NEUROD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.14266163
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.66195820
3vocalization behavior (GO:0071625)5.55794080
4protein localization to synapse (GO:0035418)5.48598936
5neuron cell-cell adhesion (GO:0007158)5.34694707
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.30950171
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20427161
8neuron recognition (GO:0008038)5.16087163
9positive regulation of synapse maturation (GO:0090129)5.08233014
10regulation of timing of cell differentiation (GO:0048505)5.07806164
11glutamate receptor signaling pathway (GO:0007215)5.06099633
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05687389
13regulation of glutamate receptor signaling pathway (GO:1900449)5.04585112
14synaptic vesicle exocytosis (GO:0016079)5.03555757
15glial cell proliferation (GO:0014009)4.96501395
16axonal fasciculation (GO:0007413)4.94183738
17keratinocyte development (GO:0003334)4.86535271
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.81115774
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69776728
20regulation of collateral sprouting (GO:0048670)4.69346043
21presynaptic membrane assembly (GO:0097105)4.64854173
22glutamate secretion (GO:0014047)4.61058513
23exploration behavior (GO:0035640)4.58579042
24synaptic transmission, glutamatergic (GO:0035249)4.57332106
25locomotory exploration behavior (GO:0035641)4.54260451
26regulation of development, heterochronic (GO:0040034)4.51981397
27presynaptic membrane organization (GO:0097090)4.43821836
28postsynaptic membrane organization (GO:0001941)4.41182683
29cardiac ventricle formation (GO:0003211)4.37741878
30neurotransmitter-gated ion channel clustering (GO:0072578)4.37539611
31neural tube formation (GO:0001841)4.37497131
32regulation of synaptic vesicle exocytosis (GO:2000300)4.37073658
33neuron-neuron synaptic transmission (GO:0007270)4.34303498
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31561641
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28396669
36central nervous system projection neuron axonogenesis (GO:0021952)4.27578608
37positive regulation of neurotransmitter secretion (GO:0001956)4.22015051
38regulation of synapse maturation (GO:0090128)4.18898797
39sympathetic nervous system development (GO:0048485)4.16971916
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.10093558
41regulation of neuronal synaptic plasticity (GO:0048168)4.08318004
42regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08228607
43negative regulation of axon extension (GO:0030517)4.08006109
44regulation of dendritic spine morphogenesis (GO:0061001)4.07740946
45spinal cord development (GO:0021510)4.06730275
46olfactory bulb development (GO:0021772)4.06664791
47hindbrain development (GO:0030902)4.04196110
48behavioral fear response (GO:0001662)4.03907804
49behavioral defense response (GO:0002209)4.03907804
50regulation of synaptic vesicle transport (GO:1902803)3.98275948
51cardiac chamber formation (GO:0003207)3.98083719
52regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.95667257
53long-term synaptic potentiation (GO:0060291)3.95276304
54cerebral cortex radially oriented cell migration (GO:0021799)3.94641738
55establishment of mitochondrion localization (GO:0051654)3.92106536
56synaptic vesicle endocytosis (GO:0048488)3.91313251
57layer formation in cerebral cortex (GO:0021819)3.89712371
58regulation of postsynaptic membrane potential (GO:0060078)3.87671084
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.87465079
60negative regulation of astrocyte differentiation (GO:0048712)3.84690525
61synaptic vesicle maturation (GO:0016188)3.80596429
62regulation of synaptic plasticity (GO:0048167)3.79139895
63dendritic spine morphogenesis (GO:0060997)3.78919261
64fear response (GO:0042596)3.78813649
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76669483
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.76488352
67regulation of synapse structural plasticity (GO:0051823)3.71482524
68positive regulation of male gonad development (GO:2000020)3.71359030
69forebrain neuron differentiation (GO:0021879)3.68746788
70negative regulation of protein oligomerization (GO:0032460)3.68445070
71lung secretory cell differentiation (GO:0061140)3.66042491
72long-term memory (GO:0007616)3.65710947
73pyrimidine nucleobase catabolic process (GO:0006208)3.64990484
74mitochondrial genome maintenance (GO:0000002)3.63767661
75regulation of glutamate secretion (GO:0014048)3.62311494
76opioid receptor signaling pathway (GO:0038003)3.61893533
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.61890332
78cell migration in hindbrain (GO:0021535)3.57403666
79response to histamine (GO:0034776)3.56097241
80regulation of dendritic spine development (GO:0060998)3.56074103
81neuronal action potential propagation (GO:0019227)3.54425246
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.53054224
83mitochondrion transport along microtubule (GO:0047497)3.53054224
84innervation (GO:0060384)3.52589325
85regulation of female receptivity (GO:0045924)3.51999322
86negative regulation of translation, ncRNA-mediated (GO:0040033)3.49523667
87regulation of translation, ncRNA-mediated (GO:0045974)3.49523667
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.49523667
89positive regulation of membrane potential (GO:0045838)3.49437223
90dendritic spine organization (GO:0097061)3.45581688
91cerebellar granule cell differentiation (GO:0021707)3.43656156
92inositol phosphate catabolic process (GO:0071545)3.43464757
93central nervous system neuron axonogenesis (GO:0021955)3.42058028
94long-chain fatty acid biosynthetic process (GO:0042759)3.40319003
95regulation of male gonad development (GO:2000018)3.38612033
96cochlea development (GO:0090102)3.38210471
97neuronal ion channel clustering (GO:0045161)3.38119183
98nucleobase catabolic process (GO:0046113)3.37246059
99positive regulation of dendritic spine development (GO:0060999)3.34307006
100female mating behavior (GO:0060180)3.33187606
101neurotransmitter secretion (GO:0007269)3.32432206
102positive regulation of neurotransmitter transport (GO:0051590)3.28767625
103proline transport (GO:0015824)3.26211654
104learning (GO:0007612)3.24770250
105cornea development in camera-type eye (GO:0061303)3.23688844
106transmission of nerve impulse (GO:0019226)3.23068635
107regulation of vesicle fusion (GO:0031338)3.22402613
108dendrite development (GO:0016358)3.21885040
109negative regulation of axonogenesis (GO:0050771)3.21289986
110somite development (GO:0061053)3.21101414
111dendrite morphogenesis (GO:0048813)3.19883412
112regulation of synaptic transmission, glutamatergic (GO:0051966)3.19193543
113positive regulation of synapse assembly (GO:0051965)3.18706106
114long term synaptic depression (GO:0060292)3.16659975
115glycosphingolipid biosynthetic process (GO:0006688)3.16372593
116regulation of neurotransmitter secretion (GO:0046928)3.13490499
117negative regulation of stem cell proliferation (GO:2000647)3.13114042
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13072509
119acrosome reaction (GO:0007340)3.12291060
120axonogenesis (GO:0007409)3.11718876
121ephrin receptor signaling pathway (GO:0048013)3.10180949
122cerebral cortex cell migration (GO:0021795)3.10124162
123vesicle transport along microtubule (GO:0047496)3.09767662
124regulation of axon extension (GO:0030516)3.08446707
125protein K11-linked deubiquitination (GO:0035871)3.06123329
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04553570
127regulation of synapse organization (GO:0050807)3.04243869
128startle response (GO:0001964)3.03061320
129negative regulation of DNA binding (GO:0043392)3.02897065
130negative regulation of transcription regulatory region DNA binding (GO:2000678)3.02595633
131regulation of neuron projection regeneration (GO:0070570)3.01844941
132regulation of axon regeneration (GO:0048679)3.01844941
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99367331
134membrane depolarization (GO:0051899)2.99269743
135behavioral response to cocaine (GO:0048148)2.97263602
136axon extension (GO:0048675)2.96851768
137negative chemotaxis (GO:0050919)2.96521062
138synapse assembly (GO:0007416)2.95259697
139kidney morphogenesis (GO:0060993)2.93867164
140negative regulation of microtubule polymerization (GO:0031115)2.91698403
141retinal ganglion cell axon guidance (GO:0031290)2.91240125
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91033569
143organelle transport along microtubule (GO:0072384)2.91022325
144regulation of synaptic transmission (GO:0050804)2.90524751
145regulation of telomere maintenance (GO:0032204)2.89167477
146regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.87850233
147negative regulation of dendrite development (GO:2000171)2.87524141
148regulation of extent of cell growth (GO:0061387)2.84174804
149inner ear receptor stereocilium organization (GO:0060122)2.76827461
150stress granule assembly (GO:0034063)2.72293016
151membrane assembly (GO:0071709)2.69331322
152regulation of keratinocyte proliferation (GO:0010837)2.69029288
153regulation of axon guidance (GO:1902667)2.66691662
154regulation of axon extension involved in axon guidance (GO:0048841)2.63754390
155hippocampus development (GO:0021766)2.62867220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41838717
2GBX2_23144817_ChIP-Seq_PC3_Human4.47684996
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91707686
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15432695
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08142820
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87932489
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.84990624
8REST_21632747_ChIP-Seq_MESCs_Mouse2.69842337
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68862910
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57213248
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.51133549
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50768309
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50768309
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45464185
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43701855
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.32484219
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27295696
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.26998251
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26741544
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25550347
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24340200
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16910024
23TAF15_26573619_Chip-Seq_HEK293_Human2.16363993
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15111818
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.10330031
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.08506170
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04965832
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02271847
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96580745
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95769533
31AR_21572438_ChIP-Seq_LNCaP_Human1.93885607
32P300_19829295_ChIP-Seq_ESCs_Human1.92960906
33DROSHA_22980978_ChIP-Seq_HELA_Human1.89307760
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88765070
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83547748
36SMAD4_21799915_ChIP-Seq_A2780_Human1.83545829
37FUS_26573619_Chip-Seq_HEK293_Human1.82902243
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82680385
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81572332
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.77719938
41IGF1R_20145208_ChIP-Seq_DFB_Human1.75724268
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75650873
43ZNF274_21170338_ChIP-Seq_K562_Hela1.74367230
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73156647
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72708570
46VDR_22108803_ChIP-Seq_LS180_Human1.65672885
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.61249640
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56134759
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53868482
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53669846
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53391835
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53382249
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53309893
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52998750
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51097531
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48754381
57AR_25329375_ChIP-Seq_VCAP_Human1.48519504
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46277972
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45520921
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44400016
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38762646
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.35419216
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.32879017
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30717188
65* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30132881
66* CBP_20019798_ChIP-Seq_JUKART_Human1.30132881
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29971276
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28652437
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28067974
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24475073
71RNF2_27304074_Chip-Seq_NSC_Mouse1.23997607
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.23053160
73STAT3_23295773_ChIP-Seq_U87_Human1.22000686
74* TP53_18474530_ChIP-ChIP_U2OS_Human1.20927118
75TP53_16413492_ChIP-PET_HCT116_Human1.20868853
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20410950
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.18383583
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18360730
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18135434
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18135434
81* TCF4_23295773_ChIP-Seq_U87_Human1.17978670
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.17814885
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.17041411
84* JUN_21703547_ChIP-Seq_K562_Human1.16065431
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.14768412
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13582375
87ER_23166858_ChIP-Seq_MCF-7_Human1.13283116
88RUNX2_22187159_ChIP-Seq_PCA_Human1.12190732
89AR_19668381_ChIP-Seq_PC3_Human1.11732144
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09870624
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.09805650
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09602858
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.09503564
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08927716
95RXR_22108803_ChIP-Seq_LS180_Human1.08078911
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.07965124
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06533989
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06376387
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05554736
100AHR_22903824_ChIP-Seq_MCF-7_Human1.05041169
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04904581
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04577695
103SOX9_26525672_Chip-Seq_HEART_Mouse1.04486573
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04461919
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04368396
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.02580997
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00938708
108BCAT_22108803_ChIP-Seq_LS180_Human1.00672686
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99935039
110* TCF4_22108803_ChIP-Seq_LS180_Human0.99486030
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99082525
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99010138
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98265884
114KDM2B_26808549_Chip-Seq_REH_Human0.98022900
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97936154
116P53_22387025_ChIP-Seq_ESCs_Mouse0.95631333
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94600388
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.93986044
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93860306
120EWS_26573619_Chip-Seq_HEK293_Human0.92194459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.57068756
2MP0003880_abnormal_central_pattern6.30210148
3* MP0003635_abnormal_synaptic_transmissio4.08263169
4MP0004270_analgesia3.94088221
5MP0002063_abnormal_learning/memory/cond3.63673357
6MP0009745_abnormal_behavioral_response3.41033695
7MP0001968_abnormal_touch/_nociception3.24622103
8MP0002736_abnormal_nociception_after3.06102313
9MP0002064_seizures2.95673870
10MP0002572_abnormal_emotion/affect_behav2.90306262
11MP0000778_abnormal_nervous_system2.81630546
12MP0000569_abnormal_digit_pigmentation2.59708998
13MP0002735_abnormal_chemical_nociception2.56980544
14MP0000516_abnormal_urinary_system2.49155596
15MP0005367_renal/urinary_system_phenotyp2.49155596
16MP0001440_abnormal_grooming_behavior2.47888069
17MP0002734_abnormal_mechanical_nocicepti2.39661572
18MP0002272_abnormal_nervous_system2.31176127
19MP0009780_abnormal_chondrocyte_physiolo2.28302233
20MP0001486_abnormal_startle_reflex2.24477066
21MP0005423_abnormal_somatic_nervous2.23210445
22MP0001501_abnormal_sleep_pattern2.16634379
23MP0009046_muscle_twitch2.11075409
24MP0002184_abnormal_innervation2.01278998
25MP0006276_abnormal_autonomic_nervous1.94065228
26MP0001188_hyperpigmentation1.92694134
27MP0002067_abnormal_sensory_capabilities1.92314667
28MP0003787_abnormal_imprinting1.91661471
29MP0002733_abnormal_thermal_nociception1.86811949
30MP0003329_amyloid_beta_deposits1.81179752
31MP0004811_abnormal_neuron_physiology1.80668495
32MP0008877_abnormal_DNA_methylation1.80473766
33MP0003718_maternal_effect1.78377365
34MP0000534_abnormal_ureter_morphology1.77780229
35MP0001970_abnormal_pain_threshold1.73903526
36MP0002557_abnormal_social/conspecific_i1.71637361
37MP0000566_synostosis1.71237134
38MP0002837_dystrophic_cardiac_calcinosis1.70088442
39MP0005386_behavior/neurological_phenoty1.68843184
40MP0004924_abnormal_behavior1.68843184
41MP0001529_abnormal_vocalization1.52513451
42MP0003879_abnormal_hair_cell1.50830783
43MP0000955_abnormal_spinal_cord1.50494842
44MP0006292_abnormal_olfactory_placode1.43200710
45MP0001905_abnormal_dopamine_level1.42867379
46MP0002882_abnormal_neuron_morphology1.40811674
47MP0004885_abnormal_endolymph1.38005382
48MP0003385_abnormal_body_wall1.37954437
49MP0004858_abnormal_nervous_system1.37834736
50MP0002066_abnormal_motor_capabilities/c1.36090991
51MP0001984_abnormal_olfaction1.35130071
52MP0009053_abnormal_anal_canal1.34786372
53MP0008569_lethality_at_weaning1.32111736
54MP0005409_darkened_coat_color1.28879572
55MP0002909_abnormal_adrenal_gland1.27294557
56MP0002876_abnormal_thyroid_physiology1.25772432
57MP0003121_genomic_imprinting1.24639249
58MP0004043_abnormal_pH_regulation1.24166856
59MP0002152_abnormal_brain_morphology1.22913968
60MP0005646_abnormal_pituitary_gland1.19676820
61MP0006072_abnormal_retinal_apoptosis1.16247029
62MP0001502_abnormal_circadian_rhythm1.12776745
63MP0003633_abnormal_nervous_system1.09452850
64MP0000751_myopathy1.04746085
65MP0002822_catalepsy1.04409630
66MP0009379_abnormal_foot_pigmentation1.03538194
67MP0005645_abnormal_hypothalamus_physiol1.01243464
68MP0000647_abnormal_sebaceous_gland1.01014985
69MP0003631_nervous_system_phenotype0.99617830
70MP0002234_abnormal_pharynx_morphology0.99556034
71MP0000631_abnormal_neuroendocrine_gland0.99057404
72MP0005187_abnormal_penis_morphology0.97591066
73MP0002233_abnormal_nose_morphology0.96898091
74MP0004484_altered_response_of0.96136111
75MP0005394_taste/olfaction_phenotype0.94165259
76MP0005499_abnormal_olfactory_system0.94165259
77MP0003755_abnormal_palate_morphology0.93276528
78MP0003942_abnormal_urinary_system0.92291097
79MP0000537_abnormal_urethra_morphology0.91957444
80MP0001963_abnormal_hearing_physiology0.90211816
81MP0002069_abnormal_eating/drinking_beha0.89653797
82MP0004510_myositis0.88939426
83MP0010386_abnormal_urinary_bladder0.86626879
84MP0008875_abnormal_xenobiotic_pharmacok0.86263542
85MP0002081_perinatal_lethality0.84009208
86MP0000015_abnormal_ear_pigmentation0.83540656
87MP0004145_abnormal_muscle_electrophysio0.82374321
88MP0004142_abnormal_muscle_tone0.81863452
89MP0004085_abnormal_heartbeat0.81118719
90MP0004742_abnormal_vestibular_system0.81095780
91MP0003861_abnormal_nervous_system0.80457239
92MP0005535_abnormal_body_temperature0.78246179
93MP0005174_abnormal_tail_pigmentation0.78222678
94MP0002752_abnormal_somatic_nervous0.78220778
95MP0005395_other_phenotype0.77013712
96MP0008058_abnormal_DNA_repair0.76389211
97MP0000604_amyloidosis0.75862579
98MP0002229_neurodegeneration0.75523417
99MP0005253_abnormal_eye_physiology0.75170262
100MP0001299_abnormal_eye_distance/0.74811813
101MP0005551_abnormal_eye_electrophysiolog0.74659221
102MP0005195_abnormal_posterior_eye0.74588681
103MP0005171_absent_coat_pigmentation0.74520013
104MP0002938_white_spotting0.74358312
105MP0003935_abnormal_craniofacial_develop0.74346930
106MP0001177_atelectasis0.73855345
107MP0008770_decreased_survivor_rate0.73773139
108MP0004215_abnormal_myocardial_fiber0.73374557
109MP0002102_abnormal_ear_morphology0.73123072
110MP0008874_decreased_physiological_sensi0.73054887
111MP0000026_abnormal_inner_ear0.72891656
112MP0000538_abnormal_urinary_bladder0.72417623
113MP0003122_maternal_imprinting0.71405715
114MP0001664_abnormal_digestion0.70123905
115MP0010768_mortality/aging0.69514281
116MP0003632_abnormal_nervous_system0.68279164
117MP0003698_abnormal_male_reproductive0.67353285
118MP0003634_abnormal_glial_cell0.67140291
119MP0008872_abnormal_physiological_respon0.64651945
120MP0003938_abnormal_ear_development0.62971356
121MP0003119_abnormal_digestive_system0.60881374
122MP0004233_abnormal_muscle_weight0.58010560
123MP0001485_abnormal_pinna_reflex0.55673187
124MP0002751_abnormal_autonomic_nervous0.52844959
125MP0008789_abnormal_olfactory_epithelium0.52423508
126MP0010769_abnormal_survival0.52064709
127MP0003137_abnormal_impulse_conducting0.51986917
128MP0001943_abnormal_respiration0.51917620
129MP0010770_preweaning_lethality0.51904593
130MP0002082_postnatal_lethality0.51904593
131MP0000681_abnormal_thyroid_gland0.50837690

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.21075854
2Abnormality of the labia minora (HP:0012880)6.56422480
3Hyperventilation (HP:0002883)6.03150840
4Myokymia (HP:0002411)5.68705722
5Epileptic encephalopathy (HP:0200134)5.44569612
6Focal seizures (HP:0007359)5.34280006
7Visual hallucinations (HP:0002367)5.10509489
8Atonic seizures (HP:0010819)4.45458430
9Febrile seizures (HP:0002373)4.21994049
10Broad-based gait (HP:0002136)4.20731757
11Absence seizures (HP:0002121)3.98078857
12Cerebral inclusion bodies (HP:0100314)3.95635685
13Amblyopia (HP:0000646)3.91456913
14Excessive salivation (HP:0003781)3.90272645
15Drooling (HP:0002307)3.90272645
16Progressive cerebellar ataxia (HP:0002073)3.88541042
17Dialeptic seizures (HP:0011146)3.74235773
18Generalized tonic-clonic seizures (HP:0002069)3.65496969
19Aplasia/Hypoplasia of the sternum (HP:0006714)3.38035024
20Epileptiform EEG discharges (HP:0011182)3.27239586
21Absent speech (HP:0001344)3.25245655
22Supranuclear gaze palsy (HP:0000605)3.21013193
23Tented upper lip vermilion (HP:0010804)3.15907905
24Poor eye contact (HP:0000817)3.13778449
25Hepatoblastoma (HP:0002884)3.11885070
26Neurofibrillary tangles (HP:0002185)3.07811716
27Impaired vibration sensation in the lower limbs (HP:0002166)3.05904253
28Protruding tongue (HP:0010808)2.95534289
29Amyotrophic lateral sclerosis (HP:0007354)2.92022610
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91005096
31Short 4th metacarpal (HP:0010044)2.91005096
32EEG with generalized epileptiform discharges (HP:0011198)2.88615595
33Abnormality of binocular vision (HP:0011514)2.88448415
34Diplopia (HP:0000651)2.88448415
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.82608844
36Cutaneous finger syndactyly (HP:0010554)2.82361531
37Anxiety (HP:0000739)2.80240125
38Renal hypoplasia (HP:0000089)2.75516648
39Abnormality of the lower motor neuron (HP:0002366)2.69601741
40Inability to walk (HP:0002540)2.68860571
41Delusions (HP:0000746)2.68627734
42Action tremor (HP:0002345)2.68223894
43Long clavicles (HP:0000890)2.68057495
44Hypsarrhythmia (HP:0002521)2.67873748
45Abnormal social behavior (HP:0012433)2.67828534
46Impaired social interactions (HP:0000735)2.67828534
47Truncal ataxia (HP:0002078)2.66901093
48Abnormality of salivation (HP:0100755)2.66349896
49Abnormality of the corticospinal tract (HP:0002492)2.65080982
50Dysmetria (HP:0001310)2.62422887
51Retinal dysplasia (HP:0007973)2.62002975
52Gaze-evoked nystagmus (HP:0000640)2.62000912
53Termporal pattern (HP:0011008)2.61951010
54Insidious onset (HP:0003587)2.61951010
55Cupped ear (HP:0000378)2.58521038
56Shawl scrotum (HP:0000049)2.57479164
57Hemiparesis (HP:0001269)2.57112350
58Neoplasm of the adrenal cortex (HP:0100641)2.56056584
59Depression (HP:0000716)2.55584595
60Abnormality of the astrocytes (HP:0100707)2.50985224
61Astrocytoma (HP:0009592)2.50985224
62Mutism (HP:0002300)2.50281060
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.50039916
64Hydroureter (HP:0000072)2.49080865
65Fetal akinesia sequence (HP:0001989)2.48050313
66Dysdiadochokinesis (HP:0002075)2.47236564
67Urinary bladder sphincter dysfunction (HP:0002839)2.45009475
68Patellar aplasia (HP:0006443)2.43810454
69Intestinal atresia (HP:0011100)2.40944540
70Impaired smooth pursuit (HP:0007772)2.40760686
71Stereotypic behavior (HP:0000733)2.40758884
72Chronic hepatic failure (HP:0100626)2.38686843
73Genetic anticipation (HP:0003743)2.37042612
74Facial hemangioma (HP:0000329)2.34681160
75Volvulus (HP:0002580)2.34652740
76Progressive inability to walk (HP:0002505)2.33996900
77Abnormality of the pubic bones (HP:0003172)2.33361141
78Small hand (HP:0200055)2.32825884
79Cystic liver disease (HP:0006706)2.31587728
80Lymphangioma (HP:0100764)2.30283713
81Inappropriate behavior (HP:0000719)2.29825846
82Birth length less than 3rd percentile (HP:0003561)2.29568010
83Ankle clonus (HP:0011448)2.28716697
84Heterotopia (HP:0002282)2.28594542
85Gait imbalance (HP:0002141)2.28211585
86Abnormal eating behavior (HP:0100738)2.27098711
87Obstructive sleep apnea (HP:0002870)2.26279736
88Thickened helices (HP:0000391)2.25623583
89Hypoplastic labia majora (HP:0000059)2.24566157
90Blue irides (HP:0000635)2.22248405
91Aplasia/Hypoplasia of the patella (HP:0006498)2.21492050
92Submucous cleft hard palate (HP:0000176)2.21333192
93Cutaneous syndactyly (HP:0012725)2.21025831
94Spastic gait (HP:0002064)2.18570977
95Aqueductal stenosis (HP:0002410)2.17894627
96Shoulder girdle muscle weakness (HP:0003547)2.17853612
97Ependymoma (HP:0002888)2.17797825
98Megalencephaly (HP:0001355)2.17286008
99Polyphagia (HP:0002591)2.13419727
100High anterior hairline (HP:0009890)2.10437714
101Urinary urgency (HP:0000012)2.09734396
102Heterochromia iridis (HP:0001100)2.09471168
103Exotropia (HP:0000577)2.08722049
104Labial hypoplasia (HP:0000066)2.07639393
105Abnormality of the labia (HP:0000058)2.06852424
106Optic nerve hypoplasia (HP:0000609)2.06342777
107Abnormality of the 4th metacarpal (HP:0010012)2.06066700
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05895831
109Degeneration of the lateral corticospinal tracts (HP:0002314)2.05895831
110Hypoplasia of the brainstem (HP:0002365)2.05715963
111Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05715963
112Gastrointestinal atresia (HP:0002589)2.05691175
113Impaired vibratory sensation (HP:0002495)2.04920149
114Widely spaced teeth (HP:0000687)2.04641875
115Fair hair (HP:0002286)2.02981877
116Abnormality of ocular smooth pursuit (HP:0000617)2.02852195
117Abnormality of the labia majora (HP:0012881)2.01706769
118Gastroesophageal reflux (HP:0002020)2.01567499
119Lower limb muscle weakness (HP:0007340)2.01292266
120Lissencephaly (HP:0001339)2.00803366
121Akinesia (HP:0002304)2.00314810
122Neoplasm of the oral cavity (HP:0100649)2.00308794
123Generalized myoclonic seizures (HP:0002123)2.00070774
124Tubulointerstitial nephritis (HP:0001970)1.98654480
125Intellectual disability, severe (HP:0010864)1.97250819
126Bradykinesia (HP:0002067)1.96658311
127Short chin (HP:0000331)1.95564634
128Palpebral edema (HP:0100540)1.95296110
129Abnormal hair whorl (HP:0010721)1.94978085
130Glioma (HP:0009733)1.94770915
131Abnormality of the metopic suture (HP:0005556)1.93804694
132Hypoplastic female external genitalia (HP:0012815)1.88694317
133Apathy (HP:0000741)1.88607302
134Incomplete penetrance (HP:0003829)1.88581318
135Back pain (HP:0003418)1.87737531
136Pachygyria (HP:0001302)1.87465791
137Medial flaring of the eyebrow (HP:0010747)1.86325210
138Generalized hypopigmentation of hair (HP:0011358)1.85867792
139Pheochromocytoma (HP:0002666)1.84189541
140Autism (HP:0000717)1.82583975
141Nephronophthisis (HP:0000090)1.82503212
142Sporadic (HP:0003745)1.82345019
143Papillary thyroid carcinoma (HP:0002895)1.81039609
144Hyperthyroidism (HP:0000836)1.80974548
145Scanning speech (HP:0002168)1.80064247
146Sleep apnea (HP:0010535)1.79198536
147Psychosis (HP:0000709)1.79163569
148Dysmetric saccades (HP:0000641)1.75640949
149Lower limb amyotrophy (HP:0007210)1.75370070
150Dyskinesia (HP:0100660)1.74989896
151Status epilepticus (HP:0002133)1.73835703
152Oligodactyly (HP:0012165)1.73260945
153Morphological abnormality of the middle ear (HP:0008609)1.73121075
154Hypoplasia of the corpus callosum (HP:0002079)1.72330202
155Abnormality of midbrain morphology (HP:0002418)1.71201594
156Molar tooth sign on MRI (HP:0002419)1.71201594
157Limb dystonia (HP:0002451)1.70539572
158Absent eyebrow (HP:0002223)1.68619209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.74158687
2MARK14.37500359
3CASK4.02560762
4FRK3.80386573
5NTRK33.79034064
6RIPK43.29567955
7MAP3K43.03721775
8MAP2K72.95223406
9PLK22.61016770
10MAP3K122.59789583
11MAP3K92.43900923
12MINK12.39421685
13DAPK22.34721043
14TRIM282.27083730
15DAPK12.08863663
16MAP2K41.84796040
17CDK191.73275874
18SIK21.69471758
19MAPK131.67373060
20BMPR21.65266650
21PNCK1.65236526
22KSR11.64482559
23GRK51.61115670
24FGFR21.53087395
25PTK2B1.48424390
26PRPF4B1.47582625
27NME11.46755468
28CAMK1G1.45849526
29NTRK21.38072642
30CDK51.36764455
31FGR1.35398053
32PAK61.33029525
33CAMK1D1.31372671
34MAP4K21.25235841
35PRKCG1.23072424
36PINK11.20530611
37CAMK2B1.19645592
38YES11.18312396
39CAMK2A1.18186289
40TNIK1.16127941
41MKNK21.00788027
42KSR20.99133318
43CCNB10.95373956
44LATS10.95174359
45FES0.94894629
46IRAK20.92579707
47CAMKK10.92176247
48OXSR10.92173748
49DYRK1A0.91679739
50GRK60.91159180
51TAOK10.86927360
52NUAK10.85856151
53CDK180.85646114
54DYRK20.84538359
55MAP3K60.83043050
56CDK140.81480572
57CDK150.80587631
58ARAF0.79380514
59NTRK10.78491854
60PLK40.78288922
61GRK70.75193564
62UHMK10.72788458
63PRKD30.70980119
64BCR0.70344445
65INSRR0.70138724
66CDK11A0.69369406
67SIK30.68200166
68PHKG20.68131089
69PHKG10.68131089
70CSNK1D0.67522865
71MAP3K130.67067979
72ERBB30.66597674
73AKT30.65132948
74MAPK80.64843113
75SGK4940.62779546
76SGK2230.62779546
77SGK10.61872292
78PRKCZ0.61610188
79CDK30.60350147
80RAF10.59757939
81SGK20.59195157
82LATS20.59106742
83STK110.58508799
84CSNK1G20.58368521
85PRKCE0.58332489
86EPHB20.56910577
87FER0.55570940
88EPHA30.55283116
89ROCK10.53676722
90CSNK1G30.51703302
91CAMK2D0.50714793
92IRAK10.50447690
93ZAK0.50386074
94CAMKK20.50384341
95MAPK120.47609461
96CSNK1A10.46163214
97ADRBK20.45677442
98CAMK10.45675416
99GSK3B0.45424655
100TYRO30.44925471
101ROCK20.44469597
102CSNK1A1L0.43909962
103PLK30.43552435
104ADRBK10.43506093
105PAK30.43412366
106BUB10.43183576
107EIF2AK30.40772864
108PRKDC0.40231774
109MARK20.39939546
110PKN10.39463994
111PDPK10.39088584
112ATM0.38769210
113PDK10.37938082
114STK380.37882081
115DAPK30.37857811
116WNK30.36698771
117FYN0.36214932
118MAP3K100.35415870
119RET0.35031109
120CSNK1G10.33840457
121PRKG10.32916092
122SYK0.32668410
123MAPK40.32328595
124MAP3K20.32145753
125MAPK90.31330251
126CDK10.30992199
127CSNK1E0.30536556
128RPS6KB10.30210984
129CAMK40.29698942
130MAP3K70.29435835
131PLK10.28904223
132MKNK10.28161935
133RPS6KA30.27420595
134CAMK2G0.27384935
135WNK40.26202073
136MAPK100.26189360
137RPS6KA20.26172991
138ILK0.25507804
139SGK30.25298141
140PRKCB0.24997264

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37688477
2Long-term potentiation_Homo sapiens_hsa047203.26196070
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00594542
4Synaptic vesicle cycle_Homo sapiens_hsa047212.90586431
5Circadian entrainment_Homo sapiens_hsa047132.88456479
6Amphetamine addiction_Homo sapiens_hsa050312.80466079
7Glutamatergic synapse_Homo sapiens_hsa047242.80280545
8Morphine addiction_Homo sapiens_hsa050322.55436288
9GABAergic synapse_Homo sapiens_hsa047272.44088524
10Dopaminergic synapse_Homo sapiens_hsa047282.41294773
11Olfactory transduction_Homo sapiens_hsa047402.37182947
12Salivary secretion_Homo sapiens_hsa049702.27133836
13Steroid biosynthesis_Homo sapiens_hsa001002.18566798
14Taste transduction_Homo sapiens_hsa047422.12305555
15Renin secretion_Homo sapiens_hsa049242.02911397
16Collecting duct acid secretion_Homo sapiens_hsa049661.99373500
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95835473
18Serotonergic synapse_Homo sapiens_hsa047261.92423942
19Long-term depression_Homo sapiens_hsa047301.91708773
20Gastric acid secretion_Homo sapiens_hsa049711.79778230
21Cholinergic synapse_Homo sapiens_hsa047251.78785408
22Insulin secretion_Homo sapiens_hsa049111.77684833
23Calcium signaling pathway_Homo sapiens_hsa040201.77398695
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74481418
25Axon guidance_Homo sapiens_hsa043601.72429900
26Oxytocin signaling pathway_Homo sapiens_hsa049211.68252833
27Non-homologous end-joining_Homo sapiens_hsa034501.62784021
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47126090
29Gap junction_Homo sapiens_hsa045401.39356941
30GnRH signaling pathway_Homo sapiens_hsa049121.36326276
31Cocaine addiction_Homo sapiens_hsa050301.29845364
32Protein export_Homo sapiens_hsa030601.29655743
33Fanconi anemia pathway_Homo sapiens_hsa034601.29483692
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26235832
35cAMP signaling pathway_Homo sapiens_hsa040241.23967073
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21966519
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21699625
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19415932
39Vibrio cholerae infection_Homo sapiens_hsa051101.18680819
40Propanoate metabolism_Homo sapiens_hsa006401.18392437
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16653109
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16010908
43Phototransduction_Homo sapiens_hsa047441.15856880
44Glioma_Homo sapiens_hsa052141.15185596
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14942147
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12802731
47Alzheimers disease_Homo sapiens_hsa050101.10854745
48Melanogenesis_Homo sapiens_hsa049161.10380270
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08097082
50Estrogen signaling pathway_Homo sapiens_hsa049151.07612623
51ErbB signaling pathway_Homo sapiens_hsa040121.04704474
52Caffeine metabolism_Homo sapiens_hsa002321.01001611
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00714034
54Homologous recombination_Homo sapiens_hsa034400.99057763
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98125776
56Oxidative phosphorylation_Homo sapiens_hsa001900.92733153
57Ether lipid metabolism_Homo sapiens_hsa005650.90763584
58Type II diabetes mellitus_Homo sapiens_hsa049300.89882988
59Basal transcription factors_Homo sapiens_hsa030220.89592878
60Oocyte meiosis_Homo sapiens_hsa041140.88645851
61Cardiac muscle contraction_Homo sapiens_hsa042600.88011015
62VEGF signaling pathway_Homo sapiens_hsa043700.84530429
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83916306
64African trypanosomiasis_Homo sapiens_hsa051430.80824320
65Choline metabolism in cancer_Homo sapiens_hsa052310.77165479
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75892121
67Pancreatic secretion_Homo sapiens_hsa049720.72189531
68Hedgehog signaling pathway_Homo sapiens_hsa043400.72011654
69Butanoate metabolism_Homo sapiens_hsa006500.67122066
70MAPK signaling pathway_Homo sapiens_hsa040100.64841333
71Glucagon signaling pathway_Homo sapiens_hsa049220.64509526
72Ras signaling pathway_Homo sapiens_hsa040140.64396744
73Linoleic acid metabolism_Homo sapiens_hsa005910.64114487
74Melanoma_Homo sapiens_hsa052180.57534101
75Wnt signaling pathway_Homo sapiens_hsa043100.54320722
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.54149015
77Thyroid hormone synthesis_Homo sapiens_hsa049180.53613851
78Rap1 signaling pathway_Homo sapiens_hsa040150.52996207
79Parkinsons disease_Homo sapiens_hsa050120.51999958
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.51737601
81Ovarian steroidogenesis_Homo sapiens_hsa049130.51543773
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51174270
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.51001958
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49592565
85Tight junction_Homo sapiens_hsa045300.49471808
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49056158
87Huntingtons disease_Homo sapiens_hsa050160.48534621
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47862483
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47446240
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46943268
91Alcoholism_Homo sapiens_hsa050340.45738768
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44999394
93Colorectal cancer_Homo sapiens_hsa052100.44660873
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44571278
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44370866
96Fatty acid metabolism_Homo sapiens_hsa012120.44295628
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43091656
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42436925
99FoxO signaling pathway_Homo sapiens_hsa040680.42205931
100Dilated cardiomyopathy_Homo sapiens_hsa054140.42185947
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41468332
102ABC transporters_Homo sapiens_hsa020100.41175089
103Tryptophan metabolism_Homo sapiens_hsa003800.39677350
104AMPK signaling pathway_Homo sapiens_hsa041520.39223807
105Rheumatoid arthritis_Homo sapiens_hsa053230.37983593
106Dorso-ventral axis formation_Homo sapiens_hsa043200.37769175
107Lysine degradation_Homo sapiens_hsa003100.37680112
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37460697
109MicroRNAs in cancer_Homo sapiens_hsa052060.36524878
110Basal cell carcinoma_Homo sapiens_hsa052170.36192556
111Endometrial cancer_Homo sapiens_hsa052130.35829381
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35650309
113Inositol phosphate metabolism_Homo sapiens_hsa005620.35000276
114Fatty acid biosynthesis_Homo sapiens_hsa000610.34705024
115Renal cell carcinoma_Homo sapiens_hsa052110.33770805
116Non-small cell lung cancer_Homo sapiens_hsa052230.32111547
117Phagosome_Homo sapiens_hsa041450.31322136
118mTOR signaling pathway_Homo sapiens_hsa041500.30958843
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30902580
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27492715
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25060872
122Prion diseases_Homo sapiens_hsa050200.24457917
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24442402
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24112734
125Salmonella infection_Homo sapiens_hsa051320.23685147
126Endocytosis_Homo sapiens_hsa041440.23467657
127Circadian rhythm_Homo sapiens_hsa047100.23135490
128Insulin signaling pathway_Homo sapiens_hsa049100.23129281
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23027763

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