NFKBIZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muramyl dipeptide (GO:0032495)5.35755379
2positive regulation by symbiont of host defense response (GO:0052509)4.66796015
3modulation by symbiont of host defense response (GO:0052031)4.66796015
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66796015
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66796015
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.66796015
7modulation by symbiont of host immune response (GO:0052553)4.66796015
8response to peptidoglycan (GO:0032494)4.35565859
9neutrophil activation involved in immune response (GO:0002283)4.20943590
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07479683
11positive regulation of heat generation (GO:0031652)4.04117309
12regulation of chronic inflammatory response (GO:0002676)4.03142068
13regulation of interleukin-12 biosynthetic process (GO:0045075)4.01663657
14NIK/NF-kappaB signaling (GO:0038061)4.00570877
15positive regulation of gamma-delta T cell activation (GO:0046645)3.94811115
16cellular extravasation (GO:0045123)3.89831779
17regulation of fever generation (GO:0031620)3.80738400
18macrophage activation involved in immune response (GO:0002281)3.76418990
19microglial cell activation (GO:0001774)3.72364812
20positive regulation of chemokine biosynthetic process (GO:0045080)3.65337728
21tolerance induction (GO:0002507)3.64903165
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61826335
23positive regulation of cellular amide metabolic process (GO:0034250)3.44823216
24regulation of interferon-alpha production (GO:0032647)3.40492096
25negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.38244623
26detection of molecule of bacterial origin (GO:0032490)3.36089867
27germinal center formation (GO:0002467)3.36023264
28antigen processing and presentation of endogenous antigen (GO:0019883)3.35679885
29detection of other organism (GO:0098543)3.35342796
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33373565
31leukocyte aggregation (GO:0070486)3.31365432
32positive regulation of interferon-alpha production (GO:0032727)3.29268413
33negative regulation of interleukin-12 production (GO:0032695)3.26867637
34positive regulation of interleukin-12 production (GO:0032735)3.25244217
35negative regulation of lipid storage (GO:0010888)3.23747866
36granulocyte activation (GO:0036230)3.22332436
37regulation of gamma-delta T cell differentiation (GO:0045586)3.18294043
38neutrophil activation (GO:0042119)3.17978271
39modulation by symbiont of host cellular process (GO:0044068)3.15383469
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15365601
41cytokine secretion (GO:0050663)3.14500735
42regulation of heat generation (GO:0031650)3.14473128
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13296681
44immunoglobulin mediated immune response (GO:0016064)3.12454532
45negative regulation of interleukin-1 beta production (GO:0032691)3.09846797
46myeloid dendritic cell differentiation (GO:0043011)3.09105868
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.07166030
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07086728
49macrophage activation (GO:0042116)3.06769265
50detection of bacterium (GO:0016045)3.05990952
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05662147
52response to host immune response (GO:0052572)3.05321978
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05321978
54regulation of interferon-beta biosynthetic process (GO:0045357)3.04828494
55myeloid dendritic cell activation (GO:0001773)3.03278194
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03178916
57regulation of chemokine biosynthetic process (GO:0045073)3.02903393
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02677478
59regulation of B cell receptor signaling pathway (GO:0050855)3.02332624
60regulation of T-helper 1 cell differentiation (GO:0045625)3.00274145
61detection of external biotic stimulus (GO:0098581)2.97401418
62regulation of T-helper 2 cell differentiation (GO:0045628)2.95417121
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95183296
64detection of biotic stimulus (GO:0009595)2.95105173
65positive regulation of interleukin-1 beta secretion (GO:0050718)2.93286063
66T-helper 1 type immune response (GO:0042088)2.93284924
67interferon-gamma-mediated signaling pathway (GO:0060333)2.93272291
68negative regulation of erythrocyte differentiation (GO:0045647)2.92691762
69regulation of interleukin-12 production (GO:0032655)2.92420069
70myeloid cell activation involved in immune response (GO:0002275)2.91534739
71regulation of gamma-delta T cell activation (GO:0046643)2.91529369
72response to host (GO:0075136)2.90977187
73response to host defenses (GO:0052200)2.90977187
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90977187
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90223247
76positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89770592
77negative regulation of interleukin-1 production (GO:0032692)2.89624616
78positive regulation of antigen processing and presentation (GO:0002579)2.87699946
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87011065
80regulation of vitamin D biosynthetic process (GO:0060556)2.85630534
81positive regulation of humoral immune response (GO:0002922)2.83735360
82neutrophil mediated immunity (GO:0002446)2.83093599
83negative regulation of T cell mediated immunity (GO:0002710)2.81833543
84leukocyte cell-cell adhesion (GO:0007159)2.79640612
85G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77592503
86B cell homeostasis (GO:0001782)2.77405882
87natural killer cell mediated immunity (GO:0002228)2.77201621
88natural killer cell mediated cytotoxicity (GO:0042267)2.77201621
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76909494
90cell adhesion mediated by integrin (GO:0033627)2.76094716
91defense response to protozoan (GO:0042832)2.76093148
92I-kappaB phosphorylation (GO:0007252)2.75347758
93negative regulation of cell killing (GO:0031342)2.74710953
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74710953
95negative regulation of cytokine production involved in immune response (GO:0002719)2.74648737
96regulation of germinal center formation (GO:0002634)2.74585329
97positive regulation of type 2 immune response (GO:0002830)2.74498355
98regulation of interleukin-6 biosynthetic process (GO:0045408)2.73790520
99T-helper cell differentiation (GO:0042093)2.73354581
100CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.73354581
101positive regulation of interleukin-1 secretion (GO:0050716)2.72752970
102positive regulation of interferon-beta production (GO:0032728)2.72627778
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70984825
104response to protozoan (GO:0001562)2.70973353
105negative regulation of interleukin-8 production (GO:0032717)2.70170734
106negative regulation of interleukin-6 production (GO:0032715)2.70034931
107negative regulation of T-helper cell differentiation (GO:0045623)2.69905268
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69905268
109regulation of vitamin metabolic process (GO:0030656)2.68097055
110monocyte chemotaxis (GO:0002548)2.68039656
111positive regulation of interleukin-2 production (GO:0032743)2.67991824
112regulation of interleukin-1 beta secretion (GO:0050706)2.67215114
113respiratory burst (GO:0045730)2.66396437
114nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.66368337
115positive regulation of B cell differentiation (GO:0045579)2.66174025
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65631940
117regulation of mast cell degranulation (GO:0043304)2.64243757
118positive regulation of p38MAPK cascade (GO:1900745)2.63960308
119T cell activation involved in immune response (GO:0002286)2.63731208
120positive regulation of interleukin-1 beta production (GO:0032731)2.63130869
121myeloid leukocyte mediated immunity (GO:0002444)2.62291283
122positive thymic T cell selection (GO:0045059)2.62190444
123negative regulation of lymphocyte mediated immunity (GO:0002707)2.61903260
124regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.61793356
125positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61325206
126negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61196400
127regulation of interleukin-8 biosynthetic process (GO:0045414)2.60961537
128regulation of alpha-beta T cell proliferation (GO:0046640)2.60890782
129response to type I interferon (GO:0034340)2.60781466
130type I interferon signaling pathway (GO:0060337)2.60755405
131cellular response to type I interferon (GO:0071357)2.60755405
132regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60730876
133regulation of interleukin-6 production (GO:0032675)2.60659325
134regulation of tolerance induction (GO:0002643)2.60539061
135regulation of podosome assembly (GO:0071801)2.60307025
136negative thymic T cell selection (GO:0045060)2.60169679
137regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.59650102
138positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.58545610
139B cell mediated immunity (GO:0019724)2.57083229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.43861628
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.93764683
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.68777865
4* IRF8_22096565_ChIP-ChIP_GC-B_Human4.66982178
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14492765
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.74744319
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.65515563
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.54887212
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.53656847
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34954993
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28909341
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20274638
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19132520
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12550725
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96952368
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79426920
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72202911
18* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58887797
19RUNX_20019798_ChIP-Seq_JUKART_Human2.42547850
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33704380
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28111248
22SCL_19346495_ChIP-Seq_HPC-7_Human2.27166468
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.11378043
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02990198
25VDR_24787735_ChIP-Seq_THP-1_Human1.95983477
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94062721
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91305116
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.81659378
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80624880
30MYB_26560356_Chip-Seq_TH2_Human1.79172834
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73838337
32* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72699582
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71050735
34VDR_24763502_ChIP-Seq_THP-1_Human1.68452071
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.65653212
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64644758
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63471789
38PU_27001747_Chip-Seq_BMDM_Mouse1.61086952
39MAF_26560356_Chip-Seq_TH1_Human1.52871993
40SPI1_23547873_ChIP-Seq_NB4_Human1.52860295
41SPI1_23127762_ChIP-Seq_K562_Human1.50442186
42* MYB_26560356_Chip-Seq_TH1_Human1.46630649
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37593054
44* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35015048
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.32677145
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28740441
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.27998186
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27434093
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27434093
50* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26020794
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24809595
52GATA1_22025678_ChIP-Seq_K562_Human1.24459582
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23450332
54* TCF7_22412390_ChIP-Seq_EML_Mouse1.22909460
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.18845848
56MYC_22102868_ChIP-Seq_BL_Human1.18631077
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18522264
58GATA3_27048872_Chip-Seq_THYMUS_Human1.16962167
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.14960725
60CJUN_26792858_Chip-Seq_BT549_Human1.14728850
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14131008
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14079934
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13688443
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12321948
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10710099
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10215298
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09981171
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07950305
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07615972
70VDR_21846776_ChIP-Seq_THP-1_Human1.06990298
71* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06848515
72* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05865073
73* GATA3_26560356_Chip-Seq_TH2_Human1.03840588
74UTX_26944678_Chip-Seq_JUKART_Human1.03093085
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.02400846
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02269027
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01094368
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99510622
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98415351
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97848655
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97721539
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.97267593
83* KDM2B_26808549_Chip-Seq_DND41_Human0.96703318
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95818642
85MAF_26560356_Chip-Seq_TH2_Human0.94636423
86GATA2_19941826_ChIP-Seq_K562_Human0.94633451
87* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93818434
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93352925
89* SOX2_20726797_ChIP-Seq_SW620_Human0.92602210
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.92266125
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91475346
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91455073
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90253589
94* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90121730
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.87676976
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87645605
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87110748
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86997960
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85410158
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83973838
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83758622
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.82632740
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81992362
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81944734
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81944734
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81944734
107SMRT_27268052_Chip-Seq_Bcells_Human0.81820404
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81490724
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80426697
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79993921
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79993921
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79023727
113GATA1_19941826_ChIP-Seq_K562_Human0.78934567
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78656091
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77470340
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.76963342
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76586431
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76536237
119* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75410337
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75402022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.80161984
2MP0009785_altered_susceptibility_to3.42474149
3MP0003436_decreased_susceptibility_to3.39051410
4MP0003303_peritoneal_inflammation3.34606392
5MP0003724_increased_susceptibility_to3.31104550
6MP0005000_abnormal_immune_tolerance3.09101959
7MP0002148_abnormal_hypersensitivity_rea3.08213065
8MP0002419_abnormal_innate_immunity2.88282404
9MP0005671_abnormal_response_to2.80438213
10MP0001790_abnormal_immune_system2.73836656
11MP0005387_immune_system_phenotype2.73836656
12MP0000685_abnormal_immune_system2.65668248
13MP0006082_CNS_inflammation2.64597114
14* MP0001800_abnormal_humoral_immune2.61115213
15MP0005025_abnormal_response_to2.59528114
16* MP0002452_abnormal_antigen_presenting2.56390649
17MP0000569_abnormal_digit_pigmentation2.52602378
18MP0009278_abnormal_bone_marrow2.51256164
19* MP0002723_abnormal_immune_serum2.50254550
20MP0004510_myositis2.45178664
21* MP0004947_skin_inflammation2.30252533
22* MP0001819_abnormal_immune_cell2.17804387
23* MP0002420_abnormal_adaptive_immunity2.16558941
24MP0002405_respiratory_system_inflammati2.11323999
25MP0001853_heart_inflammation2.11279287
26MP0003300_gastrointestinal_ulcer2.10246973
27MP0002254_reproductive_system_inflammat2.02942532
28MP0001533_abnormal_skeleton_physiology1.99435659
29MP0005464_abnormal_platelet_physiology1.94986164
30MP0010155_abnormal_intestine_physiology1.93133652
31MP0008004_abnormal_stomach_pH1.86503928
32MP0002006_tumorigenesis1.86290998
33MP0001845_abnormal_inflammatory_respons1.81894550
34MP0003448_altered_tumor_morphology1.75327573
35MP0005397_hematopoietic_system_phenotyp1.72658229
36MP0001545_abnormal_hematopoietic_system1.72658229
37MP0003763_abnormal_thymus_physiology1.66122027
38MP0009764_decreased_sensitivity_to1.65050755
39MP0002166_altered_tumor_susceptibility1.62602745
40MP0005058_abnormal_lysosome_morphology1.61358895
41MP0001873_stomach_inflammation1.58839006
42MP0000716_abnormal_immune_system1.54409069
43MP0002933_joint_inflammation1.53191188
44MP0003453_abnormal_keratinocyte_physiol1.52212771
45MP0002998_abnormal_bone_remodeling1.49194818
46MP0002398_abnormal_bone_marrow1.48826359
47MP0003828_pulmonary_edema1.44506415
48MP0005076_abnormal_cell_differentiation1.44201675
49MP0003656_abnormal_erythrocyte_physiolo1.43787634
50MP0008469_abnormal_protein_level1.42327115
51MP0009333_abnormal_splenocyte_physiolog1.41213506
52MP0000858_altered_metastatic_potential1.38888079
53MP0002138_abnormal_hepatobiliary_system1.37611204
54MP0005167_abnormal_blood-brain_barrier1.36932998
55MP0000343_altered_response_to1.36492450
56MP0003075_altered_response_to1.33163825
57MP0005310_abnormal_salivary_gland1.30864110
58MP0002277_abnormal_respiratory_mucosa1.30199769
59MP0003172_abnormal_lysosome_physiology1.27273237
60MP0003183_abnormal_peptide_metabolism1.25418282
61MP0000689_abnormal_spleen_morphology1.23305383
62MP0002429_abnormal_blood_cell1.19067952
63MP0002722_abnormal_immune_system1.15973374
64* MP0001851_eye_inflammation1.14566819
65MP0003566_abnormal_cell_adhesion1.14524133
66MP0005390_skeleton_phenotype1.13626251
67MP0003191_abnormal_cellular_cholesterol1.13438549
68MP0002332_abnormal_exercise_endurance1.11891095
69MP0010352_gastrointestinal_tract_polyps1.11287422
70MP0005174_abnormal_tail_pigmentation1.06405080
71MP0005164_abnormal_response_to1.04939466
72MP0008260_abnormal_autophagy1.03021042
73MP0005166_decreased_susceptibility_to1.02886244
74MP0002132_abnormal_respiratory_system1.01568423
75MP0003091_abnormal_cell_migration1.01404582
76MP0000249_abnormal_blood_vessel0.99544012
77MP0001501_abnormal_sleep_pattern0.99420972
78MP0000465_gastrointestinal_hemorrhage0.99341369
79MP0003195_calcinosis0.98690900
80MP0005023_abnormal_wound_healing0.98632350
81MP0009763_increased_sensitivity_to0.94020341
82MP0004381_abnormal_hair_follicle0.90513676
83MP0002139_abnormal_hepatobiliary_system0.89218146
84MP0004808_abnormal_hematopoietic_stem0.89053667
85MP0009840_abnormal_foam_cell0.88965359
86MP0002877_abnormal_melanocyte_morpholog0.88188869
87MP0003866_abnormal_defecation0.86326781
88MP0000703_abnormal_thymus_morphology0.85176174
89MP0009765_abnormal_xenobiotic_induced0.85063280
90MP0006054_spinal_hemorrhage0.82647391
91MP0001243_abnormal_dermal_layer0.79418846
92MP0004883_abnormal_blood_vessel0.79407298
93MP0003795_abnormal_bone_structure0.78942789
94MP0003045_fibrosis0.78788993
95MP0001663_abnormal_digestive_system0.78089445
96MP0000767_abnormal_smooth_muscle0.76966841
97MP0004484_altered_response_of0.75818998
98MP0004782_abnormal_surfactant_physiolog0.75643912
99MP0000383_abnormal_hair_follicle0.74791932
100MP0000604_amyloidosis0.74787312
101MP0000371_diluted_coat_color0.74766780
102MP0002009_preneoplasia0.72568858
103MP0005451_abnormal_body_composition0.72540135
104MP0000015_abnormal_ear_pigmentation0.71533763
105MP0001879_abnormal_lymphatic_vessel0.71390531
106MP0001958_emphysema0.70649608
107MP0005165_increased_susceptibility_to0.70020305
108MP0005257_abnormal_intraocular_pressure0.68523838
109* MP0001216_abnormal_epidermal_layer0.68409119
110MP0001542_abnormal_bone_strength0.68102197
111* MP0001191_abnormal_skin_condition0.67445669
112MP0003690_abnormal_glial_cell0.67420526
113MP0002396_abnormal_hematopoietic_system0.66404379
114MP0010307_abnormal_tumor_latency0.66311745
115MP0003950_abnormal_plasma_membrane0.66025267
116MP0003252_abnormal_bile_duct0.65634626
117MP0002136_abnormal_kidney_physiology0.61803396
118MP0005535_abnormal_body_temperature0.60532247

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.99180494
2Stomatitis (HP:0010280)5.73404101
3Recurrent bacterial skin infections (HP:0005406)5.69978246
4Elevated erythrocyte sedimentation rate (HP:0003565)5.67136125
5Eczematoid dermatitis (HP:0000976)5.63863425
6Retrobulbar optic neuritis (HP:0100654)5.39110303
7Optic neuritis (HP:0100653)5.39110303
8Orchitis (HP:0100796)5.27859397
9Myositis (HP:0100614)4.98835697
10Mediastinal lymphadenopathy (HP:0100721)4.42493945
11Recurrent gram-negative bacterial infections (HP:0005420)3.93977298
12Vasculitis (HP:0002633)3.89715809
13Thick nail (HP:0001805)3.82344740
14Prostate neoplasm (HP:0100787)3.75003187
15Abnormality of macrophages (HP:0004311)3.73467114
16Pulmonary infiltrates (HP:0002113)3.70619845
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.56505567
18Hematochezia (HP:0002573)3.52215347
19Gingivitis (HP:0000230)3.51951226
20Recurrent skin infections (HP:0001581)3.48258131
21Recurrent fungal infections (HP:0002841)3.46046048
22Keratoconjunctivitis sicca (HP:0001097)3.34136378
23Pustule (HP:0200039)3.32712387
24Arterial thrombosis (HP:0004420)3.17684146
25Periodontitis (HP:0000704)3.15876107
26Autoimmune hemolytic anemia (HP:0001890)3.14268982
27Autoimmune thrombocytopenia (HP:0001973)3.08601519
28Systemic lupus erythematosus (HP:0002725)3.07496213
29Leukocytosis (HP:0001974)3.06769398
30Keratoconjunctivitis (HP:0001096)3.05413084
31Increased IgE level (HP:0003212)3.03785460
32Obstructive lung disease (HP:0006536)3.00000734
33Chronic obstructive pulmonary disease (HP:0006510)3.00000734
34Hemoptysis (HP:0002105)2.90504674
35Recurrent viral infections (HP:0004429)2.76386250
36Amyloidosis (HP:0011034)2.74587537
37Vacuolated lymphocytes (HP:0001922)2.73786431
38Alveolar cell carcinoma (HP:0006519)2.71108780
39Abnormality of the prostate (HP:0008775)2.67222925
40Neoplasm of the tracheobronchial system (HP:0100552)2.64129824
41Myocardial infarction (HP:0001658)2.61427216
42Gastrointestinal infarctions (HP:0005244)2.58059513
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.57937310
44Meningitis (HP:0001287)2.56593506
45Premature loss of primary teeth (HP:0006323)2.55960701
46Increased cerebral lipofuscin (HP:0011813)2.55797065
47Recurrent cutaneous fungal infections (HP:0011370)2.51593007
48Chronic mucocutaneous candidiasis (HP:0002728)2.51593007
49Increased IgM level (HP:0003496)2.51299660
50Glomerulonephritis (HP:0000099)2.50879639
51Osteomyelitis (HP:0002754)2.46334021
52Cellulitis (HP:0100658)2.42914949
53Abnormality of T cells (HP:0002843)2.42164337
54Gingival bleeding (HP:0000225)2.41714344
55Interstitial pulmonary disease (HP:0006530)2.39577712
56Joint swelling (HP:0001386)2.39510954
57Spontaneous hematomas (HP:0007420)2.39372831
58Gangrene (HP:0100758)2.38474384
59Colitis (HP:0002583)2.37498237
60Recurrent bronchitis (HP:0002837)2.35909747
61Dysostosis multiplex (HP:0000943)2.34236836
62Eosinophilia (HP:0001880)2.33361836
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.32369623
64Osteolytic defects of the hand bones (HP:0009699)2.32369623
65Urticaria (HP:0001025)2.31360348
66Spondylolisthesis (HP:0003302)2.30906675
67Abnormality of T cell physiology (HP:0011840)2.30795867
68Anhidrosis (HP:0000970)2.25529829
69Stomach cancer (HP:0012126)2.24293303
70Chronic diarrhea (HP:0002028)2.23944755
71Agammaglobulinemia (HP:0004432)2.23693742
72Abnormality of the pericardium (HP:0001697)2.22070112
73Inflammation of the large intestine (HP:0002037)2.18430443
74Abnormality of the nasal septum (HP:0000419)2.17919852
75Tetraparesis (HP:0002273)2.16758455
76Submucous cleft hard palate (HP:0000176)2.16492521
77Abnormality of T cell number (HP:0011839)2.16266856
78Panhypogammaglobulinemia (HP:0003139)2.16255326
79Persistence of primary teeth (HP:0006335)2.13145214
80Anorexia (HP:0002039)2.12339148
81Recurrent pneumonia (HP:0006532)2.12111169
82Pulmonary embolism (HP:0002204)2.11300039
83Abnormality of liposaccharide metabolism (HP:0010968)2.11128600
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.11128600
85Abnormality of glycolipid metabolism (HP:0010969)2.11128600
86Epistaxis (HP:0000421)2.09994112
87Axonal loss (HP:0003447)2.09808584
88Viral hepatitis (HP:0006562)2.09401258
89Petechiae (HP:0000967)2.09083503
90Malnutrition (HP:0004395)2.08970040
91Abnormality of eosinophils (HP:0001879)2.05231740
92T lymphocytopenia (HP:0005403)2.04281764
93Fatigue (HP:0012378)2.03521653
94Loss of speech (HP:0002371)2.03383452
95Bone pain (HP:0002653)2.02840327
96Abnormality of the pleura (HP:0002103)2.01411046
97Arthralgia (HP:0002829)2.01142966
98Restrictive lung disease (HP:0002091)2.01124724
99Basal ganglia calcification (HP:0002135)2.00499512
100Abnormality of polysaccharide metabolism (HP:0011012)2.00380614
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00380614
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00380614
103Urinary glycosaminoglycan excretion (HP:0003541)1.99206612
104Mucopolysacchariduria (HP:0008155)1.99206612
105Slow saccadic eye movements (HP:0000514)1.98904025
106Pulmonary artery stenosis (HP:0004415)1.98867146
107Thyroiditis (HP:0100646)1.97719486
108Polyneuropathy (HP:0001271)1.97153737
109Increased CSF protein (HP:0002922)1.97037171
110Gastrointestinal inflammation (HP:0004386)1.96880712
111Increased serum ferritin (HP:0003281)1.96032845
112Glomerulopathy (HP:0100820)1.94702142
113Urethral obstruction (HP:0000796)1.90870043
114Episodic fever (HP:0001954)1.89078722
115Chest pain (HP:0100749)1.87200549
116Vertebral compression fractures (HP:0002953)1.86609103
117Hypergammaglobulinemia (HP:0010702)1.85565720
118Granulocytopenia (HP:0001913)1.85359378
119Gastrointestinal stroma tumor (HP:0100723)1.85332105
120Skin ulcer (HP:0200042)1.83733762
121Keratitis (HP:0000491)1.83085791
122Abnormality of the fingertips (HP:0001211)1.79676830
123Prolonged bleeding time (HP:0003010)1.78102950
124Encephalitis (HP:0002383)1.77809684
125Nephritis (HP:0000123)1.77709801
126IgA deficiency (HP:0002720)1.74393590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.37202222
2TXK4.03485474
3IRAK33.88767671
4TBK13.29026648
5IKBKE2.94771463
6IKBKB2.85788793
7IRAK42.77399221
8RIPK42.74454216
9TYK22.73435680
10MAP4K12.47369134
11JAK32.25451886
12BLK2.24046319
13TGFBR22.22440090
14CHUK2.15935761
15JAK12.03257415
16PRPF4B2.00207791
17TAOK31.90538760
18MAP3K131.67671838
19STK101.59535838
20MAPK151.54858662
21BMPR21.53285496
22ZAP701.52541256
23EPHB11.50393654
24ITK1.47514394
25TEC1.39438439
26KIT1.38965912
27CSK1.37486670
28GRK61.37455249
29ERN11.34322026
30NEK91.28882307
31MAP3K31.26266571
32HCK1.21979369
33MST41.19686620
34PIM21.14689858
35JAK21.12698217
36RPS6KA41.12291680
37PIM11.12057334
38LCK1.11327296
39EIF2AK21.10118563
40RIPK11.09451931
41BTK1.09271920
42PDK21.02151692
43EPHA31.01902274
44MAP3K100.99870037
45MARK30.98722964
46AKT30.97751388
47FGFR30.96166784
48SYK0.95740702
49PIK3CG0.91271522
50PTK60.89801393
51CDC42BPA0.88797630
52GRK70.87965996
53CSF1R0.86738227
54TAOK20.86110672
55IRAK10.85388822
56SIK30.85230470
57TRPM70.83541133
58TNK20.82875578
59LYN0.79015363
60MAP2K30.78674732
61CDK120.78305226
62FGFR40.75978470
63TAOK10.74295126
64MAP3K60.72097812
65NLK0.70799465
66PDK10.70344413
67FGR0.69687204
68PDGFRB0.64270533
69MAP3K110.63575102
70MST1R0.61451809
71MAP3K20.61249930
72SIK20.60634491
73MAPKAPK20.60118976
74FES0.60063427
75NUAK10.58088714
76MOS0.58063319
77ABL10.56470537
78BMX0.56394074
79GSK3A0.55050296
80MAP3K70.53985211
81FRK0.53895166
82MAP2K20.53551701
83MATK0.53531987
84MARK20.53395077
85MAPK70.53043054
86EGFR0.51553378
87CDK60.51396026
88CLK10.49940880
89PRKCQ0.48966779
90TTN0.48536118
91BRD40.48510889
92IRAK20.48333677
93PDPK10.47547781
94PIK3CA0.43711209
95SGK30.43218514
96HIPK20.41609586
97RPS6KC10.41559774
98RPS6KL10.41559774
99CAMKK20.41065251
100ERBB30.39553234
101NEK60.39209568
102SGK20.38745561
103YES10.38107734
104PRKCD0.37971314
105MELK0.37772579
106TIE10.36749155
107CDK90.36600363
108PRKD20.36151325
109FLT30.35981542
110MAP2K60.35462285
111PTK2B0.35233111
112STK30.34954055
113INSR0.34676459
114IGF1R0.33918050
115RPS6KA60.32082048
116PBK0.31895470
117MAP3K10.31788009
118MAP3K50.29191540
119RPS6KA50.26774409
120RPS6KA10.25275346
121PKN10.25213360
122MAPK120.24659089
123MAPK40.23591064
124MAPK30.23006281
125STK240.22695546
126LRRK20.22247384
127PRKG20.22068374
128DMPK0.21997028
129KDR0.21377358

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17308495
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.97895435
3Graft-versus-host disease_Homo sapiens_hsa053322.88404587
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.84658000
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77045785
6Allograft rejection_Homo sapiens_hsa053302.73649746
7Osteoclast differentiation_Homo sapiens_hsa043802.61109982
8Staphylococcus aureus infection_Homo sapiens_hsa051502.43139073
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38269588
10TNF signaling pathway_Homo sapiens_hsa046682.33391664
11Malaria_Homo sapiens_hsa051442.31537254
12Legionellosis_Homo sapiens_hsa051342.29767576
13Pertussis_Homo sapiens_hsa051332.16884766
14Measles_Homo sapiens_hsa051622.05486098
15Asthma_Homo sapiens_hsa053102.05449860
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95087712
17Rheumatoid arthritis_Homo sapiens_hsa053231.91761287
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.88815749
19African trypanosomiasis_Homo sapiens_hsa051431.85307614
20B cell receptor signaling pathway_Homo sapiens_hsa046621.79347916
21Toxoplasmosis_Homo sapiens_hsa051451.78597609
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75526396
23Influenza A_Homo sapiens_hsa051641.74290135
24Tuberculosis_Homo sapiens_hsa051521.73800745
25Hematopoietic cell lineage_Homo sapiens_hsa046401.70509072
26Type I diabetes mellitus_Homo sapiens_hsa049401.65945450
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59235390
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54388929
29T cell receptor signaling pathway_Homo sapiens_hsa046601.52864756
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.50454897
31Autoimmune thyroid disease_Homo sapiens_hsa053201.44598135
32Apoptosis_Homo sapiens_hsa042101.43686320
33Salmonella infection_Homo sapiens_hsa051321.37440007
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32692996
35Herpes simplex infection_Homo sapiens_hsa051681.31552409
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25378004
37Chemokine signaling pathway_Homo sapiens_hsa040621.22711073
38Primary immunodeficiency_Homo sapiens_hsa053401.21810895
39Antigen processing and presentation_Homo sapiens_hsa046121.20493869
40Shigellosis_Homo sapiens_hsa051311.15151399
41Hepatitis B_Homo sapiens_hsa051611.13054330
42Hepatitis C_Homo sapiens_hsa051601.07853201
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02868369
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.00899428
45Amoebiasis_Homo sapiens_hsa051460.99545760
46Lysosome_Homo sapiens_hsa041420.98579871
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96407744
48Phagosome_Homo sapiens_hsa041450.94924446
49Chronic myeloid leukemia_Homo sapiens_hsa052200.91315787
50Viral myocarditis_Homo sapiens_hsa054160.89632308
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87142148
52Acute myeloid leukemia_Homo sapiens_hsa052210.87053682
53Small cell lung cancer_Homo sapiens_hsa052220.83132468
54Prolactin signaling pathway_Homo sapiens_hsa049170.80607270
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.79845712
56Other glycan degradation_Homo sapiens_hsa005110.79759508
57Pancreatic cancer_Homo sapiens_hsa052120.70291047
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70137266
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.67363203
60* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67143219
61Platelet activation_Homo sapiens_hsa046110.67088411
62Type II diabetes mellitus_Homo sapiens_hsa049300.67025445
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.66132174
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64252580
65Epstein-Barr virus infection_Homo sapiens_hsa051690.64144097
66Non-small cell lung cancer_Homo sapiens_hsa052230.60202104
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57825669
68HTLV-I infection_Homo sapiens_hsa051660.56654880
69Insulin resistance_Homo sapiens_hsa049310.54313921
70MicroRNAs in cancer_Homo sapiens_hsa052060.52123358
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50748177
72Caffeine metabolism_Homo sapiens_hsa002320.50542837
73Prion diseases_Homo sapiens_hsa050200.49241339
74FoxO signaling pathway_Homo sapiens_hsa040680.49026838
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48562134
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48107925
77Dorso-ventral axis formation_Homo sapiens_hsa043200.47742428
78Circadian rhythm_Homo sapiens_hsa047100.47223057
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46023737
80Notch signaling pathway_Homo sapiens_hsa043300.45708065
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45033293
82Proteoglycans in cancer_Homo sapiens_hsa052050.44820798
83MAPK signaling pathway_Homo sapiens_hsa040100.44381723
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.43913776
85GnRH signaling pathway_Homo sapiens_hsa049120.42911470
86Complement and coagulation cascades_Homo sapiens_hsa046100.42794901
87Bladder cancer_Homo sapiens_hsa052190.41441380
88Choline metabolism in cancer_Homo sapiens_hsa052310.41351935
89Prostate cancer_Homo sapiens_hsa052150.41141691
90Viral carcinogenesis_Homo sapiens_hsa052030.39429328
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38412347
92mTOR signaling pathway_Homo sapiens_hsa041500.38253360
93VEGF signaling pathway_Homo sapiens_hsa043700.36912165
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36384879
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.36164024
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35604110
97HIF-1 signaling pathway_Homo sapiens_hsa040660.33339505
98Focal adhesion_Homo sapiens_hsa045100.32258220
99ECM-receptor interaction_Homo sapiens_hsa045120.31434127
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29820180
101Arachidonic acid metabolism_Homo sapiens_hsa005900.29146015
102Inositol phosphate metabolism_Homo sapiens_hsa005620.28790330
103ErbB signaling pathway_Homo sapiens_hsa040120.27623740
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27525267
105Adherens junction_Homo sapiens_hsa045200.27251417
106Mineral absorption_Homo sapiens_hsa049780.27112681
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25281397
108Endocytosis_Homo sapiens_hsa041440.23815285
109Renal cell carcinoma_Homo sapiens_hsa052110.23198620
110p53 signaling pathway_Homo sapiens_hsa041150.22966654
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22918665
112Sphingolipid metabolism_Homo sapiens_hsa006000.22117079
113Pathways in cancer_Homo sapiens_hsa052000.21431364
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21033800
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20633485

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »