (GO:0010996)2.56988035
146mating behavior (GO:0007617)2.56736851
147adult locomotory behavior (GO:0008344)2.56729365
148detection of temperature stimulus involved in sensory perception (GO:0050961)2.54221825
149detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.54221825
150regulation of dendritic spine development (GO:0060998)2.54086734
151long-term synaptic potentiation (GO:0060291)2.54034878
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53854122
153substrate-independent telencephalic tangential migration (GO:0021826)2.53207059
154substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.53207059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19751033
2GBX2_23144817_ChIP-Seq_PC3_Human3.77849857
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84961367
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77149141
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70773164
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36402948
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36402948
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.34533877
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30918196
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28541591
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27645389
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27167327
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25675661
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23581577
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21743147
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.19984540
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.19186718
18AR_21572438_ChIP-Seq_LNCaP_Human2.08075654
19TAF15_26573619_Chip-Seq_HEK293_Human2.07293972
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.07271760
21DROSHA_22980978_ChIP-Seq_HELA_Human2.05167719
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02481464
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99407225
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96531371
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.95436854
26REST_21632747_ChIP-Seq_MESCs_Mouse1.94222434
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87803437
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.79209696
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77835306
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77292098
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73218721
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70905556
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68649722
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66354321
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65114822
36KDM2B_26808549_Chip-Seq_K562_Human1.64895868
37* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.61129388
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.59805896
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59035175
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58662696
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.58050676
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56702855
43ER_23166858_ChIP-Seq_MCF-7_Human1.56039227
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55348263
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55160989
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.54904922
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.54081346
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52526130
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51970786
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50602638
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.50309793
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49073960
53P300_19829295_ChIP-Seq_ESCs_Human1.48980041
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48808223
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48511117
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48363848
57SMAD4_21799915_ChIP-Seq_A2780_Human1.45477648
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.45059104
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41492191
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40484978
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40144762
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39976952
63STAT3_23295773_ChIP-Seq_U87_Human1.33579075
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31956484
65FUS_26573619_Chip-Seq_HEK293_Human1.31780667
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30161440
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29624965
68AR_19668381_ChIP-Seq_PC3_Human1.29092055
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26561473
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24828566
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23730499
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21695258
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20563999
74VDR_22108803_ChIP-Seq_LS180_Human1.20206748
75TCF4_23295773_ChIP-Seq_U87_Human1.18698720
76SOX9_26525672_Chip-Seq_HEART_Mouse1.18521882
77RNF2_27304074_Chip-Seq_NSC_Mouse1.16569273
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16135629
79RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14816394
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14105514
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.13742196
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.13599331
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11891034
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11650605
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11416897
86IGF1R_20145208_ChIP-Seq_DFB_Human1.11415936
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11254018
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10991285
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10772255
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.10134174
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09621210
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08707914
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08315726
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08299274
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.08061928
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.07447091
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.07292635
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.07163200
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07008910
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06931776
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06833491
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.06353376
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05991789
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.05416919
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.04594783
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.03408310
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03373721
108TP53_16413492_ChIP-PET_HCT116_Human1.03278276
109POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.03179293
110RUNX2_22187159_ChIP-Seq_PCA_Human1.01902702
111AHR_22903824_ChIP-Seq_MCF-7_Human1.01801700
112AR_25329375_ChIP-Seq_VCAP_Human1.01246368
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01031732
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98126582
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.97493786
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97349303
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97106242
118WT1_19549856_ChIP-ChIP_CCG9911_Human0.96716652
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96674351
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96403235
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96403235
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.96090065
123TP53_18474530_ChIP-ChIP_U2OS_Human0.95361040
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95352666
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.95316162
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.95191566
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94759323
128P300_18555785_Chip-Seq_ESCs_Mouse0.93500195
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.92058494
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92047907
131JUN_21703547_ChIP-Seq_K562_Human0.91757395
132P53_22387025_ChIP-Seq_ESCs_Mouse0.90691676
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.90557636
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90269800
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90269800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.52988972
2MP0004859_abnormal_synaptic_plasticity4.48490759
3MP0003878_abnormal_ear_physiology4.14059677
4MP0005377_hearing/vestibular/ear_phenot4.14059677
5MP0004270_analgesia3.89396261
6MP0000920_abnormal_myelination3.70836912
7MP0003635_abnormal_synaptic_transmissio3.10318078
8MP0001986_abnormal_taste_sensitivity2.88678616
9MP0001486_abnormal_startle_reflex2.87137530
10MP0002064_seizures2.85031071
11MP0002272_abnormal_nervous_system2.73330301
12MP0009745_abnormal_behavioral_response2.72850120
13MP0005423_abnormal_somatic_nervous2.60383578
14MP0003690_abnormal_glial_cell2.51863139
15MP0009046_muscle_twitch2.51667188
16MP0003329_amyloid_beta_deposits2.49791292
17MP0002063_abnormal_learning/memory/cond2.44563811
18MP0002734_abnormal_mechanical_nocicepti2.39192355
19MP0001529_abnormal_vocalization2.37014791
20MP0000778_abnormal_nervous_system2.37005025
21MP0004885_abnormal_endolymph2.27816219
22MP0004742_abnormal_vestibular_system2.21876575
23MP0002572_abnormal_emotion/affect_behav2.21030827
24MP0001905_abnormal_dopamine_level2.11207095
25MP0005409_darkened_coat_color1.99652025
26MP0004142_abnormal_muscle_tone1.99337408
27MP0001968_abnormal_touch/_nociception1.96713122
28MP0002822_catalepsy1.92573458
29MP0003634_abnormal_glial_cell1.88749332
30MP0001440_abnormal_grooming_behavior1.81540957
31MP0005187_abnormal_penis_morphology1.81527183
32MP0001485_abnormal_pinna_reflex1.81264055
33MP0002735_abnormal_chemical_nociception1.77895387
34MP0005171_absent_coat_pigmentation1.76869468
35MP0003123_paternal_imprinting1.74962789
36MP0002067_abnormal_sensory_capabilities1.71687482
37MP0000955_abnormal_spinal_cord1.70388070
38MP0008569_lethality_at_weaning1.69858773
39MP0004924_abnormal_behavior1.69070158
40MP0005386_behavior/neurological_phenoty1.69070158
41MP0001970_abnormal_pain_threshold1.67406661
42MP0003136_yellow_coat_color1.65868721
43MP0003632_abnormal_nervous_system1.63553795
44MP0002733_abnormal_thermal_nociception1.61241454
45MP0002229_neurodegeneration1.61062841
46MP0002882_abnormal_neuron_morphology1.60020615
47MP0003950_abnormal_plasma_membrane1.53526957
48MP0003631_nervous_system_phenotype1.52302643
49MP0002736_abnormal_nociception_after1.48974534
50MP0003633_abnormal_nervous_system1.47531744
51MP0002066_abnormal_motor_capabilities/c1.46900675
52MP0005646_abnormal_pituitary_gland1.43149596
53MP0001501_abnormal_sleep_pattern1.37512318
54MP0002184_abnormal_innervation1.34560918
55MP0003122_maternal_imprinting1.33933909
56MP0005551_abnormal_eye_electrophysiolog1.33722870
57MP0002557_abnormal_social/conspecific_i1.31448118
58MP0004811_abnormal_neuron_physiology1.29422295
59MP0005645_abnormal_hypothalamus_physiol1.23306273
60MP0001188_hyperpigmentation1.21921274
61MP0001963_abnormal_hearing_physiology1.20904743
62MP0000604_amyloidosis1.19120873
63MP0009780_abnormal_chondrocyte_physiolo1.19048546
64MP0002160_abnormal_reproductive_system1.17706685
65MP0001177_atelectasis1.14261391
66MP0001299_abnormal_eye_distance/1.14175378
67MP0006276_abnormal_autonomic_nervous1.13621716
68MP0002752_abnormal_somatic_nervous1.12200229
69MP0008057_abnormal_DNA_replication1.12076863
70MP0000569_abnormal_digit_pigmentation1.11242483
71MP0004147_increased_porphyrin_level1.10211011
72MP0002877_abnormal_melanocyte_morpholog1.09956566
73MP0002152_abnormal_brain_morphology1.09930004
74MP0003283_abnormal_digestive_organ1.05979693
75MP0001919_abnormal_reproductive_system1.05237324
76MP0004215_abnormal_myocardial_fiber1.02828885
77MP0004043_abnormal_pH_regulation1.02555734
78MP0005410_abnormal_fertilization1.01557965
79MP0001984_abnormal_olfaction0.99404456
80MP0002909_abnormal_adrenal_gland0.96991008
81MP0001502_abnormal_circadian_rhythm0.95790673
82MP0003890_abnormal_embryonic-extraembry0.94137754
83MP0004134_abnormal_chest_morphology0.93769635
84MP0000462_abnormal_digestive_system0.90787409
85MP0005623_abnormal_meninges_morphology0.88429138
86MP0000566_synostosis0.87851787
87MP0010678_abnormal_skin_adnexa0.87768474
88MP0001348_abnormal_lacrimal_gland0.87128564
89MP0004858_abnormal_nervous_system0.85346025
90MP0000026_abnormal_inner_ear0.84248772
91MP0000631_abnormal_neuroendocrine_gland0.83722977
92MP0003938_abnormal_ear_development0.82872917
93MP0003315_abnormal_perineum_morphology0.80999959
94MP0000579_abnormal_nail_morphology0.80368989
95MP0002090_abnormal_vision0.78162132
96MP0005195_abnormal_posterior_eye0.76683601
97MP0001346_abnormal_lacrimal_gland0.74098702
98MP0008260_abnormal_autophagy0.72300161
99MP0003137_abnormal_impulse_conducting0.71838382
100MP0001944_abnormal_pancreas_morphology0.69960788
101MP0000747_muscle_weakness0.69274207
102MP0003119_abnormal_digestive_system0.68054692
103MP0001765_abnormal_ion_homeostasis0.67986219
104MP0002069_abnormal_eating/drinking_beha0.66785229
105MP0000383_abnormal_hair_follicle0.66230968
106MP0004145_abnormal_muscle_electrophysio0.66152799
107MP0003656_abnormal_erythrocyte_physiolo0.65697514
108MP0005253_abnormal_eye_physiology0.65603219
109MP0002009_preneoplasia0.65388295
110MP0005084_abnormal_gallbladder_morpholo0.65315170
111MP0010769_abnormal_survival0.64601998
112MP0002082_postnatal_lethality0.63856130
113MP0010770_preweaning_lethality0.63856130
114MP0003868_abnormal_feces_composition0.63030228
115MP0000647_abnormal_sebaceous_gland0.62874933
116MP0003787_abnormal_imprinting0.62687763
117MP0001943_abnormal_respiration0.61753012
118MP0003861_abnormal_nervous_system0.61266554
119MP0005389_reproductive_system_phenotype0.60742233
120MP0010768_mortality/aging0.60697414
121MP0001664_abnormal_digestion0.59578702
122MP0004381_abnormal_hair_follicle0.59537702
123MP0002295_abnormal_pulmonary_circulatio0.59515097
124MP0000537_abnormal_urethra_morphology0.58820215
125MP0001661_extended_life_span0.58797203
126MP0006072_abnormal_retinal_apoptosis0.58442540
127MP0004085_abnormal_heartbeat0.57619364
128MP0003075_altered_response_to0.57058299
129MP0003879_abnormal_hair_cell0.56663084
130MP0008874_decreased_physiological_sensi0.56660483

Predicted human phenotypes

RankGene SetZ-score
1Ventricular fibrillation (HP:0001663)6.23116333
2Neurofibrillary tangles (HP:0002185)5.74679221
3Myokymia (HP:0002411)4.85036729
4Focal motor seizures (HP:0011153)4.71199621
5Supranuclear gaze palsy (HP:0000605)4.42881919
6Cerebral inclusion bodies (HP:0100314)4.32208652
7* Degeneration of the lateral corticospinal tracts (HP:0002314)3.97123020
8* Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.97123020
9Ankle clonus (HP:0011448)3.94013841
10Peripheral hypomyelination (HP:0007182)3.85575673
11Parakeratosis (HP:0001036)3.80112503
12Bronchomalacia (HP:0002780)3.76595446
13Epileptic encephalopathy (HP:0200134)3.68205047
14Sensory axonal neuropathy (HP:0003390)3.66575761
15Prolonged QT interval (HP:0001657)3.60457591
16Dysmetria (HP:0001310)3.48320751
17Focal seizures (HP:0007359)3.44251825
18* Abnormality of the corticospinal tract (HP:0002492)3.43790393
19* Spastic gait (HP:0002064)3.42068848
20Birth length less than 3rd percentile (HP:0003561)3.33027044
21Intention tremor (HP:0002080)3.26424533
22Onion bulb formation (HP:0003383)3.25587323
23Syncope (HP:0001279)3.22446543
24Akinesia (HP:0002304)3.22293981
25Action tremor (HP:0002345)3.12699610
26Retinal dysplasia (HP:0007973)3.08689346
27Atonic seizures (HP:0010819)3.06814023
28Pheochromocytoma (HP:0002666)3.03359087
29Scanning speech (HP:0002168)2.97235766
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.84867889
31Megalencephaly (HP:0001355)2.83572179
32Alacrima (HP:0000522)2.79185700
33Abnormality of the diencephalon (HP:0010662)2.78676977
34Aplasia involving bones of the extremities (HP:0009825)2.75095615
35Aplasia involving bones of the upper limbs (HP:0009823)2.75095615
36Aplasia of the phalanges of the hand (HP:0009802)2.75095615
37* Impaired vibration sensation in the lower limbs (HP:0002166)2.73657711
38Insomnia (HP:0100785)2.72649831
39* Urinary bladder sphincter dysfunction (HP:0002839)2.66991908
40Cerebral hypomyelination (HP:0006808)2.65434999
41Thickened helices (HP:0000391)2.65264116
42Macroorchidism (HP:0000053)2.62172244
43Hyperventilation (HP:0002883)2.61964190
44Broad-based gait (HP:0002136)2.61285906
45Slow saccadic eye movements (HP:0000514)2.59791399
46Neuroendocrine neoplasm (HP:0100634)2.59323414
47Abnormal auditory evoked potentials (HP:0006958)2.59019405
48Progressive cerebellar ataxia (HP:0002073)2.56006227
49* Urinary urgency (HP:0000012)2.46114865
50Status epilepticus (HP:0002133)2.42751053
51Absent septum pellucidum (HP:0001331)2.40510553
52Generalized tonic-clonic seizures (HP:0002069)2.40027340
53Anteriorly placed anus (HP:0001545)2.38904861
54EEG with generalized epileptiform discharges (HP:0011198)2.37285535
55Dysdiadochokinesis (HP:0002075)2.37075950
56Clumsiness (HP:0002312)2.32744143
57Gaze-evoked nystagmus (HP:0000640)2.31618908
58* Lower limb muscle weakness (HP:0007340)2.29965448
59Dialeptic seizures (HP:0011146)2.29729514
60Hypoplastic labia majora (HP:0000059)2.27720281
61Abnormal EKG (HP:0003115)2.25923043
62Febrile seizures (HP:0002373)2.25026223
63Hypsarrhythmia (HP:0002521)2.23668570
64Generalized myoclonic seizures (HP:0002123)2.23629126
65Leukodystrophy (HP:0002415)2.23191417
66Increased circulating renin level (HP:0000848)2.22674253
67Decreased lacrimation (HP:0000633)2.22531389
68Limb dystonia (HP:0002451)2.21440215
69Truncal ataxia (HP:0002078)2.17495583
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17408748
71Enlarged penis (HP:0000040)2.14748467
72Absence seizures (HP:0002121)2.12214258
73Progressive inability to walk (HP:0002505)2.11704422
74Visual hallucinations (HP:0002367)2.10723814
75Anxiety (HP:0000739)2.10285925
76Mutism (HP:0002300)2.09633701
77Cerebral hemorrhage (HP:0001342)2.09579773
78Split foot (HP:0001839)2.07705625
79Postural instability (HP:0002172)2.07455267
80* Morphological abnormality of the pyramidal tract (HP:0002062)2.06813792
81Hemiparesis (HP:0001269)2.06284244
82Torticollis (HP:0000473)2.06108781
83Neoplasm of the oral cavity (HP:0100649)2.04511795
84Spastic tetraparesis (HP:0001285)2.04460542
85Broad face (HP:0000283)2.04319298
86Abnormal eating behavior (HP:0100738)2.03748978
87Drooling (HP:0002307)2.02998881
88Excessive salivation (HP:0003781)2.02998881
89Abnormality of glycolysis (HP:0004366)2.02795389
90Increased serum pyruvate (HP:0003542)2.02795389
91Bowel incontinence (HP:0002607)2.00508437
92Tracheomalacia (HP:0002779)1.98320569
93Hyperacusis (HP:0010780)1.97778902
94Missing ribs (HP:0000921)1.97057867
95Coronal craniosynostosis (HP:0004440)1.96380188
96Type II lissencephaly (HP:0007260)1.96336860
97Steppage gait (HP:0003376)1.95185738
98Arthropathy (HP:0003040)1.94944422
99Abnormality of the septum pellucidum (HP:0007375)1.94813848
100Depression (HP:0000716)1.93278478
101Vaginal atresia (HP:0000148)1.91456011
102Blue irides (HP:0000635)1.91192875
103Impaired smooth pursuit (HP:0007772)1.91071389
104Absent speech (HP:0001344)1.91052737
105Dysmetric saccades (HP:0000641)1.90815144
106Morphological abnormality of the inner ear (HP:0011390)1.90619230
107* Insidious onset (HP:0003587)1.89831909
108* Termporal pattern (HP:0011008)1.89831909
109Partial agenesis of the corpus callosum (HP:0001338)1.89275900
110Hammertoe (HP:0001765)1.89220246
111Abnormality of the labia majora (HP:0012881)1.89093690
112Metabolic alkalosis (HP:0200114)1.88733567
113Gait imbalance (HP:0002141)1.88248242
114Papillary thyroid carcinoma (HP:0002895)1.88080461
115Abnormal large intestine physiology (HP:0012700)1.86804020
116Congenital ichthyosiform erythroderma (HP:0007431)1.86336105
117Decreased motor nerve conduction velocity (HP:0003431)1.86197463
118Annular pancreas (HP:0001734)1.85456912
119Genital tract atresia (HP:0001827)1.85289322
120Autoamputation (HP:0001218)1.84303084
121Synostosis involving the elbow (HP:0003938)1.84297479
122Humeroradial synostosis (HP:0003041)1.84297479
123Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84008375
124Abnormality of ocular smooth pursuit (HP:0000617)1.83959758
125Apathy (HP:0000741)1.83741951
126Elfin facies (HP:0004428)1.83659882
127Spastic tetraplegia (HP:0002510)1.83467344
128Poor eye contact (HP:0000817)1.83035883
129Attention deficit hyperactivity disorder (HP:0007018)1.81085021
130Diplopia (HP:0000651)1.80646685
131Abnormality of binocular vision (HP:0011514)1.80646685
132Sleep apnea (HP:0010535)1.80589693
133CNS hypomyelination (HP:0003429)1.80578805
134Abnormality of saccadic eye movements (HP:0000570)1.80375794
135Epileptiform EEG discharges (HP:0011182)1.80293442
136Relative macrocephaly (HP:0004482)1.79457341
137Neuronal loss in central nervous system (HP:0002529)1.79225654
138Labial hypoplasia (HP:0000066)1.75729705
139Testicular atrophy (HP:0000029)1.75611924
140Impaired social interactions (HP:0000735)1.74162032
141Abnormal social behavior (HP:0012433)1.74162032
142Postural tremor (HP:0002174)1.74068744
143Hepatoblastoma (HP:0002884)1.73266758
144Intellectual disability, profound (HP:0002187)1.73199069
145Breast hypoplasia (HP:0003187)1.71044633
146Gait ataxia (HP:0002066)1.70461327
147Diminished motivation (HP:0000745)1.69916570
148Urethral obstruction (HP:0000796)1.69644839
149Focal dystonia (HP:0004373)1.69030074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.56731713
2OXSR13.68304687
3MARK13.07638937
4TNIK2.64416202
5EPHA42.63939580
6CASK2.57273048
7EPHB12.52890076
8CDK192.44482021
9LATS22.36971393
10NTRK32.08669316
11PRPF4B2.05734504
12PKN11.98849688
13PAK61.94762099
14NTRK11.93620735
15TSSK61.86176312
16BCR1.81439021
17UHMK11.78800350
18MAPKAPK51.78412850
19WNK41.74818000
20WNK11.69327282
21PNCK1.68073844
22MAP3K91.67942489
23FGFR21.58206003
24MAP3K41.47384977
25NTRK21.47374980
26CAMK1D1.47113094
27MINK11.42747507
28NEK61.41343397
29SIK21.39437793
30CAMK2B1.38073943
31MAPK131.37397794
32CDK51.35468584
33SGK2231.34848632
34SGK4941.34848632
35MAP2K71.29887976
36SGK21.24684550
37PBK1.22245378
38PRKD31.22070315
39LIMK11.21671395
40PHKG11.20796134
41PHKG21.20796134
42CSNK1G21.19768054
43WEE11.18572900
44ROCK21.18462011
45CSNK1G31.18269189
46DAPK21.14542072
47DYRK21.12253760
48AKT31.11082881
49CSNK1A1L1.09870497
50CDK121.08145255
51CAMK2A1.06440680
52MET1.06214064
53EEF2K1.03994125
54CAMK2D1.02216561
55SGK31.00302207
56MUSK0.97968933
57PAK30.97819355
58MAPK150.96911260
59CDK140.96450378
60ARAF0.95957530
61PLK20.95101236
62CLK10.94660640
63TRIB30.94394341
64RIPK10.93763844
65FGR0.92727241
66LATS10.92383581
67CDK150.92299742
68MAP3K130.90357377
69CDK180.90028351
70CSNK1G10.88279632
71KSR20.87214929
72BRAF0.86436837
73MARK20.82536160
74GRK50.81973713
75CDK11A0.81697536
76PRKCE0.81170581
77TYRO30.81105555
78CAMK2G0.79123253
79IRAK20.78431124
80ALK0.78309340
81BRSK10.77828239
82PDGFRA0.77430385
83MST40.76263670
84STK110.71459117
85FES0.70369909
86MAP3K20.69969946
87PRKCQ0.69919992
88BMPR1B0.66983110
89PDPK10.64922243
90BMX0.64641952
91ICK0.63586818
92PRKCH0.63535224
93FYN0.62128304
94MST1R0.61696785
95PRKCG0.60653362
96STK380.59835154
97BMPR20.59557627
98YES10.57269150
99DYRK1A0.56537646
100PTK20.56181046
101RIPK40.53435694
102BRD40.52894412
103PRKD10.52764387
104SGK10.52708315
105RAF10.52700849
106MAP2K40.50951444
107CAMKK10.50581131
108RPS6KA30.48653831
109PINK10.48312443
110PDGFRB0.47477136
111CSNK1E0.47273656
112PRKG10.46418090
113PIK3CA0.46103384
114KSR10.45972690
115NEK90.45099827
116TESK20.44586384
117CAMK1G0.44456497
118EIF2AK10.44138920
119PDK10.44048239
120CSNK1D0.43462965
121INSRR0.41277594
122CAMKK20.41108321
123CAMK10.39702716
124PRKACB0.37951096
125RET0.37750655
126MAP2K10.37607182
127CAMK40.37557068
128SIK10.37126486
129CSNK1A10.36772697
130PAK20.33941655
131PRKACA0.33583314
132IRAK10.33439002
133PRKCZ0.32579369
134GSK3B0.31657025
135WNK30.30975574
136MAPK100.30840980

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.13023202
2Steroid biosynthesis_Homo sapiens_hsa001003.28481391
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85105395
4Fatty acid elongation_Homo sapiens_hsa000622.77589063
5Nicotine addiction_Homo sapiens_hsa050332.53864852
6GABAergic synapse_Homo sapiens_hsa047272.34856479
7Glutamatergic synapse_Homo sapiens_hsa047242.30248570
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15962666
9Ether lipid metabolism_Homo sapiens_hsa005652.14497219
10Morphine addiction_Homo sapiens_hsa050322.12144194
11Synaptic vesicle cycle_Homo sapiens_hsa047212.09361006
12Circadian entrainment_Homo sapiens_hsa047131.95334146
13Axon guidance_Homo sapiens_hsa043601.95309771
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85636132
15Serotonergic synapse_Homo sapiens_hsa047261.83409545
16Olfactory transduction_Homo sapiens_hsa047401.69710990
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68976328
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68576401
19Dopaminergic synapse_Homo sapiens_hsa047281.62122131
20Long-term depression_Homo sapiens_hsa047301.60559487
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60368474
22Salivary secretion_Homo sapiens_hsa049701.60063686
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57344982
24Long-term potentiation_Homo sapiens_hsa047201.52852161
25Amphetamine addiction_Homo sapiens_hsa050311.50224790
26Cholinergic synapse_Homo sapiens_hsa047251.47323022
27Cocaine addiction_Homo sapiens_hsa050301.46499351
28Gastric acid secretion_Homo sapiens_hsa049711.39531928
29Collecting duct acid secretion_Homo sapiens_hsa049661.33050086
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28219145
31Sphingolipid metabolism_Homo sapiens_hsa006001.23825898
32Taste transduction_Homo sapiens_hsa047421.23813493
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20713414
34Renin secretion_Homo sapiens_hsa049241.16489683
35Insulin secretion_Homo sapiens_hsa049111.15521768
36Butanoate metabolism_Homo sapiens_hsa006501.13130527
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11789980
38Oxidative phosphorylation_Homo sapiens_hsa001901.07998717
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07296127
40Hippo signaling pathway_Homo sapiens_hsa043901.05604410
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04979895
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04520426
43Gap junction_Homo sapiens_hsa045401.04095414
44Bile secretion_Homo sapiens_hsa049761.04037546
45Oxytocin signaling pathway_Homo sapiens_hsa049211.01502578
46Vibrio cholerae infection_Homo sapiens_hsa051101.00555201
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.00552934
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00319259
49ErbB signaling pathway_Homo sapiens_hsa040120.99550870
50Calcium signaling pathway_Homo sapiens_hsa040200.99425000
51Vitamin B6 metabolism_Homo sapiens_hsa007500.98733552
52Renal cell carcinoma_Homo sapiens_hsa052110.96946320
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.94402861
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94366890
55Alzheimers disease_Homo sapiens_hsa050100.94081848
56Phototransduction_Homo sapiens_hsa047440.93317468
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.93264441
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92676919
59Sulfur metabolism_Homo sapiens_hsa009200.90786175
60Oocyte meiosis_Homo sapiens_hsa041140.89666311
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87680503
62cAMP signaling pathway_Homo sapiens_hsa040240.87111496
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86225992
64Ras signaling pathway_Homo sapiens_hsa040140.85708277
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85670877
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.85025031
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83774966
68Cardiac muscle contraction_Homo sapiens_hsa042600.82845172
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82166129
70GnRH signaling pathway_Homo sapiens_hsa049120.79528978
71VEGF signaling pathway_Homo sapiens_hsa043700.78246612
72Nitrogen metabolism_Homo sapiens_hsa009100.78175858
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76581677
74Prolactin signaling pathway_Homo sapiens_hsa049170.76473954
75Parkinsons disease_Homo sapiens_hsa050120.74823458
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71879141
77Dorso-ventral axis formation_Homo sapiens_hsa043200.71326357
78Pancreatic secretion_Homo sapiens_hsa049720.70874462
79Tight junction_Homo sapiens_hsa045300.69955414
80Melanogenesis_Homo sapiens_hsa049160.69849729
81Endocytosis_Homo sapiens_hsa041440.69589910
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68984269
83Endometrial cancer_Homo sapiens_hsa052130.67420773
84Glucagon signaling pathway_Homo sapiens_hsa049220.65017441
85Linoleic acid metabolism_Homo sapiens_hsa005910.64858117
86Ovarian steroidogenesis_Homo sapiens_hsa049130.64685084
87Adherens junction_Homo sapiens_hsa045200.61568762
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60878335
89Choline metabolism in cancer_Homo sapiens_hsa052310.60365024
90Protein export_Homo sapiens_hsa030600.59235416
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58035819
92MAPK signaling pathway_Homo sapiens_hsa040100.57940188
93Rheumatoid arthritis_Homo sapiens_hsa053230.57685071
94Chronic myeloid leukemia_Homo sapiens_hsa052200.55478743
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55161777
96Colorectal cancer_Homo sapiens_hsa052100.53368039
97Alcoholism_Homo sapiens_hsa050340.51726576
98Estrogen signaling pathway_Homo sapiens_hsa049150.51059340
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50989092
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50744050
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.50192998
102MicroRNAs in cancer_Homo sapiens_hsa052060.48453847
103Basal cell carcinoma_Homo sapiens_hsa052170.48181178
104Fatty acid biosynthesis_Homo sapiens_hsa000610.47973710
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.47911267
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47778814
107Non-small cell lung cancer_Homo sapiens_hsa052230.47562172
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46555934
109Proteoglycans in cancer_Homo sapiens_hsa052050.45902142
110Insulin signaling pathway_Homo sapiens_hsa049100.45464738
111Dilated cardiomyopathy_Homo sapiens_hsa054140.44932351
112Type II diabetes mellitus_Homo sapiens_hsa049300.44422279
113Glioma_Homo sapiens_hsa052140.43040683
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42909975
115Phagosome_Homo sapiens_hsa041450.42606317
116mTOR signaling pathway_Homo sapiens_hsa041500.42214542
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41698684
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41432279
119Rap1 signaling pathway_Homo sapiens_hsa040150.41375067
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40619019
121beta-Alanine metabolism_Homo sapiens_hsa004100.39219841
122Circadian rhythm_Homo sapiens_hsa047100.38782438
123Arginine biosynthesis_Homo sapiens_hsa002200.38592851
124Thyroid hormone synthesis_Homo sapiens_hsa049180.38507621
125B cell receptor signaling pathway_Homo sapiens_hsa046620.38324868
126Prion diseases_Homo sapiens_hsa050200.37903799
127Histidine metabolism_Homo sapiens_hsa003400.37470177
128Mineral absorption_Homo sapiens_hsa049780.37421892
129Hedgehog signaling pathway_Homo sapiens_hsa043400.36864700
130Inositol phosphate metabolism_Homo sapiens_hsa005620.34105695
131Autoimmune thyroid disease_Homo sapiens_hsa053200.33302222
132Wnt signaling pathway_Homo sapiens_hsa043100.33013108

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