NEUROG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peristalsis (GO:0030432)8.99595390
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)8.36535598
3substrate-independent telencephalic tangential migration (GO:0021826)8.36535598
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)8.35529917
5positive regulation of growth hormone secretion (GO:0060124)7.56270252
6behavioral response to nicotine (GO:0035095)7.35921677
7negative regulation of cytosolic calcium ion concentration (GO:0051481)7.06290924
8auditory behavior (GO:0031223)7.03363718
9regulation of growth hormone secretion (GO:0060123)6.68601422
10response to inactivity (GO:0014854)6.67610147
11pyrimidine nucleobase catabolic process (GO:0006208)6.49573484
12neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)6.35665518
13regulation of synapse structural plasticity (GO:0051823)6.35657176
14detection of temperature stimulus (GO:0016048)5.99261032
15planar cell polarity pathway involved in neural tube closure (GO:0090179)5.81723117
16negative regulation of catecholamine secretion (GO:0033604)5.79523519
17phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.61567748
18response to histamine (GO:0034776)5.53547887
19lateral sprouting from an epithelium (GO:0060601)5.44831150
20regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.37829861
21regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.37829861
22mechanosensory behavior (GO:0007638)5.35202485
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.15607865
24behavioral response to ethanol (GO:0048149)5.10697601
25negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.10578849
26cranial nerve development (GO:0021545)5.01175483
27nucleobase catabolic process (GO:0046113)4.98949292
28striatum development (GO:0021756)4.81573869
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.78294003
30G-protein coupled receptor internalization (GO:0002031)4.71616392
31establishment of tissue polarity (GO:0007164)4.71196714
32establishment of planar polarity (GO:0001736)4.71196714
33phasic smooth muscle contraction (GO:0014821)4.68225399
34spinal cord association neuron differentiation (GO:0021527)4.62433900
35nerve growth factor signaling pathway (GO:0038180)4.56530497
36synaptic transmission, dopaminergic (GO:0001963)4.54599021
37prepulse inhibition (GO:0060134)4.54491217
38response to auditory stimulus (GO:0010996)4.44065700
39notochord development (GO:0030903)4.40728704
40neuronal stem cell maintenance (GO:0097150)4.36860163
41regulation of dopamine secretion (GO:0014059)4.34539823
42epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.32898519
43behavioral response to cocaine (GO:0048148)4.31110735
44neuromuscular synaptic transmission (GO:0007274)4.30379366
45neuron fate specification (GO:0048665)4.28050874
46cellular response to nicotine (GO:0071316)4.27954906
47negative regulation of adenylate cyclase activity (GO:0007194)4.27317670
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25307415
49regulation of chromatin binding (GO:0035561)4.18625621
50G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.17601470
51detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.13789285
52detection of temperature stimulus involved in sensory perception (GO:0050961)4.13789285
53glial cell proliferation (GO:0014009)4.12338664
54regulation of circadian sleep/wake cycle, sleep (GO:0045187)4.07732037
55regulation of circadian sleep/wake cycle (GO:0042749)4.07732037
56negative regulation of cyclase activity (GO:0031280)4.06240052
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06178933
58DNA unwinding involved in DNA replication (GO:0006268)3.94145181
59protein-DNA complex disassembly (GO:0032986)3.90830718
60nucleosome disassembly (GO:0006337)3.90830718
61centriole replication (GO:0007099)3.89324313
62negative regulation of lyase activity (GO:0051350)3.89073952
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81998326
64cranial nerve morphogenesis (GO:0021602)3.80457967
65cochlea morphogenesis (GO:0090103)3.78467799
66positive regulation of neurotransmitter transport (GO:0051590)3.75747462
67cell migration in hindbrain (GO:0021535)3.73484184
68regulation of neurotransmitter uptake (GO:0051580)3.73468908
69nerve development (GO:0021675)3.72425141
70positive regulation of gastrulation (GO:2000543)3.72059243
71response to nicotine (GO:0035094)3.72051470
72Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.67927257
73pre-miRNA processing (GO:0031054)3.65113788
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.63163421
75neuron fate determination (GO:0048664)3.62841474
76microtubule depolymerization (GO:0007019)3.58212513
77negative regulation of RNA splicing (GO:0033119)3.57079060
78negative regulation of amine transport (GO:0051953)3.56989152
79negative regulation of circadian rhythm (GO:0042754)3.56256632
80negative regulation of transcription regulatory region DNA binding (GO:2000678)3.51665492
81negative regulation of axon extension involved in axon guidance (GO:0048843)3.51390212
82peptidyl-arginine methylation (GO:0018216)3.50983823
83peptidyl-arginine N-methylation (GO:0035246)3.50983823
84neurofilament cytoskeleton organization (GO:0060052)3.49703312
85positive regulation of urine volume (GO:0035810)3.48413720
86mesoderm development (GO:0007498)3.46961109
87regulation of transcription regulatory region DNA binding (GO:2000677)3.44261463
88neuron recognition (GO:0008038)3.40265222
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.39928846
90convergent extension (GO:0060026)3.39585713
91face development (GO:0060324)3.39320119
92heart valve formation (GO:0003188)3.38154475
93pattern specification involved in kidney development (GO:0061004)3.37123575
94regulation of establishment of planar polarity (GO:0090175)3.36978663
95negative regulation of cAMP biosynthetic process (GO:0030818)3.35502948
96neuron migration (GO:0001764)3.35185109
97synaptic transmission, cholinergic (GO:0007271)3.34696652
98regulation of voltage-gated calcium channel activity (GO:1901385)3.33563359
99endocardial cushion morphogenesis (GO:0003203)3.33476259
100arachidonic acid secretion (GO:0050482)3.32690639
101icosanoid secretion (GO:0032309)3.32690639
102negative regulation of mRNA processing (GO:0050686)3.31202362
103mesenchyme morphogenesis (GO:0072132)3.28363494
104non-canonical Wnt signaling pathway (GO:0035567)3.27629938
105glutamate secretion (GO:0014047)3.26310778
106sympathetic nervous system development (GO:0048485)3.24725243
107adult walking behavior (GO:0007628)3.24328705
108negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.22563945
109synaptic vesicle maturation (GO:0016188)3.20238335
110peptidyl-arginine omega-N-methylation (GO:0035247)3.19819347
111circadian sleep/wake cycle process (GO:0022410)3.19305340
112regulation of mRNA splicing, via spliceosome (GO:0048024)3.18971235
113negative regulation of cAMP metabolic process (GO:0030815)3.17841608
114synapse assembly (GO:0007416)3.17616838
115neuronal ion channel clustering (GO:0045161)3.14879131
116axon ensheathment in central nervous system (GO:0032291)3.13878112
117central nervous system myelination (GO:0022010)3.13878112
118regulation of synaptic transmission, dopaminergic (GO:0032225)3.13249328
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12974259
120kinetochore assembly (GO:0051382)3.12227860
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.10598234
122mRNA splicing, via spliceosome (GO:0000398)3.10598234
123viral mRNA export from host cell nucleus (GO:0046784)3.09954378
124regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.09847942
125negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.06516272
126regulation of catecholamine secretion (GO:0050433)3.05798673
127transmission of nerve impulse (GO:0019226)3.05594179
128establishment or maintenance of monopolar cell polarity (GO:0061339)3.04740579
129establishment of monopolar cell polarity (GO:0061162)3.04740579
130positive regulation of renal sodium excretion (GO:0035815)3.02808472
131positive regulation of transcription regulatory region DNA binding (GO:2000679)3.02771306
132negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.02234352
133negative regulation of nucleotide biosynthetic process (GO:0030809)3.02234352
134RNA splicing, via transesterification reactions (GO:0000375)3.00707333
135positive regulation of RNA splicing (GO:0033120)2.96948431
136forebrain neuron differentiation (GO:0021879)2.96072061
137limb bud formation (GO:0060174)2.94245546
138facial nerve structural organization (GO:0021612)2.92532945
139telencephalon cell migration (GO:0022029)2.91614243
140negative regulation of axon guidance (GO:1902668)2.91159427
141ephrin receptor signaling pathway (GO:0048013)2.91075670
142spliceosomal complex assembly (GO:0000245)2.89777041
143response to nerve growth factor (GO:1990089)2.89741316
144cellular response to nerve growth factor stimulus (GO:1990090)2.89741316
145spinal cord development (GO:0021510)2.89275312
146mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.88807631
147positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.88807631
148midbrain development (GO:0030901)2.87365664
149ganglion development (GO:0061548)2.85709331
150kinetochore organization (GO:0051383)2.84802217
151centriole assembly (GO:0098534)2.84768619
152mesenchyme development (GO:0060485)2.84426137
153proximal/distal pattern formation (GO:0009954)2.84275501
154negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.83683972
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.82868576
156glucocorticoid biosynthetic process (GO:0006704)2.82543212
157segment specification (GO:0007379)2.82504337
158regulation of helicase activity (GO:0051095)2.81992036
159ATP-dependent chromatin remodeling (GO:0043044)2.79477849
160forebrain cell migration (GO:0021885)2.79191279
161embryonic hindlimb morphogenesis (GO:0035116)2.78738940
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.78624936
163spliceosomal tri-snRNP complex assembly (GO:0000244)2.77196613
164negative regulation of oligodendrocyte differentiation (GO:0048715)2.76639026
165regulation of centriole replication (GO:0046599)2.75752648
166eyelid development in camera-type eye (GO:0061029)2.74785695
167tongue development (GO:0043586)2.73875132
168cell surface receptor signaling pathway involved in heart development (GO:0061311)2.73451187
169short-term memory (GO:0007614)2.73290770
170pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72228029
171regulation of somitogenesis (GO:0014807)2.68284656
172primitive streak formation (GO:0090009)2.68201441
173intra-S DNA damage checkpoint (GO:0031573)2.66926821
174DNA ligation (GO:0006266)2.66759431
175axon extension involved in axon guidance (GO:0048846)2.66120211
176neuron projection extension involved in neuron projection guidance (GO:1902284)2.66120211
177olfactory bulb development (GO:0021772)2.64817140
178axonal fasciculation (GO:0007413)2.64718505
179positive regulation of cell cycle G2/M phase transition (GO:1902751)2.63938473
180positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.63938473
181sex differentiation (GO:0007548)2.62317312
182cerebral cortex radially oriented cell migration (GO:0021799)2.61956247
183hippo signaling (GO:0035329)2.61190983
184middle ear morphogenesis (GO:0042474)2.60388709
185negative regulation of astrocyte differentiation (GO:0048712)2.60147883
186bone trabecula formation (GO:0060346)2.59060914
187mesenchymal cell proliferation (GO:0010463)2.58866713
188regulation of centrosome cycle (GO:0046605)2.57089962
189regulation of oligodendrocyte differentiation (GO:0048713)2.56575440
190histone arginine methylation (GO:0034969)2.56336285
191positive regulation of neuroblast proliferation (GO:0002052)2.55789430
192paraxial mesoderm development (GO:0048339)12.3943094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54124776
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.86195589
3EZH2_22144423_ChIP-Seq_EOC_Human4.72682830
4* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.75697603
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64554958
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.62610664
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.15851231
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.86934078
9REST_21632747_ChIP-Seq_MESCs_Mouse2.70135026
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.60419159
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53563497
12* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.48553366
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.41927065
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.36673233
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36086742
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.32892465
17* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.23821740
18* CBX2_27304074_Chip-Seq_ESCs_Mouse2.22387264
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17097307
20* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.16841805
21* RING1B_27294783_Chip-Seq_NPCs_Mouse2.06783872
22DROSHA_22980978_ChIP-Seq_HELA_Human2.05033332
23* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.03820741
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99060074
25* EED_16625203_ChIP-ChIP_MESCs_Mouse1.96080437
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.94801041
27* ERG_21242973_ChIP-ChIP_JURKAT_Human1.94669526
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92759678
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89205862
30* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89205862
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88869133
32* TP53_20018659_ChIP-ChIP_R1E_Mouse1.87795871
33XRN2_22483619_ChIP-Seq_HELA_Human1.86996890
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.85412801
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83768576
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.79909199
37* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.79775801
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79720429
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.79093114
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78564513
41* SOX2_16153702_ChIP-ChIP_HESCs_Human1.74479457
42* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73887884
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70999105
44* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70623688
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.68364745
46* RNF2_27304074_Chip-Seq_ESCs_Mouse1.63661107
47* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62959145
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62232915
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.60768553
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.60281972
51* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56818935
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55043945
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.53681026
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52525147
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49235483
56* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44655157
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44453135
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42255096
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41869627
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41009861
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37666876
62* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34493142
63CIITA_25753668_ChIP-Seq_RAJI_Human1.32567484
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.32407778
65* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31292206
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27391743
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25538034
68* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25510377
69MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23737262
70KDM2B_26808549_Chip-Seq_K562_Human1.23412490
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20498688
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20265149
73MYC_18940864_ChIP-ChIP_HL60_Human1.19639819
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19480792
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19342098
76KAP1_27257070_Chip-Seq_ESCs_Mouse1.19193237
77* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17465182
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17012952
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16123700
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15989115
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15810995
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14196443
83MYC_22102868_ChIP-Seq_BL_Human1.13153104
84SOX3_22085726_ChIP-Seq_NPCs_Mouse1.11483649
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10898911
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10849941
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09687353
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09662938
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09544704
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09433800
91OCT4_19829295_ChIP-Seq_ESCs_Human1.07426644
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.07401341
93* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07207202
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06645074
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06107335
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05829970
97* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05758825
98* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04342767
99* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04065490
100* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03927075
101CTCF_27219007_Chip-Seq_Bcells_Human1.03168283
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01892687
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.01714700
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01017527
105* TTF2_22483619_ChIP-Seq_HELA_Human0.99949287
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99912686
107MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99320218
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99149499
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98850948
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98660377
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.98509691
112* RNF2_27304074_Chip-Seq_NSC_Mouse0.97947075
113* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97111396
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97090107
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95931897
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95606092
117LXR_22292898_ChIP-Seq_THP-1_Human0.95290807
118ETS1_20019798_ChIP-Seq_JURKAT_Human0.95182657
119* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94291614
120* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93421164
121* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93408812
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93128654
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92935026
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91404943
125KDM2B_26808549_Chip-Seq_DND41_Human0.90708225
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.89542919
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88182740
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87054312
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82784859
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81468202
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80854103
132* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80449260
133KLF4_19829295_ChIP-Seq_ESCs_Human0.79135632
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78910033
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78220930
136* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77928092
137P68_20966046_ChIP-Seq_HELA_Human0.77684447
138MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.76534354
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75779165
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75779165
141* TET1_21490601_ChIP-Seq_MESCs_Mouse0.74691182
142SMC4_20622854_ChIP-Seq_HELA_Human0.73813555
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.73756597
144* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72319173
145POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.71001481
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70910350
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.70567888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.90306879
2MP0002653_abnormal_ependyma_morphology8.07720759
3MP0010030_abnormal_orbit_morphology4.54792935
4MP0008789_abnormal_olfactory_epithelium3.96690231
5MP0005409_darkened_coat_color3.82336512
6MP0005394_taste/olfaction_phenotype3.56392135
7MP0005499_abnormal_olfactory_system3.56392135
8MP0006292_abnormal_olfactory_placode3.53975187
9MP0001529_abnormal_vocalization3.42161583
10MP0000566_synostosis3.24612527
11MP0002909_abnormal_adrenal_gland3.18203516
12MP0004270_analgesia2.96748064
13MP0000778_abnormal_nervous_system2.70684874
14MP0009053_abnormal_anal_canal2.52032553
15MP0000537_abnormal_urethra_morphology2.48083005
16MP0001905_abnormal_dopamine_level2.38779962
17MP0003787_abnormal_imprinting2.37689103
18MP0000049_abnormal_middle_ear2.33076259
19MP0002751_abnormal_autonomic_nervous2.14643708
20MP0004885_abnormal_endolymph2.14224573
21MP0005248_abnormal_Harderian_gland2.13400525
22MP0005257_abnormal_intraocular_pressure2.13325778
23MP0000372_irregular_coat_pigmentation2.12314529
24MP0004858_abnormal_nervous_system2.09025791
25MP0005646_abnormal_pituitary_gland2.01277819
26MP0000428_abnormal_craniofacial_morphol1.99050386
27MP0003385_abnormal_body_wall1.94818224
28MP0001346_abnormal_lacrimal_gland1.82256696
29MP0002734_abnormal_mechanical_nocicepti1.80913792
30MP0002233_abnormal_nose_morphology1.77295441
31MP0002249_abnormal_larynx_morphology1.68986365
32MP0002282_abnormal_trachea_morphology1.67903395
33* MP0003861_abnormal_nervous_system1.67861416
34MP0002638_abnormal_pupillary_reflex1.66575187
35MP0003315_abnormal_perineum_morphology1.63296807
36MP0003938_abnormal_ear_development1.61458016
37MP0000631_abnormal_neuroendocrine_gland1.59578273
38MP0005187_abnormal_penis_morphology1.59179286
39MP0000733_abnormal_muscle_development1.58741031
40MP0003755_abnormal_palate_morphology1.57734732
41MP0001293_anophthalmia1.57695520
42MP0003119_abnormal_digestive_system1.56131984
43MP0002116_abnormal_craniofacial_bone1.53676700
44MP0004811_abnormal_neuron_physiology1.52967895
45MP0005423_abnormal_somatic_nervous1.52643990
46MP0002234_abnormal_pharynx_morphology1.49945791
47MP0001849_ear_inflammation1.47800562
48MP0003937_abnormal_limbs/digits/tail_de1.47018852
49MP0003635_abnormal_synaptic_transmissio1.45172893
50MP0003183_abnormal_peptide_metabolism1.44668776
51MP0002932_abnormal_joint_morphology1.43480055
52MP0003123_paternal_imprinting1.34741363
53MP0004142_abnormal_muscle_tone1.34326816
54MP0002938_white_spotting1.33793343
55MP0002177_abnormal_outer_ear1.32541610
56MP0009250_abnormal_appendicular_skeleto1.31775860
57MP0002111_abnormal_tail_morphology1.28843417
58MP0003890_abnormal_embryonic-extraembry1.27399397
59MP0003115_abnormal_respiratory_system1.25826068
60MP0001348_abnormal_lacrimal_gland1.23796344
61MP0003111_abnormal_nucleus_morphology1.22693699
62MP0002085_abnormal_embryonic_tissue1.22302430
63MP0004133_heterotaxia1.20997200
64MP0002063_abnormal_learning/memory/cond1.20769152
65MP0001486_abnormal_startle_reflex1.20570618
66MP0005670_abnormal_white_adipose1.20317518
67MP0003942_abnormal_urinary_system1.19241897
68MP0010386_abnormal_urinary_bladder1.16258005
69MP0005386_behavior/neurological_phenoty1.15442253
70MP0004924_abnormal_behavior1.15442253
71MP0006072_abnormal_retinal_apoptosis1.14081820
72MP0003880_abnormal_central_pattern1.12357925
73MP0003121_genomic_imprinting1.11347917
74MP0001286_abnormal_eye_development1.09076167
75MP0002092_abnormal_eye_morphology1.09029231
76MP0002272_abnormal_nervous_system1.08408924
77* MP0002752_abnormal_somatic_nervous1.07952983
78* MP0002152_abnormal_brain_morphology1.07620339
79MP0008932_abnormal_embryonic_tissue1.06253905
80MP0002733_abnormal_thermal_nociception1.04948597
81MP0000026_abnormal_inner_ear1.04699735
82MP0003122_maternal_imprinting1.04412716
83* MP0002081_perinatal_lethality1.03449791
84MP0009745_abnormal_behavioral_response1.02117230
85MP0003935_abnormal_craniofacial_develop1.01282378
86MP0002084_abnormal_developmental_patter0.97760436
87MP0002160_abnormal_reproductive_system0.96960546
88MP0004957_abnormal_blastocyst_morpholog0.96826419
89MP0001440_abnormal_grooming_behavior0.96121079
90MP0001984_abnormal_olfaction0.96109947
91MP0005391_vision/eye_phenotype0.95903464
92MP0002114_abnormal_axial_skeleton0.95749781
93MP0002572_abnormal_emotion/affect_behav0.95708857
94MP0000762_abnormal_tongue_morphology0.94354609
95MP0002067_abnormal_sensory_capabilities0.93792546
96MP0002184_abnormal_innervation0.93691498
97MP0000613_abnormal_salivary_gland0.92944654
98MP0000534_abnormal_ureter_morphology0.89630647
99MP0005645_abnormal_hypothalamus_physiol0.88295029
100MP0005195_abnormal_posterior_eye0.88177033
101MP0002557_abnormal_social/conspecific_i0.87707750
102MP0001299_abnormal_eye_distance/0.87563771
103* MP0002882_abnormal_neuron_morphology0.86954367
104MP0001970_abnormal_pain_threshold0.86782251
105MP0003136_yellow_coat_color0.86473982
106MP0005076_abnormal_cell_differentiation0.85689600
107MP0002735_abnormal_chemical_nociception0.85596219
108MP0001730_embryonic_growth_arrest0.83810735
109MP0001485_abnormal_pinna_reflex0.83555534
110MP0003137_abnormal_impulse_conducting0.82267008
111MP0002736_abnormal_nociception_after0.81794131
112MP0003693_abnormal_embryo_hatching0.81563534
113MP0000751_myopathy0.81523778
114MP0006276_abnormal_autonomic_nervous0.81521547
115MP0003948_abnormal_gas_homeostasis0.80862675
116MP0002697_abnormal_eye_size0.80777484
117MP0000432_abnormal_head_morphology0.79963851
118MP0004085_abnormal_heartbeat0.78472040
119MP0005174_abnormal_tail_pigmentation0.78314711
120* MP0002069_abnormal_eating/drinking_beha0.78160211
121MP0003077_abnormal_cell_cycle0.78152933
122MP0005197_abnormal_uvea_morphology0.77649963
123MP0005508_abnormal_skeleton_morphology0.77482045
124MP0001672_abnormal_embryogenesis/_devel0.74780502
125MP0005380_embryogenesis_phenotype0.74780502
126MP0002163_abnormal_gland_morphology0.74274154
127MP0000350_abnormal_cell_proliferation0.73333722
128MP0001697_abnormal_embryo_size0.72915695
129MP0000490_abnormal_crypts_of0.72184446
130MP0010094_abnormal_chromosome_stability0.71354276
131MP0001340_abnormal_eyelid_morphology0.71048644
132MP0001919_abnormal_reproductive_system0.70789660
133MP0000538_abnormal_urinary_bladder0.70617914
134MP0004859_abnormal_synaptic_plasticity0.70595855
135MP0005379_endocrine/exocrine_gland_phen0.69771891
136MP0008007_abnormal_cellular_replicative0.69691859
137MP0000639_abnormal_adrenal_gland0.69473029
138MP0000955_abnormal_spinal_cord0.68581063
139MP0005623_abnormal_meninges_morphology0.68169494
140MP0002066_abnormal_motor_capabilities/c0.67853651
141MP0001943_abnormal_respiration0.66488313
142MP0005253_abnormal_eye_physiology0.64206406
143MP0001666_abnormal_nutrient_absorption0.64198403
144MP0000678_abnormal_parathyroid_gland0.63667145
145MP0002064_seizures0.63587993
146MP0001188_hyperpigmentation0.63226626
147MP0002109_abnormal_limb_morphology0.62918326
148MP0003984_embryonic_growth_retardation0.62466662
149MP0002088_abnormal_embryonic_growth/wei0.62299343
150MP0001756_abnormal_urination0.61400065
151MP0001664_abnormal_digestion0.60169346
152MP0001968_abnormal_touch/_nociception0.56836107
153MP0005220_abnormal_exocrine_pancreas0.53319910
154MP0009672_abnormal_birth_weight0.49530506
155MP0003866_abnormal_defecation0.47444803
156MP0005389_reproductive_system_phenotype0.47392857
157MP0005167_abnormal_blood-brain_barrier0.45989319
158MP0009046_muscle_twitch0.45577206
159MP0002928_abnormal_bile_duct0.45504986
160MP0000759_abnormal_skeletal_muscle0.45137788
161MP0001270_distended_abdomen0.43604159
162MP0005083_abnormal_biliary_tract0.42935892
163MP0004185_abnormal_adipocyte_glucose0.42738775

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)7.26617260
2Anomalous pulmonary venous return (HP:0010772)5.79280852
3Concave nail (HP:0001598)5.46560579
4Abnormality of the intervertebral disk (HP:0005108)5.25734615
5Abnormality of the pulmonary veins (HP:0011718)5.06299297
6Myokymia (HP:0002411)4.38800692
7Torticollis (HP:0000473)4.17519356
8Hemivertebrae (HP:0002937)3.98336471
9Arthropathy (HP:0003040)3.90094721
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.84004582
11Short 4th metacarpal (HP:0010044)3.84004582
12Oligodactyly (HP:0012165)3.74577114
13Self-mutilation (HP:0000742)3.59155903
14Vertebral arch anomaly (HP:0008438)3.49338771
15Nonprogressive disorder (HP:0003680)3.42294308
16Action tremor (HP:0002345)3.39491501
17Focal dystonia (HP:0004373)3.37681815
18Craniofacial dystonia (HP:0012179)3.31318238
19Septo-optic dysplasia (HP:0100842)3.29935839
20Orthostatic hypotension (HP:0001278)3.28724495
21Autoamputation (HP:0001218)3.28553666
22Recurrent corneal erosions (HP:0000495)3.13803874
23Aplasia/Hypoplasia of the patella (HP:0006498)3.03661428
24Spina bifida occulta (HP:0003298)3.00634406
25Type 2 muscle fiber atrophy (HP:0003554)3.00439582
26High anterior hairline (HP:0009890)2.99355138
27Poor suck (HP:0002033)2.99122567
28Coronal craniosynostosis (HP:0004440)2.97753407
29Fetal akinesia sequence (HP:0001989)2.96540926
30Renal duplication (HP:0000075)2.94223064
31Amblyopia (HP:0000646)2.94047389
32Mesomelia (HP:0003027)2.89713668
33Oligodactyly (hands) (HP:0001180)2.88166339
34Abnormality of the 4th metacarpal (HP:0010012)2.84474252
35Prominent occiput (HP:0000269)2.80488152
36Abnormal number of incisors (HP:0011064)2.79291894
37Intestinal atresia (HP:0011100)2.77231719
38Abnormality of the lower motor neuron (HP:0002366)2.75533379
39Maternal diabetes (HP:0009800)2.75510949
40Facial hemangioma (HP:0000329)2.69717945
41Patellar aplasia (HP:0006443)2.68224066
42Elfin facies (HP:0004428)2.64470783
43Muscle fiber atrophy (HP:0100295)2.62659603
44Neonatal hypoglycemia (HP:0001998)2.61792743
45Hepatoblastoma (HP:0002884)2.61095511
46Diastasis recti (HP:0001540)2.61083338
47Aqueductal stenosis (HP:0002410)2.59831319
48Abnormality of the diencephalon (HP:0010662)2.53545554
49Focal motor seizures (HP:0011153)2.53328427
50Intention tremor (HP:0002080)2.52234591
51Abnormal pancreas size (HP:0012094)2.51493154
52Abdominal situs inversus (HP:0003363)2.48999066
53Abnormality of abdominal situs (HP:0011620)2.48999066
54Vertebral fusion (HP:0002948)2.47352752
55Neoplasm of the adrenal cortex (HP:0100641)2.47258786
56Abnormality of the phalanges of the hallux (HP:0010057)2.45764390
57Broad thumb (HP:0011304)2.45427022
58Bronchomalacia (HP:0002780)2.45138655
59Sex reversal (HP:0012245)2.44717495
60Abnormal sex determination (HP:0012244)2.44717495
61Meningocele (HP:0002435)2.41115447
62Anhidrosis (HP:0000970)2.40086940
63Thyroid carcinoma (HP:0002890)2.37380154
64Megalencephaly (HP:0001355)2.37351881
65Depression (HP:0000716)2.35980041
66Supernumerary spleens (HP:0009799)2.35937958
67Anophthalmia (HP:0000528)2.35252798
68Adactyly (HP:0009776)2.34297535
69Broad toe (HP:0001837)2.34191232
70Impaired vibration sensation in the lower limbs (HP:0002166)2.31857680
71Abnormality of dental color (HP:0011073)2.31692601
72Esophageal atresia (HP:0002032)2.28892391
73Deep palmar crease (HP:0006191)2.28847560
74Congenital malformation of the right heart (HP:0011723)2.28203410
75Double outlet right ventricle (HP:0001719)2.28203410
76Focal seizures (HP:0007359)2.27154925
77Chin dimple (HP:0010751)2.27017323
78Hypoplasia of the brainstem (HP:0002365)2.26579087
79Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26579087
80Shallow orbits (HP:0000586)2.23924257
81Abnormality of pain sensation (HP:0010832)2.22654274
82Impaired pain sensation (HP:0007328)2.22654274
83Alacrima (HP:0000522)2.21674710
84Abnormality of the parathyroid morphology (HP:0011766)2.20152383
85Disproportionate short-trunk short stature (HP:0003521)2.19694884
86Severe visual impairment (HP:0001141)2.19559184
87Midline defect of the nose (HP:0004122)2.18988837
88Abnormality of the septum pellucidum (HP:0007375)2.11645578
89Impulsivity (HP:0100710)2.10610045
90Drooling (HP:0002307)2.10288270
91Natal tooth (HP:0000695)2.10213785
92Absent septum pellucidum (HP:0001331)2.09999931
93Horseshoe kidney (HP:0000085)2.09556989
94Supernumerary ribs (HP:0005815)2.06743145
95Partial agenesis of the corpus callosum (HP:0001338)2.06654945
96Fatigable weakness (HP:0003473)2.06602657
97Abnormality of the neuromuscular junction (HP:0003398)2.06602657
98Congenital diaphragmatic hernia (HP:0000776)2.06441966
99Atresia of the external auditory canal (HP:0000413)2.06424832
100Abnormality of the labia minora (HP:0012880)2.06365960
101Broad phalanges of the hand (HP:0009768)2.05738337
102Broad hallux (HP:0010055)2.04842603
103Incomplete penetrance (HP:0003829)2.02830905
104Large earlobe (HP:0009748)2.02529055
105Ridged nail (HP:0001807)2.01397946
106Increased nuchal translucency (HP:0010880)1.99782113
107Decreased lacrimation (HP:0000633)1.99473718
108Broad metatarsal (HP:0001783)1.99024473
109Hypoplastic female external genitalia (HP:0012815)1.98873482
110Optic nerve hypoplasia (HP:0000609)1.98825564
111Hypoplastic pelvis (HP:0008839)1.98038349
112Metaphyseal dysplasia (HP:0100255)1.97292760
113Dysautonomia (HP:0002459)1.97130406
114Abnormality of the corticospinal tract (HP:0002492)1.95985624
115Short middle phalanx of the 5th finger (HP:0004220)1.95700301
116Cerebral aneurysm (HP:0004944)1.95689003
117Broad finger (HP:0001500)1.95675000
118Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.95559981
119Abnormality of the odontoid process (HP:0003310)1.94279127
120Generalized hypotonia (HP:0001290)1.93823109
121Difficulty running (HP:0009046)1.93622573
122Selective tooth agenesis (HP:0001592)1.92561142
123Stenosis of the external auditory canal (HP:0000402)1.92284913
124Excessive salivation (HP:0003781)1.91066216
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90792509
126Hypoplastic toenails (HP:0001800)1.89419654
127Weak cry (HP:0001612)1.87254129
128Severe short stature (HP:0003510)1.87134816
129Pointed chin (HP:0000307)1.86402863
130Polymicrogyria (HP:0002126)1.86384014
131Adenoma sebaceum (HP:0009720)1.83850652
132Angiofibromas (HP:0010615)1.83850652
133Short thorax (HP:0010306)1.83620933
134Synostosis of carpal bones (HP:0005048)1.83610290
135Neonatal short-limb short stature (HP:0008921)1.83311999
136Obsessive-compulsive behavior (HP:0000722)1.83227094
137Aplasia of the musculature (HP:0100854)1.82407763
138Leiomyosarcoma (HP:0100243)1.82224885
139Uterine leiomyosarcoma (HP:0002891)1.82224885
140Supernumerary bones of the axial skeleton (HP:0009144)1.81549815
141Short nail (HP:0001799)1.80893225
142Down-sloping shoulders (HP:0200021)1.80020138
143Pendular nystagmus (HP:0012043)1.79731111
144Hypoplastic labia majora (HP:0000059)1.78652274
145Abnormality of the antihelix (HP:0009738)1.76065457
146Labial hypoplasia (HP:0000066)1.75865766
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75766044
148Neonatal onset (HP:0003623)1.74801170
149Wrist flexion contracture (HP:0001239)1.74011047
150Overriding aorta (HP:0002623)1.73516412
151Bladder neoplasm (HP:0009725)1.72027708
152Bladder carcinoma (HP:0002862)1.72027708
153Adrenal hypoplasia (HP:0000835)1.71140850
154Arnold-Chiari malformation (HP:0002308)1.70711111
155Split foot (HP:0001839)1.70106588
156Broad phalanx (HP:0006009)1.69290955
157Carpal bone hypoplasia (HP:0001498)1.68934942
158Abnormality of the aortic arch (HP:0012303)1.68468102
159Turricephaly (HP:0000262)1.68268454
160Carpal synostosis (HP:0009702)1.67974931
161Cutis marmorata (HP:0000965)1.66179133
162Shawl scrotum (HP:0000049)1.66121592
163Hypoglycemic seizures (HP:0002173)1.66057900
164Anxiety (HP:0000739)1.65959449
165Renal hypoplasia (HP:0000089)1.65886873
166Breast hypoplasia (HP:0003187)1.65831428
167Coarctation of aorta (HP:0001680)1.65090247
168Redundant skin (HP:0001582)1.64421724
169Abnormality of the labia (HP:0000058)1.63181178
170Insomnia (HP:0100785)1.63098107
171Popliteal pterygium (HP:0009756)1.61842295
172Polyphagia (HP:0002591)1.61522954
173Ankle clonus (HP:0011448)1.57242432
174Retinal dysplasia (HP:0007973)1.57053235
175Spinal muscular atrophy (HP:0007269)1.55249661
176Emotional lability (HP:0000712)1.55003018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK16.80061958
2TLK15.39689531
3MATK5.02321803
4EPHB24.52433918
5MKNK14.01546947
6FGFR23.18316388
7BUB13.17044984
8ERBB32.94661365
9MAP3K102.91216654
10PKN12.68064154
11TYRO32.56297509
12UHMK12.53680622
13SRPK12.50317994
14ICK2.37152994
15MKNK22.36853329
16CDK122.32569217
17ADRBK22.29799628
18CDC72.21189227
19MARK22.15164881
20MAP2K72.08955503
21KSR11.85540827
22MAP3K41.76882094
23CDK191.74797078
24BRD41.72177802
25NTRK31.67012541
26NME11.66939906
27MAP3K71.66555402
28NEK21.62925926
29YES11.52115355
30DYRK31.47460423
31ERBB21.44210944
32BCR1.42291055
33TRIB31.41679923
34RPS6KA21.37654894
35CDK51.35388540
36FGFR41.35156204
37LATS11.35031211
38BRSK11.29842543
39CDK81.29454876
40PDGFRA1.29303821
41CAMK11.28501304
42PBK1.27077277
43PRKD21.24533078
44CSF1R1.24271294
45NTRK21.23719906
46STK161.23322665
47DAPK21.23227736
48TNIK1.21368034
49CASK1.19764489
50DYRK1B1.18804752
51CCNB11.18602228
52CAMKK11.14488231
53LRRK21.13311335
54PKN21.12678456
55CDK71.11362758
56DYRK21.10117163
57GRK11.03993799
58PRKCG1.03855907
59TTK1.01343505
60MARK11.00754993
61MAP3K60.98433219
62LIMK10.96592930
63FGFR10.96284178
64MAP2K40.95499539
65PRKCZ0.95097802
66AURKA0.95054306
67EPHA40.94114189
68CAMK1G0.88151195
69CSNK1G20.87071021
70CSNK1G30.86862468
71TRIM280.86717233
72LMTK20.86416829
73CSNK1A1L0.84542639
74PASK0.82562624
75MAP3K110.81870856
76AURKB0.81070900
77STK110.80574519
78PRKAA10.76609133
79PLK30.75839580
80ATR0.73729305
81INSRR0.72064871
82FES0.71754258
83NEK10.70991734
84CDC42BPA0.67908969
85MAPK110.67185409
86DYRK1A0.66520889
87CSNK1E0.66015077
88SGK2230.65873251
89SGK4940.65873251
90CHEK10.63697570
91FGFR30.62887168
92TAOK10.61963056
93PRKD10.61198632
94CAMK1D0.59361807
95TESK20.58148292
96LATS20.58132290
97PTK60.57958757
98CDK10.56645974
99EEF2K0.55767526
100MELK0.55462850
101CDK20.54979652
102PLK10.53394739
103TGFBR10.53073632
104CDK11A0.52760134
105PRKCH0.51886869
106ADRBK10.51574554
107PRKAA20.50184729
108PLK40.47895426
109CDK180.47151884
110RET0.46256799
111CDK150.46019521
112CHEK20.44136615
113TIE10.42943272
114PAK60.42760970
115VRK10.41288040
116SIK30.40881119
117DDR20.40865873
118BCKDK0.40495157
119INSR0.40436274
120CDK60.40242771
121CSNK1D0.40230538
122PIK3CG0.40128498
123PRKCD0.39834998
124CAMK2G0.39210188
125DAPK30.38907046
126MTOR0.38194972
127SIK20.37471242
128CSNK1G10.37435963
129CDK140.37132031
130ROCK20.37105477
131ILK0.35757364
132CLK10.35515048
133IGF1R0.35401023
134ATM0.35383667
135RPS6KB20.34826426
136HIPK20.34062462
137PRPF4B0.33694420
138GSK3B0.33015205
139CSNK2A20.32765451
140MINK10.32304897
141PRKDC0.31649477
142SGK20.30785985
143PAK30.30524115
144AKT10.30522794
145PNCK0.30099845
146PRKACA0.29435068
147DMPK0.29180246
148GRK50.29115203
149RPS6KA10.28754141
150IRAK10.28716391
151CAMK40.27916373
152CAMK2B0.27470950
153EGFR0.27331953
154MAPK90.27001395
155AKT20.25674084
156MAPK140.25477844
157IRAK20.24529129

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.18511149
2Basal cell carcinoma_Homo sapiens_hsa052174.06653472
3Notch signaling pathway_Homo sapiens_hsa043303.99933300
4Spliceosome_Homo sapiens_hsa030403.91534496
5Cocaine addiction_Homo sapiens_hsa050303.46183855
6Hedgehog signaling pathway_Homo sapiens_hsa043402.96172379
7Synaptic vesicle cycle_Homo sapiens_hsa047212.93428143
8Cell cycle_Homo sapiens_hsa041102.84291635
9DNA replication_Homo sapiens_hsa030302.78719153
10Hippo signaling pathway_Homo sapiens_hsa043902.59612231
11Nicotine addiction_Homo sapiens_hsa050332.56680936
12Ribosome_Homo sapiens_hsa030102.43669213
13* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.30185983
14Homologous recombination_Homo sapiens_hsa034402.27949286
15mRNA surveillance pathway_Homo sapiens_hsa030152.27062165
16Base excision repair_Homo sapiens_hsa034102.24495121
17Mismatch repair_Homo sapiens_hsa034302.21447466
18One carbon pool by folate_Homo sapiens_hsa006702.14106786
19Sulfur relay system_Homo sapiens_hsa041222.03772293
20Bladder cancer_Homo sapiens_hsa052192.02905971
21Axon guidance_Homo sapiens_hsa043602.00872179
22Non-homologous end-joining_Homo sapiens_hsa034502.00434083
23Melanogenesis_Homo sapiens_hsa049161.91620635
24RNA transport_Homo sapiens_hsa030131.86712838
25Cardiac muscle contraction_Homo sapiens_hsa042601.77968413
26Wnt signaling pathway_Homo sapiens_hsa043101.75054646
27Parkinsons disease_Homo sapiens_hsa050121.64187833
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.58554085
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53947721
30MicroRNAs in cancer_Homo sapiens_hsa052061.46289935
31Chronic myeloid leukemia_Homo sapiens_hsa052201.43091971
32Morphine addiction_Homo sapiens_hsa050321.38567265
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37887828
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34462346
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32866248
36HTLV-I infection_Homo sapiens_hsa051661.31762008
37Type II diabetes mellitus_Homo sapiens_hsa049301.30632111
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30351479
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29987338
40RNA polymerase_Homo sapiens_hsa030201.25906033
41Non-small cell lung cancer_Homo sapiens_hsa052231.24603524
42Circadian entrainment_Homo sapiens_hsa047131.23735365
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.22688909
44cAMP signaling pathway_Homo sapiens_hsa040241.22267315
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20072241
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18748703
47Colorectal cancer_Homo sapiens_hsa052101.17939889
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14888686
49Glioma_Homo sapiens_hsa052141.12546123
50Nucleotide excision repair_Homo sapiens_hsa034201.11325478
51Endometrial cancer_Homo sapiens_hsa052131.10980555
52Renal cell carcinoma_Homo sapiens_hsa052111.09174338
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06730919
54p53 signaling pathway_Homo sapiens_hsa041151.02570712
55Proteoglycans in cancer_Homo sapiens_hsa052051.00813080
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00530962
57ErbB signaling pathway_Homo sapiens_hsa040120.96560700
58Pathways in cancer_Homo sapiens_hsa052000.93898352
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93036328
60Gastric acid secretion_Homo sapiens_hsa049710.92332078
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91504150
62Choline metabolism in cancer_Homo sapiens_hsa052310.88327814
63Oxytocin signaling pathway_Homo sapiens_hsa049210.87802960
64Tight junction_Homo sapiens_hsa045300.86988558
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85815982
66Oocyte meiosis_Homo sapiens_hsa041140.84241031
67Pyrimidine metabolism_Homo sapiens_hsa002400.84168639
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.83845659
69Adherens junction_Homo sapiens_hsa045200.83511710
70TGF-beta signaling pathway_Homo sapiens_hsa043500.82922314
71Insulin secretion_Homo sapiens_hsa049110.82644895
72Inositol phosphate metabolism_Homo sapiens_hsa005620.82236603
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79245195
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76789750
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.75658011
76VEGF signaling pathway_Homo sapiens_hsa043700.75132228
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74438977
78Steroid biosynthesis_Homo sapiens_hsa001000.73933870
79Dilated cardiomyopathy_Homo sapiens_hsa054140.73171855
80Oxidative phosphorylation_Homo sapiens_hsa001900.72770862
81Alcoholism_Homo sapiens_hsa050340.72601890
82Gap junction_Homo sapiens_hsa045400.72272517
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72209628
84Ether lipid metabolism_Homo sapiens_hsa005650.71103128
85FoxO signaling pathway_Homo sapiens_hsa040680.70606420
86Melanoma_Homo sapiens_hsa052180.70223520
87Thyroid cancer_Homo sapiens_hsa052160.70127212
88Phototransduction_Homo sapiens_hsa047440.68472443
89RNA degradation_Homo sapiens_hsa030180.66727665
90Endocytosis_Homo sapiens_hsa041440.66147401
91Systemic lupus erythematosus_Homo sapiens_hsa053220.65027222
92AMPK signaling pathway_Homo sapiens_hsa041520.63224534
93Salivary secretion_Homo sapiens_hsa049700.63024718
94Starch and sucrose metabolism_Homo sapiens_hsa005000.61699156
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60225984
96Olfactory transduction_Homo sapiens_hsa047400.59782964
97Calcium signaling pathway_Homo sapiens_hsa040200.59574434
98Lysine degradation_Homo sapiens_hsa003100.58912635
99Fatty acid metabolism_Homo sapiens_hsa012120.58891881
100Circadian rhythm_Homo sapiens_hsa047100.57620117
101Epstein-Barr virus infection_Homo sapiens_hsa051690.57552733
102Pancreatic cancer_Homo sapiens_hsa052120.57540647
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56655215
104Estrogen signaling pathway_Homo sapiens_hsa049150.55379025
105Galactose metabolism_Homo sapiens_hsa000520.54892750
106Prostate cancer_Homo sapiens_hsa052150.53828785
107Fanconi anemia pathway_Homo sapiens_hsa034600.53700377
108Herpes simplex infection_Homo sapiens_hsa051680.53146870
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52483443
110Small cell lung cancer_Homo sapiens_hsa052220.52377701
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.52192927
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50454059
113Rap1 signaling pathway_Homo sapiens_hsa040150.49273411
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48279278
115Ras signaling pathway_Homo sapiens_hsa040140.47682150
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47632541
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47150913
118Pancreatic secretion_Homo sapiens_hsa049720.46063962
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44467341
120Serotonergic synapse_Homo sapiens_hsa047260.44273895
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44079800
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43414822
123Salmonella infection_Homo sapiens_hsa051320.41120164
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40843741
125Glutamatergic synapse_Homo sapiens_hsa047240.39544197
126Viral carcinogenesis_Homo sapiens_hsa052030.38968500
127Dopaminergic synapse_Homo sapiens_hsa047280.37994318
128Alzheimers disease_Homo sapiens_hsa050100.37632640
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37376280
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36942725
131Hepatitis B_Homo sapiens_hsa051610.36714320
132Prolactin signaling pathway_Homo sapiens_hsa049170.36624606
133Insulin signaling pathway_Homo sapiens_hsa049100.36263360
134Huntingtons disease_Homo sapiens_hsa050160.35969035
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.35668238
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33755921
137Basal transcription factors_Homo sapiens_hsa030220.33102480
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.32926357
139Long-term depression_Homo sapiens_hsa047300.31196822
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30346556
141Taste transduction_Homo sapiens_hsa047420.27920739
142Butanoate metabolism_Homo sapiens_hsa006500.26951924
143Cholinergic synapse_Homo sapiens_hsa047250.26523221
144Long-term potentiation_Homo sapiens_hsa047200.26417504
145Dorso-ventral axis formation_Homo sapiens_hsa043200.26274893
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26256992
147GABAergic synapse_Homo sapiens_hsa047270.25872784
148Glucagon signaling pathway_Homo sapiens_hsa049220.25862483
149Proteasome_Homo sapiens_hsa030500.25361552
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24211154
151HIF-1 signaling pathway_Homo sapiens_hsa040660.23090406
152MAPK signaling pathway_Homo sapiens_hsa040100.20938896

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