NID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by miRNA (GO:0060964)5.20636489
2regulation of gene silencing by RNA (GO:0060966)5.20636489
3regulation of posttranscriptional gene silencing (GO:0060147)5.20636489
4paraxial mesoderm development (GO:0048339)4.93163710
5regulation of cardioblast differentiation (GO:0051890)4.84606861
6endocardial cushion development (GO:0003197)4.74706340
7polarized epithelial cell differentiation (GO:0030859)4.74627966
8establishment of apical/basal cell polarity (GO:0035089)4.63572006
9sequestering of extracellular ligand from receptor (GO:0035581)4.50158429
10atrioventricular valve morphogenesis (GO:0003181)4.45875360
11positive regulation of SMAD protein import into nucleus (GO:0060391)4.39941476
12skin morphogenesis (GO:0043589)4.39069148
13kidney mesenchyme development (GO:0072074)4.38247141
14notochord development (GO:0030903)4.34875309
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.32913043
16regulation of SMAD protein import into nucleus (GO:0060390)4.26843991
17nuclear pore complex assembly (GO:0051292)4.16379840
18nuclear pore organization (GO:0006999)4.13502754
19collagen metabolic process (GO:0032963)3.98543328
20metanephric mesenchyme development (GO:0072075)3.96957432
21establishment of monopolar cell polarity (GO:0061162)3.90211587
22establishment or maintenance of monopolar cell polarity (GO:0061339)3.90211587
23extracellular fibril organization (GO:0043206)3.84416909
24collagen catabolic process (GO:0030574)3.81841249
25cell adhesion mediated by integrin (GO:0033627)3.77904444
26mesenchymal-epithelial cell signaling (GO:0060638)3.72541406
27retina vasculature morphogenesis in camera-type eye (GO:0061299)3.72422075
28multicellular organismal macromolecule metabolic process (GO:0044259)3.69807125
29extracellular matrix assembly (GO:0085029)3.64764668
30pre-miRNA processing (GO:0031054)3.63568081
31hippo signaling (GO:0035329)3.61659842
32* basement membrane organization (GO:0071711)3.54117205
33type B pancreatic cell proliferation (GO:0044342)3.53718341
34atrial septum morphogenesis (GO:0060413)3.52617877
35venous blood vessel morphogenesis (GO:0048845)3.49348656
36multicellular organismal metabolic process (GO:0044236)3.49186201
37multicellular organismal catabolic process (GO:0044243)3.48724468
38pericardium development (GO:0060039)3.46910153
39anterior/posterior axis specification, embryo (GO:0008595)3.46888151
40regulation of hippo signaling (GO:0035330)3.43424464
41extracellular matrix disassembly (GO:0022617)3.41316793
42blood vessel maturation (GO:0001955)3.40509760
43positive regulation of endothelial cell apoptotic process (GO:2000353)3.34945017
44cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34621240
45fibril organization (GO:0097435)3.28488737
46branching involved in salivary gland morphogenesis (GO:0060445)3.19470840
47wound healing, spreading of epidermal cells (GO:0035313)3.18411519
48dermatan sulfate biosynthetic process (GO:0030208)3.18010518
49mesodermal cell differentiation (GO:0048333)3.15803535
50negative regulation of smooth muscle cell migration (GO:0014912)3.15666345
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13357619
52cell migration involved in heart development (GO:0060973)3.11232076
53substrate-dependent cell migration (GO:0006929)3.11188517
54negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.11063238
55cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.08708681
56neuron projection extension involved in neuron projection guidance (GO:1902284)3.07666310
57axon extension involved in axon guidance (GO:0048846)3.07666310
58collagen fibril organization (GO:0030199)3.07370883
59mitotic nuclear envelope disassembly (GO:0007077)3.07025396
60cellular response to vitamin (GO:0071295)3.06482885
61dermatan sulfate metabolic process (GO:0030205)3.06054903
62regulation of translational fidelity (GO:0006450)3.05346905
63epithelial cell-cell adhesion (GO:0090136)3.02423457
64positive regulation of epithelial to mesenchymal transition (GO:0010718)3.02316701
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00808827
66pore complex assembly (GO:0046931)3.00448718
67embryonic foregut morphogenesis (GO:0048617)2.98935475
68heterochromatin organization (GO:0070828)2.98878026
69protein heterotrimerization (GO:0070208)2.98050569
70substrate adhesion-dependent cell spreading (GO:0034446)2.97401027
71* extracellular matrix organization (GO:0030198)2.89988140
72endodermal cell differentiation (GO:0035987)2.89276626
73endothelial cell morphogenesis (GO:0001886)2.88946360
74* extracellular structure organization (GO:0043062)2.88942408
75membrane disassembly (GO:0030397)2.88216297
76nuclear envelope disassembly (GO:0051081)2.88216297
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.87071856
78tooth mineralization (GO:0034505)2.86968294
79positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86958415
80DNA unwinding involved in DNA replication (GO:0006268)2.86620720
81DNA replication-dependent nucleosome assembly (GO:0006335)2.85338904
82DNA replication-dependent nucleosome organization (GO:0034723)2.85338904
83trabecula formation (GO:0060343)2.84101110
84smooth muscle tissue development (GO:0048745)2.83681641
85adherens junction assembly (GO:0034333)2.82969614
86protein localization to kinetochore (GO:0034501)2.82885556
87vascular endothelial growth factor signaling pathway (GO:0038084)2.82851848
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79574911
89peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77668929
90COPI coating of Golgi vesicle (GO:0048205)2.76912082
91Golgi transport vesicle coating (GO:0048200)2.76912082
92negative regulation of chondrocyte differentiation (GO:0032331)2.76349352
93regulation of mitotic spindle organization (GO:0060236)2.76039277
94lymph vessel development (GO:0001945)2.75969416
95outflow tract septum morphogenesis (GO:0003148)2.75389648
96negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.75365993
97craniofacial suture morphogenesis (GO:0097094)2.74529497
98mesenchyme morphogenesis (GO:0072132)2.73031114
99sprouting angiogenesis (GO:0002040)2.71613034
100myofibril assembly (GO:0030239)2.71437941
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.71326741
102cardiac right ventricle morphogenesis (GO:0003215)2.70650148
103heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.69877741
104endocardial cushion morphogenesis (GO:0003203)2.69788366
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69708920
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69707496
107cell migration involved in sprouting angiogenesis (GO:0002042)2.68853074
108chondrocyte development (GO:0002063)2.67533811
109mesenchyme development (GO:0060485)2.67154931
110regulation of axon extension involved in axon guidance (GO:0048841)2.67126181
111artery morphogenesis (GO:0048844)2.66276989
112protein retention in ER lumen (GO:0006621)2.65964262
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.65435100
114negative regulation of heart growth (GO:0061117)2.65435100
115regulation of telomere maintenance via telomerase (GO:0032210)2.65094846
116apoptotic cell clearance (GO:0043277)2.65070731
117regulation of heart morphogenesis (GO:2000826)2.64448752
118vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64367394
119positive regulation of cartilage development (GO:0061036)2.64136770
120gastrulation with mouth forming second (GO:0001702)2.64111462
121regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.63418476
122regulation of spindle organization (GO:0090224)2.62591949
123glomerular basement membrane development (GO:0032836)2.62455742
124protein localization to cell surface (GO:0034394)2.62343297
125extracellular negative regulation of signal transduction (GO:1900116)2.62189132
126extracellular regulation of signal transduction (GO:1900115)2.62189132
127regulation of establishment of planar polarity (GO:0090175)2.61288734
128bone trabecula formation (GO:0060346)2.61009656
129regulation of secondary heart field cardioblast proliferation (GO:0003266)2.60966076
130regulation of cardioblast proliferation (GO:0003264)2.60966076
131negative regulation of cartilage development (GO:0061037)2.60903757
132blood vessel morphogenesis (GO:0048514)2.59708597
133regulation of gene silencing (GO:0060968)2.58923891
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58120876
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57584171
136positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.56487442
137morphogenesis of an epithelial sheet (GO:0002011)2.56399615
138negative regulation of DNA repair (GO:0045738)2.56012768
139chondrocyte proliferation (GO:0035988)2.55157981
140mitotic sister chromatid segregation (GO:0000070)2.53582225
141sister chromatid segregation (GO:0000819)2.53431034
142positive regulation of cardiac muscle cell proliferation (GO:0060045)2.49857123
143ventricular septum development (GO:0003281)2.49151724
144negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.46660051
145cell-substrate junction assembly (GO:0007044)2.46311420
146negative regulation of histone methylation (GO:0031061)2.45096854
147apoptotic process involved in morphogenesis (GO:0060561)2.44511594
148regulation of transforming growth factor beta2 production (GO:0032909)2.41680909
149heart valve morphogenesis (GO:0003179)2.41496611
150somatic hypermutation of immunoglobulin genes (GO:0016446)2.41251660
151somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41251660
152nodal signaling pathway (GO:0038092)2.40272478
153cardiac myofibril assembly (GO:0055003)2.39759784
154regulation of sister chromatid cohesion (GO:0007063)2.39547471
155renal filtration (GO:0097205)2.39329733
156negative regulation of cell fate specification (GO:0009996)2.39252301
157cell-substrate adherens junction assembly (GO:0007045)2.39006580
158focal adhesion assembly (GO:0048041)2.39006580
159embryonic process involved in female pregnancy (GO:0060136)2.38886061
160establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38623546
161DNA duplex unwinding (GO:0032508)2.37997836
162DNA geometric change (GO:0032392)2.37094801
163folic acid-containing compound biosynthetic process (GO:0009396)2.36989332
164lymphangiogenesis (GO:0001946)2.36320721
165glomerular filtration (GO:0003094)2.35604678
166regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.34807112
167regulation of histone H3-K9 methylation (GO:0051570)2.34614794
168embryonic placenta development (GO:0001892)2.34575743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63863046
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.66787925
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.79256697
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.79256697
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.79256697
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.78617488
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.18381996
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.15567627
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.04812323
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.01558848
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.94373991
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.88544676
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78755818
14* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.77835510
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.75108764
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.66497461
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.63681395
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.61002030
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50000893
20* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.46302527
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39423398
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37816834
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36402763
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.35032281
25* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.34006368
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.33946237
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33180055
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27062418
29* CJUN_26792858_Chip-Seq_BT549_Human2.20475146
30TCF3_18692474_ChIP-Seq_MESCs_Mouse2.18508737
31* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.12748714
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.12473958
33* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08931262
34STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03919206
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.00720852
36* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.99320221
37AR_21909140_ChIP-Seq_LNCAP_Human1.98511703
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93259512
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90477927
40ZNF263_19887448_ChIP-Seq_K562_Human1.90043557
41* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86013899
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84850645
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84850645
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83073421
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80474487
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80474487
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78686956
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76406796
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75798436
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75457667
51CLOCK_20551151_ChIP-Seq_293T_Human1.74496800
52TP53_18474530_ChIP-ChIP_U2OS_Human1.74489707
53* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71309258
54* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69860122
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69560868
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.67636496
57* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66412622
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66259384
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66091607
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62031417
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56533636
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56071350
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55855288
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54841655
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54695901
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52506977
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51451953
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.51405392
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50971876
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50896887
71* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50751291
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50465216
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.50100520
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.50100520
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48503115
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.48492605
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47224075
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46777436
79* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46372649
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44407885
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.43788750
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43184511
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42255446
84* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40290135
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39629233
86SA1_22415368_ChIP-Seq_MEFs_Mouse1.38135962
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.35533063
88* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35475136
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35335033
90* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35328972
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34010037
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.33674365
93* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32988371
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.32006543
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.31986901
96* TP53_16413492_ChIP-PET_HCT116_Human1.31677574
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.30303595
98* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29867576
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29349248
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28016412
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27400590
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27133679
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25872077
104* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25510371
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25269917
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24725645
107* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24243783
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24001444
109* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23289614
110* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22907999
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21870507
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.21445647
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21222208
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21140019
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20511420
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20509530
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19627096
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19054994
119* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18795085
120* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18795085
121TP53_23651856_ChIP-Seq_MEFs_Mouse1.17589238
122* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16937195
123* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.16733823
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16585793
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15867185
126BRD4_25478319_ChIP-Seq_HGPS_Human1.15553552
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15136412
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14939157
129* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13955609
130* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13023510
131* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11941648
132NANOG_16153702_ChIP-ChIP_HESCs_Human1.10536862
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10499607
134MYC_22102868_ChIP-Seq_BL_Human1.09754785
135* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08922900
136E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08332196
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08247762
138WT1_19549856_ChIP-ChIP_CCG9911_Human1.07630645
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07471125
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07070367
141ISL1_27105846_Chip-Seq_CPCs_Mouse1.06991314
142XRN2_22483619_ChIP-Seq_HELA_Human1.05673789
143EP300_21415370_ChIP-Seq_HL-1_Mouse1.03206350
144P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02917429
145CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02620765
146ATF3_27146783_Chip-Seq_COLON_Human1.02537623
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02057786
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01330702
149FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01173157
150NANOG_16518401_ChIP-PET_MESCs_Mouse1.01049293
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00792784
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00696121
153UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00679104
154TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99557918
155CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99037540
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98610402
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.97882838
158TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97789682
159ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96646637
160NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95731806
161KDM2B_26808549_Chip-Seq_K562_Human0.94614143
162TP53_22127205_ChIP-Seq_IMR90_Human0.93083089
163AHR_22903824_ChIP-Seq_MCF-7_Human0.91290754
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90774126
165* RING1B_27294783_Chip-Seq_ESCs_Mouse0.90212979
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90077353
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88653744
168* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87892767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.70830664
2MP0008438_abnormal_cutaneous_collagen3.41051070
3MP0003705_abnormal_hypodermis_morpholog3.35178447
4MP0005503_abnormal_tendon_morphology3.05697025
5MP0005623_abnormal_meninges_morphology2.84376301
6MP0005257_abnormal_intraocular_pressure2.83856161
7MP0003941_abnormal_skin_development2.48880174
8MP0003279_aneurysm2.27142886
9MP0010352_gastrointestinal_tract_polyps2.19700637
10MP0003123_paternal_imprinting2.16425641
11MP0010368_abnormal_lymphatic_system2.13885484
12MP0005275_abnormal_skin_tensile2.12576926
13MP0010030_abnormal_orbit_morphology2.10755275
14MP0003567_abnormal_fetal_cardiomyocyte1.94641550
15MP0003566_abnormal_cell_adhesion1.94449618
16MP0004957_abnormal_blastocyst_morpholog1.87186924
17MP0001542_abnormal_bone_strength1.77488893
18MP0003119_abnormal_digestive_system1.77229856
19MP0004197_abnormal_fetal_growth/weight/1.75987604
20MP0002295_abnormal_pulmonary_circulatio1.75287936
21MP0003283_abnormal_digestive_organ1.68492246
22MP0002084_abnormal_developmental_patter1.67172994
23MP0003122_maternal_imprinting1.66774642
24MP0001730_embryonic_growth_arrest1.66114732
25MP0005076_abnormal_cell_differentiation1.65216016
26MP0003385_abnormal_body_wall1.64364211
27MP0004084_abnormal_cardiac_muscle1.61828130
28MP0003121_genomic_imprinting1.61118305
29MP0002086_abnormal_extraembryonic_tissu1.60419426
30MP0000013_abnormal_adipose_tissue1.58134308
31MP0001672_abnormal_embryogenesis/_devel1.55942838
32MP0005380_embryogenesis_phenotype1.55942838
33MP0003984_embryonic_growth_retardation1.55333827
34MP0005508_abnormal_skeleton_morphology1.54577200
35MP0002088_abnormal_embryonic_growth/wei1.54164076
36MP0004133_heterotaxia1.53582463
37MP0000537_abnormal_urethra_morphology1.53541444
38MP0003828_pulmonary_edema1.52593478
39MP0002060_abnormal_skin_morphology1.51893808
40MP0003111_abnormal_nucleus_morphology1.47785295
41MP0002085_abnormal_embryonic_tissue1.46339298
42MP0001299_abnormal_eye_distance/1.44894684
43MP0002108_abnormal_muscle_morphology1.43609789
44MP0001697_abnormal_embryo_size1.42346688
45MP0008057_abnormal_DNA_replication1.41386244
46MP0002282_abnormal_trachea_morphology1.41093964
47MP0009053_abnormal_anal_canal1.37846668
48MP0003077_abnormal_cell_cycle1.36910802
49MP0009250_abnormal_appendicular_skeleto1.36621492
50MP0009384_cardiac_valve_regurgitation1.34613558
51MP0005023_abnormal_wound_healing1.33914350
52MP0002925_abnormal_cardiovascular_devel1.31999589
53MP0003937_abnormal_limbs/digits/tail_de1.30425398
54MP0010094_abnormal_chromosome_stability1.29667589
55MP0000733_abnormal_muscle_development1.29625124
56MP0003942_abnormal_urinary_system1.29228975
57MP0003115_abnormal_respiratory_system1.29030026
58MP0005595_abnormal_vascular_smooth1.28330194
59MP0005367_renal/urinary_system_phenotyp1.28021646
60MP0000516_abnormal_urinary_system1.28021646
61MP0002697_abnormal_eye_size1.26784391
62MP0003935_abnormal_craniofacial_develop1.25704123
63MP0001879_abnormal_lymphatic_vessel1.25279338
64MP0000350_abnormal_cell_proliferation1.24339004
65MP0000428_abnormal_craniofacial_morphol1.21789672
66MP0001915_intracranial_hemorrhage1.21738882
67MP0004145_abnormal_muscle_electrophysio1.20810145
68MP0000767_abnormal_smooth_muscle1.18565996
69MP0001243_abnormal_dermal_layer1.18511603
70MP0001293_anophthalmia1.18236360
71MP0000462_abnormal_digestive_system1.17309111
72MP0006054_spinal_hemorrhage1.16894981
73MP0000751_myopathy1.14242768
74MP0010630_abnormal_cardiac_muscle1.13781574
75MP0003890_abnormal_embryonic-extraembry1.12213617
76MP0004858_abnormal_nervous_system1.12146487
77MP0006138_congestive_heart_failure1.11614846
78MP0000534_abnormal_ureter_morphology1.11602032
79MP0003091_abnormal_cell_migration1.11247945
80MP0004233_abnormal_muscle_weight1.09776265
81MP0000432_abnormal_head_morphology1.09674181
82MP0004134_abnormal_chest_morphology1.08997829
83MP0002127_abnormal_cardiovascular_syste1.08305413
84MP0002932_abnormal_joint_morphology1.06691237
85MP0002111_abnormal_tail_morphology1.06308190
86MP0002249_abnormal_larynx_morphology1.06126274
87MP0003755_abnormal_palate_morphology1.06002507
88MP0004036_abnormal_muscle_relaxation1.05760048
89MP0008007_abnormal_cellular_replicative1.05661211
90MP0002080_prenatal_lethality1.04597496
91MP0000749_muscle_degeneration1.02333242
92MP0000049_abnormal_middle_ear1.02195807
93MP0000750_abnormal_muscle_regeneration1.01847448
94MP0002877_abnormal_melanocyte_morpholog0.99780897
95MP0008932_abnormal_embryonic_tissue0.99054791
96MP0000266_abnormal_heart_morphology0.98797916
97MP0003950_abnormal_plasma_membrane0.98675709
98MP0003693_abnormal_embryo_hatching0.97660436
99MP0001614_abnormal_blood_vessel0.97121260
100MP0002896_abnormal_bone_mineralization0.96841795
101MP0000163_abnormal_cartilage_morphology0.96682398
102MP0005171_absent_coat_pigmentation0.95910897
103MP0009780_abnormal_chondrocyte_physiolo0.94641293
104MP0004087_abnormal_muscle_fiber0.94419172
105MP0005390_skeleton_phenotype0.94397397
106MP0001958_emphysema0.94147094
107MP0000759_abnormal_skeletal_muscle0.91414021
108MP0002269_muscular_atrophy0.90862252
109MP0002128_abnormal_blood_circulation0.90027250
110MP0001849_ear_inflammation0.88203276
111MP0005330_cardiomyopathy0.88137424
112MP0000003_abnormal_adipose_tissue0.87641629
113MP0004510_myositis0.86719862
114MP0002116_abnormal_craniofacial_bone0.86576591
115MP0008775_abnormal_heart_ventricle0.85948975
116MP0000762_abnormal_tongue_morphology0.85867890
117MP0002109_abnormal_limb_morphology0.85843000
118MP0001286_abnormal_eye_development0.85504824
119MP0002653_abnormal_ependyma_morphology0.85299835
120MP0005197_abnormal_uvea_morphology0.84090858
121MP0005620_abnormal_muscle_contractility0.83666370
122MP0002115_abnormal_skeleton_extremities0.83556672
123MP0002133_abnormal_respiratory_system0.77564424
124MP0005388_respiratory_system_phenotype0.77564424
125MP0001348_abnormal_lacrimal_gland0.77008599
126MP0005369_muscle_phenotype0.75102249
127MP0001175_abnormal_lung_morphology0.74941022
128MP0002254_reproductive_system_inflammat0.73606388
129MP0003300_gastrointestinal_ulcer0.72844380
130MP0002113_abnormal_skeleton_development0.72227515
131MP0002233_abnormal_nose_morphology0.70136318
132MP0002933_joint_inflammation0.68237326
133MP0010386_abnormal_urinary_bladder0.68120533
134MP0005164_abnormal_response_to0.65340415
135MP0002114_abnormal_axial_skeleton0.65114228
136MP0002972_abnormal_cardiac_muscle0.64127077
137MP0005165_increased_susceptibility_to0.62826593
138MP0001661_extended_life_span0.62564697

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.48509026
2Vascular tortuosity (HP:0004948)4.66796661
3Follicular hyperkeratosis (HP:0007502)4.37082482
4Arterial tortuosity (HP:0005116)4.27283463
5Fragile skin (HP:0001030)3.63683883
6Cerebral aneurysm (HP:0004944)3.62986827
7Ankle contracture (HP:0006466)3.41413897
8Slender build (HP:0001533)3.37179448
9Peritonitis (HP:0002586)3.35879309
10Premature rupture of membranes (HP:0001788)3.31211902
11Hypoplastic ischia (HP:0003175)3.29165200
12Spondylolisthesis (HP:0003302)3.23256514
13Wrist flexion contracture (HP:0001239)3.21307431
14Shallow orbits (HP:0000586)3.14280203
15Increased variability in muscle fiber diameter (HP:0003557)3.07254064
16Hip contracture (HP:0003273)3.02700793
17Metaphyseal cupping (HP:0003021)2.95705440
18Abnormality of the ischium (HP:0003174)2.91034942
19Mildly elevated creatine phosphokinase (HP:0008180)2.88872953
20Skull defect (HP:0001362)2.87119288
21Vertebral clefting (HP:0008428)2.86489852
22Joint laxity (HP:0001388)2.86164843
23Abnormal vertebral ossification (HP:0100569)2.85061254
24Bowel diverticulosis (HP:0005222)2.84209047
25Wide anterior fontanel (HP:0000260)2.82925636
26Biconcave vertebral bodies (HP:0004586)2.77247590
27Hyperextensible skin (HP:0000974)2.73158534
28Epiphyseal dysplasia (HP:0002656)2.64781612
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.64737369
30Cervical subluxation (HP:0003308)2.64157751
31Vertebral compression fractures (HP:0002953)2.60226409
32Abnormality of skeletal muscle fiber size (HP:0012084)2.57343938
33Ependymoma (HP:0002888)2.53842463
34Neoplasm of the oral cavity (HP:0100649)2.52073772
35Vitreoretinal degeneration (HP:0000655)2.52055868
36Abnormal delivery (HP:0001787)2.51745999
37Spinal rigidity (HP:0003306)2.49841834
38Limited hip movement (HP:0008800)2.49485156
39Elbow flexion contracture (HP:0002987)2.47052255
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44806978
41Short 4th metacarpal (HP:0010044)2.44806978
42Aortic regurgitation (HP:0001659)2.43930939
43Mitral regurgitation (HP:0001653)2.41681005
44Round ear (HP:0100830)2.39787446
45Hypoventilation (HP:0002791)2.37587967
46Coxa vara (HP:0002812)2.35848024
47Coronal craniosynostosis (HP:0004440)2.35028234
48Ulnar bowing (HP:0003031)2.34347013
49Neonatal short-limb short stature (HP:0008921)2.33387378
50Genu recurvatum (HP:0002816)2.33151530
51Increased connective tissue (HP:0009025)2.31289288
52Disproportionate tall stature (HP:0001519)2.31192626
53Overgrowth (HP:0001548)2.30536424
54Ectopia lentis (HP:0001083)2.29662234
55High pitched voice (HP:0001620)2.28489055
56Deviation of the thumb (HP:0009603)2.27948725
57Flat acetabular roof (HP:0003180)2.24569635
58Selective tooth agenesis (HP:0001592)2.23821774
59Short humerus (HP:0005792)2.21455740
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.20632870
61Osteolytic defects of the hand bones (HP:0009699)2.20632870
62Cupped ribs (HP:0000887)2.18561954
63Missing ribs (HP:0000921)2.16858812
64Blue sclerae (HP:0000592)2.15766450
65Broad metatarsal (HP:0001783)2.12575402
66Aplasia/hypoplasia of the humerus (HP:0006507)2.11835956
67Broad thumb (HP:0011304)2.11306272
68Irregular epiphyses (HP:0010582)2.11171144
69Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10650752
70Vertebral hypoplasia (HP:0008417)2.10650752
71Camptodactyly of toe (HP:0001836)2.09342053
72Abnormality of the acetabulum (HP:0003170)2.08706158
73Aortic dissection (HP:0002647)2.08637484
74Mild short stature (HP:0003502)2.06986509
75Breech presentation (HP:0001623)2.06306429
76Nonimmune hydrops fetalis (HP:0001790)2.06284730
77Inguinal hernia (HP:0000023)2.06075997
78Radial bowing (HP:0002986)2.05587440
79Aplasia of the musculature (HP:0100854)2.04866581
80Broad long bones (HP:0005622)2.04769641
81Abnormality of the astrocytes (HP:0100707)2.04328469
82Astrocytoma (HP:0009592)2.04328469
83Mitral valve prolapse (HP:0001634)2.04070326
84Wormian bones (HP:0002645)2.02521079
85Trismus (HP:0000211)2.01905190
86Partial duplication of the phalanx of hand (HP:0009999)2.01586513
87Hypoplasia of the iris (HP:0007676)2.00992032
88Broad phalanx (HP:0006009)2.00677550
89Partial duplication of thumb phalanx (HP:0009944)1.99524772
90Muscle fiber splitting (HP:0003555)1.99032638
91Proximal placement of thumb (HP:0009623)1.98406290
92Aortic valve stenosis (HP:0001650)1.98241962
93Short 1st metacarpal (HP:0010034)1.97959200
94Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97959200
95Bladder diverticulum (HP:0000015)1.97324475
96Abnormality of the pubic bones (HP:0003172)1.96697651
97Infantile muscular hypotonia (HP:0008947)1.96269367
98Broad ribs (HP:0000885)1.94581507
99Aortic aneurysm (HP:0004942)1.94542606
100Broad phalanges of the hand (HP:0009768)1.94395489
101Sprengel anomaly (HP:0000912)1.93286049
102Broad palm (HP:0001169)1.92729191
103Aneurysm (HP:0002617)1.92527783
104Protruding ear (HP:0000411)1.92395328
105Platyspondyly (HP:0000926)1.91110046
106Thoracolumbar scoliosis (HP:0002944)1.90762836
107Mitral stenosis (HP:0001718)1.89237678
108Atrophic scars (HP:0001075)1.89102506
109Colon cancer (HP:0003003)1.89063172
110Pulmonary artery stenosis (HP:0004415)1.88463600
111Soft skin (HP:0000977)1.87911413
112Abnormality of dentin (HP:0010299)1.87631546
113Premature skin wrinkling (HP:0100678)1.87147513
114Osteoarthritis (HP:0002758)1.86511225
115Abnormality of the 4th metacarpal (HP:0010012)1.85485991
116Broad finger (HP:0001500)1.84968554
117Long toe (HP:0010511)1.84562949
118Rib fusion (HP:0000902)1.83135057
119Deviation of the hallux (HP:0010051)1.81821869
120Type 1 muscle fiber predominance (HP:0003803)1.81592644
121Thin ribs (HP:0000883)1.80557416
122Generalized amyotrophy (HP:0003700)1.80139609
123Patent foramen ovale (HP:0001655)1.79436863
124Abnormality of the 1st metacarpal (HP:0010009)1.78265127
125Absent frontal sinuses (HP:0002688)1.78037301
126Joint stiffness (HP:0001387)1.77997567
127Fused cervical vertebrae (HP:0002949)1.77880634
128Morphological abnormality of the middle ear (HP:0008609)1.77551771
129Lymphangioma (HP:0100764)1.77470714
130Short phalanx of the thumb (HP:0009660)1.77430572
131Syringomyelia (HP:0003396)1.77329200
132Spinal cord lesions (HP:0100561)1.77329200
133Medulloblastoma (HP:0002885)1.77302833
134Right ventricular cardiomyopathy (HP:0011663)1.76920610
135Arachnodactyly (HP:0001166)1.76486933
136Hallux valgus (HP:0001822)1.75668308
137Abnormality of femoral epiphyses (HP:0006499)1.74320492
138Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74320492
139Renal duplication (HP:0000075)1.73954034
140Mesomelia (HP:0003027)1.73278798
141Venous insufficiency (HP:0005293)1.73235896
142Hepatoblastoma (HP:0002884)1.72761197
143Short nail (HP:0001799)1.72445387
144Limb-girdle muscle weakness (HP:0003325)1.72151169
145Venous abnormality (HP:0002624)1.72073239
146Shawl scrotum (HP:0000049)1.71828718
147Long eyelashes (HP:0000527)1.71165718
148Deformed tarsal bones (HP:0008119)1.71063450
149Natal tooth (HP:0000695)1.70550887
150Joint contractures involving the joints of the feet (HP:0100492)1.68904082
151Flexion contracture of toe (HP:0005830)1.68904082
152Striae distensae (HP:0001065)1.68679175
153Abnormality of the calcaneus (HP:0008364)1.64410257
154Femoral bowing (HP:0002980)1.63957850
155Abnormality of the proximal phalanges of the hand (HP:0009834)1.63755389
156Abnormality of skull ossification (HP:0002703)1.63747622
157Tracheal stenosis (HP:0002777)1.63414169
158Dilatation of the ascending aorta (HP:0005111)1.63178951
159Adactyly (HP:0009776)1.63117509
160Cardiovascular calcification (HP:0011915)1.62992593
161Calcaneovalgus deformity (HP:0001848)1.62917130
162Preaxial foot polydactyly (HP:0001841)1.61783521
163Limited elbow extension (HP:0001377)1.60929538
164Knee flexion contracture (HP:0006380)1.60660391
165Relative macrocephaly (HP:0004482)1.60097580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.76188640
2CDK124.16930231
3DDR23.06436951
4SCYL22.72854149
5TIE12.72393084
6LATS12.72374201
7EPHA22.42171523
8KDR2.33003771
9NTRK12.22958599
10PKN22.22945796
11NEK92.19880775
12LATS22.18854152
13PDGFRA2.06646909
14STK38L1.96185897
15CDC71.95628541
16NEK21.83335801
17TGFBR11.80636938
18PIK3CG1.78279487
19RIPK11.74807515
20TTN1.71322153
21WEE11.70663284
22TTK1.64332154
23STK381.63254174
24PAK41.62989521
25NEK11.60965019
26MAP3K101.59129210
27RPS6KB21.57619396
28ICK1.55712416
29CDK71.50466612
30EPHB21.48632642
31MET1.46453739
32MTOR1.44895638
33STK31.43037738
34BRD41.42402521
35TRIB31.40794209
36ERN11.35334685
37CDK41.34625557
38PRKD21.33135782
39AKT31.29631470
40PAK21.24327356
41TRPM71.19280025
42GRK71.17995228
43EEF2K1.16680366
44PLK41.14609321
45BUB11.13186967
46PLK11.11868487
47OBSCN1.10490785
48FGFR11.10311053
49ZAK1.09515083
50TGFBR21.07118326
51CDK61.04854633
52STK101.03151016
53PTK21.02995595
54TYRO31.01606028
55MOS1.01404924
56FLT30.99819752
57DMPK0.97844194
58ADRBK10.96537140
59BMX0.95955675
60FER0.94253397
61MAPK70.92344031
62PTK60.92148478
63MAP3K80.91977482
64ROCK20.89567422
65MAP3K30.89197900
66PLK30.89128966
67SIK10.88808340
68RPS6KA20.88589807
69CHEK10.88494379
70CHEK20.86356657
71TSSK60.82920394
72ATR0.82124862
73ERBB40.81569556
74AURKB0.81376155
75KIT0.81187083
76PASK0.79790615
77CAMK1D0.77478955
78BCR0.76420375
79CDK80.75797656
80PRKD30.73863246
81DAPK30.72604610
82MAP3K60.72135293
83MAP3K70.71653405
84STK240.71230231
85ATM0.70752625
86ABL20.68709261
87LMTK20.67173747
88BRSK20.66687988
89PRKG20.65122146
90LRRK20.64702051
91ALK0.64182805
92CDK20.63442112
93CAMK1G0.62786035
94MKNK10.62207203
95ACVR1B0.61637294
96PTK2B0.61543713
97GRK50.60531014
98PDGFRB0.57851466
99RET0.56728184
100PRKD10.54535780
101PDK20.54114183
102AKT20.53688253
103MELK0.53626577
104EPHB10.53497365
105STK40.53317041
106CLK10.52864578
107FGFR40.51173993
108ROCK10.50994824
109MKNK20.48480627
110ILK0.48255824
111TESK10.47454467
112MAPK10.47047373
113PAK10.46585406
114MAP2K30.45304377
115CDC42BPA0.45263318
116WNK10.44868752
117AURKA0.44824822
118PIM10.44816258
119GSK3A0.44665302
120MAP2K10.44443277
121CDK10.43059609
122PNCK0.43030778
123PAK60.42502947
124LIMK10.42198323
125CSNK1D0.41716403
126RPS6KA40.41695119
127MAPKAPK30.41351779
128CDK90.39873672
129DYRK1B0.38971812
130PAK30.38900578
131INSR0.38148966
132AKT10.37549679
133CSNK1E0.37091611
134PLK20.36583836
135PIK3CA0.36002890
136RPS6KC10.34501395
137RPS6KL10.34501395
138JAK10.33064719
139MAPK40.32590408
140PIM20.32419024
141MARK20.31337153
142SRC0.30392479
143SMG10.30082694
144PRKCE0.28290180
145FGFR20.25260238
146KSR20.22458712
147CAMK2G0.22342774

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.84263191
2Adherens junction_Homo sapiens_hsa045202.52387963
3Mismatch repair_Homo sapiens_hsa034302.47478866
4Focal adhesion_Homo sapiens_hsa045102.39678231
5Hippo signaling pathway_Homo sapiens_hsa043902.38576680
6Small cell lung cancer_Homo sapiens_hsa052222.36386038
7RNA transport_Homo sapiens_hsa030132.35776770
8Basal cell carcinoma_Homo sapiens_hsa052172.31801677
9DNA replication_Homo sapiens_hsa030302.27683902
10Cell cycle_Homo sapiens_hsa041102.24145530
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13942601
12One carbon pool by folate_Homo sapiens_hsa006702.02899015
13TGF-beta signaling pathway_Homo sapiens_hsa043502.01471466
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.93920269
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88736783
16Protein digestion and absorption_Homo sapiens_hsa049741.83220253
17Hedgehog signaling pathway_Homo sapiens_hsa043401.80392114
18Proteoglycans in cancer_Homo sapiens_hsa052051.77947071
19MicroRNAs in cancer_Homo sapiens_hsa052061.77795800
20Spliceosome_Homo sapiens_hsa030401.77241059
21Tight junction_Homo sapiens_hsa045301.75578287
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72985015
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.71835221
24Amoebiasis_Homo sapiens_hsa051461.67477473
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60906855
26p53 signaling pathway_Homo sapiens_hsa041151.56372519
27mRNA surveillance pathway_Homo sapiens_hsa030151.53953689
28Dilated cardiomyopathy_Homo sapiens_hsa054141.47970145
29Base excision repair_Homo sapiens_hsa034101.46139483
30Nucleotide excision repair_Homo sapiens_hsa034201.45981975
31Notch signaling pathway_Homo sapiens_hsa043301.43853152
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.42801795
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41708831
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38676522
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33320472
36Pathways in cancer_Homo sapiens_hsa052001.31035265
37Bladder cancer_Homo sapiens_hsa052191.26386418
38Lysine degradation_Homo sapiens_hsa003101.24402197
39Viral myocarditis_Homo sapiens_hsa054161.22867488
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20664974
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.18188455
42Gap junction_Homo sapiens_hsa045401.17270814
43Malaria_Homo sapiens_hsa051441.17086774
44Wnt signaling pathway_Homo sapiens_hsa043101.15752312
45Prion diseases_Homo sapiens_hsa050201.09760417
46HTLV-I infection_Homo sapiens_hsa051661.09468567
47mTOR signaling pathway_Homo sapiens_hsa041501.08446339
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.08033657
49Fanconi anemia pathway_Homo sapiens_hsa034601.07058802
50Homologous recombination_Homo sapiens_hsa034401.06782256
51Thyroid cancer_Homo sapiens_hsa052161.06229190
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02509568
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.01586747
54Colorectal cancer_Homo sapiens_hsa052101.00738782
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.99629261
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97846972
57Viral carcinogenesis_Homo sapiens_hsa052030.96965651
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96104439
59RNA degradation_Homo sapiens_hsa030180.95924569
60Oocyte meiosis_Homo sapiens_hsa041140.93828428
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93541745
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93538126
63HIF-1 signaling pathway_Homo sapiens_hsa040660.93111156
64Prostate cancer_Homo sapiens_hsa052150.90288335
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88138847
66Melanoma_Homo sapiens_hsa052180.87181367
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85804426
68Biosynthesis of amino acids_Homo sapiens_hsa012300.85427669
69Rap1 signaling pathway_Homo sapiens_hsa040150.82886984
70Chronic myeloid leukemia_Homo sapiens_hsa052200.80223346
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79199908
72Other glycan degradation_Homo sapiens_hsa005110.78596241
73Non-homologous end-joining_Homo sapiens_hsa034500.78252608
74Toxoplasmosis_Homo sapiens_hsa051450.76487191
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75007326
76N-Glycan biosynthesis_Homo sapiens_hsa005100.74787097
77Complement and coagulation cascades_Homo sapiens_hsa046100.73782104
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71920460
79Thyroid hormone synthesis_Homo sapiens_hsa049180.71705824
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70935803
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70618807
82Sulfur metabolism_Homo sapiens_hsa009200.68794033
83Melanogenesis_Homo sapiens_hsa049160.67341357
84Basal transcription factors_Homo sapiens_hsa030220.67048079
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67012209
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66443188
87Endometrial cancer_Homo sapiens_hsa052130.66135290
88Endocytosis_Homo sapiens_hsa041440.63848131
89Ras signaling pathway_Homo sapiens_hsa040140.63380397
90Renal cell carcinoma_Homo sapiens_hsa052110.61770455
91Choline metabolism in cancer_Homo sapiens_hsa052310.61233225
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60207146
93Axon guidance_Homo sapiens_hsa043600.59849444
94AMPK signaling pathway_Homo sapiens_hsa041520.59779302
95Galactose metabolism_Homo sapiens_hsa000520.59245553
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.58559345
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58547308
98Selenocompound metabolism_Homo sapiens_hsa004500.57123516
99Ribosome_Homo sapiens_hsa030100.56200884
100RNA polymerase_Homo sapiens_hsa030200.54730853
101Shigellosis_Homo sapiens_hsa051310.52647196
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52143860
103Renin secretion_Homo sapiens_hsa049240.51915633
104MAPK signaling pathway_Homo sapiens_hsa040100.51823404
105Vibrio cholerae infection_Homo sapiens_hsa051100.51196562
106Systemic lupus erythematosus_Homo sapiens_hsa053220.50524598
107Dorso-ventral axis formation_Homo sapiens_hsa043200.50345608
108cAMP signaling pathway_Homo sapiens_hsa040240.50004842
109Calcium signaling pathway_Homo sapiens_hsa040200.49637804
110Insulin resistance_Homo sapiens_hsa049310.48637785
111Renin-angiotensin system_Homo sapiens_hsa046140.48505239
112GnRH signaling pathway_Homo sapiens_hsa049120.48057361
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47569497
114Cocaine addiction_Homo sapiens_hsa050300.46081277
115Carbon metabolism_Homo sapiens_hsa012000.45598342
116Oxytocin signaling pathway_Homo sapiens_hsa049210.45356273
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45226653
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43790842
119Epstein-Barr virus infection_Homo sapiens_hsa051690.43121130
120FoxO signaling pathway_Homo sapiens_hsa040680.42828981
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42246818
122Glucagon signaling pathway_Homo sapiens_hsa049220.41996183
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40669371
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39030701
125Pancreatic cancer_Homo sapiens_hsa052120.37924981
126Platelet activation_Homo sapiens_hsa046110.37704265
127Glioma_Homo sapiens_hsa052140.37618410
128Nitrogen metabolism_Homo sapiens_hsa009100.37310965
129Hepatitis B_Homo sapiens_hsa051610.36190695
130TNF signaling pathway_Homo sapiens_hsa046680.35744304
131Estrogen signaling pathway_Homo sapiens_hsa049150.35728915
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35061046
133Insulin signaling pathway_Homo sapiens_hsa049100.35026879
134VEGF signaling pathway_Homo sapiens_hsa043700.35025310
135Lysosome_Homo sapiens_hsa041420.34109431
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33888664
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.33244771
138ErbB signaling pathway_Homo sapiens_hsa040120.32714842

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