NEUROG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.92357034
2intestinal epithelial cell development (GO:0060576)6.54190873
3atrioventricular valve morphogenesis (GO:0003181)6.51969095
4neuronal stem cell maintenance (GO:0097150)5.78143274
5positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.62502622
6exocrine pancreas development (GO:0031017)5.61117664
7uterus development (GO:0060065)5.61094378
8* endocrine pancreas development (GO:0031018)5.57585983
9axon extension involved in axon guidance (GO:0048846)5.53139833
10neuron projection extension involved in neuron projection guidance (GO:1902284)5.53139833
11cellular response to ATP (GO:0071318)5.49720281
12regulation of bile acid biosynthetic process (GO:0070857)5.48227205
13response to UV-B (GO:0010224)5.38936443
14axonemal dynein complex assembly (GO:0070286)5.28819029
15neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.23753819
16response to food (GO:0032094)5.16902088
17negative regulation of leukocyte chemotaxis (GO:0002689)5.11470791
18positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.92171076
19negative regulation of axon extension involved in axon guidance (GO:0048843)4.85290382
20negative regulation of axon guidance (GO:1902668)4.78906147
21striated muscle atrophy (GO:0014891)4.57242395
22endocardial cushion morphogenesis (GO:0003203)4.56459893
23seminiferous tubule development (GO:0072520)4.47385540
24acyl-CoA biosynthetic process (GO:0071616)4.46043615
25thioester biosynthetic process (GO:0035384)4.46043615
26fatty-acyl-CoA biosynthetic process (GO:0046949)4.42255957
27chemosensory behavior (GO:0007635)4.41400176
28positive regulation of sodium ion transmembrane transport (GO:1902307)4.41370259
29* hindbrain development (GO:0030902)4.40853757
30DNA strand renaturation (GO:0000733)4.39046325
31negative regulation of translation, ncRNA-mediated (GO:0040033)4.33064061
32regulation of translation, ncRNA-mediated (GO:0045974)4.33064061
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.33064061
34protein localization to synapse (GO:0035418)4.32046421
35fatty acid elongation (GO:0030497)4.31368377
36acetyl-CoA metabolic process (GO:0006084)4.29227685
37regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.23271761
38negative regulation of chondrocyte differentiation (GO:0032331)4.22314104
39fatty acid homeostasis (GO:0055089)4.19438966
40positive regulation of astrocyte differentiation (GO:0048711)4.16965645
41COPI coating of Golgi vesicle (GO:0048205)4.14164145
42Golgi transport vesicle coating (GO:0048200)4.14164145
43negative regulation of smooth muscle cell differentiation (GO:0051151)4.13585418
44positive regulation of synapse maturation (GO:0090129)4.07664010
45regulation of inositol phosphate biosynthetic process (GO:0010919)4.07442088
46triglyceride biosynthetic process (GO:0019432)4.03056240
47acylglycerol biosynthetic process (GO:0046463)3.89910901
48neutral lipid biosynthetic process (GO:0046460)3.89910901
49low-density lipoprotein particle clearance (GO:0034383)3.88811972
50mitotic G2 DNA damage checkpoint (GO:0007095)3.88296085
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.88286745
52negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.87103559
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.86524156
54auditory behavior (GO:0031223)3.85193137
55negative regulation of interleukin-1 beta production (GO:0032691)3.84693668
56protein retention in ER lumen (GO:0006621)3.83031781
57response to auditory stimulus (GO:0010996)3.78550494
58primary alcohol catabolic process (GO:0034310)3.77475591
59epithelial cell fate commitment (GO:0072148)3.75050644
60regulation of podosome assembly (GO:0071801)3.74096328
61serotonin metabolic process (GO:0042428)3.68682913
62mechanosensory behavior (GO:0007638)3.68217565
63negative regulation of cell cycle G2/M phase transition (GO:1902750)3.68118125
64muscle atrophy (GO:0014889)3.65813524
65diacylglycerol metabolic process (GO:0046339)3.65614749
66glandular epithelial cell differentiation (GO:0002067)3.64383882
67mesenchyme morphogenesis (GO:0072132)3.62371061
68fatty-acyl-CoA metabolic process (GO:0035337)3.61404787
69myelin maintenance (GO:0043217)3.60112589
70cell morphogenesis involved in neuron differentiation (GO:0048667)3.58326072
71regulation of triglyceride biosynthetic process (GO:0010866)3.58094223
72positive regulation of fatty acid metabolic process (GO:0045923)3.55693582
73skeletal muscle adaptation (GO:0043501)3.55209255
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.53581122
75cerebellar granule cell differentiation (GO:0021707)3.50594366
76negative regulation of chemotaxis (GO:0050922)3.50208444
77negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.49940751
78positive regulation of gastrulation (GO:2000543)3.49870836
79organ formation (GO:0048645)3.46996563
80behavioral response to pain (GO:0048266)3.46912791
81vocalization behavior (GO:0071625)3.46168418
82tongue development (GO:0043586)3.44385347
83nicotinamide nucleotide biosynthetic process (GO:0019359)3.43709537
84pyridine nucleotide biosynthetic process (GO:0019363)3.43709537
85primary amino compound metabolic process (GO:1901160)3.43264941
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.42304806
87oocyte development (GO:0048599)3.40654538
88polarized epithelial cell differentiation (GO:0030859)3.40535736
89columnar/cuboidal epithelial cell development (GO:0002066)3.40498506
90reflex (GO:0060004)3.40176159
91bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40095150
92regulation of mitochondrial membrane permeability (GO:0046902)3.39640897
93neuronal action potential (GO:0019228)3.38011479
94positive regulation of synapse assembly (GO:0051965)3.34000194
95regulation of synapse maturation (GO:0090128)3.33887155
96mitotic G2/M transition checkpoint (GO:0044818)3.33434560
97multicellular organismal movement (GO:0050879)3.32835644
98musculoskeletal movement (GO:0050881)3.32835644
99glucocorticoid receptor signaling pathway (GO:0042921)3.32706452
100neurotransmitter-gated ion channel clustering (GO:0072578)3.32340653
101establishment of nucleus localization (GO:0040023)3.31846730
102startle response (GO:0001964)3.28819079
103epithelial cell differentiation involved in prostate gland development (GO:0060742)3.28729829
104regulation of water loss via skin (GO:0033561)3.27308714
105negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.27028547
106regulation of membrane permeability (GO:0090559)3.25050552
107regulation of synapse assembly (GO:0051963)3.24266372
108retinal ganglion cell axon guidance (GO:0031290)3.23387694
109regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20481762
110positive regulation of endothelial cell apoptotic process (GO:2000353)3.20459518
111adult feeding behavior (GO:0008343)3.19388951
112glial cell proliferation (GO:0014009)3.18243215
113single strand break repair (GO:0000012)3.17478966
114establishment of apical/basal cell polarity (GO:0035089)3.15457248
115neurotransmitter catabolic process (GO:0042135)3.15188353
116regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.14136836
117establishment of epithelial cell polarity (GO:0090162)3.14019982
118regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.13660585
119response to acidic pH (GO:0010447)3.12661816
120calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.12206149
121cellular response to pH (GO:0071467)3.11681389
122response to pheromone (GO:0019236)3.11078764
123negative regulation of cartilage development (GO:0061037)3.10921337
124positive regulation of triglyceride biosynthetic process (GO:0010867)3.10911168
125limb bud formation (GO:0060174)3.10331901
126mesenchymal cell proliferation (GO:0010463)3.09992976
127regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.08992071
128neuron maturation (GO:0042551)3.05382709
129ovulation cycle (GO:0042698)3.04346599
130lung-associated mesenchyme development (GO:0060484)3.03543987
131negative regulation of oligodendrocyte differentiation (GO:0048715)3.03470979
132proline biosynthetic process (GO:0006561)3.02700968
133postsynaptic membrane organization (GO:0001941)3.02456680
134pyridine-containing compound biosynthetic process (GO:0072525)3.01958561
135positive regulation of alcohol biosynthetic process (GO:1902932)3.00857410
136cellular response to antibiotic (GO:0071236)3.00740229
137white fat cell differentiation (GO:0050872)2.99201618
138regulation of anoikis (GO:2000209)2.99094616
139filopodium assembly (GO:0046847)2.97857659
140rRNA transcription (GO:0009303)2.95782950
141regulation of sequestering of triglyceride (GO:0010889)2.95669282
142DNA topological change (GO:0006265)2.93360657
143cranial nerve morphogenesis (GO:0021602)2.92928913
144CDP-diacylglycerol biosynthetic process (GO:0016024)2.91952495
145neurotransmitter metabolic process (GO:0042133)2.89464954
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.89443126
147T cell lineage commitment (GO:0002360)2.88620663
148negative regulation of interleukin-1 production (GO:0032692)2.87917574
149regulation of axon guidance (GO:1902667)2.85728937
150desmosome organization (GO:0002934)2.85059203
151cell proliferation involved in kidney development (GO:0072111)2.84120008
152neurogenesis (GO:0022008)2.83297602
153mitotic G1 DNA damage checkpoint (GO:0031571)2.82589892
154alpha-linolenic acid metabolic process (GO:0036109)2.80969167
155coronary vasculature morphogenesis (GO:0060977)2.80704437
156apoptotic process involved in morphogenesis (GO:0060561)2.80524943
157establishment or maintenance of monopolar cell polarity (GO:0061339)2.80520579
158establishment of monopolar cell polarity (GO:0061162)2.80520579
159cellular anion homeostasis (GO:0030002)2.79522437
160negative regulation of hormone metabolic process (GO:0032351)2.78842527
161negative regulation of hormone biosynthetic process (GO:0032353)2.78842527
162positive regulation of cAMP-mediated signaling (GO:0043950)2.76229288
163positive regulation of receptor biosynthetic process (GO:0010870)2.74842616
164regulation of triglyceride catabolic process (GO:0010896)2.72902932
165dorsal/ventral axis specification (GO:0009950)2.72899666
166regulation of triglyceride metabolic process (GO:0090207)2.72331871
167positive regulation of triglyceride metabolic process (GO:0090208)2.71390751
168biotin metabolic process (GO:0006768)2.71146979
169positive regulation of cell size (GO:0045793)2.70886400
170positive regulation of fatty acid oxidation (GO:0046321)2.70256805
171regulation of extracellular matrix organization (GO:1903053)2.69806816
172negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.69550846
173histone H2B ubiquitination (GO:0033523)2.68349037
174acyl-CoA metabolic process (GO:0006637)2.67896154
175negative regulation of glial cell proliferation (GO:0060253)2.65896182
176pancreas development (GO:0031016)2.65427815
177positive regulation of osteoblast proliferation (GO:0033690)2.64874760
178regulation of axon extension involved in axon guidance (GO:0048841)2.63802517
179mitotic G1/S transition checkpoint (GO:0044819)2.60748229
180heart valve morphogenesis (GO:0003179)2.60118387
181positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60104433
182ectodermal placode formation (GO:0060788)2.59765966
183cell proliferation involved in metanephros development (GO:0072203)2.57965678
184nephron tubule morphogenesis (GO:0072078)2.57717101
185nephron epithelium morphogenesis (GO:0072088)2.57717101
186phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57200165
187cardiac left ventricle morphogenesis (GO:0003214)2.56795982
188negative regulation of behavior (GO:0048521)2.56795565
189Rac protein signal transduction (GO:0016601)2.56514146
190adhesion of symbiont to host cell (GO:0044650)2.54863149
191virion attachment to host cell (GO:0019062)2.54863149
192activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52400011
193growth hormone secretion (GO:0030252)2.50161464
194retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.49808509
195mitotic DNA integrity checkpoint (GO:0044774)2.49619108
196establishment of skin barrier (GO:0061436)2.49611894
197positive regulation of smoothened signaling pathway (GO:0045880)2.48882571
198type B pancreatic cell development (GO:0003323)2.47841240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.34338650
2EZH2_22144423_ChIP-Seq_EOC_Human7.86473529
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.55269340
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.31167919
5STAT6_21828071_ChIP-Seq_BEAS2B_Human4.22872369
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93644874
7VDR_21846776_ChIP-Seq_THP-1_Human2.96699880
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.95947654
9E2F7_22180533_ChIP-Seq_HELA_Human2.91690067
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76986924
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.67231927
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.58313034
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.56516409
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53930274
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.34429865
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.32057991
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31084537
18* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31084537
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.28691727
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25417226
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21295351
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.20393674
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18555418
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16009904
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.03566345
26* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99531888
27* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95698483
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90530550
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89568523
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.88675654
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.84746171
32VDR_24763502_ChIP-Seq_THP-1_Human1.84697502
33OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.83724073
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83609461
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82649645
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81250999
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80487868
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78897817
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77902518
40* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77306228
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74005574
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71329610
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71255235
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68749662
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.64655934
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63795856
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.62372097
48* REST_21632747_ChIP-Seq_MESCs_Mouse1.62329227
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58598304
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56815404
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56257976
52RACK7_27058665_Chip-Seq_MCF-7_Human1.55130608
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54530759
54* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54520338
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53523822
56P68_20966046_ChIP-Seq_HELA_Human1.53156752
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.53138454
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52069804
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50375807
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50357294
61DROSHA_22980978_ChIP-Seq_HELA_Human1.49741877
62ZNF263_19887448_ChIP-Seq_K562_Human1.48600860
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47948940
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47064434
65* REST_18959480_ChIP-ChIP_MESCs_Mouse1.46790826
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46289970
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45981525
68VDR_22108803_ChIP-Seq_LS180_Human1.41313900
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39916365
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.39891451
71* TP53_20018659_ChIP-ChIP_R1E_Mouse1.39409728
72TP53_18474530_ChIP-ChIP_U2OS_Human1.38603394
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36640276
74LXR_22292898_ChIP-Seq_THP-1_Human1.36599275
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.36131805
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35209466
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34533480
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34077088
79SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31517859
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31047918
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30870637
82CLOCK_20551151_ChIP-Seq_293T_Human1.28333383
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28027853
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27347996
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26722092
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.25656596
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25558434
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25105993
89GATA6_25053715_ChIP-Seq_YYC3_Human1.24652109
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24023345
91RNF2_27304074_Chip-Seq_NSC_Mouse1.23338584
92KDM2B_26808549_Chip-Seq_K562_Human1.22747600
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22546724
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20592563
95KDM2B_26808549_Chip-Seq_DND41_Human1.20569839
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19881399
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.19853102
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.19659051
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.19326285
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.18817602
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17733196
102* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16788863
103TCF7_22412390_ChIP-Seq_EML_Mouse1.16255285
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.16078223
105* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15285482
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14753596
107P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12293891
108* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11162438
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11157688
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10509919
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09729951
112TP53_16413492_ChIP-PET_HCT116_Human1.09577516
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09389866
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09155461
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08877368
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08598035
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08507789
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07884672
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07632815
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07392029
121MYC_22102868_ChIP-Seq_BL_Human1.07381639
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06387255
123CTCF_27219007_Chip-Seq_Bcells_Human1.05978413
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05768860
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04159115
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03665223
127TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03638671
128MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03278578
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03253764
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02996382
131JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02275674
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02217867
133GATA4_25053715_ChIP-Seq_YYC3_Human1.01358398
134SA1_27219007_Chip-Seq_ERYTHROID_Human1.01252354
135* KLF4_19829295_ChIP-Seq_ESCs_Human1.00566271
136PHF8_20622854_ChIP-Seq_HELA_Human0.99837004
137VDR_24787735_ChIP-Seq_THP-1_Human0.99502623
138BCOR_27268052_Chip-Seq_Bcells_Human0.98983614
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.98586221
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98438920
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97949342
142TP53_23651856_ChIP-Seq_MEFs_Mouse0.97202150
143CHD1_26751641_Chip-Seq_LNCaP_Human0.96946161
144SOX2_20726797_ChIP-Seq_SW620_Human0.96855863
145ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96788148
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94898331
147SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94576715
148* CREB1_26743006_Chip-Seq_LNCaP_Human0.94038625
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.92923042
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.92923042
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92676278
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92572276
153BCL6_27268052_Chip-Seq_Bcells_Human0.92460088
154* AR_19668381_ChIP-Seq_PC3_Human0.92147105
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.91968739
156TP53_22127205_ChIP-Seq_IMR90_Human0.91766465
157POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91129055
158GF1_26923725_Chip-Seq_HPCs_Mouse0.88999818
159* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88660602
160FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88513466
161* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88356691
162OCT4_19829295_ChIP-Seq_ESCs_Human0.88054352
163KLF5_25053715_ChIP-Seq_YYC3_Human0.87097065
164* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87013267
165SMC4_20622854_ChIP-Seq_HELA_Human0.86665789
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.86408554
167CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85709894
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85252627
169E2F1_20622854_ChIP-Seq_HELA_Human0.85173555
170IRF1_19129219_ChIP-ChIP_H3396_Human0.85128352
171* RAC3_21632823_ChIP-Seq_H3396_Human0.84633641
172HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84313420
173SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81232701
174* CTCF_20526341_ChIP-Seq_ESCs_Human0.81125344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.98863204
2MP0001986_abnormal_taste_sensitivity5.34118705
3MP0003122_maternal_imprinting5.10333972
4MP0003283_abnormal_digestive_organ4.78266479
5MP0003123_paternal_imprinting4.50472329
6MP0005645_abnormal_hypothalamus_physiol3.96735002
7MP0010234_abnormal_vibrissa_follicle3.88341334
8MP0008872_abnormal_physiological_respon3.72232903
9MP0005084_abnormal_gallbladder_morpholo3.46314344
10MP0002735_abnormal_chemical_nociception3.41105146
11MP0003693_abnormal_embryo_hatching3.32869614
12MP0005670_abnormal_white_adipose3.21556531
13MP0005451_abnormal_body_composition3.16350430
14* MP0005220_abnormal_exocrine_pancreas3.09547823
15MP0004130_abnormal_muscle_cell2.96922200
16MP0004264_abnormal_extraembryonic_tissu2.94717729
17MP0005666_abnormal_adipose_tissue2.90409935
18MP0005448_abnormal_energy_balance2.81478979
19MP0001501_abnormal_sleep_pattern2.73309498
20MP0003941_abnormal_skin_development2.66307938
21MP0001440_abnormal_grooming_behavior2.57607700
22MP0003315_abnormal_perineum_morphology2.50614113
23MP0009278_abnormal_bone_marrow2.50107718
24MP0005187_abnormal_penis_morphology2.32164184
25MP0002734_abnormal_mechanical_nocicepti2.28079471
26* MP0003119_abnormal_digestive_system2.26232997
27MP0002796_impaired_skin_barrier2.25147780
28MP0000537_abnormal_urethra_morphology2.24271168
29MP0006054_spinal_hemorrhage2.16696068
30MP0002733_abnormal_thermal_nociception2.13893181
31MP0005623_abnormal_meninges_morphology1.98936943
32MP0005647_abnormal_sex_gland1.96027307
33MP0000462_abnormal_digestive_system1.95965586
34MP0002971_abnormal_brown_adipose1.88499023
35MP0001919_abnormal_reproductive_system1.87939818
36MP0009333_abnormal_splenocyte_physiolog1.87834313
37MP0003567_abnormal_fetal_cardiomyocyte1.87349080
38* MP0001666_abnormal_nutrient_absorption1.83929534
39MP0004145_abnormal_muscle_electrophysio1.83048420
40MP0002970_abnormal_white_adipose1.82496540
41* MP0001944_abnormal_pancreas_morphology1.82384851
42MP0009115_abnormal_fat_cell1.79199969
43MP0005085_abnormal_gallbladder_physiolo1.76062651
44MP0008961_abnormal_basal_metabolism1.74538507
45MP0004924_abnormal_behavior1.73720295
46MP0005386_behavior/neurological_phenoty1.73720295
47MP0003303_peritoneal_inflammation1.72757660
48* MP0000490_abnormal_crypts_of1.71962835
49MP0003121_genomic_imprinting1.63485926
50MP0004133_heterotaxia1.60418397
51MP0002653_abnormal_ependyma_morphology1.58830605
52MP0003300_gastrointestinal_ulcer1.57898467
53MP0002928_abnormal_bile_duct1.57849181
54MP0002277_abnormal_respiratory_mucosa1.57187033
55MP0002396_abnormal_hematopoietic_system1.53141879
56MP0002557_abnormal_social/conspecific_i1.53107807
57MP0005389_reproductive_system_phenotype1.53014073
58MP0002089_abnormal_postnatal_growth/wei1.52328887
59MP0003385_abnormal_body_wall1.48706682
60MP0004272_abnormal_basement_membrane1.47381245
61MP0004197_abnormal_fetal_growth/weight/1.46572556
62MP0009780_abnormal_chondrocyte_physiolo1.42452502
63MP0003115_abnormal_respiratory_system1.41027911
64MP0000427_abnormal_hair_cycle1.36709189
65MP0004185_abnormal_adipocyte_glucose1.36458873
66MP0002938_white_spotting1.36229316
67MP0002098_abnormal_vibrissa_morphology1.35832899
68MP0005076_abnormal_cell_differentiation1.35464798
69MP0001970_abnormal_pain_threshold1.35156978
70MP0002067_abnormal_sensory_capabilities1.30457817
71MP0003705_abnormal_hypodermis_morpholog1.28972966
72MP0003787_abnormal_imprinting1.28399940
73MP0001853_heart_inflammation1.27497714
74MP0001486_abnormal_startle_reflex1.23804002
75MP0005375_adipose_tissue_phenotype1.23250184
76MP0009046_muscle_twitch1.23228422
77MP0003646_muscle_fatigue1.23170750
78* MP0003866_abnormal_defecation1.22173696
79MP0003566_abnormal_cell_adhesion1.22024490
80MP0005397_hematopoietic_system_phenotyp1.21721716
81MP0001545_abnormal_hematopoietic_system1.21721716
82MP0005408_hypopigmentation1.19477654
83* MP0009672_abnormal_birth_weight1.19369460
84MP0005501_abnormal_skin_physiology1.18505156
85* MP0005452_abnormal_adipose_tissue1.18010957
86MP0002069_abnormal_eating/drinking_beha1.17084422
87MP0002160_abnormal_reproductive_system1.15726206
88MP0005535_abnormal_body_temperature1.15314712
89* MP0002693_abnormal_pancreas_physiology1.15091241
90MP0001663_abnormal_digestive_system1.14963644
91MP0003111_abnormal_nucleus_morphology1.13538766
92MP0000604_amyloidosis1.13513517
93MP0006276_abnormal_autonomic_nervous1.13451843
94MP0009384_cardiac_valve_regurgitation1.09998067
95MP0003329_amyloid_beta_deposits1.09389800
96* MP0003953_abnormal_hormone_level1.08552544
97MP0002896_abnormal_bone_mineralization1.08552079
98MP0002063_abnormal_learning/memory/cond1.07518558
99* MP0001664_abnormal_digestion1.07404282
100MP0009745_abnormal_behavioral_response1.07055214
101MP0002282_abnormal_trachea_morphology1.07020838
102MP0001849_ear_inflammation1.05014833
103MP0002138_abnormal_hepatobiliary_system1.02915629
104MP0004859_abnormal_synaptic_plasticity1.02849884
105MP0009840_abnormal_foam_cell1.02635737
106MP0002272_abnormal_nervous_system0.99330281
107* MP0002078_abnormal_glucose_homeostasis0.99253974
108MP0002572_abnormal_emotion/affect_behav0.97776762
109MP0000538_abnormal_urinary_bladder0.97364854
110* MP0002118_abnormal_lipid_homeostasis0.97147285
111MP0002139_abnormal_hepatobiliary_system0.96995437
112MP0000858_altered_metastatic_potential0.96795555
113* MP0010329_abnormal_lipoprotein_level0.96729823
114MP0003942_abnormal_urinary_system0.96608969
115MP0005275_abnormal_skin_tensile0.96527670
116MP0003948_abnormal_gas_homeostasis0.95555877
117MP0000631_abnormal_neuroendocrine_gland0.95144242
118MP0002822_catalepsy0.94940502
119MP0003195_calcinosis0.94255938
120MP0004147_increased_porphyrin_level0.94050547
121* MP0000470_abnormal_stomach_morphology0.93525302
122* MP0000477_abnormal_intestine_morphology0.93481802
123MP0003879_abnormal_hair_cell0.92797520
124MP0005646_abnormal_pituitary_gland0.91431555
125MP0005508_abnormal_skeleton_morphology0.88734707
126MP0003635_abnormal_synaptic_transmissio0.87868240
127MP0010771_integument_phenotype0.86926627
128MP0004019_abnormal_vitamin_homeostasis0.86822275
129* MP0009703_decreased_birth_body0.85565145
130MP0005365_abnormal_bile_salt0.85563291
131MP0000613_abnormal_salivary_gland0.83185179
132MP0008775_abnormal_heart_ventricle0.81681793
133MP0002064_seizures0.81523558
134MP0010678_abnormal_skin_adnexa0.80119119
135MP0003861_abnormal_nervous_system0.78114689
136MP0008438_abnormal_cutaneous_collagen0.77123424
137MP0001216_abnormal_epidermal_layer0.73190164
138MP0001730_embryonic_growth_arrest0.72540801
139MP0003453_abnormal_keratinocyte_physiol0.71527295
140MP0008995_early_reproductive_senescence0.71475810
141MP0001968_abnormal_touch/_nociception0.69710567
142MP0002736_abnormal_nociception_after0.68340762
143* MP0005334_abnormal_fat_pad0.66950421
144MP0002060_abnormal_skin_morphology0.66583922
145MP0000013_abnormal_adipose_tissue0.66566423
146MP0000350_abnormal_cell_proliferation0.66068391
147MP0000467_abnormal_esophagus_morphology0.65803179
148MP0002751_abnormal_autonomic_nervous0.64958676
149MP0003890_abnormal_embryonic-extraembry0.64547544
150MP0005499_abnormal_olfactory_system0.64043261
151MP0005394_taste/olfaction_phenotype0.64043261
152MP0004858_abnormal_nervous_system0.62731522
153MP0004742_abnormal_vestibular_system0.62654061
154MP0000566_synostosis0.62569680
155MP0006138_congestive_heart_failure0.62447875
156MP0001727_abnormal_embryo_implantation0.60755350
157MP0002152_abnormal_brain_morphology0.60672924
158MP0002111_abnormal_tail_morphology0.60504122
159MP0001502_abnormal_circadian_rhythm0.60460342
160* MP0010155_abnormal_intestine_physiology0.57632020
161MP0000762_abnormal_tongue_morphology0.56697151
162MP0004134_abnormal_chest_morphology0.55764693
163MP0005381_digestive/alimentary_phenotyp0.55245701
164* MP0003959_abnormal_lean_body0.55173057
165MP0000647_abnormal_sebaceous_gland0.54361941
166MP0000579_abnormal_nail_morphology0.53892839
167MP0003806_abnormal_nucleotide_metabolis0.53514979
168MP0004782_abnormal_surfactant_physiolog0.53474921
169MP0009379_abnormal_foot_pigmentation0.53425373
170MP0002090_abnormal_vision0.53091174
171MP0002086_abnormal_extraembryonic_tissu0.52922141
172MP0001286_abnormal_eye_development0.51453430
173MP0004808_abnormal_hematopoietic_stem0.51328780
174MP0002249_abnormal_larynx_morphology0.49937588
175MP0001340_abnormal_eyelid_morphology0.49793313
176MP0003638_abnormal_response/metabolism_0.48471330
177MP0002909_abnormal_adrenal_gland0.44517536
178MP0001270_distended_abdomen0.44070159

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)9.14214329
2Abnormal hair laboratory examination (HP:0003328)8.52489743
3Abnormal respiratory epithelium morphology (HP:0012253)5.80832268
4Abnormal respiratory motile cilium morphology (HP:0005938)5.80832268
5Protruding tongue (HP:0010808)5.73516886
6Hyperventilation (HP:0002883)5.53722443
7Clumsiness (HP:0002312)5.33303763
8Chronic sinusitis (HP:0011109)5.08200012
9Pili torti (HP:0003777)4.86356894
10Enlarged penis (HP:0000040)4.62065209
11Curly hair (HP:0002212)4.52395343
12Hypoplastic pelvis (HP:0008839)4.45996604
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.42797200
14Abnormality of alanine metabolism (HP:0010916)4.42797200
15Hyperalaninemia (HP:0003348)4.42797200
16Abnormality of the fingertips (HP:0001211)4.38168354
17Recurrent sinusitis (HP:0011108)4.37514833
18Ankyloglossia (HP:0010296)4.20629337
19Abnormality of endocrine pancreas physiology (HP:0012093)4.10659220
20Abnormality of the pancreatic islet cells (HP:0006476)4.10659220
21Genetic anticipation (HP:0003743)3.89479811
22Micronodular cirrhosis (HP:0001413)3.81493515
23Broad-based gait (HP:0002136)3.54746620
24Ulnar bowing (HP:0003031)3.49153955
25Late onset (HP:0003584)3.40938305
26Abnormality of small intestinal villus morphology (HP:0011472)3.34980312
27Villous atrophy (HP:0011473)3.34980312
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.31429963
29Fragile skin (HP:0001030)3.30811226
30Abnormality of oral frenula (HP:0000190)3.27546633
31Gonadotropin excess (HP:0000837)3.22262433
32Brittle hair (HP:0002299)3.15618430
33Infantile muscular hypotonia (HP:0008947)3.14593416
34Ketoacidosis (HP:0001993)3.06935823
35Thrombocytosis (HP:0001894)3.06665531
36Atrophic scars (HP:0001075)3.04925173
37Exotropia (HP:0000577)2.93213619
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.93107250
39Birth length less than 3rd percentile (HP:0003561)2.91989375
40Obstructive sleep apnea (HP:0002870)2.89676101
41Hepatoblastoma (HP:0002884)2.86611583
42Increased cerebral lipofuscin (HP:0011813)2.86602186
43Abnormalities of placenta or umbilical cord (HP:0001194)2.86362096
44Right ventricular cardiomyopathy (HP:0011663)2.84747708
45Shawl scrotum (HP:0000049)2.83946761
46Drooling (HP:0002307)2.82073459
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.78731248
48Global brain atrophy (HP:0002283)2.77736188
49Milia (HP:0001056)2.76333598
50Abnormal pancreas size (HP:0012094)2.72242168
51Precocious puberty (HP:0000826)2.71275087
52Breast hypoplasia (HP:0003187)2.69106663
53Urethral obstruction (HP:0000796)2.68978238
54Periodontitis (HP:0000704)2.67748904
55Visual hallucinations (HP:0002367)2.66480398
56Aplastic anemia (HP:0001915)2.65597768
57Acute lymphatic leukemia (HP:0006721)2.64940691
58Radial bowing (HP:0002986)2.64161927
59Hypercortisolism (HP:0001578)2.63999746
60Spastic tetraparesis (HP:0001285)2.63786874
61Excessive salivation (HP:0003781)2.62881918
62Neoplasm of the oral cavity (HP:0100649)2.59769559
63Concave nail (HP:0001598)2.58872022
64Impaired smooth pursuit (HP:0007772)2.55902328
65Ovarian neoplasm (HP:0100615)2.55616343
66Nephroblastoma (Wilms tumor) (HP:0002667)2.54166172
67Renovascular hypertension (HP:0100817)2.53247154
68Asymmetry of the thorax (HP:0001555)2.52038470
69Woolly hair (HP:0002224)2.50597231
70Flat occiput (HP:0005469)2.49784054
71Impulsivity (HP:0100710)2.45218743
72Hyperinsulinemic hypoglycemia (HP:0000825)2.44170325
73Germ cell neoplasia (HP:0100728)2.42391178
74Pancreatic islet-cell hyperplasia (HP:0004510)2.40735557
75Subacute progressive viral hepatitis (HP:0006572)2.40067202
76Severe Myopia (HP:0011003)2.36190723
77Pendular nystagmus (HP:0012043)2.36178105
78Cerebral aneurysm (HP:0004944)2.34526957
79Lymphangioma (HP:0100764)2.34143841
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33940723
81Neoplasm of the heart (HP:0100544)2.32951235
82Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.31949017
83Patellar aplasia (HP:0006443)2.30997807
84Hyperparathyroidism (HP:0000843)2.30580592
85Embryonal renal neoplasm (HP:0011794)2.28277693
86Hemorrhage of the eye (HP:0011885)2.28000214
87Increased density of long bones (HP:0006392)2.27042732
88Dysdiadochokinesis (HP:0002075)2.26447515
89Diplopia (HP:0000651)2.26433723
90Abnormality of binocular vision (HP:0011514)2.26433723
91Progressive cerebellar ataxia (HP:0002073)2.25224158
92Rectal prolapse (HP:0002035)2.24906480
93Atonic seizures (HP:0010819)2.24672118
94Congenital stationary night blindness (HP:0007642)2.24656893
95Esophageal varix (HP:0002040)2.23884090
96Lack of skin elasticity (HP:0100679)2.21791603
97Hyperacusis (HP:0010780)2.21739420
98Metaphyseal cupping (HP:0003021)2.21300022
99Abnormal platelet volume (HP:0011876)2.20413645
100Aplasia/Hypoplasia of the patella (HP:0006498)2.19856627
101Abnormality of the aortic arch (HP:0012303)2.19221670
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14555613
103Short 4th metacarpal (HP:0010044)2.14555613
104Tented upper lip vermilion (HP:0010804)2.14125704
105Distal lower limb amyotrophy (HP:0008944)2.11461008
106Biliary tract neoplasm (HP:0100574)2.11394466
107Diastasis recti (HP:0001540)2.08703489
108Thin bony cortex (HP:0002753)2.08007216
109Abnormality of methionine metabolism (HP:0010901)2.05280500
110Deformed sella turcica (HP:0002681)2.03805077
111Renal cortical cysts (HP:0000803)2.03612426
112Abnormality of the gastric mucosa (HP:0004295)2.02470550
113Nasal polyposis (HP:0100582)2.01857113
114Inappropriate behavior (HP:0000719)2.00391131
115Hypochromic anemia (HP:0001931)1.98515515
116Skull defect (HP:0001362)1.97855027
117Exocrine pancreatic insufficiency (HP:0001738)1.96838750
118Abnormal umbilical cord blood vessels (HP:0011403)1.95598864
119Single umbilical artery (HP:0001195)1.95598864
120Abnormality of the fetal cardiovascular system (HP:0010948)1.95598864
121Intellectual disability, progressive (HP:0006887)1.95065042
122Hemiplegia (HP:0002301)1.94901889
123Uterine neoplasm (HP:0010784)1.93684321
124Intellectual disability, severe (HP:0010864)1.92033390
125Gastroesophageal reflux (HP:0002020)1.91971725
126Insulin resistance (HP:0000855)1.91317796
127Decreased subcutaneous fat (HP:0001002)1.91289350
128Congenital sensorineural hearing impairment (HP:0008527)1.90907092
129Neoplasm of the small intestine (HP:0100833)1.89919810
130Abnormality of the tricuspid valve (HP:0001702)1.89783591
131Hypoalbuminemia (HP:0003073)1.88950973
132Abnormal albumin level (HP:0012116)1.88950973
133Fragile nails (HP:0001808)1.88557071
134Enlarged kidneys (HP:0000105)1.88132310
135Intellectual disability, profound (HP:0002187)1.87695255
136Colon cancer (HP:0003003)1.87444430
137Breast carcinoma (HP:0003002)1.86536827
138Abnormality of dentin (HP:0010299)1.86444182
139Hypergonadotropic hypogonadism (HP:0000815)1.86421551
140Malignant gastrointestinal tract tumors (HP:0006749)1.86311854
141Gastrointestinal carcinoma (HP:0002672)1.86311854
142Striae distensae (HP:0001065)1.85738017
143Impaired social interactions (HP:0000735)1.85431408
144Abnormal social behavior (HP:0012433)1.85431408
145Abnormality of the 4th metacarpal (HP:0010012)1.85398828
146Onycholysis (HP:0001806)1.84654018
147Adactyly (HP:0009776)1.84098386
148Truncal obesity (HP:0001956)1.83243406
149Bowing of the arm (HP:0006488)1.82262202
150Bowed forearm bones (HP:0003956)1.82262202
151Abnormality of the incisor (HP:0000676)1.82195042
152Down-sloping shoulders (HP:0200021)1.81923549
153Increased mean platelet volume (HP:0011877)1.81433538
154Intestinal polyp (HP:0005266)1.81293585
155Petechiae (HP:0000967)1.80372850
156Long eyelashes (HP:0000527)1.80371998
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79577662
158Vertebral hypoplasia (HP:0008417)1.79577662
159Hypoplastic ischia (HP:0003175)1.79442775
160Spastic diplegia (HP:0001264)1.79081736
161Trismus (HP:0000211)1.79006887
162Hypoventilation (HP:0002791)1.77431954
163Limb hypertonia (HP:0002509)1.76946288
164Gastrointestinal infarctions (HP:0005244)1.76407562
165Abnormality of the columella (HP:0009929)1.76372126
166Abnormal vertebral ossification (HP:0100569)1.76056137
167Abnormality of the nasal mucosa (HP:0000433)1.75495155
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75139257
169Poor eye contact (HP:0000817)1.74446159
170Hypophosphatemic rickets (HP:0004912)1.73993479
171Eczematoid dermatitis (HP:0000976)1.73982933
172Hypertriglyceridemia (HP:0002155)1.73586464
173Ventricular tachycardia (HP:0004756)1.72369162
174Absent speech (HP:0001344)1.72097644
175Fair hair (HP:0002286)1.71582201
176High pitched voice (HP:0001620)1.71523280
177Gaze-evoked nystagmus (HP:0000640)1.71053670
178Macroorchidism (HP:0000053)1.70175808
179Amniotic constriction ring (HP:0009775)1.69360480
180Abnormality of placental membranes (HP:0011409)1.69360480
181Abnormality of ocular smooth pursuit (HP:0000617)1.69170142
182Abnormality of salivation (HP:0100755)1.68976533
183Neoplasm of the pancreas (HP:0002894)1.68736554
184Gout (HP:0001997)1.68716055
185Short phalanx of the thumb (HP:0009660)1.68620701
186Sporadic (HP:0003745)1.68615919
187Frequent falls (HP:0002359)1.68265979
188Premature loss of primary teeth (HP:0006323)1.67826583
189Abnormality of the intervertebral disk (HP:0005108)1.67731594
190Difficulty walking (HP:0002355)1.67540604
191Type II lissencephaly (HP:0007260)1.67471521
192Unilateral renal agenesis (HP:0000122)1.66908416
193Megalocornea (HP:0000485)1.63163107
194Hemiparesis (HP:0001269)1.60728996
195Scrotal hypoplasia (HP:0000046)1.60227449
196Abnormality of incisor morphology (HP:0011063)1.59391724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.51705687
2CASK6.20054257
3ICK4.29732529
4EPHA24.06164912
5TRIB33.87908938
6PKN23.75937344
7PASK3.03244459
8FGFR42.89473334
9PTK62.83233066
10MAP3K122.71838192
11CAMK1D2.55055530
12FER2.39697673
13SIK12.33526678
14PAK42.32348491
15NTRK22.28495557
16PDGFRA2.28452597
17PLK42.05634582
18PIK3CG2.03625737
19TYRO32.03468127
20EPHB22.01577383
21CAMK1G1.98922072
22BCR1.96634791
23MAP2K61.94260617
24BRD41.90274439
25RIPK41.88192579
26RPS6KB21.85330080
27TAOK21.80051969
28PTK21.78364448
29FGFR21.78319691
30CSF1R1.63648739
31LRRK21.62799788
32GRK11.60017492
33RET1.50843134
34WNK11.49074882
35MAP3K101.44413173
36MAP3K111.43973153
37HIPK21.42872289
38STK111.34371758
39EPHA31.34046848
40MAPK151.31307818
41NTRK11.30055308
42RPS6KA61.28685705
43SIK21.27751479
44UHMK11.22951193
45CDC42BPA1.22491388
46CAMK41.21819459
47CDK121.21565201
48RPS6KA21.17459742
49CDK191.16820765
50EPHB11.16103106
51FRK1.15713708
52PDGFRB1.15621080
53MAP3K131.15429897
54PRPF4B1.15402830
55RPS6KC11.15062022
56RPS6KL11.15062022
57TLK11.14048339
58MAP3K51.13505019
59EEF2K1.12480268
60KIT1.12159520
61MAP2K21.12086902
62DDR21.11571449
63CAMKK11.10160649
64MELK1.02844394
65FGFR11.01835507
66SIK31.01239238
67TNK20.98647013
68CSK0.96661224
69MARK20.94014360
70DYRK1B0.92827741
71MAP3K10.87788974
72IRAK30.85482435
73MAP3K80.81256609
74PDPK10.80879809
75SGK20.79004148
76PRKAA20.78758397
77LATS10.78572134
78DAPK20.75567254
79NEK90.72822151
80STK390.72800739
81IRAK40.72758800
82PRKD20.72248753
83MARK10.70789352
84IRAK10.70336982
85PAK20.69735953
86TTK0.66814881
87MATK0.64464464
88CDK40.63765065
89RPS6KB10.62357639
90PRKAA10.62158061
91PDK10.60715679
92CDK80.59250861
93PAK30.58676979
94SRC0.57702926
95RIPK10.57275623
96PRKCH0.57017591
97MTOR0.55961032
98LATS20.55906298
99ILK0.55796321
100MAP4K10.54751876
101TAOK10.52978155
102PRKCI0.52736662
103PBK0.51460194
104MET0.51235844
105NME20.50755304
106CHUK0.50606173
107DAPK10.50373760
108RPS6KA50.50246664
109CDK70.49618734
110FGFR30.46854871
111NEK20.46793109
112FLT30.44223591
113SGK2230.44060477
114SGK4940.44060477
115LYN0.42521971
116ATR0.42402223
117MAPK120.41987556
118DYRK30.41663269
119RPS6KA40.40162892
120FYN0.39928999
121MAP3K70.39519829
122ERBB20.39295953
123CDK60.36038170
124RPS6KA10.35947344
125CAMK10.35700225
126HCK0.35500896
127ROCK20.35434448
128SGK30.35362840
129PRKD30.35238948
130MAP3K20.34317931
131OXSR10.34251276
132LMTK20.33544860
133AURKB0.32873274
134DAPK30.32828405
135CDC70.32114211
136MST1R0.32096525
137MAP2K10.31974980
138ERN10.30276091
139PKN10.30049281
140GSK3B0.28923902
141TSSK60.28803781
142PRKCE0.28636102
143NTRK30.28458507
144PRKD10.28058792
145IRAK20.27804249
146SMG10.27451941
147CDK90.27084120
148CDK10.26606548
149AKT10.26481467
150MAPK80.26330074
151RPS6KA30.26178573
152BTK0.25909049
153PRKG20.25397187
154CHEK20.24482700
155SGK10.22959146
156PRKCZ0.22391068
157CAMK2B0.22168066
158MUSK0.22012786
159PRKDC0.21733244
160AURKA0.21020216
161MKNK10.20257336
162WNK40.19190790
163CSNK1D0.19112682
164ALK0.18646542
165MAPKAPK20.17737544
166INSR0.17633268

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049508.48581298
2Fatty acid biosynthesis_Homo sapiens_hsa000614.65006037
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.62650390
4Fatty acid metabolism_Homo sapiens_hsa012123.19067592
5Pancreatic secretion_Homo sapiens_hsa049723.09558287
6PPAR signaling pathway_Homo sapiens_hsa033202.90987244
7Fat digestion and absorption_Homo sapiens_hsa049752.64718678
8Protein digestion and absorption_Homo sapiens_hsa049742.63441716
9Butanoate metabolism_Homo sapiens_hsa006502.57033847
10Nicotine addiction_Homo sapiens_hsa050332.54292054
11Fatty acid elongation_Homo sapiens_hsa000622.22772762
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.22557708
13Vibrio cholerae infection_Homo sapiens_hsa051102.13989965
14Notch signaling pathway_Homo sapiens_hsa043302.11945197
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93702916
16Selenocompound metabolism_Homo sapiens_hsa004501.78221010
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74795299
18Taste transduction_Homo sapiens_hsa047421.74700602
19Hedgehog signaling pathway_Homo sapiens_hsa043401.70288568
20Pyruvate metabolism_Homo sapiens_hsa006201.67521181
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.63012808
22AMPK signaling pathway_Homo sapiens_hsa041521.62216460
23Tight junction_Homo sapiens_hsa045301.57632105
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56313269
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52382086
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.50444249
27Basal cell carcinoma_Homo sapiens_hsa052171.46017016
28Sulfur relay system_Homo sapiens_hsa041221.40817758
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.39999521
30Mismatch repair_Homo sapiens_hsa034301.38768465
31Adherens junction_Homo sapiens_hsa045201.38014314
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.36784225
33Non-homologous end-joining_Homo sapiens_hsa034501.35499863
34Glycerolipid metabolism_Homo sapiens_hsa005611.35234492
35Propanoate metabolism_Homo sapiens_hsa006401.35139055
36Steroid biosynthesis_Homo sapiens_hsa001001.30577008
37Ovarian steroidogenesis_Homo sapiens_hsa049131.30473689
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30381335
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28608334
40ABC transporters_Homo sapiens_hsa020101.27893272
41Bile secretion_Homo sapiens_hsa049761.24404001
42RNA polymerase_Homo sapiens_hsa030201.19576075
43Tryptophan metabolism_Homo sapiens_hsa003801.19374931
44Axon guidance_Homo sapiens_hsa043601.18796323
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15741716
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13779303
47Insulin secretion_Homo sapiens_hsa049111.13394816
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13270123
49Bladder cancer_Homo sapiens_hsa052191.12916780
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12697107
51N-Glycan biosynthesis_Homo sapiens_hsa005101.09741331
52Collecting duct acid secretion_Homo sapiens_hsa049661.09678042
53Prion diseases_Homo sapiens_hsa050201.03469013
54Hippo signaling pathway_Homo sapiens_hsa043901.01991343
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01283807
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01043842
57Calcium signaling pathway_Homo sapiens_hsa040201.00042430
58Proteoglycans in cancer_Homo sapiens_hsa052050.99988352
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96190889
60Thyroid cancer_Homo sapiens_hsa052160.96143781
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95842618
62Insulin signaling pathway_Homo sapiens_hsa049100.95616025
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94858410
64Ribosome_Homo sapiens_hsa030100.94844620
65Arginine and proline metabolism_Homo sapiens_hsa003300.94601055
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.94528121
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93354890
68ECM-receptor interaction_Homo sapiens_hsa045120.91222132
69Renin-angiotensin system_Homo sapiens_hsa046140.91152164
70Linoleic acid metabolism_Homo sapiens_hsa005910.89701506
71Nitrogen metabolism_Homo sapiens_hsa009100.88379165
72Insulin resistance_Homo sapiens_hsa049310.87528746
73Lysine degradation_Homo sapiens_hsa003100.85051356
74Circadian entrainment_Homo sapiens_hsa047130.82094125
75mTOR signaling pathway_Homo sapiens_hsa041500.82030918
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81928755
77Small cell lung cancer_Homo sapiens_hsa052220.80856029
78MicroRNAs in cancer_Homo sapiens_hsa052060.80430319
79Protein export_Homo sapiens_hsa030600.79908191
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79460710
81Morphine addiction_Homo sapiens_hsa050320.76753141
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75935515
83Ether lipid metabolism_Homo sapiens_hsa005650.74435520
84Epstein-Barr virus infection_Homo sapiens_hsa051690.72579166
85Rap1 signaling pathway_Homo sapiens_hsa040150.70875534
86Estrogen signaling pathway_Homo sapiens_hsa049150.70485115
87VEGF signaling pathway_Homo sapiens_hsa043700.70322357
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68412963
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.68307459
90Fatty acid degradation_Homo sapiens_hsa000710.67337599
91Amoebiasis_Homo sapiens_hsa051460.66908022
92Chronic myeloid leukemia_Homo sapiens_hsa052200.66695195
93Histidine metabolism_Homo sapiens_hsa003400.65972868
94Antigen processing and presentation_Homo sapiens_hsa046120.65505001
95GABAergic synapse_Homo sapiens_hsa047270.65390411
96Focal adhesion_Homo sapiens_hsa045100.65173011
97Melanoma_Homo sapiens_hsa052180.65102049
98Colorectal cancer_Homo sapiens_hsa052100.64762490
99Pertussis_Homo sapiens_hsa051330.63513871
100Synaptic vesicle cycle_Homo sapiens_hsa047210.63440335
101Acute myeloid leukemia_Homo sapiens_hsa052210.62784154
102Dorso-ventral axis formation_Homo sapiens_hsa043200.62528182
103Gastric acid secretion_Homo sapiens_hsa049710.61965344
104Phototransduction_Homo sapiens_hsa047440.61519044
105Proteasome_Homo sapiens_hsa030500.61331238
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61098413
107Toxoplasmosis_Homo sapiens_hsa051450.60305037
108Amphetamine addiction_Homo sapiens_hsa050310.60061896
109Arginine biosynthesis_Homo sapiens_hsa002200.59486677
110Shigellosis_Homo sapiens_hsa051310.57681991
111Cell cycle_Homo sapiens_hsa041100.57573014
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57440854
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56794272
114Endometrial cancer_Homo sapiens_hsa052130.56671017
115p53 signaling pathway_Homo sapiens_hsa041150.55160631
116Spliceosome_Homo sapiens_hsa030400.53597880
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51457329
118Cocaine addiction_Homo sapiens_hsa050300.51149945
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51025048
120Viral myocarditis_Homo sapiens_hsa054160.50915418
121TGF-beta signaling pathway_Homo sapiens_hsa043500.50495465
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.50304887
123Thyroid hormone synthesis_Homo sapiens_hsa049180.50222577
124Sulfur metabolism_Homo sapiens_hsa009200.49969114
125Glutamatergic synapse_Homo sapiens_hsa047240.49845536
126Retinol metabolism_Homo sapiens_hsa008300.48598201
127Glucagon signaling pathway_Homo sapiens_hsa049220.48423419
128Homologous recombination_Homo sapiens_hsa034400.48181128
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.47539249
130Pathways in cancer_Homo sapiens_hsa052000.47496466
131Viral carcinogenesis_Homo sapiens_hsa052030.45971517
132Phenylalanine metabolism_Homo sapiens_hsa003600.45680608
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45626789
134Wnt signaling pathway_Homo sapiens_hsa043100.45104514
135Serotonergic synapse_Homo sapiens_hsa047260.45006930
136cAMP signaling pathway_Homo sapiens_hsa040240.44738956
137Glioma_Homo sapiens_hsa052140.44422857
138Type II diabetes mellitus_Homo sapiens_hsa049300.44378901
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43067451
140Prolactin signaling pathway_Homo sapiens_hsa049170.42788931
141Fanconi anemia pathway_Homo sapiens_hsa034600.42083853
142Melanogenesis_Homo sapiens_hsa049160.41750215
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41240244
144ErbB signaling pathway_Homo sapiens_hsa040120.40828616
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39390629
146beta-Alanine metabolism_Homo sapiens_hsa004100.39176173
147Platelet activation_Homo sapiens_hsa046110.38965426
148Salivary secretion_Homo sapiens_hsa049700.38052421
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37671856
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.36933611
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36628394
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36424649
153Salmonella infection_Homo sapiens_hsa051320.36226469
154Hepatitis C_Homo sapiens_hsa051600.36051724
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32657376
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32530118
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32252503
158Dopaminergic synapse_Homo sapiens_hsa047280.30143665
159Cholinergic synapse_Homo sapiens_hsa047250.28926780
160Prostate cancer_Homo sapiens_hsa052150.27647205
161Pancreatic cancer_Homo sapiens_hsa052120.27341465
162Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26987890
163Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26857610
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25585903
165Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25386105
166Tyrosine metabolism_Homo sapiens_hsa003500.25322717
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24970870
168Ras signaling pathway_Homo sapiens_hsa040140.24873043

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