NFKBIE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.49290688
2antigen processing and presentation of endogenous antigen (GO:0019883)5.28742393
3positive regulation of gamma-delta T cell activation (GO:0046645)5.25817280
4regulation of interleukin-12 biosynthetic process (GO:0045075)5.18850867
5NIK/NF-kappaB signaling (GO:0038061)5.10130354
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76630724
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76630724
8response to muramyl dipeptide (GO:0032495)4.60851732
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43489728
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.43489728
11modulation by symbiont of host immune response (GO:0052553)4.43489728
12positive regulation by symbiont of host defense response (GO:0052509)4.43489728
13modulation by symbiont of host defense response (GO:0052031)4.43489728
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43489728
15neutrophil activation involved in immune response (GO:0002283)4.37240468
16regulation of vitamin D biosynthetic process (GO:0060556)4.33269922
17immunoglobulin mediated immune response (GO:0016064)4.18930891
18response to peptidoglycan (GO:0032494)4.04386176
19regulation of dendritic cell antigen processing and presentation (GO:0002604)4.04247022
20myeloid dendritic cell differentiation (GO:0043011)3.96814444
21interferon-gamma-mediated signaling pathway (GO:0060333)3.93291752
22positive regulation of antigen processing and presentation (GO:0002579)3.91803144
23cellular response to type I interferon (GO:0071357)3.89468247
24type I interferon signaling pathway (GO:0060337)3.89468247
25response to type I interferon (GO:0034340)3.88192033
26positive regulation of interferon-alpha production (GO:0032727)3.86678928
27regulation of gamma-delta T cell activation (GO:0046643)3.86189898
28positive regulation of interleukin-12 production (GO:0032735)3.85189412
29myeloid dendritic cell activation (GO:0001773)3.75853684
30regulation of interferon-alpha production (GO:0032647)3.70412747
31regulation of gamma-delta T cell differentiation (GO:0045586)3.69487952
32granulocyte activation (GO:0036230)3.68153610
33regulation of cytokine secretion involved in immune response (GO:0002739)3.67441412
34neutrophil activation (GO:0042119)3.66441861
35regulation of B cell receptor signaling pathway (GO:0050855)3.65233237
36defense response to protozoan (GO:0042832)3.63706797
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.55305404
38macrophage activation involved in immune response (GO:0002281)3.54044980
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.52728125
40negative regulation of myeloid cell apoptotic process (GO:0033033)3.49946489
41cellular response to interferon-beta (GO:0035458)3.48920659
42regulation of T-helper 1 cell differentiation (GO:0045625)3.45987331
43leukocyte aggregation (GO:0070486)3.45471298
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45233214
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44873812
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44752351
47regulation of interferon-beta biosynthetic process (GO:0045357)3.44503022
48positive regulation of B cell differentiation (GO:0045579)3.42977864
49regulation of vitamin metabolic process (GO:0030656)3.41012619
50germinal center formation (GO:0002467)3.40677999
51regulation of podosome assembly (GO:0071801)3.40635233
52respiratory burst (GO:0045730)3.38158822
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.35203456
54T cell migration (GO:0072678)3.35014880
55regulation of antigen processing and presentation (GO:0002577)3.33751773
56regulation of alpha-beta T cell proliferation (GO:0046640)3.32133065
57detection of other organism (GO:0098543)3.31759448
58regulation of interleukin-12 production (GO:0032655)3.31609680
59response to protozoan (GO:0001562)3.28173868
60regulation of B cell differentiation (GO:0045577)3.28014309
61detection of bacterium (GO:0016045)3.25136989
62negative regulation of cytokine production involved in immune response (GO:0002719)3.25085876
63positive regulation of heat generation (GO:0031652)3.24993499
64B cell mediated immunity (GO:0019724)3.22646091
65regulation of chemokine biosynthetic process (GO:0045073)3.21438266
66B cell receptor signaling pathway (GO:0050853)3.18721090
67natural killer cell mediated immunity (GO:0002228)3.18304299
68natural killer cell mediated cytotoxicity (GO:0042267)3.18304299
69regulation of mononuclear cell migration (GO:0071675)3.18047349
70positive regulation of humoral immune response (GO:0002922)3.16087352
71negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15290353
72cellular response to zinc ion (GO:0071294)3.14783431
73regulation of chronic inflammatory response (GO:0002676)3.13877071
74positive regulation of interleukin-2 production (GO:0032743)3.13748003
75positive regulation of interferon-beta production (GO:0032728)3.13605669
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13580271
77positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.12379516
78mature B cell differentiation (GO:0002335)3.11939168
79positive regulation of chemokine biosynthetic process (GO:0045080)3.10992056
80dendritic cell differentiation (GO:0097028)3.10236056
81positive thymic T cell selection (GO:0045059)3.09291690
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08499064
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08432198
84activation of MAPKKK activity (GO:0000185)3.07800624
85negative thymic T cell selection (GO:0045060)3.07586072
86T-helper 1 type immune response (GO:0042088)3.07472948
87response to interferon-beta (GO:0035456)3.05246480
88regulation of fever generation (GO:0031620)3.03512142
89regulation of interleukin-2 biosynthetic process (GO:0045076)3.03223348
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.02847134
91positive regulation of natural killer cell differentiation (GO:0032825)3.02406823
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02190740
93negative regulation of cell killing (GO:0031342)3.02190740
94myeloid cell activation involved in immune response (GO:0002275)3.01295026
95positive regulation of type 2 immune response (GO:0002830)3.01258348
96positive regulation of cytokine biosynthetic process (GO:0042108)2.99255235
97negative T cell selection (GO:0043383)2.96963108
98detection of molecule of bacterial origin (GO:0032490)2.96755971
99response to host immune response (GO:0052572)2.96485352
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96485352
101negative regulation of erythrocyte differentiation (GO:0045647)2.96307880
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.96224682
103glycosphingolipid catabolic process (GO:0046479)2.96222821
104response to interferon-gamma (GO:0034341)2.96002731
105tolerance induction (GO:0002507)2.95099966
106negative regulation of interleukin-12 production (GO:0032695)2.94871433
107cellular response to interferon-gamma (GO:0071346)2.94592258
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92705114
109detection of external biotic stimulus (GO:0098581)2.89672455
110monocyte chemotaxis (GO:0002548)2.88046871
111cellular response to lipopolysaccharide (GO:0071222)2.87787727
112leukocyte cell-cell adhesion (GO:0007159)2.87683803
113regulation of interferon-gamma biosynthetic process (GO:0045072)2.87451527
114positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86364073
115regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84700954
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.84615638
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84131989
118oligosaccharide catabolic process (GO:0009313)2.83692826
119positive regulation of interleukin-17 production (GO:0032740)2.82215816
120regulation of interleukin-17 production (GO:0032660)2.82172315
121cellular response to molecule of bacterial origin (GO:0071219)2.82024460
122positive regulation of NF-kappaB import into nucleus (GO:0042346)2.81534405
123myeloid leukocyte activation (GO:0002274)2.80403187
124cellular response to exogenous dsRNA (GO:0071360)2.80202768
125cytokine secretion (GO:0050663)2.79711210
126regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78999337
127macrophage activation (GO:0042116)2.78967447
128positive regulation of isotype switching (GO:0045830)2.78967017
129positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.78538994
130response to host defenses (GO:0052200)2.78366376
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78366376
132response to host (GO:0075136)2.78366376
133cellular extravasation (GO:0045123)2.78221775
134positive regulation of immunoglobulin mediated immune response (GO:0002891)2.77804784
135positive regulation of B cell mediated immunity (GO:0002714)2.77804784
136regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75238479
137positive regulation of interleukin-10 production (GO:0032733)2.74754549
138mature B cell differentiation involved in immune response (GO:0002313)2.72381570
139regulation of T-helper cell differentiation (GO:0045622)2.72267830
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.70396169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.71683114
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.65587746
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.76321530
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.68804032
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.48279215
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.22103944
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.04938644
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.84226483
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.67069682
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63199191
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42951584
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22808232
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20339603
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.17254737
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.04496555
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99432907
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84499150
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79844789
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49205185
20MYB_26560356_Chip-Seq_TH2_Human2.40420630
21RUNX_20019798_ChIP-Seq_JUKART_Human2.34493215
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33946904
23* MAF_26560356_Chip-Seq_TH1_Human2.23598070
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21626368
25SPI1_23547873_ChIP-Seq_NB4_Human2.17668564
26MYC_22102868_ChIP-Seq_BL_Human2.16823193
27VDR_21846776_ChIP-Seq_THP-1_Human2.16778298
28SCL_19346495_ChIP-Seq_HPC-7_Human2.13776011
29VDR_24763502_ChIP-Seq_THP-1_Human2.10608009
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10596826
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10564337
32MYB_26560356_Chip-Seq_TH1_Human2.02340520
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00899573
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96398249
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.86001950
36* LXR_22292898_ChIP-Seq_THP-1_Human1.84309173
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73719380
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68892222
39UTX_26944678_Chip-Seq_JUKART_Human1.67120977
40* SPI1_23127762_ChIP-Seq_K562_Human1.64636928
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63973429
42TCF7_22412390_ChIP-Seq_EML_Mouse1.62235735
43PU_27001747_Chip-Seq_BMDM_Mouse1.61891721
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48751817
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.48158624
46VDR_24787735_ChIP-Seq_THP-1_Human1.47748540
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47295780
48GATA3_27048872_Chip-Seq_THYMUS_Human1.46258317
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46055072
50* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43530326
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38107441
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38025315
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33937938
54MAF_26560356_Chip-Seq_TH2_Human1.30584264
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29794216
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29409541
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26191500
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24207712
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.23672408
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.22764559
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22312550
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.22065303
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17143622
64GATA3_26560356_Chip-Seq_TH2_Human1.16952677
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16350371
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13536724
67GATA1_22025678_ChIP-Seq_K562_Human1.11843137
68BCL6_27268052_Chip-Seq_Bcells_Human1.11455808
69BCOR_27268052_Chip-Seq_Bcells_Human1.11056608
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10979666
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10752120
72KDM2B_26808549_Chip-Seq_DND41_Human1.10414543
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08044220
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07503978
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07247869
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.07051949
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05162002
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03721757
79* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03527145
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03306295
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02643977
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02610204
83RACK7_27058665_Chip-Seq_MCF-7_Human1.02080199
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00951631
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98550932
86SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96999826
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.96672546
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92665072
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89970443
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.88937286
91STAT1_20625510_ChIP-Seq_HELA_Human0.88869808
92* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87121772
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.86404565
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86060076
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85878078
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.83978445
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82851426
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82559172
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81537900
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80983561
101TFEB_21752829_ChIP-Seq_HELA_Human0.80761351
102E2F7_22180533_ChIP-Seq_HELA_Human0.80497552
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74216670
104EGR1_19032775_ChIP-ChIP_M12_Human0.74086952
105NCOR1_26117541_ChIP-Seq_K562_Human0.71633799
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71474079
107HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67669076
108SMRT_27268052_Chip-Seq_Bcells_Human0.66423252
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.65748871
110GATA2_19941826_ChIP-Seq_K562_Human0.64858279
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64293840
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63536152
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.63258868
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.63258868
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62081725
116GATA1_19941826_ChIP-Seq_K562_Human0.60960418
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60547704
118SPI1_20517297_ChIP-Seq_HL60_Human0.60227884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.01120339
2MP0000685_abnormal_immune_system3.91481062
3MP0009785_altered_susceptibility_to3.65585017
4MP0003436_decreased_susceptibility_to3.57259293
5MP0005387_immune_system_phenotype3.43268150
6MP0001790_abnormal_immune_system3.43268150
7MP0005671_abnormal_response_to3.30705549
8MP0005000_abnormal_immune_tolerance3.30059069
9MP0004510_myositis3.17155320
10MP0003303_peritoneal_inflammation3.17141346
11* MP0001800_abnormal_humoral_immune3.16732514
12MP0002148_abnormal_hypersensitivity_rea3.13864094
13* MP0002452_abnormal_antigen_presenting2.92253500
14MP0005025_abnormal_response_to2.88899437
15MP0002419_abnormal_innate_immunity2.83975515
16* MP0002723_abnormal_immune_serum2.80329150
17* MP0001819_abnormal_immune_cell2.53987077
18* MP0002420_abnormal_adaptive_immunity2.53274770
19MP0003724_increased_susceptibility_to2.45633823
20MP0006082_CNS_inflammation2.38221156
21MP0002139_abnormal_hepatobiliary_system2.31049817
22MP0001853_heart_inflammation2.25376826
23MP0002405_respiratory_system_inflammati2.22077098
24MP0004947_skin_inflammation2.10551684
25MP0002254_reproductive_system_inflammat2.04122502
26* MP0002398_abnormal_bone_marrow2.03858594
27MP0010155_abnormal_intestine_physiology2.02273603
28* MP0000716_abnormal_immune_system2.00725393
29MP0003763_abnormal_thymus_physiology2.00441372
30MP0005451_abnormal_body_composition1.96913309
31MP0002166_altered_tumor_susceptibility1.93338212
32MP0001845_abnormal_inflammatory_respons1.90236183
33MP0002138_abnormal_hepatobiliary_system1.88371480
34MP0001873_stomach_inflammation1.87491869
35MP0002006_tumorigenesis1.85514328
36MP0005464_abnormal_platelet_physiology1.81171415
37MP0005310_abnormal_salivary_gland1.76884267
38MP0009278_abnormal_bone_marrow1.75147321
39MP0001533_abnormal_skeleton_physiology1.74019535
40MP0009333_abnormal_splenocyte_physiolog1.71873104
41MP0000689_abnormal_spleen_morphology1.68021361
42MP0003300_gastrointestinal_ulcer1.64090234
43* MP0002429_abnormal_blood_cell1.61238824
44MP0002722_abnormal_immune_system1.59441484
45MP0009764_decreased_sensitivity_to1.56023602
46MP0003806_abnormal_nucleotide_metabolis1.52995466
47MP0008469_abnormal_protein_level1.51651840
48MP0003448_altered_tumor_morphology1.46913100
49MP0005397_hematopoietic_system_phenotyp1.46295878
50MP0001545_abnormal_hematopoietic_system1.46295878
51MP0005058_abnormal_lysosome_morphology1.31931560
52MP0000703_abnormal_thymus_morphology1.26731196
53MP0000343_altered_response_to1.21945821
54MP0008004_abnormal_stomach_pH1.20309528
55MP0005076_abnormal_cell_differentiation1.19656084
56MP0000858_altered_metastatic_potential1.19476448
57MP0002933_joint_inflammation1.19112550
58MP0003866_abnormal_defecation1.18492386
59MP0004808_abnormal_hematopoietic_stem1.17608321
60MP0003172_abnormal_lysosome_physiology1.16408255
61MP0002998_abnormal_bone_remodeling1.15501297
62MP0010352_gastrointestinal_tract_polyps1.14135954
63MP0002396_abnormal_hematopoietic_system1.14097063
64MP0003656_abnormal_erythrocyte_physiolo1.10130729
65MP0003075_altered_response_to1.05116259
66MP0000569_abnormal_digit_pigmentation1.02474237
67MP0001348_abnormal_lacrimal_gland1.00451536
68MP0002277_abnormal_respiratory_mucosa0.99955679
69MP0003183_abnormal_peptide_metabolism0.99758188
70MP0001851_eye_inflammation0.97661971
71MP0003453_abnormal_keratinocyte_physiol0.95909226
72MP0005174_abnormal_tail_pigmentation0.95302299
73MP0010307_abnormal_tumor_latency0.91153548
74MP0000604_amyloidosis0.91021788
75MP0003690_abnormal_glial_cell0.90501057
76MP0002332_abnormal_exercise_endurance0.89493714
77MP0005166_decreased_susceptibility_to0.89143619
78MP0003828_pulmonary_edema0.88024543
79MP0009763_increased_sensitivity_to0.86709505
80MP0000490_abnormal_crypts_of0.85124609
81MP0000465_gastrointestinal_hemorrhage0.85069310
82MP0003091_abnormal_cell_migration0.82142724
83MP0005390_skeleton_phenotype0.79710415
84MP0000249_abnormal_blood_vessel0.78431220
85MP0006054_spinal_hemorrhage0.77619074
86MP0008874_decreased_physiological_sensi0.76098605
87MP0005165_increased_susceptibility_to0.73913756
88MP0003191_abnormal_cellular_cholesterol0.72424701
89MP0009840_abnormal_foam_cell0.69938974
90MP0003329_amyloid_beta_deposits0.68913813
91MP0003566_abnormal_cell_adhesion0.68799633
92MP0002136_abnormal_kidney_physiology0.68217568
93MP0001663_abnormal_digestive_system0.67144454
94MP0004883_abnormal_blood_vessel0.66496174
95MP0002019_abnormal_tumor_incidence0.66086499
96MP0000371_diluted_coat_color0.64706208
97MP0005164_abnormal_response_to0.63808869
98MP0008057_abnormal_DNA_replication0.62808587
99MP0003045_fibrosis0.62064627
100MP0002877_abnormal_melanocyte_morpholog0.61912137
101MP0000920_abnormal_myelination0.61239480
102MP0009765_abnormal_xenobiotic_induced0.57926321
103MP0005647_abnormal_sex_gland0.56826445
104MP0000015_abnormal_ear_pigmentation0.56598450
105MP0003795_abnormal_bone_structure0.56083588
106MP0003195_calcinosis0.53322724
107MP0005023_abnormal_wound_healing0.52832569
108MP0001542_abnormal_bone_strength0.51816043
109MP0005167_abnormal_blood-brain_barrier0.50791648
110MP0008260_abnormal_autophagy0.50643674
111MP0004782_abnormal_surfactant_physiolog0.50620537
112MP0000767_abnormal_smooth_muscle0.49907259
113MP0002693_abnormal_pancreas_physiology0.49736078
114MP0000609_abnormal_liver_physiology0.47794852
115MP0001191_abnormal_skin_condition0.47327310
116MP0001881_abnormal_mammary_gland0.44587526

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.05502785
2Eczematoid dermatitis (HP:0000976)6.01378417
3Abnormality of glycolipid metabolism (HP:0010969)5.95303338
4Abnormality of liposaccharide metabolism (HP:0010968)5.95303338
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.95303338
6Recurrent bacterial skin infections (HP:0005406)5.74757025
7Elevated erythrocyte sedimentation rate (HP:0003565)5.55620876
8Myositis (HP:0100614)5.02683072
9Recurrent fungal infections (HP:0002841)4.71232168
10Mediastinal lymphadenopathy (HP:0100721)4.67453003
11Retrobulbar optic neuritis (HP:0100654)4.50810288
12Optic neuritis (HP:0100653)4.50810288
13Orchitis (HP:0100796)4.49699132
14Stomatitis (HP:0010280)4.35252984
15Recurrent gram-negative bacterial infections (HP:0005420)4.31852939
16Recurrent viral infections (HP:0004429)4.31473588
17Recurrent skin infections (HP:0001581)4.25448752
18Chronic mucocutaneous candidiasis (HP:0002728)4.24732613
19Recurrent cutaneous fungal infections (HP:0011370)4.24732613
20Abnormality of macrophages (HP:0004311)4.12238212
21Vasculitis (HP:0002633)4.08051582
22Agammaglobulinemia (HP:0004432)3.89120686
23Chronic otitis media (HP:0000389)3.88216641
24Loss of speech (HP:0002371)3.87696223
25Dysostosis multiplex (HP:0000943)3.83083483
26Disinhibition (HP:0000734)3.68457311
27Autoimmune thrombocytopenia (HP:0001973)3.65968226
28Cellulitis (HP:0100658)3.64456963
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.61157401
30Meningitis (HP:0001287)3.57978239
31Recurrent bronchitis (HP:0002837)3.47769416
32Pulmonary infiltrates (HP:0002113)3.47328985
33Colitis (HP:0002583)3.46561023
34Panhypogammaglobulinemia (HP:0003139)3.36090832
35Obstructive lung disease (HP:0006536)3.35741062
36Chronic obstructive pulmonary disease (HP:0006510)3.35741062
37Gingivitis (HP:0000230)3.32795189
38Inflammation of the large intestine (HP:0002037)3.26293868
39Increased IgM level (HP:0003496)3.22492243
40Nasal polyposis (HP:0100582)3.20967605
41Interstitial pulmonary disease (HP:0006530)3.16289363
42Gastrointestinal stroma tumor (HP:0100723)3.16179827
43Pustule (HP:0200039)3.15214666
44Abnormality of T cell number (HP:0011839)3.13060433
45Gastrointestinal inflammation (HP:0004386)3.09041343
46Leukocytosis (HP:0001974)3.02217295
47Mutism (HP:0002300)3.01868981
48Keratoconjunctivitis (HP:0001096)2.94239396
49T lymphocytopenia (HP:0005403)2.94224127
50Arterial thrombosis (HP:0004420)2.92697979
51Hematochezia (HP:0002573)2.91733178
52Osteomyelitis (HP:0002754)2.91560470
53Abnormality of T cells (HP:0002843)2.89129911
54Keratoconjunctivitis sicca (HP:0001097)2.87779827
55Abnormality of the nasal mucosa (HP:0000433)2.86316222
56Increased serum ferritin (HP:0003281)2.75400961
57Periodontitis (HP:0000704)2.74282651
58Thyroiditis (HP:0100646)2.73783190
59Glomerulonephritis (HP:0000099)2.72739202
60IgM deficiency (HP:0002850)2.72671619
61Abnormality of T cell physiology (HP:0011840)2.72582815
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72135481
63Gastrointestinal infarctions (HP:0005244)2.70834524
64Hemoptysis (HP:0002105)2.69816550
65Eosinophilia (HP:0001880)2.68522891
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68012225
67Abnormality of polysaccharide metabolism (HP:0011012)2.68012225
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68012225
69Emphysema (HP:0002097)2.65622961
70Hypergammaglobulinemia (HP:0010702)2.65205944
71Vacuolated lymphocytes (HP:0001922)2.62684252
72Recurrent pneumonia (HP:0006532)2.61432401
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.58927843
74Thrombocytosis (HP:0001894)2.58729106
75Urticaria (HP:0001025)2.57127562
76Axonal loss (HP:0003447)2.56361376
77Lymphopenia (HP:0001888)2.56155623
78Recurrent lower respiratory tract infections (HP:0002783)2.54658623
79Purpura (HP:0000979)2.54434807
80Basal ganglia calcification (HP:0002135)2.53025166
81Urinary glycosaminoglycan excretion (HP:0003541)2.49239894
82Mucopolysacchariduria (HP:0008155)2.49239894
83Nuclear cataract (HP:0100018)2.47829056
84Encephalitis (HP:0002383)2.47261135
85IgG deficiency (HP:0004315)2.46381460
86Abnormality of eosinophils (HP:0001879)2.45036589
87Neurofibrillary tangles (HP:0002185)2.42706371
88Increased IgE level (HP:0003212)2.41635350
89Apathy (HP:0000741)2.40407906
90Neuronal loss in central nervous system (HP:0002529)2.37046049
91Upper motor neuron abnormality (HP:0002127)2.36802228
92Diminished motivation (HP:0000745)2.36479946
93Gingival bleeding (HP:0000225)2.35539905
94Spontaneous hematomas (HP:0007420)2.35496977
95Hypertensive crisis (HP:0100735)2.33982003
96Chronic sinusitis (HP:0011109)2.31736428
97Chronic diarrhea (HP:0002028)2.30487960
98IgA deficiency (HP:0002720)2.28484487
99Gangrene (HP:0100758)2.28235903
100Severe combined immunodeficiency (HP:0004430)2.26099547
101Granulocytopenia (HP:0001913)2.25978979
102Hepatosplenomegaly (HP:0001433)2.25211667
103Combined immunodeficiency (HP:0005387)2.24971191
104Amyloidosis (HP:0011034)2.24379362
105Personality changes (HP:0000751)2.22919974
106Prostate neoplasm (HP:0100787)2.22120166
107Increased cerebral lipofuscin (HP:0011813)2.20330649
108B lymphocytopenia (HP:0010976)2.19980338
109Abnormality of B cell number (HP:0010975)2.19980338
110Premature loss of primary teeth (HP:0006323)2.19646492
111Arthralgia (HP:0002829)2.19489323
112Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19153704
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18072547
114Skin ulcer (HP:0200042)2.16827020
115Restrictive lung disease (HP:0002091)2.16631698
116Systemic lupus erythematosus (HP:0002725)2.15822818
117Myocardial infarction (HP:0001658)2.15454019
118Thick nail (HP:0001805)2.14841769
119Polyneuropathy (HP:0001271)2.14356358
120Tetraparesis (HP:0002273)2.14031416
121Sepsis (HP:0100806)2.12029147
122Abnormality of iron homeostasis (HP:0011031)2.09712654
123Recurrent sinusitis (HP:0011108)2.09553764
124Joint swelling (HP:0001386)2.08534302
125Increased neuronal autofluorescent lipopigment (HP:0002074)2.06970598
126Progressive neurologic deterioration (HP:0002344)2.06431197
127Agnosia (HP:0010524)2.03937339
128Chest pain (HP:0100749)2.03557983
129Abnormality of the pleura (HP:0002103)2.02574662
130Petechiae (HP:0000967)2.01841287
131Abnormality of the fingertips (HP:0001211)2.01638160
132Thoracic kyphosis (HP:0002942)1.96729782
133Autoimmune hemolytic anemia (HP:0001890)1.95501850
134Verrucae (HP:0200043)1.94090701
135Papilloma (HP:0012740)1.94090701
136Anorexia (HP:0002039)1.89499006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.98906555
2MAP4K13.98824226
3TBK13.65736318
4IRAK33.21773331
5RIPK43.20758257
6TYK23.16428736
7PRPF4B3.07288302
8JAK32.97581413
9IKBKE2.92742234
10IKBKB2.80048299
11BLK2.69785294
12TXK2.63888570
13IRAK42.55931867
14TAOK22.41112893
15JAK12.25599700
16MAP3K132.19621759
17KIT2.15781718
18CHUK2.05547572
19DDR21.97612977
20ERN11.88870688
21ZAP701.84305086
22GRK71.81890073
23BTK1.71396541
24SYK1.70191918
25TAOK11.67720227
26MAP3K101.63014522
27CSF1R1.58706977
28TAOK31.58120620
29EPHB11.50779579
30RPS6KA41.45313981
31CSK1.45205718
32MAP3K31.44249898
33TEC1.43609683
34PIM11.34222291
35MST41.33186623
36CDC42BPA1.32045174
37HCK1.31166326
38STK101.29927581
39FGFR41.29468471
40LCK1.25434305
41GRK61.24527523
42FGFR31.20928498
43TGFBR21.20577110
44SIK21.17951998
45ITK1.15758813
46FLT31.14126400
47PIM21.12134681
48LYN1.11259571
49SMG11.07487874
50NME21.07420752
51ARAF1.06184392
52JAK21.02456309
53CLK11.01200124
54SIK30.99438209
55TESK20.98902134
56EPHA30.95523015
57MARK30.93608192
58NLK0.91785904
59LRRK20.88609903
60MATK0.86121726
61MAP2K30.80857009
62BMPR20.77435339
63FES0.73863163
64PTK60.72218790
65NEK90.65224951
66CDK120.63130057
67EIF2AK20.60736307
68FGR0.57911465
69IRAK10.57646644
70PBK0.57464397
71BMX0.57045299
72KDR0.56746930
73TNK20.55739849
74STK40.54377765
75PRKCQ0.53225059
76TYRO30.51060847
77PDPK10.50967107
78ABL10.49779464
79MAP3K80.49603009
80CAMK1D0.48442477
81RPS6KL10.47704649
82RPS6KC10.47704649
83EGFR0.47125967
84ICK0.46792796
85MAPK70.46523307
86STK240.45683084
87PRKCD0.44970490
88MAPKAPK20.44399042
89MAP3K110.44093344
90DAPK30.42473667
91RPS6KA50.42285417
92MAP3K50.38148202
93BRAF0.38061617
94EEF2K0.37951188
95CAMKK20.37811272
96MAP3K90.37443808
97ACVR1B0.36924382
98MAPK110.36675082
99MAPK120.36581947
100ADRBK20.32416639
101RPS6KA20.32279253
102TGFBR10.31442042
103CDK40.31413426
104KSR20.31109865
105RPS6KA60.30629024
106MAP2K60.30073203
107ALK0.29994945
108MELK0.29714513
109MAP3K10.29442632
110TRPM70.29440810
111HIPK20.28822914
112PDGFRB0.28240742
113PRKD20.28008568
114TRIB30.27106563
115MARK20.26268441
116PDK10.26126663
117TLK10.25923723
118SCYL20.25728277
119SIK10.25292271
120INSR0.25262710
121RIPK10.24053459
122RPS6KA10.23940376
123MAP3K70.23403821
124CDK90.22605136
125FYN0.21629186
126YES10.20501837
127MOS0.17556172
128MAPK30.17490564
129IRAK20.16925441
130ABL20.16850933
131CDK60.15820155
132MAPK40.15137219
133PKN10.14820300
134IGF1R0.13243793

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.27163162
2Leishmaniasis_Homo sapiens_hsa051403.23797131
3Graft-versus-host disease_Homo sapiens_hsa053322.78661370
4Primary immunodeficiency_Homo sapiens_hsa053402.72025716
5Allograft rejection_Homo sapiens_hsa053302.66675103
6Osteoclast differentiation_Homo sapiens_hsa043802.63794036
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57290444
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.52525761
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50861646
10Measles_Homo sapiens_hsa051622.37195463
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.35841925
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34251819
13* B cell receptor signaling pathway_Homo sapiens_hsa046622.29306299
14Legionellosis_Homo sapiens_hsa051342.27937594
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25977126
16Antigen processing and presentation_Homo sapiens_hsa046122.10858298
17TNF signaling pathway_Homo sapiens_hsa046682.10330622
18Malaria_Homo sapiens_hsa051441.95926907
19Pertussis_Homo sapiens_hsa051331.92436642
20Tuberculosis_Homo sapiens_hsa051521.87303464
21Influenza A_Homo sapiens_hsa051641.84701479
22Staphylococcus aureus infection_Homo sapiens_hsa051501.79781006
23Toxoplasmosis_Homo sapiens_hsa051451.79529495
24Herpes simplex infection_Homo sapiens_hsa051681.79283164
25Hematopoietic cell lineage_Homo sapiens_hsa046401.76489781
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72627033
27Asthma_Homo sapiens_hsa053101.72523209
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.60380415
29Apoptosis_Homo sapiens_hsa042101.59100549
30Type I diabetes mellitus_Homo sapiens_hsa049401.58801772
31Rheumatoid arthritis_Homo sapiens_hsa053231.58189032
32* T cell receptor signaling pathway_Homo sapiens_hsa046601.53152410
33African trypanosomiasis_Homo sapiens_hsa051431.52874142
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50917897
35Chemokine signaling pathway_Homo sapiens_hsa040621.50565846
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45509933
37Shigellosis_Homo sapiens_hsa051311.42178595
38Salmonella infection_Homo sapiens_hsa051321.39509191
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38233653
40Autoimmune thyroid disease_Homo sapiens_hsa053201.26141090
41Hepatitis B_Homo sapiens_hsa051611.24971382
42Viral myocarditis_Homo sapiens_hsa054161.20304252
43Acute myeloid leukemia_Homo sapiens_hsa052211.16502525
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14298331
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12061242
46Hepatitis C_Homo sapiens_hsa051601.08112822
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.99480449
48Chronic myeloid leukemia_Homo sapiens_hsa052200.97935227
49* Epstein-Barr virus infection_Homo sapiens_hsa051690.97871178
50Systemic lupus erythematosus_Homo sapiens_hsa053220.97861924
51Prolactin signaling pathway_Homo sapiens_hsa049170.96849040
52Bladder cancer_Homo sapiens_hsa052190.96568762
53Lysosome_Homo sapiens_hsa041420.90057179
54Phagosome_Homo sapiens_hsa041450.83957307
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78984298
56Pancreatic cancer_Homo sapiens_hsa052120.77142381
57Small cell lung cancer_Homo sapiens_hsa052220.76145700
58* Neurotrophin signaling pathway_Homo sapiens_hsa047220.72497109
59Viral carcinogenesis_Homo sapiens_hsa052030.72267018
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72199150
61HTLV-I infection_Homo sapiens_hsa051660.68502666
62Amoebiasis_Homo sapiens_hsa051460.66921675
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.66806153
64Other glycan degradation_Homo sapiens_hsa005110.65654521
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65534299
66Platelet activation_Homo sapiens_hsa046110.64582371
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59638302
68* Adipocytokine signaling pathway_Homo sapiens_hsa049200.54342659
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51233666
70Sphingolipid metabolism_Homo sapiens_hsa006000.49207965
71Notch signaling pathway_Homo sapiens_hsa043300.48816596
72Collecting duct acid secretion_Homo sapiens_hsa049660.48256129
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48046075
74VEGF signaling pathway_Homo sapiens_hsa043700.46357196
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45572499
76Insulin resistance_Homo sapiens_hsa049310.44216883
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43321741
78p53 signaling pathway_Homo sapiens_hsa041150.41366305
79HIF-1 signaling pathway_Homo sapiens_hsa040660.39528165
80MicroRNAs in cancer_Homo sapiens_hsa052060.36766768
81FoxO signaling pathway_Homo sapiens_hsa040680.36466426
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.36398410
83MAPK signaling pathway_Homo sapiens_hsa040100.35683846
84Complement and coagulation cascades_Homo sapiens_hsa046100.34199177
85Type II diabetes mellitus_Homo sapiens_hsa049300.33950722
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31665087
87Endocytosis_Homo sapiens_hsa041440.29621042
88Vibrio cholerae infection_Homo sapiens_hsa051100.29306099
89Fructose and mannose metabolism_Homo sapiens_hsa000510.28971499
90Galactose metabolism_Homo sapiens_hsa000520.28483848
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27767596
92Proteoglycans in cancer_Homo sapiens_hsa052050.26470686
93Prion diseases_Homo sapiens_hsa050200.24669507
94Colorectal cancer_Homo sapiens_hsa052100.24386027
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22394648
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20627004
97Non-small cell lung cancer_Homo sapiens_hsa052230.20473950
98GnRH signaling pathway_Homo sapiens_hsa049120.19800752
99Dorso-ventral axis formation_Homo sapiens_hsa043200.19206632
100Mineral absorption_Homo sapiens_hsa049780.19063133
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18832799
102Sulfur metabolism_Homo sapiens_hsa009200.17708560
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17522721
104Pathways in cancer_Homo sapiens_hsa052000.16928703
105Prostate cancer_Homo sapiens_hsa052150.16090371
106Caffeine metabolism_Homo sapiens_hsa002320.15188144
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15058368
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13656227
109mTOR signaling pathway_Homo sapiens_hsa041500.13603235
110Base excision repair_Homo sapiens_hsa034100.12358129
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.11592278
112Renal cell carcinoma_Homo sapiens_hsa052110.11186432
113Inositol phosphate metabolism_Homo sapiens_hsa005620.10180134

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