NETO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.63192130
2layer formation in cerebral cortex (GO:0021819)5.62884451
3locomotory exploration behavior (GO:0035641)5.48734805
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47341430
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40671912
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39102316
7neuron cell-cell adhesion (GO:0007158)5.25490037
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15492143
9synaptic vesicle maturation (GO:0016188)5.13096239
10synaptic vesicle exocytosis (GO:0016079)4.99365443
11protein localization to synapse (GO:0035418)4.97912115
12regulation of synapse structural plasticity (GO:0051823)4.83052818
13exploration behavior (GO:0035640)4.69531253
14* regulation of glutamate receptor signaling pathway (GO:1900449)4.65453436
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.64905841
16dendritic spine morphogenesis (GO:0060997)4.60162247
17regulation of synaptic vesicle exocytosis (GO:2000300)4.57505154
18glutamate secretion (GO:0014047)4.54027216
19neuron recognition (GO:0008038)4.36739008
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36423411
21positive regulation of synapse maturation (GO:0090129)4.31348760
22glutamate receptor signaling pathway (GO:0007215)4.26413907
23axonal fasciculation (GO:0007413)4.17965689
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.16291207
25pyrimidine nucleobase catabolic process (GO:0006208)4.15172726
26synaptic transmission, glutamatergic (GO:0035249)4.14780046
27neurotransmitter secretion (GO:0007269)4.08453622
28dendrite morphogenesis (GO:0048813)4.06944020
29neuron-neuron synaptic transmission (GO:0007270)4.03819187
30neurotransmitter-gated ion channel clustering (GO:0072578)4.03691645
31regulation of neuronal synaptic plasticity (GO:0048168)3.99689472
32regulation of synaptic vesicle transport (GO:1902803)3.93574111
33prepulse inhibition (GO:0060134)3.93306307
34regulation of dendritic spine morphogenesis (GO:0061001)3.92409100
35cell migration in hindbrain (GO:0021535)3.90721614
36neuronal action potential propagation (GO:0019227)3.87170022
37gamma-aminobutyric acid transport (GO:0015812)3.86650422
38auditory behavior (GO:0031223)3.86476325
39central nervous system projection neuron axonogenesis (GO:0021952)3.84891387
40postsynaptic membrane organization (GO:0001941)3.82813800
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80316978
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78488172
43proline transport (GO:0015824)3.72970264
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67879783
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.66050956
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64584430
47transmission of nerve impulse (GO:0019226)3.61082709
48positive regulation of membrane potential (GO:0045838)3.60394589
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.59448272
50long-term memory (GO:0007616)3.57411807
51synapse assembly (GO:0007416)3.51937303
52activation of protein kinase A activity (GO:0034199)3.51861340
53cerebellar granule cell differentiation (GO:0021707)3.48792301
54nucleobase catabolic process (GO:0046113)3.48414057
55regulation of postsynaptic membrane potential (GO:0060078)3.48008134
56neuromuscular process controlling balance (GO:0050885)3.46448606
57presynaptic membrane assembly (GO:0097105)3.44364309
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.43073487
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38947701
60response to auditory stimulus (GO:0010996)3.37113267
61mechanosensory behavior (GO:0007638)3.34922058
62regulation of centriole replication (GO:0046599)3.34523399
63clathrin coat assembly (GO:0048268)3.30972524
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29792877
65positive regulation of cell cycle G2/M phase transition (GO:1902751)3.27858133
66positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.27858133
67regulation of synaptic plasticity (GO:0048167)3.26976933
68regulation of dendritic spine development (GO:0060998)3.26272523
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26094199
70establishment of nucleus localization (GO:0040023)3.24621003
71regulation of synapse maturation (GO:0090128)3.23738231
72presynaptic membrane organization (GO:0097090)3.22050566
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.21388765
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21228815
75adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.20763184
76innervation (GO:0060384)3.19703909
77behavioral fear response (GO:0001662)3.18998926
78behavioral defense response (GO:0002209)3.18998926
79dopamine receptor signaling pathway (GO:0007212)3.18832773
80neurotransmitter transport (GO:0006836)3.17659276
81positive regulation of dendritic spine development (GO:0060999)3.15217661
82organelle transport along microtubule (GO:0072384)3.14755997
83negative regulation of microtubule polymerization (GO:0031115)3.14429186
84DNA replication checkpoint (GO:0000076)3.14332905
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13659105
86long-term synaptic potentiation (GO:0060291)3.12821529
87synapse organization (GO:0050808)3.10399666
88synaptic vesicle endocytosis (GO:0048488)3.10204467
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09951014
90dendritic spine organization (GO:0097061)3.08879027
91regulation of neurotransmitter secretion (GO:0046928)3.08095127
92learning (GO:0007612)3.07960885
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07721500
94sister chromatid segregation (GO:0000819)3.06921507
95intraspecies interaction between organisms (GO:0051703)3.06849310
96social behavior (GO:0035176)3.06849310
97vesicle transport along microtubule (GO:0047496)3.05658912
98mitotic sister chromatid cohesion (GO:0007064)3.05463913
99mitotic sister chromatid segregation (GO:0000070)3.04664860
100response to histamine (GO:0034776)3.04375901
101nuclear pore complex assembly (GO:0051292)3.02304254
102axon extension (GO:0048675)3.01680497
103mitotic chromosome condensation (GO:0007076)3.01202559
104regulation of vesicle fusion (GO:0031338)3.00632734
105cerebellar Purkinje cell differentiation (GO:0021702)2.98361444
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98040923
107dendrite development (GO:0016358)2.97851274
108positive regulation of synapse assembly (GO:0051965)2.97161441
109central nervous system neuron axonogenesis (GO:0021955)2.97108654
110mitotic spindle organization (GO:0007052)2.96357887
111regulation of neurotransmitter levels (GO:0001505)2.96095918
112regulation of centrosome cycle (GO:0046605)2.85143289
113cerebral cortex radially oriented cell migration (GO:0021799)2.84612825
114nuclear pore organization (GO:0006999)2.83974239
115establishment of mitochondrion localization (GO:0051654)2.83781665
116regulation of DNA endoreduplication (GO:0032875)2.82111344
117DNA unwinding involved in DNA replication (GO:0006268)2.70126283
118neuron projection extension (GO:1990138)2.65954873
119chromatin remodeling at centromere (GO:0031055)2.61865189
120meiotic chromosome segregation (GO:0045132)2.58129593
121mitotic metaphase plate congression (GO:0007080)2.57883726
122ganglion development (GO:0061548)2.57106302
123regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.54913814
124protein localization to chromosome (GO:0034502)2.53610572
125microtubule depolymerization (GO:0007019)2.52879628
126histone H2B ubiquitination (GO:0033523)2.52488806
127protein localization to chromosome, centromeric region (GO:0071459)2.51512179
128regulation of sister chromatid cohesion (GO:0007063)2.51230302
129CENP-A containing nucleosome assembly (GO:0034080)2.49343981
130regulation of centrosome duplication (GO:0010824)2.48553878
131mitochondrion transport along microtubule (GO:0047497)2.48441519
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48441519
133protein localization to microtubule cytoskeleton (GO:0072698)2.47677048
134regulation of meiosis I (GO:0060631)2.45604522
135mating behavior (GO:0007617)2.45025931
136sympathetic nervous system development (GO:0048485)2.43814190
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42455772
138glucocorticoid receptor signaling pathway (GO:0042921)2.41423807
139protein localization to kinetochore (GO:0034501)2.39668971
140kinetochore organization (GO:0051383)2.38866731
141spindle organization (GO:0007051)2.36593827
142regulation of cell cycle G2/M phase transition (GO:1902749)2.35081730
143limb bud formation (GO:0060174)2.35034399
144heterochromatin organization (GO:0070828)2.31859581
145cell fate commitment involved in formation of primary germ layer (GO:0060795)2.31654206
146metaphase plate congression (GO:0051310)2.28274580
147retinal ganglion cell axon guidance (GO:0031290)2.28115579
148protein heterotetramerization (GO:0051290)2.28093268
149positive regulation of chromosome segregation (GO:0051984)2.27547153
150regulation of spindle organization (GO:0090224)2.26165824
151behavioral response to nicotine (GO:0035095)2.24280700
152postreplication repair (GO:0006301)2.23658007
153translesion synthesis (GO:0019985)2.23636848
154regulation of axon extension involved in axon guidance (GO:0048841)2.23018586
155histone exchange (GO:0043486)2.21870443
156regulation of NFAT protein import into nucleus (GO:0051532)2.21404931
157pore complex assembly (GO:0046931)2.21189333
158positive regulation of mitotic sister chromatid separation (GO:1901970)2.20921394
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.20921394
160positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.20921394
161DNA topological change (GO:0006265)2.20752537
162DNA strand elongation involved in DNA replication (GO:0006271)2.20703408
163regulation of axon guidance (GO:1902667)2.20166248
164startle response (GO:0001964)2.19291462
165protein localization to microtubule (GO:0035372)2.18243565
166DNA strand elongation (GO:0022616)2.16319547
167spindle assembly (GO:0051225)2.15449644
168negative regulation of dendrite development (GO:2000171)2.14223610
169hemidesmosome assembly (GO:0031581)2.13492364
170apical protein localization (GO:0045176)2.12933385
171histone-serine phosphorylation (GO:0035404)2.11846387
172DNA replication-dependent nucleosome assembly (GO:0006335)2.10811020
173DNA replication-dependent nucleosome organization (GO:0034723)2.10811020
174DNA double-strand break processing (GO:0000729)2.10555850
175neuronal stem cell maintenance (GO:0097150)2.09913066
176regulation of cell maturation (GO:1903429)2.09541358
177neuron migration (GO:0001764)2.08628557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.48582229
2E2F7_22180533_ChIP-Seq_HELA_Human5.01711359
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.92513080
4GBX2_23144817_ChIP-Seq_PC3_Human3.62043858
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10608959
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05514144
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91108782
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72678445
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.67161673
10REST_21632747_ChIP-Seq_MESCs_Mouse2.67099298
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64982791
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64982791
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.55915962
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51736422
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49904950
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49272793
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42647136
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41006234
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35731511
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32639816
21AR_21572438_ChIP-Seq_LNCaP_Human2.30478791
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29413069
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28060321
24DROSHA_22980978_ChIP-Seq_HELA_Human2.25529114
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24039312
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23578702
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18924724
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14879511
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14704692
30* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13808939
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12809987
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.11114201
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06261895
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02316079
35AR_21909140_ChIP-Seq_LNCAP_Human1.99611634
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85001868
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83014682
38TAF15_26573619_Chip-Seq_HEK293_Human1.81861393
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79349730
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75632716
41EWS_26573619_Chip-Seq_HEK293_Human1.73862682
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73065578
43ZNF274_21170338_ChIP-Seq_K562_Hela1.72667256
44* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71232208
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69204995
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.67245391
47SMAD4_21799915_ChIP-Seq_A2780_Human1.64333529
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64320053
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.63933093
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63783246
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58532906
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57374529
53IGF1R_20145208_ChIP-Seq_DFB_Human1.57371252
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50941340
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.50489377
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49216526
57P300_19829295_ChIP-Seq_ESCs_Human1.47554882
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.47042471
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45152308
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44578662
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.43854658
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42993451
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.41835389
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40371878
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.39984648
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39792028
67FUS_26573619_Chip-Seq_HEK293_Human1.37610554
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.36874848
69VDR_22108803_ChIP-Seq_LS180_Human1.36172863
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35183876
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32223926
72* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31701767
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31227754
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.29652150
75* RNF2_27304074_Chip-Seq_NSC_Mouse1.29346742
76AR_25329375_ChIP-Seq_VCAP_Human1.28815853
77* STAT3_23295773_ChIP-Seq_U87_Human1.28627598
78AR_19668381_ChIP-Seq_PC3_Human1.27964658
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27680868
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23196456
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22421458
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.21755459
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21754537
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21480993
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21197577
86SOX9_26525672_Chip-Seq_HEART_Mouse1.21155424
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18985996
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.18278408
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18120150
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18020427
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17598996
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17160718
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14552797
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14030037
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14020441
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13946800
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13025715
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13000167
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.12708766
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11269426
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11088247
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11088247
103* TCF4_23295773_ChIP-Seq_U87_Human1.09245160
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09041419
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09011315
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07021414
107AHR_22903824_ChIP-Seq_MCF-7_Human1.05917056
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05505467
109ELK1_19687146_ChIP-ChIP_HELA_Human1.05349772
110RUNX2_22187159_ChIP-Seq_PCA_Human1.04674341
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.03968615
112MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03555826
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.03175991
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.03037219
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02785206
116MYC_18940864_ChIP-ChIP_HL60_Human1.02723398
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02101419
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01507963
119JUN_21703547_ChIP-Seq_K562_Human1.00757878
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00102986
121TTF2_22483619_ChIP-Seq_HELA_Human0.99702713
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99195426
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98445838
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98196974
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98193463
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97561153
127* KDM2B_26808549_Chip-Seq_K562_Human0.97215210
128TP53_16413492_ChIP-PET_HCT116_Human0.97155588
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96920711
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96754591
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96085739
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96002979
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.95524937
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95211927
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94383270
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93745438
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93618775
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.93358475
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92783412
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92701266
141MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91805745
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91542632
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91235847
144SALL1_21062744_ChIP-ChIP_HESCs_Human0.91170199
145ER_23166858_ChIP-Seq_MCF-7_Human0.90893591
146ETS1_20019798_ChIP-Seq_JURKAT_Human0.90825561
147CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90460685
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90437180
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.88519573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20629615
2MP0003880_abnormal_central_pattern4.29265672
3MP0003635_abnormal_synaptic_transmissio4.14560692
4MP0004270_analgesia3.79001045
5MP0002063_abnormal_learning/memory/cond3.47633643
6MP0009745_abnormal_behavioral_response3.24671673
7MP0005423_abnormal_somatic_nervous2.96718822
8MP0009046_muscle_twitch2.93734917
9MP0002064_seizures2.88305727
10MP0002572_abnormal_emotion/affect_behav2.75133629
11MP0001968_abnormal_touch/_nociception2.72775963
12MP0002822_catalepsy2.71766439
13MP0002734_abnormal_mechanical_nocicepti2.68811938
14MP0001486_abnormal_startle_reflex2.57031639
15MP0000778_abnormal_nervous_system2.56769439
16MP0002272_abnormal_nervous_system2.24317994
17MP0002184_abnormal_innervation2.18657871
18MP0001440_abnormal_grooming_behavior2.15167133
19MP0000569_abnormal_digit_pigmentation2.12609694
20MP0002735_abnormal_chemical_nociception2.11594597
21MP0002733_abnormal_thermal_nociception2.07528688
22MP0010094_abnormal_chromosome_stability2.04928027
23MP0003693_abnormal_embryo_hatching1.97887064
24MP0002067_abnormal_sensory_capabilities1.96898410
25MP0004811_abnormal_neuron_physiology1.96229612
26MP0002557_abnormal_social/conspecific_i1.95526180
27MP0002736_abnormal_nociception_after1.95108842
28MP0003890_abnormal_embryonic-extraembry1.93802595
29MP0005386_behavior/neurological_phenoty1.90470858
30MP0004924_abnormal_behavior1.90470858
31MP0001970_abnormal_pain_threshold1.86038769
32MP0001501_abnormal_sleep_pattern1.81676378
33MP0000579_abnormal_nail_morphology1.80462022
34MP0003937_abnormal_limbs/digits/tail_de1.79595914
35MP0003111_abnormal_nucleus_morphology1.78702864
36MP0008569_lethality_at_weaning1.76950335
37MP0001984_abnormal_olfaction1.76521041
38MP0009780_abnormal_chondrocyte_physiolo1.75131269
39MP0000955_abnormal_spinal_cord1.74419190
40MP0002877_abnormal_melanocyte_morpholog1.70458122
41MP0009053_abnormal_anal_canal1.69517504
42MP0003329_amyloid_beta_deposits1.66575593
43MP0004858_abnormal_nervous_system1.66169497
44MP0008057_abnormal_DNA_replication1.62302019
45MP0006276_abnormal_autonomic_nervous1.61092595
46MP0002909_abnormal_adrenal_gland1.60786430
47MP0001529_abnormal_vocalization1.60263957
48MP0003077_abnormal_cell_cycle1.58724703
49MP0004885_abnormal_endolymph1.52618525
50MP0002882_abnormal_neuron_morphology1.52613394
51MP0008058_abnormal_DNA_repair1.51163584
52MP0008932_abnormal_embryonic_tissue1.47997235
53MP0002066_abnormal_motor_capabilities/c1.44927987
54MP0003385_abnormal_body_wall1.44878972
55MP0003315_abnormal_perineum_morphology1.44059230
56MP0000049_abnormal_middle_ear1.43243048
57MP0002152_abnormal_brain_morphology1.41920838
58MP0003755_abnormal_palate_morphology1.41717656
59MP0004957_abnormal_blastocyst_morpholog1.40471001
60MP0002697_abnormal_eye_size1.35844937
61MP0001188_hyperpigmentation1.35803572
62MP0003787_abnormal_imprinting1.35255799
63MP0003879_abnormal_hair_cell1.33373729
64MP0008877_abnormal_DNA_methylation1.32850320
65MP0005646_abnormal_pituitary_gland1.28292926
66MP0002233_abnormal_nose_morphology1.27005023
67MP0000566_synostosis1.25688847
68MP0003935_abnormal_craniofacial_develop1.24616166
69MP0005187_abnormal_penis_morphology1.18452402
70MP0000762_abnormal_tongue_morphology1.17277982
71MP0001879_abnormal_lymphatic_vessel1.16802977
72MP0002084_abnormal_developmental_patter1.16101922
73MP0003122_maternal_imprinting1.14189280
74MP0001286_abnormal_eye_development1.13789201
75MP0000631_abnormal_neuroendocrine_gland1.12520243
76MP0000647_abnormal_sebaceous_gland1.10218939
77MP0008007_abnormal_cellular_replicative1.09971950
78MP0005645_abnormal_hypothalamus_physiol1.09079039
79MP0004742_abnormal_vestibular_system1.08748600
80MP0000428_abnormal_craniofacial_morphol1.08484043
81MP0010368_abnormal_lymphatic_system1.08089585
82MP0002085_abnormal_embryonic_tissue1.07356216
83MP0003861_abnormal_nervous_system1.07195950
84MP0006292_abnormal_olfactory_placode1.06764318
85MP0001177_atelectasis1.06534416
86MP0002177_abnormal_outer_ear1.05168343
87MP0001502_abnormal_circadian_rhythm1.00962481
88MP0003942_abnormal_urinary_system1.00953022
89MP0001293_anophthalmia1.00319482
90MP0004142_abnormal_muscle_tone1.00272879
91MP0009250_abnormal_appendicular_skeleto0.99484350
92MP0001905_abnormal_dopamine_level0.97737400
93MP0005394_taste/olfaction_phenotype0.97635839
94MP0005499_abnormal_olfactory_system0.97635839
95MP0003633_abnormal_nervous_system0.97115524
96MP0000383_abnormal_hair_follicle0.95741577
97MP0004197_abnormal_fetal_growth/weight/0.95248086
98MP0001730_embryonic_growth_arrest0.93169743
99MP0003567_abnormal_fetal_cardiomyocyte0.92880012
100MP0003631_nervous_system_phenotype0.92431808
101MP0010678_abnormal_skin_adnexa0.91315517
102MP0002938_white_spotting0.90236490
103MP0010030_abnormal_orbit_morphology0.90099597
104MP0001299_abnormal_eye_distance/0.89836577
105MP0002210_abnormal_sex_determination0.89328016
106MP0002092_abnormal_eye_morphology0.86618332
107MP0003634_abnormal_glial_cell0.86356074
108MP0001672_abnormal_embryogenesis/_devel0.86081039
109MP0005380_embryogenesis_phenotype0.86081039
110MP0001697_abnormal_embryo_size0.85585496
111MP0002069_abnormal_eating/drinking_beha0.85578781
112MP0002752_abnormal_somatic_nervous0.84805148
113MP0000350_abnormal_cell_proliferation0.84706288
114MP0002116_abnormal_craniofacial_bone0.83934968
115MP0005623_abnormal_meninges_morphology0.81445409
116MP0003632_abnormal_nervous_system0.81374232
117MP0003705_abnormal_hypodermis_morpholog0.81287480
118MP0004085_abnormal_heartbeat0.79376967
119MP0003121_genomic_imprinting0.77388525
120MP0000537_abnormal_urethra_morphology0.76560171
121MP0003137_abnormal_impulse_conducting0.75058118
122MP0001963_abnormal_hearing_physiology0.74910456
123MP0002229_neurodegeneration0.73491494
124MP0000751_myopathy0.71734700
125MP0001485_abnormal_pinna_reflex0.70910280
126MP0004233_abnormal_muscle_weight0.70401693
127MP0005409_darkened_coat_color0.70376465
128MP0002102_abnormal_ear_morphology0.69789849
129MP0001348_abnormal_lacrimal_gland0.67717905
130MP0010234_abnormal_vibrissa_follicle0.67508008
131MP0008961_abnormal_basal_metabolism0.67339175
132MP0008872_abnormal_physiological_respon0.66655589
133MP0004145_abnormal_muscle_electrophysio0.65901096
134MP0001943_abnormal_respiration0.65900520
135MP0005551_abnormal_eye_electrophysiolog0.65434779
136MP0003119_abnormal_digestive_system0.64960912
137MP0002082_postnatal_lethality0.64502644
138MP0010770_preweaning_lethality0.64502644
139MP0010769_abnormal_survival0.64418521
140MP0002751_abnormal_autonomic_nervous0.64378698
141MP0002081_perinatal_lethality0.63714525
142MP0003283_abnormal_digestive_organ0.63704449
143MP0000604_amyloidosis0.61492286
144MP0010768_mortality/aging0.60648470
145MP0000534_abnormal_ureter_morphology0.58525902
146MP0008789_abnormal_olfactory_epithelium0.56527453
147MP0003938_abnormal_ear_development0.56022834
148MP0008874_decreased_physiological_sensi0.55824774
149MP0005248_abnormal_Harderian_gland0.55443525
150MP0002234_abnormal_pharynx_morphology0.55064189
151MP0000026_abnormal_inner_ear0.54481783

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.12606564
2Myokymia (HP:0002411)5.72918404
3Focal seizures (HP:0007359)4.95891527
4Visual hallucinations (HP:0002367)4.52199322
5Epileptic encephalopathy (HP:0200134)4.03317813
6Broad-based gait (HP:0002136)3.77139970
7Progressive cerebellar ataxia (HP:0002073)3.74946420
8Mutism (HP:0002300)3.57002402
9Atonic seizures (HP:0010819)3.51658050
10Amyotrophic lateral sclerosis (HP:0007354)3.47827896
11Poor eye contact (HP:0000817)3.41696236
12Absence seizures (HP:0002121)3.36247410
13Action tremor (HP:0002345)3.35978102
14Febrile seizures (HP:0002373)3.33956146
15Excessive salivation (HP:0003781)3.31060336
16Drooling (HP:0002307)3.31060336
17Volvulus (HP:0002580)3.30821717
18Papilledema (HP:0001085)3.21610874
19Impaired vibration sensation in the lower limbs (HP:0002166)3.15401710
20Impaired social interactions (HP:0000735)3.10680804
21Abnormal social behavior (HP:0012433)3.10680804
22Ankle clonus (HP:0011448)3.09717859
23Dialeptic seizures (HP:0011146)3.05884479
24Hyperventilation (HP:0002883)3.05839624
25Supranuclear gaze palsy (HP:0000605)3.02468299
26Generalized tonic-clonic seizures (HP:0002069)3.02007778
27Limb dystonia (HP:0002451)3.00284044
28Termporal pattern (HP:0011008)2.97962880
29Insidious onset (HP:0003587)2.97962880
30Truncal ataxia (HP:0002078)2.93029719
31Gaze-evoked nystagmus (HP:0000640)2.90807439
32Urinary urgency (HP:0000012)2.89630642
33Progressive inability to walk (HP:0002505)2.88316109
34Inappropriate behavior (HP:0000719)2.86869992
35Genetic anticipation (HP:0003743)2.86536038
36Urinary bladder sphincter dysfunction (HP:0002839)2.85336080
37Abnormality of the corticospinal tract (HP:0002492)2.81723981
38Megalencephaly (HP:0001355)2.80362423
39Dysdiadochokinesis (HP:0002075)2.75350081
40Depression (HP:0000716)2.71738973
41Impaired smooth pursuit (HP:0007772)2.59690313
42Cortical dysplasia (HP:0002539)2.55845312
43Amblyopia (HP:0000646)2.54606499
44Abnormality of binocular vision (HP:0011514)2.52373723
45Diplopia (HP:0000651)2.52373723
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51920477
47Increased nuchal translucency (HP:0010880)2.50780683
48Hemiparesis (HP:0001269)2.49221002
49Abnormal eating behavior (HP:0100738)2.48356623
50Stereotypic behavior (HP:0000733)2.46933557
51Scanning speech (HP:0002168)2.46168807
52Abnormality of the lower motor neuron (HP:0002366)2.44101149
53Epileptiform EEG discharges (HP:0011182)2.44081055
54EEG with generalized epileptiform discharges (HP:0011198)2.40808782
55Dysmetria (HP:0001310)2.40639696
56Anxiety (HP:0000739)2.39973713
57Torticollis (HP:0000473)2.36324909
58Spastic gait (HP:0002064)2.35643428
59Cerebral inclusion bodies (HP:0100314)2.34874367
60Hypsarrhythmia (HP:0002521)2.34796166
61Ankyloglossia (HP:0010296)2.32650956
62Agitation (HP:0000713)2.31752803
63Aqueductal stenosis (HP:0002410)2.31592728
64Akinesia (HP:0002304)2.31250937
65Abnormality of ocular smooth pursuit (HP:0000617)2.28402901
66Inability to walk (HP:0002540)2.27360810
67Chromsome breakage (HP:0040012)2.26734527
68Absent speech (HP:0001344)2.25773050
69Polyphagia (HP:0002591)2.24487440
70High anterior hairline (HP:0009890)2.21523724
71Apathy (HP:0000741)2.21382917
72Fetal akinesia sequence (HP:0001989)2.20638477
73Obstructive sleep apnea (HP:0002870)2.18749865
74Abnormality of the labia minora (HP:0012880)2.18034028
75Pointed chin (HP:0000307)2.16281911
76Vertebral arch anomaly (HP:0008438)2.15753835
77Focal dystonia (HP:0004373)2.14232606
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.11848447
79Hypoplasia of the brainstem (HP:0002365)2.11848447
80Patellar aplasia (HP:0006443)2.10550060
81Neurofibrillary tangles (HP:0002185)2.10273649
82Cutaneous finger syndactyly (HP:0010554)2.10173703
83Abnormality of salivation (HP:0100755)2.09961894
84Birth length less than 3rd percentile (HP:0003561)2.08967572
85Lissencephaly (HP:0001339)2.06653383
86Intention tremor (HP:0002080)2.05144346
87Protruding tongue (HP:0010808)2.04279633
88Oligodactyly (hands) (HP:0001180)2.03113827
89Dysmetric saccades (HP:0000641)2.02914345
90Aplasia/Hypoplasia of the patella (HP:0006498)1.98908387
91Postural instability (HP:0002172)1.98134819
92Morphological abnormality of the middle ear (HP:0008609)1.97470533
93Shoulder girdle muscle weakness (HP:0003547)1.96967486
94Lower limb muscle weakness (HP:0007340)1.96878840
95Annular pancreas (HP:0001734)1.96223534
96Diminished motivation (HP:0000745)1.94779530
97Pachygyria (HP:0001302)1.94651637
98Impaired vibratory sensation (HP:0002495)1.93017453
99Craniofacial dystonia (HP:0012179)1.91450623
100Gait imbalance (HP:0002141)1.90812346
101Pheochromocytoma (HP:0002666)1.90035670
102Fibular aplasia (HP:0002990)1.88797498
103Lower limb asymmetry (HP:0100559)1.88657697
104Bradykinesia (HP:0002067)1.87625302
105Shawl scrotum (HP:0000049)1.86842879
106Sacral dimple (HP:0000960)1.86270282
107Sporadic (HP:0003745)1.83299446
108Type II lissencephaly (HP:0007260)1.83269237
109Oligodactyly (HP:0012165)1.82875371
110Hemiplegia (HP:0002301)1.82521502
111Lower limb amyotrophy (HP:0007210)1.82238283
112Cutaneous syndactyly (HP:0012725)1.81999263
113Specific learning disability (HP:0001328)1.81410505
114Insomnia (HP:0100785)1.80968304
115Facial hemangioma (HP:0000329)1.80468281
116Abnormal number of incisors (HP:0011064)1.80124360
117Glioma (HP:0009733)1.79976176
118Proximal placement of thumb (HP:0009623)1.79852270
119Abnormal lung lobation (HP:0002101)1.79746598
120Hepatoblastoma (HP:0002884)1.79397501
121Abnormality of the astrocytes (HP:0100707)1.79185984
122Astrocytoma (HP:0009592)1.79185984
123Medulloblastoma (HP:0002885)1.78906611
124Morphological abnormality of the pyramidal tract (HP:0002062)1.78790543
125Partial agenesis of the corpus callosum (HP:0001338)1.77687088
126Blue irides (HP:0000635)1.77652896
127Retinal dysplasia (HP:0007973)1.75939180
128Cerebellar dysplasia (HP:0007033)1.73798562
129Meckel diverticulum (HP:0002245)1.73436833
130Midline defect of the nose (HP:0004122)1.73106033
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.72131773
132Large earlobe (HP:0009748)1.69675771
133Deviation of the thumb (HP:0009603)1.69172349
134Short 4th metacarpal (HP:0010044)1.67498025
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67498025
136Abnormality of chromosome segregation (HP:0002916)1.67134284
137Small hand (HP:0200055)1.66262159
138Abnormality of the ileum (HP:0001549)1.64684524
139Absent forearm bone (HP:0003953)1.64555577
140Aplasia involving forearm bones (HP:0009822)1.64555577
141Aplasia/Hypoplasia of the nipples (HP:0006709)1.64228758
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62670285
143Heterotopia (HP:0002282)1.62311930
144Abnormality of the ischium (HP:0003174)1.62254391
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.61451014
146Abnormality of the 4th metacarpal (HP:0010012)1.61026823
147Abnormality of the carotid arteries (HP:0005344)1.60990291
148Atrophic scars (HP:0001075)1.60933548
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.60127304
150Absent radius (HP:0003974)1.60090252
151Ectopic kidney (HP:0000086)1.60029962
152Papillary thyroid carcinoma (HP:0002895)1.59905307
153Colon cancer (HP:0003003)1.58358769
154Gastroesophageal reflux (HP:0002020)1.57482533
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.56238845
156Ulnar bowing (HP:0003031)1.55783888
157Split foot (HP:0001839)1.53240796
158Absent eyebrow (HP:0002223)1.53030808
159Elfin facies (HP:0004428)1.51907920
160Micropenis (HP:0000054)1.51462166
161Optic nerve hypoplasia (HP:0000609)1.50678926
162Fibular hypoplasia (HP:0003038)1.50654390
163Morphological abnormality of the inner ear (HP:0011390)1.49945883
164Smooth philtrum (HP:0000319)1.49345696
165Tibial bowing (HP:0002982)1.46721926
166Polymicrogyria (HP:0002126)1.46124943
167Cystic hygroma (HP:0000476)1.45421798
168Small intestinal stenosis (HP:0012848)1.44731026
169Duodenal stenosis (HP:0100867)1.44731026
170Esophageal atresia (HP:0002032)1.44369533
171Neonatal short-limb short stature (HP:0008921)1.44018592
172Short tibia (HP:0005736)1.43561402
173Gastrointestinal atresia (HP:0002589)1.41707601
174Abnormality of cochlea (HP:0000375)1.41027911
175Atresia of the external auditory canal (HP:0000413)1.39273620
176Abnormality of chromosome stability (HP:0003220)1.38707662
177Thickened helices (HP:0000391)1.38200712
178Exotropia (HP:0000577)1.37974245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.12189558
2EPHA43.66046317
3NTRK33.62541728
4MAP3K93.54230511
5MAP3K43.15366355
6MINK12.76292937
7NTRK22.53017414
8MAP2K72.44534497
9WEE12.24756594
10KSR12.18528755
11DAPK22.13313299
12PAK62.10063482
13BUB11.91855061
14TSSK61.91276772
15CDC71.90636040
16MAPK131.87130016
17CASK1.86622424
18SRPK11.82939574
19SIK21.81775294
20CAMKK11.75068708
21KSR21.73447611
22TAF11.68683512
23MAP2K41.63676016
24MKNK21.57443742
25TTK1.51868886
26PLK21.51232118
27CDK51.50257130
28NTRK11.50246359
29PHKG21.49211015
30PHKG11.49211015
31PNCK1.48790084
32PBK1.46403451
33ERBB31.46194253
34LATS21.36537536
35MAP3K121.31545512
36RIPK41.29555579
37TNIK1.29341867
38DAPK11.28242647
39DYRK21.26503203
40PRKD31.24865080
41SCYL21.23732258
42ERBB41.22344473
43MKNK11.21844559
44TYRO31.20940482
45CAMKK21.20411124
46CSNK1G21.19970743
47MET1.19960156
48PLK11.09744034
49MOS1.09466417
50CHEK21.08855200
51UHMK11.08339698
52PRKCG1.08123713
53PLK41.05647382
54TRIM281.02605836
55BRSK21.00738008
56MAP3K20.99522641
57CDK180.97375133
58NEK20.96434668
59RET0.96257768
60CCNB10.95639396
61CDK140.95245531
62STK110.93892351
63CDK150.93576555
64DYRK1A0.91888736
65CDK190.89636330
66PRPF4B0.88642942
67AURKA0.88096345
68MAP3K100.86191456
69GRK50.85813160
70TAOK10.85072850
71BRAF0.84043515
72CDK80.83319322
73PAK30.82340073
74CDK11A0.80763422
75RAF10.80354542
76CAMK2A0.78254777
77FES0.77855027
78MST1R0.77482137
79BMPR1B0.76837430
80FGFR20.76365471
81MARK20.74406705
82STK380.72570051
83ATR0.71180874
84STK30.69139867
85WNK30.69125431
86MAPKAPK50.68675979
87STK38L0.68321206
88SGK10.66053474
89AURKB0.64662173
90CSNK1G30.64233278
91PDGFRA0.63388199
92WNK40.63065618
93BCR0.61755549
94PRKCZ0.61730063
95SGK2230.61637113
96SGK4940.61637113
97ARAF0.61564247
98ZAK0.61306325
99MAP3K60.60874735
100CAMK2B0.60100880
101CDK70.59501462
102ATM0.59257687
103BRD40.58935230
104SGK20.58763504
105ALK0.58584312
106RPS6KA20.55977623
107NEK10.55506521
108CSNK1A1L0.55282552
109EIF2AK10.54428227
110LIMK10.54174865
111CDK10.52433712
112LATS10.51689891
113PKN10.51132923
114CDK30.50478473
115EIF2AK30.49790300
116FYN0.49060034
117EIF2AK20.48661843
118PRKCH0.48199284
119CHEK10.48052470
120PTK20.47448953
121BMPR20.47413424
122BRSK10.46143874
123RPS6KA30.45426771
124CDK90.44834239
125STK390.44697311
126YES10.43828318
127CDK120.43089804
128RPS6KA40.42505885
129RIPK10.42415665
130CAMK1G0.42345600
131CAMK10.41960464
132MAPK100.41435070
133SGK30.41200547
134SIK30.40668537
135PRKCE0.39030353
136ICK0.38320969
137CDK20.38115137
138EPHB20.37565207
139NEK90.37404975
140CSNK1G10.37176085
141FGR0.34512967
142MAPK90.34047837
143PLK30.32081798
144PDK10.31547108
145PRKCB0.31427157
146MAPK80.30782822
147CSNK1D0.29319468
148PTK2B0.29219276
149CSNK1E0.28665557
150ROCK20.27066705
151MAPK120.25996850
152GSK3B0.25943884

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55815518
2Synaptic vesicle cycle_Homo sapiens_hsa047212.76302057
3Olfactory transduction_Homo sapiens_hsa047402.70665311
4Long-term potentiation_Homo sapiens_hsa047202.64068786
5Cell cycle_Homo sapiens_hsa041102.61569390
6Circadian entrainment_Homo sapiens_hsa047132.58396289
7Glutamatergic synapse_Homo sapiens_hsa047242.55239966
8GABAergic synapse_Homo sapiens_hsa047272.55056671
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54460309
10Morphine addiction_Homo sapiens_hsa050322.43755183
11DNA replication_Homo sapiens_hsa030302.43613408
12Amphetamine addiction_Homo sapiens_hsa050312.36389179
13Dopaminergic synapse_Homo sapiens_hsa047282.31877422
14RNA transport_Homo sapiens_hsa030132.22067619
15Basal transcription factors_Homo sapiens_hsa030222.20751890
16Mismatch repair_Homo sapiens_hsa034302.03495766
17Cholinergic synapse_Homo sapiens_hsa047251.96016675
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94910126
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94494927
20Fanconi anemia pathway_Homo sapiens_hsa034601.91481981
21Salivary secretion_Homo sapiens_hsa049701.91006522
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81487966
23Cocaine addiction_Homo sapiens_hsa050301.79376325
24Protein export_Homo sapiens_hsa030601.79148599
25Long-term depression_Homo sapiens_hsa047301.79050503
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76740112
27Renin secretion_Homo sapiens_hsa049241.72133268
28Homologous recombination_Homo sapiens_hsa034401.70242551
29Gastric acid secretion_Homo sapiens_hsa049711.67123220
30Non-homologous end-joining_Homo sapiens_hsa034501.66962512
31mRNA surveillance pathway_Homo sapiens_hsa030151.66906156
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66501143
33Base excision repair_Homo sapiens_hsa034101.65769421
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65294799
35Spliceosome_Homo sapiens_hsa030401.64714017
36Oxytocin signaling pathway_Homo sapiens_hsa049211.64701713
37Taste transduction_Homo sapiens_hsa047421.64092186
38Serotonergic synapse_Homo sapiens_hsa047261.63372190
39Gap junction_Homo sapiens_hsa045401.62694797
40Axon guidance_Homo sapiens_hsa043601.62467693
41Insulin secretion_Homo sapiens_hsa049111.59519612
42Nucleotide excision repair_Homo sapiens_hsa034201.47855628
43GnRH signaling pathway_Homo sapiens_hsa049121.43991469
44Steroid biosynthesis_Homo sapiens_hsa001001.43352888
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38171140
46Glioma_Homo sapiens_hsa052141.37735440
47Basal cell carcinoma_Homo sapiens_hsa052171.37575492
48Calcium signaling pathway_Homo sapiens_hsa040201.36415226
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35500025
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34415897
51ErbB signaling pathway_Homo sapiens_hsa040121.30511050
52Estrogen signaling pathway_Homo sapiens_hsa049151.29634438
53Oocyte meiosis_Homo sapiens_hsa041141.25964168
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25909766
55One carbon pool by folate_Homo sapiens_hsa006701.24469769
56MicroRNAs in cancer_Homo sapiens_hsa052061.22982112
57cAMP signaling pathway_Homo sapiens_hsa040241.19423123
58RNA polymerase_Homo sapiens_hsa030201.18505773
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17339000
60Type II diabetes mellitus_Homo sapiens_hsa049301.16820310
61Melanogenesis_Homo sapiens_hsa049161.13889372
62Pyrimidine metabolism_Homo sapiens_hsa002401.09818816
63Endometrial cancer_Homo sapiens_hsa052131.04446629
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02463675
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02161862
66RNA degradation_Homo sapiens_hsa030181.01531198
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01307971
68p53 signaling pathway_Homo sapiens_hsa041150.99381112
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95935080
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91525334
71Collecting duct acid secretion_Homo sapiens_hsa049660.91197651
72Selenocompound metabolism_Homo sapiens_hsa004500.90602871
73TGF-beta signaling pathway_Homo sapiens_hsa043500.90405232
74Colorectal cancer_Homo sapiens_hsa052100.90319357
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89366784
76Adherens junction_Homo sapiens_hsa045200.88869513
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88743091
78Alcoholism_Homo sapiens_hsa050340.88459799
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.87809355
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86399074
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.84950609
82Dorso-ventral axis formation_Homo sapiens_hsa043200.84317871
83VEGF signaling pathway_Homo sapiens_hsa043700.83359564
84mTOR signaling pathway_Homo sapiens_hsa041500.81921568
85Bladder cancer_Homo sapiens_hsa052190.81522092
86Small cell lung cancer_Homo sapiens_hsa052220.81396781
87Renal cell carcinoma_Homo sapiens_hsa052110.80310621
88Phototransduction_Homo sapiens_hsa047440.80310583
89Non-small cell lung cancer_Homo sapiens_hsa052230.80152583
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79716162
91Choline metabolism in cancer_Homo sapiens_hsa052310.78432506
92ECM-receptor interaction_Homo sapiens_hsa045120.77521936
93MAPK signaling pathway_Homo sapiens_hsa040100.77474924
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.74467460
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72865597
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72088416
97Wnt signaling pathway_Homo sapiens_hsa043100.70173034
98Thyroid hormone synthesis_Homo sapiens_hsa049180.68018903
99Cardiac muscle contraction_Homo sapiens_hsa042600.67795941
100Dilated cardiomyopathy_Homo sapiens_hsa054140.67716953
101Vitamin B6 metabolism_Homo sapiens_hsa007500.64850380
102Vibrio cholerae infection_Homo sapiens_hsa051100.64493909
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.64227905
104Ras signaling pathway_Homo sapiens_hsa040140.63404274
105Rap1 signaling pathway_Homo sapiens_hsa040150.63303257
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62213203
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62176302
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61229636
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60213569
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59647305
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59175441
112Pancreatic secretion_Homo sapiens_hsa049720.57719891
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57286190
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56274955
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56095624
116Purine metabolism_Homo sapiens_hsa002300.55101642
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55038319
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54965667
119Insulin signaling pathway_Homo sapiens_hsa049100.53884236
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53862585
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.53617928
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53561653
123Glucagon signaling pathway_Homo sapiens_hsa049220.50056701
124Pathways in cancer_Homo sapiens_hsa052000.49169812
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47634990
126Endocytosis_Homo sapiens_hsa041440.46987982
127Hippo signaling pathway_Homo sapiens_hsa043900.46931234
128Prostate cancer_Homo sapiens_hsa052150.45564323
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44962849
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43261683
131Focal adhesion_Homo sapiens_hsa045100.42846973
132Proteoglycans in cancer_Homo sapiens_hsa052050.41907013
133Hedgehog signaling pathway_Homo sapiens_hsa043400.41631878
134Prolactin signaling pathway_Homo sapiens_hsa049170.40573455
135Chemokine signaling pathway_Homo sapiens_hsa040620.40302628
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39231389
137Melanoma_Homo sapiens_hsa052180.38842518
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38118048
139Pancreatic cancer_Homo sapiens_hsa052120.37784705
140Type I diabetes mellitus_Homo sapiens_hsa049400.37257468
141Folate biosynthesis_Homo sapiens_hsa007900.35744571
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34508356
143Inositol phosphate metabolism_Homo sapiens_hsa005620.33819311
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33756043
145Tight junction_Homo sapiens_hsa045300.33710446
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33093047
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.32911740
148Ovarian steroidogenesis_Homo sapiens_hsa049130.31569669
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31240401

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