NFASC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.72730696
2central nervous system myelination (GO:0022010)7.72730696
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.15308361
4fatty acid elongation (GO:0030497)5.64240222
5* myelination (GO:0042552)5.63349807
6* axon ensheathment (GO:0008366)5.62680830
7* ensheathment of neurons (GO:0007272)5.62680830
8negative regulation of neurotransmitter secretion (GO:0046929)5.17116624
9L-amino acid import (GO:0043092)5.09541510
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.91493377
11neuron cell-cell adhesion (GO:0007158)4.80452471
12long-chain fatty acid biosynthetic process (GO:0042759)4.64146568
13postsynaptic membrane organization (GO:0001941)4.63579863
14presynaptic membrane assembly (GO:0097105)4.58637699
15locomotory exploration behavior (GO:0035641)4.57964199
16negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.44559986
17cellular potassium ion homeostasis (GO:0030007)4.41244570
18presynaptic membrane organization (GO:0097090)4.26338866
19negative regulation of neurotransmitter transport (GO:0051589)4.22051015
20neurotransmitter secretion (GO:0007269)4.21540251
21substantia nigra development (GO:0021762)4.16113494
22regulation of synaptic vesicle transport (GO:1902803)4.13592882
23amino acid import (GO:0043090)4.08383138
24glycerophospholipid catabolic process (GO:0046475)4.07898269
25regulation of collateral sprouting (GO:0048670)4.06106471
26peptidyl-tyrosine autophosphorylation (GO:0038083)3.99089413
27myelination in peripheral nervous system (GO:0022011)3.90841229
28peripheral nervous system axon ensheathment (GO:0032292)3.90841229
29oligodendrocyte differentiation (GO:0048709)3.90380363
30sodium ion export (GO:0071436)3.88472335
31regulation of neuronal synaptic plasticity (GO:0048168)3.83675144
32neurotransmitter-gated ion channel clustering (GO:0072578)3.83210363
33neuronal action potential propagation (GO:0019227)3.80975170
34cellular response to epinephrine stimulus (GO:0071872)3.80871616
35negative regulation of axon extension (GO:0030517)3.79273153
36response to redox state (GO:0051775)3.75233069
37cholesterol biosynthetic process (GO:0006695)3.73617129
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72918054
39* neuronal ion channel clustering (GO:0045161)3.70540983
40negative regulation of axonogenesis (GO:0050771)3.68001698
41positive regulation of synapse maturation (GO:0090129)3.64206932
42eye photoreceptor cell differentiation (GO:0001754)3.58646524
43photoreceptor cell differentiation (GO:0046530)3.58646524
44auditory behavior (GO:0031223)3.58061607
45cellular response to hepatocyte growth factor stimulus (GO:0035729)3.57320649
46response to hepatocyte growth factor (GO:0035728)3.57320649
47adhesion of symbiont to host cell (GO:0044650)3.53629161
48virion attachment to host cell (GO:0019062)3.53629161
49regulation of synapse structural plasticity (GO:0051823)3.52372612
50dendritic spine morphogenesis (GO:0060997)3.51973904
51cerebellar granule cell differentiation (GO:0021707)3.51810058
52regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50055685
53activated T cell proliferation (GO:0050798)3.47238136
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46126833
55adult walking behavior (GO:0007628)3.45650111
56regulation of glutamate receptor signaling pathway (GO:1900449)3.44678672
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43697006
58neurotransmitter transport (GO:0006836)3.41192615
59pyrimidine nucleobase catabolic process (GO:0006208)3.38960155
60cerebellar Purkinje cell differentiation (GO:0021702)3.37813339
61response to epinephrine (GO:0071871)3.37460925
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32373298
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32363363
64* transmission of nerve impulse (GO:0019226)3.31461377
65cell migration in hindbrain (GO:0021535)3.31388453
66potassium ion homeostasis (GO:0055075)3.29667034
67astrocyte development (GO:0014002)3.29208210
68positive regulation of action potential (GO:0045760)3.29053609
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27440750
70membrane depolarization during action potential (GO:0086010)3.26886107
71regulation of neurotransmitter secretion (GO:0046928)3.26191039
72positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.24481627
73synaptic vesicle maturation (GO:0016188)3.22800253
74sterol biosynthetic process (GO:0016126)3.20100604
75neuron recognition (GO:0008038)3.19515747
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19447523
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18972352
78positive regulation of dendritic spine development (GO:0060999)3.18882933
79regulation of neurotransmitter levels (GO:0001505)3.17056856
80import into cell (GO:0098657)3.16332306
81neuromuscular synaptic transmission (GO:0007274)3.16006705
82regulation of postsynaptic membrane potential (GO:0060078)3.15999921
83dendrite morphogenesis (GO:0048813)3.15416593
84potassium ion import (GO:0010107)3.13191682
85neurotransmitter catabolic process (GO:0042135)3.12657554
86regulation of neurotransmitter transport (GO:0051588)3.11559967
87cerebral cortex radially oriented cell migration (GO:0021799)3.11486987
88ionotropic glutamate receptor signaling pathway (GO:0035235)3.10302555
89cell communication by electrical coupling (GO:0010644)3.09002754
90regulation of synaptic vesicle exocytosis (GO:2000300)3.08768309
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07828804
92exploration behavior (GO:0035640)3.06961448
93Rap protein signal transduction (GO:0032486)3.04330380
94positive regulation of neurological system process (GO:0031646)3.04022953
95asymmetric protein localization (GO:0008105)3.03163690
96neuromuscular process controlling balance (GO:0050885)3.02217894
97layer formation in cerebral cortex (GO:0021819)3.01903783
98synaptic vesicle endocytosis (GO:0048488)2.99652288
99response to auditory stimulus (GO:0010996)2.98209141
100gamma-aminobutyric acid transport (GO:0015812)2.97622648
101regulation of synapse maturation (GO:0090128)2.97097083
102cellular response to catecholamine stimulus (GO:0071870)2.96999818
103cellular response to monoamine stimulus (GO:0071868)2.96999818
104axonal fasciculation (GO:0007413)2.96242422
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.96055473
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95354794
107membrane depolarization (GO:0051899)2.95091137
108regulation of vesicle fusion (GO:0031338)2.95076639
109positive regulation of neurotransmitter transport (GO:0051590)2.94493630
110synaptic vesicle exocytosis (GO:0016079)2.92988583
111positive regulation of membrane potential (GO:0045838)2.92393844
112apical protein localization (GO:0045176)2.92140699
113synapse assembly (GO:0007416)2.92106187
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.92013789
115regulation of synaptic plasticity (GO:0048167)2.91645488
116creatine metabolic process (GO:0006600)2.91526628
117negative regulation of protein localization to cell surface (GO:2000009)2.90659138
118long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.89977542
119establishment of mitochondrion localization (GO:0051654)2.89359060
120neural nucleus development (GO:0048857)2.87770546
121membrane assembly (GO:0071709)2.87609950
122nucleobase catabolic process (GO:0046113)2.87308695
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85315088
124synaptic transmission, glutamatergic (GO:0035249)2.84748191
125nerve growth factor signaling pathway (GO:0038180)2.84623347
126response to methylmercury (GO:0051597)2.83080590
127cell differentiation in hindbrain (GO:0021533)2.82384813
128protein palmitoylation (GO:0018345)2.79199175
129regulation of dendritic spine morphogenesis (GO:0061001)2.78895496
130cellular sodium ion homeostasis (GO:0006883)2.78189695
131dendritic spine organization (GO:0097061)2.78175734
132mechanosensory behavior (GO:0007638)2.77601514
133glutamate receptor signaling pathway (GO:0007215)2.77399900
134protein localization to synapse (GO:0035418)2.76665791
135vocalization behavior (GO:0071625)2.76203361
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76158096
137neuron-neuron synaptic transmission (GO:0007270)2.75833374
138regulation of dendrite morphogenesis (GO:0048814)2.75793761
139myelin maintenance (GO:0043217)2.74673383
140central nervous system projection neuron axonogenesis (GO:0021952)2.74637196
141regulation of respiratory system process (GO:0044065)2.73387474
142L-glutamate transport (GO:0015813)2.73219872
143positive regulation of synapse assembly (GO:0051965)2.73107401
144glutamate secretion (GO:0014047)2.72734690
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72656919
146long-term memory (GO:0007616)2.72055364
147acidic amino acid transport (GO:0015800)2.71880943
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71315158
149positive regulation of actin filament depolymerization (GO:0030836)2.70255018
150response to monoamine (GO:0071867)2.70092704
151response to catecholamine (GO:0071869)2.70092704
152isoprenoid biosynthetic process (GO:0008299)2.69826968
153mating behavior (GO:0007617)2.69811427
154membrane hyperpolarization (GO:0060081)2.66009851
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65128393
156semaphorin-plexin signaling pathway (GO:0071526)2.63848019
157limb bud formation (GO:0060174)2.61955927
158neuron remodeling (GO:0016322)2.58734063
159regulation of voltage-gated calcium channel activity (GO:1901385)2.58294613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59357065
2EZH2_22144423_ChIP-Seq_EOC_Human3.56884452
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77606320
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76928269
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70596274
6DROSHA_22980978_ChIP-Seq_HELA_Human2.47310452
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.43778976
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38724766
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38724766
10* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.33732697
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30303963
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22679258
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.21934125
14TAF15_26573619_Chip-Seq_HEK293_Human2.20936483
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18809308
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18410632
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17169658
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15531833
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11995982
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10526486
21AR_21572438_ChIP-Seq_LNCaP_Human2.08959172
22* REST_21632747_ChIP-Seq_MESCs_Mouse1.99574156
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98084507
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.88644174
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87791658
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81360136
27* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78276424
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73725287
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69301792
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69031563
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64187699
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.61232473
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60296593
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59104390
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57567137
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55833346
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.55626321
38ER_23166858_ChIP-Seq_MCF-7_Human1.55254468
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53514574
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50994865
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47475950
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47348018
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45932715
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.41375366
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41084339
46P300_19829295_ChIP-Seq_ESCs_Human1.39931312
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38754483
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37460028
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36737405
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.31860325
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30750608
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.29508116
53STAT3_23295773_ChIP-Seq_U87_Human1.29222366
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29168881
55VDR_22108803_ChIP-Seq_LS180_Human1.28841171
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28451422
57FUS_26573619_Chip-Seq_HEK293_Human1.26470382
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24076452
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22652539
60RNF2_27304074_Chip-Seq_NSC_Mouse1.18579440
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18442130
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17242567
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.16633505
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15194398
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14624164
66ZNF274_21170338_ChIP-Seq_K562_Hela1.14210585
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13924170
68* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13846385
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13174894
70* TCF4_23295773_ChIP-Seq_U87_Human1.12578588
71* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11860642
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11749702
73* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11550688
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.10764699
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10224689
76* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10140730
77* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09399327
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.09169279
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07741287
80KDM2B_26808549_Chip-Seq_K562_Human1.05807949
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04498961
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.04144921
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03490121
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03490121
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02883110
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01880228
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01366396
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01204534
89* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99953060
90* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99725799
91* RUNX2_22187159_ChIP-Seq_PCA_Human0.99209503
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99148075
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98653217
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98442686
95* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98406806
96ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96430814
97* AR_19668381_ChIP-Seq_PC3_Human0.95050084
98* CMYC_18555785_Chip-Seq_ESCs_Mouse0.94873753
99SOX9_26525672_Chip-Seq_HEART_Mouse0.94583797
100* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94344974
101AHR_22903824_ChIP-Seq_MCF-7_Human0.94187225
102* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94110843
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93575178
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92917512
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92815513
106TP53_16413492_ChIP-PET_HCT116_Human0.92800360
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.92128313
108AR_25329375_ChIP-Seq_VCAP_Human0.92079718
109* CTCF_27219007_Chip-Seq_Bcells_Human0.91578591
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.91403823
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91081881
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90850501
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.90371386
114* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89597588
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89515636
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89515636
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.89474054
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89285622
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.88982130
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87313103
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87146580
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87027172
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86553398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.63237758
2MP0000920_abnormal_myelination4.19172378
3MP0004859_abnormal_synaptic_plasticity4.16026231
4MP0004270_analgesia3.69596137
5MP0002064_seizures2.95038871
6MP0001486_abnormal_startle_reflex2.91640273
7MP0003635_abnormal_synaptic_transmissio2.90320178
8MP0009046_muscle_twitch2.75197175
9* MP0002272_abnormal_nervous_system2.72615002
10MP0009745_abnormal_behavioral_response2.69658888
11MP0004885_abnormal_endolymph2.67036388
12MP0004742_abnormal_vestibular_system2.59129210
13MP0000778_abnormal_nervous_system2.47860362
14MP0001529_abnormal_vocalization2.42591421
15MP0003329_amyloid_beta_deposits2.41109053
16MP0005423_abnormal_somatic_nervous2.32258894
17MP0001485_abnormal_pinna_reflex2.29389904
18MP0002734_abnormal_mechanical_nocicepti2.20915963
19MP0001905_abnormal_dopamine_level2.16083565
20MP0002063_abnormal_learning/memory/cond2.15205296
21* MP0003690_abnormal_glial_cell2.14712299
22MP0001440_abnormal_grooming_behavior2.10344577
23MP0002572_abnormal_emotion/affect_behav2.08655180
24MP0003634_abnormal_glial_cell2.07225945
25MP0005171_absent_coat_pigmentation2.04650133
26MP0004142_abnormal_muscle_tone1.93759728
27MP0005409_darkened_coat_color1.91258671
28MP0003879_abnormal_hair_cell1.88253933
29MP0002229_neurodegeneration1.82948051
30MP0005551_abnormal_eye_electrophysiolog1.80411723
31MP0000462_abnormal_digestive_system1.79184124
32MP0003632_abnormal_nervous_system1.72901205
33MP0002067_abnormal_sensory_capabilities1.70792890
34MP0003122_maternal_imprinting1.70629745
35MP0000955_abnormal_spinal_cord1.68815150
36* MP0002882_abnormal_neuron_morphology1.67316269
37MP0008569_lethality_at_weaning1.62680396
38MP0001968_abnormal_touch/_nociception1.59877928
39MP0005386_behavior/neurological_phenoty1.59207669
40MP0004924_abnormal_behavior1.59207669
41MP0002822_catalepsy1.54396918
42MP0003136_yellow_coat_color1.53849751
43MP0002733_abnormal_thermal_nociception1.52107229
44* MP0002066_abnormal_motor_capabilities/c1.45961223
45MP0001970_abnormal_pain_threshold1.44778863
46MP0001501_abnormal_sleep_pattern1.39005903
47MP0002184_abnormal_innervation1.30735031
48MP0002909_abnormal_adrenal_gland1.30516917
49MP0010386_abnormal_urinary_bladder1.29078701
50MP0001963_abnormal_hearing_physiology1.27827809
51MP0004145_abnormal_muscle_electrophysio1.27414810
52MP0001984_abnormal_olfaction1.27295145
53MP0002735_abnormal_chemical_nociception1.27144562
54MP0003950_abnormal_plasma_membrane1.26150724
55MP0003631_nervous_system_phenotype1.23886304
56* MP0002752_abnormal_somatic_nervous1.23874057
57MP0005623_abnormal_meninges_morphology1.22270573
58MP0002557_abnormal_social/conspecific_i1.21067409
59MP0004134_abnormal_chest_morphology1.20514172
60MP0003283_abnormal_digestive_organ1.20045148
61MP0001299_abnormal_eye_distance/1.19439089
62MP0002638_abnormal_pupillary_reflex1.15993591
63MP0002736_abnormal_nociception_after1.14719738
64MP0000604_amyloidosis1.14255196
65MP0000569_abnormal_digit_pigmentation1.14239146
66MP0002152_abnormal_brain_morphology1.11271819
67MP0004811_abnormal_neuron_physiology1.09225865
68MP0003123_paternal_imprinting1.08085454
69MP0009780_abnormal_chondrocyte_physiolo1.07975358
70MP0002090_abnormal_vision1.07430755
71MP0006072_abnormal_retinal_apoptosis1.07257443
72MP0005253_abnormal_eye_physiology1.06336841
73MP0001188_hyperpigmentation1.05827478
74MP0003633_abnormal_nervous_system1.05813129
75MP0001177_atelectasis1.02516216
76MP0005410_abnormal_fertilization1.01840985
77MP0001661_extended_life_span1.00593340
78MP0006276_abnormal_autonomic_nervous0.96943068
79MP0003938_abnormal_ear_development0.96895326
80MP0005195_abnormal_posterior_eye0.96767697
81MP0001502_abnormal_circadian_rhythm0.93945989
82MP0005646_abnormal_pituitary_gland0.93045249
83MP0003121_genomic_imprinting0.89621085
84MP0005645_abnormal_hypothalamus_physiol0.88479455
85MP0000026_abnormal_inner_ear0.87149179
86MP0001348_abnormal_lacrimal_gland0.85955843
87MP0000631_abnormal_neuroendocrine_gland0.84280995
88MP0000383_abnormal_hair_follicle0.83748528
89MP0010678_abnormal_skin_adnexa0.82604124
90MP0000747_muscle_weakness0.81690522
91MP0005451_abnormal_body_composition0.81508193
92MP0004147_increased_porphyrin_level0.80692929
93MP0005310_abnormal_salivary_gland0.79015271
94MP0000579_abnormal_nail_morphology0.77493409
95MP0004133_heterotaxia0.75359770
96MP0001346_abnormal_lacrimal_gland0.75140962
97MP0005394_taste/olfaction_phenotype0.71681172
98MP0005499_abnormal_olfactory_system0.71681172
99MP0004381_abnormal_hair_follicle0.70467849
100MP0004043_abnormal_pH_regulation0.69643357
101MP0002069_abnormal_eating/drinking_beha0.68863640
102MP0003861_abnormal_nervous_system0.66868521
103MP0001958_emphysema0.66847872
104MP0003137_abnormal_impulse_conducting0.66808009
105MP0008877_abnormal_DNA_methylation0.65418259
106MP0001727_abnormal_embryo_implantation0.63134795
107MP0008874_decreased_physiological_sensi0.63024691
108MP0004858_abnormal_nervous_system0.61822332
109MP0002295_abnormal_pulmonary_circulatio0.61434578
110MP0004085_abnormal_heartbeat0.61384994
111MP0003045_fibrosis0.61192354
112* MP0002082_postnatal_lethality0.60776556
113* MP0010770_preweaning_lethality0.60776556
114* MP0010769_abnormal_survival0.60611744
115MP0003172_abnormal_lysosome_physiology0.58849639
116MP0000751_myopathy0.58499281
117MP0003787_abnormal_imprinting0.57798412
118MP0008872_abnormal_physiological_respon0.56931069
119* MP0010768_mortality/aging0.56610575
120MP0005167_abnormal_blood-brain_barrier0.56330710
121MP0000566_synostosis0.56178879
122MP0003195_calcinosis0.56150858
123MP0004130_abnormal_muscle_cell0.56038865
124MP0003937_abnormal_limbs/digits/tail_de0.55624315
125MP0001943_abnormal_respiration0.55595656
126MP0001986_abnormal_taste_sensitivity0.55582460
127MP0002102_abnormal_ear_morphology0.55004365
128MP0003868_abnormal_feces_composition0.54867818
129MP0004185_abnormal_adipocyte_glucose0.54388049

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.95392315
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.95392315
3Sensory axonal neuropathy (HP:0003390)5.53084961
4Neurofibrillary tangles (HP:0002185)5.11434927
5Abnormality of the corticospinal tract (HP:0002492)4.92884799
6Peripheral hypomyelination (HP:0007182)4.12457185
7Atonic seizures (HP:0010819)4.12396808
8Spastic gait (HP:0002064)3.94754734
9Akinesia (HP:0002304)3.92271986
10Parakeratosis (HP:0001036)3.92017130
11Supranuclear gaze palsy (HP:0000605)3.87489890
12Intention tremor (HP:0002080)3.75055354
13Diplopia (HP:0000651)3.75009853
14Abnormality of binocular vision (HP:0011514)3.75009853
15Myokymia (HP:0002411)3.71706392
16Cerebral inclusion bodies (HP:0100314)3.71383721
17Focal motor seizures (HP:0011153)3.66425246
18Dysmetria (HP:0001310)3.55733029
19Limb dystonia (HP:0002451)3.49983726
20Cerebral hypomyelination (HP:0006808)3.42875920
21Torticollis (HP:0000473)3.25391511
22Alacrima (HP:0000522)3.22688379
23Scanning speech (HP:0002168)3.07239670
24Obstructive sleep apnea (HP:0002870)3.06790094
25Focal seizures (HP:0007359)3.06588877
26Epileptiform EEG discharges (HP:0011182)3.05026616
27Termporal pattern (HP:0011008)2.98593963
28Insidious onset (HP:0003587)2.98593963
29Onion bulb formation (HP:0003383)2.93766676
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.90518634
31Small epiphyses (HP:0010585)2.85927093
32Polyphagia (HP:0002591)2.85172112
33Genetic anticipation (HP:0003743)2.84634830
34EEG with generalized epileptiform discharges (HP:0011198)2.81175971
35Hemiparesis (HP:0001269)2.78749229
36Sleep apnea (HP:0010535)2.77920909
37Action tremor (HP:0002345)2.77439320
38Increased circulating renin level (HP:0000848)2.77364766
39Epileptic encephalopathy (HP:0200134)2.76513764
40Drooling (HP:0002307)2.74384533
41Impaired vibration sensation in the lower limbs (HP:0002166)2.67519134
42Truncal ataxia (HP:0002078)2.65833150
43Slow saccadic eye movements (HP:0000514)2.64969134
44Hypsarrhythmia (HP:0002521)2.64006236
45Decreased lacrimation (HP:0000633)2.62989819
46Premature skin wrinkling (HP:0100678)2.59496902
47Ankle clonus (HP:0011448)2.53518545
48Retinal dysplasia (HP:0007973)2.52431643
49Abnormality of the parathyroid morphology (HP:0011766)2.50785331
50Excessive salivation (HP:0003781)2.49538287
51Spastic paraparesis (HP:0002313)2.47821386
52Urinary urgency (HP:0000012)2.47429518
53Focal dystonia (HP:0004373)2.45464690
54Hemiplegia (HP:0002301)2.42866962
55Pheochromocytoma (HP:0002666)2.41901548
56Papilledema (HP:0001085)2.41613168
57Mutism (HP:0002300)2.41354095
58Fetal akinesia sequence (HP:0001989)2.40610683
59Amblyopia (HP:0000646)2.40066860
60Anteriorly placed anus (HP:0001545)2.39778618
61Dysdiadochokinesis (HP:0002075)2.38834470
62Abnormal auditory evoked potentials (HP:0006958)2.38739094
63Gaze-evoked nystagmus (HP:0000640)2.38593931
64Progressive cerebellar ataxia (HP:0002073)2.36924341
65Generalized myoclonic seizures (HP:0002123)2.33087992
66Abnormality of the lower motor neuron (HP:0002366)2.33014918
67Dialeptic seizures (HP:0011146)2.32282067
68Broad-based gait (HP:0002136)2.31790515
69Anxiety (HP:0000739)2.29570344
70Craniofacial dystonia (HP:0012179)2.29119190
71Lower limb muscle weakness (HP:0007340)2.28424984
72Status epilepticus (HP:0002133)2.24987075
73Leukodystrophy (HP:0002415)2.21341399
74Prolonged QT interval (HP:0001657)2.19318707
75Absence seizures (HP:0002121)2.19233624
76Abnormality of macular pigmentation (HP:0008002)2.18608343
77Partial agenesis of the corpus callosum (HP:0001338)2.18362445
78Relative macrocephaly (HP:0004482)2.18015189
79Hypoplastic pelvis (HP:0008839)2.15961205
80Urinary bladder sphincter dysfunction (HP:0002839)2.15625471
81Hypomagnesemia (HP:0002917)2.15333465
82Depression (HP:0000716)2.15292959
83Cerebral hemorrhage (HP:0001342)2.15175275
84Increased serum pyruvate (HP:0003542)2.14407532
85Abnormality of glycolysis (HP:0004366)2.14407532
86Anomalous pulmonary venous return (HP:0010772)2.14043701
87Thickened helices (HP:0000391)2.12123670
88Neuroendocrine neoplasm (HP:0100634)2.10747013
89Hypoventilation (HP:0002791)2.10623844
90Megalencephaly (HP:0001355)2.10521158
91Diminished movement (HP:0002374)2.09194962
92Cupped ear (HP:0000378)2.08442949
93Clumsiness (HP:0002312)2.08220635
94Impaired smooth pursuit (HP:0007772)2.06810331
95Insomnia (HP:0100785)2.05155025
96Bowel incontinence (HP:0002607)2.04909554
97Split foot (HP:0001839)2.03237155
98Clonus (HP:0002169)2.01896313
99CNS hypomyelination (HP:0003429)2.00321206
100Visual hallucinations (HP:0002367)1.98855224
101Aplasia involving bones of the upper limbs (HP:0009823)1.98457689
102Aplasia of the phalanges of the hand (HP:0009802)1.98457689
103Aplasia involving bones of the extremities (HP:0009825)1.98457689
104Absent septum pellucidum (HP:0001331)1.97766198
105Morphological abnormality of the pyramidal tract (HP:0002062)1.97671954
106Morphological abnormality of the inner ear (HP:0011390)1.97153580
107Hyperventilation (HP:0002883)1.96404110
108Central scotoma (HP:0000603)1.95118876
109Poor eye contact (HP:0000817)1.94702458
110Abolished electroretinogram (ERG) (HP:0000550)1.93791269
111Abnormal eating behavior (HP:0100738)1.92558673
112Decreased central vision (HP:0007663)1.92154559
113Congenital ichthyosiform erythroderma (HP:0007431)1.91050225
114Spastic tetraplegia (HP:0002510)1.90952594
115Steppage gait (HP:0003376)1.90679661
116Bronchomalacia (HP:0002780)1.90288215
117Gait imbalance (HP:0002141)1.90080089
118Broad metatarsal (HP:0001783)1.88916880
119Abnormal large intestine physiology (HP:0012700)1.88384339
120Turricephaly (HP:0000262)1.88334510
121Epiphyseal dysplasia (HP:0002656)1.88297692
122Impaired vibratory sensation (HP:0002495)1.85863161
123Abnormality of ocular smooth pursuit (HP:0000617)1.84983138
124Impaired social interactions (HP:0000735)1.83864776
125Abnormal social behavior (HP:0012433)1.83864776
126Chin dimple (HP:0010751)1.81584486
127Bradykinesia (HP:0002067)1.80437714
128Paraplegia (HP:0010550)1.79886084
129Generalized tonic-clonic seizures (HP:0002069)1.78860086
130Hypoplasia of the corpus callosum (HP:0002079)1.78655041
131Abnormality of the pulmonary veins (HP:0011718)1.78633361
132Type II lissencephaly (HP:0007260)1.78216095
133Agitation (HP:0000713)1.77997694
134Shallow orbits (HP:0000586)1.76655135
135Widely spaced teeth (HP:0000687)1.76547017
136Esophageal atresia (HP:0002032)1.76435534
137Protruding tongue (HP:0010808)1.76363230
138Blue irides (HP:0000635)1.76292523
139Vaginal atresia (HP:0000148)1.76036851
140Coronal craniosynostosis (HP:0004440)1.75296820
141Febrile seizures (HP:0002373)1.75021004
142Poor speech (HP:0002465)1.75018880
143Abnormal EKG (HP:0003115)1.74985311
144Amyotrophic lateral sclerosis (HP:0007354)1.74785597
145Progressive inability to walk (HP:0002505)1.73749427
146Humeroradial synostosis (HP:0003041)1.73001026
147Synostosis involving the elbow (HP:0003938)1.73001026
148Absent speech (HP:0001344)1.72883131
149Postural instability (HP:0002172)1.71778355
150Stereotypic behavior (HP:0000733)1.71047749
151Apathy (HP:0000741)1.69365317
152Incomplete penetrance (HP:0003829)1.67703119
153Spastic tetraparesis (HP:0001285)1.66906059
154Spastic paraplegia (HP:0001258)1.65125909
155Syncope (HP:0001279)1.64889464
156Annular pancreas (HP:0001734)1.64344521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.63598881
2STK395.38419568
3OXSR14.03938822
4EPHB12.81597617
5EPHA42.43081284
6CDK192.37765081
7ICK2.34517955
8BCR2.34129867
9TYRO32.31867192
10PRPF4B2.30077289
11UHMK12.10997860
12PKN12.06733542
13WNK42.04759643
14PAK61.98529524
15NEK61.95507548
16SIK21.86758138
17NTRK11.81319745
18MARK11.75878901
19FES1.68230084
20NTRK31.61896883
21WNK11.61676973
22FGFR21.57433054
23PNCK1.56510417
24PINK11.53372690
25MAPK131.50290504
26CASK1.40234811
27IRAK21.37450310
28CSNK1G31.36599235
29ROCK21.34461979
30MET1.31047644
31CSNK1A1L1.24827982
32MAP3K91.20487563
33SGK21.20053925
34CAMK11.19315668
35RIPK11.18499402
36CSNK1G21.17459415
37FGR1.13425298
38PBK1.11924448
39LIMK11.11714536
40MINK11.11381011
41CAMK2B1.10972022
42CDK51.10694737
43PAK31.09922780
44FRK1.09020646
45NTRK21.06685925
46MAP3K41.03368920
47CLK11.00330099
48CAMK2D1.00149122
49LATS20.98386128
50CSNK1G10.97907899
51IRAK10.95948746
52CDK140.90005109
53STK380.88843292
54SGK2230.88300926
55SGK4940.88300926
56MAP3K20.86762763
57SGK30.85353376
58KSR20.84672567
59MARK20.81298845
60CAMK2A0.80126646
61CDK150.78114648
62AKT30.77572756
63CDK180.75033148
64PRKCQ0.74534029
65FYN0.72255199
66EPHA30.71859555
67CDK11A0.69998096
68MAP2K70.66372494
69ARAF0.65906692
70CAMK2G0.65630003
71MAPKAPK50.65490999
72ROCK10.64794805
73INSRR0.64032432
74PHKG10.63478971
75PHKG20.63478971
76PDPK10.63082951
77MST40.62555936
78CAMK1D0.62554955
79PRKCZ0.62146469
80RPS6KA30.60831345
81STK110.59698189
82ERBB20.58177749
83RPS6KA20.58146711
84CAMK40.57957059
85PRKCG0.56171020
86DDR20.56091188
87PRKCE0.55372336
88DAPK10.55150823
89MAP3K130.53642705
90PDGFRB0.52349158
91DYRK20.51603644
92PRKCH0.48580611
93MAPK120.48336364
94PDGFRA0.48159599
95PRKAA10.44996901
96MAPK150.44644304
97ERBB40.43222046
98KSR10.42166833
99DMPK0.41132901
100MUSK0.40933011
101ADRBK20.39649131
102PRKG10.39294444
103PDK10.38829393
104MAP4K20.38596854
105MAPK80.37926494
106IRAK40.37330700
107CAMK1G0.36891629
108CSNK1D0.36785701
109GRK10.36396843
110WNK30.36218234
111PRKD10.35798874
112DYRK1A0.34584193
113RET0.34059207
114MAP2K40.33973483
115CSNK1A10.33366621
116PLK20.32900286
117DAPK20.32684188
118SGK10.32574321
119PTK20.32408636
120PRKACA0.32202997
121GRK50.32197956
122CAMKK20.31129647
123PRKD30.31018378
124CSK0.30859075
125MAPK100.30509564
126INSR0.30245195
127ALK0.30029632
128CAMKK10.29218186

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.33257408
2Steroid biosynthesis_Homo sapiens_hsa001003.48470888
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90164188
4Fatty acid elongation_Homo sapiens_hsa000622.70202230
5Ether lipid metabolism_Homo sapiens_hsa005652.52195894
6Axon guidance_Homo sapiens_hsa043602.48659014
7Glutamatergic synapse_Homo sapiens_hsa047242.43975523
8Nicotine addiction_Homo sapiens_hsa050332.24186382
9GABAergic synapse_Homo sapiens_hsa047272.21601440
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07585969
11Synaptic vesicle cycle_Homo sapiens_hsa047212.06434677
12Serotonergic synapse_Homo sapiens_hsa047261.92151994
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84350214
14Morphine addiction_Homo sapiens_hsa050321.82889473
15Circadian entrainment_Homo sapiens_hsa047131.67683576
16Cholinergic synapse_Homo sapiens_hsa047251.65005690
17Long-term depression_Homo sapiens_hsa047301.64247233
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57585381
19Collecting duct acid secretion_Homo sapiens_hsa049661.55878734
20Dopaminergic synapse_Homo sapiens_hsa047281.49640964
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48583088
22Oxidative phosphorylation_Homo sapiens_hsa001901.45572427
23* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42673626
24Salivary secretion_Homo sapiens_hsa049701.42646479
25Long-term potentiation_Homo sapiens_hsa047201.39609573
26Sphingolipid metabolism_Homo sapiens_hsa006001.33373500
27Phototransduction_Homo sapiens_hsa047441.32879141
28Vibrio cholerae infection_Homo sapiens_hsa051101.29823447
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25963087
30Butanoate metabolism_Homo sapiens_hsa006501.23862925
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.20573221
32Renal cell carcinoma_Homo sapiens_hsa052111.19618665
33Sulfur metabolism_Homo sapiens_hsa009201.17714118
34Amphetamine addiction_Homo sapiens_hsa050311.17270049
35Olfactory transduction_Homo sapiens_hsa047401.13347301
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12578337
37Gastric acid secretion_Homo sapiens_hsa049711.11806247
38Alzheimers disease_Homo sapiens_hsa050101.11629843
39Cocaine addiction_Homo sapiens_hsa050301.04872035
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00511606
41ErbB signaling pathway_Homo sapiens_hsa040121.00102794
42Oxytocin signaling pathway_Homo sapiens_hsa049210.99684325
43Dilated cardiomyopathy_Homo sapiens_hsa054140.99585263
44Bile secretion_Homo sapiens_hsa049760.99371803
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97575454
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96982663
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94895373
48Choline metabolism in cancer_Homo sapiens_hsa052310.94648985
49Taste transduction_Homo sapiens_hsa047420.94483141
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91198703
51Insulin secretion_Homo sapiens_hsa049110.90624678
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89182401
53Gap junction_Homo sapiens_hsa045400.89047457
54Cardiac muscle contraction_Homo sapiens_hsa042600.88686507
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.88671710
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.87986485
57Ras signaling pathway_Homo sapiens_hsa040140.87823379
58Pancreatic secretion_Homo sapiens_hsa049720.86591955
59Renin secretion_Homo sapiens_hsa049240.85988491
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85600725
61GnRH signaling pathway_Homo sapiens_hsa049120.81220527
62Endocytosis_Homo sapiens_hsa041440.81117511
63Rap1 signaling pathway_Homo sapiens_hsa040150.80788381
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79914241
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79852968
66Tight junction_Homo sapiens_hsa045300.79665139
67Calcium signaling pathway_Homo sapiens_hsa040200.79634065
68cAMP signaling pathway_Homo sapiens_hsa040240.79367607
69Parkinsons disease_Homo sapiens_hsa050120.79335187
70Vitamin B6 metabolism_Homo sapiens_hsa007500.79072911
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78901780
72Histidine metabolism_Homo sapiens_hsa003400.76518965
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75498959
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74722164
75Rheumatoid arthritis_Homo sapiens_hsa053230.73613957
76Circadian rhythm_Homo sapiens_hsa047100.71996269
77Protein export_Homo sapiens_hsa030600.71761499
78Type II diabetes mellitus_Homo sapiens_hsa049300.69247032
79Ovarian steroidogenesis_Homo sapiens_hsa049130.68961332
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68776301
81Dorso-ventral axis formation_Homo sapiens_hsa043200.68205589
82Linoleic acid metabolism_Homo sapiens_hsa005910.66397352
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65322820
84Inositol phosphate metabolism_Homo sapiens_hsa005620.64171225
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63569813
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60718622
87Fatty acid biosynthesis_Homo sapiens_hsa000610.60589463
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60517107
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.58478817
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58452221
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56439242
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56369335
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.56326927
94Glucagon signaling pathway_Homo sapiens_hsa049220.55754213
95beta-Alanine metabolism_Homo sapiens_hsa004100.55594807
96Oocyte meiosis_Homo sapiens_hsa041140.54532199
97MAPK signaling pathway_Homo sapiens_hsa040100.53448850
98Hippo signaling pathway_Homo sapiens_hsa043900.51147948
99Fatty acid metabolism_Homo sapiens_hsa012120.49758536
100Estrogen signaling pathway_Homo sapiens_hsa049150.48966536
101ABC transporters_Homo sapiens_hsa020100.46629633
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46549575
103Thyroid hormone synthesis_Homo sapiens_hsa049180.46145310
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44657902
105Melanogenesis_Homo sapiens_hsa049160.44336391
106Alcoholism_Homo sapiens_hsa050340.42187674
107ECM-receptor interaction_Homo sapiens_hsa045120.40952578
108Prion diseases_Homo sapiens_hsa050200.40295981
109Protein digestion and absorption_Homo sapiens_hsa049740.39780394
110VEGF signaling pathway_Homo sapiens_hsa043700.39533829
111Huntingtons disease_Homo sapiens_hsa050160.38785355
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38708520
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38699635
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38465111
115Mineral absorption_Homo sapiens_hsa049780.36667300
116AMPK signaling pathway_Homo sapiens_hsa041520.36136136
117Lysosome_Homo sapiens_hsa041420.36131847
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35416233
119Glioma_Homo sapiens_hsa052140.34893937
120Arginine and proline metabolism_Homo sapiens_hsa003300.34413630
121mTOR signaling pathway_Homo sapiens_hsa041500.34342364
122Phagosome_Homo sapiens_hsa041450.33401996
123Chemokine signaling pathway_Homo sapiens_hsa040620.33160077
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31285281
125Focal adhesion_Homo sapiens_hsa045100.31089142
126Hedgehog signaling pathway_Homo sapiens_hsa043400.29876148
127T cell receptor signaling pathway_Homo sapiens_hsa046600.29216500
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28527726
129Wnt signaling pathway_Homo sapiens_hsa043100.27617050
130Autoimmune thyroid disease_Homo sapiens_hsa053200.27258518
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26253318

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