NHLRC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing NCL-1, HT2A and Lin-41 (NHL) family repeats. Mammalian NHL-repeat containing proteins may be involved in a variety of enzymatic processes, including protein modification through ubiquitination. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26338719
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26338719
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.26338719
4modulation by symbiont of host immune response (GO:0052553)5.26338719
5positive regulation by symbiont of host defense response (GO:0052509)5.26338719
6modulation by symbiont of host defense response (GO:0052031)5.26338719
7regulation of interferon-beta biosynthetic process (GO:0045357)4.78203479
8response to pheromone (GO:0019236)4.71698333
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69532339
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26452119
11tryptophan catabolic process (GO:0006569)4.19061017
12indole-containing compound catabolic process (GO:0042436)4.19061017
13indolalkylamine catabolic process (GO:0046218)4.19061017
14tryptophan metabolic process (GO:0006568)4.06944356
15macrophage activation involved in immune response (GO:0002281)3.93403545
16positive regulation of interferon-alpha production (GO:0032727)3.77727439
17indolalkylamine metabolic process (GO:0006586)3.63732376
18regulation of germinal center formation (GO:0002634)3.58039197
19regulation of interferon-alpha production (GO:0032647)3.55469921
20neutrophil activation involved in immune response (GO:0002283)3.55328221
21water-soluble vitamin biosynthetic process (GO:0042364)3.55229284
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.49994828
23neural tube formation (GO:0001841)3.49543562
24intraciliary transport (GO:0042073)3.44238221
25detection of molecule of bacterial origin (GO:0032490)3.42311024
26regulation of cholesterol storage (GO:0010885)3.41846773
27response to host immune response (GO:0052572)3.39473641
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39473641
29low-density lipoprotein particle clearance (GO:0034383)3.38854282
30positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.27636720
31positive regulation of gamma-delta T cell activation (GO:0046645)3.26944429
32cell wall macromolecule metabolic process (GO:0044036)3.26819442
33regulation of hypersensitivity (GO:0002883)3.25612988
34apoptotic cell clearance (GO:0043277)3.22628374
35kynurenine metabolic process (GO:0070189)3.21598747
36response to host (GO:0075136)3.21494892
37response to host defenses (GO:0052200)3.21494892
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21494892
39positive regulation of mast cell degranulation (GO:0043306)3.17740517
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.17740517
41prostate gland growth (GO:0060736)3.13135725
42microglial cell activation (GO:0001774)3.09084343
43preassembly of GPI anchor in ER membrane (GO:0016254)3.07874416
44regulation of non-canonical Wnt signaling pathway (GO:2000050)3.07619335
45GPI anchor metabolic process (GO:0006505)3.05212284
46regulation of B cell receptor signaling pathway (GO:0050855)3.05043501
47phospholipid homeostasis (GO:0055091)3.04048131
48mitochondrial DNA replication (GO:0006264)3.03359382
49protein carboxylation (GO:0018214)3.00764989
50peptidyl-glutamic acid carboxylation (GO:0017187)3.00764989
51positive regulation of mast cell activation (GO:0033005)2.98200867
52I-kappaB phosphorylation (GO:0007252)2.97949145
53macrophage activation (GO:0042116)2.97089970
54cell wall macromolecule catabolic process (GO:0016998)2.95418815
55lipoprotein transport (GO:0042953)2.88023044
56regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.86766495
57positive regulation of antigen processing and presentation (GO:0002579)2.86662809
58adenosine metabolic process (GO:0046085)2.86598654
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86472098
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86472098
61regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.85966458
62plasma lipoprotein particle clearance (GO:0034381)2.85781852
63positive regulation of cellular amide metabolic process (GO:0034250)2.85224875
64cell adhesion mediated by integrin (GO:0033627)2.83645517
65limb bud formation (GO:0060174)2.80185784
66aggressive behavior (GO:0002118)2.80042998
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78430958
68negative regulation of lipid storage (GO:0010888)2.74054019
69antigen processing and presentation of endogenous antigen (GO:0019883)2.72076622
70vitamin biosynthetic process (GO:0009110)2.71954640
71piRNA metabolic process (GO:0034587)2.71232207
72positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.70823462
73pinocytosis (GO:0006907)2.70439220
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70117684
75production of molecular mediator involved in inflammatory response (GO:0002532)2.69639109
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.69331766
77hyaluronan catabolic process (GO:0030214)2.68051478
78behavioral response to nicotine (GO:0035095)2.67797888
79cellular response to ethanol (GO:0071361)2.67038960
80positive regulation of p38MAPK cascade (GO:1900745)2.65808307
81GPI anchor biosynthetic process (GO:0006506)2.64777989
82mannose metabolic process (GO:0006013)2.63258051
83phospholipid efflux (GO:0033700)2.61178793
84epithelial cilium movement (GO:0003351)2.60311992
85positive regulation of interferon-beta production (GO:0032728)2.60210021
86L-ascorbic acid metabolic process (GO:0019852)2.59478047
87protein localization to cilium (GO:0061512)2.59200383
88negative regulation of granulocyte differentiation (GO:0030853)2.59038706
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58543351
90L-alpha-amino acid transmembrane transport (GO:1902475)2.58235465
91detection of external biotic stimulus (GO:0098581)2.57544741
92benzene-containing compound metabolic process (GO:0042537)2.56510899
93transepithelial transport (GO:0070633)2.55822226
94neutrophil activation (GO:0042119)2.54853342
95synapsis (GO:0007129)2.53940433
96regulation of meiosis I (GO:0060631)2.53578381
97negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53457627
98alpha-linolenic acid metabolic process (GO:0036109)2.53425544
99photoreceptor cell maintenance (GO:0045494)2.53276147
100myeloid cell activation involved in immune response (GO:0002275)2.53210352
101cell differentiation involved in metanephros development (GO:0072202)2.53141900
102immunoglobulin mediated immune response (GO:0016064)2.52985100
103respiratory burst (GO:0045730)2.52402688
104granulocyte activation (GO:0036230)2.52166474
105response to peptidoglycan (GO:0032494)2.51832912
106centriole replication (GO:0007099)2.51349316
107protein-lipid complex assembly (GO:0065005)2.49550718
108positive regulation of histone H3-K4 methylation (GO:0051571)2.49079719
109detection of biotic stimulus (GO:0009595)2.48609681
110valine metabolic process (GO:0006573)2.48359520
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47663001
112response to muramyl dipeptide (GO:0032495)2.47301549
113cilium organization (GO:0044782)2.47080826
114kidney morphogenesis (GO:0060993)2.47044601
115L-fucose catabolic process (GO:0042355)2.46922024
116fucose catabolic process (GO:0019317)2.46922024
117L-fucose metabolic process (GO:0042354)2.46922024
118aromatic amino acid family catabolic process (GO:0009074)2.46726406
119platelet dense granule organization (GO:0060155)2.46252305
120plasma lipoprotein particle assembly (GO:0034377)2.46005425
121nonmotile primary cilium assembly (GO:0035058)2.45784128
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44862161
123positive regulation of blood coagulation (GO:0030194)2.44708484
124positive regulation of hemostasis (GO:1900048)2.44708484
125complement activation, alternative pathway (GO:0006957)2.44607341
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.44583631
127lipoprotein metabolic process (GO:0042157)2.44084426
128regulation of antigen processing and presentation (GO:0002577)2.43416780
129fat-soluble vitamin biosynthetic process (GO:0042362)2.42913941
130regulation of cilium movement (GO:0003352)2.42602273
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.42487420
132cilium or flagellum-dependent cell motility (GO:0001539)2.41171214
133regulation of mononuclear cell migration (GO:0071675)2.41038306
134indole-containing compound metabolic process (GO:0042430)2.40791144
135cilium assembly (GO:0042384)2.40433149
136regulation of integrin activation (GO:0033623)2.40122231
137amine catabolic process (GO:0009310)2.40022326
138cellular biogenic amine catabolic process (GO:0042402)2.40022326
139low-density lipoprotein particle remodeling (GO:0034374)2.39368658
140positive regulation of prostaglandin secretion (GO:0032308)2.38206669
141positive regulation of chemokine secretion (GO:0090197)2.38125331
142basic amino acid transport (GO:0015802)2.38094892
143urea cycle (GO:0000050)2.37645884
144urea metabolic process (GO:0019627)2.37645884
145regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37472070
146branched-chain amino acid catabolic process (GO:0009083)2.37393326
147positive regulation of coagulation (GO:0050820)2.36846369
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36697455
149regulation of gamma-delta T cell activation (GO:0046643)2.36626070
150pyrimidine-containing compound transmembrane transport (GO:0072531)2.35789477
151somite development (GO:0061053)2.35615430
152ubiquinone biosynthetic process (GO:0006744)2.35596476
153C-terminal protein lipidation (GO:0006501)2.35118663
154negative regulation of mast cell activation (GO:0033004)2.35020937
155S-adenosylmethionine metabolic process (GO:0046500)2.34328296
156positive regulation of phagocytosis (GO:0050766)2.34074889
157axoneme assembly (GO:0035082)2.33450379
158cholesterol efflux (GO:0033344)2.33388054
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33387085
160negative regulation of interleukin-1 beta production (GO:0032691)2.32160973
161regulation of inflammatory response to antigenic stimulus (GO:0002861)2.31823244
162positive regulation of B cell differentiation (GO:0045579)2.30080868
163positive regulation of glycolytic process (GO:0045821)2.29801766
164regulation of macrophage derived foam cell differentiation (GO:0010743)2.29188034
165wound healing, spreading of epidermal cells (GO:0035313)2.28400736
166modification by symbiont of host morphology or physiology (GO:0044003)2.27855297
167transcytosis (GO:0045056)2.27112762
168regulation of interleukin-12 biosynthetic process (GO:0045075)2.27068242
169regulation of mast cell activation (GO:0033003)2.26410307
170oligosaccharide catabolic process (GO:0009313)2.26122586
171negative regulation of interleukin-12 production (GO:0032695)2.26106437
172DNA double-strand break processing (GO:0000729)2.25900742
173regulation of interleukin-8 biosynthetic process (GO:0045414)2.24975842
174regulation of gamma-delta T cell differentiation (GO:0045586)2.24639652
175cilium morphogenesis (GO:0060271)2.23087609
176reverse cholesterol transport (GO:0043691)2.23056370
177cytokine secretion (GO:0050663)2.22087839
178regulation of protein activation cascade (GO:2000257)2.22055545
179cilium movement (GO:0003341)2.21898294
180NAD biosynthetic process (GO:0009435)2.21770634
181response to nitrosative stress (GO:0051409)2.21394980
182xenobiotic catabolic process (GO:0042178)2.21277441
183regulation of prostaglandin secretion (GO:0032306)2.20259496
184response to laminar fluid shear stress (GO:0034616)2.20136141
185response to vitamin E (GO:0033197)2.19921920
186seminiferous tubule development (GO:0072520)2.19895672
187regulation of phagocytosis (GO:0050764)2.19195189
188vitamin D metabolic process (GO:0042359)2.18159685
189quinone biosynthetic process (GO:1901663)2.18125389
190regulation of membrane protein ectodomain proteolysis (GO:0051043)2.17901523
191natural killer cell activation involved in immune response (GO:0002323)2.17585271
192keratan sulfate catabolic process (GO:0042340)2.17567486
193aromatic amino acid family metabolic process (GO:0009072)2.17565869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.66264676
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.39502044
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90462497
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.57128350
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42858322
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.27393610
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11150875
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.08479798
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95516714
10IGF1R_20145208_ChIP-Seq_DFB_Human2.93671839
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93418475
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.91508418
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84227417
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82389998
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79533983
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79208894
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.77230661
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.72217383
19ZNF274_21170338_ChIP-Seq_K562_Hela2.66540299
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.52775014
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51141506
22TAF15_26573619_Chip-Seq_HEK293_Human2.50230460
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50140145
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.41949451
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.35367304
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32677114
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31567776
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30980255
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29676126
30GBX2_23144817_ChIP-Seq_PC3_Human2.26029803
31* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18550624
32EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18536372
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18500299
34VDR_22108803_ChIP-Seq_LS180_Human2.18380112
35TP63_17297297_ChIP-ChIP_HaCaT_Human2.10693858
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09956119
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05805845
38FUS_26573619_Chip-Seq_HEK293_Human2.05348454
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01745546
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97229545
41EWS_26573619_Chip-Seq_HEK293_Human1.95798186
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95594417
43ER_23166858_ChIP-Seq_MCF-7_Human1.93142722
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84686935
45P300_19829295_ChIP-Seq_ESCs_Human1.83826921
46GATA1_22025678_ChIP-Seq_K562_Human1.78826274
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77892176
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73203236
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72220956
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71431348
51SCL_19346495_ChIP-Seq_HPC-7_Human1.70924402
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69429686
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67546562
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.65261594
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.59526575
56SPI1_23127762_ChIP-Seq_K562_Human1.58057518
57RUNX_20019798_ChIP-Seq_JUKART_Human1.56947647
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55496710
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55283577
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55100255
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54510649
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54047034
63CLOCK_20551151_ChIP-Seq_293T_Human1.53724589
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53582744
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.52694263
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52263701
67BCAT_22108803_ChIP-Seq_LS180_Human1.51983760
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51839871
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50947590
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.48764425
71PU_27001747_Chip-Seq_BMDM_Mouse1.48606527
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47581574
73CBP_20019798_ChIP-Seq_JUKART_Human1.47581574
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45990632
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44789979
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43858839
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43641315
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41212602
79IRF1_19129219_ChIP-ChIP_H3396_Human1.41055910
80VDR_24787735_ChIP-Seq_THP-1_Human1.40903847
81NANOG_19829295_ChIP-Seq_ESCs_Human1.39782356
82SOX2_19829295_ChIP-Seq_ESCs_Human1.39782356
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.39566748
84MAF_26560356_Chip-Seq_TH1_Human1.39446488
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38540425
86* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38450504
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.37620117
88* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37605463
89SMAD4_21799915_ChIP-Seq_A2780_Human1.37417064
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37188516
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36856803
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36671914
93STAT3_23295773_ChIP-Seq_U87_Human1.35863881
94AR_25329375_ChIP-Seq_VCAP_Human1.35845180
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35469748
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35284779
97* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34716437
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34665479
99VDR_24763502_ChIP-Seq_THP-1_Human1.34423700
100TCF4_23295773_ChIP-Seq_U87_Human1.34301072
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.34290660
102TCF4_22108803_ChIP-Seq_LS180_Human1.33609784
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31776816
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31550708
105TCF7_22412390_ChIP-Seq_EML_Mouse1.31182868
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.30972924
107SPI1_23547873_ChIP-Seq_NB4_Human1.30147440
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30062144
109VDR_21846776_ChIP-Seq_THP-1_Human1.30008206
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29645777
111* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29336219
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28676492
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.27124527
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27103816
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27103816
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26519962
117* MYB_26560356_Chip-Seq_TH2_Human1.26320104
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25601053
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.25249629
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25179264
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24814624
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24330679
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24269675
124CDX2_22108803_ChIP-Seq_LS180_Human1.24261439
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23975916
126* P53_22387025_ChIP-Seq_ESCs_Mouse1.23377624
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23332420
128* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22951987
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22944146
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.21989515
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.21969445
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19044160
133P300_18555785_Chip-Seq_ESCs_Mouse1.18547437
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18157018
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.18061659
136TRIM28_21343339_ChIP-Seq_HEK293_Human1.17802550
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17572991
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.17498418
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17408884
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.17287874
141E2F1_18555785_Chip-Seq_ESCs_Mouse1.16760183
142MYB_26560356_Chip-Seq_TH1_Human1.16751313
143* RUNX2_22187159_ChIP-Seq_PCA_Human1.16393238
144TAL1_26923725_Chip-Seq_HPCs_Mouse1.16218291
145GATA4_25053715_ChIP-Seq_YYC3_Human1.16043708
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15702324
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14668200
148GATA3_26560356_Chip-Seq_TH2_Human1.14563298
149* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14509517
150CMYC_18555785_Chip-Seq_ESCs_Mouse1.14272460
151TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13780944
152FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13523218
153ELK1_19687146_ChIP-ChIP_HELA_Human1.12895206
154NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12804318
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12305801
156SOX2_20726797_ChIP-Seq_SW620_Human1.12058188
157GATA1_19941826_ChIP-Seq_K562_Human1.12002278
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11780194
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11780194
160FOXA2_19822575_ChIP-Seq_HepG2_Human1.11409470
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10343959
162AR_20517297_ChIP-Seq_VCAP_Human1.09983119
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09502493
164SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08643737
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08562729
166CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08432077
167GATA2_19941826_ChIP-Seq_K562_Human1.08253198
168SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07667239
169EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07526581
170TP53_22573176_ChIP-Seq_HFKS_Human1.06810815
171OCT4_18555785_Chip-Seq_ESCs_Mouse1.06453063
172GATA6_25053715_ChIP-Seq_YYC3_Human1.06372198
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06282755
174CDX2_20551321_ChIP-Seq_CACO-2_Human1.06040425
175UTX_26944678_Chip-Seq_JUKART_Human1.05833304
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05681295
177ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05675031
178* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04096017
179KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00046529
180GATA1_19941827_ChIP-Seq_MEL_Mouse0.98868335
181MYC_22102868_ChIP-Seq_BL_Human0.97605590
182GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96507326
183TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96202104
184KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95844828
185SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93800135
186RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93757053
187NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91211643
188NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91211643
189KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89740485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.60378055
2MP0000569_abnormal_digit_pigmentation3.12141300
3MP0005360_urolithiasis2.90101134
4MP0008877_abnormal_DNA_methylation2.80468619
5MP0003787_abnormal_imprinting2.75829853
6MP0009840_abnormal_foam_cell2.74305967
7MP0005646_abnormal_pituitary_gland2.71534202
8MP0001835_abnormal_antigen_presentation2.63239987
9MP0003303_peritoneal_inflammation2.61841925
10MP0002139_abnormal_hepatobiliary_system2.59789035
11MP0003172_abnormal_lysosome_physiology2.58555356
12MP0003191_abnormal_cellular_cholesterol2.58267422
13MP0003436_decreased_susceptibility_to2.55137486
14MP0000372_irregular_coat_pigmentation2.55071906
15MP0006082_CNS_inflammation2.27971772
16MP0004147_increased_porphyrin_level2.27563335
17MP0003705_abnormal_hypodermis_morpholog2.24963215
18MP0002419_abnormal_innate_immunity2.19515817
19MP0003300_gastrointestinal_ulcer2.18930588
20MP0005365_abnormal_bile_salt2.17533726
21MP0005075_abnormal_melanosome_morpholog2.02178743
22MP0005464_abnormal_platelet_physiology2.02085226
23MP0008057_abnormal_DNA_replication2.01048589
24MP0005257_abnormal_intraocular_pressure1.98901375
25MP0003122_maternal_imprinting1.92988507
26MP0005085_abnormal_gallbladder_physiolo1.89970813
27MP0003121_genomic_imprinting1.79026425
28MP0003252_abnormal_bile_duct1.77795336
29MP0004947_skin_inflammation1.75632557
30MP0005025_abnormal_response_to1.74802103
31MP0005000_abnormal_immune_tolerance1.74450146
32MP0001790_abnormal_immune_system1.74260106
33MP0005387_immune_system_phenotype1.74260106
34MP0002452_abnormal_antigen_presenting1.73312900
35MP0001986_abnormal_taste_sensitivity1.70579678
36MP0002909_abnormal_adrenal_gland1.69192688
37MP0010329_abnormal_lipoprotein_level1.66647332
38MP0000685_abnormal_immune_system1.65572495
39MP0003566_abnormal_cell_adhesion1.64679586
40MP0002148_abnormal_hypersensitivity_rea1.60904952
41MP0009785_altered_susceptibility_to1.60794973
42MP0001800_abnormal_humoral_immune1.60744519
43MP0010386_abnormal_urinary_bladder1.60619766
44MP0005083_abnormal_biliary_tract1.59756791
45MP0001533_abnormal_skeleton_physiology1.56401606
46MP0003724_increased_susceptibility_to1.56328863
47MP0006292_abnormal_olfactory_placode1.55443049
48MP0004043_abnormal_pH_regulation1.51901678
49MP0008438_abnormal_cutaneous_collagen1.51658020
50MP0003183_abnormal_peptide_metabolism1.49077768
51MP0002723_abnormal_immune_serum1.49002190
52MP0006054_spinal_hemorrhage1.47977700
53MP0005551_abnormal_eye_electrophysiolog1.44211265
54MP0009697_abnormal_copulation1.42507636
55MP0001984_abnormal_olfaction1.42034854
56MP0002138_abnormal_hepatobiliary_system1.41845304
57MP0001845_abnormal_inflammatory_respons1.40814923
58MP0005671_abnormal_response_to1.39101836
59MP0008875_abnormal_xenobiotic_pharmacok1.38795453
60MP0010234_abnormal_vibrissa_follicle1.38784764
61MP0001819_abnormal_immune_cell1.35594448
62MP0000609_abnormal_liver_physiology1.35371980
63MP0001764_abnormal_homeostasis1.33550719
64MP0002420_abnormal_adaptive_immunity1.32805704
65MP0010155_abnormal_intestine_physiology1.31959419
66MP0009278_abnormal_bone_marrow1.30735633
67MP0005253_abnormal_eye_physiology1.29174180
68MP0005379_endocrine/exocrine_gland_phen1.27933341
69MP0008469_abnormal_protein_level1.27929051
70MP0002638_abnormal_pupillary_reflex1.26417875
71MP0008789_abnormal_olfactory_epithelium1.23146859
72MP0002102_abnormal_ear_morphology1.22384380
73MP0000604_amyloidosis1.20853503
74MP0010352_gastrointestinal_tract_polyps1.20361051
75MP0002998_abnormal_bone_remodeling1.19290843
76MP0005076_abnormal_cell_differentiation1.19174849
77MP0005367_renal/urinary_system_phenotyp1.18973541
78MP0000516_abnormal_urinary_system1.18973541
79MP0002166_altered_tumor_susceptibility1.17798786
80MP0006072_abnormal_retinal_apoptosis1.16162825
81MP0004510_myositis1.15609816
82MP0002254_reproductive_system_inflammat1.15048330
83MP0009764_decreased_sensitivity_to1.14483573
84MP0010307_abnormal_tumor_latency1.13231650
85MP0002405_respiratory_system_inflammati1.12784455
86MP0000858_altered_metastatic_potential1.10706638
87MP0002009_preneoplasia1.10541966
88MP0001666_abnormal_nutrient_absorption1.10463792
89MP0003448_altered_tumor_morphology1.10295182
90MP0001853_heart_inflammation1.10001656
91MP0000383_abnormal_hair_follicle1.08756935
92MP0001958_emphysema1.08332868
93MP0002090_abnormal_vision1.07942798
94MP0002876_abnormal_thyroid_physiology1.06997464
95MP0005167_abnormal_blood-brain_barrier1.06586981
96MP0003453_abnormal_keratinocyte_physiol1.05769262
97MP0000427_abnormal_hair_cycle1.05175648
98MP0004185_abnormal_adipocyte_glucose1.04065573
99MP0005084_abnormal_gallbladder_morpholo1.02423971
100MP0001756_abnormal_urination1.02372186
101MP0005670_abnormal_white_adipose1.01463353
102MP0004130_abnormal_muscle_cell1.00149260
103MP0003091_abnormal_cell_migration0.99838796
104MP0001324_abnormal_eye_pigmentation0.99425504
105MP0005310_abnormal_salivary_gland0.99347114
106MP0005023_abnormal_wound_healing0.99221596
107MP0000631_abnormal_neuroendocrine_gland0.99142126
108MP0000343_altered_response_to0.99028141
109MP0000465_gastrointestinal_hemorrhage0.98580581
110MP0002118_abnormal_lipid_homeostasis0.97783734
111MP0003195_calcinosis0.97024051
112MP0000716_abnormal_immune_system0.96545864
113MP0001873_stomach_inflammation0.95271831
114MP0005174_abnormal_tail_pigmentation0.94546309
115MP0002837_dystrophic_cardiac_calcinosis0.94081205
116MP0009763_increased_sensitivity_to0.93764212
117MP0003690_abnormal_glial_cell0.93717833
118MP0003656_abnormal_erythrocyte_physiolo0.93690671
119MP0000371_diluted_coat_color0.92593251
120MP0009046_muscle_twitch0.89816183
121MP0000767_abnormal_smooth_muscle0.89403113
122MP0004019_abnormal_vitamin_homeostasis0.88821722
123MP0004782_abnormal_surfactant_physiolog0.88678555
124MP0000598_abnormal_liver_morphology0.88319527
125MP0008004_abnormal_stomach_pH0.88178945
126MP0001881_abnormal_mammary_gland0.87666344
127MP0009643_abnormal_urine_homeostasis0.86882596
128MP0003075_altered_response_to0.86804171
129MP0001915_intracranial_hemorrhage0.85809425
130MP0002229_neurodegeneration0.85614497
131MP0005166_decreased_susceptibility_to0.83910425
132MP0002006_tumorigenesis0.83580256
133MP0000689_abnormal_spleen_morphology0.83568594
134MP0010368_abnormal_lymphatic_system0.83170099
135MP0005647_abnormal_sex_gland0.82824764
136MP0002398_abnormal_bone_marrow0.82736461
137MP0004742_abnormal_vestibular_system0.82636820
138MP0005319_abnormal_enzyme/_coenzyme0.82417284
139MP0002136_abnormal_kidney_physiology0.82321356
140MP0000647_abnormal_sebaceous_gland0.82053453
141MP0002095_abnormal_skin_pigmentation0.81412304
142MP0001486_abnormal_startle_reflex0.81394108
143MP0005332_abnormal_amino_acid0.80633595
144MP0005397_hematopoietic_system_phenotyp0.79817510
145MP0001545_abnormal_hematopoietic_system0.79817510
146MP0002933_joint_inflammation0.79442014
147MP0004883_abnormal_blood_vessel0.78985982
148MP0006036_abnormal_mitochondrial_physio0.78920459
149MP0003011_delayed_dark_adaptation0.78834811
150MP0006276_abnormal_autonomic_nervous0.78702066
151MP0003718_maternal_effect0.78337962
152MP0005499_abnormal_olfactory_system0.77924383
153MP0005394_taste/olfaction_phenotype0.77924383
154MP0008872_abnormal_physiological_respon0.77717940
155MP0004142_abnormal_muscle_tone0.76327483
156MP0005389_reproductive_system_phenotype0.75560394

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.63536788
2Increased cerebral lipofuscin (HP:0011813)4.49067662
3Recurrent gram-negative bacterial infections (HP:0005420)4.36529668
4Recurrent abscess formation (HP:0002722)4.17943851
5Eczematoid dermatitis (HP:0000976)4.11112762
6Recurrent bacterial skin infections (HP:0005406)4.06727019
7Vacuolated lymphocytes (HP:0001922)3.94801028
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.94064918
9Myocardial infarction (HP:0001658)3.47286247
10Dysostosis multiplex (HP:0000943)3.45329595
11Abnormality of macrophages (HP:0004311)3.41751991
12Complement deficiency (HP:0004431)3.41469454
13Glomerulonephritis (HP:0000099)3.40917589
14Mucopolysacchariduria (HP:0008155)3.32274301
15Urinary glycosaminoglycan excretion (HP:0003541)3.32274301
16Pancreatic cysts (HP:0001737)3.31904592
17Abnormality of polysaccharide metabolism (HP:0011012)3.27779062
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.27779062
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.27779062
20Autoimmune thrombocytopenia (HP:0001973)3.12210192
21Abnormality of complement system (HP:0005339)3.06033895
22Tetraparesis (HP:0002273)3.04785826
23Abnormality of glycolipid metabolism (HP:0010969)3.04371762
24Abnormality of liposaccharide metabolism (HP:0010968)3.04371762
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.04371762
26Nephronophthisis (HP:0000090)2.97236074
27Abnormality of the prostate (HP:0008775)2.95270232
28Abnormal biliary tract physiology (HP:0012439)2.87592411
29Bile duct proliferation (HP:0001408)2.87592411
30Abnormality of the renal medulla (HP:0100957)2.87502007
31Axonal loss (HP:0003447)2.85019789
32Medial flaring of the eyebrow (HP:0010747)2.84608687
33Abnormality of the renal cortex (HP:0011035)2.84151400
34True hermaphroditism (HP:0010459)2.81250960
35Deep venous thrombosis (HP:0002625)2.81052847
36Periodontitis (HP:0000704)2.79347875
37Pancreatic fibrosis (HP:0100732)2.79214493
38Hematochezia (HP:0002573)2.78000387
39Xanthomatosis (HP:0000991)2.76347028
40Nephritis (HP:0000123)2.75748043
41Tubulointerstitial nephritis (HP:0001970)2.74489106
42Stomach cancer (HP:0012126)2.74262980
43Joint hemorrhage (HP:0005261)2.70823890
44Loss of speech (HP:0002371)2.70394021
45Gingivitis (HP:0000230)2.69594070
46Decreased central vision (HP:0007663)2.66818167
47Abolished electroretinogram (ERG) (HP:0000550)2.65463323
48Congenital hepatic fibrosis (HP:0002612)2.64114944
49Cerebral aneurysm (HP:0004944)2.62627217
50Recurrent skin infections (HP:0001581)2.57994656
51Esophageal varix (HP:0002040)2.57555283
52Disinhibition (HP:0000734)2.56496146
53Molar tooth sign on MRI (HP:0002419)2.54603233
54Abnormality of midbrain morphology (HP:0002418)2.54603233
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54494393
56Renal cortical cysts (HP:0000803)2.53172426
57Hyperventilation (HP:0002883)2.49398099
58Abnormality of macular pigmentation (HP:0008002)2.49328354
59Thyroiditis (HP:0100646)2.48801363
60Abnormality of B cell number (HP:0010975)2.48668543
61Bone pain (HP:0002653)2.45360876
62Thin bony cortex (HP:0002753)2.44226277
63Gingival bleeding (HP:0000225)2.43549356
64Panhypogammaglobulinemia (HP:0003139)2.43511009
65Upper motor neuron abnormality (HP:0002127)2.43066489
66Nephrogenic diabetes insipidus (HP:0009806)2.38008858
67Mediastinal lymphadenopathy (HP:0100721)2.37929296
68Hypothermia (HP:0002045)2.35723851
69Pustule (HP:0200039)2.33536436
70Recurrent fungal infections (HP:0002841)2.32904025
71Osteolytic defects of the hand bones (HP:0009699)2.30210159
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.30210159
73Mutism (HP:0002300)2.27884817
74Tubulointerstitial abnormality (HP:0001969)2.27662513
75Abnormality of the common coagulation pathway (HP:0010990)2.26690489
76Hypercholesterolemia (HP:0003124)2.24711631
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24572769
78Widely spaced teeth (HP:0000687)2.24409440
79Interstitial pulmonary disease (HP:0006530)2.21823358
80Myositis (HP:0100614)2.21728869
81Abnormality of the labia minora (HP:0012880)2.19132212
82Hydroxyprolinuria (HP:0003080)2.19024396
83Abnormality of proline metabolism (HP:0010907)2.19024396
84Pathologic fracture (HP:0002756)2.18581629
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.16796402
86Absent/shortened dynein arms (HP:0200106)2.16796402
87Congenital primary aphakia (HP:0007707)2.16538611
88Elevated erythrocyte sedimentation rate (HP:0003565)2.16401519
89Epidermoid cyst (HP:0200040)2.15568877
90Intrahepatic cholestasis (HP:0001406)2.14613423
91B lymphocytopenia (HP:0010976)2.14355272
92Aortic aneurysm (HP:0004942)2.13159467
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11088745
94Retinal atrophy (HP:0001105)2.08261425
95Gait imbalance (HP:0002141)2.06144445
96Orchitis (HP:0100796)2.05269075
97Menorrhagia (HP:0000132)2.04526530
98Prostate neoplasm (HP:0100787)2.03973848
99Cystic liver disease (HP:0006706)2.02290133
100Hyperlipoproteinemia (HP:0010980)2.01941503
101Recurrent viral infections (HP:0004429)2.01937137
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.99509901
103Urticaria (HP:0001025)1.97636802
104Hypoalphalipoproteinemia (HP:0003233)1.96852480
105Osteomyelitis (HP:0002754)1.96393921
106Arterial thrombosis (HP:0004420)1.96014586
107Peripheral demyelination (HP:0011096)1.95348788
108Attenuation of retinal blood vessels (HP:0007843)1.95226985
109Thoracic kyphosis (HP:0002942)1.94529037
110Methylmalonic acidemia (HP:0002912)1.94465617
111Abnormal rod and cone electroretinograms (HP:0008323)1.94054839
112Abnormal drinking behavior (HP:0030082)1.93951699
113Polydipsia (HP:0001959)1.93951699
114Mitral stenosis (HP:0001718)1.93665833
115Genital tract atresia (HP:0001827)1.93597464
116Obstructive lung disease (HP:0006536)1.93021573
117Chronic obstructive pulmonary disease (HP:0006510)1.93021573
118Volvulus (HP:0002580)1.92944812
119Global brain atrophy (HP:0002283)1.91882835
120Abnormality of the lumbar spine (HP:0100712)1.91653370
121Vaginal atresia (HP:0000148)1.90984246
122Spontaneous hematomas (HP:0007420)1.89988284
123Stomatitis (HP:0010280)1.88950207
124Optic neuritis (HP:0100653)1.88898613
125Retrobulbar optic neuritis (HP:0100654)1.88898613
126Abnormal sex determination (HP:0012244)1.88804994
127Sex reversal (HP:0012245)1.88804994
128Colon cancer (HP:0003003)1.86858014
129Colitis (HP:0002583)1.86438595
130Peritonitis (HP:0002586)1.85494494
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84102391
132Vasculitis (HP:0002633)1.83572865
133Chronic mucocutaneous candidiasis (HP:0002728)1.83064802
134Recurrent cutaneous fungal infections (HP:0011370)1.83064802
135Congenital stationary night blindness (HP:0007642)1.82870510
136Median cleft lip (HP:0000161)1.82631895
137Progressive inability to walk (HP:0002505)1.82587330
138Autoimmune hemolytic anemia (HP:0001890)1.82153465
139Macular degeneration (HP:0000608)1.80747568
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80165332
141Cellulitis (HP:0100658)1.79900244
142Hepatosplenomegaly (HP:0001433)1.79424408
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79328328
144Basal ganglia calcification (HP:0002135)1.79234906
145Chronic hepatic failure (HP:0100626)1.77931735
146Postaxial foot polydactyly (HP:0001830)1.77880730
147Chronic otitis media (HP:0000389)1.77828917
148Ketosis (HP:0001946)1.77411142
149Aortic dissection (HP:0002647)1.76840080
150Neoplasm of the tracheobronchial system (HP:0100552)1.76387553
151Amyloidosis (HP:0011034)1.76304839
152Azoospermia (HP:0000027)1.76055503
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75995205
154Vertebral compression fractures (HP:0002953)1.75165000
155Conjunctival telangiectasia (HP:0000524)1.74824649
156Prolonged partial thromboplastin time (HP:0003645)1.74538094
157Male pseudohermaphroditism (HP:0000037)1.74505249
158Skin nodule (HP:0200036)1.73409787
159Inability to walk (HP:0002540)1.72101470
160Supernumerary spleens (HP:0009799)1.71454514
161Agammaglobulinemia (HP:0004432)1.70588386
162Fair hair (HP:0002286)1.70536186
163Thick nail (HP:0001805)1.70470277
164Abnormal platelet function (HP:0011869)1.70074545
165Impaired platelet aggregation (HP:0003540)1.70074545
166Epistaxis (HP:0000421)1.69736051
167Recurrent sinusitis (HP:0011108)1.69431493
168Ketoacidosis (HP:0001993)1.69193206
169Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69104488
170Long nose (HP:0003189)1.69006686
171Metaphyseal irregularity (HP:0003025)1.68949679
172Tubulointerstitial fibrosis (HP:0005576)1.68501583
173Abnormal spermatogenesis (HP:0008669)1.68014366
174Abnormality of male internal genitalia (HP:0000022)1.67314444
175Gaze-evoked nystagmus (HP:0000640)1.67132631
176Postaxial hand polydactyly (HP:0001162)1.66235267
177Hip dysplasia (HP:0001385)1.66218541
178Inappropriate behavior (HP:0000719)1.66159167
179Abnormal respiratory epithelium morphology (HP:0012253)1.65306868
180Abnormal respiratory motile cilium morphology (HP:0005938)1.65306868
181IgM deficiency (HP:0002850)1.64530497
182Congenital, generalized hypertrichosis (HP:0004540)1.64388392
183Alveolar cell carcinoma (HP:0006519)1.64055852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.43009518
2TGFBR23.18760140
3ERN12.85376549
4TRIB32.84761472
5ACVR1B2.59781721
6TBK12.52545406
7TYK22.50364387
8PKN22.47527395
9PTK62.47088199
10BLK2.43713669
11BMPR1B2.42854482
12FES2.35883206
13MAP3K142.32014632
14SIK12.22686603
15CAMK1D2.20533911
16CDK122.17454004
17KIT2.09850152
18ERBB32.07839003
19MAP4K11.96845154
20NUAK11.93638524
21TAOK31.89969914
22PINK11.88399814
23FER1.85853191
24WNK31.85481304
25JAK11.83715344
26TNIK1.76140774
27RIPK41.74340925
28FGFR41.70212229
29ZAK1.66731357
30ADRBK21.65265310
31NEK91.65066023
32IRAK31.60679584
33OXSR11.60614508
34MAPK131.58552087
35MAP3K131.54796421
36JAK31.52209370
37PAK41.51929663
38CSF1R1.50685011
39STK101.50035286
40ZAP701.45719041
41CAMK1G1.43532642
42EIF2AK31.42763308
43TTN1.41158948
44CSK1.40385278
45IRAK41.36238592
46FGFR31.34352180
47ITK1.30563281
48PIK3CA1.29443847
49IKBKB1.29273772
50IKBKE1.23792294
51HCK1.23706710
52GRK11.23090464
53STK391.22761948
54FGFR21.19096687
55EPHB11.18965337
56MKNK11.18478934
57TXK1.18399476
58BTK1.18005428
59MKNK21.17813402
60TRPM71.16811427
61CHUK1.14152807
62JAK21.12268485
63CDK61.10683000
64LRRK21.07304550
65MAP3K101.06483559
66RPS6KA41.05025967
67RIPK11.04089585
68MST1R1.03352125
69BMPR21.02554484
70NLK1.01902127
71MAPKAPK31.01664184
72STK31.00889198
73INSRR1.00462169
74LATS10.98243579
75TIE10.98125478
76CAMKK20.97445751
77GRK70.97297394
78DAPK20.97165603
79PLK20.96394323
80MST40.95261006
81MAP3K40.94643407
82CSNK1G20.94450055
83PDGFRA0.92599764
84PRKCE0.91036455
85MAP2K30.90939749
86VRK10.87542664
87FRK0.87203749
88STK38L0.82995305
89LYN0.82577643
90FLT30.82349547
91LCK0.82225697
92EPHA30.79642349
93EPHA20.79269591
94MARK30.78087671
95IRAK10.77590197
96TEC0.77175263
97SYK0.76882245
98BRSK20.75103300
99EGFR0.74844096
100AKT30.74523658
101PIK3CG0.74033983
102TRIM280.73875428
103STK40.73869816
104TGFBR10.72503117
105MAP2K70.72039287
106PIM10.71604532
107CSNK1A1L0.70842708
108PBK0.70829156
109MATK0.69732674
110PLK40.68743317
111MAPKAPK50.68741006
112PDGFRB0.68289922
113BRD40.67698781
114PRKCQ0.67598044
115CSNK1G30.66671155
116PRKAA20.65412102
117PRKG20.64405069
118BCR0.64231330
119EEF2K0.64170773
120STK240.63345097
121ABL10.61697676
122SIK20.61040055
123PTK20.59259064
124MAP2K40.59095040
125CSNK1G10.58344553
126PRKACB0.58118735
127BMX0.57711685
128SGK30.57608799
129IGF1R0.56063248
130MTOR0.55720618
131TNK20.55323647
132FGR0.54079705
133CSNK1A10.53171820
134SCYL20.51047236
135DYRK20.50222926
136GSK3A0.50129002
137ERBB40.47792830
138CCNB10.47576815
139PLK30.47462501
140PRKCH0.46360756
141NEK60.46281071
142CSNK1D0.45587904
143MAPK110.44153094
144ERBB20.42499548
145PDPK10.42275116
146MAP2K60.42199867
147MAPK150.42125741
148ABL20.41882462
149STK110.41473488
150MAP3K80.40840919
151GRK60.40736839
152PRKACA0.40440895
153PRKG10.39908453
154KDR0.39370426
155PDK10.39023920
156MAPKAPK20.39009782
157SRC0.36138956
158PAK20.36078210
159INSR0.35198991
160MAP3K30.33944874
161FYN0.33030222
162CDK90.32780980

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.25879429
2Staphylococcus aureus infection_Homo sapiens_hsa051503.54857291
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.69727083
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65335394
5Complement and coagulation cascades_Homo sapiens_hsa046102.45461057
6Lysosome_Homo sapiens_hsa041422.38522054
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28501122
8Type I diabetes mellitus_Homo sapiens_hsa049402.19744858
9Caffeine metabolism_Homo sapiens_hsa002322.14555751
10Nitrogen metabolism_Homo sapiens_hsa009102.05339223
11Propanoate metabolism_Homo sapiens_hsa006401.99379553
12Leishmaniasis_Homo sapiens_hsa051401.96942990
13Osteoclast differentiation_Homo sapiens_hsa043801.86211838
14Phototransduction_Homo sapiens_hsa047441.85936783
15Butanoate metabolism_Homo sapiens_hsa006501.82554113
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81219593
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.80731922
18Other glycan degradation_Homo sapiens_hsa005111.78573895
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70145832
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.61899728
21Protein export_Homo sapiens_hsa030601.60798074
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52211631
23Primary immunodeficiency_Homo sapiens_hsa053401.46048942
24Pertussis_Homo sapiens_hsa051331.45648943
25Tuberculosis_Homo sapiens_hsa051521.41490578
26Homologous recombination_Homo sapiens_hsa034401.40351908
27Arginine biosynthesis_Homo sapiens_hsa002201.38754733
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38125266
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33868858
30Malaria_Homo sapiens_hsa051441.33474854
31PPAR signaling pathway_Homo sapiens_hsa033201.32926596
32Ether lipid metabolism_Homo sapiens_hsa005651.32513913
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30773253
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26159833
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25623254
36Linoleic acid metabolism_Homo sapiens_hsa005911.23292035
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22843865
38Steroid biosynthesis_Homo sapiens_hsa001001.22565429
39Legionellosis_Homo sapiens_hsa051341.20862642
40Lysine degradation_Homo sapiens_hsa003101.19372568
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.18783449
42Fatty acid elongation_Homo sapiens_hsa000621.18546167
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18288847
44Fatty acid degradation_Homo sapiens_hsa000711.17997898
45ABC transporters_Homo sapiens_hsa020101.16028547
46Toxoplasmosis_Homo sapiens_hsa051451.15279600
47Measles_Homo sapiens_hsa051621.13844763
48Antigen processing and presentation_Homo sapiens_hsa046121.11486222
49Phagosome_Homo sapiens_hsa041451.07638762
50TNF signaling pathway_Homo sapiens_hsa046681.07632545
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07233862
52Histidine metabolism_Homo sapiens_hsa003401.04298678
53Tryptophan metabolism_Homo sapiens_hsa003801.03016942
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.03002207
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01954053
56Apoptosis_Homo sapiens_hsa042100.99933646
57Influenza A_Homo sapiens_hsa051640.99409838
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98674584
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97916952
60RNA degradation_Homo sapiens_hsa030180.97107473
61Selenocompound metabolism_Homo sapiens_hsa004500.96272735
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95839256
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95305269
64Hematopoietic cell lineage_Homo sapiens_hsa046400.95070774
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94580435
66Chronic myeloid leukemia_Homo sapiens_hsa052200.93876838
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92327073
68Starch and sucrose metabolism_Homo sapiens_hsa005000.91211683
69Oxidative phosphorylation_Homo sapiens_hsa001900.90857062
70Amoebiasis_Homo sapiens_hsa051460.90474823
71Collecting duct acid secretion_Homo sapiens_hsa049660.89717581
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.88268166
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88114341
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86768020
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84542939
76Arachidonic acid metabolism_Homo sapiens_hsa005900.83250578
77Insulin resistance_Homo sapiens_hsa049310.81715003
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81551289
79Fat digestion and absorption_Homo sapiens_hsa049750.81290195
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81238985
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80095546
82Hepatitis C_Homo sapiens_hsa051600.79842071
83Pancreatic cancer_Homo sapiens_hsa052120.79226930
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79149653
85Vitamin digestion and absorption_Homo sapiens_hsa049770.78432364
86Peroxisome_Homo sapiens_hsa041460.77637787
87Non-homologous end-joining_Homo sapiens_hsa034500.76916571
88Fatty acid metabolism_Homo sapiens_hsa012120.76308922
89Fanconi anemia pathway_Homo sapiens_hsa034600.75701865
90Graft-versus-host disease_Homo sapiens_hsa053320.75155264
91Small cell lung cancer_Homo sapiens_hsa052220.73574761
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73401832
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73186147
94Bile secretion_Homo sapiens_hsa049760.72535270
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.70252809
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.70125797
97Shigellosis_Homo sapiens_hsa051310.69610310
98Chemical carcinogenesis_Homo sapiens_hsa052040.68718691
99Rheumatoid arthritis_Homo sapiens_hsa053230.67605044
100Hepatitis B_Homo sapiens_hsa051610.67194875
101Salmonella infection_Homo sapiens_hsa051320.65758161
102Ovarian steroidogenesis_Homo sapiens_hsa049130.65702487
103Regulation of autophagy_Homo sapiens_hsa041400.64802372
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64023097
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63984177
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63637862
107beta-Alanine metabolism_Homo sapiens_hsa004100.62189556
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61855303
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61759978
110Acute myeloid leukemia_Homo sapiens_hsa052210.61118607
111Retinol metabolism_Homo sapiens_hsa008300.60876843
112Chemokine signaling pathway_Homo sapiens_hsa040620.60743045
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.60319060
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.59674060
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59141917
116Herpes simplex infection_Homo sapiens_hsa051680.58884289
117Renin-angiotensin system_Homo sapiens_hsa046140.58210963
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56767653
119Prion diseases_Homo sapiens_hsa050200.56649803
120Proteoglycans in cancer_Homo sapiens_hsa052050.56605140
121Platelet activation_Homo sapiens_hsa046110.54741869
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54728254
123Allograft rejection_Homo sapiens_hsa053300.53463423
124Sphingolipid metabolism_Homo sapiens_hsa006000.51795923
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51770437
126Adherens junction_Homo sapiens_hsa045200.50712083
127Focal adhesion_Homo sapiens_hsa045100.50524741
128Glycerolipid metabolism_Homo sapiens_hsa005610.50173872
129Olfactory transduction_Homo sapiens_hsa047400.50060230
130ECM-receptor interaction_Homo sapiens_hsa045120.49748639
131Systemic lupus erythematosus_Homo sapiens_hsa053220.48719628
132Mineral absorption_Homo sapiens_hsa049780.47149555
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46665800
134T cell receptor signaling pathway_Homo sapiens_hsa046600.46564905
135Viral myocarditis_Homo sapiens_hsa054160.46409246
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45771062
137Notch signaling pathway_Homo sapiens_hsa043300.45547596
138Circadian rhythm_Homo sapiens_hsa047100.44891333
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44423915
140Parkinsons disease_Homo sapiens_hsa050120.43084423
141Glutathione metabolism_Homo sapiens_hsa004800.40902213
142Nicotine addiction_Homo sapiens_hsa050330.40569370
143One carbon pool by folate_Homo sapiens_hsa006700.39596880
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38928447
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36199178
146Basal transcription factors_Homo sapiens_hsa030220.35465953
147Taste transduction_Homo sapiens_hsa047420.35384491
148Renin secretion_Homo sapiens_hsa049240.34040555

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