NFE2L3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)6.63878687
2positive regulation of chemokine secretion (GO:0090197)5.79072648
3regulation of chemokine secretion (GO:0090196)5.01115780
4dopamine transport (GO:0015872)4.95356294
5regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.76284675
6glycerophospholipid catabolic process (GO:0046475)4.55752758
7positive regulation of macrophage activation (GO:0043032)4.51075452
8cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.43486650
9regulation of gonadotropin secretion (GO:0032276)4.27766312
10astrocyte differentiation (GO:0048708)4.20278051
11endocrine hormone secretion (GO:0060986)4.14461024
12axoneme assembly (GO:0035082)4.11456224
13lactate metabolic process (GO:0006089)4.05131778
14aldehyde catabolic process (GO:0046185)3.99408425
15L-ascorbic acid metabolic process (GO:0019852)3.98518817
16regulation of cytokine production involved in inflammatory response (GO:1900015)3.84922241
17ubiquinone metabolic process (GO:0006743)3.82233818
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77003708
19positive regulation of mitotic sister chromatid separation (GO:1901970)3.77003708
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77003708
21epithelial cell fate commitment (GO:0072148)3.63225179
22negative regulation of macrophage differentiation (GO:0045650)3.59657813
23cell wall macromolecule catabolic process (GO:0016998)3.58301651
24early endosome to late endosome transport (GO:0045022)3.56796401
25photoreceptor cell differentiation (GO:0046530)3.49507902
26eye photoreceptor cell differentiation (GO:0001754)3.49507902
27kidney morphogenesis (GO:0060993)3.46578503
28nonmotile primary cilium assembly (GO:0035058)3.45518887
29insulin secretion (GO:0030073)3.38137776
30ubiquinone biosynthetic process (GO:0006744)3.37079148
31cellular ketone body metabolic process (GO:0046950)3.32294481
32catecholamine transport (GO:0051937)3.31317692
33regulation of interleukin-5 production (GO:0032674)3.28688948
34indolalkylamine metabolic process (GO:0006586)3.26644691
35estrogen biosynthetic process (GO:0006703)3.23856208
36cell wall macromolecule metabolic process (GO:0044036)3.21048866
37vitamin biosynthetic process (GO:0009110)3.20345545
38triglyceride homeostasis (GO:0070328)3.13729670
39acylglycerol homeostasis (GO:0055090)3.13729670
40response to follicle-stimulating hormone (GO:0032354)3.13437411
41positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.11524141
42DNA damage induced protein phosphorylation (GO:0006975)3.08798525
43dorsal/ventral axis specification (GO:0009950)3.06002116
44UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04760924
45regulation of acrosome reaction (GO:0060046)3.04473441
46Golgi to endosome transport (GO:0006895)3.04425918
47L-fucose catabolic process (GO:0042355)3.03549237
48fucose catabolic process (GO:0019317)3.03549237
49L-fucose metabolic process (GO:0042354)3.03549237
50behavioral response to nicotine (GO:0035095)3.03406629
51regulation of glucocorticoid secretion (GO:2000849)3.02238556
52photoreceptor cell maintenance (GO:0045494)2.99863113
53ketone body metabolic process (GO:1902224)2.98312801
54nephron epithelium morphogenesis (GO:0072088)2.94889591
55nephron tubule morphogenesis (GO:0072078)2.94889591
56retinal rod cell development (GO:0046548)2.94244410
57protein-chromophore linkage (GO:0018298)2.84853838
58cellular biogenic amine catabolic process (GO:0042402)2.84648462
59amine catabolic process (GO:0009310)2.84648462
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83967115
61negative regulation of neurotransmitter transport (GO:0051589)2.83518988
62epithelial cilium movement (GO:0003351)2.80464691
63regulation of hexokinase activity (GO:1903299)2.80370732
64regulation of glucokinase activity (GO:0033131)2.80370732
65negative regulation of complement activation (GO:0045916)2.78641902
66brain morphogenesis (GO:0048854)2.76729416
67negative regulation of protein activation cascade (GO:2000258)2.75988983
68quinone metabolic process (GO:1901661)2.75490881
69detection of calcium ion (GO:0005513)2.75087849
70quinone biosynthetic process (GO:1901663)2.73202973
71intra-Golgi vesicle-mediated transport (GO:0006891)2.73028042
72establishment of protein localization to Golgi (GO:0072600)2.72669947
73cilium movement (GO:0003341)2.71655997
74intraciliary transport (GO:0042073)2.71250980
75cellular response to sterol (GO:0036315)2.70100810
76cornea development in camera-type eye (GO:0061303)2.68449283
77phospholipid catabolic process (GO:0009395)2.68136815
78positive regulation of actin filament depolymerization (GO:0030836)2.66282777
79piRNA metabolic process (GO:0034587)2.63751923
80male meiosis (GO:0007140)2.63710849
81chemosensory behavior (GO:0007635)2.63054423
82regulation of endothelial cell differentiation (GO:0045601)2.61560845
83macroautophagy (GO:0016236)2.59912574
84regulation of cilium movement (GO:0003352)2.59577026
85cellular response to cholesterol (GO:0071397)2.58984363
86protein targeting to Golgi (GO:0000042)2.57591635
87endocrine pancreas development (GO:0031018)2.56424627
88toxin metabolic process (GO:0009404)2.56421869
89regulation of macrophage activation (GO:0043030)2.55049364
90cilium or flagellum-dependent cell motility (GO:0001539)2.54045832
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53869156
92short-chain fatty acid metabolic process (GO:0046459)2.50756845
93thyroid hormone metabolic process (GO:0042403)2.50119366
94cellular response to gonadotropin stimulus (GO:0071371)2.49486293
95negative regulation of circadian rhythm (GO:0042754)2.49280787
96uronic acid metabolic process (GO:0006063)2.44734905
97glucuronate metabolic process (GO:0019585)2.44734905
98alanine transport (GO:0032328)2.43421784
99calcium ion import (GO:0070509)2.43394740
100positive regulation of sodium ion transmembrane transport (GO:1902307)2.41542563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.97115409
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32212906
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.30497131
4ZNF274_21170338_ChIP-Seq_K562_Hela2.95329069
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.65649759
6IGF1R_20145208_ChIP-Seq_DFB_Human2.53413096
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50779536
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44222790
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.29603468
10VDR_22108803_ChIP-Seq_LS180_Human2.26790470
11TAF15_26573619_Chip-Seq_HEK293_Human2.25439271
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24689903
13GBX2_23144817_ChIP-Seq_PC3_Human2.12770514
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10974350
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07596556
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.89315069
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85995171
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84536146
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84337486
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84264734
21ER_23166858_ChIP-Seq_MCF-7_Human1.82998029
22FUS_26573619_Chip-Seq_HEK293_Human1.82882716
23SMAD4_21799915_ChIP-Seq_A2780_Human1.75309411
24EWS_26573619_Chip-Seq_HEK293_Human1.64415860
25P300_19829295_ChIP-Seq_ESCs_Human1.60606091
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58712740
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58100473
28RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55627573
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55199035
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55034745
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.54196704
32STAT3_23295773_ChIP-Seq_U87_Human1.54140339
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51427641
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49999912
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.49830416
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.48190455
37TCF4_23295773_ChIP-Seq_U87_Human1.45672617
38CRX_20693478_ChIP-Seq_RETINA_Mouse1.44868096
39BCAT_22108803_ChIP-Seq_LS180_Human1.44613902
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43992590
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42728779
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41861280
43AR_25329375_ChIP-Seq_VCAP_Human1.41790510
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41014374
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39870410
46CBP_20019798_ChIP-Seq_JUKART_Human1.39870410
47ELK1_19687146_ChIP-ChIP_HELA_Human1.38729274
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38159528
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37297971
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.37248233
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36328384
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34955438
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33400416
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33242960
55CDX2_22108803_ChIP-Seq_LS180_Human1.29841461
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.29712782
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26113728
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.23957881
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22982811
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.22982811
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22643129
62SOX2_19829295_ChIP-Seq_ESCs_Human1.22455761
63NANOG_19829295_ChIP-Seq_ESCs_Human1.22455761
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.22450216
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22075701
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21663254
67TCF4_22108803_ChIP-Seq_LS180_Human1.19743410
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19403527
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.17791573
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17518917
71P53_22387025_ChIP-Seq_ESCs_Mouse1.15895631
72RUNX2_22187159_ChIP-Seq_PCA_Human1.14031093
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13828220
74TP53_22573176_ChIP-Seq_HFKS_Human1.13021548
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12494424
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12431753
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.11767230
78AR_20517297_ChIP-Seq_VCAP_Human1.11521541
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10542758
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10348995
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09778207
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09579428
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.09044242
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.08633660
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07236708
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.06943417
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06156342
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05286351
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.04289632
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03497010
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.03320002
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03292525
93P300_18555785_Chip-Seq_ESCs_Mouse1.02991155
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.01022742
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.01013437
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.00925241
97AHR_22903824_ChIP-Seq_MCF-7_Human1.00597062
98CJUN_26792858_Chip-Seq_BT549_Human0.98173803
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98055389
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97513444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.25652165
2MP0003195_calcinosis4.19766904
3MP0002638_abnormal_pupillary_reflex4.00127330
4MP0008877_abnormal_DNA_methylation3.45585058
5MP0005187_abnormal_penis_morphology3.17073824
6MP0009046_muscle_twitch2.76689061
7MP0002837_dystrophic_cardiac_calcinosis2.71758204
8MP0006072_abnormal_retinal_apoptosis2.69526929
9MP0005670_abnormal_white_adipose2.67227363
10MP0002909_abnormal_adrenal_gland2.59303431
11MP0009780_abnormal_chondrocyte_physiolo2.51575106
12MP0005645_abnormal_hypothalamus_physiol2.42996648
13MP0003136_yellow_coat_color2.36437907
14MP0005379_endocrine/exocrine_gland_phen1.99694497
15MP0005253_abnormal_eye_physiology1.91928365
16MP0002876_abnormal_thyroid_physiology1.90129300
17MP0002163_abnormal_gland_morphology1.82431877
18MP0001944_abnormal_pancreas_morphology1.75796642
19MP0003122_maternal_imprinting1.70968765
20MP0006276_abnormal_autonomic_nervous1.69163882
21MP0010329_abnormal_lipoprotein_level1.69048136
22MP0005551_abnormal_eye_electrophysiolog1.66266502
23MP0002254_reproductive_system_inflammat1.65923231
24MP0003121_genomic_imprinting1.65460978
25MP0001501_abnormal_sleep_pattern1.58203829
26MP0001986_abnormal_taste_sensitivity1.57285081
27MP0001502_abnormal_circadian_rhythm1.56748700
28MP0002693_abnormal_pancreas_physiology1.52385763
29MP0009745_abnormal_behavioral_response1.51692787
30MP0000569_abnormal_digit_pigmentation1.49953219
31MP0005646_abnormal_pituitary_gland1.49519052
32MP0005085_abnormal_gallbladder_physiolo1.47201737
33MP0010234_abnormal_vibrissa_follicle1.42878355
34MP0000427_abnormal_hair_cycle1.42352586
35MP0002090_abnormal_vision1.37286025
36MP0005365_abnormal_bile_salt1.37191001
37MP0006292_abnormal_olfactory_placode1.34609904
38MP0001970_abnormal_pain_threshold1.33687917
39MP0001984_abnormal_olfaction1.32902080
40MP0004019_abnormal_vitamin_homeostasis1.32816773
41MP0002736_abnormal_nociception_after1.32758159
42MP0002139_abnormal_hepatobiliary_system1.27935151
43MP0010386_abnormal_urinary_bladder1.24683484
44MP0000372_irregular_coat_pigmentation1.22112408
45MP0003890_abnormal_embryonic-extraembry1.19772403
46MP0001905_abnormal_dopamine_level1.17603452
47MP0008872_abnormal_physiological_respon1.16317209
48MP0005084_abnormal_gallbladder_morpholo1.14982679
49MP0002078_abnormal_glucose_homeostasis1.13796293
50MP0001968_abnormal_touch/_nociception1.12942168
51MP0005535_abnormal_body_temperature1.09465742
52MP0004215_abnormal_myocardial_fiber1.07433318
53MP0003123_paternal_imprinting1.07323599
54MP0000013_abnormal_adipose_tissue1.06936553
55MP0001485_abnormal_pinna_reflex1.04672216
56MP0003172_abnormal_lysosome_physiology1.04335060
57MP0002733_abnormal_thermal_nociception1.03529804
58MP0001299_abnormal_eye_distance/1.03094404
59MP0003252_abnormal_bile_duct1.02722851
60MP0002734_abnormal_mechanical_nocicepti1.02350147
61MP0008995_early_reproductive_senescence1.02136848
62MP0004085_abnormal_heartbeat1.02112359
63MP0000538_abnormal_urinary_bladder1.02086507
64MP0002572_abnormal_emotion/affect_behav1.01203166
65MP0002064_seizures1.00092633
66MP0003953_abnormal_hormone_level0.99262038
67MP0002229_neurodegeneration0.96112466
68MP0000516_abnormal_urinary_system0.96064042
69MP0005367_renal/urinary_system_phenotyp0.96064042
70MP0005332_abnormal_amino_acid0.96035558
71MP0003718_maternal_effect0.94876716
72MP0004043_abnormal_pH_regulation0.93103587
73MP0001661_extended_life_span0.92264573
74MP0000647_abnormal_sebaceous_gland0.91779059
75MP0001756_abnormal_urination0.90402081
76MP0002102_abnormal_ear_morphology0.90005851
77MP0000631_abnormal_neuroendocrine_gland0.89791640
78MP0002272_abnormal_nervous_system0.89338854
79MP0005174_abnormal_tail_pigmentation0.87669345
80MP0010352_gastrointestinal_tract_polyps0.86348424
81MP0008775_abnormal_heart_ventricle0.85994095
82MP0003880_abnormal_central_pattern0.85843296
83MP0003868_abnormal_feces_composition0.84873646
84MP0000639_abnormal_adrenal_gland0.84654542
85MP0003045_fibrosis0.84314823
86MP0002557_abnormal_social/conspecific_i0.84260485
87MP0002009_preneoplasia0.84193335
88MP0002735_abnormal_chemical_nociception0.82196409
89MP0010678_abnormal_skin_adnexa0.82129423
90MP0002160_abnormal_reproductive_system0.81942754
91MP0002928_abnormal_bile_duct0.81885027
92MP0002168_other_aberrant_phenotype0.81398423
93MP0005195_abnormal_posterior_eye0.80470387
94MP0003633_abnormal_nervous_system0.79974521
95MP0005395_other_phenotype0.78591361
96MP0005220_abnormal_exocrine_pancreas0.78575915
97MP0005448_abnormal_energy_balance0.77621561
98MP0003300_gastrointestinal_ulcer0.77055424
99MP0005408_hypopigmentation0.76898131
100MP0005636_abnormal_mineral_homeostasis0.76159992

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)4.01806179
2Diastasis recti (HP:0001540)3.95377666
3Hypothermia (HP:0002045)3.90618113
4Hyperventilation (HP:0002883)3.78581152
5Intestinal atresia (HP:0011100)3.46099453
6Limb dystonia (HP:0002451)3.42465093
7Medial flaring of the eyebrow (HP:0010747)3.38905475
8Decreased central vision (HP:0007663)3.36038032
9Bony spicule pigmentary retinopathy (HP:0007737)3.21791346
10Chronic hepatic failure (HP:0100626)3.16566301
11Large for gestational age (HP:0001520)3.04691275
12Distal arthrogryposis (HP:0005684)2.91141653
13Nephronophthisis (HP:0000090)2.90745097
14Hemiparesis (HP:0001269)2.88737094
15Congenital primary aphakia (HP:0007707)2.78388200
16Gait imbalance (HP:0002141)2.78004419
17Molar tooth sign on MRI (HP:0002419)2.76999685
18Abnormality of midbrain morphology (HP:0002418)2.76999685
19Cone-rod dystrophy (HP:0000548)2.73415134
20Generalized myoclonic seizures (HP:0002123)2.72975023
21Mesangial abnormality (HP:0001966)2.70087777
22Nephrogenic diabetes insipidus (HP:0009806)2.69060985
23Pancreatic fibrosis (HP:0100732)2.65811199
24Hypomagnesemia (HP:0002917)2.63960832
25Attenuation of retinal blood vessels (HP:0007843)2.57855198
26Absent/shortened dynein arms (HP:0200106)2.55169613
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.55169613
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53105266
29Abnormality of the renal cortex (HP:0011035)2.53077034
30Abolished electroretinogram (ERG) (HP:0000550)2.51864959
31Abnormality of the renal medulla (HP:0100957)2.47820305
32Progressive macrocephaly (HP:0004481)2.41480873
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.38132432
34Hypoplasia of the fovea (HP:0007750)2.38132432
35Microretrognathia (HP:0000308)2.36786531
36Neoplasm of the adrenal cortex (HP:0100641)2.36584674
37Renal cortical cysts (HP:0000803)2.34868295
38Pancreatic cysts (HP:0001737)2.28624925
39Abnormality of vitamin B metabolism (HP:0004340)2.28348565
40Bifid tongue (HP:0010297)2.28100846
41Difficulty running (HP:0009046)2.27269615
42Tubulointerstitial nephritis (HP:0001970)2.26224953
43Aqueductal stenosis (HP:0002410)2.26110091
44Genital tract atresia (HP:0001827)2.25720743
45Polydipsia (HP:0001959)2.21770005
46Abnormal drinking behavior (HP:0030082)2.21770005
47Follicular hyperkeratosis (HP:0007502)2.21580130
48Ketoacidosis (HP:0001993)2.19306826
49True hermaphroditism (HP:0010459)2.15719916
50Decreased circulating renin level (HP:0003351)2.14244576
51Methylmalonic acidemia (HP:0002912)2.11228301
52Vaginal atresia (HP:0000148)2.11067690
53Abnormality of the fovea (HP:0000493)2.10830518
54Abnormality of magnesium homeostasis (HP:0004921)2.09529431
55Acute necrotizing encephalopathy (HP:0006965)2.07864300
56Hyperinsulinemic hypoglycemia (HP:0000825)2.06722046
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.06419196
58Abnormal respiratory motile cilium morphology (HP:0005938)2.05050756
59Abnormal respiratory epithelium morphology (HP:0012253)2.05050756
60Limb hypertonia (HP:0002509)2.03402707
61Muscular hypotonia of the trunk (HP:0008936)2.00020223
62Acute encephalopathy (HP:0006846)1.99716047
63Type II lissencephaly (HP:0007260)1.98297127
64Pendular nystagmus (HP:0012043)1.98109508
65Abnormal glycosylation (HP:0012345)1.97944618
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97944618
67Abnormal protein N-linked glycosylation (HP:0012347)1.97944618
68Abnormal protein glycosylation (HP:0012346)1.97944618
69Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97772674
70Increased corneal curvature (HP:0100692)1.96421460
71Keratoconus (HP:0000563)1.96421460
72Enlarged penis (HP:0000040)1.95980337
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95514136
74Hyperglycemia (HP:0003074)1.94939559
75Tubular atrophy (HP:0000092)1.93013008
76Neoplasm of the adrenal gland (HP:0100631)1.93004900
77Concave nail (HP:0001598)1.91715598
78Poor coordination (HP:0002370)1.90963041
79Agitation (HP:0000713)1.90260357
80Focal seizures (HP:0007359)1.89927618
81Abnormality of vitamin metabolism (HP:0100508)1.88477279
82Decreased testicular size (HP:0008734)1.87291423
83Proximal tubulopathy (HP:0000114)1.85790874
84Nephrotic syndrome (HP:0000100)1.84817422
85Abnormal ciliary motility (HP:0012262)1.84478561
86Abnormality of renin-angiotensin system (HP:0000847)1.83860820
87Congenital stationary night blindness (HP:0007642)1.83802633
88Lissencephaly (HP:0001339)1.82796657
89Metaphyseal dysplasia (HP:0100255)1.81605576
90Hypoglycemic seizures (HP:0002173)1.81535872
91Hamartoma of the eye (HP:0010568)1.81122402
92Increased CSF lactate (HP:0002490)1.80906016
93Oculomotor apraxia (HP:0000657)1.80307510
94Abnormality of the pancreatic islet cells (HP:0006476)1.79831117
95Abnormality of endocrine pancreas physiology (HP:0012093)1.79831117
96Gastrointestinal atresia (HP:0002589)1.74151187
97Increased circulating renin level (HP:0000848)1.72444950
98Hypolipoproteinemia (HP:0010981)1.72397625
99EEG with generalized epileptiform discharges (HP:0011198)1.70849340
100Hypoalphalipoproteinemia (HP:0003233)1.70571563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.26503450
2FGFR22.93012318
3TRIM282.72648994
4WNK32.70785581
5CSNK1G12.46066390
6CSNK1G32.40237044
7CLK12.39765055
8ACVR1B2.37310393
9PIK3CG2.33658269
10MST42.30134199
11CSNK1G22.26530468
12PHKG22.04154181
13PHKG12.04154181
14MAP3K122.01946225
15CASK2.00036455
16NTRK31.79428584
17FER1.78779405
18EPHA31.66972396
19NUAK11.65183558
20PDK21.64878069
21GRK11.63148365
22ADRBK21.57374011
23INSRR1.56735826
24EIF2AK31.53135616
25OXSR11.52858955
26NLK1.50050996
27CDK121.48534028
28AKT31.46617479
29PAK31.45176835
30ERN11.36086114
31PLK21.35271376
32FGFR31.33720053
33STK391.25732645
34STK31.25379517
35MAP3K21.16644258
36PRKCE1.14229485
37SGK21.13651905
38STK38L1.12446194
39PRKCI1.10639828
40IRAK11.02441979
41BMPR1B0.99389607
42MAP4K20.94230247
43TLK10.93416770
44TAOK30.88682574
45CSNK1A10.87837021
46TNIK0.82372556
47MKNK20.78438413
48NME10.77869846
49PINK10.76295635
50MAPK130.75906946
51MAP2K60.74799941
52PRKCG0.74776120
53TRPM70.74128623
54WNK40.69885919
55EIF2AK10.68993781
56MAP3K40.68968424
57BMPR20.65774839
58JAK10.64475928
59FGFR10.63427867
60PIK3CA0.62024482
61CSNK1A1L0.61673959
62STK240.61193863
63MYLK0.59404303
64FLT30.57983578
65SGK2230.57655532
66SGK4940.57655532
67DYRK20.56268692
68CSNK1E0.55965856
69PLK30.54861168
70SGK30.53418063
71STK160.51964610
72MAP2K70.51844284
73ERBB30.51495722
74CSNK1D0.47377422
75STK380.46236176
76ADRBK10.45087265
77PRKAA10.45062960
78PTK2B0.44163803
79CDK90.43204707
80EPHA40.42971903
81BRD40.41711007
82ZAK0.41258516
83STK110.40690795
84ROCK10.36950523
85STK40.36911197
86TIE10.36506308
87IKBKB0.36243771
88CDK30.35717726
89MAP2K10.34856882
90MAP3K10.31427627
91DAPK20.30604606
92EPHB10.29049080
93FGFR40.28416359
94PRKG10.27694874
95CAMK2D0.26433272
96HIPK20.25440916
97GSK3A0.25253091
98PRKCA0.23891340
99RPS6KB10.23598866
100PNCK0.23348733

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.15842353
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.88383839
3Nitrogen metabolism_Homo sapiens_hsa009102.61767185
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.55815754
5Sulfur metabolism_Homo sapiens_hsa009202.39233629
6Vitamin B6 metabolism_Homo sapiens_hsa007502.39107441
7Protein export_Homo sapiens_hsa030602.35040734
8Circadian rhythm_Homo sapiens_hsa047102.15460512
9Butanoate metabolism_Homo sapiens_hsa006502.10692616
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04980980
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.00957566
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99216187
13Phototransduction_Homo sapiens_hsa047441.98132317
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78810675
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74066338
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67164388
17Amphetamine addiction_Homo sapiens_hsa050311.53554836
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51572670
19Tryptophan metabolism_Homo sapiens_hsa003801.46805370
20Cocaine addiction_Homo sapiens_hsa050301.46614781
21Ether lipid metabolism_Homo sapiens_hsa005651.38898267
22Fatty acid elongation_Homo sapiens_hsa000621.38406620
23Propanoate metabolism_Homo sapiens_hsa006401.36516914
24Oxidative phosphorylation_Homo sapiens_hsa001901.36159993
25Linoleic acid metabolism_Homo sapiens_hsa005911.29546664
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28432248
27Nicotine addiction_Homo sapiens_hsa050331.26941080
28Collecting duct acid secretion_Homo sapiens_hsa049661.25659056
29Basal transcription factors_Homo sapiens_hsa030221.25148801
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25085621
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24837609
32Insulin secretion_Homo sapiens_hsa049111.23186167
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.21608456
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20142669
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18421158
36Sphingolipid metabolism_Homo sapiens_hsa006001.18411098
37Selenocompound metabolism_Homo sapiens_hsa004501.12936391
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12185682
39Synaptic vesicle cycle_Homo sapiens_hsa047211.08603913
40Peroxisome_Homo sapiens_hsa041461.05393865
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.05123861
42Caffeine metabolism_Homo sapiens_hsa002321.02981619
43Retinol metabolism_Homo sapiens_hsa008301.01894099
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00555840
45Chemical carcinogenesis_Homo sapiens_hsa052040.99443089
46Fat digestion and absorption_Homo sapiens_hsa049750.97321548
47ABC transporters_Homo sapiens_hsa020100.96128200
48Fatty acid metabolism_Homo sapiens_hsa012120.96093826
49N-Glycan biosynthesis_Homo sapiens_hsa005100.93618588
50Serotonergic synapse_Homo sapiens_hsa047260.91474502
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90663727
52Dorso-ventral axis formation_Homo sapiens_hsa043200.89857096
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89092730
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88940002
55Parkinsons disease_Homo sapiens_hsa050120.88663488
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84907621
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84860032
58Fatty acid biosynthesis_Homo sapiens_hsa000610.84186100
59Dopaminergic synapse_Homo sapiens_hsa047280.83938735
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80637474
61Metabolic pathways_Homo sapiens_hsa011000.79685921
62Steroid biosynthesis_Homo sapiens_hsa001000.79242154
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77843577
64Non-homologous end-joining_Homo sapiens_hsa034500.76523233
65Taste transduction_Homo sapiens_hsa047420.75085197
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.74734314
67Vitamin digestion and absorption_Homo sapiens_hsa049770.74201869
68Mineral absorption_Homo sapiens_hsa049780.73901074
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72838426
70Proteasome_Homo sapiens_hsa030500.70151397
71Glutathione metabolism_Homo sapiens_hsa004800.69781262
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68826809
73Folate biosynthesis_Homo sapiens_hsa007900.66261195
74Huntingtons disease_Homo sapiens_hsa050160.64596470
75Other glycan degradation_Homo sapiens_hsa005110.64335385
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63549259
77One carbon pool by folate_Homo sapiens_hsa006700.62784009
78Lysosome_Homo sapiens_hsa041420.62782360
79Arginine and proline metabolism_Homo sapiens_hsa003300.62085017
80beta-Alanine metabolism_Homo sapiens_hsa004100.61916603
81TGF-beta signaling pathway_Homo sapiens_hsa043500.59554629
82Type II diabetes mellitus_Homo sapiens_hsa049300.59419320
83RNA degradation_Homo sapiens_hsa030180.59216797
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53288409
85Circadian entrainment_Homo sapiens_hsa047130.53286560
86Ovarian steroidogenesis_Homo sapiens_hsa049130.52910778
87Glutamatergic synapse_Homo sapiens_hsa047240.52368825
88Complement and coagulation cascades_Homo sapiens_hsa046100.52359334
89Fatty acid degradation_Homo sapiens_hsa000710.49882503
90Calcium signaling pathway_Homo sapiens_hsa040200.48384172
91Cardiac muscle contraction_Homo sapiens_hsa042600.48106832
92Alzheimers disease_Homo sapiens_hsa050100.47419371
93GABAergic synapse_Homo sapiens_hsa047270.46228832
94Histidine metabolism_Homo sapiens_hsa003400.46035879
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44946966
96Arachidonic acid metabolism_Homo sapiens_hsa005900.44735219
97RNA polymerase_Homo sapiens_hsa030200.43659614
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41914359
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41470466
100Arginine biosynthesis_Homo sapiens_hsa002200.39222098

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »