NEURL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.83256628
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.62858704
3glutamate secretion (GO:0014047)5.90672311
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85507428
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.74547946
6synaptic vesicle exocytosis (GO:0016079)5.36331366
7regulation of synaptic vesicle exocytosis (GO:2000300)5.23200981
8neuronal action potential propagation (GO:0019227)5.12686437
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.00455367
10neurotransmitter secretion (GO:0007269)4.79106817
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.68054493
12regulation of synaptic vesicle transport (GO:1902803)4.66044814
13cellular potassium ion homeostasis (GO:0030007)4.56234230
14sarcoplasmic reticulum calcium ion transport (GO:0070296)4.55100911
15sodium ion export (GO:0071436)4.26775362
16proline transport (GO:0015824)4.08856221
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.04799865
18locomotory exploration behavior (GO:0035641)3.96108825
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.90161517
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89680054
21membrane depolarization during action potential (GO:0086010)3.89498388
22dendritic spine morphogenesis (GO:0060997)3.86603587
23neuromuscular synaptic transmission (GO:0007274)3.85787871
24regulation of cell communication by electrical coupling (GO:0010649)3.85459154
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84018514
26* regulation of neuronal synaptic plasticity (GO:0048168)3.83855717
27neurotransmitter transport (GO:0006836)3.83325962
28actin-myosin filament sliding (GO:0033275)3.80452134
29muscle filament sliding (GO:0030049)3.80452134
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78788235
31vocalization behavior (GO:0071625)3.71495153
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.69508122
33skeletal muscle contraction (GO:0003009)3.68920844
34regulation of skeletal muscle contraction (GO:0014819)3.59958425
35cerebellar granule cell differentiation (GO:0021707)3.59879799
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59399251
37* positive regulation of synapse maturation (GO:0090129)3.58666327
38regulation of neurotransmitter levels (GO:0001505)3.58303251
39exploration behavior (GO:0035640)3.58283737
40potassium ion import (GO:0010107)3.57258970
41regulation of synapse structural plasticity (GO:0051823)3.57258701
42regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.55264997
43regulation of glutamate receptor signaling pathway (GO:1900449)3.50516132
44synaptic transmission, glutamatergic (GO:0035249)3.47662558
45regulation of relaxation of muscle (GO:1901077)3.45682809
46* regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45072000
47regulation of voltage-gated calcium channel activity (GO:1901385)3.44228635
48creatine metabolic process (GO:0006600)3.43308236
49positive regulation of membrane potential (GO:0045838)3.43181596
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.41599303
51postsynaptic membrane organization (GO:0001941)3.41104134
52regulation of neurotransmitter secretion (GO:0046928)3.38564935
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.37238241
54potassium ion homeostasis (GO:0055075)3.35201995
55positive regulation of neurotransmitter transport (GO:0051590)3.30202862
56striated muscle contraction (GO:0006941)3.28252824
57regulation of ARF protein signal transduction (GO:0032012)3.27801711
58protein localization to synapse (GO:0035418)3.23306819
59regulation of neurotransmitter transport (GO:0051588)3.20954800
60neuron-neuron synaptic transmission (GO:0007270)3.20860733
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16302920
62L-amino acid import (GO:0043092)3.15383996
63glutamate receptor signaling pathway (GO:0007215)3.14912709
64positive regulation of neurotransmitter secretion (GO:0001956)3.11934841
65neurotransmitter-gated ion channel clustering (GO:0072578)3.07565914
66membrane depolarization (GO:0051899)3.07029077
67neuronal ion channel clustering (GO:0045161)3.06914948
68regulation of vesicle fusion (GO:0031338)3.05728253
69regulation of calcium ion transmembrane transport (GO:1903169)3.05123238
70regulation of calcium ion transmembrane transporter activity (GO:1901019)3.05123238
71regulation of sodium ion transmembrane transporter activity (GO:2000649)3.04706429
72cell communication by electrical coupling (GO:0010644)3.04300718
73detection of calcium ion (GO:0005513)3.03478930
74regulation of postsynaptic membrane potential (GO:0060078)3.02509851
75* regulation of synaptic plasticity (GO:0048167)3.02508029
76actin-mediated cell contraction (GO:0070252)2.99540284
77gamma-aminobutyric acid transport (GO:0015812)2.98952019
78dendritic spine organization (GO:0097061)2.96592789
79chemosensory behavior (GO:0007635)2.94951357
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93523234
81regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93360821
82cerebellar Purkinje cell differentiation (GO:0021702)2.91499213
83calcium ion-dependent exocytosis (GO:0017156)2.91204213
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90156018
85auditory behavior (GO:0031223)2.89254297
86regulation of dendritic spine morphogenesis (GO:0061001)2.87508276
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84639692
88negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.84587230
89negative regulation of calcium ion transmembrane transport (GO:1903170)2.84587230
90* positive regulation of dendritic spine development (GO:0060999)2.83045808
91regulation of membrane repolarization (GO:0060306)2.83019926
92cellular sodium ion homeostasis (GO:0006883)2.82903020
93synaptic vesicle endocytosis (GO:0048488)2.82678275
94synaptic transmission (GO:0007268)2.82259042
95* regulation of synapse maturation (GO:0090128)2.82059630
96regulation of sodium ion transmembrane transport (GO:1902305)2.79189923
97signal release (GO:0023061)2.78877288
98potassium ion transmembrane transport (GO:0071805)2.77240660
99cellular potassium ion transport (GO:0071804)2.77240660
100neuromuscular process controlling balance (GO:0050885)2.76533462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97853182
2DROSHA_22980978_ChIP-Seq_HELA_Human3.16445473
3REST_21632747_ChIP-Seq_MESCs_Mouse3.06650773
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.99070662
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.93932741
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68723029
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.68649547
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60064083
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45311694
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43334140
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.40805720
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39559094
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35833692
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30102895
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26435957
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20647572
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.18932801
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08491535
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.08227364
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04146556
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02221392
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02221392
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98508242
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97724557
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84158361
26RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.72876873
27GBX2_23144817_ChIP-Seq_PC3_Human1.71033884
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69047090
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66448072
30CTCF_27219007_Chip-Seq_Bcells_Human1.66253861
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61398253
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54077399
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53147246
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52928152
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.43997144
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42119157
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.41499147
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30110218
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29533582
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29274027
41TET1_21490601_ChIP-Seq_MESCs_Mouse1.24251622
42OCT4_19829295_ChIP-Seq_ESCs_Human1.20312766
43KDM2B_26808549_Chip-Seq_K562_Human1.20039358
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19745783
45LXR_22292898_ChIP-Seq_THP-1_Human1.19396908
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19370063
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17911001
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15505153
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15255588
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14554910
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.12741709
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.12017434
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08683634
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07951780
55SMC4_20622854_ChIP-Seq_HELA_Human1.05889747
56P68_20966046_ChIP-Seq_HELA_Human1.03003288
57AR_21572438_ChIP-Seq_LNCaP_Human1.00538429
58AR_19668381_ChIP-Seq_PC3_Human1.00374885
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98743009
60SOX2_21211035_ChIP-Seq_LN229_Gbm0.98323098
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97309246
62KLF4_19829295_ChIP-Seq_ESCs_Human0.93840695
63SA1_27219007_Chip-Seq_Bcells_Human0.92859630
64OCT4_20526341_ChIP-Seq_ESCs_Human0.92698749
65DPY_21335234_ChIP-Seq_ESCs_Mouse0.92397788
66CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89891264
67SMAD4_21741376_ChIP-Seq_ESCs_Human0.88167697
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87941249
69P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87840570
70ESR2_21235772_ChIP-Seq_MCF-7_Human0.87295574
71CREB1_26743006_Chip-Seq_LNCaP_Human0.86298212
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85949614
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85436221
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84055965
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84048418
76RNF2_27304074_Chip-Seq_NSC_Mouse0.83794015
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82804808
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81699243
79SMAD4_21799915_ChIP-Seq_A2780_Human0.81243639
80ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79244027
81RING1B_27294783_Chip-Seq_NPCs_Mouse0.79098819
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77635552
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77054407
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77033233
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76250105
86MYC_19829295_ChIP-Seq_ESCs_Human0.74900424
87TET1_21451524_ChIP-Seq_MESCs_Mouse0.74653660
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74268055
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73961394
90TCF4_23295773_ChIP-Seq_U87_Human0.73846084
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73259138
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73071894
93HTT_18923047_ChIP-ChIP_STHdh_Human0.73003916
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72986378
95MYC_27129775_Chip-Seq_CORNEA_Mouse0.72513499
96NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72188369
97IGF1R_20145208_ChIP-Seq_DFB_Human0.72119219
98E2F1_20622854_ChIP-Seq_HELA_Human0.71333545
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70555967
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69102634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18415720
2MP0004270_analgesia4.48306069
3MP0003880_abnormal_central_pattern4.07870979
4MP0005423_abnormal_somatic_nervous3.38447629
5MP0003635_abnormal_synaptic_transmissio3.29036906
6MP0004145_abnormal_muscle_electrophysio3.22735263
7MP0002064_seizures2.99322022
8MP0009745_abnormal_behavioral_response2.85775068
9MP0003646_muscle_fatigue2.68213562
10MP0003879_abnormal_hair_cell2.67416634
11MP0002734_abnormal_mechanical_nocicepti2.62754438
12MP0002272_abnormal_nervous_system2.61848433
13MP0002063_abnormal_learning/memory/cond2.58299818
14MP0009046_muscle_twitch2.58057901
15MP0001486_abnormal_startle_reflex2.38696602
16MP0000751_myopathy2.30942048
17MP0001501_abnormal_sleep_pattern2.29188411
18MP0002572_abnormal_emotion/affect_behav2.22875447
19MP0003787_abnormal_imprinting2.21131589
20MP0001968_abnormal_touch/_nociception2.16682520
21MP0002822_catalepsy2.13237014
22MP0000749_muscle_degeneration2.11364136
23MP0009780_abnormal_chondrocyte_physiolo2.09256582
24MP0008569_lethality_at_weaning1.94650537
25MP0004130_abnormal_muscle_cell1.74803087
26MP0001970_abnormal_pain_threshold1.74280707
27MP0002733_abnormal_thermal_nociception1.72168294
28MP0004147_increased_porphyrin_level1.66355323
29MP0002735_abnormal_chemical_nociception1.65992253
30MP0004036_abnormal_muscle_relaxation1.65578922
31MP0006276_abnormal_autonomic_nervous1.57663784
32MP0003329_amyloid_beta_deposits1.52822814
33MP0000747_muscle_weakness1.52048415
34MP0002067_abnormal_sensory_capabilities1.51883103
35MP0002106_abnormal_muscle_physiology1.50609966
36MP0001502_abnormal_circadian_rhythm1.46811651
37MP0002638_abnormal_pupillary_reflex1.43584331
38MP0001440_abnormal_grooming_behavior1.41167579
39MP0002557_abnormal_social/conspecific_i1.38361161
40MP0003122_maternal_imprinting1.37630491
41MP0005646_abnormal_pituitary_gland1.36575134
42MP0005645_abnormal_hypothalamus_physiol1.36268146
43MP0003123_paternal_imprinting1.36160787
44MP0004924_abnormal_behavior1.35517099
45MP0005386_behavior/neurological_phenoty1.35517099
46MP0002736_abnormal_nociception_after1.33488196
47MP0002066_abnormal_motor_capabilities/c1.30645781
48MP0000759_abnormal_skeletal_muscle1.28332668
49MP0003633_abnormal_nervous_system1.26146808
50MP0004811_abnormal_neuron_physiology1.26117463
51MP0002909_abnormal_adrenal_gland1.25325657
52MP0002837_dystrophic_cardiac_calcinosis1.21255872
53MP0005369_muscle_phenotype1.19646018
54MP0001905_abnormal_dopamine_level1.17652170
55MP0006036_abnormal_mitochondrial_physio1.15882832
56MP0008877_abnormal_DNA_methylation1.14432783
57MP0004087_abnormal_muscle_fiber1.12878093
58MP0004885_abnormal_endolymph1.12572053
59MP0000013_abnormal_adipose_tissue1.12550817
60MP0005620_abnormal_muscle_contractility1.11970329
61MP0005535_abnormal_body_temperature1.10262520
62MP0002229_neurodegeneration1.08903231
63MP0002332_abnormal_exercise_endurance1.06252371
64MP0002882_abnormal_neuron_morphology1.05515672
65MP0002876_abnormal_thyroid_physiology1.04669219
66MP0001984_abnormal_olfaction1.02694777
67MP0003631_nervous_system_phenotype1.00279109
68MP0001986_abnormal_taste_sensitivity1.00022528
69MP0003690_abnormal_glial_cell0.97683420
70MP0002269_muscular_atrophy0.97543574
71MP0005551_abnormal_eye_electrophysiolog0.96175259
72MP0008872_abnormal_physiological_respon0.95489887
73MP0002184_abnormal_innervation0.94534834
74MP0000955_abnormal_spinal_cord0.92529263
75MP0004484_altered_response_of0.92445223
76MP0001485_abnormal_pinna_reflex0.92141265
77MP0004215_abnormal_myocardial_fiber0.91407183
78MP0000750_abnormal_muscle_regeneration0.85851695
79MP0004510_myositis0.85472219
80MP0000920_abnormal_myelination0.85169370
81MP0001963_abnormal_hearing_physiology0.85089177
82MP0004043_abnormal_pH_regulation0.84553686
83MP0001765_abnormal_ion_homeostasis0.83059555
84MP0002078_abnormal_glucose_homeostasis0.82987780
85MP0004142_abnormal_muscle_tone0.82407023
86MP0003137_abnormal_impulse_conducting0.81384502
87MP0005451_abnormal_body_composition0.80957851
88MP0004085_abnormal_heartbeat0.80672127
89MP0008874_decreased_physiological_sensi0.79181629
90MP0003283_abnormal_digestive_organ0.79124129
91MP0003045_fibrosis0.76707256
92MP0002693_abnormal_pancreas_physiology0.75365633
93MP0000778_abnormal_nervous_system0.73418611
94MP0002069_abnormal_eating/drinking_beha0.71500082
95MP0003075_altered_response_to0.71185440
96MP0003172_abnormal_lysosome_physiology0.69282433
97MP0004742_abnormal_vestibular_system0.69171710
98MP0003183_abnormal_peptide_metabolism0.68123313
99MP0005330_cardiomyopathy0.67609131
100MP0002971_abnormal_brown_adipose0.67216261

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.45766442
2Nemaline bodies (HP:0003798)6.42991581
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.18832020
4Exercise-induced myalgia (HP:0003738)5.40033944
5Myokymia (HP:0002411)5.02431331
6Focal motor seizures (HP:0011153)4.92904243
7Type 1 muscle fiber predominance (HP:0003803)4.35846200
8Exercise-induced muscle cramps (HP:0003710)4.27239138
9Focal seizures (HP:0007359)4.03442802
10Febrile seizures (HP:0002373)4.00060023
11Muscle hypertrophy of the lower extremities (HP:0008968)3.95920361
12Distal arthrogryposis (HP:0005684)3.91991086
13Ankle clonus (HP:0011448)3.88311638
14Myopathic facies (HP:0002058)3.78645132
15Fetal akinesia sequence (HP:0001989)3.63896315
16Calf muscle hypertrophy (HP:0008981)3.54536842
17Epileptic encephalopathy (HP:0200134)3.49102274
18EMG: myopathic abnormalities (HP:0003458)3.43535675
19Round ear (HP:0100830)3.34802677
20Visual hallucinations (HP:0002367)3.32755258
21Abnormality of binocular vision (HP:0011514)3.29994303
22Diplopia (HP:0000651)3.29994303
23Atonic seizures (HP:0010819)3.26383638
24Action tremor (HP:0002345)3.21970857
25Generalized tonic-clonic seizures (HP:0002069)3.16879572
26Muscle fiber splitting (HP:0003555)3.00277718
27Hyporeflexia of lower limbs (HP:0002600)2.98506260
28Rhabdomyolysis (HP:0003201)2.96896043
29Myoglobinuria (HP:0002913)2.96857603
30Difficulty running (HP:0009046)2.96419252
31Bundle branch block (HP:0011710)2.93350598
32Limb dystonia (HP:0002451)2.87830530
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.84492619
34Absence seizures (HP:0002121)2.83610609
35Progressive cerebellar ataxia (HP:0002073)2.82970680
36Supranuclear gaze palsy (HP:0000605)2.80062162
37Akinesia (HP:0002304)2.79924377
38Muscle stiffness (HP:0003552)2.77680995
39Rimmed vacuoles (HP:0003805)2.71972442
40Myotonia (HP:0002486)2.71265399
41Frequent falls (HP:0002359)2.69965216
42Dialeptic seizures (HP:0011146)2.63812164
43Postural instability (HP:0002172)2.61153021
44Spastic gait (HP:0002064)2.60894726
45Epileptiform EEG discharges (HP:0011182)2.60695338
46Poor eye contact (HP:0000817)2.60663671
47Abnormality of the left ventricular outflow tract (HP:0011103)2.60558774
48Subaortic stenosis (HP:0001682)2.60558774
49Sudden death (HP:0001699)2.57215019
50Urinary bladder sphincter dysfunction (HP:0002839)2.54817676
51Abnormality of the calf musculature (HP:0001430)2.53709980
52Abnormal eating behavior (HP:0100738)2.48702667
53Ulnar deviation of the wrist (HP:0003049)2.48073263
54Ventricular fibrillation (HP:0001663)2.45178133
55EEG with generalized epileptiform discharges (HP:0011198)2.42720332
56EMG: neuropathic changes (HP:0003445)2.41190676
57Obstructive sleep apnea (HP:0002870)2.34795324
58Papilledema (HP:0001085)2.34583347
59Hypsarrhythmia (HP:0002521)2.31131126
60Tetraplegia (HP:0002445)2.29906736
61Insulin-resistant diabetes mellitus (HP:0000831)2.29439404
62Impaired vibration sensation in the lower limbs (HP:0002166)2.26921998
63Neck muscle weakness (HP:0000467)2.26040231
64Hemiparesis (HP:0001269)2.25507413
65Anxiety (HP:0000739)2.25294186
66Torticollis (HP:0000473)2.25023681
67Abnormality of skeletal muscle fiber size (HP:0012084)2.23944299
68Heart block (HP:0012722)2.23282876
69Depression (HP:0000716)2.22243116
70Cerebral hypomyelination (HP:0006808)2.18599543
71Hyperinsulinemic hypoglycemia (HP:0000825)2.16979689
72Broad-based gait (HP:0002136)2.16301739
73Clonus (HP:0002169)2.12521964
74Asymmetric septal hypertrophy (HP:0001670)2.10579758
75Hyperkalemia (HP:0002153)2.10343868
76Lower limb muscle weakness (HP:0007340)2.09620482
77Focal dystonia (HP:0004373)2.08651716
78Abnormal EKG (HP:0003115)2.07806122
79Urinary urgency (HP:0000012)2.07326936
80Prolonged QT interval (HP:0001657)2.06919743
81Rigidity (HP:0002063)2.06595338
82Bradykinesia (HP:0002067)2.06149233
83Status epilepticus (HP:0002133)2.03401375
84Abnormal social behavior (HP:0012433)2.02251097
85Impaired social interactions (HP:0000735)2.02251097
86Truncal ataxia (HP:0002078)2.00950441
87Distal lower limb muscle weakness (HP:0009053)2.00393688
88Mutism (HP:0002300)1.99342092
89Intention tremor (HP:0002080)1.99130178
90Annular pancreas (HP:0001734)1.96472511
91Sleep apnea (HP:0010535)1.95975970
92Hemiplegia (HP:0002301)1.95870500
93Dysmetria (HP:0001310)1.95866320
94Abnormal atrioventricular conduction (HP:0005150)1.95720182
95Calcaneovalgus deformity (HP:0001848)1.94913363
96Malignant hyperthermia (HP:0002047)1.93935277
97Lower limb amyotrophy (HP:0007210)1.93817423
98Delusions (HP:0000746)1.90502812
99Nonprogressive disorder (HP:0003680)1.88623047
100Rapidly progressive (HP:0003678)1.87737869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG24.49989582
2PHKG14.49989582
3OBSCN4.42168818
4DAPK23.89387851
5EPHA43.83730993
6MARK13.54253189
7NTRK33.24003329
8PAK62.66336118
9PINK12.26076568
10UHMK12.02290156
11MAP3K91.92806012
12PRKD31.84541206
13NTRK21.71601659
14CAMKK11.65599987
15MAPK121.59057307
16TTN1.58325572
17MAPK131.56831040
18CAMK11.44072939
19CASK1.43595677
20MINK11.39779866
21RIPK41.29963146
22DAPK11.22494989
23MAP2K61.22209431
24CDK191.22044937
25CDK51.21684893
26MAP2K41.17366470
27SGK2231.15360635
28SGK4941.15360635
29ARAF1.12800401
30STK111.07828826
31SIK21.06935743
32PRKCH1.05893305
33PLK21.04621372
34GRK51.01245858
35PAK31.00288274
36CAMK2B1.00008252
37MAP3K70.99879692
38RIPK10.99171422
39MARK20.98711635
40OXSR10.97333341
41CAMK2G0.96037417
42CAMK2A0.94044593
43SGK20.92924544
44CAMK40.90145402
45PRKCG0.89229340
46TNK20.88297076
47LIMK10.87796288
48PIK3CG0.87239034
49KSR20.85535421
50FRK0.84609506
51LATS20.83432758
52MAP3K110.83260367
53PDK10.82443793
54INSRR0.81958076
55SGK30.81877565
56STK380.81250182
57MAP3K40.80917621
58SGK10.80895597
59PDPK10.80521762
60CCNB10.77928143
61MAP3K10.75834131
62PKN10.75246049
63PRPF4B0.73227492
64CAMKK20.70413838
65MAP3K130.69176777
66MUSK0.68636076
67CAMK2D0.67877009
68NEK60.64505922
69DYRK1A0.63702658
70NME10.61753995
71PRKAA10.61699249
72TESK10.57635651
73RPS6KA30.56064605
74MAPK100.55575467
75CDK150.54320522
76PRKG10.50910974
77CDK180.50749784
78CDK11A0.50341829
79PRKG20.50014605
80ALK0.49157494
81MAP2K70.48157653
82CDK140.47533582
83PRKACA0.44403409
84MAP2K10.41913194
85PRKCZ0.39224837
86DAPK30.38623094
87PRKCA0.38586362
88NTRK10.38067162
89BRAF0.38018782
90BMPR20.35418783
91MAP3K20.35370800
92WNK40.35290994
93PRKAA20.34751926
94ROCK10.33294327
95TYRO30.33029756
96MAPK40.32563515
97RPS6KB10.31475430
98AKT20.29435641
99FGFR20.28660427
100MAPK80.27836070

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.45851461
2Nicotine addiction_Homo sapiens_hsa050333.33741745
3Insulin secretion_Homo sapiens_hsa049112.84807992
4Circadian entrainment_Homo sapiens_hsa047132.58296784
5Amphetamine addiction_Homo sapiens_hsa050312.54366475
6Long-term potentiation_Homo sapiens_hsa047202.52749146
7GABAergic synapse_Homo sapiens_hsa047272.35245657
8Morphine addiction_Homo sapiens_hsa050322.20951529
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19424979
10Glutamatergic synapse_Homo sapiens_hsa047242.16172915
11Cardiac muscle contraction_Homo sapiens_hsa042602.15362213
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13406541
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.11313022
14Gastric acid secretion_Homo sapiens_hsa049712.04349091
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01424463
16Aldosterone synthesis and secretion_Homo sapiens_hsa049252.00919386
17Dopaminergic synapse_Homo sapiens_hsa047281.95943488
18Oxytocin signaling pathway_Homo sapiens_hsa049211.91702741
19Calcium signaling pathway_Homo sapiens_hsa040201.85718585
20Cholinergic synapse_Homo sapiens_hsa047251.69783285
21Salivary secretion_Homo sapiens_hsa049701.69138071
22Renin secretion_Homo sapiens_hsa049241.63816135
23Cocaine addiction_Homo sapiens_hsa050301.62514051
24Circadian rhythm_Homo sapiens_hsa047101.53966361
25Glucagon signaling pathway_Homo sapiens_hsa049221.40459025
26cAMP signaling pathway_Homo sapiens_hsa040241.30183828
27GnRH signaling pathway_Homo sapiens_hsa049121.29673387
28Dilated cardiomyopathy_Homo sapiens_hsa054141.28861163
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28437569
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27353645
31Long-term depression_Homo sapiens_hsa047301.27081363
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26878128
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26750057
34Phototransduction_Homo sapiens_hsa047441.19574274
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.17668443
36Olfactory transduction_Homo sapiens_hsa047401.17453805
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17253312
38Taste transduction_Homo sapiens_hsa047421.14775031
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12428522
40Type II diabetes mellitus_Homo sapiens_hsa049301.12406625
41Serotonergic synapse_Homo sapiens_hsa047261.11532998
42Pancreatic secretion_Homo sapiens_hsa049721.10945878
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10735483
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09986941
45Arginine and proline metabolism_Homo sapiens_hsa003301.08311445
46Arginine biosynthesis_Homo sapiens_hsa002201.05498852
47Collecting duct acid secretion_Homo sapiens_hsa049661.04858464
48Vitamin B6 metabolism_Homo sapiens_hsa007500.99050055
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97988830
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.97917628
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97005600
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92239921
53Alzheimers disease_Homo sapiens_hsa050100.81048337
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80883880
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79728134
56Butanoate metabolism_Homo sapiens_hsa006500.79321941
57Bile secretion_Homo sapiens_hsa049760.78875376
58Insulin signaling pathway_Homo sapiens_hsa049100.78201292
59Melanogenesis_Homo sapiens_hsa049160.74550812
60Estrogen signaling pathway_Homo sapiens_hsa049150.73946940
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73554563
62Inositol phosphate metabolism_Homo sapiens_hsa005620.72374281
63Regulation of autophagy_Homo sapiens_hsa041400.67919755
64Oocyte meiosis_Homo sapiens_hsa041140.63798711
65Thyroid hormone synthesis_Homo sapiens_hsa049180.63214662
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61898183
67Nitrogen metabolism_Homo sapiens_hsa009100.61450335
68Glioma_Homo sapiens_hsa052140.60741562
69Gap junction_Homo sapiens_hsa045400.60612124
70MAPK signaling pathway_Homo sapiens_hsa040100.59372214
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57665643
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56726216
73AMPK signaling pathway_Homo sapiens_hsa041520.55077741
74Ovarian steroidogenesis_Homo sapiens_hsa049130.53850877
75Mineral absorption_Homo sapiens_hsa049780.53555321
76Oxidative phosphorylation_Homo sapiens_hsa001900.53403292
77Dorso-ventral axis formation_Homo sapiens_hsa043200.49194318
78VEGF signaling pathway_Homo sapiens_hsa043700.49110974
79Vibrio cholerae infection_Homo sapiens_hsa051100.49015262
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44887399
81ErbB signaling pathway_Homo sapiens_hsa040120.44785214
82Parkinsons disease_Homo sapiens_hsa050120.44485927
83beta-Alanine metabolism_Homo sapiens_hsa004100.42971978
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42810723
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.41986288
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.40379760
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.40104763
88Histidine metabolism_Homo sapiens_hsa003400.39432132
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38981314
90Axon guidance_Homo sapiens_hsa043600.36465614
91Insulin resistance_Homo sapiens_hsa049310.35969420
92Ras signaling pathway_Homo sapiens_hsa040140.35242325
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34730039
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.34233791
95Folate biosynthesis_Homo sapiens_hsa007900.32312773
96Fructose and mannose metabolism_Homo sapiens_hsa000510.32061900
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29721799
98mTOR signaling pathway_Homo sapiens_hsa041500.29432583
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29046295
100Tight junction_Homo sapiens_hsa045300.28309221

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