NFE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.27155323
2DNA deamination (GO:0045006)6.00419359
3neutrophil activation involved in immune response (GO:0002283)5.69891646
4viral transcription (GO:0019083)5.59227887
5translational termination (GO:0006415)5.34102155
6definitive hemopoiesis (GO:0060216)5.28643074
7oxygen transport (GO:0015671)5.09087997
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93482134
9translational elongation (GO:0006414)4.74247697
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63984733
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.63984733
12modulation by symbiont of host immune response (GO:0052553)4.63984733
13positive regulation by symbiont of host defense response (GO:0052509)4.63984733
14modulation by symbiont of host defense response (GO:0052031)4.63984733
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63984733
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.63913021
17antigen processing and presentation via MHC class Ib (GO:0002475)4.56632381
18cotranslational protein targeting to membrane (GO:0006613)4.52435596
19protein targeting to ER (GO:0045047)4.49903580
20ribosomal small subunit biogenesis (GO:0042274)4.49058687
21gas transport (GO:0015669)4.43526606
22regulation of mast cell degranulation (GO:0043304)4.36739731
23negative regulation of erythrocyte differentiation (GO:0045647)4.36471199
24response to peptidoglycan (GO:0032494)4.32850614
25protein localization to endoplasmic reticulum (GO:0070972)4.30817863
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.28270480
27negative regulation of cell killing (GO:0031342)4.27594242
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.27594242
29regulation of B cell receptor signaling pathway (GO:0050855)4.25615926
30telomere maintenance via semi-conservative replication (GO:0032201)4.21926576
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20871911
32platelet dense granule organization (GO:0060155)4.19322120
33detection of other organism (GO:0098543)4.18919478
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18130346
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18130346
36detection of bacterium (GO:0016045)4.18057760
37maturation of SSU-rRNA (GO:0030490)4.16868597
38viral life cycle (GO:0019058)4.14199449
39megakaryocyte development (GO:0035855)4.12984281
40regulation of mast cell activation involved in immune response (GO:0033006)4.04229479
41response to interferon-beta (GO:0035456)4.01043838
42cellular protein complex disassembly (GO:0043624)3.97708423
43neutrophil activation (GO:0042119)3.92972002
44translational initiation (GO:0006413)3.92243422
45DNA strand elongation involved in DNA replication (GO:0006271)3.90201894
46leukocyte migration involved in inflammatory response (GO:0002523)3.86617782
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.81921654
48DNA strand elongation (GO:0022616)3.79761607
49leukocyte aggregation (GO:0070486)3.78527059
50regulation of gamma-delta T cell differentiation (GO:0045586)3.77399305
51regulation of gamma-delta T cell activation (GO:0046643)3.77119405
52cellular extravasation (GO:0045123)3.75389125
53response to host immune response (GO:0052572)3.71164231
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71164231
55positive regulation of B cell differentiation (GO:0045579)3.68971819
56endosome to pigment granule transport (GO:0043485)3.67013289
57endosome to melanosome transport (GO:0035646)3.67013289
58lymphoid progenitor cell differentiation (GO:0002320)3.66124425
59regulation of leukocyte degranulation (GO:0043300)3.52390788
60microglial cell activation (GO:0001774)3.52301902
61positive regulation of mast cell activation (GO:0033005)3.51136709
62hemoglobin metabolic process (GO:0020027)3.51009476
63leukocyte degranulation (GO:0043299)3.50457559
64regulation of mast cell activation (GO:0033003)3.50043838
65telomere maintenance via recombination (GO:0000722)3.49859885
66granulocyte activation (GO:0036230)3.48875486
67* protein complex disassembly (GO:0043241)3.45718040
68erythrocyte development (GO:0048821)3.43795196
69regulation of platelet aggregation (GO:0090330)3.43110218
70antigen processing and presentation of endogenous antigen (GO:0019883)3.39083391
71response to interferon-alpha (GO:0035455)3.37434230
72B cell receptor signaling pathway (GO:0050853)3.33738561
73detection of external biotic stimulus (GO:0098581)3.33355246
74mature B cell differentiation involved in immune response (GO:0002313)3.31541906
75purine-containing compound salvage (GO:0043101)3.31210359
76nuclear-transcribed mRNA catabolic process (GO:0000956)3.30766240
77negative regulation of lymphocyte mediated immunity (GO:0002707)3.30583423
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.29689634
79response to host (GO:0075136)3.29689634
80response to host defenses (GO:0052200)3.29689634
81myeloid cell activation involved in immune response (GO:0002275)3.28912358
82respiratory burst (GO:0045730)3.26219906
83regulation of erythrocyte differentiation (GO:0045646)3.25884257
84macrophage activation involved in immune response (GO:0002281)3.24107727
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23808001
86* macromolecular complex disassembly (GO:0032984)3.22547786
87erythrocyte maturation (GO:0043249)3.22096222
88positive regulation of mast cell degranulation (GO:0043306)3.21826395
89positive regulation of mast cell activation involved in immune response (GO:0033008)3.21826395
90heme biosynthetic process (GO:0006783)3.21169949
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20564422
92mucosal-associated lymphoid tissue development (GO:0048537)3.19909570
93Peyers patch development (GO:0048541)3.19909570
94response to interleukin-15 (GO:0070672)3.18342392
95DNA replication initiation (GO:0006270)3.18245919
96mRNA catabolic process (GO:0006402)3.17794186
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16965862
98secretory granule organization (GO:0033363)3.15653944
99positive regulation of gamma-delta T cell activation (GO:0046645)3.13552088
100ribosomal large subunit biogenesis (GO:0042273)3.09266594
101regulation of granulocyte differentiation (GO:0030852)3.07946432
102RNA catabolic process (GO:0006401)3.06756754
103neutrophil mediated immunity (GO:0002446)3.04578319
104formation of translation preinitiation complex (GO:0001731)3.04382010
105negative regulation of leukocyte mediated immunity (GO:0002704)3.04379255
106defense response to protozoan (GO:0042832)3.02970767
107negative regulation of interleukin-12 production (GO:0032695)3.00710627
108respiratory chain complex IV assembly (GO:0008535)3.00508575
109mitotic recombination (GO:0006312)3.00451628
110telomere maintenance via telomere lengthening (GO:0010833)2.99953515
111protoporphyrinogen IX metabolic process (GO:0046501)2.98058132
112embryonic hemopoiesis (GO:0035162)2.97219020
113regulation of regulated secretory pathway (GO:1903305)2.96968184
114IMP metabolic process (GO:0046040)2.96760403
115thrombin receptor signaling pathway (GO:0070493)2.95513279
116pseudouridine synthesis (GO:0001522)2.94963373
117negative regulation of viral entry into host cell (GO:0046597)2.93493676
118protein targeting to membrane (GO:0006612)2.92517881
119T cell homeostasis (GO:0043029)2.91024957
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90983151
121IMP biosynthetic process (GO:0006188)2.90951203
122ribonucleoprotein complex biogenesis (GO:0022613)2.90824477
123autophagic vacuole fusion (GO:0000046)2.90450073
124detection of biotic stimulus (GO:0009595)2.90298055
125negative regulation of T cell mediated immunity (GO:0002710)2.89580493
126response to protozoan (GO:0001562)2.88081709
127granulocyte differentiation (GO:0030851)2.87696462
128positive thymic T cell selection (GO:0045059)2.86108990
129regulation of B cell apoptotic process (GO:0002902)2.85216835
130regulation of B cell differentiation (GO:0045577)2.83762597
131macrophage activation (GO:0042116)2.81514601
132tetrapyrrole biosynthetic process (GO:0033014)2.80451603
133viral mRNA export from host cell nucleus (GO:0046784)2.80357413
134positive regulation of megakaryocyte differentiation (GO:0045654)2.79932645
135DNA unwinding involved in DNA replication (GO:0006268)2.79584097
136translation (GO:0006412)2.79388224
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.79293926
138mast cell activation (GO:0045576)2.76178843
139positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74794703
140positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72589308
141response to muramyl dipeptide (GO:0032495)2.70160258
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69487871
143lymph node development (GO:0048535)2.68767419
144myeloid cell development (GO:0061515)2.67809815
145regulation of interferon-beta biosynthetic process (GO:0045357)2.67800394
146protoporphyrinogen IX biosynthetic process (GO:0006782)2.67715520
147immunoglobulin mediated immune response (GO:0016064)2.67613667
148daunorubicin metabolic process (GO:0044597)2.67210669
149polyketide metabolic process (GO:0030638)2.67210669
150doxorubicin metabolic process (GO:0044598)2.67210669
151L-fucose metabolic process (GO:0042354)2.66916434
152L-fucose catabolic process (GO:0042355)2.66916434
153fucose catabolic process (GO:0019317)2.66916434
154negative thymic T cell selection (GO:0045060)2.66886978
155negative regulation of B cell apoptotic process (GO:0002903)2.66883513
156platelet formation (GO:0030220)2.66769199
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65185865
158iron-sulfur cluster assembly (GO:0016226)2.62105165
159metallo-sulfur cluster assembly (GO:0031163)2.62105165
160mitochondrial DNA replication (GO:0006264)2.60065432
1613-UTR-mediated mRNA stabilization (GO:0070935)2.58952876
162rRNA processing (GO:0006364)2.57745073
163positive regulation of granulocyte differentiation (GO:0030854)2.55488089
164porphyrin-containing compound biosynthetic process (GO:0006779)2.55332468
165macrophage differentiation (GO:0030225)2.54868239
166necroptotic process (GO:0070266)2.52134609
167B cell mediated immunity (GO:0019724)2.51950925
168mature B cell differentiation (GO:0002335)2.51220492
169rRNA metabolic process (GO:0016072)2.49908048
170tRNA methylation (GO:0030488)2.49700489
171negative regulation of phagocytosis (GO:0050765)2.49145849
172cellular response to thyroid hormone stimulus (GO:0097067)2.46708615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.21731500
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96705235
3* SCL_19346495_ChIP-Seq_HPC-7_Human3.61308065
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.19832829
5* GATA1_19941826_ChIP-Seq_K562_Human3.04123645
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.97335639
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91424275
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.82907728
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80699669
10* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.77082347
11FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.56091091
12SPI1_23127762_ChIP-Seq_K562_Human2.45294853
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41237460
14VDR_21846776_ChIP-Seq_THP-1_Human2.41155114
15GATA1_22025678_ChIP-Seq_K562_Human2.40289671
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.34488273
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33552594
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32841480
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32180683
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24311675
21MYC_22102868_ChIP-Seq_BL_Human2.23194507
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19341370
23ERG_20887958_ChIP-Seq_HPC-7_Mouse2.15154837
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14907330
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.13263388
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10994575
27SPI1_23547873_ChIP-Seq_NB4_Human2.05112742
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.04815636
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04509158
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04370929
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03838380
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.01886597
33* GATA2_19941826_ChIP-Seq_K562_Human1.99025583
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.97731576
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97415626
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.93982098
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91846817
38VDR_23849224_ChIP-Seq_CD4+_Human1.91169638
39* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.86933600
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84954680
41* NCOR1_26117541_ChIP-Seq_K562_Human1.82678122
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82066765
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81526251
44FOXP3_21729870_ChIP-Seq_TREG_Human1.80018603
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79808751
46* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77373780
47RUNX_20019798_ChIP-Seq_JUKART_Human1.71580522
48* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70746874
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70372114
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70179152
51* RUNX1_22412390_ChIP-Seq_EML_Mouse1.70118776
52XRN2_22483619_ChIP-Seq_HELA_Human1.68941173
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68899121
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.66511551
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64586564
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.64291939
57* VDR_24763502_ChIP-Seq_THP-1_Human1.60111476
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57818420
59CIITA_25753668_ChIP-Seq_RAJI_Human1.55805915
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53184776
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52195135
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49752688
63MAF_26560356_Chip-Seq_TH1_Human1.49251344
64GABP_19822575_ChIP-Seq_HepG2_Human1.47272601
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.46619787
66BCL6_27268052_Chip-Seq_Bcells_Human1.46093176
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44646017
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.44370846
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.44023471
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43991276
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43958692
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43107008
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.42660159
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42151261
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42075229
76MYB_26560356_Chip-Seq_TH2_Human1.39457254
77* GATA3_27048872_Chip-Seq_THYMUS_Human1.39211718
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.38499882
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37796597
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36577797
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36532897
82DCP1A_22483619_ChIP-Seq_HELA_Human1.34833656
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34722117
84MYB_26560356_Chip-Seq_TH1_Human1.33853881
85* UTX_26944678_Chip-Seq_JUKART_Human1.32694818
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31266909
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30673347
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29794167
89TTF2_22483619_ChIP-Seq_HELA_Human1.29292783
90BCOR_27268052_Chip-Seq_Bcells_Human1.28670125
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.28321474
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28063845
93* KDM2B_26808549_Chip-Seq_DND41_Human1.27668977
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.23229975
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22808897
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22570732
97* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22107639
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21687976
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19830062
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.19118583
101SPI1_20517297_ChIP-Seq_HL60_Human1.18442284
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17070879
103* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16908729
104* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16137746
105* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14603608
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.13917812
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13559262
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12478799
109* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12091891
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11283137
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10521365
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10097821
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09349353
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08216946
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07224631
116GATA3_26560356_Chip-Seq_TH2_Human1.05952007
117MAF_26560356_Chip-Seq_TH2_Human1.05005517
118* LXR_22292898_ChIP-Seq_THP-1_Human1.04397208
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03751315
120* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03567054
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03145400
122* P68_20966046_ChIP-Seq_HELA_Human1.02576464
123ELK1_19687146_ChIP-ChIP_HELA_Human1.02572245
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01284603
125MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99614088
126* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98811831
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.98709081
128* P300_27268052_Chip-Seq_Bcells_Human0.98261332
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97176144
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95551368
131* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95198116
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94967992
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.94660880
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94353535
135CTCF_21964334_Chip-Seq_Bcells_Human0.93475040
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.92981289
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92513165
138* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92490373
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91606104
140TFEB_21752829_ChIP-Seq_HELA_Human0.91386643
141* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91068744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.30992304
2MP0004147_increased_porphyrin_level3.60370787
3MP0003656_abnormal_erythrocyte_physiolo3.17917667
4MP0005174_abnormal_tail_pigmentation3.10133794
5MP0004808_abnormal_hematopoietic_stem3.01408129
6MP0001835_abnormal_antigen_presentation2.94408164
7MP0000685_abnormal_immune_system2.87203783
8MP0005464_abnormal_platelet_physiology2.73730334
9* MP0001545_abnormal_hematopoietic_system2.71317940
10* MP0005397_hematopoietic_system_phenotyp2.71317940
11MP0009785_altered_susceptibility_to2.68502614
12MP0005075_abnormal_melanosome_morpholog2.67514950
13MP0000465_gastrointestinal_hemorrhage2.50305405
14MP0000490_abnormal_crypts_of2.46627214
15MP0005671_abnormal_response_to2.35555771
16MP0009278_abnormal_bone_marrow2.30968060
17MP0002398_abnormal_bone_marrow2.30539673
18MP0003806_abnormal_nucleotide_metabolis2.22727162
19MP0003693_abnormal_embryo_hatching2.22319003
20MP0005083_abnormal_biliary_tract2.18030994
21* MP0005025_abnormal_response_to2.15359125
22MP0010094_abnormal_chromosome_stability2.12864206
23MP0002095_abnormal_skin_pigmentation2.10113222
24MP0008057_abnormal_DNA_replication2.05830823
25MP0003436_decreased_susceptibility_to2.01182242
26MP0003724_increased_susceptibility_to2.00838896
27* MP0000689_abnormal_spleen_morphology2.00216637
28MP0002722_abnormal_immune_system1.92576956
29MP0002420_abnormal_adaptive_immunity1.88902134
30MP0003763_abnormal_thymus_physiology1.88212989
31MP0001800_abnormal_humoral_immune1.87744194
32MP0001819_abnormal_immune_cell1.85876546
33MP0002452_abnormal_antigen_presenting1.83503868
34MP0008058_abnormal_DNA_repair1.82744434
35MP0002429_abnormal_blood_cell1.82096131
36MP0002419_abnormal_innate_immunity1.81091552
37MP0000716_abnormal_immune_system1.80896619
38MP0002723_abnormal_immune_serum1.78800567
39MP0002148_abnormal_hypersensitivity_rea1.78761147
40MP0001853_heart_inflammation1.76436161
41MP0002166_altered_tumor_susceptibility1.75601273
42MP0001986_abnormal_taste_sensitivity1.71897763
43MP0003111_abnormal_nucleus_morphology1.69377866
44MP0003866_abnormal_defecation1.67028422
45MP0005000_abnormal_immune_tolerance1.66729161
46MP0003077_abnormal_cell_cycle1.66036989
47MP0008007_abnormal_cellular_replicative1.65679025
48MP0010155_abnormal_intestine_physiology1.65013654
49MP0009379_abnormal_foot_pigmentation1.59411891
50MP0008260_abnormal_autophagy1.56868660
51MP0009333_abnormal_splenocyte_physiolog1.56259456
52MP0001873_stomach_inflammation1.54189431
53MP0000015_abnormal_ear_pigmentation1.53479199
54MP0004957_abnormal_blastocyst_morpholog1.45722885
55MP0002405_respiratory_system_inflammati1.43047823
56MP0003300_gastrointestinal_ulcer1.39721082
57MP0000703_abnormal_thymus_morphology1.39046804
58MP0006054_spinal_hemorrhage1.38685979
59MP0001790_abnormal_immune_system1.36325973
60MP0005387_immune_system_phenotype1.36325973
61* MP0002019_abnormal_tumor_incidence1.33776902
62MP0005451_abnormal_body_composition1.32932859
63MP0008004_abnormal_stomach_pH1.28125101
64MP0001845_abnormal_inflammatory_respons1.25323912
65MP0002006_tumorigenesis1.23045999
66MP0006036_abnormal_mitochondrial_physio1.20980919
67MP0003943_abnormal_hepatobiliary_system1.20650162
68MP0002132_abnormal_respiratory_system1.18270329
69MP0001851_eye_inflammation1.18085152
70MP0000313_abnormal_cell_death1.17163307
71MP0006292_abnormal_olfactory_placode1.13876130
72MP0003186_abnormal_redox_activity1.12269477
73MP0008469_abnormal_protein_level1.11564006
74MP0003172_abnormal_lysosome_physiology1.07920325
75MP0002877_abnormal_melanocyte_morpholog1.02768419
76MP0000343_altered_response_to1.00442582
77MP0003567_abnormal_fetal_cardiomyocyte0.99791851
78MP0003786_premature_aging0.99448643
79MP0003191_abnormal_cellular_cholesterol0.99128000
80MP0005084_abnormal_gallbladder_morpholo0.98247148
81* MP0009763_increased_sensitivity_to0.96370225
82MP0005058_abnormal_lysosome_morphology0.95488613
83MP0001764_abnormal_homeostasis0.95372577
84MP0003828_pulmonary_edema0.86587369
85MP0003183_abnormal_peptide_metabolism0.84454052
86MP0005636_abnormal_mineral_homeostasis0.81666974
87MP0006035_abnormal_mitochondrial_morpho0.79984909
88MP0000681_abnormal_thyroid_gland0.78040147
89MP0004883_abnormal_blood_vessel0.76297107
90MP0001663_abnormal_digestive_system0.76086481
91MP0000858_altered_metastatic_potential0.75559113
92MP0005310_abnormal_salivary_gland0.75547647
93MP0001188_hyperpigmentation0.75532031
94MP0000477_abnormal_intestine_morphology0.74957626
95MP0008995_early_reproductive_senescence0.73813790
96MP0009764_decreased_sensitivity_to0.73719673
97MP0010307_abnormal_tumor_latency0.71226696
98MP0002075_abnormal_coat/hair_pigmentati0.71031764
99MP0001533_abnormal_skeleton_physiology0.70661467
100MP0003303_peritoneal_inflammation0.69314902
101MP0008874_decreased_physiological_sensi0.67530311
102MP0000598_abnormal_liver_morphology0.67450979
103MP0005164_abnormal_response_to0.66377326
104MP0000350_abnormal_cell_proliferation0.66249011
105MP0005535_abnormal_body_temperature0.65916276
106MP0009765_abnormal_xenobiotic_induced0.65754872
107MP0002933_joint_inflammation0.65656783
108MP0004381_abnormal_hair_follicle0.62696738
109MP0006082_CNS_inflammation0.62674486
110MP0001348_abnormal_lacrimal_gland0.62358391
111MP0004947_skin_inflammation0.61727816
112MP0009931_abnormal_skin_appearance0.60683261
113MP0000609_abnormal_liver_physiology0.60390947
114MP0000371_diluted_coat_color0.59903152
115MP0009697_abnormal_copulation0.59753705
116MP0002277_abnormal_respiratory_mucosa0.59150904
117MP0002009_preneoplasia0.58720438
118MP0003638_abnormal_response/metabolism_0.58633156
119MP0005319_abnormal_enzyme/_coenzyme0.57203023
120MP0008873_increased_physiological_sensi0.57119104
121MP0000372_irregular_coat_pigmentation0.57068682
122MP0000358_abnormal_cell_content/0.56147832
123MP0003075_altered_response_to0.55886607
124MP0005166_decreased_susceptibility_to0.54766502
125MP0009642_abnormal_blood_homeostasis0.53136081
126MP0005410_abnormal_fertilization0.51473015
127MP0005376_homeostasis/metabolism_phenot0.51369437
128MP0005390_skeleton_phenotype0.51368483

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.72872507
2Thrombocytosis (HP:0001894)5.55016171
3Abnormality of cells of the erythroid lineage (HP:0012130)5.54276297
4Abnormal number of erythroid precursors (HP:0012131)5.50042575
5Aplastic anemia (HP:0001915)5.11792455
6Hypochromic microcytic anemia (HP:0004840)5.02544220
7Petechiae (HP:0000967)4.60945532
8Prolonged bleeding time (HP:0003010)4.47587434
9Stomatitis (HP:0010280)4.37458115
10Reticulocytopenia (HP:0001896)4.28179046
11IgM deficiency (HP:0002850)4.18344182
12Chronic otitis media (HP:0000389)3.73078674
13Elevated erythrocyte sedimentation rate (HP:0003565)3.70617629
14Epistaxis (HP:0000421)3.58490400
15Abnormal hemoglobin (HP:0011902)3.56344321
16Poikiloderma (HP:0001029)3.53785903
17Reduced antithrombin III activity (HP:0001976)3.49910776
18Myositis (HP:0100614)3.47086908
19Polycythemia (HP:0001901)3.46092789
20Pallor (HP:0000980)3.41900765
21Type I transferrin isoform profile (HP:0003642)3.32893551
22Hypertensive crisis (HP:0100735)3.24519886
23Reticulocytosis (HP:0001923)3.23451996
24Gastrointestinal infarctions (HP:0005244)3.21956988
25Encephalitis (HP:0002383)3.19622722
26Recurrent abscess formation (HP:0002722)3.16340919
27Increased mean platelet volume (HP:0011877)3.12117362
28Retrobulbar optic neuritis (HP:0100654)3.11913278
29Optic neuritis (HP:0100653)3.11913278
30Recurrent gram-negative bacterial infections (HP:0005420)3.08450507
31Mediastinal lymphadenopathy (HP:0100721)3.07742074
32Abnormality of iron homeostasis (HP:0011031)3.07277295
33Abnormal platelet function (HP:0011869)3.03965858
34Impaired platelet aggregation (HP:0003540)3.03965858
35Type 2 muscle fiber atrophy (HP:0003554)2.96530066
36Abnormality of T cell physiology (HP:0011840)2.96220740
37Poikilocytosis (HP:0004447)2.95305161
38Recurrent cutaneous fungal infections (HP:0011370)2.93722994
39Chronic mucocutaneous candidiasis (HP:0002728)2.93722994
40Muscle fiber atrophy (HP:0100295)2.93551469
41Microcytic anemia (HP:0001935)2.93242062
42Granulocytopenia (HP:0001913)2.92954426
43Episodic fever (HP:0001954)2.89213200
44Increased IgE level (HP:0003212)2.88981735
45Macrocytic anemia (HP:0001972)2.88067195
46Myelodysplasia (HP:0002863)2.83992685
47Acute lymphatic leukemia (HP:0006721)2.82690639
48Agammaglobulinemia (HP:0004432)2.78947806
49Leukocytosis (HP:0001974)2.76116603
50Recurrent bacterial skin infections (HP:0005406)2.75841798
51Abnormality of transition element cation homeostasis (HP:0011030)2.73925098
52Abnormality of the nasal mucosa (HP:0000433)2.73231760
53Abnormal protein glycosylation (HP:0012346)2.71331482
54Abnormal glycosylation (HP:0012345)2.71331482
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71331482
56Abnormal protein N-linked glycosylation (HP:0012347)2.71331482
57Amaurosis fugax (HP:0100576)2.70818011
58Hepatosplenomegaly (HP:0001433)2.65968315
59Acute myeloid leukemia (HP:0004808)2.64544197
60Acanthocytosis (HP:0001927)2.58674104
61Recurrent bronchitis (HP:0002837)2.57831644
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.54144043
63Keratoconjunctivitis sicca (HP:0001097)2.50340102
64Cellulitis (HP:0100658)2.48986267
65Pancytopenia (HP:0001876)2.48751617
66Vasculitis (HP:0002633)2.48378038
67Paralysis (HP:0003470)2.47181596
68Arterial thrombosis (HP:0004420)2.44312674
69Gingival bleeding (HP:0000225)2.43843033
70Panhypogammaglobulinemia (HP:0003139)2.40669319
71Entropion (HP:0000621)2.39050071
72Purpura (HP:0000979)2.38766913
73Increased IgM level (HP:0003496)2.38534225
74Anorexia (HP:0002039)2.37010355
75Nasal polyposis (HP:0100582)2.36464505
76Gingivitis (HP:0000230)2.36086127
77Keratoconjunctivitis (HP:0001096)2.35669265
78Cholelithiasis (HP:0001081)2.34789377
79Hyperthyroidism (HP:0000836)2.34693189
80Osteomyelitis (HP:0002754)2.34322963
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32333150
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32333150
83Cholecystitis (HP:0001082)2.32081005
84Abnormal gallbladder physiology (HP:0012438)2.32081005
85Albinism (HP:0001022)2.30935937
86Spontaneous hematomas (HP:0007420)2.30417121
87Abnormality of the columella (HP:0009929)2.29791575
88Abnormality of reticulocytes (HP:0004312)2.28670556
89Meningitis (HP:0001287)2.27264844
90Recurrent viral infections (HP:0004429)2.25033307
91Autoimmune hemolytic anemia (HP:0001890)2.23883071
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23198778
93Skin rash (HP:0000988)2.22286246
94IgG deficiency (HP:0004315)2.22027041
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20554898
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16794951
97Abnormality of the prostate (HP:0008775)2.16486165
98Colon cancer (HP:0003003)2.16256393
99Lymphoma (HP:0002665)2.15761732
100Gastrointestinal inflammation (HP:0004386)2.15369683
101Acute hepatic failure (HP:0006554)2.15070077
102Recurrent fungal infections (HP:0002841)2.14061754
103Aplasia/Hypoplasia of the thymus (HP:0010515)2.13434014
104Pustule (HP:0200039)2.12620598
105Erythema (HP:0010783)2.11013917
106Abnormality of macrophages (HP:0004311)2.10823436
107Seborrheic dermatitis (HP:0001051)2.10379916
108Hepatocellular necrosis (HP:0001404)2.09472741
109Microretrognathia (HP:0000308)2.08826782
110Basal cell carcinoma (HP:0002671)2.08510759
111Abnormality of DNA repair (HP:0003254)2.07009481
112Ileus (HP:0002595)2.06819506
113Hypergammaglobulinemia (HP:0010702)2.05514892
114Bruising susceptibility (HP:0000978)2.04962588
115Increased serum ferritin (HP:0003281)2.04198782
116Exertional dyspnea (HP:0002875)2.03300920
117Abnormal gallbladder morphology (HP:0012437)2.02298655
118Inflammation of the large intestine (HP:0002037)2.01338069
119Abnormality of T cells (HP:0002843)2.01104242
120Thrombophlebitis (HP:0004418)2.00992108
121Severe visual impairment (HP:0001141)2.00590317
122Sepsis (HP:0100806)2.00186394
123Pulmonary embolism (HP:0002204)1.99394769
124Hyperbilirubinemia (HP:0002904)1.99379260
125Recurrent skin infections (HP:0001581)1.98484765
126Neutropenia (HP:0001875)1.98215490
127Vertigo (HP:0002321)1.97482681
128Pulmonary infiltrates (HP:0002113)1.96739988
12911 pairs of ribs (HP:0000878)1.94673024
130Hemoptysis (HP:0002105)1.94565351
131Chest pain (HP:0100749)1.93131548
132Gastrointestinal stroma tumor (HP:0100723)1.92727358
133Hypochromic anemia (HP:0001931)1.91225752
134Skin ulcer (HP:0200042)1.90146184
135Colitis (HP:0002583)1.88299187
136Abnormal platelet volume (HP:0011876)1.87999937
137Birth length less than 3rd percentile (HP:0003561)1.87214368
138Hepatic necrosis (HP:0002605)1.87213228
139Eczematoid dermatitis (HP:0000976)1.86954276
140Asplenia (HP:0001746)1.86050688
1413-Methylglutaconic aciduria (HP:0003535)1.85048198
142Interstitial pulmonary disease (HP:0006530)1.82499336
143Menorrhagia (HP:0000132)1.82101969
144Abnormality of B cell number (HP:0010975)1.81728560
145B lymphocytopenia (HP:0010976)1.81728560
146Bone marrow hypocellularity (HP:0005528)1.81033901
147Cutaneous photosensitivity (HP:0000992)1.80955789
148Fatigue (HP:0012378)1.80357352
149Orchitis (HP:0100796)1.79834568
150Lymphopenia (HP:0001888)1.79117706
151Hypoproteinemia (HP:0003075)1.79071888
152Obstructive lung disease (HP:0006536)1.78206920
153Chronic obstructive pulmonary disease (HP:0006510)1.78206920
154Urticaria (HP:0001025)1.75988685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.21097030
2STK163.14852618
3FLT33.02953518
4TNIK2.78306581
5NME22.70149808
6WEE12.55485832
7EEF2K2.41506599
8TGFBR12.40248448
9MAP4K12.39782192
10CDK192.32868135
11BTK2.26418475
12PIM22.19434005
13TEC2.18166144
14MATK2.12382357
15ACVR1B2.12207023
16MAP2K32.04979793
17MUSK1.89084853
18TESK21.79957382
19PRPF4B1.65659834
20RPS6KB21.64703537
21IRAK41.64328711
22CSF1R1.59859225
23TGFBR21.58249243
24DYRK31.58099632
25TAOK21.57437421
26TIE11.55873409
27TAOK11.55713258
28BRSK21.55669480
29CSK1.54007171
30EIF2AK11.52957684
31MAP3K121.52120429
32MAP3K11.51827442
33MAP3K61.46748175
34VRK11.43133944
35JAK31.41092335
36ZAP701.35549427
37JAK21.31262854
38MAP3K111.30004467
39BCKDK1.28995727
40MAP3K31.28172003
41SYK1.27355237
42BMX1.22608542
43TBK11.18253194
44SCYL21.17150835
45TAOK31.17127223
46FES1.16520408
47MAPKAPK51.16421626
48ITK1.15826043
49PIM11.15243748
50VRK21.10912029
51CDC71.10849200
52BMPR21.08003012
53MAPKAPK31.07582270
54CDK71.05900223
55FGR1.04142972
56NEK21.02681548
57DAPK11.02372681
58BLK1.01947687
59PIK3CG1.01707638
60MARK31.01079764
61CCNB11.00278610
62KDR1.00244458
63LYN1.00117312
64RAF10.97218480
65IKBKE0.96768174
66BUB10.96054570
67PTK2B0.94489969
68CDK80.93313416
69MKNK10.92902546
70IKBKB0.92337752
71TXK0.91119576
72NUAK10.90019468
73TLK10.88586760
74PKN20.88400557
75EPHB10.88110263
76LRRK20.85543276
77ATR0.83370247
78MAP2K60.81370171
79CAMKK20.79380385
80NLK0.78874843
81LCK0.75720452
82MAPK110.75451883
83MAP3K50.73013879
84SMG10.72734008
85ERN10.71678653
86BRSK10.71134826
87PASK0.70877136
88EIF2AK30.70026741
89PRKCQ0.69246528
90CDK40.69171819
91TNK20.68775755
92PRKG20.68369188
93TYK20.67247936
94MAPK120.67047411
95KSR20.66937455
96TRPM70.66481429
97ADRBK20.63786714
98RPS6KA60.61749396
99RPS6KA40.61225177
100RPS6KL10.58365249
101RPS6KC10.58365249
102GRK60.57153353
103MAPK40.56551702
104YES10.56057252
105PDK10.55575652
106PAK40.54992828
107MAP2K40.54874510
108CAMK10.53705471
109MAP3K70.53313000
110MAP3K140.53251466
111CLK10.53183120
112DAPK20.53158806
113STK100.52857897
114MARK20.52008472
115STK40.51905347
116IRAK30.51691288
117GRK50.51443371
118JAK10.50538536
119AURKB0.50374439
120PTK60.50042423
121SRPK10.49660569
122DYRK1B0.49162157
123HCK0.45203348
124FYN0.45150740
125HIPK20.45069519
126RPS6KA50.44177056
127ILK0.43948657
128MYLK0.43622568
129PDPK10.42623341
130MKNK20.41365146
131RIPK40.41119987
132MAP2K20.39113015
133MAP3K80.39072458
134MAPK30.37906875
135IRAK10.37167316
136PRKCD0.36809988
137PLK10.36584105
138PRKD20.35918104
139MAP3K130.34646466
140RET0.34630722
141CDK60.34369139
142PINK10.34169508
143ARAF0.33167737
144PAK10.30107001
145MAPKAPK20.29719282
146ADRBK10.28734499

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99919968
2Ribosome_Homo sapiens_hsa030104.89095319
3Mismatch repair_Homo sapiens_hsa034303.74973626
4Base excision repair_Homo sapiens_hsa034103.14698131
5Homologous recombination_Homo sapiens_hsa034402.48875206
6Staphylococcus aureus infection_Homo sapiens_hsa051502.41628486
7Nucleotide excision repair_Homo sapiens_hsa034202.36484668
8Graft-versus-host disease_Homo sapiens_hsa053322.20535363
9Spliceosome_Homo sapiens_hsa030402.19391247
10Pyrimidine metabolism_Homo sapiens_hsa002402.17845057
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08981261
12Autoimmune thyroid disease_Homo sapiens_hsa053202.07649293
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.03344657
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01609538
15RNA polymerase_Homo sapiens_hsa030201.92329915
16Sulfur relay system_Homo sapiens_hsa041221.88916449
17Primary immunodeficiency_Homo sapiens_hsa053401.80354628
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72013869
19African trypanosomiasis_Homo sapiens_hsa051431.62984043
20Cell cycle_Homo sapiens_hsa041101.60213074
21Type I diabetes mellitus_Homo sapiens_hsa049401.59787604
22Proteasome_Homo sapiens_hsa030501.58128258
23Fanconi anemia pathway_Homo sapiens_hsa034601.51780377
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51081310
25Leishmaniasis_Homo sapiens_hsa051401.48089326
26Hematopoietic cell lineage_Homo sapiens_hsa046401.45900598
27Herpes simplex infection_Homo sapiens_hsa051681.42923307
28Non-homologous end-joining_Homo sapiens_hsa034501.40223880
29RNA degradation_Homo sapiens_hsa030181.36086241
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35268344
31Folate biosynthesis_Homo sapiens_hsa007901.31926020
32B cell receptor signaling pathway_Homo sapiens_hsa046621.28771327
33RNA transport_Homo sapiens_hsa030131.28278566
34N-Glycan biosynthesis_Homo sapiens_hsa005101.28008146
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25589218
36Other glycan degradation_Homo sapiens_hsa005111.25322017
37Chemokine signaling pathway_Homo sapiens_hsa040621.24747575
38Measles_Homo sapiens_hsa051621.24224046
39Pentose phosphate pathway_Homo sapiens_hsa000301.23675100
40Acute myeloid leukemia_Homo sapiens_hsa052211.20124918
41Systemic lupus erythematosus_Homo sapiens_hsa053221.17828474
42Purine metabolism_Homo sapiens_hsa002301.17298587
43Antigen processing and presentation_Homo sapiens_hsa046121.12469552
44p53 signaling pathway_Homo sapiens_hsa041151.11835286
45Viral myocarditis_Homo sapiens_hsa054161.11789893
46Regulation of autophagy_Homo sapiens_hsa041401.11341411
47Pancreatic cancer_Homo sapiens_hsa052121.10869157
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08457378
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.07756953
50Phagosome_Homo sapiens_hsa041451.06403647
51T cell receptor signaling pathway_Homo sapiens_hsa046601.04136894
52Platelet activation_Homo sapiens_hsa046111.03683520
53One carbon pool by folate_Homo sapiens_hsa006701.03588016
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.03122326
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02912581
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.02342961
57Thyroid cancer_Homo sapiens_hsa052160.99445371
58Basal transcription factors_Homo sapiens_hsa030220.99430177
59Shigellosis_Homo sapiens_hsa051310.98251518
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97160149
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93089269
62Legionellosis_Homo sapiens_hsa051340.92010198
63Protein export_Homo sapiens_hsa030600.90216168
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90055903
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87790797
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.87128593
67VEGF signaling pathway_Homo sapiens_hsa043700.79356005
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79050954
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78567389
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77670620
71Galactose metabolism_Homo sapiens_hsa000520.76675606
72Caffeine metabolism_Homo sapiens_hsa002320.73741082
73Hepatitis B_Homo sapiens_hsa051610.73480537
74Rheumatoid arthritis_Homo sapiens_hsa053230.73284717
75Epstein-Barr virus infection_Homo sapiens_hsa051690.73160766
76Hepatitis C_Homo sapiens_hsa051600.71209089
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70698652
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69302430
79TNF signaling pathway_Homo sapiens_hsa046680.68609354
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67167018
81Malaria_Homo sapiens_hsa051440.66066306
82Viral carcinogenesis_Homo sapiens_hsa052030.65574797
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.65085030
84Influenza A_Homo sapiens_hsa051640.64059382
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63416684
86Pertussis_Homo sapiens_hsa051330.63219238
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.63145073
88Apoptosis_Homo sapiens_hsa042100.62771454
89Asthma_Homo sapiens_hsa053100.62761965
90Osteoclast differentiation_Homo sapiens_hsa043800.60754998
91Endocytosis_Homo sapiens_hsa041440.59605675
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59587109
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.59245526
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57566777
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54710574
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52766073
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52050861
98Chronic myeloid leukemia_Homo sapiens_hsa052200.51481481
99Olfactory transduction_Homo sapiens_hsa047400.51059118
100Inositol phosphate metabolism_Homo sapiens_hsa005620.50113539
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47628922
102Prolactin signaling pathway_Homo sapiens_hsa049170.47159691
103Selenocompound metabolism_Homo sapiens_hsa004500.46938098
104Alcoholism_Homo sapiens_hsa050340.46814648
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45889979
106Collecting duct acid secretion_Homo sapiens_hsa049660.44587522
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43834081
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.42521883
109mTOR signaling pathway_Homo sapiens_hsa041500.40676513
110Non-small cell lung cancer_Homo sapiens_hsa052230.40381485
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.40200301
112Glutathione metabolism_Homo sapiens_hsa004800.40105435
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39534612
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39467618
115Allograft rejection_Homo sapiens_hsa053300.38125331
116Toxoplasmosis_Homo sapiens_hsa051450.38081060
117mRNA surveillance pathway_Homo sapiens_hsa030150.37993397
118ABC transporters_Homo sapiens_hsa020100.37848759
119Fructose and mannose metabolism_Homo sapiens_hsa000510.37649527
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37215767
121HIF-1 signaling pathway_Homo sapiens_hsa040660.36898130
122Tuberculosis_Homo sapiens_hsa051520.36767498
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36536042
124Choline metabolism in cancer_Homo sapiens_hsa052310.35946940
125Lysosome_Homo sapiens_hsa041420.35303989
126Arachidonic acid metabolism_Homo sapiens_hsa005900.33567372
127HTLV-I infection_Homo sapiens_hsa051660.33559312
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.32743613
129Salmonella infection_Homo sapiens_hsa051320.32479108
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30917857
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30531700
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30315778
133Biosynthesis of amino acids_Homo sapiens_hsa012300.30250125
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.30230496
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.28087113
136Amoebiasis_Homo sapiens_hsa051460.27218157
137Nitrogen metabolism_Homo sapiens_hsa009100.26163416
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.24925998

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