NFS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.95797019
2lysine catabolic process (GO:0006554)5.95797019
3L-phenylalanine metabolic process (GO:0006558)5.37583797
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.37583797
5L-phenylalanine catabolic process (GO:0006559)5.34006383
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.34006383
7glyoxylate metabolic process (GO:0046487)5.08470936
8* cysteine metabolic process (GO:0006534)5.06664434
9piRNA metabolic process (GO:0034587)5.00417524
10aromatic amino acid family catabolic process (GO:0009074)4.75765715
11amino-acid betaine metabolic process (GO:0006577)4.72630154
122-oxoglutarate metabolic process (GO:0006103)4.69777484
13male meiosis I (GO:0007141)4.68078320
14synapsis (GO:0007129)4.66663485
15kynurenine metabolic process (GO:0070189)4.54846367
16valine metabolic process (GO:0006573)4.54478897
17serine family amino acid catabolic process (GO:0009071)4.51890335
18aspartate family amino acid catabolic process (GO:0009068)4.44658098
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.44615606
20bile acid biosynthetic process (GO:0006699)4.36849615
21sulfur amino acid catabolic process (GO:0000098)4.36751394
22behavioral response to nicotine (GO:0035095)4.36428966
23tricarboxylic acid cycle (GO:0006099)4.35496449
24tryptophan catabolic process (GO:0006569)4.35137636
25indole-containing compound catabolic process (GO:0042436)4.35137636
26indolalkylamine catabolic process (GO:0046218)4.35137636
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.28200796
28fatty acid beta-oxidation (GO:0006635)4.27510842
29glycine metabolic process (GO:0006544)4.26929191
30carnitine metabolic process (GO:0009437)4.25027598
31cellular ketone body metabolic process (GO:0046950)4.24085611
32DNA methylation involved in gamete generation (GO:0043046)4.22544707
33homocysteine metabolic process (GO:0050667)4.22189767
34tryptophan metabolic process (GO:0006568)4.17088454
35* serine family amino acid metabolic process (GO:0009069)4.14808097
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14165988
37serine family amino acid biosynthetic process (GO:0009070)4.08683972
38short-chain fatty acid metabolic process (GO:0046459)4.06377794
39alpha-linolenic acid metabolic process (GO:0036109)4.05808882
40ethanol oxidation (GO:0006069)4.05326091
41acetyl-CoA metabolic process (GO:0006084)4.04284973
42tricarboxylic acid metabolic process (GO:0072350)4.04120799
43branched-chain amino acid catabolic process (GO:0009083)4.04072884
44ubiquinone biosynthetic process (GO:0006744)4.02659430
45fatty acid oxidation (GO:0019395)3.99913825
46branched-chain amino acid metabolic process (GO:0009081)3.95603066
47chromosome organization involved in meiosis (GO:0070192)3.94100788
48urea cycle (GO:0000050)3.93099886
49urea metabolic process (GO:0019627)3.93099886
50lipid oxidation (GO:0034440)3.92375129
51alpha-amino acid catabolic process (GO:1901606)3.91181564
52oxaloacetate metabolic process (GO:0006107)3.87586071
53fatty acid catabolic process (GO:0009062)3.86800328
54urate metabolic process (GO:0046415)3.84719019
55meiosis I (GO:0007127)3.82548563
56NADH metabolic process (GO:0006734)3.81545715
57ATP synthesis coupled proton transport (GO:0015986)3.79547973
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79547973
59nitrogen cycle metabolic process (GO:0071941)3.71867685
60cellular amino acid catabolic process (GO:0009063)3.71843781
61monocarboxylic acid catabolic process (GO:0072329)3.70788267
62regulation of triglyceride catabolic process (GO:0010896)3.65732276
63ketone body metabolic process (GO:1902224)3.63830258
64folic acid metabolic process (GO:0046655)3.62123640
65aromatic amino acid family metabolic process (GO:0009072)3.58959053
66cellular modified amino acid catabolic process (GO:0042219)3.57904288
67carboxylic acid catabolic process (GO:0046395)3.57647696
68organic acid catabolic process (GO:0016054)3.57647696
69drug transmembrane transport (GO:0006855)3.56267412
70bile acid metabolic process (GO:0008206)3.55769836
71fatty acid transmembrane transport (GO:1902001)3.53717570
72ubiquinone metabolic process (GO:0006743)3.52075752
73quinone biosynthetic process (GO:1901663)3.51429241
74water-soluble vitamin biosynthetic process (GO:0042364)3.50899228
75synaptonemal complex assembly (GO:0007130)3.50686451
76regulation of protein activation cascade (GO:2000257)3.47608941
77succinate metabolic process (GO:0006105)3.47546045
78negative regulation of fibrinolysis (GO:0051918)3.47348160
79preassembly of GPI anchor in ER membrane (GO:0016254)3.46018431
80carnitine shuttle (GO:0006853)3.41726840
81meiotic chromosome segregation (GO:0045132)3.41436431
82aldehyde catabolic process (GO:0046185)3.38036301
83reciprocal meiotic recombination (GO:0007131)3.36645689
84reciprocal DNA recombination (GO:0035825)3.36645689
85drug transport (GO:0015893)3.35178267
86biotin metabolic process (GO:0006768)3.33749651
87oxidative phosphorylation (GO:0006119)3.32244267
88high-density lipoprotein particle remodeling (GO:0034375)3.31997205
89pseudouridine synthesis (GO:0001522)3.30659366
90complement activation, alternative pathway (GO:0006957)3.28958043
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.28860963
92NADH dehydrogenase complex assembly (GO:0010257)3.28860963
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28860963
94dicarboxylic acid metabolic process (GO:0043648)3.28815894
95regulation of complement activation (GO:0030449)3.28664547
96nucleoside transmembrane transport (GO:1901642)3.27965362
97response to mercury ion (GO:0046689)3.27458866
98glutamate metabolic process (GO:0006536)3.26744507
99NAD metabolic process (GO:0019674)3.26016957
100synaptonemal complex organization (GO:0070193)3.24695515
101coenzyme catabolic process (GO:0009109)3.22092518
102peptidyl-glutamic acid carboxylation (GO:0017187)3.21396242
103protein carboxylation (GO:0018214)3.21396242
104drug catabolic process (GO:0042737)3.21172648
105triglyceride homeostasis (GO:0070328)3.19481054
106acylglycerol homeostasis (GO:0055090)3.19481054
107regulation of nuclear cell cycle DNA replication (GO:0033262)3.18099432
108dicarboxylic acid biosynthetic process (GO:0043650)3.17193088
109regulation of cholesterol metabolic process (GO:0090181)3.15265659
110regulation of fibrinolysis (GO:0051917)3.14520681
111cellular glucuronidation (GO:0052695)3.13580591
112one-carbon metabolic process (GO:0006730)3.13132526
113benzene-containing compound metabolic process (GO:0042537)3.11381112
114fructose metabolic process (GO:0006000)3.09794252
115tyrosine metabolic process (GO:0006570)3.09409761
116aspartate family amino acid metabolic process (GO:0009066)3.09351136
117* sulfur amino acid metabolic process (GO:0000096)3.09051785
118carnitine transport (GO:0015879)3.08042946
119amino-acid betaine transport (GO:0015838)3.08042946
120oxidative demethylation (GO:0070989)3.07481773
121pyridine nucleotide biosynthetic process (GO:0019363)3.05465453
122nicotinamide nucleotide biosynthetic process (GO:0019359)3.05465453
123respiratory chain complex IV assembly (GO:0008535)3.04640759
124L-serine metabolic process (GO:0006563)3.03645860
125primary amino compound metabolic process (GO:1901160)3.02849739
126small molecule catabolic process (GO:0044282)3.01893626
127electron transport chain (GO:0022900)3.01333023
128protein-lipid complex remodeling (GO:0034368)2.99744504
129macromolecular complex remodeling (GO:0034367)2.99744504
130plasma lipoprotein particle remodeling (GO:0034369)2.99744504
131male meiosis (GO:0007140)2.98189004
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97229896
133meiotic nuclear division (GO:0007126)2.94694822
134respiratory electron transport chain (GO:0022904)2.93580185
135positive regulation of fatty acid transport (GO:2000193)2.91413180
136L-methionine salvage (GO:0071267)2.89372033
137L-methionine biosynthetic process (GO:0071265)2.89372033
138amino acid salvage (GO:0043102)2.89372033
139nucleotide transmembrane transport (GO:1901679)2.87492516
140protein complex biogenesis (GO:0070271)2.87013130
141protein import into peroxisome matrix (GO:0016558)2.83121704
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82913197
143mitochondrial respiratory chain complex assembly (GO:0033108)2.81011299
144positive regulation of prostaglandin secretion (GO:0032308)2.72454553
145regulation of triglyceride biosynthetic process (GO:0010866)2.69755993
146mannosylation (GO:0097502)2.68678392
147positive regulation of icosanoid secretion (GO:0032305)2.68122895
148protein K6-linked ubiquitination (GO:0085020)2.68042767
149ATP biosynthetic process (GO:0006754)2.64217434
150gamma-aminobutyric acid transport (GO:0015812)2.62615857
151fucose catabolic process (GO:0019317)2.60905335
152L-fucose metabolic process (GO:0042354)2.60905335
153L-fucose catabolic process (GO:0042355)2.60905335
154tRNA modification (GO:0006400)2.58593470
155neuronal action potential (GO:0019228)2.57767186
156exogenous drug catabolic process (GO:0042738)2.57196909
157mitochondrial RNA metabolic process (GO:0000959)2.56721537
158meiotic cell cycle process (GO:1903046)2.56438556
159negative regulation of telomere maintenance (GO:0032205)2.55970317
160positive regulation of triglyceride biosynthetic process (GO:0010867)2.54388076
161cornea development in camera-type eye (GO:0061303)2.52234484
162proteasome assembly (GO:0043248)2.50996626
163regulation of mitochondrial translation (GO:0070129)2.49930838
164quinone metabolic process (GO:1901661)2.48306103
165negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47353325
166protein-cofactor linkage (GO:0018065)2.45931020
167GPI anchor metabolic process (GO:0006505)2.45086715
168tRNA methylation (GO:0030488)2.44721072
169detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43918217
170resolution of meiotic recombination intermediates (GO:0000712)2.43374654
171DNA replication checkpoint (GO:0000076)2.43259813
172viral transcription (GO:0019083)2.43132305
173maturation of 5.8S rRNA (GO:0000460)2.41850199
174translational termination (GO:0006415)2.41409445
175cytochrome complex assembly (GO:0017004)2.40500538
176indolalkylamine metabolic process (GO:0006586)2.39112389
177establishment of protein localization to mitochondrial membrane (GO:0090151)2.38862428
178detection of light stimulus involved in sensory perception (GO:0050962)2.38708600
179detection of light stimulus involved in visual perception (GO:0050908)2.38708600
180intracellular protein transmembrane import (GO:0044743)2.38154111
181nephron tubule morphogenesis (GO:0072078)2.38045134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.89959842
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.78095415
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.25724692
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.76110789
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.91131135
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.79472258
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.76759339
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.60771341
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49163981
10ZNF274_21170338_ChIP-Seq_K562_Hela3.21026322
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.03411063
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.00579442
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.96860073
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.25214681
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.22708773
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22321806
17* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.19174162
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12502318
19GATA1_22025678_ChIP-Seq_K562_Human2.10473816
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09642724
21E2F7_22180533_ChIP-Seq_HELA_Human2.06921387
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98399060
23* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93662582
24VDR_22108803_ChIP-Seq_LS180_Human1.91518083
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90135619
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89805504
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86006373
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85894969
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.75643988
30* SRF_21415370_ChIP-Seq_HL-1_Mouse1.72967956
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68562602
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.68334085
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.63721251
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63523680
35AR_21909140_ChIP-Seq_LNCAP_Human1.63037508
36MYC_18940864_ChIP-ChIP_HL60_Human1.62091350
37ERA_21632823_ChIP-Seq_H3396_Human1.60778222
38ZNF263_19887448_ChIP-Seq_K562_Human1.56241810
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55456492
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52763823
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52703463
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51980102
43TTF2_22483619_ChIP-Seq_HELA_Human1.46985475
44TP53_22573176_ChIP-Seq_HFKS_Human1.44898414
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.41739288
46CLOCK_20551151_ChIP-Seq_293T_Human1.41672080
47DCP1A_22483619_ChIP-Seq_HELA_Human1.40129117
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38528264
49IGF1R_20145208_ChIP-Seq_DFB_Human1.36820438
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36253565
51* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35334371
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33325076
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33115517
54* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32322852
55HOXB7_26014856_ChIP-Seq_BT474_Human1.25512744
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24204404
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22555289
58GABP_19822575_ChIP-Seq_HepG2_Human1.20941703
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.19416064
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.18526836
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18526836
62IRF1_19129219_ChIP-ChIP_H3396_Human1.16966733
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16756747
64* E2F1_20622854_ChIP-Seq_HELA_Human1.15932342
65FOXP3_21729870_ChIP-Seq_TREG_Human1.15615201
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13071216
67VDR_23849224_ChIP-Seq_CD4+_Human1.12937052
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12863696
69P53_21459846_ChIP-Seq_SAOS-2_Human1.12680915
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.12243710
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10670484
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10270888
73NCOR_22424771_ChIP-Seq_293T_Human1.10103249
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10102038
75* RAC3_21632823_ChIP-Seq_H3396_Human1.10056619
76* OCT4_20526341_ChIP-Seq_ESCs_Human1.08915008
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.08638998
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08323159
79EZH2_22144423_ChIP-Seq_EOC_Human1.08231440
80* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07516090
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07286612
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06260785
83XRN2_22483619_ChIP-Seq_HELA_Human1.06034722
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05625634
85AR_20517297_ChIP-Seq_VCAP_Human1.05002654
86ER_23166858_ChIP-Seq_MCF-7_Human1.04981292
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04708813
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03713550
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03193368
90KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02265778
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02217658
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01849672
93MYC_19829295_ChIP-Seq_ESCs_Human1.01729974
94ELK1_19687146_ChIP-ChIP_HELA_Human1.00935997
95P68_20966046_ChIP-Seq_HELA_Human1.00767137
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00147571
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99735633
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97918325
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97759229
100TAF2_19829295_ChIP-Seq_ESCs_Human0.97616845
101PHF8_20622854_ChIP-Seq_HELA_Human0.97547431
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97166585
103YY1_22570637_ChIP-Seq_MALME-3M_Human0.96732736
104CTCF_20526341_ChIP-Seq_ESCs_Human0.96575904
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96302527
106RNF2_27304074_Chip-Seq_NSC_Mouse0.95153276
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94994299
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94763497
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94375160
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92530814
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92268630
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92134101
113MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91841414
114RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91608570
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.91039091
116* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90674689
117THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90054785
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89547762
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89473715
120* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89454175
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88686533
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.88596337
123* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88208833
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86997255
125* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86940924
126HNF4A_19822575_ChIP-Seq_HepG2_Human0.86927665
127REST_21632747_ChIP-Seq_MESCs_Mouse0.86679253
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85949820
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.85311279
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83741657
131* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82348422
132KDM5A_27292631_Chip-Seq_BREAST_Human0.75930725
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75598908
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75378344
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75153211
136ATF3_27146783_Chip-Seq_COLON_Human0.75038761
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74917413
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74843899
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.74787455
140RARA_24833708_ChIP-Seq_LIVER_Mouse0.74037725
141* BCOR_27268052_Chip-Seq_Bcells_Human0.73992917
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72911841
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.72655876
144ERG_20517297_ChIP-Seq_VCAP_Human0.72452297
145* BCL6_27268052_Chip-Seq_Bcells_Human0.71161256
146CTCF_21964334_Chip-Seq_Bcells_Human0.70868798
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70519756
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70356240
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.70142781
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69727797
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69458250
152GATA4_25053715_ChIP-Seq_YYC3_Human0.68745124
153* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.68208032
154* YY1_21170310_ChIP-Seq_MESCs_Mouse0.67841494
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.67820439
156MYC_22102868_ChIP-Seq_BL_Human0.67492432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.30264910
2MP0005360_urolithiasis6.22620936
3MP0005085_abnormal_gallbladder_physiolo4.76849045
4MP0005365_abnormal_bile_salt4.76462568
5MP0003806_abnormal_nucleotide_metabolis4.55322340
6MP0008875_abnormal_xenobiotic_pharmacok3.77716052
7MP0005332_abnormal_amino_acid2.92684134
8MP0009840_abnormal_foam_cell2.85839814
9MP0010329_abnormal_lipoprotein_level2.79291221
10MP0003252_abnormal_bile_duct2.75865064
11MP0003646_muscle_fatigue2.73428606
12MP0006036_abnormal_mitochondrial_physio2.63696709
13MP0005083_abnormal_biliary_tract2.56692374
14MP0008877_abnormal_DNA_methylation2.46809710
15MP0002837_dystrophic_cardiac_calcinosis2.31625267
16MP0003195_calcinosis2.30404496
17MP0003656_abnormal_erythrocyte_physiolo2.22723985
18MP0003186_abnormal_redox_activity2.17531745
19MP0001666_abnormal_nutrient_absorption2.14263497
20MP0005551_abnormal_eye_electrophysiolog2.09849656
21MP0002160_abnormal_reproductive_system2.09061058
22MP0003191_abnormal_cellular_cholesterol2.02357775
23MP0005319_abnormal_enzyme/_coenzyme2.01110513
24MP0010030_abnormal_orbit_morphology1.99609923
25MP0009046_muscle_twitch1.98001030
26MP0004147_increased_porphyrin_level1.95557071
27MP0001764_abnormal_homeostasis1.92985041
28MP0000609_abnormal_liver_physiology1.89575679
29MP0003136_yellow_coat_color1.85638977
30MP0004019_abnormal_vitamin_homeostasis1.82099324
31MP0005670_abnormal_white_adipose1.82077724
32MP0002118_abnormal_lipid_homeostasis1.80244133
33MP0009643_abnormal_urine_homeostasis1.75622072
34MP0001968_abnormal_touch/_nociception1.74791924
35MP0004130_abnormal_muscle_cell1.74621387
36MP0008872_abnormal_physiological_respon1.73390557
37MP0005646_abnormal_pituitary_gland1.71082918
38MP0005584_abnormal_enzyme/coenzyme_acti1.70406976
39MP0002138_abnormal_hepatobiliary_system1.66931909
40MP0005389_reproductive_system_phenotype1.65183649
41MP0005451_abnormal_body_composition1.64933508
42MP0000749_muscle_degeneration1.63990215
43MP0002938_white_spotting1.63555684
44MP0006035_abnormal_mitochondrial_morpho1.60237157
45MP0002163_abnormal_gland_morphology1.60149361
46MP0002210_abnormal_sex_determination1.59545744
47MP0005636_abnormal_mineral_homeostasis1.56991671
48MP0005379_endocrine/exocrine_gland_phen1.56001882
49MP0008058_abnormal_DNA_repair1.51439052
50MP0002102_abnormal_ear_morphology1.51228582
51MP0001346_abnormal_lacrimal_gland1.47099201
52MP0006292_abnormal_olfactory_placode1.42671014
53MP0005330_cardiomyopathy1.41587483
54MP0004215_abnormal_myocardial_fiber1.39883857
55MP0001929_abnormal_gametogenesis1.36776743
56MP0003698_abnormal_male_reproductive1.36540577
57MP0002736_abnormal_nociception_after1.35250389
58MP0003880_abnormal_central_pattern1.35006456
59MP0000013_abnormal_adipose_tissue1.34759451
60MP0001919_abnormal_reproductive_system1.34345821
61MP0005645_abnormal_hypothalamus_physiol1.33169300
62MP0009745_abnormal_behavioral_response1.32472273
63MP0004043_abnormal_pH_regulation1.31078850
64MP0000427_abnormal_hair_cycle1.30305346
65MP0001529_abnormal_vocalization1.26479148
66MP0009379_abnormal_foot_pigmentation1.25934239
67MP0004084_abnormal_cardiac_muscle1.25051771
68MP0004036_abnormal_muscle_relaxation1.24870732
69MP0001145_abnormal_male_reproductive1.22944171
70MP0005666_abnormal_adipose_tissue1.22176476
71MP0002909_abnormal_adrenal_gland1.22078084
72MP0000751_myopathy1.21449985
73MP0001986_abnormal_taste_sensitivity1.21442166
74MP0002269_muscular_atrophy1.21376693
75MP0002272_abnormal_nervous_system1.20514661
76MP0000372_irregular_coat_pigmentation1.20008423
77MP0001905_abnormal_dopamine_level1.18907944
78MP0000653_abnormal_sex_gland1.16615582
79MP0002234_abnormal_pharynx_morphology1.16184389
80MP0000598_abnormal_liver_morphology1.15843670
81MP0003221_abnormal_cardiomyocyte_apopto1.15534395
82MP0003786_premature_aging1.14895623
83MP0004142_abnormal_muscle_tone1.14484915
84MP0005410_abnormal_fertilization1.12724107
85MP0005266_abnormal_metabolism1.11484344
86MP0002064_seizures1.10259555
87MP0010386_abnormal_urinary_bladder1.06501976
88MP0001756_abnormal_urination1.06281537
89MP0003879_abnormal_hair_cell1.05927935
90MP0009780_abnormal_chondrocyte_physiolo0.99503789
91MP0003959_abnormal_lean_body0.98890029
92MP0000747_muscle_weakness0.98396157
93MP0000003_abnormal_adipose_tissue0.97933201
94MP0000750_abnormal_muscle_regeneration0.97754178
95MP0002971_abnormal_brown_adipose0.97654017
96MP0004087_abnormal_muscle_fiber0.97207833
97MP0003718_maternal_effect0.96541352
98MP0002078_abnormal_glucose_homeostasis0.95659291
99MP0003868_abnormal_feces_composition0.94509206
100MP0000647_abnormal_sebaceous_gland0.93966407
101MP0008775_abnormal_heart_ventricle0.92948064
102MP0000631_abnormal_neuroendocrine_gland0.92070775
103MP0009697_abnormal_copulation0.91757202
104MP0004885_abnormal_endolymph0.89660094
105MP0003638_abnormal_response/metabolism_0.89550776
106MP0003705_abnormal_hypodermis_morpholog0.89341226
107MP0005220_abnormal_exocrine_pancreas0.88567058
108MP0008469_abnormal_protein_level0.88435609
109MP0005376_homeostasis/metabolism_phenot0.88179038
110MP0002572_abnormal_emotion/affect_behav0.87262942
111MP0005386_behavior/neurological_phenoty0.86859366
112MP0004924_abnormal_behavior0.86859366
113MP0005408_hypopigmentation0.86797080
114MP0009642_abnormal_blood_homeostasis0.85949044
115MP0009763_increased_sensitivity_to0.85889550
116MP0004742_abnormal_vestibular_system0.85844056
117MP0001485_abnormal_pinna_reflex0.84856656
118MP0002638_abnormal_pupillary_reflex0.84822432
119MP0005535_abnormal_body_temperature0.84728773
120MP0005423_abnormal_somatic_nervous0.84448334
121MP0005620_abnormal_muscle_contractility0.84281076
122MP0006072_abnormal_retinal_apoptosis0.83573656
123MP0010094_abnormal_chromosome_stability0.83424961
124MP0000566_synostosis0.82990689
125MP0002876_abnormal_thyroid_physiology0.82326237
126MP0002161_abnormal_fertility/fecundity0.82316251
127MP0001544_abnormal_cardiovascular_syste0.81873551
128MP0005385_cardiovascular_system_phenoty0.81873551
129MP0001502_abnormal_circadian_rhythm0.81719501
130MP0009764_decreased_sensitivity_to0.81633314
131MP0002557_abnormal_social/conspecific_i0.80556053
132MP0005084_abnormal_gallbladder_morpholo0.79617515
133MP0001853_heart_inflammation0.79311921
134MP0005253_abnormal_eye_physiology0.79267394
135MP0005334_abnormal_fat_pad0.78825722
136MP0006276_abnormal_autonomic_nervous0.78122802
137MP0004145_abnormal_muscle_electrophysio0.77835644
138MP0002735_abnormal_chemical_nociception0.77288886
139MP0000604_amyloidosis0.77082894
140MP0005647_abnormal_sex_gland0.76661212
141MP0002229_neurodegeneration0.76077546
142MP0003693_abnormal_embryo_hatching0.75527025
143MP0002136_abnormal_kidney_physiology0.73440698
144MP0002972_abnormal_cardiac_muscle0.72507368
145MP0002332_abnormal_exercise_endurance0.71878260
146MP0010630_abnormal_cardiac_muscle0.70811274
147MP0001765_abnormal_ion_homeostasis0.70580901
148MP0003011_delayed_dark_adaptation0.70348035
149MP0002106_abnormal_muscle_physiology0.66927970
150MP0001661_extended_life_span0.64340322
151MP0000230_abnormal_systemic_arterial0.63193493
152MP0004185_abnormal_adipocyte_glucose0.61961900
153MP0006138_congestive_heart_failure0.59780474
154MP0000358_abnormal_cell_content/0.59141452
155MP0005058_abnormal_lysosome_morphology0.55779761
156MP0002970_abnormal_white_adipose0.55067945
157MP0009672_abnormal_birth_weight0.54436627
158MP0003329_amyloid_beta_deposits0.53229327
159MP0000343_altered_response_to0.52899065
160MP0005395_other_phenotype0.50994531
161MP0005375_adipose_tissue_phenotype0.50035603
162MP0000759_abnormal_skeletal_muscle0.49412150
163MP0009115_abnormal_fat_cell0.46589739
164MP0009765_abnormal_xenobiotic_induced0.46574802
165MP0003953_abnormal_hormone_level0.46412096
166MP0005369_muscle_phenotype0.45641202
167MP0010368_abnormal_lymphatic_system0.44478551
168MP0002132_abnormal_respiratory_system0.44121059

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.81930405
2Hyperglycinuria (HP:0003108)4.80445249
3Intrahepatic cholestasis (HP:0001406)4.55154330
4Hyperammonemia (HP:0001987)4.40065385
5Abnormality of fatty-acid metabolism (HP:0004359)4.35152662
6Abnormality of glycine metabolism (HP:0010895)4.33850692
7Abnormality of serine family amino acid metabolism (HP:0010894)4.33850692
8Ketosis (HP:0001946)4.33659592
9Hyperglycinemia (HP:0002154)4.22032194
10Type II lissencephaly (HP:0007260)4.21782293
11Xanthomatosis (HP:0000991)4.16270582
12Deep venous thrombosis (HP:0002625)4.07220952
13Hypoglycemic coma (HP:0001325)4.05362092
14Ketoacidosis (HP:0001993)3.96949057
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96678796
16Gout (HP:0001997)3.81058314
17Hypobetalipoproteinemia (HP:0003563)3.78333310
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.72305047
19Dicarboxylic aciduria (HP:0003215)3.72238789
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.72238789
21Myoglobinuria (HP:0002913)3.67877198
22Hyperlipoproteinemia (HP:0010980)3.64321040
23Cerebellar dysplasia (HP:0007033)3.41317412
24Generalized aminoaciduria (HP:0002909)3.34788038
25Concave nail (HP:0001598)3.33244125
26Cerebral edema (HP:0002181)3.33145228
27Prolonged partial thromboplastin time (HP:0003645)3.31076924
28Hepatic necrosis (HP:0002605)3.29737740
29Hypolipoproteinemia (HP:0010981)3.28721776
30Rhabdomyolysis (HP:0003201)3.28084427
31Lethargy (HP:0001254)3.26205247
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23124400
33Abnormality of serum amino acid levels (HP:0003112)3.21341740
34Birth length less than 3rd percentile (HP:0003561)3.19551963
35Hypoalphalipoproteinemia (HP:0003233)3.18458958
36Metabolic acidosis (HP:0001942)3.18353630
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17974844
38Abnormal number of erythroid precursors (HP:0012131)3.12435255
39Abnormality of purine metabolism (HP:0004352)3.08296489
40Hyperbilirubinemia (HP:0002904)3.02298666
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.01440306
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95123100
43Congenital stationary night blindness (HP:0007642)2.95085990
44Acute encephalopathy (HP:0006846)2.92498194
45Abnormality of cells of the erythroid lineage (HP:0012130)2.90700555
46Nausea (HP:0002018)2.88123550
47Hypoplasia of the pons (HP:0012110)2.87266423
48Proximal tubulopathy (HP:0000114)2.86023577
49Pancreatic cysts (HP:0001737)2.86021113
50Hyperuricemia (HP:0002149)2.83851624
51Increased purine levels (HP:0004368)2.83851624
52Retinal atrophy (HP:0001105)2.83518541
53Abnormality of nucleobase metabolism (HP:0010932)2.82325065
54Increased muscle lipid content (HP:0009058)2.79246864
55Delayed CNS myelination (HP:0002188)2.78452449
56Abnormality of methionine metabolism (HP:0010901)2.76260128
57Complement deficiency (HP:0004431)2.73544428
58Molar tooth sign on MRI (HP:0002419)2.72132277
59Abnormality of midbrain morphology (HP:0002418)2.72132277
60Abnormality of the pons (HP:0007361)2.71002315
61Tubular atrophy (HP:0000092)2.70521783
62Abnormality of the renal cortex (HP:0011035)2.69978658
63Hepatocellular necrosis (HP:0001404)2.65751048
64Fat malabsorption (HP:0002630)2.65252110
65Abnormality of the intrinsic pathway (HP:0010989)2.62453130
66Vomiting (HP:0002013)2.62234204
67Pancreatic fibrosis (HP:0100732)2.61962517
68Exercise-induced myalgia (HP:0003738)2.57493209
69Lactic acidosis (HP:0003128)2.57034345
70Palpitations (HP:0001962)2.55573050
71Exercise-induced muscle cramps (HP:0003710)2.54851281
72Epidermoid cyst (HP:0200040)2.53612358
73Retinal dysplasia (HP:0007973)2.47305761
74Abnormal mitochondria in muscle tissue (HP:0008316)2.46662730
75Increased hepatocellular lipid droplets (HP:0006565)2.46232820
76Microretrognathia (HP:0000308)2.45799882
77Abnormality of the common coagulation pathway (HP:0010990)2.45480035
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45474483
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45474483
80Severe muscular hypotonia (HP:0006829)2.43399581
81Cholelithiasis (HP:0001081)2.42941298
82Opisthotonus (HP:0002179)2.42855561
83Abnormality of urine glucose concentration (HP:0011016)2.42404333
84Glycosuria (HP:0003076)2.42404333
85Nephronophthisis (HP:0000090)2.40190997
86Ragged-red muscle fibers (HP:0003200)2.39556532
87Lissencephaly (HP:0001339)2.36901481
88Pendular nystagmus (HP:0012043)2.35207990
89Abnormal gallbladder morphology (HP:0012437)2.34743582
90Increased CSF lactate (HP:0002490)2.34469931
91Increased serum pyruvate (HP:0003542)2.33980462
92Abnormality of glycolysis (HP:0004366)2.33980462
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.33229448
94Late onset (HP:0003584)2.33063171
95Increased intramyocellular lipid droplets (HP:0012240)2.32893637
96True hermaphroditism (HP:0010459)2.31364611
97Abnormality of pyrimidine metabolism (HP:0004353)2.30382219
98Abolished electroretinogram (ERG) (HP:0000550)2.29609373
99Hepatocellular carcinoma (HP:0001402)2.28762165
100Abnormality of alanine metabolism (HP:0010916)2.28446933
101Hyperalaninemia (HP:0003348)2.28446933
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28446933
103Acute necrotizing encephalopathy (HP:0006965)2.28380861
104Joint hemorrhage (HP:0005261)2.28037996
1053-Methylglutaconic aciduria (HP:0003535)2.26804350
106Multiple enchondromatosis (HP:0005701)2.26415810
107Cerebral hypomyelination (HP:0006808)2.24918507
108Renal cortical cysts (HP:0000803)2.24674758
109Large for gestational age (HP:0001520)2.24167017
110Decreased subcutaneous fat (HP:0001002)2.23135615
111Hypercholesterolemia (HP:0003124)2.21004328
112Polydipsia (HP:0001959)2.18225103
113Abnormal drinking behavior (HP:0030082)2.18225103
114Aplasia/Hypoplasia of the patella (HP:0006498)2.15949625
115Brushfield spots (HP:0001088)2.14042770
116Abnormal gallbladder physiology (HP:0012438)2.13709337
117Cholecystitis (HP:0001082)2.13709337
118Steatorrhea (HP:0002570)2.13100612
119Mitochondrial inheritance (HP:0001427)2.11142229
120Neoplasm of head and neck (HP:0012288)2.10689691
121Esophageal neoplasm (HP:0100751)2.10689691
122Patellar aplasia (HP:0006443)2.10094500
123Increased serum lactate (HP:0002151)2.09855587
124Bile duct proliferation (HP:0001408)2.09558191
125Abnormal biliary tract physiology (HP:0012439)2.09558191
126CNS demyelination (HP:0007305)2.08404739
127Attenuation of retinal blood vessels (HP:0007843)2.07483625
128Methylmalonic aciduria (HP:0012120)2.06851251
129Progressive macrocephaly (HP:0004481)2.06307487
130Neonatal onset (HP:0003623)2.05428710
131Abnormality of the renal medulla (HP:0100957)2.05046692
132Cystic liver disease (HP:0006706)2.03548321
133Brittle hair (HP:0002299)2.02964208
134Breast hypoplasia (HP:0003187)2.01902979
135Poikilocytosis (HP:0004447)2.01576585
136CNS hypomyelination (HP:0003429)2.00604614
137Inability to walk (HP:0002540)2.00326727
138Abnormality of DNA repair (HP:0003254)1.98262127
139Calf muscle hypertrophy (HP:0008981)1.97768931
140Progressive muscle weakness (HP:0003323)1.97478108
141Abnormal cartilage morphology (HP:0002763)1.96736474
142Malnutrition (HP:0004395)1.96551868
143Abnormality of transition element cation homeostasis (HP:0011030)1.95995466
144Spastic diplegia (HP:0001264)1.95023652
145Hypertriglyceridemia (HP:0002155)1.94050281
146Conjunctival hamartoma (HP:0100780)1.93780746
147Lipid accumulation in hepatocytes (HP:0006561)1.91874790
148Renal Fanconi syndrome (HP:0001994)1.90851933
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90544701
150Polyuria (HP:0000103)1.87611140
151Medial flaring of the eyebrow (HP:0010747)1.87187952
152Azoospermia (HP:0000027)1.83997415
153Congenital, generalized hypertrichosis (HP:0004540)1.79037461
154Confusion (HP:0001289)1.77918823
155Mesangial abnormality (HP:0001966)1.75681967
156Abnormality of subcutaneous fat tissue (HP:0001001)1.75315989
157Testicular atrophy (HP:0000029)1.73741673
158Female pseudohermaphroditism (HP:0010458)1.73256675
159Spontaneous abortion (HP:0005268)1.72908113
160Epiphyseal stippling (HP:0010655)1.72781927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.29231165
2NEK14.13400977
3PDK43.36516467
4PDK33.36516467
5TLK13.21133071
6MAP2K33.08001069
7ZAK2.99303403
8ADRBK22.95549031
9FRK2.93459563
10BMPR1B2.81947427
11EIF2AK12.72290350
12PKN22.65337556
13TRIB32.63251034
14GRK12.59831208
15OBSCN2.56803423
16NME22.36830347
17TTN2.05714356
18PINK11.95493696
19PDK21.94792667
20FLT31.94049218
21STK391.86873470
22ERN11.80742288
23STK161.70145364
24MAPKAPK31.69786009
25KDR1.62514943
26CDK191.58421960
27CDK81.56786779
28BUB11.50214392
29MAP3K31.47644531
30MAPK131.45593675
31MAP2K61.45467833
32STK38L1.44762756
33SIK11.42152615
34TESK21.37300527
35LIMK11.36892729
36DAPK21.36137560
37FGFR41.35183727
38VRK21.32324759
39MAP3K101.29476198
40MAP3K111.29382354
41PNCK1.28273514
42MAP4K21.24566672
43LMTK21.24562813
44PHKG21.20060675
45PHKG11.20060675
46EPHA21.19295293
47MAPK111.18689490
48OXSR11.17273147
49CDC71.16236359
50SRPK11.15981098
51ACVR1B1.14512743
52MAP2K21.14207732
53ABL21.13973152
54MYLK1.12981070
55MAPK121.12740683
56MAP2K41.11598663
57MET1.11027832
58NTRK31.10635213
59PIK3CG1.06168605
60VRK11.05480105
61NEK21.02683570
62SCYL21.02428451
63PRKCI1.02414700
64BRSK20.99964958
65EPHA40.96997322
66NEK90.86305823
67LRRK20.86037527
68CDK40.84975895
69WEE10.84710208
70PLK40.83467779
71EEF2K0.83154500
72INSRR0.81873380
73TAOK20.80903278
74ADRBK10.80475920
75TAOK30.79965462
76ERBB40.78734757
77TIE10.78586475
78TYK20.78540449
79PTK2B0.77715588
80CDK70.75952455
81RPS6KA50.74525789
82MUSK0.74519165
83CAMKK10.74014392
84PRKAA20.73077894
85WNK30.72853047
86SIK20.72362988
87EIF2AK30.71676450
88IRAK30.68707497
89JAK20.68500302
90PIK3CA0.67577014
91PRKAA10.64936126
92KSR20.63364536
93TBK10.62592632
94MAP3K50.61874866
95AURKA0.61525439
96MAP3K80.60669933
97MARK30.60264484
98TSSK60.59382397
99MAP3K70.58602713
100STK110.57543334
101DYRK30.57385935
102PBK0.56706491
103WNK40.55546505
104RPS6KA40.55125363
105MAP4K10.54233862
106CAMK10.53619855
107CHEK20.52472056
108RAF10.50718029
109AURKB0.49789218
110MST1R0.49720315
111MAPKAPK50.48187223
112ATR0.47068288
113STK240.46559518
114TTK0.45957188
115MAP2K10.45755029
116CAMKK20.45613598
117CSNK1G30.45228337
118CSNK1E0.44617564
119FGFR20.42144844
120CCNB10.41737842
121TGFBR10.41287675
122STK40.40805149
123ARAF0.40597319
124BRAF0.39409733
125CSNK1G20.38090037
126PRKCG0.37820746
127CAMK2A0.37496007
128PRKACA0.37348760
129CSNK2A20.36988385
130PRKCE0.36596610
131CSNK1G10.36527964
132CSNK1D0.36242119
133CSNK2A10.35871648
134CSNK1A10.35658795
135PAK30.35564391
136PRKACG0.35400361
137RPS6KB20.34736491
138PLK10.34497642
139BRSK10.33900270
140CAMK2D0.32531781
141CHEK10.32271910
142CSNK1A1L0.31608170
143LATS10.31487271
144PLK30.29922218
145CAMK2B0.29710420
146ZAP700.29692903
147PIM20.29561466
148JAK30.29209581
149NME10.28888497
150GRK60.28806048
151PDK10.28717569
152TAOK10.28334218
153CAMK2G0.28111922
154AKT20.27666374
155PDPK10.27414668
156SGK20.26682755
157MAPK40.25806489
158STK100.24981008

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.21896742
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06561799
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05817302
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02811075
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98102452
6Fatty acid degradation_Homo sapiens_hsa000712.94543432
7Propanoate metabolism_Homo sapiens_hsa006402.92095733
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.88666714
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61958812
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33991617
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30381069
12Arginine biosynthesis_Homo sapiens_hsa002202.23349156
13Tryptophan metabolism_Homo sapiens_hsa003802.19151659
14Butanoate metabolism_Homo sapiens_hsa006502.15840607
15Pyruvate metabolism_Homo sapiens_hsa006202.14472594
16Carbon metabolism_Homo sapiens_hsa012002.14459086
17Peroxisome_Homo sapiens_hsa041462.11931303
18Nitrogen metabolism_Homo sapiens_hsa009102.11556508
19Fatty acid metabolism_Homo sapiens_hsa012122.06693623
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99180570
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89375018
22beta-Alanine metabolism_Homo sapiens_hsa004101.89188191
23Biosynthesis of amino acids_Homo sapiens_hsa012301.77713446
24PPAR signaling pathway_Homo sapiens_hsa033201.70666489
25Selenocompound metabolism_Homo sapiens_hsa004501.65288372
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65273737
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.65022907
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.62240435
29Folate biosynthesis_Homo sapiens_hsa007901.61085083
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56844725
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53225892
32Phototransduction_Homo sapiens_hsa047441.52138570
33Complement and coagulation cascades_Homo sapiens_hsa046101.49407912
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40897441
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37439742
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.37362538
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36837667
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35977397
39Vitamin B6 metabolism_Homo sapiens_hsa007501.29729912
40Caffeine metabolism_Homo sapiens_hsa002321.29082665
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27045379
42Basal transcription factors_Homo sapiens_hsa030221.26514073
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26234478
44Chemical carcinogenesis_Homo sapiens_hsa052041.26080655
45Starch and sucrose metabolism_Homo sapiens_hsa005001.23474696
46Histidine metabolism_Homo sapiens_hsa003401.23217400
47Phenylalanine metabolism_Homo sapiens_hsa003601.22212003
48One carbon pool by folate_Homo sapiens_hsa006701.20749187
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18255541
50Pentose phosphate pathway_Homo sapiens_hsa000301.18194335
51Fatty acid elongation_Homo sapiens_hsa000621.13805104
52Arginine and proline metabolism_Homo sapiens_hsa003301.13170860
53Fanconi anemia pathway_Homo sapiens_hsa034601.08752937
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08431943
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.03915366
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03540072
57Retinol metabolism_Homo sapiens_hsa008301.02830528
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01265415
59Sulfur metabolism_Homo sapiens_hsa009200.99493347
60Tyrosine metabolism_Homo sapiens_hsa003500.99477302
61Bile secretion_Homo sapiens_hsa049760.99096282
62Glutathione metabolism_Homo sapiens_hsa004800.98179556
63Nicotine addiction_Homo sapiens_hsa050330.97492472
64Fat digestion and absorption_Homo sapiens_hsa049750.95823793
65Protein export_Homo sapiens_hsa030600.95309419
66* Sulfur relay system_Homo sapiens_hsa041220.93388326
67Parkinsons disease_Homo sapiens_hsa050120.93112088
68RNA degradation_Homo sapiens_hsa030180.92737095
69Oxidative phosphorylation_Homo sapiens_hsa001900.92234505
70Vitamin digestion and absorption_Homo sapiens_hsa049770.87500815
71Proteasome_Homo sapiens_hsa030500.85654029
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84550787
73ABC transporters_Homo sapiens_hsa020100.80077458
74Glycerolipid metabolism_Homo sapiens_hsa005610.79697911
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76476310
76Fructose and mannose metabolism_Homo sapiens_hsa000510.75491707
77RNA transport_Homo sapiens_hsa030130.74444677
78* Metabolic pathways_Homo sapiens_hsa011000.74128949
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73001093
80Staphylococcus aureus infection_Homo sapiens_hsa051500.66258052
81Lysine degradation_Homo sapiens_hsa003100.66090839
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65902474
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.65496798
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65343242
85DNA replication_Homo sapiens_hsa030300.65082547
86Ether lipid metabolism_Homo sapiens_hsa005650.64865365
87Pyrimidine metabolism_Homo sapiens_hsa002400.60733953
88Galactose metabolism_Homo sapiens_hsa000520.60353296
89Arachidonic acid metabolism_Homo sapiens_hsa005900.59202047
90Fatty acid biosynthesis_Homo sapiens_hsa000610.56257557
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50495270
92Huntingtons disease_Homo sapiens_hsa050160.49395989
93Insulin secretion_Homo sapiens_hsa049110.48972633
94Alzheimers disease_Homo sapiens_hsa050100.47179734
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46682583
96Ovarian steroidogenesis_Homo sapiens_hsa049130.43484017
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.40927699
98Cardiac muscle contraction_Homo sapiens_hsa042600.38667646
99Mismatch repair_Homo sapiens_hsa034300.34440756
100Ribosome_Homo sapiens_hsa030100.30716597
101Insulin resistance_Homo sapiens_hsa049310.29307188
102Steroid biosynthesis_Homo sapiens_hsa001000.29161194
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23761541
104Glucagon signaling pathway_Homo sapiens_hsa049220.23376783
105Purine metabolism_Homo sapiens_hsa002300.20662794
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20357507
107RNA polymerase_Homo sapiens_hsa030200.19989157
108AMPK signaling pathway_Homo sapiens_hsa041520.17406783
109Nucleotide excision repair_Homo sapiens_hsa034200.16402482
110Base excision repair_Homo sapiens_hsa034100.15449662
111Renin-angiotensin system_Homo sapiens_hsa046140.15252046
112Linoleic acid metabolism_Homo sapiens_hsa005910.14737112
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.13715875
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13115997
115Regulation of autophagy_Homo sapiens_hsa041400.12247812
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10172922
117Insulin signaling pathway_Homo sapiens_hsa049100.07796942
118Homologous recombination_Homo sapiens_hsa034400.02589676
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0035442

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