NINL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.01056406
2piRNA metabolic process (GO:0034587)4.92944693
3nuclear pore organization (GO:0006999)4.81532870
4microtubule depolymerization (GO:0007019)4.32225613
5pyrimidine nucleobase catabolic process (GO:0006208)4.29709133
6pore complex assembly (GO:0046931)4.02376276
7DNA replication-dependent nucleosome assembly (GO:0006335)3.97115856
8DNA replication-dependent nucleosome organization (GO:0034723)3.97115856
9synaptonemal complex assembly (GO:0007130)3.90181391
10cilium or flagellum-dependent cell motility (GO:0001539)3.80903731
11DNA methylation involved in gamete generation (GO:0043046)3.80734503
12male meiosis (GO:0007140)3.76921360
13paraxial mesoderm development (GO:0048339)3.73892407
14synaptonemal complex organization (GO:0070193)3.69695369
15heterochromatin organization (GO:0070828)3.60927928
16meiotic chromosome segregation (GO:0045132)3.59239890
17regulation of meiosis I (GO:0060631)3.59227142
18mitotic sister chromatid segregation (GO:0000070)3.56933562
19DNA replication initiation (GO:0006270)3.56132470
20kinetochore organization (GO:0051383)3.45886645
21chromosome organization involved in meiosis (GO:0070192)3.44520877
22sister chromatid segregation (GO:0000819)3.44243749
23regulation of centriole replication (GO:0046599)3.43956156
24presynaptic membrane assembly (GO:0097105)3.43440736
25DNA unwinding involved in DNA replication (GO:0006268)3.41475122
26mitotic sister chromatid cohesion (GO:0007064)3.39172682
27mitotic metaphase plate congression (GO:0007080)3.37858839
28protein K6-linked ubiquitination (GO:0085020)3.37769469
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35291269
30DNA replication checkpoint (GO:0000076)3.34762810
31regulation of posttranscriptional gene silencing (GO:0060147)3.30078825
32regulation of gene silencing by miRNA (GO:0060964)3.30078825
33regulation of gene silencing by RNA (GO:0060966)3.30078825
34regulation of histone H3-K9 methylation (GO:0051570)3.28124564
35gonadal mesoderm development (GO:0007506)3.27123700
36protein localization to kinetochore (GO:0034501)3.26620168
37nucleobase catabolic process (GO:0046113)3.23052160
38limb bud formation (GO:0060174)3.20296443
39positive regulation of male gonad development (GO:2000020)3.19544903
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.17245036
41chromatin assembly (GO:0031497)3.16338512
42gene silencing by RNA (GO:0031047)3.12333741
43chromatin remodeling at centromere (GO:0031055)3.12000154
44mitotic nuclear envelope disassembly (GO:0007077)3.11073879
45mitotic chromosome condensation (GO:0007076)3.09770420
46presynaptic membrane organization (GO:0097090)3.09746170
47metaphase plate congression (GO:0051310)3.07280985
48regulation of sister chromatid cohesion (GO:0007063)3.07058482
49meiotic nuclear division (GO:0007126)3.05832871
50protein localization to chromosome, centromeric region (GO:0071459)3.04663123
51kinetochore assembly (GO:0051382)3.03730660
52regulation of centrosome cycle (GO:0046605)3.02472323
53negative regulation of chromosome segregation (GO:0051985)3.01537435
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.01356740
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01356740
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01356740
57DNA strand elongation involved in DNA replication (GO:0006271)3.00332596
58cell migration in hindbrain (GO:0021535)2.99729931
59embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98875738
60histone H2A acetylation (GO:0043968)2.98435030
61regulation of chromosome segregation (GO:0051983)2.97531467
62regulation of DNA endoreduplication (GO:0032875)2.95066350
63negative regulation of DNA repair (GO:0045738)2.95002284
64histone exchange (GO:0043486)2.94766394
65convergent extension (GO:0060026)2.94455552
66pre-miRNA processing (GO:0031054)2.94439829
67DNA replication-independent nucleosome organization (GO:0034724)2.93603136
68DNA replication-independent nucleosome assembly (GO:0006336)2.93603136
69regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93134944
70DNA double-strand break processing (GO:0000729)2.92549933
71DNA strand elongation (GO:0022616)2.92385128
72negative regulation of sister chromatid segregation (GO:0033046)2.92033213
73negative regulation of mitotic sister chromatid separation (GO:2000816)2.92033213
74negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92033213
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92033213
76DNA duplex unwinding (GO:0032508)2.91134256
77DNA geometric change (GO:0032392)2.90371662
78regulation of chromatin binding (GO:0035561)2.90273144
79regulation of double-strand break repair (GO:2000779)2.89705459
80regulation of male gonad development (GO:2000018)2.88656500
81membrane disassembly (GO:0030397)2.88208707
82nuclear envelope disassembly (GO:0051081)2.88208707
83dorsal/ventral axis specification (GO:0009950)2.88135609
84postsynaptic membrane organization (GO:0001941)2.87809858
85regulation of sister chromatid segregation (GO:0033045)2.87437885
86regulation of mitotic sister chromatid separation (GO:0010965)2.87437885
87regulation of mitotic sister chromatid segregation (GO:0033047)2.87437885
88axonal fasciculation (GO:0007413)2.86855074
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86590205
90neuron recognition (GO:0008038)2.86268576
91regulation of helicase activity (GO:0051095)2.86061784
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85586133
93G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85562700
94DNA methylation (GO:0006306)2.85328162
95DNA alkylation (GO:0006305)2.85328162
96CENP-A containing nucleosome assembly (GO:0034080)2.85171204
97spindle assembly checkpoint (GO:0071173)2.84109376
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82296568
99intra-S DNA damage checkpoint (GO:0031573)2.82156376
100attachment of spindle microtubules to kinetochore (GO:0008608)2.82098944
101spindle checkpoint (GO:0031577)2.80663221
102mitotic spindle assembly checkpoint (GO:0007094)2.80468812
103positive regulation of chromosome segregation (GO:0051984)2.80420911
104regulation of centrosome duplication (GO:0010824)2.79990775
105mitotic spindle checkpoint (GO:0071174)2.78750599
106chromatin assembly or disassembly (GO:0006333)2.76709869
107axonemal dynein complex assembly (GO:0070286)2.76460636
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.76368499
109notochord development (GO:0030903)2.73344517
110chromosome segregation (GO:0007059)2.71559593
111spinal cord development (GO:0021510)2.70885753
112meiotic cell cycle process (GO:1903046)2.70736603
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70426332
114mitotic recombination (GO:0006312)2.70098087
115regulation of double-strand break repair via homologous recombination (GO:0010569)2.70093033
116lateral sprouting from an epithelium (GO:0060601)2.68330428
117regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67911774
118short-term memory (GO:0007614)2.67864470
119vocalization behavior (GO:0071625)2.63894456
120neuronal stem cell maintenance (GO:0097150)2.62056595
121L-serine metabolic process (GO:0006563)2.59936432
122calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58950420
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.57247108
124axon extension involved in axon guidance (GO:0048846)2.57247108
125neurotransmitter-gated ion channel clustering (GO:0072578)2.56641138
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56596994
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54918580
128nonmotile primary cilium assembly (GO:0035058)2.53253144
129regulation of development, heterochronic (GO:0040034)2.49201564
130body morphogenesis (GO:0010171)2.48741951
131lung-associated mesenchyme development (GO:0060484)2.47475345
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.46881227
133establishment of monopolar cell polarity (GO:0061162)2.46881227
134neuron cell-cell adhesion (GO:0007158)2.46537672
135olfactory bulb development (GO:0021772)2.46376373
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.43739254
137regulation of translation, ncRNA-mediated (GO:0045974)2.43739254
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43739254
139establishment of mitochondrion localization (GO:0051654)2.43602753
140protein localization to synapse (GO:0035418)2.43223344
141synapse assembly (GO:0007416)2.40798654
142apical protein localization (GO:0045176)2.36973587
143somite development (GO:0061053)2.36521266
144ectodermal placode formation (GO:0060788)2.35194128
145positive regulation of dendritic spine morphogenesis (GO:0061003)2.34290613
146layer formation in cerebral cortex (GO:0021819)2.34008131
147retinal ganglion cell axon guidance (GO:0031290)2.32532265
148mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.31875775
149kidney morphogenesis (GO:0060993)2.31291393
150regulation of growth hormone secretion (GO:0060123)2.30795323
151establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.30209732
152regulation of timing of cell differentiation (GO:0048505)2.30025846
153gastrulation with mouth forming second (GO:0001702)2.29126512
154regulation of cell fate specification (GO:0042659)2.28493890
155forebrain neuron differentiation (GO:0021879)2.26518154
156ganglion development (GO:0061548)2.24799862
157cerebral cortex radially oriented cell migration (GO:0021799)2.23962501
158embryonic foregut morphogenesis (GO:0048617)2.21245454
159cell proliferation in forebrain (GO:0021846)2.18268704
160cardiac right ventricle morphogenesis (GO:0003215)2.18053060
161ephrin receptor signaling pathway (GO:0048013)2.15409448
162negative chemotaxis (GO:0050919)2.15356253
163establishment of tissue polarity (GO:0007164)2.14131844
164establishment of planar polarity (GO:0001736)2.14131844
165intraciliary transport (GO:0042073)2.13955140
166protein-DNA complex disassembly (GO:0032986)2.13386951
167nucleosome disassembly (GO:0006337)2.13386951
168axon extension (GO:0048675)2.13076906
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12924772
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.12675711
171establishment of nucleus localization (GO:0040023)2.12496426
172head development (GO:0060322)2.10942243
173negative regulation of axon guidance (GO:1902668)2.10099708
174camera-type eye morphogenesis (GO:0048593)2.09620422
175generation of neurons (GO:0048699)2.08014724
176regulation of hippo signaling (GO:0035330)2.07730523
177positive regulation of neuroblast proliferation (GO:0002052)2.07433778
178lung epithelium development (GO:0060428)2.07293038
179mesenchymal to epithelial transition (GO:0060231)2.07192809
180hindbrain development (GO:0030902)2.05998049
181hippocampus development (GO:0021766)2.05829823
182regulation of establishment of planar polarity (GO:0090175)2.05747107
183inner ear receptor cell development (GO:0060119)2.02909155
184anterior/posterior axis specification (GO:0009948)2.01611009
185establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.01111930
186mitochondrion transport along microtubule (GO:0047497)2.01111930
187central nervous system projection neuron axonogenesis (GO:0021952)2.01015470
188regulation of neuron migration (GO:2001222)1.99759747
189post-anal tail morphogenesis (GO:0036342)1.98758925
190negative regulation of glial cell differentiation (GO:0045686)1.98546158
191negative regulation of axon extension involved in axon guidance (GO:0048843)1.98224989
192establishment of apical/basal cell polarity (GO:0035089)1.97222799
193dendrite morphogenesis (GO:0048813)1.97091907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.90287936
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.06657658
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.57989134
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34068450
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.48575026
6EZH2_22144423_ChIP-Seq_EOC_Human3.39713828
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.15682066
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.08189301
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.92090380
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86767242
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.75587846
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.75587846
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.75587846
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55220726
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50867513
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.40829151
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29679806
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.28329871
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26151586
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.21478139
21SOX2_18555785_ChIP-Seq_MESCs_Mouse2.19145908
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.17215678
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11483606
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10717647
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10055386
26GBX2_23144817_ChIP-Seq_PC3_Human2.05659528
27AR_21909140_ChIP-Seq_LNCAP_Human2.02214532
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99886317
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91802138
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.88350732
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87065038
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86574225
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82109318
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81742996
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.80663877
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78641913
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75529337
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74364119
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70274889
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.67003599
41TTF2_22483619_ChIP-Seq_HELA_Human1.65155615
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.64006396
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62622741
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60388059
45XRN2_22483619_ChIP-Seq_HELA_Human1.59150331
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58414917
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56924010
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56924010
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.56708392
50ZNF274_21170338_ChIP-Seq_K562_Hela1.54872742
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53781159
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52748322
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51457730
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51289202
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49990586
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47481262
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46512306
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45018874
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43309800
60DCP1A_22483619_ChIP-Seq_HELA_Human1.42270530
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.41458580
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41319691
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39552281
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39161543
65TAF15_26573619_Chip-Seq_HEK293_Human1.38653289
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.38149247
67REST_21632747_ChIP-Seq_MESCs_Mouse1.36736139
68TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35494968
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.35268226
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.34123450
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33570861
72FUS_26573619_Chip-Seq_HEK293_Human1.33467756
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33085641
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32091379
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.31906348
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31026287
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30425508
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29782532
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29185546
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.29116116
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.29014706
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27408135
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.26936063
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.26322324
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25481283
86ELK1_19687146_ChIP-ChIP_HELA_Human1.25465761
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24832875
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23507439
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23368491
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22833277
91VDR_23849224_ChIP-Seq_CD4+_Human1.22703961
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22078567
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20917518
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20746120
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20367666
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20367666
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.20127603
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.19968570
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19965811
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19646185
101P300_19829295_ChIP-Seq_ESCs_Human1.19191257
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19018360
103FOXP3_21729870_ChIP-Seq_TREG_Human1.18292114
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.18279131
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17955003
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17927924
107THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17546765
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17525963
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.17147416
110IGF1R_20145208_ChIP-Seq_DFB_Human1.17085056
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16496647
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16147429
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15479024
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.15457575
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15192606
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15126582
117SOX9_26525672_Chip-Seq_HEART_Mouse1.14937258
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14811159
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.14662049
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13276549
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12150371
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11193711
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10544834
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10509392
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10353339
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.09667444
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08712756
128ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08453137
129ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08288836
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07767228
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07508798
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05573007
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04967759
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04733374
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04645947
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04359313
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04097538
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03976117
139SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03260772
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02411397
141ERG_21242973_ChIP-ChIP_JURKAT_Human1.02103574
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01724026
143KDM5A_27292631_Chip-Seq_BREAST_Human1.01419866
144POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01144836
145GABP_17652178_ChIP-ChIP_JURKAT_Human1.00904073
146AR_21572438_ChIP-Seq_LNCaP_Human1.00391798
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00229012
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00036260
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99652206
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99071699
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98802799
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.97760352
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97456052
154TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96125938
155SMAD4_21799915_ChIP-Seq_A2780_Human0.95719784
156IRF1_19129219_ChIP-ChIP_H3396_Human0.95553994
157GABP_19822575_ChIP-Seq_HepG2_Human0.95268410
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94730140
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92866496
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.92614614
161POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92385175
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91469535
163CIITA_25753668_ChIP-Seq_RAJI_Human0.88670157
164CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87271834
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84284963
166POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83832129
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82499259
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79831748
169* RNF2_27304074_Chip-Seq_NSC_Mouse0.79122022
170NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78409918
171FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75194794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.82564658
2MP0003122_maternal_imprinting3.52701404
3MP0003111_abnormal_nucleus_morphology3.46230494
4MP0010094_abnormal_chromosome_stability3.38231964
5MP0008057_abnormal_DNA_replication3.36846482
6MP0003693_abnormal_embryo_hatching2.89051322
7MP0002653_abnormal_ependyma_morphology2.86146982
8MP0008058_abnormal_DNA_repair2.64495793
9MP0004957_abnormal_blastocyst_morpholog2.58821249
10MP0003077_abnormal_cell_cycle2.57152107
11MP0010030_abnormal_orbit_morphology2.47449631
12MP0000778_abnormal_nervous_system2.18933167
13MP0003123_paternal_imprinting2.18265480
14MP0002210_abnormal_sex_determination2.10352298
15MP0003786_premature_aging2.08750428
16MP0008932_abnormal_embryonic_tissue2.07739788
17MP0005410_abnormal_fertilization2.04728489
18MP0008007_abnormal_cellular_replicative2.00204154
19MP0008995_early_reproductive_senescence1.99983759
20MP0005377_hearing/vestibular/ear_phenot1.92906376
21MP0003878_abnormal_ear_physiology1.92906376
22MP0003121_genomic_imprinting1.84330327
23MP0001929_abnormal_gametogenesis1.80348147
24MP0001145_abnormal_male_reproductive1.77480448
25MP0002102_abnormal_ear_morphology1.74804311
26MP0010307_abnormal_tumor_latency1.71539726
27MP0003941_abnormal_skin_development1.71320642
28MP0001293_anophthalmia1.67410395
29MP0003315_abnormal_perineum_morphology1.66338310
30MP0001299_abnormal_eye_distance/1.66127504
31MP0003890_abnormal_embryonic-extraembry1.62503183
32MP0004270_analgesia1.60082082
33MP0001529_abnormal_vocalization1.59091765
34MP0003698_abnormal_male_reproductive1.58403705
35MP0004197_abnormal_fetal_growth/weight/1.54710169
36MP0000350_abnormal_cell_proliferation1.54471901
37MP0006292_abnormal_olfactory_placode1.54432955
38MP0000537_abnormal_urethra_morphology1.54341979
39MP0003136_yellow_coat_color1.53134076
40MP0002085_abnormal_embryonic_tissue1.52334112
41MP0010352_gastrointestinal_tract_polyps1.52018594
42MP0000653_abnormal_sex_gland1.51374664
43MP0003880_abnormal_central_pattern1.51068688
44MP0005076_abnormal_cell_differentiation1.48983485
45MP0002084_abnormal_developmental_patter1.48658214
46MP0001984_abnormal_olfaction1.48395710
47MP0001730_embryonic_growth_arrest1.48286707
48MP0003787_abnormal_imprinting1.44214581
49MP0003119_abnormal_digestive_system1.44155881
50MP0003937_abnormal_limbs/digits/tail_de1.42578522
51MP0004133_heterotaxia1.40667396
52MP0005257_abnormal_intraocular_pressure1.40657304
53MP0000049_abnormal_middle_ear1.40614077
54MP0004859_abnormal_synaptic_plasticity1.39164184
55MP0001672_abnormal_embryogenesis/_devel1.38440081
56MP0005380_embryogenesis_phenotype1.38440081
57MP0002160_abnormal_reproductive_system1.38185788
58MP0008789_abnormal_olfactory_epithelium1.37462266
59MP0005623_abnormal_meninges_morphology1.34119136
60MP0006276_abnormal_autonomic_nervous1.31540752
61MP0000955_abnormal_spinal_cord1.31073011
62MP0000631_abnormal_neuroendocrine_gland1.27450227
63MP0002184_abnormal_innervation1.26813760
64MP0000432_abnormal_head_morphology1.26156104
65MP0001697_abnormal_embryo_size1.24104620
66MP0002938_white_spotting1.23952822
67MP0000428_abnormal_craniofacial_morphol1.22137631
68MP0003942_abnormal_urinary_system1.22080924
69MP0004272_abnormal_basement_membrane1.19664128
70MP0003385_abnormal_body_wall1.19574462
71MP0002282_abnormal_trachea_morphology1.18640833
72MP0003755_abnormal_palate_morphology1.17570236
73MP0002088_abnormal_embryonic_growth/wei1.16051025
74MP0003984_embryonic_growth_retardation1.15987378
75MP0002249_abnormal_larynx_morphology1.15447148
76MP0000534_abnormal_ureter_morphology1.15067149
77MP0000566_synostosis1.15036141
78MP0002751_abnormal_autonomic_nervous1.14712430
79MP0001188_hyperpigmentation1.14339516
80MP0005394_taste/olfaction_phenotype1.14300355
81MP0005499_abnormal_olfactory_system1.14300355
82MP0001286_abnormal_eye_development1.12756835
83MP0002086_abnormal_extraembryonic_tissu1.12337846
84MP0002233_abnormal_nose_morphology1.11565816
85MP0002638_abnormal_pupillary_reflex1.10074747
86MP0002092_abnormal_eye_morphology1.09731303
87MP0002557_abnormal_social/conspecific_i1.09020117
88MP0002152_abnormal_brain_morphology1.08976353
89MP0002734_abnormal_mechanical_nocicepti1.08588785
90MP0003861_abnormal_nervous_system1.08212504
91MP0002116_abnormal_craniofacial_bone1.07688816
92MP0009703_decreased_birth_body1.05201847
93MP0009384_cardiac_valve_regurgitation1.03945244
94MP0003115_abnormal_respiratory_system1.03671027
95MP0000569_abnormal_digit_pigmentation1.03358801
96MP0002080_prenatal_lethality1.02946204
97MP0002697_abnormal_eye_size1.02239520
98MP0002111_abnormal_tail_morphology1.01509972
99MP0009672_abnormal_birth_weight1.00357829
100MP0002822_catalepsy1.00301998
101MP0002234_abnormal_pharynx_morphology1.00003836
102MP0003935_abnormal_craniofacial_develop0.99547884
103MP0005171_absent_coat_pigmentation0.98578176
104MP0005389_reproductive_system_phenotype0.98137073
105MP0002161_abnormal_fertility/fecundity0.97960516
106MP0004233_abnormal_muscle_weight0.97699227
107MP0002909_abnormal_adrenal_gland0.97290896
108MP0002752_abnormal_somatic_nervous0.97177090
109MP0005248_abnormal_Harderian_gland0.97060973
110MP0003936_abnormal_reproductive_system0.96674291
111MP0000579_abnormal_nail_morphology0.95933815
112MP0005391_vision/eye_phenotype0.95866524
113MP0005187_abnormal_penis_morphology0.93079992
114MP0001119_abnormal_female_reproductive0.92671827
115MP0001915_intracranial_hemorrhage0.92554657
116MP0001727_abnormal_embryo_implantation0.91917149
117MP0003938_abnormal_ear_development0.91523690
118MP0003283_abnormal_digestive_organ0.91485128
119MP0009053_abnormal_anal_canal0.91109233
120MP0002882_abnormal_neuron_morphology0.90484470
121MP0002114_abnormal_axial_skeleton0.89895515
122MP0009278_abnormal_bone_marrow0.88293425
123MP0002081_perinatal_lethality0.87631161
124MP0000313_abnormal_cell_death0.87622587
125MP0000026_abnormal_inner_ear0.87447255
126MP0009250_abnormal_appendicular_skeleto0.87023949
127MP0000516_abnormal_urinary_system0.85872636
128MP0005367_renal/urinary_system_phenotyp0.85872636
129MP0003567_abnormal_fetal_cardiomyocyte0.85030466
130MP0005195_abnormal_posterior_eye0.83199989
131MP0006072_abnormal_retinal_apoptosis0.82191890
132MP0000490_abnormal_crypts_of0.82189804
133MP0002089_abnormal_postnatal_growth/wei0.81522641
134MP0002932_abnormal_joint_morphology0.81466368
135MP0002736_abnormal_nociception_after0.80157203
136MP0005423_abnormal_somatic_nervous0.79979653
137MP0003635_abnormal_synaptic_transmissio0.79214443
138MP0004811_abnormal_neuron_physiology0.78925071
139MP0005503_abnormal_tendon_morphology0.78418571
140MP0003718_maternal_effect0.75444478
141MP0002063_abnormal_learning/memory/cond0.74344267
142MP0000762_abnormal_tongue_morphology0.73922968
143MP0002572_abnormal_emotion/affect_behav0.71927247
144MP0002735_abnormal_chemical_nociception0.69865454
145MP0001270_distended_abdomen0.69060686
146MP0001346_abnormal_lacrimal_gland0.68897775
147MP0002109_abnormal_limb_morphology0.68520625

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12583440
2Chromsome breakage (HP:0040012)3.86492221
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.71348988
4Hepatoblastoma (HP:0002884)3.42182087
5Meckel diverticulum (HP:0002245)3.12586351
6Abnormality of the ileum (HP:0001549)3.05539517
7Supernumerary spleens (HP:0009799)2.93551409
8Selective tooth agenesis (HP:0001592)2.90675171
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.90169438
10Medulloblastoma (HP:0002885)2.82542979
11Abnormality of chromosome stability (HP:0003220)2.74258160
12Anophthalmia (HP:0000528)2.70774288
13Nephroblastoma (Wilms tumor) (HP:0002667)2.70699286
14Ectopic kidney (HP:0000086)2.64373395
15Septo-optic dysplasia (HP:0100842)2.63187636
16Impulsivity (HP:0100710)2.59685635
17Embryonal renal neoplasm (HP:0011794)2.59601470
18Absent/shortened dynein arms (HP:0200106)2.59590370
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.59590370
20Bifid tongue (HP:0010297)2.58551194
21Abnormality of the preputium (HP:0100587)2.57306703
2211 pairs of ribs (HP:0000878)2.51958549
23Cutaneous finger syndactyly (HP:0010554)2.50554580
24High anterior hairline (HP:0009890)2.49031065
25Supernumerary ribs (HP:0005815)2.43770840
26Patellar aplasia (HP:0006443)2.42507223
27Small intestinal stenosis (HP:0012848)2.40228209
28Duodenal stenosis (HP:0100867)2.40228209
29Absent radius (HP:0003974)2.40104008
30Facial cleft (HP:0002006)2.37874988
31Vitreoretinal degeneration (HP:0000655)2.36644541
32Birth length less than 3rd percentile (HP:0003561)2.36460326
33Supernumerary bones of the axial skeleton (HP:0009144)2.35470242
34Cutaneous syndactyly (HP:0012725)2.34439099
35Renal hypoplasia (HP:0000089)2.33259648
36Abnormal respiratory motile cilium physiology (HP:0012261)2.32994906
37Abnormal respiratory motile cilium morphology (HP:0005938)2.31845828
38Abnormal respiratory epithelium morphology (HP:0012253)2.31845828
39Absent forearm bone (HP:0003953)2.31242732
40Aplasia involving forearm bones (HP:0009822)2.31242732
41Ependymoma (HP:0002888)2.31206815
42Abnormal number of incisors (HP:0011064)2.30630298
43Missing ribs (HP:0000921)2.29435294
44Abnormality of the labia minora (HP:0012880)2.29343893
45Abnormal sex determination (HP:0012244)2.28172176
46Sex reversal (HP:0012245)2.28172176
47Abnormality of the carotid arteries (HP:0005344)2.27448567
48Volvulus (HP:0002580)2.26808799
49Aplasia/Hypoplasia of the patella (HP:0006498)2.25981176
50Myelomeningocele (HP:0002475)2.24506803
51Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22318285
52Short 4th metacarpal (HP:0010044)2.22318285
53Abnormality of the aortic arch (HP:0012303)2.20182281
54Glioma (HP:0009733)2.18177220
55Increased nuchal translucency (HP:0010880)2.17450082
56Absent thumb (HP:0009777)2.17179632
57Short thumb (HP:0009778)2.16383101
58Broad alveolar ridges (HP:0000187)2.15493617
59Abnormal lung lobation (HP:0002101)2.15357907
60Hyperglycinemia (HP:0002154)2.13597701
61Genital tract atresia (HP:0001827)2.13000783
62Nephronophthisis (HP:0000090)2.12620233
63Astrocytoma (HP:0009592)2.12353318
64Abnormality of the astrocytes (HP:0100707)2.12353318
65Morphological abnormality of the middle ear (HP:0008609)2.11105900
66Trigonocephaly (HP:0000243)2.10157134
67Breast hypoplasia (HP:0003187)2.09901952
68Vaginal atresia (HP:0000148)2.08750704
69Midline defect of the nose (HP:0004122)2.08325141
70Bilateral microphthalmos (HP:0007633)2.06082659
71Rhabdomyosarcoma (HP:0002859)2.05933642
72Absent eyebrow (HP:0002223)2.00594591
73Preaxial foot polydactyly (HP:0001841)2.00502594
74Gonadotropin excess (HP:0000837)2.00071586
75Tubulointerstitial nephritis (HP:0001970)1.99834108
76Cortical dysplasia (HP:0002539)1.99390633
77Drooling (HP:0002307)1.99086984
78Proximal placement of thumb (HP:0009623)1.97159491
79Choanal stenosis (HP:0000452)1.96873897
80Abnormality of the duodenum (HP:0002246)1.96043081
81Short ribs (HP:0000773)1.95639949
82Fibular hypoplasia (HP:0003038)1.95573880
83Neoplasm of the oral cavity (HP:0100649)1.95323117
84Bicornuate uterus (HP:0000813)1.95129672
85Sloping forehead (HP:0000340)1.94951839
86Broad thumb (HP:0011304)1.94042653
87Duplicated collecting system (HP:0000081)1.93655399
88Neoplasm of striated muscle (HP:0009728)1.93451736
89Optic nerve hypoplasia (HP:0000609)1.92491645
90Abnormality of the anterior horn cell (HP:0006802)1.92169795
91Degeneration of anterior horn cells (HP:0002398)1.92169795
92Deviation of the thumb (HP:0009603)1.90717881
93Abnormal ciliary motility (HP:0012262)1.90546041
94Abnormality of the pubic bones (HP:0003172)1.90493375
95Hemivertebrae (HP:0002937)1.89091350
96Partial duplication of thumb phalanx (HP:0009944)1.88292262
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.87787727
98Male pseudohermaphroditism (HP:0000037)1.87740763
99Reticulocytopenia (HP:0001896)1.87277128
100Abnormality of the renal medulla (HP:0100957)1.86522586
101Colon cancer (HP:0003003)1.86161902
102Rib fusion (HP:0000902)1.83816247
103Hypoplastic pelvis (HP:0008839)1.83424687
104Renal duplication (HP:0000075)1.83281379
105Triphalangeal thumb (HP:0001199)1.82043866
106Atresia of the external auditory canal (HP:0000413)1.81784081
107Rhinitis (HP:0012384)1.80159347
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79347637
109Abnormality of the lower motor neuron (HP:0002366)1.79305308
110Abnormality of cochlea (HP:0000375)1.78688221
111Bronchomalacia (HP:0002780)1.78585819
112Facial hemangioma (HP:0000329)1.77752044
113Absent epiphyses (HP:0010577)1.76270640
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76270640
115Absent septum pellucidum (HP:0001331)1.75365986
116Broad phalanges of the hand (HP:0009768)1.75195268
117Esophageal atresia (HP:0002032)1.74908925
118Vertebral arch anomaly (HP:0008438)1.74814668
119Abnormality of the phalanges of the hallux (HP:0010057)1.74708968
120Occipital encephalocele (HP:0002085)1.74416895
121Tracheoesophageal fistula (HP:0002575)1.74228419
122Coronal craniosynostosis (HP:0004440)1.74043139
123Shawl scrotum (HP:0000049)1.73931275
124Clubbing of toes (HP:0100760)1.72991097
125Broad finger (HP:0001500)1.72865476
126Micropenis (HP:0000054)1.72430691
127Aplasia/hypoplasia of the humerus (HP:0006507)1.71800772
128Severe Myopia (HP:0011003)1.70165860
129Cupped ear (HP:0000378)1.69251761
130Alacrima (HP:0000522)1.68930759
131Labial hypoplasia (HP:0000066)1.68807579
132Myelodysplasia (HP:0002863)1.68151144
133Spinal muscular atrophy (HP:0007269)1.68062814
134Abnormality of the antihelix (HP:0009738)1.67384938
135Abnormal spermatogenesis (HP:0008669)1.66997146
136Skull defect (HP:0001362)1.66585894
137Excessive salivation (HP:0003781)1.66566402
138Omphalocele (HP:0001539)1.66490354
139Oligodactyly (HP:0012165)1.66270118
140Renal dysplasia (HP:0000110)1.66085257
141Aplasia/Hypoplasia of the fibula (HP:0006492)1.65983754
142Median cleft lip (HP:0000161)1.65900902
143Diastasis recti (HP:0001540)1.64962209
144Partial duplication of the phalanx of hand (HP:0009999)1.64928005
145Abnormality of the renal collecting system (HP:0004742)1.64918774
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64452204
147Neonatal short-limb short stature (HP:0008921)1.63219764
148Abdominal situs inversus (HP:0003363)1.62920498
149Abnormality of abdominal situs (HP:0011620)1.62920498
150Azoospermia (HP:0000027)1.62681088
151Gastrointestinal atresia (HP:0002589)1.62298981
152Duplication of thumb phalanx (HP:0009942)1.62152893
153Chronic hepatic failure (HP:0100626)1.62019197
154Intestinal atresia (HP:0011100)1.61807130
155Hypochromic microcytic anemia (HP:0004840)1.61566972
156Morphological abnormality of the inner ear (HP:0011390)1.60926179
157Broad phalanx (HP:0006009)1.60620627
158Short humerus (HP:0005792)1.60551187
159Preaxial hand polydactyly (HP:0001177)1.60524474
160Abnormality of dentin (HP:0010299)1.60524437
161Broad palm (HP:0001169)1.60257383
162Gait imbalance (HP:0002141)1.60245706
163Chronic bronchitis (HP:0004469)1.59425009
164Broad long bones (HP:0005622)1.57943087
165Aqueductal stenosis (HP:0002410)1.56543933
166Hypoplastic female external genitalia (HP:0012815)1.56224329
167Meningocele (HP:0002435)1.54825138
168Scrotal hypoplasia (HP:0000046)1.54743950
169Shallow orbits (HP:0000586)1.54045078
170Abnormality of the septum pellucidum (HP:0007375)1.53999430
171Aplasia involving bones of the extremities (HP:0009825)1.51863579
172Aplasia involving bones of the upper limbs (HP:0009823)1.51863579
173Aplasia of the phalanges of the hand (HP:0009802)1.51863579
174Aplasia/Hypoplasia of the brainstem (HP:0007362)1.50356915
175Hypoplasia of the brainstem (HP:0002365)1.50356915
176Abnormality of the ischium (HP:0003174)1.50348793
177Bifid scrotum (HP:0000048)1.48718246
178Mixed hearing impairment (HP:0000410)1.48630207
179Dandy-Walker malformation (HP:0001305)1.47570125
180Breast aplasia (HP:0100783)1.47002864
181Aplasia/Hypoplasia of the breasts (HP:0010311)1.46348176
182Abnormality of the intervertebral disk (HP:0005108)1.46156542
183Turricephaly (HP:0000262)1.46041493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.20306349
2CDK124.18228420
3PASK3.89573124
4NEK23.05619617
5CASK3.03945158
6SRPK12.91141483
7MARK12.75793004
8WEE12.71480951
9TTK2.55419777
10FGFR22.52750694
11EPHA42.44235751
12TNIK2.41314482
13BRD42.41208696
14NTRK22.28215833
15MKNK22.18719816
16MAP3K42.17427347
17BCR2.17402645
18PLK42.10091945
19DYRK22.07820169
20PDK42.05680442
21PDK32.05680442
22NTRK11.97118772
23CDK71.96279816
24STK38L1.94529315
25MKNK11.93178803
26* PLK11.91442522
27ICK1.90433285
28LATS11.87037944
29EPHA21.81004228
30MAP2K71.79383648
31ATR1.78608219
32TLK11.78146795
33EIF2AK11.77734906
34BUB11.72197799
35WNK31.70682560
36CHEK21.68701850
37TAF11.66854779
38PLK31.63393811
39NEK11.56991185
40ERBB31.55779561
41PDK21.51714813
42TRIM281.50604388
43ZAK1.50355275
44CHEK11.49113898
45CAMK1G1.38249278
46PNCK1.29662272
47BRSK21.28957851
48PKN21.25996532
49CSNK1G21.23661890
50STK31.22995959
51CDK41.22950540
52* AURKB1.21072346
53ATM1.20712102
54CSNK1G11.18062638
55PAK41.14198241
56CSNK1A1L1.12370288
57DYRK31.07099588
58CSNK1G31.06300633
59TYRO31.05271613
60DYRK1B1.04668092
61MAPK131.03817119
62AKT31.02856339
63STK41.01667795
64YES11.00976504
65MINK11.00964751
66CDK90.99684411
67SGK2230.99365775
68SGK4940.99365775
69CDK190.96242168
70TSSK60.94906334
71TESK10.93960084
72AURKA0.93680312
73CDK20.92117044
74CAMK1D0.92052075
75ACVR1B0.91775974
76NTRK30.90457036
77PRKCG0.90098672
78CDK60.88551991
79MAP3K100.87436324
80RPS6KB20.86746457
81DYRK1A0.82834627
82PIM10.82513260
83* CDK10.81016568
84VRK10.80598058
85MTOR0.79388725
86FGFR40.79223508
87DDR20.78866126
88MELK0.78538472
89LATS20.76483952
90MAP2K40.75316504
91KSR10.74386214
92NUAK10.73491139
93BMPR1B0.69742451
94PAK30.68121306
95BRSK10.66611104
96SIK20.65905065
97EEF2K0.65763281
98SGK20.64093321
99CDK50.63863127
100CDK180.63486135
101MARK20.62752004
102MET0.62084210
103PLK20.61715658
104CDK150.61437809
105STK110.59403599
106STK390.58892747
107CDK11A0.58886610
108MAP3K90.57874431
109EPHB20.57494098
110ERBB40.56855578
111NME10.56693722
112PRKCZ0.54963680
113PRKD30.54477177
114PRKDC0.51810033
115CDK140.51613174
116CSNK2A10.50901501
117UHMK10.50814690
118CSNK1E0.50658895
119BMX0.50654600
120PDGFRA0.50590213
121MAP3K80.50289075
122PAK20.49555503
123MAPK140.49419489
124PRKAA10.49331951
125CSNK2A20.48404962
126PTK20.48337929
127EIF2AK20.47888432
128WNK40.47813059
129CSNK1D0.47812317
130OXSR10.46872981
131MUSK0.46774107
132AKT10.46118616
133SCYL20.45437698
134GSK3B0.45110075
135PRKCE0.44222392
136CDK30.44205765
137STK160.42852977
138PINK10.42773767
139MAP4K20.41548145
140AKT20.41329930
141CHUK0.39878979
142ERBB20.39281741
143RPS6KA50.38210088
144PRKCI0.34972656
145PAK10.34602019
146CCNB10.34342833
147RPS6KL10.32252588
148RPS6KC10.32252588
149PTK2B0.31520260
150PRPF4B0.30884554
151NEK60.30609139
152RPS6KA60.30444826
153CDK80.30383219
154RPS6KB10.30152274
155STK100.29243370
156FGFR10.29054648
157MAPK10.29033095
158CLK10.28642434
159ALK0.27915317

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.92195653
2Mismatch repair_Homo sapiens_hsa034303.57572945
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33047773
4Fanconi anemia pathway_Homo sapiens_hsa034603.27878791
5Spliceosome_Homo sapiens_hsa030403.24372888
6RNA transport_Homo sapiens_hsa030133.07245326
7Cell cycle_Homo sapiens_hsa041103.04685695
8Homologous recombination_Homo sapiens_hsa034402.95701226
9mRNA surveillance pathway_Homo sapiens_hsa030152.73131148
10Steroid biosynthesis_Homo sapiens_hsa001002.67139333
11Base excision repair_Homo sapiens_hsa034102.58535666
12Nucleotide excision repair_Homo sapiens_hsa034202.55822908
13Basal transcription factors_Homo sapiens_hsa030222.47644060
14One carbon pool by folate_Homo sapiens_hsa006702.44510699
15RNA polymerase_Homo sapiens_hsa030202.41689100
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00988444
17Basal cell carcinoma_Homo sapiens_hsa052171.90398558
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89052930
19p53 signaling pathway_Homo sapiens_hsa041151.85345284
20Non-homologous end-joining_Homo sapiens_hsa034501.81508560
21Pyrimidine metabolism_Homo sapiens_hsa002401.79226178
22RNA degradation_Homo sapiens_hsa030181.75328390
23Systemic lupus erythematosus_Homo sapiens_hsa053221.73763587
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73221180
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71639077
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71356906
27Hedgehog signaling pathway_Homo sapiens_hsa043401.57042156
28Nicotine addiction_Homo sapiens_hsa050331.56899374
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54054212
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49100945
31Hippo signaling pathway_Homo sapiens_hsa043901.44249705
32Proteasome_Homo sapiens_hsa030501.43729216
33Oocyte meiosis_Homo sapiens_hsa041141.39090107
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37878455
35Ribosome_Homo sapiens_hsa030101.32272064
36Propanoate metabolism_Homo sapiens_hsa006401.32201325
37MicroRNAs in cancer_Homo sapiens_hsa052061.28853391
38Notch signaling pathway_Homo sapiens_hsa043301.25643378
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19596499
40TGF-beta signaling pathway_Homo sapiens_hsa043501.18731834
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17972105
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17754438
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17475933
44Butanoate metabolism_Homo sapiens_hsa006501.12809027
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10169200
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10095074
47Purine metabolism_Homo sapiens_hsa002301.07881803
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07274727
49Small cell lung cancer_Homo sapiens_hsa052221.06046796
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05942656
51Biosynthesis of amino acids_Homo sapiens_hsa012301.05064958
52Viral carcinogenesis_Homo sapiens_hsa052031.04093378
53HTLV-I infection_Homo sapiens_hsa051661.03326993
54Protein export_Homo sapiens_hsa030601.00595117
55Herpes simplex infection_Homo sapiens_hsa051680.97774152
56Alcoholism_Homo sapiens_hsa050340.96807411
57Epstein-Barr virus infection_Homo sapiens_hsa051690.96764226
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96449418
59Pyruvate metabolism_Homo sapiens_hsa006200.95740449
60Wnt signaling pathway_Homo sapiens_hsa043100.93577288
61Vitamin B6 metabolism_Homo sapiens_hsa007500.92032691
62Dorso-ventral axis formation_Homo sapiens_hsa043200.89351431
63Fatty acid metabolism_Homo sapiens_hsa012120.88161346
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87987768
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87659236
66Complement and coagulation cascades_Homo sapiens_hsa046100.86043375
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84896672
68Fat digestion and absorption_Homo sapiens_hsa049750.84891110
69Glutamatergic synapse_Homo sapiens_hsa047240.83380047
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.82972008
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.82607946
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82343589
73Adherens junction_Homo sapiens_hsa045200.81309351
74Melanoma_Homo sapiens_hsa052180.78701563
75Prostate cancer_Homo sapiens_hsa052150.77898929
76Cocaine addiction_Homo sapiens_hsa050300.76917609
77Arginine and proline metabolism_Homo sapiens_hsa003300.76107695
78ECM-receptor interaction_Homo sapiens_hsa045120.75350504
79Taste transduction_Homo sapiens_hsa047420.75013303
80Pathways in cancer_Homo sapiens_hsa052000.71174779
81Cardiac muscle contraction_Homo sapiens_hsa042600.70585332
82GABAergic synapse_Homo sapiens_hsa047270.70525140
83Lysine degradation_Homo sapiens_hsa003100.69470381
84Bladder cancer_Homo sapiens_hsa052190.69349187
85Fatty acid degradation_Homo sapiens_hsa000710.68821584
86Retinol metabolism_Homo sapiens_hsa008300.68581058
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66317324
88Dopaminergic synapse_Homo sapiens_hsa047280.65562306
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64061044
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62600511
91Colorectal cancer_Homo sapiens_hsa052100.62463357
92Carbon metabolism_Homo sapiens_hsa012000.61557268
93Arginine biosynthesis_Homo sapiens_hsa002200.61259488
94Bile secretion_Homo sapiens_hsa049760.61078421
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60636241
96Thyroid hormone synthesis_Homo sapiens_hsa049180.60274480
97ABC transporters_Homo sapiens_hsa020100.56892195
98Gap junction_Homo sapiens_hsa045400.56513783
99Dilated cardiomyopathy_Homo sapiens_hsa054140.56353588
100Tight junction_Homo sapiens_hsa045300.54854591
101Fatty acid elongation_Homo sapiens_hsa000620.53304693
102Phototransduction_Homo sapiens_hsa047440.53069918
103Glucagon signaling pathway_Homo sapiens_hsa049220.52905086
104beta-Alanine metabolism_Homo sapiens_hsa004100.52412827
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50206513
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48845943
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48831543
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48713935
109Endometrial cancer_Homo sapiens_hsa052130.47842269
110AMPK signaling pathway_Homo sapiens_hsa041520.47736155
111Insulin secretion_Homo sapiens_hsa049110.47394197
112Proteoglycans in cancer_Homo sapiens_hsa052050.47185943
113Axon guidance_Homo sapiens_hsa043600.46924572
114Long-term depression_Homo sapiens_hsa047300.46372409
115Circadian entrainment_Homo sapiens_hsa047130.45242232
116Histidine metabolism_Homo sapiens_hsa003400.45114881
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45039887
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43182638
119Chronic myeloid leukemia_Homo sapiens_hsa052200.42206074
120Apoptosis_Homo sapiens_hsa042100.41329151
121Selenocompound metabolism_Homo sapiens_hsa004500.39937051
122Arachidonic acid metabolism_Homo sapiens_hsa005900.39334049
123Fatty acid biosynthesis_Homo sapiens_hsa000610.39209627
124Legionellosis_Homo sapiens_hsa051340.38070492
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.38052591
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36805656
127Focal adhesion_Homo sapiens_hsa045100.36588239
128FoxO signaling pathway_Homo sapiens_hsa040680.35972136
129Glutathione metabolism_Homo sapiens_hsa004800.34575834
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.33985225
131Protein digestion and absorption_Homo sapiens_hsa049740.33442785
132Huntingtons disease_Homo sapiens_hsa050160.31713047
133Influenza A_Homo sapiens_hsa051640.31618639
134Hepatitis B_Homo sapiens_hsa051610.31291783
135mTOR signaling pathway_Homo sapiens_hsa041500.31065350
136Melanogenesis_Homo sapiens_hsa049160.30898328
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30708943
138Thyroid cancer_Homo sapiens_hsa052160.30536865
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30419247
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28879437
141Antigen processing and presentation_Homo sapiens_hsa046120.28729566
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26283459
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24428758
144Glioma_Homo sapiens_hsa052140.23095483
145HIF-1 signaling pathway_Homo sapiens_hsa040660.21566229
146Ovarian steroidogenesis_Homo sapiens_hsa049130.21068310
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20253187
148Pancreatic cancer_Homo sapiens_hsa052120.20140915
149Viral myocarditis_Homo sapiens_hsa054160.20127493
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19952079
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19572799
152Mineral absorption_Homo sapiens_hsa049780.18031702
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16894305
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16620835
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15930266
156Olfactory transduction_Homo sapiens_hsa047400.15648843
157Vitamin digestion and absorption_Homo sapiens_hsa049770.14574447
158Amoebiasis_Homo sapiens_hsa051460.12228560
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.12160810

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