NEUROG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)8.25112954
2dopaminergic neuron differentiation (GO:0071542)7.67990399
3lateral sprouting from an epithelium (GO:0060601)7.43872334
4negative regulation of epidermal cell differentiation (GO:0045605)6.31031873
5positive regulation of neuroblast proliferation (GO:0002052)5.87314499
6limb bud formation (GO:0060174)5.87299800
7axonal fasciculation (GO:0007413)5.63094112
8axon ensheathment in central nervous system (GO:0032291)5.46986523
9central nervous system myelination (GO:0022010)5.46986523
10nephron tubule development (GO:0072080)5.43541651
11planar cell polarity pathway involved in neural tube closure (GO:0090179)5.29578243
12glial cell proliferation (GO:0014009)5.23476565
13respiratory tube development (GO:0030323)5.17494749
14negative regulation of epidermis development (GO:0045683)5.14095582
15negative regulation of interleukin-10 production (GO:0032693)5.12138850
16left/right axis specification (GO:0070986)5.07269253
17layer formation in cerebral cortex (GO:0021819)5.04855971
18neuron fate determination (GO:0048664)5.03441178
19pyrimidine nucleobase catabolic process (GO:0006208)4.92235393
20renal tubule development (GO:0061326)4.89929184
21epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.85368376
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.78494702
23positive regulation of neural precursor cell proliferation (GO:2000179)4.75284230
24negative regulation of oligodendrocyte differentiation (GO:0048715)4.67156476
25kidney morphogenesis (GO:0060993)4.62100771
26lung vasculature development (GO:0060426)4.61520531
27cerebral cortex neuron differentiation (GO:0021895)4.59318953
28spinal cord development (GO:0021510)4.57011034
29lung morphogenesis (GO:0060425)4.56602158
30skeletal muscle organ development (GO:0060538)4.53351672
31convergent extension (GO:0060026)4.45733012
32midgut development (GO:0007494)4.43642707
33establishment of monopolar cell polarity (GO:0061162)4.42465710
34establishment or maintenance of monopolar cell polarity (GO:0061339)4.42465710
35negative regulation of axon guidance (GO:1902668)4.33671793
36cardiac ventricle formation (GO:0003211)4.33520804
37paraxial mesoderm development (GO:0048339)4.31898115
38nephron epithelium development (GO:0072009)4.30184621
39establishment of planar polarity (GO:0001736)4.27164736
40establishment of tissue polarity (GO:0007164)4.27164736
41neuron recognition (GO:0008038)4.25342808
42diaphragm development (GO:0060539)4.25326348
43Notch signaling involved in heart development (GO:0061314)4.24874702
44substrate-independent telencephalic tangential migration (GO:0021826)4.15663483
45substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.15663483
46segment specification (GO:0007379)4.10423809
47viral transcription (GO:0019083)4.05789931
48dendritic spine morphogenesis (GO:0060997)4.03933602
49behavioral response to nicotine (GO:0035095)4.03379914
50translational termination (GO:0006415)3.95188565
51axon extension involved in axon guidance (GO:0048846)3.93988607
52neuron projection extension involved in neuron projection guidance (GO:1902284)3.93988607
53glomerulus development (GO:0032835)3.90625120
54Notch receptor processing (GO:0007220)3.89140389
55cardiac chamber formation (GO:0003207)3.87129210
56regulation of neuroblast proliferation (GO:1902692)3.86661086
57epithelial cell differentiation involved in prostate gland development (GO:0060742)3.85789779
58embryonic retina morphogenesis in camera-type eye (GO:0060059)3.85684113
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.85321354
60bone trabecula formation (GO:0060346)3.85228390
61cell migration in hindbrain (GO:0021535)3.80820831
62endocardial cushion morphogenesis (GO:0003203)3.76450106
63forebrain neuron differentiation (GO:0021879)3.75952660
64sequestering of actin monomers (GO:0042989)3.75077969
65presynaptic membrane assembly (GO:0097105)3.72786976
66sympathetic nervous system development (GO:0048485)3.69686995
67ventricular trabecula myocardium morphogenesis (GO:0003222)3.68188554
68cell proliferation in forebrain (GO:0021846)3.66660439
69DNA topological change (GO:0006265)3.66070394
70nucleobase catabolic process (GO:0046113)3.65484291
71positive regulation of Notch signaling pathway (GO:0045747)3.63552633
72atrial septum morphogenesis (GO:0060413)3.60472732
73establishment of apical/basal cell polarity (GO:0035089)3.60337502
74presynaptic membrane organization (GO:0097090)3.58634644
75cell differentiation involved in metanephros development (GO:0072202)3.58132420
76apical protein localization (GO:0045176)3.57795053
77heart valve formation (GO:0003188)3.57765946
78polarized epithelial cell differentiation (GO:0030859)3.57718722
79positive regulation of gastrulation (GO:2000543)3.56353517
80neuron fate specification (GO:0048665)3.53332511
81regulation of somitogenesis (GO:0014807)3.48896239
82ventricular septum morphogenesis (GO:0060412)3.47264156
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.45815623
84mesenchymal cell differentiation involved in kidney development (GO:0072161)3.44874384
85mesenchymal cell differentiation involved in renal system development (GO:2001012)3.44874384
86midbrain development (GO:0030901)3.44699453
87cerebral cortex radially oriented cell migration (GO:0021799)3.44518414
88regulation of protein heterodimerization activity (GO:0043497)3.42853389
89regulation of astrocyte differentiation (GO:0048710)3.42751385
90establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.42324828
91face development (GO:0060324)3.40692868
92type B pancreatic cell development (GO:0003323)3.40153780
93central nervous system projection neuron axonogenesis (GO:0021952)3.40117665
94cochlea morphogenesis (GO:0090103)3.32929850
95epithelial cell fate commitment (GO:0072148)3.32181563
96regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.30328390
97retinal ganglion cell axon guidance (GO:0031290)3.27040576
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.26225916
99cartilage morphogenesis (GO:0060536)3.24618698
100positive regulation of dendritic spine morphogenesis (GO:0061003)3.24314217
101cellular protein complex disassembly (GO:0043624)3.23844104
102regulation of axon extension involved in axon guidance (GO:0048841)3.21463167
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21332630
104negative regulation of axon extension (GO:0030517)3.19924374
105cell surface receptor signaling pathway involved in heart development (GO:0061311)3.19807791
106urogenital system development (GO:0001655)3.19291670
107primitive streak formation (GO:0090009)3.18419560
108cotranslational protein targeting to membrane (GO:0006613)3.18114745
109regulation of axon guidance (GO:1902667)3.17507199
110negative regulation of osteoblast proliferation (GO:0033689)3.16349087
111negative regulation of astrocyte differentiation (GO:0048712)3.14977363
112dentate gyrus development (GO:0021542)3.14361091
113Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.12949599
114embryonic foregut morphogenesis (GO:0048617)3.11962443
115heart trabecula morphogenesis (GO:0061384)3.11881325
116hindbrain development (GO:0030902)3.11011540
117protein targeting to ER (GO:0045047)3.10680926
118central nervous system neuron axonogenesis (GO:0021955)3.09629826
119establishment of nucleus localization (GO:0040023)3.09557337
120postsynaptic membrane organization (GO:0001941)3.09107123
121negative regulation of glial cell differentiation (GO:0045686)3.06532203
122regulation of oligodendrocyte differentiation (GO:0048713)3.04636230
123cell differentiation involved in kidney development (GO:0061005)3.04361639
124translational elongation (GO:0006414)3.02467685
125heparin biosynthetic process (GO:0030210)3.01847001
126heparin metabolic process (GO:0030202)3.01847001
127regulation of development, heterochronic (GO:0040034)3.01736077
128olfactory bulb development (GO:0021772)3.01581606
129peristalsis (GO:0030432)3.00643072
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.99306540
131establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98533306
132cell fate determination (GO:0001709)2.98186160
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97894531
134collecting duct development (GO:0072044)2.97395984
135extracellular fibril organization (GO:0043206)2.93962536
136protein complex disassembly (GO:0043241)2.93019742
137auditory behavior (GO:0031223)2.91658968
138regulation of establishment of planar polarity (GO:0090175)2.91273906
139endocardial cushion development (GO:0003197)2.90873415
140negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89002258
141regulation of timing of cell differentiation (GO:0048505)2.85887553
142protein localization to endoplasmic reticulum (GO:0070972)2.85876982
143ganglion development (GO:0061548)2.85701884
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85244983
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.84402687
146regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.84046374
147negative regulation of catenin import into nucleus (GO:0035414)2.83900727
148lung-associated mesenchyme development (GO:0060484)2.83762292
149cranial nerve morphogenesis (GO:0021602)2.83201232
150embryonic pattern specification (GO:0009880)2.82645382
151nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80245675
152macromolecular complex disassembly (GO:0032984)2.79642511
153viral life cycle (GO:0019058)2.79083920
154negative chemotaxis (GO:0050919)2.75895557
155axon extension (GO:0048675)2.75759690
156somite development (GO:0061053)2.73096804
157regulation of smooth muscle cell differentiation (GO:0051150)2.71827943
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67333892
159embryonic digestive tract morphogenesis (GO:0048557)2.67245579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_27304074_Chip-Seq_ESCs_Mouse3.88304499
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.47542648
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.27875127
4* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.12779099
5* CBX2_27304074_Chip-Seq_ESCs_Mouse3.12223255
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11666462
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06772657
8* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.04130391
9EZH2_22144423_ChIP-Seq_EOC_Human3.01610150
10* EED_16625203_ChIP-ChIP_MESCs_Mouse3.00109536
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92350814
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92350814
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.85221245
14* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.71933771
15* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.68571454
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.68341892
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67989547
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.65384111
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61597780
20* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.60449297
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55918376
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.39979136
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35239492
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34762127
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32735641
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31245069
27* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31039917
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27021998
29* RING1B_27294783_Chip-Seq_NPCs_Mouse2.25731484
30* RING1B_27294783_Chip-Seq_ESCs_Mouse2.20487304
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13291056
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10302574
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06172808
34GBX2_23144817_ChIP-Seq_PC3_Human2.06093249
35* TP53_20018659_ChIP-ChIP_R1E_Mouse2.02775034
36* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01336630
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00008229
38* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.98290354
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.95685048
40TP53_18474530_ChIP-ChIP_U2OS_Human1.90694905
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.74016148
42* SOX2_16153702_ChIP-ChIP_HESCs_Human1.72827736
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71230751
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67310462
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66673107
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66298545
47* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65555405
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.63582723
49REST_21632747_ChIP-Seq_MESCs_Mouse1.61621896
50* RNF2_27304074_Chip-Seq_NSC_Mouse1.59432428
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57789215
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55957966
53SMAD4_21799915_ChIP-Seq_A2780_Human1.48718347
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47237266
55EWS_26573619_Chip-Seq_HEK293_Human1.46506470
56* P300_19829295_ChIP-Seq_ESCs_Human1.43111229
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41836983
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40601803
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38267641
60FUS_26573619_Chip-Seq_HEK293_Human1.32571387
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32333295
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32225102
63* KDM2B_26808549_Chip-Seq_K562_Human1.31309897
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30187986
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.29898380
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27029884
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.26931698
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26283335
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.25574293
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24878652
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24143608
72* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23519362
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.22138243
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22106190
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22095986
76SOX9_26525672_Chip-Seq_HEART_Mouse1.21883027
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21660766
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21235362
79SOX3_22085726_ChIP-Seq_NPCs_Mouse1.20948134
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20577564
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20229988
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19555978
83POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19078931
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.18687374
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16833866
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16209658
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15615363
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15573292
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13926843
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.12619790
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12140129
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12079746
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12079746
94ZNF274_21170338_ChIP-Seq_K562_Hela1.11737809
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10578837
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09490270
97* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09457108
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09405198
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.08933478
100IGF1R_20145208_ChIP-Seq_DFB_Human1.08645226
101TP53_16413492_ChIP-PET_HCT116_Human1.08443584
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07321751
103DROSHA_22980978_ChIP-Seq_HELA_Human1.07078610
104AR_25329375_ChIP-Seq_VCAP_Human1.05387775
105* P53_22387025_ChIP-Seq_ESCs_Mouse1.05239512
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04028135
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03605937
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02394864
109POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.02227667
110* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02046680
111IRF1_19129219_ChIP-ChIP_H3396_Human1.02026016
112* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01855531
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01669671
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99039279
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98849989
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98242443
117E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97761464
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97024309
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96876880
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96493015
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96080542
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94763975
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94029290
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93345926
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92645013
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92572604
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92275168
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90710345
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89530332
130CTCF_27219007_Chip-Seq_Bcells_Human0.88690866
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88292163
132TAF15_26573619_Chip-Seq_HEK293_Human0.87495417
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85174167
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81298778
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80385163
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79121635
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.79041484
138AR_21572438_ChIP-Seq_LNCaP_Human0.78979505
139XRN2_22483619_ChIP-Seq_HELA_Human0.78891693
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.78434282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.71505003
2MP0000566_synostosis4.40082436
3MP0006292_abnormal_olfactory_placode4.36775543
4MP0002234_abnormal_pharynx_morphology3.93380994
5MP0010030_abnormal_orbit_morphology3.74481605
6MP0000778_abnormal_nervous_system3.62247430
7MP0008961_abnormal_basal_metabolism3.48411783
8MP0008789_abnormal_olfactory_epithelium3.17587553
9MP0002282_abnormal_trachea_morphology2.99586718
10MP0000537_abnormal_urethra_morphology2.87340351
11MP0002822_catalepsy2.70012027
12MP0005499_abnormal_olfactory_system2.69141711
13MP0005394_taste/olfaction_phenotype2.69141711
14MP0008438_abnormal_cutaneous_collagen2.65446815
15MP0005423_abnormal_somatic_nervous2.53589182
16MP0005248_abnormal_Harderian_gland2.51097801
17MP0004133_heterotaxia2.40577281
18MP0000631_abnormal_neuroendocrine_gland2.36889180
19MP0003890_abnormal_embryonic-extraembry2.34741189
20MP0009379_abnormal_foot_pigmentation2.30517751
21MP0000049_abnormal_middle_ear2.29184656
22* MP0002751_abnormal_autonomic_nervous2.15336816
23MP0005503_abnormal_tendon_morphology2.15316060
24MP0003938_abnormal_ear_development2.14564368
25MP0003315_abnormal_perineum_morphology2.07228837
26MP0009250_abnormal_appendicular_skeleto2.03095160
27MP0003880_abnormal_central_pattern2.02113202
28MP0003119_abnormal_digestive_system1.94552635
29MP0009053_abnormal_anal_canal1.86419154
30* MP0003861_abnormal_nervous_system1.75870950
31MP0008995_early_reproductive_senescence1.73682327
32MP0001346_abnormal_lacrimal_gland1.69434020
33MP0004859_abnormal_synaptic_plasticity1.68874534
34MP0002938_white_spotting1.68417842
35MP0001986_abnormal_taste_sensitivity1.66600043
36MP0005187_abnormal_penis_morphology1.66199232
37MP0003705_abnormal_hypodermis_morpholog1.65623026
38MP0000026_abnormal_inner_ear1.56775867
39MP0002233_abnormal_nose_morphology1.52876025
40MP0003137_abnormal_impulse_conducting1.47909903
41MP0000428_abnormal_craniofacial_morphol1.41253190
42MP0004145_abnormal_muscle_electrophysio1.40228546
43MP0001286_abnormal_eye_development1.39206715
44MP0003942_abnormal_urinary_system1.38908874
45MP0002116_abnormal_craniofacial_bone1.33626998
46MP0003385_abnormal_body_wall1.32824046
47* MP0000955_abnormal_spinal_cord1.32710049
48MP0002184_abnormal_innervation1.32254946
49MP0002092_abnormal_eye_morphology1.31407570
50MP0003755_abnormal_palate_morphology1.29765910
51MP0006072_abnormal_retinal_apoptosis1.28060232
52MP0003115_abnormal_respiratory_system1.27353104
53MP0005367_renal/urinary_system_phenotyp1.26167869
54MP0000516_abnormal_urinary_system1.26167869
55MP0000569_abnormal_digit_pigmentation1.26025279
56MP0000538_abnormal_urinary_bladder1.25541339
57MP0000733_abnormal_muscle_development1.25350195
58MP0003937_abnormal_limbs/digits/tail_de1.24028494
59* MP0002152_abnormal_brain_morphology1.23527441
60MP0003787_abnormal_imprinting1.16947561
61MP0003121_genomic_imprinting1.16098217
62MP0010386_abnormal_urinary_bladder1.15985715
63MP0002736_abnormal_nociception_after1.15767791
64MP0002932_abnormal_joint_morphology1.14466684
65MP0002734_abnormal_mechanical_nocicepti1.12594794
66MP0008932_abnormal_embryonic_tissue1.09926483
67* MP0002882_abnormal_neuron_morphology1.08837606
68MP0005391_vision/eye_phenotype1.06232213
69MP0001188_hyperpigmentation1.05628439
70* MP0002752_abnormal_somatic_nervous1.04163760
71MP0000467_abnormal_esophagus_morphology1.03201580
72MP0003935_abnormal_craniofacial_develop1.02029161
73MP0002735_abnormal_chemical_nociception1.01631587
74MP0005076_abnormal_cell_differentiation1.01470721
75MP0001485_abnormal_pinna_reflex0.99933484
76* MP0002081_perinatal_lethality0.99901055
77* MP0004811_abnormal_neuron_physiology0.99816381
78MP0002557_abnormal_social/conspecific_i0.99336342
79MP0001529_abnormal_vocalization0.99202873
80MP0001293_anophthalmia0.98243946
81MP0003283_abnormal_digestive_organ0.98086856
82MP0003123_paternal_imprinting0.96831979
83MP0006276_abnormal_autonomic_nervous0.95784775
84MP0001440_abnormal_grooming_behavior0.93371691
85MP0004270_analgesia0.91958812
86MP0002697_abnormal_eye_size0.91142265
87MP0002085_abnormal_embryonic_tissue0.90975710
88MP0001905_abnormal_dopamine_level0.90388254
89MP0003959_abnormal_lean_body0.89131185
90MP0003122_maternal_imprinting0.88524025
91MP0004142_abnormal_muscle_tone0.87626937
92MP0002084_abnormal_developmental_patter0.86794947
93MP0009384_cardiac_valve_regurgitation0.86755281
94MP0004924_abnormal_behavior0.85704147
95MP0005386_behavior/neurological_phenoty0.85704147
96MP0005257_abnormal_intraocular_pressure0.84437066
97MP0002249_abnormal_larynx_morphology0.83953397
98MP0001486_abnormal_startle_reflex0.82494488
99MP0002102_abnormal_ear_morphology0.82484924
100MP0000432_abnormal_head_morphology0.81484564
101MP0004885_abnormal_endolymph0.80317320
102MP0001299_abnormal_eye_distance/0.79098883
103MP0000462_abnormal_digestive_system0.78912467
104MP0002572_abnormal_emotion/affect_behav0.78890572
105MP0002108_abnormal_muscle_morphology0.78635924
106MP0002177_abnormal_outer_ear0.78163828
107MP0002067_abnormal_sensory_capabilities0.77595917
108MP0002109_abnormal_limb_morphology0.77251493
109MP0005197_abnormal_uvea_morphology0.76839836
110MP0005195_abnormal_posterior_eye0.76535363
111MP0000383_abnormal_hair_follicle0.76105068
112MP0002063_abnormal_learning/memory/cond0.75374245
113MP0005645_abnormal_hypothalamus_physiol0.73433651
114MP0000678_abnormal_parathyroid_gland0.71826035
115MP0004742_abnormal_vestibular_system0.71487059
116MP0005253_abnormal_eye_physiology0.70813531
117MP0004134_abnormal_chest_morphology0.69645509
118MP0005646_abnormal_pituitary_gland0.69116818
119MP0003635_abnormal_synaptic_transmissio0.64079991
120MP0002114_abnormal_axial_skeleton0.63748426
121MP0003136_yellow_coat_color0.61981172
122MP0002111_abnormal_tail_morphology0.61817537
123MP0002163_abnormal_gland_morphology0.61653825
124MP0000647_abnormal_sebaceous_gland0.60439588
125MP0004858_abnormal_nervous_system0.60379446
126MP0001340_abnormal_eyelid_morphology0.60106799
127* MP0010770_preweaning_lethality0.59465444
128* MP0002082_postnatal_lethality0.59465444
129MP0001943_abnormal_respiration0.58794235
130MP0002638_abnormal_pupillary_reflex0.58280879
131MP0000762_abnormal_tongue_morphology0.58095056
132MP0000534_abnormal_ureter_morphology0.57967581

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)5.01202792
2Short 4th metacarpal (HP:0010044)4.60170647
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.60170647
4Oligodactyly (HP:0012165)4.55526819
5Down-sloping shoulders (HP:0200021)4.39627455
6High anterior hairline (HP:0009890)4.15979490
7Septo-optic dysplasia (HP:0100842)4.05967454
8Intestinal atresia (HP:0011100)4.04757662
9Chin dimple (HP:0010751)4.00002574
10Hepatoblastoma (HP:0002884)3.84316382
11Coronal craniosynostosis (HP:0004440)3.58477160
12Abnormality of the 4th metacarpal (HP:0010012)3.57377794
13Abnormality of the pulmonary veins (HP:0011718)3.52653145
14Abnormality of the parathyroid morphology (HP:0011766)3.39010712
15Growth hormone deficiency (HP:0000824)3.38366247
16Esophageal atresia (HP:0002032)3.34828090
17Premature rupture of membranes (HP:0001788)3.33127585
18Anophthalmia (HP:0000528)3.29294580
19Sex reversal (HP:0012245)3.23743201
20Abnormal sex determination (HP:0012244)3.23743201
21Aortic aneurysm (HP:0004942)3.22058854
22Aqueductal stenosis (HP:0002410)3.21207452
23Aortic dissection (HP:0002647)3.17448734
24Abnormality of the antihelix (HP:0009738)3.10203985
25Hemivertebrae (HP:0002937)3.07563625
26Bladder diverticulum (HP:0000015)3.00807334
27Concave nail (HP:0001598)3.00767780
28Soft skin (HP:0000977)2.99847529
29Aplasia of the musculature (HP:0100854)2.99041760
30Abnormal number of incisors (HP:0011064)2.91030174
31Congenital malformation of the right heart (HP:0011723)2.90809653
32Double outlet right ventricle (HP:0001719)2.90809653
33Exotropia (HP:0000577)2.86825766
34Facial hemangioma (HP:0000329)2.81828100
35Vitreoretinal degeneration (HP:0000655)2.70735200
36Anterior segment dysgenesis (HP:0007700)2.64731472
37Germ cell neoplasia (HP:0100728)2.64704686
38Midline defect of the nose (HP:0004122)2.57141019
39Maternal diabetes (HP:0009800)2.54703976
40Pendular nystagmus (HP:0012043)2.54284113
41Renal hypoplasia (HP:0000089)2.52814712
42Cerebellar dysplasia (HP:0007033)2.52242126
43Labial hypoplasia (HP:0000066)2.50645856
44Abnormality of the intervertebral disk (HP:0005108)2.50582637
45Bowel diverticulosis (HP:0005222)2.49959420
46Wide anterior fontanel (HP:0000260)2.49743019
47Alacrima (HP:0000522)2.47412280
48Abdominal situs inversus (HP:0003363)2.46859656
49Abnormality of abdominal situs (HP:0011620)2.46859656
50Anosmia (HP:0000458)2.45337816
51Absent septum pellucidum (HP:0001331)2.44739497
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.43380213
53Type II lissencephaly (HP:0007260)2.42945128
54Infantile muscular hypotonia (HP:0008947)2.42703167
55Amblyopia (HP:0000646)2.42362405
56Abnormality of the labia minora (HP:0012880)2.42196718
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.41924443
58Increased corneal curvature (HP:0100692)2.41521583
59Keratoconus (HP:0000563)2.41521583
60Deep palmar crease (HP:0006191)2.40315843
61Bifid scrotum (HP:0000048)2.38509471
62Rib fusion (HP:0000902)2.28286708
63Mixed hearing impairment (HP:0000410)2.28015602
64Broad ribs (HP:0000885)2.27112063
65Vascular tortuosity (HP:0004948)2.21554281
66Hypoplastic female external genitalia (HP:0012815)2.21524009
67Cerebral aneurysm (HP:0004944)2.20416345
68Atrophic scars (HP:0001075)2.19202578
69Peritonitis (HP:0002586)2.17850647
70Abnormality of the septum pellucidum (HP:0007375)2.14682602
71Chorioretinal atrophy (HP:0000533)2.13553666
72Preaxial foot polydactyly (HP:0001841)2.13495638
73Diastasis recti (HP:0001540)2.13151141
74Hydroureter (HP:0000072)2.12514619
75Shallow orbits (HP:0000586)2.12010147
76Gait imbalance (HP:0002141)2.11727688
77Medial flaring of the eyebrow (HP:0010747)2.09598281
78Overfolded helix (HP:0000396)2.07845813
79Gastrointestinal atresia (HP:0002589)2.07833865
80Autism (HP:0000717)2.07049018
81Tented upper lip vermilion (HP:0010804)2.03935603
82Lissencephaly (HP:0001339)2.03328181
83Nephronophthisis (HP:0000090)2.03009609
84Optic nerve hypoplasia (HP:0000609)2.02420118
85Hyperventilation (HP:0002883)2.01282063
86Retinal dysplasia (HP:0007973)2.00142057
87Skull defect (HP:0001362)1.99627769
88Aplasia/Hypoplasia of the nipples (HP:0006709)1.98552362
89Cupped ear (HP:0000378)1.96282822
90Congenital primary aphakia (HP:0007707)1.95629674
91Renal duplication (HP:0000075)1.94529050
92Nephrogenic diabetes insipidus (HP:0009806)1.94498740
93Patellar dislocation (HP:0002999)1.94370671
94Partial duplication of thumb phalanx (HP:0009944)1.93305322
95Abnormality of the right ventricle (HP:0001707)1.93214955
96Arterial tortuosity (HP:0005116)1.93056807
97Excessive salivation (HP:0003781)1.91927661
98Drooling (HP:0002307)1.91927661
99Abnormally folded helix (HP:0008544)1.91754281
100Anal stenosis (HP:0002025)1.91480354
101Spina bifida occulta (HP:0003298)1.90792607
102Abnormality of chromosome segregation (HP:0002916)1.89408980
103Pachygyria (HP:0001302)1.88397824
104Elfin facies (HP:0004428)1.88121577
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86504604
106Renovascular hypertension (HP:0100817)1.85882998
107Aplasia involving forearm bones (HP:0009822)1.85658387
108Absent forearm bone (HP:0003953)1.85658387
109Abnormality of the diencephalon (HP:0010662)1.84864385
110Abnormality of the renal medulla (HP:0100957)1.84275448
111Decreased lacrimation (HP:0000633)1.83913649
112Protrusio acetabuli (HP:0003179)1.83891139
113Abnormality of the metopic suture (HP:0005556)1.83189964
114Holoprosencephaly (HP:0001360)1.81753968
115Buphthalmos (HP:0000557)1.81025708
116Abnormality of the aortic arch (HP:0012303)1.81020543
117Cutaneous finger syndactyly (HP:0010554)1.80884200
118Wide cranial sutures (HP:0010537)1.80679116
119Obsessive-compulsive behavior (HP:0000722)1.80176511
120Partial duplication of the phalanx of hand (HP:0009999)1.79160097
121Hyperacusis (HP:0010780)1.78895155
122Metaphyseal dysplasia (HP:0100255)1.77854783
123Breast hypoplasia (HP:0003187)1.77338940
124Pseudobulbar signs (HP:0002200)1.76815463
125Neonatal short-limb short stature (HP:0008921)1.75224299
126Absent radius (HP:0003974)1.73899032
127Hypoplasia of the brainstem (HP:0002365)1.73859312
128Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73859312
129Focal motor seizures (HP:0011153)1.73729404
130Hypoplastic left heart (HP:0004383)1.73505636
131Broad metatarsal (HP:0001783)1.72938635
132Broad phalanx (HP:0006009)1.72794268
133Adrenal hypoplasia (HP:0000835)1.72692939
134Broad long bones (HP:0005622)1.72639862
135Trigonocephaly (HP:0000243)1.72003987
136Laryngomalacia (HP:0001601)1.71971090
137Abnormality of the incisor (HP:0000676)1.70483456
138Hallux valgus (HP:0001822)1.70346234
139Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70292394
140Tubulointerstitial fibrosis (HP:0005576)1.69890746
141Abnormality of the shoulder girdle musculature (HP:0001435)1.69556548
142Shoulder girdle muscle weakness (HP:0003547)1.69445748
143Abnormality of the renal cortex (HP:0011035)1.69016868
144Absent speech (HP:0001344)1.68970491
145Renal cortical cysts (HP:0000803)1.68753558
146Broad-based gait (HP:0002136)1.68739832
147Anteriorly placed anus (HP:0001545)1.68673825
148Abnormality of the labia (HP:0000058)1.68242900
149Hypoplastic nipples (HP:0002557)1.67970990
150Flat cornea (HP:0007720)1.67878041
151Cortical dysplasia (HP:0002539)1.67562197
152Lymphangioma (HP:0100764)1.67529384
153Asymmetry of the thorax (HP:0001555)1.67444369
154Shawl scrotum (HP:0000049)1.67326056
155Fibular hypoplasia (HP:0003038)1.66903639
156Ridged nail (HP:0001807)1.66874329
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.66849419
158Hypoplastic heart (HP:0001961)1.66641435
159Anomalous pulmonary venous return (HP:0010772)1.66178845
160Abnormality of dentin (HP:0010299)1.65673697
161Hypospadias (HP:0000047)1.64860387
162Anencephaly (HP:0002323)1.64807901
163Broad hallux (HP:0010055)1.64299212
164Small hand (HP:0200055)1.64142259
165Prominent occiput (HP:0000269)1.63982517
166Hip dysplasia (HP:0001385)1.63805142
167Complete atrioventricular canal defect (HP:0001674)1.63642119
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62146421
169Increased number of teeth (HP:0011069)1.61720753
170Cutaneous syndactyly (HP:0012725)1.61547678
171Deviation of the hallux (HP:0010051)1.60920724
172Macrocytic anemia (HP:0001972)1.60856294
173Micropenis (HP:0000054)1.59895886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB27.17018847
2EPHA34.07515150
3KSR13.67010376
4MKNK12.73745384
5MARK12.57804266
6UHMK12.51472296
7LATS22.37892332
8PBK2.34558701
9BRSK12.24802475
10MKNK22.22503508
11EPHA42.20312570
12ERBB22.15383608
13ICK2.14529098
14SRPK12.11467410
15AKT32.03069828
16MELK2.01600816
17MAP3K102.00363632
18ERBB31.97578824
19CDK191.92783488
20NTRK11.87393449
21BRSK21.68882752
22DYRK1B1.68837152
23BRD41.65408286
24TAF11.61624186
25DYRK31.59805060
26TRIB31.58872852
27DYRK21.57984922
28MAP3K41.54045582
29NUAK11.51554271
30IRAK21.46736045
31BCR1.42163028
32STK391.40271477
33MAPK151.39968750
34ADRBK21.39804951
35PKN21.37317091
36MAP2K71.30698461
37CDC42BPA1.25574672
38TGFBR11.25469451
39PASK1.25244684
40FGFR21.24045006
41CDC71.22672979
42INSRR1.21626763
43WNK31.20824287
44NTRK21.20562125
45EEF2K1.19139364
46PAK61.17532185
47CLK11.17391378
48PIM21.15778978
49VRK11.14739370
50SGK4941.14466689
51SGK2231.14466689
52PAK31.14085830
53CAMKK11.11323029
54TYRO31.03709583
55CSNK1G31.01456189
56ILK1.01001234
57IRAK11.00048662
58ROCK20.98598634
59SGK20.97873458
60CDK90.97732052
61MYLK0.92427429
62PRKCG0.91299103
63CDK70.87242540
64CDK120.86396190
65ACVR1B0.84777382
66CSNK1A1L0.82273196
67PLK30.82040861
68OXSR10.81306132
69MAPK130.79371191
70CSNK1G10.78564584
71DAPK30.78563386
72SIK20.78473212
73VRK20.76694873
74TAOK30.73718403
75MAPK110.73298844
76BMPR1B0.73219768
77CAMKK20.72061599
78PNCK0.71763706
79CDK180.68237697
80BUB10.68195666
81MINK10.66874225
82CDK80.66665161
83AURKA0.66659435
84PAK40.66629370
85CDK140.65034615
86PTK60.63661950
87CSNK1G20.63473304
88YES10.62879657
89CDK150.62783568
90RPS6KA10.62082058
91PIK3CG0.61156655
92NME10.60392181
93DYRK1A0.60114249
94LRRK20.56665678
95CDK30.56345441
96FGR0.56294079
97PKN10.56105369
98CDK11A0.55405060
99CAMK10.53909050
100TLK10.53270815
101PRKCZ0.53035152
102LATS10.52389416
103CSNK1E0.52026649
104ZAK0.50789423
105SIK30.50130193
106CDK10.49751834
107RPS6KA60.49539608
108RPS6KL10.48813693
109RPS6KC10.48813693
110CHEK10.48519174
111MOS0.48187039
112MAP2K20.48040255
113WEE10.47810580
114MAPKAPK50.47141517
115CCNB10.47118138
116PDGFRA0.46604325
117PRKCH0.45557750
118PRKG10.45543589
119NTRK30.45468913
120CAMK1D0.45450405
121ROCK10.44713332
122FGFR10.44323194
123ADRBK10.44307678
124PLK10.42972211
125MAPK90.42679018
126CAMK1G0.41846077
127CDK60.41434046
128PLK20.40429708
129MAP3K80.40345656
130PAK20.40169302
131TNIK0.39773384
132RPS6KA20.39615611
133MAPK40.39424194
134CDK20.37251269
135ATR0.37000008
136MAP2K40.36593210
137NEK90.36550069
138SIK10.35791430
139STK110.34321523
140TAOK20.33336813
141AURKB0.31486024
142KSR20.31446829
143CHEK20.30331743
144CDK50.29884370
145MARK30.29096066
146CASK0.28466764
147DDR20.28252103

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043305.65570455
2Axon guidance_Homo sapiens_hsa043604.24550439
3Basal cell carcinoma_Homo sapiens_hsa052174.18866340
4Spliceosome_Homo sapiens_hsa030403.47306167
5Hedgehog signaling pathway_Homo sapiens_hsa043402.72625544
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.67739414
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.66608918
8Hippo signaling pathway_Homo sapiens_hsa043902.47959562
9Protein digestion and absorption_Homo sapiens_hsa049742.23160251
10Oxidative phosphorylation_Homo sapiens_hsa001902.20047923
11Parkinsons disease_Homo sapiens_hsa050122.19826168
12mRNA surveillance pathway_Homo sapiens_hsa030152.19308362
13Cell cycle_Homo sapiens_hsa041102.16688018
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16031397
15MicroRNAs in cancer_Homo sapiens_hsa052062.14036328
16Wnt signaling pathway_Homo sapiens_hsa043102.03343205
17Systemic lupus erythematosus_Homo sapiens_hsa053222.01419955
18Melanogenesis_Homo sapiens_hsa049161.73301983
19Colorectal cancer_Homo sapiens_hsa052101.69721963
20Lysine degradation_Homo sapiens_hsa003101.68905944
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.53551373
22Alzheimers disease_Homo sapiens_hsa050101.53092445
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51593855
24Alcoholism_Homo sapiens_hsa050341.51085615
25Ribosome_Homo sapiens_hsa030101.50352370
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44714187
27TGF-beta signaling pathway_Homo sapiens_hsa043501.31461947
28Endometrial cancer_Homo sapiens_hsa052131.29021462
29Dorso-ventral axis formation_Homo sapiens_hsa043201.23585841
30RNA transport_Homo sapiens_hsa030131.22008104
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21975979
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16909272
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14358805
34Renal cell carcinoma_Homo sapiens_hsa052111.12010049
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11913627
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10632433
37Protein export_Homo sapiens_hsa030601.10455535
38Viral myocarditis_Homo sapiens_hsa054161.10257934
39Chronic myeloid leukemia_Homo sapiens_hsa052201.08485674
40Gap junction_Homo sapiens_hsa045401.03711525
41Oocyte meiosis_Homo sapiens_hsa041141.01032823
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98029155
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97324499
44Circadian entrainment_Homo sapiens_hsa047130.97175403
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94940240
46Glioma_Homo sapiens_hsa052140.94729147
47Glutamatergic synapse_Homo sapiens_hsa047240.93932209
48Prion diseases_Homo sapiens_hsa050200.92360589
49Pathways in cancer_Homo sapiens_hsa052000.92103972
50Proteoglycans in cancer_Homo sapiens_hsa052050.90433339
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90190697
52HTLV-I infection_Homo sapiens_hsa051660.90092308
53Dopaminergic synapse_Homo sapiens_hsa047280.89837891
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89676691
55Bladder cancer_Homo sapiens_hsa052190.88707066
56cAMP signaling pathway_Homo sapiens_hsa040240.87965502
57Basal transcription factors_Homo sapiens_hsa030220.87701348
58Tight junction_Homo sapiens_hsa045300.85870688
59GABAergic synapse_Homo sapiens_hsa047270.85513997
60Nicotine addiction_Homo sapiens_hsa050330.78853874
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77756068
62Non-small cell lung cancer_Homo sapiens_hsa052230.77033978
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76086724
64Cardiac muscle contraction_Homo sapiens_hsa042600.75044173
65Pancreatic cancer_Homo sapiens_hsa052120.73578984
66Homologous recombination_Homo sapiens_hsa034400.73450663
67Melanoma_Homo sapiens_hsa052180.70229494
68ECM-receptor interaction_Homo sapiens_hsa045120.69620275
69ErbB signaling pathway_Homo sapiens_hsa040120.69603903
70p53 signaling pathway_Homo sapiens_hsa041150.68409802
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68161937
72Long-term depression_Homo sapiens_hsa047300.67051164
73Cholinergic synapse_Homo sapiens_hsa047250.66676077
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64909996
75Cocaine addiction_Homo sapiens_hsa050300.64767044
76Small cell lung cancer_Homo sapiens_hsa052220.64759874
77Phototransduction_Homo sapiens_hsa047440.63763481
78Adherens junction_Homo sapiens_hsa045200.63567885
79FoxO signaling pathway_Homo sapiens_hsa040680.62717314
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61390368
81Olfactory transduction_Homo sapiens_hsa047400.60663596
82RNA polymerase_Homo sapiens_hsa030200.60538441
83Focal adhesion_Homo sapiens_hsa045100.59451073
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59266825
85Autoimmune thyroid disease_Homo sapiens_hsa053200.58576964
86Serotonergic synapse_Homo sapiens_hsa047260.58111115
87Epstein-Barr virus infection_Homo sapiens_hsa051690.57049442
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52890840
89Gastric acid secretion_Homo sapiens_hsa049710.52512859
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52064302
91Viral carcinogenesis_Homo sapiens_hsa052030.51257536
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.50641065
93Taste transduction_Homo sapiens_hsa047420.47806260
94Butanoate metabolism_Homo sapiens_hsa006500.47426029
95Rap1 signaling pathway_Homo sapiens_hsa040150.47096960
96VEGF signaling pathway_Homo sapiens_hsa043700.47042297
97Selenocompound metabolism_Homo sapiens_hsa004500.45627124
98Long-term potentiation_Homo sapiens_hsa047200.45498096
99Hepatitis B_Homo sapiens_hsa051610.43667445
100Ras signaling pathway_Homo sapiens_hsa040140.41448849
101Non-homologous end-joining_Homo sapiens_hsa034500.40926473
102Choline metabolism in cancer_Homo sapiens_hsa052310.40580568
103Morphine addiction_Homo sapiens_hsa050320.40443497
104Regulation of autophagy_Homo sapiens_hsa041400.39728114
105Prolactin signaling pathway_Homo sapiens_hsa049170.39702193
106Insulin secretion_Homo sapiens_hsa049110.39227292
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38226786
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.36421037
109Oxytocin signaling pathway_Homo sapiens_hsa049210.35993627
110MAPK signaling pathway_Homo sapiens_hsa040100.35254011
111RNA degradation_Homo sapiens_hsa030180.34838741
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34403763
113Prostate cancer_Homo sapiens_hsa052150.34204982
114Steroid biosynthesis_Homo sapiens_hsa001000.33330226
115Renin secretion_Homo sapiens_hsa049240.32467375
116Synaptic vesicle cycle_Homo sapiens_hsa047210.32306497
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31597522
118Amphetamine addiction_Homo sapiens_hsa050310.31543331
119Estrogen signaling pathway_Homo sapiens_hsa049150.31118787
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.30905305
121Nucleotide excision repair_Homo sapiens_hsa034200.29657662
122mTOR signaling pathway_Homo sapiens_hsa041500.27571934
123AMPK signaling pathway_Homo sapiens_hsa041520.27226150
124Dilated cardiomyopathy_Homo sapiens_hsa054140.26219880
125Huntingtons disease_Homo sapiens_hsa050160.25640189
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.19242941
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18690950
128Type II diabetes mellitus_Homo sapiens_hsa049300.18148444
129T cell receptor signaling pathway_Homo sapiens_hsa046600.16875776

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