NFYA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)5.31271184
2DNA packaging (GO:0006323)4.93390721
3histone H3-K9 demethylation (GO:0033169)4.21441631
4cytoplasmic mRNA processing body assembly (GO:0033962)4.16998982
5positive regulation of gamma-delta T cell activation (GO:0046645)3.87452139
6regulation of histone H3-K27 methylation (GO:0061085)3.76697956
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73730404
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.73730404
9modulation by symbiont of host immune response (GO:0052553)3.73730404
10positive regulation by symbiont of host defense response (GO:0052509)3.73730404
11modulation by symbiont of host defense response (GO:0052031)3.73730404
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73730404
13nuclear pore complex assembly (GO:0051292)3.64573026
14mitotic sister chromatid cohesion (GO:0007064)3.60385913
15regulation of centriole replication (GO:0046599)3.59978110
16protein localization to kinetochore (GO:0034501)3.50531015
17histone lysine demethylation (GO:0070076)3.45023492
18nucleus organization (GO:0006997)3.41756175
19regulation of nucleobase-containing compound transport (GO:0032239)3.40748465
20histone demethylation (GO:0016577)3.39955612
21DNA conformation change (GO:0071103)3.33499295
22positive regulation of B cell differentiation (GO:0045579)3.28613166
23ribosome assembly (GO:0042255)3.28298528
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26460883
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26460883
26mRNA stabilization (GO:0048255)3.20480748
27RNA stabilization (GO:0043489)3.20480748
28nuclear pore organization (GO:0006999)3.17565080
29protein localization to chromosome, centromeric region (GO:0071459)3.14854608
30regulation of NFAT protein import into nucleus (GO:0051532)3.12816098
31pre-miRNA processing (GO:0031054)3.08425834
32regulation of interferon-beta biosynthetic process (GO:0045357)3.06293057
33negative regulation of histone methylation (GO:0031061)3.05892004
34DNA synthesis involved in DNA repair (GO:0000731)3.03648041
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03472983
36negative regulation of cell killing (GO:0031342)3.03472983
37mitotic chromosome condensation (GO:0007076)3.01619350
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00673615
39antigen processing and presentation of endogenous antigen (GO:0019883)2.99937047
40DNA unwinding involved in DNA replication (GO:0006268)2.99509206
41regulation of gamma-delta T cell differentiation (GO:0045586)2.98911733
42protein dealkylation (GO:0008214)2.98135266
43protein demethylation (GO:0006482)2.98135266
44nucleosome disassembly (GO:0006337)2.97386587
45protein-DNA complex disassembly (GO:0032986)2.97386587
463-UTR-mediated mRNA stabilization (GO:0070935)2.93581411
47negative regulation of DNA repair (GO:0045738)2.89769068
48positive regulation of histone deacetylation (GO:0031065)2.89162138
49regulation of gamma-delta T cell activation (GO:0046643)2.87446529
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87040629
51B cell receptor signaling pathway (GO:0050853)2.86504974
52pore complex assembly (GO:0046931)2.86191645
53spermatid nucleus differentiation (GO:0007289)2.84910921
54negative regulation of phagocytosis (GO:0050765)2.84260400
55mitotic metaphase plate congression (GO:0007080)2.83754063
56regulation of sister chromatid cohesion (GO:0007063)2.82393397
57regulation of chromosome segregation (GO:0051983)2.81265555
58V(D)J recombination (GO:0033151)2.78359300
59mitotic nuclear envelope disassembly (GO:0007077)2.77924065
60heterochromatin organization (GO:0070828)2.77594892
61regulation of interleukin-12 biosynthetic process (GO:0045075)2.75216486
62chromatin silencing (GO:0006342)2.75011637
63protein export from nucleus (GO:0006611)2.74761420
64dosage compensation (GO:0007549)2.73331393
65microtubule depolymerization (GO:0007019)2.72738044
66sister chromatid cohesion (GO:0007062)2.72151702
67positive regulation of interferon-alpha production (GO:0032727)2.71999036
68regulation of histone H3-K9 methylation (GO:0051570)2.70022919
69regulation of transcription from RNA polymerase I promoter (GO:0006356)2.66623076
70B cell homeostasis (GO:0001782)2.66317985
71regulation of RNA export from nucleus (GO:0046831)2.65495667
72regulation of B cell differentiation (GO:0045577)2.65295094
73macrophage activation involved in immune response (GO:0002281)2.64882652
74response to muramyl dipeptide (GO:0032495)2.63537979
75sister chromatid segregation (GO:0000819)2.63412242
76negative regulation of granulocyte differentiation (GO:0030853)2.62824302
77response to peptidoglycan (GO:0032494)2.62675833
78germ cell migration (GO:0008354)2.62447259
79NLS-bearing protein import into nucleus (GO:0006607)2.62333976
80nuclear envelope organization (GO:0006998)2.61835417
81cellular extravasation (GO:0045123)2.61189797
82regulation of mitotic spindle organization (GO:0060236)2.61184968
83negative regulation of gene expression, epigenetic (GO:0045814)2.61133238
84membrane disassembly (GO:0030397)2.61073753
85nuclear envelope disassembly (GO:0051081)2.61073753
86peptidyl-lysine dimethylation (GO:0018027)2.60710910
87alternative mRNA splicing, via spliceosome (GO:0000380)2.58967667
88regulation of interferon-alpha production (GO:0032647)2.57497905
89DNA geometric change (GO:0032392)2.57130609
90glucocorticoid receptor signaling pathway (GO:0042921)2.56933928
91positive regulation of mitotic sister chromatid separation (GO:1901970)2.56599759
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56599759
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56599759
94DNA duplex unwinding (GO:0032508)2.56172604
95DNA topological change (GO:0006265)2.55523271
96hepatocyte apoptotic process (GO:0097284)2.55157438
97regulation of B cell receptor signaling pathway (GO:0050855)2.54663649
98intracellular estrogen receptor signaling pathway (GO:0030520)2.54342478
99corticosteroid receptor signaling pathway (GO:0031958)2.53012475
100single strand break repair (GO:0000012)2.52963110
101immunoglobulin mediated immune response (GO:0016064)2.52866078
102regulation of mRNA stability (GO:0043488)2.52643659
103protein targeting to Golgi (GO:0000042)2.51211736
104regulation of RNA stability (GO:0043487)2.50367578
105NIK/NF-kappaB signaling (GO:0038061)2.50197421
106binding of sperm to zona pellucida (GO:0007339)2.49674192
107negative regulation of histone modification (GO:0031057)2.49181916
108metaphase plate congression (GO:0051310)2.49070246
109histone deubiquitination (GO:0016578)2.48832075
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48750829
111establishment of chromosome localization (GO:0051303)2.48124415
112histone mRNA catabolic process (GO:0071044)2.47531163
113positive regulation of gene expression, epigenetic (GO:0045815)2.47525364
114regulation of DNA endoreduplication (GO:0032875)2.46745648
115histone H2A monoubiquitination (GO:0035518)2.46451040
116retrograde transport, vesicle recycling within Golgi (GO:0000301)2.45212041
117negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.45148970
118response to UV-C (GO:0010225)2.43656394
119positive regulation of chromosome segregation (GO:0051984)2.42620885
120mRNA transport (GO:0051028)2.42251097
121regulation of histone methylation (GO:0031060)2.42227487
122neutrophil activation involved in immune response (GO:0002283)2.41783970
123negative regulation of B cell proliferation (GO:0030889)2.41589975
124chromosome segregation (GO:0007059)2.41365724
125chromatin assembly (GO:0031497)2.41351795
126regulation of chromatin binding (GO:0035561)2.41135406
127histone H4-K16 acetylation (GO:0043984)2.40745550
128positive thymic T cell selection (GO:0045059)2.40716816
129definitive hemopoiesis (GO:0060216)2.40372186
130regulation of sister chromatid segregation (GO:0033045)2.37646581
131regulation of mitotic sister chromatid separation (GO:0010965)2.37646581
132regulation of mitotic sister chromatid segregation (GO:0033047)2.37646581
133regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.37346109
134regulation of integrin activation (GO:0033623)2.37238559
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36484654
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.36484654
137negative regulation of RNA splicing (GO:0033119)2.36402772
138megakaryocyte development (GO:0035855)2.36298028
139mitotic G2 DNA damage checkpoint (GO:0007095)2.35412920
140ER overload response (GO:0006983)2.35412491
141mitotic G2/M transition checkpoint (GO:0044818)2.34442616
142nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34145747
143COPII vesicle coating (GO:0048208)2.33088872
144pinocytosis (GO:0006907)2.32439254
145mitotic sister chromatid segregation (GO:0000070)2.32421468
146negative regulation of mRNA metabolic process (GO:1903312)2.32157721
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.31454776
148lymphocyte homeostasis (GO:0002260)2.30349919
149chromatin assembly or disassembly (GO:0006333)2.29840164
150natural killer cell differentiation (GO:0001779)2.29462997
151T cell apoptotic process (GO:0070231)2.27988484
152natural killer cell mediated immunity (GO:0002228)2.27956593
153natural killer cell mediated cytotoxicity (GO:0042267)2.27956593
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25785011
155response to host (GO:0075136)2.25785011
156response to host defenses (GO:0052200)2.25785011
157histone H3-K36 demethylation (GO:0070544)2.25383746
158neutrophil activation (GO:0042119)2.25012853
159T cell homeostasis (GO:0043029)2.24997072
160protein localization to chromosome (GO:0034502)2.23311493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96301614
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.94585280
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.50764827
4MYC_22102868_ChIP-Seq_BL_Human3.62124424
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34923620
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.98662839
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96002389
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84105567
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83423434
10* VDR_21846776_ChIP-Seq_THP-1_Human2.79153884
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.66209654
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.65634475
13SCL_19346495_ChIP-Seq_HPC-7_Human2.64526815
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57280443
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48876358
16TCF7_22412390_ChIP-Seq_EML_Mouse2.39764670
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38553661
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36173204
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25433959
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.25077844
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23596509
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16421787
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12027834
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.09018314
25MAF_26560356_Chip-Seq_TH1_Human2.05203077
26* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01674556
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98695149
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97424696
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95611379
30* VDR_24763502_ChIP-Seq_THP-1_Human1.94694249
31MYB_26560356_Chip-Seq_TH2_Human1.91518566
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87560266
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85944651
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84398396
35UTX_26944678_Chip-Seq_JUKART_Human1.83789081
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81960571
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.81708447
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78455990
39MYB_26560356_Chip-Seq_TH1_Human1.75189599
40KDM2B_26808549_Chip-Seq_DND41_Human1.74890639
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73580898
42SPI1_23547873_ChIP-Seq_NB4_Human1.70766701
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.68403616
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64373871
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60252392
46SPI1_23127762_ChIP-Seq_K562_Human1.59141164
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.54299790
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52931676
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.52889336
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52017740
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50419460
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50290188
53CIITA_25753668_ChIP-Seq_RAJI_Human1.50137903
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.48514986
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48359223
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47947147
57RUNX_20019798_ChIP-Seq_JUKART_Human1.45716898
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43885681
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41698309
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38403656
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37865217
62AR_21909140_ChIP-Seq_LNCAP_Human1.35906814
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33447189
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32579352
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32554968
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32307816
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31943772
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30740409
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27746359
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26994584
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25920660
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25272045
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23041241
74CLOCK_20551151_ChIP-Seq_293T_Human1.22341890
75PU_27001747_Chip-Seq_BMDM_Mouse1.22247787
76MAF_26560356_Chip-Seq_TH2_Human1.22101572
77* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21718800
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20935786
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19596964
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19425514
81* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16797770
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16491721
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15445187
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14705892
85TFEB_21752829_ChIP-Seq_HELA_Human1.13280174
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11418180
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.10629408
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.09788779
89NCOR1_26117541_ChIP-Seq_K562_Human1.09636897
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06116719
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06088154
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06088154
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05155351
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.04198088
95KDM5A_27292631_Chip-Seq_BREAST_Human1.03787423
96* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02940166
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01796862
98* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99602772
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97963948
100GATA3_27048872_Chip-Seq_THYMUS_Human0.97561441
101MYC_18555785_ChIP-Seq_MESCs_Mouse0.96691024
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95409547
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94562032
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93554647
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91615983
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89938465
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89834978
108* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89668568
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87973555
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87828602
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87736756
112MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87596959
113ATF3_27146783_Chip-Seq_COLON_Human0.87533470
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87319704
115* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86753806
116* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86128375
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84830553
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84779843
119* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83603238
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83368087
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82700851
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82396240
123VDR_24787735_ChIP-Seq_THP-1_Human0.81911229
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81379423
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79434920
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79261627
127GATA6_25053715_ChIP-Seq_YYC3_Human0.78622181
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.76284139
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.75238812
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74373779
131CHD1_26751641_Chip-Seq_LNCaP_Human0.73921925
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73406592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.36721793
2MP0002396_abnormal_hematopoietic_system3.06078643
3MP0005451_abnormal_body_composition3.05568571
4MP0009278_abnormal_bone_marrow2.69379369
5MP0001835_abnormal_antigen_presentation2.55537470
6MP0003303_peritoneal_inflammation2.44445281
7MP0005076_abnormal_cell_differentiation2.42489660
8MP0010352_gastrointestinal_tract_polyps2.41568602
9MP0003300_gastrointestinal_ulcer2.38632562
10MP0004808_abnormal_hematopoietic_stem2.31100691
11MP0005410_abnormal_fertilization2.28969238
12MP0010234_abnormal_vibrissa_follicle2.25847192
13MP0010307_abnormal_tumor_latency2.23954862
14MP0008260_abnormal_autophagy2.23350483
15MP0010094_abnormal_chromosome_stability2.17167299
16MP0003111_abnormal_nucleus_morphology2.12600287
17MP0001800_abnormal_humoral_immune2.06551952
18MP0002009_preneoplasia2.02177663
19MP0003436_decreased_susceptibility_to1.99130538
20MP0001545_abnormal_hematopoietic_system1.96786757
21MP0005397_hematopoietic_system_phenotyp1.96786757
22* MP0003077_abnormal_cell_cycle1.95935404
23MP0003693_abnormal_embryo_hatching1.93620788
24MP0002398_abnormal_bone_marrow1.93212326
25MP0002452_abnormal_antigen_presenting1.92836262
26MP0000685_abnormal_immune_system1.91590520
27MP0002166_altered_tumor_susceptibility1.88746351
28MP0008057_abnormal_DNA_replication1.83832407
29MP0003705_abnormal_hypodermis_morpholog1.81439609
30MP0001790_abnormal_immune_system1.77069961
31MP0005387_immune_system_phenotype1.77069961
32MP0005464_abnormal_platelet_physiology1.70183450
33MP0002420_abnormal_adaptive_immunity1.68989625
34MP0001819_abnormal_immune_cell1.68490987
35MP0005000_abnormal_immune_tolerance1.64462383
36MP0002723_abnormal_immune_serum1.63716059
37MP0003566_abnormal_cell_adhesion1.62762943
38MP0002419_abnormal_innate_immunity1.62278153
39MP0008007_abnormal_cellular_replicative1.61014077
40MP0000703_abnormal_thymus_morphology1.60302039
41MP0000689_abnormal_spleen_morphology1.60257538
42MP0002722_abnormal_immune_system1.56507043
43MP0003763_abnormal_thymus_physiology1.55829646
44MP0000716_abnormal_immune_system1.55698982
45MP0008932_abnormal_embryonic_tissue1.55061790
46MP0004947_skin_inflammation1.52302268
47MP0000490_abnormal_crypts_of1.51035560
48MP0002405_respiratory_system_inflammati1.49965784
49MP0002006_tumorigenesis1.49375606
50MP0009697_abnormal_copulation1.46276676
51MP0005174_abnormal_tail_pigmentation1.44621466
52MP0003656_abnormal_erythrocyte_physiolo1.44485185
53MP0004233_abnormal_muscle_weight1.41708322
54MP0002429_abnormal_blood_cell1.41002734
55MP0005025_abnormal_response_to1.40284087
56* MP0000350_abnormal_cell_proliferation1.40096743
57MP0004510_myositis1.39044755
58MP0003172_abnormal_lysosome_physiology1.37043232
59MP0005671_abnormal_response_to1.35597219
60MP0004957_abnormal_blastocyst_morpholog1.34209334
61MP0001873_stomach_inflammation1.33626167
62MP0000465_gastrointestinal_hemorrhage1.31761633
63MP0010155_abnormal_intestine_physiology1.26218197
64MP0009333_abnormal_splenocyte_physiolog1.26185477
65MP0002796_impaired_skin_barrier1.26099440
66MP0003448_altered_tumor_morphology1.22384653
67MP0000733_abnormal_muscle_development1.21472389
68MP0003221_abnormal_cardiomyocyte_apopto1.20026863
69MP0005058_abnormal_lysosome_morphology1.18486219
70MP0002019_abnormal_tumor_incidence1.18025866
71MP0001929_abnormal_gametogenesis1.18019695
72MP0001730_embryonic_growth_arrest1.17320338
73MP0005409_darkened_coat_color1.15776612
74MP0009785_altered_susceptibility_to1.14063014
75MP0001915_intracranial_hemorrhage1.13233930
76MP0002086_abnormal_extraembryonic_tissu1.13021086
77MP0005380_embryogenesis_phenotype1.08363285
78MP0001672_abnormal_embryogenesis/_devel1.08363285
79MP0003984_embryonic_growth_retardation1.08316366
80MP0009672_abnormal_birth_weight1.07928334
81MP0002877_abnormal_melanocyte_morpholog1.07868975
82MP0002088_abnormal_embryonic_growth/wei1.07138797
83MP0000858_altered_metastatic_potential1.06323354
84MP0006082_CNS_inflammation1.05964011
85MP0003191_abnormal_cellular_cholesterol1.05138825
86MP0001216_abnormal_epidermal_layer1.03296534
87MP0002148_abnormal_hypersensitivity_rea1.02769701
88MP0001845_abnormal_inflammatory_respons1.01553411
89MP0005384_cellular_phenotype1.00185670
90MP0005023_abnormal_wound_healing1.00141712
91MP0006054_spinal_hemorrhage0.99362044
92MP0002060_abnormal_skin_morphology0.99213296
93MP0000371_diluted_coat_color0.98674183
94MP0003091_abnormal_cell_migration0.98557450
95MP0004381_abnormal_hair_follicle0.98505932
96MP0004197_abnormal_fetal_growth/weight/0.96304428
97MP0003698_abnormal_male_reproductive0.96249819
98MP0003828_pulmonary_edema0.96167196
99MP0001849_ear_inflammation0.95365634
100MP0003115_abnormal_respiratory_system0.95303977
101MP0005666_abnormal_adipose_tissue0.94865994
102* MP0000313_abnormal_cell_death0.94267105
103MP0001697_abnormal_embryo_size0.93538963
104MP0005310_abnormal_salivary_gland0.93340178
105MP0003787_abnormal_imprinting0.88851020
106MP0005257_abnormal_intraocular_pressure0.86507510
107MP0003567_abnormal_fetal_cardiomyocyte0.86197536
108MP0001533_abnormal_skeleton_physiology0.85905247
109MP0004185_abnormal_adipocyte_glucose0.85840482
110MP0001853_heart_inflammation0.85259921
111MP0003890_abnormal_embryonic-extraembry0.84650145
112* MP0002080_prenatal_lethality0.84283166
113MP0004264_abnormal_extraembryonic_tissu0.84205061
114MP0001851_eye_inflammation0.83458226
115MP0000015_abnormal_ear_pigmentation0.83172773
116MP0005621_abnormal_cell_physiology0.83001902
117MP0002084_abnormal_developmental_patter0.82743362
118MP0003718_maternal_effect0.82595433
119MP0008961_abnormal_basal_metabolism0.81981876
120MP0000678_abnormal_parathyroid_gland0.80958853
121MP0008058_abnormal_DNA_repair0.80495006
122MP0002085_abnormal_embryonic_tissue0.79307373
123MP0000537_abnormal_urethra_morphology0.79193477
124MP0002925_abnormal_cardiovascular_devel0.78842020
125MP0003943_abnormal_hepatobiliary_system0.78625894
126MP0003121_genomic_imprinting0.78566721
127MP0003453_abnormal_keratinocyte_physiol0.77488581
128MP0009703_decreased_birth_body0.76488214
129MP0001340_abnormal_eyelid_morphology0.75059007
130MP0003950_abnormal_plasma_membrane0.73395304
131MP0005501_abnormal_skin_physiology0.72711644
132MP0003724_increased_susceptibility_to0.72063682

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.56543634
2Asymmetry of the thorax (HP:0001555)3.34602791
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.31154321
4Recurrent abscess formation (HP:0002722)3.27122892
5Papillary thyroid carcinoma (HP:0002895)3.26245486
6Recurrent bacterial skin infections (HP:0005406)3.12994536
7Cellulitis (HP:0100658)3.10567561
8Recurrent viral infections (HP:0004429)3.04638168
9Chromsome breakage (HP:0040012)2.92545824
10Recurrent fungal infections (HP:0002841)2.78179308
11Hyperacusis (HP:0010780)2.73777377
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66122595
13Termporal pattern (HP:0011008)2.63079135
14Insidious onset (HP:0003587)2.63079135
15Eczematoid dermatitis (HP:0000976)2.62111191
16Disinhibition (HP:0000734)2.52161707
17Mediastinal lymphadenopathy (HP:0100721)2.47032016
18Viral hepatitis (HP:0006562)2.46157609
19Hematochezia (HP:0002573)2.44771058
20Volvulus (HP:0002580)2.44261639
21Acute myeloid leukemia (HP:0004808)2.41239651
22Spinal cord lesions (HP:0100561)2.40559234
23Syringomyelia (HP:0003396)2.40559234
24Nephroblastoma (Wilms tumor) (HP:0002667)2.40267894
25Transitional cell carcinoma of the bladder (HP:0006740)2.39880524
26Overlapping toe (HP:0001845)2.34222284
27Progressive sensorineural hearing impairment (HP:0000408)2.34112618
28Short 4th metacarpal (HP:0010044)2.30894909
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30894909
30Increased density of long bones (HP:0006392)2.30893797
31Periodontitis (HP:0000704)2.30610466
32Long eyelashes (HP:0000527)2.29584424
33Cerebral aneurysm (HP:0004944)2.29096277
34Ectopic kidney (HP:0000086)2.28908226
35Absent frontal sinuses (HP:0002688)2.27569045
36Autoimmune thrombocytopenia (HP:0001973)2.26136000
37Bladder neoplasm (HP:0009725)2.25690408
38Bladder carcinoma (HP:0002862)2.25690408
39Proximal placement of thumb (HP:0009623)2.22903035
40Spontaneous hematomas (HP:0007420)2.22851249
41Osteomyelitis (HP:0002754)2.22373764
42Chronic otitis media (HP:0000389)2.21789184
43Long palpebral fissure (HP:0000637)2.21351586
44Thyroid carcinoma (HP:0002890)2.20712106
45Embryonal renal neoplasm (HP:0011794)2.20051501
46Leiomyosarcoma (HP:0100243)2.19125029
47Uterine leiomyosarcoma (HP:0002891)2.19125029
48Increased nuchal translucency (HP:0010880)2.16786875
49IgM deficiency (HP:0002850)2.13646219
50Progressive hearing impairment (HP:0001730)2.13581649
51Cystic hygroma (HP:0000476)2.12094932
52Colitis (HP:0002583)2.09843337
53Deep palmar crease (HP:0006191)2.09369004
54Prominent nose (HP:0000448)2.08670170
55High anterior hairline (HP:0009890)2.08178120
56Abnormal foot bone ossification (HP:0010675)2.07328167
57Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06979726
58Relative macrocephaly (HP:0004482)2.04524508
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.03950966
60Recurrent bronchitis (HP:0002837)2.02603243
61Truncal obesity (HP:0001956)2.02329124
62Ankyloglossia (HP:0010296)2.01305948
63Agammaglobulinemia (HP:0004432)2.00174676
64Papilloma (HP:0012740)1.99221543
65Verrucae (HP:0200043)1.99221543
66Cone-rod dystrophy (HP:0000548)1.99069117
67Flared metaphyses (HP:0003015)1.98861765
68Recurrent skin infections (HP:0001581)1.97508573
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97304743
70Increased cerebral lipofuscin (HP:0011813)1.96891108
71Osteolytic defects of the hand bones (HP:0009699)1.96732155
72Osteolytic defects of the phalanges of the hand (HP:0009771)1.96732155
73Vertebral arch anomaly (HP:0008438)1.96588346
74Thrombocytosis (HP:0001894)1.96438040
75Myositis (HP:0100614)1.96052665
76Cortical dysplasia (HP:0002539)1.94909663
77Abnormality of chromosome segregation (HP:0002916)1.94687713
78Menstrual irregularities (HP:0000858)1.93940898
79High pitched voice (HP:0001620)1.93747059
80Sandal gap (HP:0001852)1.92673366
81Inflammation of the large intestine (HP:0002037)1.91892583
82Obsessive-compulsive behavior (HP:0000722)1.91383310
83Panhypogammaglobulinemia (HP:0003139)1.91305219
84Gastrointestinal inflammation (HP:0004386)1.90317814
85Dislocated radial head (HP:0003083)1.89957762
86Reticulocytopenia (HP:0001896)1.87979306
87Thyroiditis (HP:0100646)1.87388859
88Diastasis recti (HP:0001540)1.87310547
89Ulnar bowing (HP:0003031)1.87201260
90Meningitis (HP:0001287)1.86637352
91Pustule (HP:0200039)1.86457138
92Renal cell carcinoma (HP:0005584)1.86302953
93Spondylolisthesis (HP:0003302)1.86082155
94Agnosia (HP:0010524)1.85808906
95Resting tremor (HP:0002322)1.85671018
96Bicuspid aortic valve (HP:0001647)1.85374304
97Decreased skull ossification (HP:0004331)1.85071632
98Acute lymphatic leukemia (HP:0006721)1.84559733
99Persistence of primary teeth (HP:0006335)1.84304953
100Cutis marmorata (HP:0000965)1.84166725
101Fatigue (HP:0012378)1.84158597
102Small epiphyses (HP:0010585)1.84150985
103Prolonged bleeding time (HP:0003010)1.84061316
104Skull defect (HP:0001362)1.83199643
105Elfin facies (HP:0004428)1.79634421
106Myelodysplasia (HP:0002863)1.79514351
107T lymphocytopenia (HP:0005403)1.79124408
108Flattened epiphyses (HP:0003071)1.78415752
109Abnormality of chromosome stability (HP:0003220)1.76351672
110Recurrent cutaneous fungal infections (HP:0011370)1.75663394
111Chronic mucocutaneous candidiasis (HP:0002728)1.75663394
112Abnormality of the thymus (HP:0000777)1.75586331
113Heterotopia (HP:0002282)1.75013381
114Elevated erythrocyte sedimentation rate (HP:0003565)1.74842645
115Leukocytosis (HP:0001974)1.74599892
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.74480831
117Chronic obstructive pulmonary disease (HP:0006510)1.73829304
118Obstructive lung disease (HP:0006536)1.73829304
119Limited elbow extension (HP:0001377)1.73521257
120Abnormal platelet volume (HP:0011876)1.73301004
121Macroorchidism (HP:0000053)1.73064023
122Anal stenosis (HP:0002025)1.72710435
123Curly hair (HP:0002212)1.72584046
124Cutaneous melanoma (HP:0012056)1.71982366
125Gastrointestinal carcinoma (HP:0002672)1.71835622
126Malignant gastrointestinal tract tumors (HP:0006749)1.71835622
127Clubbing of toes (HP:0100760)1.71069164
128Renovascular hypertension (HP:0100817)1.70659454
129Gingivitis (HP:0000230)1.70309501
130Neonatal hypoglycemia (HP:0001998)1.70288071
131Arterial thrombosis (HP:0004420)1.70220443
132Nasal polyposis (HP:0100582)1.69844347
133Deep philtrum (HP:0002002)1.69330148
134Metaphyseal cupping (HP:0003021)1.68910517
135Aortic aneurysm (HP:0004942)1.67969594
136Abnormality of T cell number (HP:0011839)1.67806817
137Abnormal platelet function (HP:0011869)1.67447268
138Impaired platelet aggregation (HP:0003540)1.67447268
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67417123
140Narrow palate (HP:0000189)1.65789525
141Medulloblastoma (HP:0002885)1.65597440
142Eosinophilia (HP:0001880)1.65431462
143Abnormality of the 4th metacarpal (HP:0010012)1.65133176
144Abnormality of the carotid arteries (HP:0005344)1.63921560
145Abnormality of the radial head (HP:0003995)1.63445897
146Male infertility (HP:0003251)1.63420377
147Somatic mutation (HP:0001428)1.62883571
148Renal duplication (HP:0000075)1.62822131
149Cafe-au-lait spot (HP:0000957)1.62768183
150Urethral obstruction (HP:0000796)1.61828666
151Deviation of the thumb (HP:0009603)1.61209798
152Abnormality of oral frenula (HP:0000190)1.59749260
153Mitral valve prolapse (HP:0001634)1.58596010
154Disproportionate tall stature (HP:0001519)1.58211566
155Upper motor neuron abnormality (HP:0002127)1.57762281
156Hepatitis (HP:0012115)1.57686314
157Abnormality of skull ossification (HP:0002703)1.57448296
158Orthostatic hypotension (HP:0001278)1.57311099
159Subacute progressive viral hepatitis (HP:0006572)1.57235436
160Abnormality of B cell number (HP:0010975)1.57183239
161B lymphocytopenia (HP:0010976)1.57183239
162Micronodular cirrhosis (HP:0001413)1.55672566
163Slow saccadic eye movements (HP:0000514)1.54161223
164Blepharitis (HP:0000498)1.53002543
165Hypoplasia of the thymus (HP:0000778)1.51660251
166Pelvic girdle muscle weakness (HP:0003749)1.49384321
167Glossoptosis (HP:0000162)1.48256363
168Omphalocele (HP:0001539)1.48102300
169Aplasia/Hypoplasia of the earlobes (HP:0009906)1.46834770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.83565573
2PLK43.55895782
3CDK123.41460569
4MAP4K12.82938430
5MAP3K102.82635559
6PRPF4B2.62005779
7TRIB32.55119893
8SRPK12.51924892
9PKN22.27773545
10CDC72.26865842
11STK102.16687409
12PNCK1.93544590
13SMG11.93206641
14NEK21.92337284
15KIT1.87302793
16TAOK31.86497412
17SIK31.80600513
18SCYL21.77429887
19BRSK21.73450987
20CSF1R1.70487374
21TYK21.69775653
22JAK31.60738953
23YES11.54044461
24CDK61.53431559
25TGFBR21.52090703
26CAMK1D1.48085136
27MKNK21.44106929
28ERN11.42087823
29RPS6KA41.39234464
30AKT31.38090455
31MAP3K141.36996709
32STK31.36225482
33EIF2AK31.34074782
34CDK41.33872259
35LATS11.31441427
36SIK21.29978326
37PTK61.29211624
38BTK1.27750282
39RPS6KB21.26950910
40BRD41.26577047
41TTN1.25772256
42FGR1.22016863
43STK41.21852156
44CHUK1.20242787
45ZAP701.19890312
46MARK31.19739534
47LRRK21.19160180
48PIM11.16316676
49WNK11.14106999
50FLT31.13855840
51BLK1.11306836
52HCK1.09811440
53TBK11.09614991
54ALK1.09187515
55ATR1.09013420
56GRK61.08311318
57CAMK1G1.07288126
58IRAK31.07115236
59FGFR31.04655063
60RIPK11.04271910
61LATS21.01811858
62TAF11.01652963
63PAK41.00849858
64MTOR0.99168082
65IKBKB0.98800023
66JAK10.98309098
67TAOK20.95800565
68MAP3K80.94199762
69MAP3K20.93241104
70MET0.93141161
71TYRO30.91921171
72SYK0.91413290
73BUB10.88937950
74CLK10.88684801
75KSR10.88550784
76CHEK20.87708638
77CDK90.87125829
78TRPM70.86357288
79MAP2K30.84980948
80DDR20.84253863
81BRAF0.83812838
82CDK80.83682396
83IRAK40.83276507
84CHEK10.81957734
85CSK0.81324848
86TTK0.79997375
87IKBKE0.79356262
88EPHB10.79037687
89TSSK60.77706908
90LCK0.73718047
91CDK70.72989829
92KSR20.68891098
93BRSK10.68818134
94TAOK10.68422717
95PLK20.67379263
96TGFBR10.66192136
97PAK20.66064788
98PDGFRB0.65051374
99NEK90.64746248
100MAP3K60.63397305
101DMPK0.63043019
102MAP3K10.63023200
103JAK20.62877064
104IRAK20.62711071
105ITK0.62517388
106ATM0.62413677
107PASK0.62150782
108AURKB0.61158527
109FGFR20.60918384
110PLK30.60442750
111MAP3K90.60138770
112TXK0.59713075
113MKNK10.57285928
114CDK10.57007591
115TEC0.56974309
116MAP3K30.56694143
117DYRK1B0.55693325
118LYN0.55472772
119* CDK20.54904730
120WEE10.54891993
121MELK0.54852752
122DYRK30.54645376
123RIPK40.54431441
124ICK0.54011526
125BMX0.53670010
126MAPKAPK20.53599667
127MST1R0.51809430
128MAP3K130.49705826
129SGK30.48892716
130RET0.48324276
131EPHA30.48193216
132MAPK100.46957264
133PLK10.46744321
134EGFR0.46602244
135ABL10.46352860
136IRAK10.46198580
137SIK10.45678332
138BCR0.45345988
139PTK20.45100874
140FGFR40.44382779
141MAPKAPK30.43349844
142HIPK20.42393506
143RPS6KA10.42165600
144PDGFRA0.40693862

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.21776918
2Chronic myeloid leukemia_Homo sapiens_hsa052201.99288746
3Leishmaniasis_Homo sapiens_hsa051401.98947060
4Osteoclast differentiation_Homo sapiens_hsa043801.93702084
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.82260714
6Thyroid cancer_Homo sapiens_hsa052161.81125708
7DNA replication_Homo sapiens_hsa030301.72522473
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69034789
9Cell cycle_Homo sapiens_hsa041101.66476769
10Primary immunodeficiency_Homo sapiens_hsa053401.65733237
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64966124
12Measles_Homo sapiens_hsa051621.62140420
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58076619
14Small cell lung cancer_Homo sapiens_hsa052221.53698336
15Pancreatic cancer_Homo sapiens_hsa052121.52822803
16MicroRNAs in cancer_Homo sapiens_hsa052061.51123068
17Herpes simplex infection_Homo sapiens_hsa051681.50696041
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49623836
19Toxoplasmosis_Homo sapiens_hsa051451.48694882
20Acute myeloid leukemia_Homo sapiens_hsa052211.44290823
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41356904
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37996026
23Apoptosis_Homo sapiens_hsa042101.37216804
24Hepatitis B_Homo sapiens_hsa051611.36742896
25* Antigen processing and presentation_Homo sapiens_hsa046121.34663371
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31511504
27Non-small cell lung cancer_Homo sapiens_hsa052231.30972228
28Base excision repair_Homo sapiens_hsa034101.30075938
29Influenza A_Homo sapiens_hsa051641.28493743
30Hematopoietic cell lineage_Homo sapiens_hsa046401.27511037
31Colorectal cancer_Homo sapiens_hsa052101.24067337
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23352056
33Mismatch repair_Homo sapiens_hsa034301.21766021
34Shigellosis_Homo sapiens_hsa051311.21463856
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21295265
36ErbB signaling pathway_Homo sapiens_hsa040121.20283945
37Lysine degradation_Homo sapiens_hsa003101.19683441
38T cell receptor signaling pathway_Homo sapiens_hsa046601.19269722
39Viral myocarditis_Homo sapiens_hsa054161.19161640
40Viral carcinogenesis_Homo sapiens_hsa052031.18216245
41TNF signaling pathway_Homo sapiens_hsa046681.16289469
42Non-homologous end-joining_Homo sapiens_hsa034501.16008841
43HTLV-I infection_Homo sapiens_hsa051661.15492011
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14973817
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14020700
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.13721020
47p53 signaling pathway_Homo sapiens_hsa041151.12786826
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.11876281
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.11480289
50mTOR signaling pathway_Homo sapiens_hsa041501.10512221
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.10477398
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.10024067
53Notch signaling pathway_Homo sapiens_hsa043301.09888235
54* Tuberculosis_Homo sapiens_hsa051521.09647084
55Staphylococcus aureus infection_Homo sapiens_hsa051501.08299341
56Platelet activation_Homo sapiens_hsa046111.06057037
57RNA transport_Homo sapiens_hsa030131.05919470
58Legionellosis_Homo sapiens_hsa051341.05909195
59mRNA surveillance pathway_Homo sapiens_hsa030151.04228880
60Pertussis_Homo sapiens_hsa051331.03843247
61Homologous recombination_Homo sapiens_hsa034401.02313127
62Spliceosome_Homo sapiens_hsa030401.02202684
63Chemokine signaling pathway_Homo sapiens_hsa040621.01667092
64Epstein-Barr virus infection_Homo sapiens_hsa051691.00944297
65One carbon pool by folate_Homo sapiens_hsa006701.00697755
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00568747
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99309036
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95247884
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94644270
70Fanconi anemia pathway_Homo sapiens_hsa034600.93860614
71Endometrial cancer_Homo sapiens_hsa052130.93674016
72Prolactin signaling pathway_Homo sapiens_hsa049170.91874974
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91117419
74Adherens junction_Homo sapiens_hsa045200.90843536
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90422787
76Proteoglycans in cancer_Homo sapiens_hsa052050.89926318
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.89621509
78Malaria_Homo sapiens_hsa051440.86165093
79Prostate cancer_Homo sapiens_hsa052150.83761057
80VEGF signaling pathway_Homo sapiens_hsa043700.82951746
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82393117
82FoxO signaling pathway_Homo sapiens_hsa040680.81420402
83Glioma_Homo sapiens_hsa052140.80803118
84Renal cell carcinoma_Homo sapiens_hsa052110.77556885
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76762217
86RNA degradation_Homo sapiens_hsa030180.75379287
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74544514
88Fatty acid biosynthesis_Homo sapiens_hsa000610.72996283
89Focal adhesion_Homo sapiens_hsa045100.72813793
90HIF-1 signaling pathway_Homo sapiens_hsa040660.72457515
91Choline metabolism in cancer_Homo sapiens_hsa052310.70961622
92Hepatitis C_Homo sapiens_hsa051600.70388645
93Other glycan degradation_Homo sapiens_hsa005110.69283607
94Salmonella infection_Homo sapiens_hsa051320.69208328
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68335647
96Oocyte meiosis_Homo sapiens_hsa041140.67947055
97Pathways in cancer_Homo sapiens_hsa052000.66491489
98Insulin signaling pathway_Homo sapiens_hsa049100.66006230
99Basal transcription factors_Homo sapiens_hsa030220.65864746
100Estrogen signaling pathway_Homo sapiens_hsa049150.64309101
101Lysosome_Homo sapiens_hsa041420.63384778
102Insulin resistance_Homo sapiens_hsa049310.63356048
103Dorso-ventral axis formation_Homo sapiens_hsa043200.62894785
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.61497723
105Endocytosis_Homo sapiens_hsa041440.61458949
106Amoebiasis_Homo sapiens_hsa051460.59948844
107Melanoma_Homo sapiens_hsa052180.59754376
108African trypanosomiasis_Homo sapiens_hsa051430.59006350
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58678788
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58232326
111Bladder cancer_Homo sapiens_hsa052190.56812636
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53839637
113Sphingolipid metabolism_Homo sapiens_hsa006000.53284227
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53188104
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52514453
116Nucleotide excision repair_Homo sapiens_hsa034200.52114621
117Inositol phosphate metabolism_Homo sapiens_hsa005620.51350179
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51037566
119Systemic lupus erythematosus_Homo sapiens_hsa053220.50922695

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