NES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)5.90495285
2glomerular visceral epithelial cell development (GO:0072015)5.79508013
3glomerular epithelial cell development (GO:0072310)5.55172060
4muscle cell fate commitment (GO:0042693)5.29919992
5plasma membrane repair (GO:0001778)4.87023458
6myoblast fusion (GO:0007520)4.81839935
7paraxial mesoderm development (GO:0048339)4.36510498
8syncytium formation by plasma membrane fusion (GO:0000768)4.35888337
9syncytium formation (GO:0006949)4.29220786
10hippo signaling (GO:0035329)4.21004555
11skeletal muscle fiber development (GO:0048741)4.05548909
12positive regulation of myotube differentiation (GO:0010831)3.94546933
13actin-myosin filament sliding (GO:0033275)3.85814879
14muscle filament sliding (GO:0030049)3.85814879
15axonal fasciculation (GO:0007413)3.83086534
16cell adhesion mediated by integrin (GO:0033627)3.79435437
17pyrimidine nucleobase catabolic process (GO:0006208)3.67763065
18postsynaptic membrane organization (GO:0001941)3.67609541
19convergent extension (GO:0060026)3.64528122
20neuron recognition (GO:0008038)3.59356217
21positive regulation of skeletal muscle tissue development (GO:0048643)3.58903343
22regulation of hippo signaling (GO:0035330)3.56909077
23camera-type eye morphogenesis (GO:0048593)3.56824651
24lateral sprouting from an epithelium (GO:0060601)3.53602186
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48225353
26glomerulus development (GO:0032835)3.47977806
27actin-mediated cell contraction (GO:0070252)3.32858496
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.30430557
29axon extension involved in axon guidance (GO:0048846)3.30250569
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.30250569
31basement membrane organization (GO:0071711)3.29792556
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.29709105
33presynaptic membrane assembly (GO:0097105)3.27593654
34myotube cell development (GO:0014904)3.27524421
35positive regulation of myoblast differentiation (GO:0045663)3.26810874
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25303356
37peripheral nervous system axon ensheathment (GO:0032292)3.22169335
38myelination in peripheral nervous system (GO:0022011)3.22169335
39renal filtration (GO:0097205)3.21274488
40Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.20946744
41tongue development (GO:0043586)3.19546200
42apical protein localization (GO:0045176)3.18404637
43regulation of axon extension involved in axon guidance (GO:0048841)3.17087979
44sarcomere organization (GO:0045214)3.16527292
45chondrocyte proliferation (GO:0035988)3.14798437
46presynaptic membrane organization (GO:0097090)3.13223456
47notochord development (GO:0030903)3.13176513
48lens fiber cell development (GO:0070307)3.12625429
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.12463481
50endocardial cushion morphogenesis (GO:0003203)3.10457207
51G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08629817
52regulation of establishment of planar polarity (GO:0090175)3.07035878
53negative regulation of cell size (GO:0045792)3.06968704
54coronary vasculature morphogenesis (GO:0060977)3.05857035
55regulation of protein heterodimerization activity (GO:0043497)3.04375569
56branching involved in salivary gland morphogenesis (GO:0060445)3.03389243
57cerebral cortex radially oriented cell migration (GO:0021799)3.03330407
58cell migration in hindbrain (GO:0021535)3.02663045
59cell migration involved in sprouting angiogenesis (GO:0002042)3.02443757
60epithelial cell-cell adhesion (GO:0090136)3.00124505
61striated muscle atrophy (GO:0014891)2.99674185
62actin filament-based movement (GO:0030048)2.99199399
63vascular endothelial growth factor signaling pathway (GO:0038084)2.97085300
64endodermal cell differentiation (GO:0035987)2.96884046
65skeletal muscle contraction (GO:0003009)2.96637352
66regulation of axon guidance (GO:1902667)2.96409124
67semaphorin-plexin signaling pathway (GO:0071526)2.94975852
68negative regulation of chondrocyte differentiation (GO:0032331)2.92124377
69adherens junction assembly (GO:0034333)2.89585566
70axon extension (GO:0048675)2.89155965
71establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.88361891
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.88349832
73mesenchyme morphogenesis (GO:0072132)2.87842260
74embryonic foregut morphogenesis (GO:0048617)2.87687621
75wound healing, spreading of epidermal cells (GO:0035313)2.87296196
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.82466871
77polarized epithelial cell differentiation (GO:0030859)2.82084269
78outer ear morphogenesis (GO:0042473)2.82035686
79establishment or maintenance of bipolar cell polarity (GO:0061245)2.81880713
80establishment or maintenance of apical/basal cell polarity (GO:0035088)2.81880713
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80216542
82venous blood vessel morphogenesis (GO:0048845)2.79658343
83establishment of tissue polarity (GO:0007164)2.78425692
84establishment of planar polarity (GO:0001736)2.78425692
85response to inactivity (GO:0014854)2.78284426
86non-canonical Wnt signaling pathway (GO:0035567)2.77225539
87spinal cord development (GO:0021510)2.75435877
88myotube differentiation (GO:0014902)2.73985549
89lymphangiogenesis (GO:0001946)2.72746192
90glomerular filtration (GO:0003094)2.72575553
91NLS-bearing protein import into nucleus (GO:0006607)2.71501474
92musculoskeletal movement (GO:0050881)2.70422257
93multicellular organismal movement (GO:0050879)2.70422257
94heart valve formation (GO:0003188)2.68150042
95somatic stem cell division (GO:0048103)2.67712582
96embryonic viscerocranium morphogenesis (GO:0048703)2.66951810
97myofibril assembly (GO:0030239)2.66869935
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66275267
99cellular response to prostaglandin stimulus (GO:0071379)2.66029936
100positive regulation of neuroblast proliferation (GO:0002052)2.65632799
101forebrain development (GO:0030900)2.64980426
102stress fiber assembly (GO:0043149)2.64612989
103striated muscle cell proliferation (GO:0014855)2.64466152
104Notch signaling involved in heart development (GO:0061314)2.64074750
105cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63576542
106morphogenesis of an epithelial sheet (GO:0002011)2.63295820
107actomyosin structure organization (GO:0031032)2.62982016
108epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62191993
109protein heterotrimerization (GO:0070208)2.61692537
110establishment of nucleus localization (GO:0040023)2.61221603
111nucleobase catabolic process (GO:0046113)2.60370815
112mRNA transcription from RNA polymerase II promoter (GO:0042789)2.59773597
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59463598
114neuromuscular junction development (GO:0007528)2.59102424
115mesenchymal to epithelial transition (GO:0060231)2.58878755
116negative regulation of catenin import into nucleus (GO:0035414)2.58369061
117mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57888634
118regulation of p38MAPK cascade (GO:1900744)2.57141046
119lens morphogenesis in camera-type eye (GO:0002089)2.57042800
120cochlea morphogenesis (GO:0090103)2.56998958
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56581207
122body morphogenesis (GO:0010171)2.56452662
123positive regulation of muscle cell differentiation (GO:0051149)2.54891916
124kidney mesenchyme development (GO:0072074)2.54099379
125lung epithelium development (GO:0060428)2.53826078
126mRNA transcription (GO:0009299)2.53668158
127adherens junction organization (GO:0034332)2.53361075
128negative regulation of smooth muscle cell migration (GO:0014912)2.52916116
129positive regulation of epithelial to mesenchymal transition (GO:0010718)2.52754475
130positive regulation of histone deacetylation (GO:0031065)2.52476634
131positive regulation of astrocyte differentiation (GO:0048711)2.51345629
132collagen fibril organization (GO:0030199)2.50617492
133neural tube development (GO:0021915)2.50506935
134metanephric mesenchyme development (GO:0072075)2.50184975
135lung-associated mesenchyme development (GO:0060484)2.49903017
136muscle cell cellular homeostasis (GO:0046716)2.49776583
137cell communication by electrical coupling (GO:0010644)2.48629955
138asymmetric protein localization (GO:0008105)2.48537144
139negative regulation of fatty acid transport (GO:2000192)2.48302658
140positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.47803155
141neuronal stem cell maintenance (GO:0097150)2.47391370
142positive regulation of synapse assembly (GO:0051965)2.46393292
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.45905783
144layer formation in cerebral cortex (GO:0021819)2.45820896
145regulation of NFAT protein import into nucleus (GO:0051532)2.45555541
146central nervous system projection neuron axonogenesis (GO:0021952)2.45138389
147suckling behavior (GO:0001967)2.45006096
148regulation of endothelial cell chemotaxis (GO:2001026)2.44952038
149renal system development (GO:0072001)2.44535834
150astrocyte development (GO:0014002)2.44427683
151cardiac myofibril assembly (GO:0055003)2.44313532
152cardiac muscle cell proliferation (GO:0060038)2.43390595
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43180805
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42804637
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.42507667
156epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41031882
157heart morphogenesis (GO:0003007)2.40312698
158artery development (GO:0060840)2.36540893
159post-anal tail morphogenesis (GO:0036342)2.36271181
160dendrite morphogenesis (GO:0048813)2.36159408
161eye morphogenesis (GO:0048592)2.35392717
162limb development (GO:0060173)2.34637813
163appendage development (GO:0048736)2.34637813
164regulation of catenin import into nucleus (GO:0035412)2.32972190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06946635
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.19975444
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.38274776
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.53043463
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16706075
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97087803
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.91745820
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88101517
9* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.66866919
10CLOCK_20551151_ChIP-Seq_293T_Human2.62434918
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.55543326
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50248250
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48742640
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46413390
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43760014
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.41728064
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.38112978
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34452469
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29627223
20* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24137725
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.23713390
22* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15939780
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14165129
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13684123
25* WT1_19549856_ChIP-ChIP_CCG9911_Human2.10974512
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10542074
27ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07942446
28* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04162362
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.03854472
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.03486627
31* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96291066
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92627193
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91478515
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90034556
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.89025849
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88169377
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88169377
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88169377
39* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87732585
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86098228
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84833325
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84142816
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81179062
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.80082959
45* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76801495
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.76556574
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75953344
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75539512
49* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75097630
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.73305283
51* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71983042
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71649731
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.71576542
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70175406
55KDM2B_26808549_Chip-Seq_K562_Human1.69207461
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.69170886
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.66383791
58KDM2B_26808549_Chip-Seq_DND41_Human1.64898952
59BRD4_25478319_ChIP-Seq_HGPS_Human1.60499220
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60324076
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.58552037
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58111159
63TP53_22127205_ChIP-Seq_IMR90_Human1.55554424
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54203967
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53521377
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.51311906
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.50232767
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48613986
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47507861
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.45166347
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44644744
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.40432913
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.40432913
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.38586222
75* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38571134
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38372460
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36692741
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36529607
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36314176
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34801971
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34688068
82* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34396226
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34366085
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.33825622
85ATF3_27146783_Chip-Seq_COLON_Human1.31656231
86AR_21909140_ChIP-Seq_LNCAP_Human1.30561140
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.30193938
88RACK7_27058665_Chip-Seq_MCF-7_Human1.28185743
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27360781
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.27159196
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26871054
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26257553
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.26203086
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.25559738
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25175479
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25130038
97TCF7_22412390_ChIP-Seq_EML_Mouse1.24812981
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24411412
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24329853
100ZNF263_19887448_ChIP-Seq_K562_Human1.24177995
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22396361
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.21493437
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20524148
104E2F7_22180533_ChIP-Seq_HELA_Human1.20003585
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18463361
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15917541
107MYC_22102868_ChIP-Seq_BL_Human1.15711249
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15391988
109* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14836169
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14490249
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13970251
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13500820
113* LXR_22292898_ChIP-Seq_THP-1_Human1.12966075
114* TP53_23651856_ChIP-Seq_MEFs_Mouse1.12036843
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11799496
116RNF2_27304074_Chip-Seq_NSC_Mouse1.11335123
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11161406
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10089406
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10089406
120NANOG_16153702_ChIP-ChIP_HESCs_Human1.09536552
121* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09514884
122DROSHA_22980978_ChIP-Seq_HELA_Human1.09121412
123CJUN_26792858_Chip-Seq_BT549_Human1.08884006
124GBX2_23144817_ChIP-Seq_PC3_Human1.07850318
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07632031
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07274386
127* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06007829
128* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05527056
129* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05527056
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05270389
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04983246
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04545284
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03657601
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03572906
135SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03356564
136SOX2_16153702_ChIP-ChIP_HESCs_Human1.01455201
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01338623
138* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00448419
139* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00432499
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98420703
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97870945
142* CTCF_27219007_Chip-Seq_Bcells_Human0.97798324
143RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97272589
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.96414086
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95871856
146* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95465484
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94689281
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93961160
149SOX9_26525672_Chip-Seq_HEART_Mouse0.92139586
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89977176
151ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89290318
152REST_21632747_ChIP-Seq_MESCs_Mouse0.88126216
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.88066973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology3.80729541
2MP0010030_abnormal_orbit_morphology3.68955742
3MP0000733_abnormal_muscle_development3.26829757
4MP0004272_abnormal_basement_membrane3.18854399
5MP0003705_abnormal_hypodermis_morpholog2.92606009
6MP0000750_abnormal_muscle_regeneration2.74370220
7MP0000751_myopathy2.49161664
8MP0004084_abnormal_cardiac_muscle2.32266315
9MP0000537_abnormal_urethra_morphology2.31275018
10MP0008438_abnormal_cutaneous_collagen2.30212097
11MP0000749_muscle_degeneration2.22976274
12MP0004859_abnormal_synaptic_plasticity2.08345132
13MP0002249_abnormal_larynx_morphology2.05234732
14MP0003283_abnormal_digestive_organ2.03364468
15MP0006292_abnormal_olfactory_placode2.00548973
16MP0003136_yellow_coat_color1.98947556
17MP0010368_abnormal_lymphatic_system1.95158120
18MP0004087_abnormal_muscle_fiber1.83847922
19MP0003942_abnormal_urinary_system1.80581405
20MP0003091_abnormal_cell_migration1.76193573
21MP0000428_abnormal_craniofacial_morphol1.75230492
22MP0003566_abnormal_cell_adhesion1.73960745
23MP0004270_analgesia1.72294807
24MP0003279_aneurysm1.70304535
25MP0010352_gastrointestinal_tract_polyps1.69930923
26MP0000747_muscle_weakness1.68639721
27MP0009053_abnormal_anal_canal1.67807756
28MP0009379_abnormal_foot_pigmentation1.67686452
29MP0005076_abnormal_cell_differentiation1.66839300
30MP0003385_abnormal_body_wall1.63667162
31MP0000759_abnormal_skeletal_muscle1.63227344
32MP0004233_abnormal_muscle_weight1.61796016
33MP0009780_abnormal_chondrocyte_physiolo1.61681509
34MP0003115_abnormal_respiratory_system1.56724117
35MP0003941_abnormal_skin_development1.54962879
36MP0002932_abnormal_joint_morphology1.52367586
37MP0005248_abnormal_Harderian_gland1.51998132
38MP0002108_abnormal_muscle_morphology1.50642181
39MP0001299_abnormal_eye_distance/1.47402473
40MP0003755_abnormal_palate_morphology1.46977466
41MP0008789_abnormal_olfactory_epithelium1.46787472
42MP0000534_abnormal_ureter_morphology1.42531766
43MP0000955_abnormal_spinal_cord1.41911881
44MP0002106_abnormal_muscle_physiology1.41335803
45MP0000049_abnormal_middle_ear1.40643730
46MP0005503_abnormal_tendon_morphology1.39704651
47MP0005394_taste/olfaction_phenotype1.39526421
48MP0005499_abnormal_olfactory_system1.39526421
49MP0002184_abnormal_innervation1.37943736
50MP0002269_muscular_atrophy1.37361656
51MP0004145_abnormal_muscle_electrophysio1.36492754
52MP0004197_abnormal_fetal_growth/weight/1.33304728
53MP0003935_abnormal_craniofacial_develop1.32844689
54MP0010630_abnormal_cardiac_muscle1.32133665
55MP0002697_abnormal_eye_size1.30578877
56MP0003937_abnormal_limbs/digits/tail_de1.29760925
57MP0004858_abnormal_nervous_system1.29481937
58MP0000767_abnormal_smooth_muscle1.29136234
59MP0005369_muscle_phenotype1.28702937
60MP0005257_abnormal_intraocular_pressure1.28396682
61MP0009250_abnormal_appendicular_skeleto1.28040245
62MP0005171_absent_coat_pigmentation1.26375784
63MP0002233_abnormal_nose_morphology1.26295258
64MP0002234_abnormal_pharynx_morphology1.26038458
65MP0005409_darkened_coat_color1.23431859
66MP0005508_abnormal_skeleton_morphology1.23158333
67MP0002084_abnormal_developmental_patter1.19668291
68MP0003950_abnormal_plasma_membrane1.18912497
69MP0002653_abnormal_ependyma_morphology1.18434582
70MP0002282_abnormal_trachea_morphology1.18169431
71MP0001915_intracranial_hemorrhage1.16697217
72MP0002925_abnormal_cardiovascular_devel1.14939353
73MP0009278_abnormal_bone_marrow1.12462396
74MP0002085_abnormal_embryonic_tissue1.12412300
75MP0001958_emphysema1.11608173
76MP0000432_abnormal_head_morphology1.11181734
77MP0002092_abnormal_eye_morphology1.10080122
78MP0001849_ear_inflammation1.09952375
79MP0003938_abnormal_ear_development1.09302511
80MP0002152_abnormal_brain_morphology1.08736397
81MP0002116_abnormal_craniofacial_bone1.08452636
82MP0003121_genomic_imprinting1.06892632
83MP0005330_cardiomyopathy1.06671406
84MP0005275_abnormal_skin_tensile1.06477791
85MP0002114_abnormal_axial_skeleton1.04131694
86MP0002938_white_spotting1.02935983
87MP0001879_abnormal_lymphatic_vessel1.02799079
88MP0003122_maternal_imprinting1.01978120
89MP0009384_cardiac_valve_regurgitation1.01460634
90MP0005377_hearing/vestibular/ear_phenot1.00877071
91MP0003878_abnormal_ear_physiology1.00877071
92MP0004133_heterotaxia1.00133622
93MP0000762_abnormal_tongue_morphology0.99673031
94MP0003984_embryonic_growth_retardation0.99511179
95MP0003119_abnormal_digestive_system0.99149285
96MP0002088_abnormal_embryonic_growth/wei0.98412304
97MP0005423_abnormal_somatic_nervous0.98337785
98MP0001614_abnormal_blood_vessel0.98006499
99MP0005380_embryogenesis_phenotype0.97616619
100MP0001672_abnormal_embryogenesis/_devel0.97616619
101MP0004036_abnormal_muscle_relaxation0.97090815
102MP0006138_congestive_heart_failure0.96937858
103MP0002128_abnormal_blood_circulation0.96872224
104MP0000566_synostosis0.95483720
105MP0000163_abnormal_cartilage_morphology0.95064225
106MP0002089_abnormal_postnatal_growth/wei0.93543056
107MP0000026_abnormal_inner_ear0.90628458
108MP0001286_abnormal_eye_development0.90340453
109MP0002882_abnormal_neuron_morphology0.89826316
110MP0005197_abnormal_uvea_morphology0.89679391
111MP0004885_abnormal_endolymph0.89676053
112MP0002877_abnormal_melanocyte_morpholog0.89502538
113MP0005620_abnormal_muscle_contractility0.88994007
114MP0003634_abnormal_glial_cell0.88780779
115MP0002081_perinatal_lethality0.87220384
116MP0001293_anophthalmia0.87154724
117MP0003861_abnormal_nervous_system0.87133501
118MP0003890_abnormal_embryonic-extraembry0.87069596
119MP0001730_embryonic_growth_arrest0.86978081
120MP0002086_abnormal_extraembryonic_tissu0.86354687
121MP0000266_abnormal_heart_morphology0.85926111
122MP0000778_abnormal_nervous_system0.84977781
123MP0002896_abnormal_bone_mineralization0.84745035
124MP0001697_abnormal_embryo_size0.83873867
125MP0002734_abnormal_mechanical_nocicepti0.83322060
126MP0005023_abnormal_wound_healing0.82588714
127MP0005187_abnormal_penis_morphology0.81710383
128MP0002111_abnormal_tail_morphology0.81581951
129MP0005391_vision/eye_phenotype0.81201985
130MP0002752_abnormal_somatic_nervous0.79676084
131MP0002751_abnormal_autonomic_nervous0.78526080

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the musculature (HP:0100854)4.93218206
2Popliteal pterygium (HP:0009756)4.74045649
3Fetal akinesia sequence (HP:0001989)4.64747542
4Round ear (HP:0100830)4.13380164
5Malignant hyperthermia (HP:0002047)4.08298999
6Pterygium (HP:0001059)3.94409658
7Abnormality of placental membranes (HP:0011409)3.87603193
8Amniotic constriction ring (HP:0009775)3.87603193
9Difficulty running (HP:0009046)3.83779604
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.80594915
11Difficulty climbing stairs (HP:0003551)3.46969424
12Distal arthrogryposis (HP:0005684)3.46582912
13Muscle fiber inclusion bodies (HP:0100299)3.46553775
14Type 1 muscle fiber predominance (HP:0003803)3.36324722
15Neonatal short-limb short stature (HP:0008921)3.36270574
16Thin ribs (HP:0000883)3.33747430
17Akinesia (HP:0002304)3.27197979
18Type 2 muscle fiber atrophy (HP:0003554)3.17178667
19Ulnar deviation of the wrist (HP:0003049)3.15275340
20Muscle fiber splitting (HP:0003555)3.08208999
21Hip contracture (HP:0003273)3.07929661
22Nemaline bodies (HP:0003798)3.07706892
23Calcaneovalgus deformity (HP:0001848)3.07317722
24Muscle fiber atrophy (HP:0100295)3.04493669
25Protrusio acetabuli (HP:0003179)3.01729158
26Septo-optic dysplasia (HP:0100842)3.00528300
27Increased connective tissue (HP:0009025)2.96094171
28Abnormality of the neuromuscular junction (HP:0003398)2.94549191
29Fatigable weakness (HP:0003473)2.94549191
30Shallow orbits (HP:0000586)2.88034581
31Mildly elevated creatine phosphokinase (HP:0008180)2.86053047
32Aplasia/Hypoplasia involving the musculature (HP:0001460)2.82357787
33Gowers sign (HP:0003391)2.81985299
34Absent phalangeal crease (HP:0006109)2.75897519
35Premature rupture of membranes (HP:0001788)2.75565719
36Deformed tarsal bones (HP:0008119)2.73998262
37Weak cry (HP:0001612)2.72250649
38Trismus (HP:0000211)2.71048240
39Abnormality of the calcaneus (HP:0008364)2.67173330
40Mesangial abnormality (HP:0001966)2.65878960
41Morphological abnormality of the middle ear (HP:0008609)2.61627872
42Chin dimple (HP:0010751)2.58304107
43Scapular winging (HP:0003691)2.57450611
44Turricephaly (HP:0000262)2.55981866
45Abnormality of skeletal muscle fiber size (HP:0012084)2.55572371
46Cystic hygroma (HP:0000476)2.54986948
47Wide anterior fontanel (HP:0000260)2.51452600
48Vitreoretinal degeneration (HP:0000655)2.50554352
49Abnormality of the calf musculature (HP:0001430)2.43548529
50Hypoplastic heart (HP:0001961)2.42728977
51Increased variability in muscle fiber diameter (HP:0003557)2.42658431
52Short 4th metacarpal (HP:0010044)2.40175892
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40175892
54Vertebral arch anomaly (HP:0008438)2.40143217
55Hyporeflexia of lower limbs (HP:0002600)2.39526381
56Distal lower limb amyotrophy (HP:0008944)2.39366810
57Cerebral aneurysm (HP:0004944)2.39304153
58Cutaneous syndactyly (HP:0012725)2.38369452
59Abnormality of the ischium (HP:0003174)2.38261915
60Limited hip movement (HP:0008800)2.36512132
61Ankle contracture (HP:0006466)2.36343910
62Arterial tortuosity (HP:0005116)2.34840657
63Mitral regurgitation (HP:0001653)2.34300719
64Abnormality of dentin (HP:0010299)2.34254715
65Abnormal finger flexion creases (HP:0006143)2.33871863
66Cutaneous finger syndactyly (HP:0010554)2.33553553
67Vascular tortuosity (HP:0004948)2.32129031
68Bowel diverticulosis (HP:0005222)2.31935120
69Aplasia involving bones of the extremities (HP:0009825)2.30984348
70Aplasia involving bones of the upper limbs (HP:0009823)2.30984348
71Aplasia of the phalanges of the hand (HP:0009802)2.30984348
72EMG: myopathic abnormalities (HP:0003458)2.30695661
73Focal segmental glomerulosclerosis (HP:0000097)2.29471555
74Increased density of long bones (HP:0006392)2.25079928
75Partial duplication of thumb phalanx (HP:0009944)2.23231590
76Genu recurvatum (HP:0002816)2.22224424
77Vertebral clefting (HP:0008428)2.21865360
78Mitral valve prolapse (HP:0001634)2.21329898
79Neonatal respiratory distress (HP:0002643)2.20878187
80Flexion contracture of toe (HP:0005830)2.19333409
81Joint contractures involving the joints of the feet (HP:0100492)2.19333409
82Broad long bones (HP:0005622)2.19306562
83Wrist flexion contracture (HP:0001239)2.19174372
84Broad thumb (HP:0011304)2.16762794
85Abnormality of the diencephalon (HP:0010662)2.16758711
86Absent septum pellucidum (HP:0001331)2.16734628
87Fused cervical vertebrae (HP:0002949)2.16674938
88Renovascular hypertension (HP:0100817)2.16453051
89Overriding aorta (HP:0002623)2.15078095
90Spinal rigidity (HP:0003306)2.13905770
91Vertebral fusion (HP:0002948)2.13072276
92Easy fatigability (HP:0003388)2.12941939
93Webbed neck (HP:0000465)2.11773928
94Trigonocephaly (HP:0000243)2.11700877
95Soft skin (HP:0000977)2.10894958
96Partial duplication of the phalanx of hand (HP:0009999)2.10885975
97Ulnar bowing (HP:0003031)2.10437058
98Coronal craniosynostosis (HP:0004440)2.07547922
99Myopathic facies (HP:0002058)2.06942044
100Generalized muscle weakness (HP:0003324)2.06652253
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04476584
102Rib fusion (HP:0000902)2.04407116
103Cortical dysplasia (HP:0002539)2.03528315
104Upper limb amyotrophy (HP:0009129)2.02872516
105Distal upper limb amyotrophy (HP:0007149)2.02872516
106Renal duplication (HP:0000075)2.02359053
107Elfin facies (HP:0004428)2.01708743
108Atrophic scars (HP:0001075)2.01346342
109Camptodactyly of toe (HP:0001836)1.99611577
110Lower limb amyotrophy (HP:0007210)1.97336596
111Exostoses (HP:0100777)1.96873736
112Knee flexion contracture (HP:0006380)1.96428631
113Breech presentation (HP:0001623)1.96113115
114Broad phalanx (HP:0006009)1.95732036
115Broad phalanges of the hand (HP:0009768)1.94637195
116Abnormality of the septum pellucidum (HP:0007375)1.94193133
117Lymphangioma (HP:0100764)1.93928546
118Insomnia (HP:0100785)1.93650738
119High anterior hairline (HP:0009890)1.92214415
120Broad finger (HP:0001500)1.90428449
121Arnold-Chiari malformation (HP:0002308)1.89910038
122Abnormality of the 4th metacarpal (HP:0010012)1.87809976
123Bulbar palsy (HP:0001283)1.86560904
124Tarsal synostosis (HP:0008368)1.85796818
125Hyperextensible skin (HP:0000974)1.83351224
126Hypoplastic ischia (HP:0003175)1.82345058
127Anophthalmia (HP:0000528)1.81369634
128Adducted thumb (HP:0001181)1.79038596
129Broad metatarsal (HP:0001783)1.77016649
130Bladder diverticulum (HP:0000015)1.76628141
131Hyperacusis (HP:0010780)1.76600010
132Maternal diabetes (HP:0009800)1.74141620
133Abnormalities of placenta or umbilical cord (HP:0001194)1.73099422
134Aortic aneurysm (HP:0004942)1.72754927
135Flat cornea (HP:0007720)1.72648491
136Infantile muscular hypotonia (HP:0008947)1.71870318
137Aortic dissection (HP:0002647)1.71807377
138Biconcave vertebral bodies (HP:0004586)1.70990153
139Pointed chin (HP:0000307)1.70816685
140Abnormality of the radial head (HP:0003995)1.70495410
141Limb-girdle muscle atrophy (HP:0003797)1.67877788
142Hypoventilation (HP:0002791)1.67634494
143Abnormality of the shoulder girdle musculature (HP:0001435)1.67143131
144Synostosis involving bones of the feet (HP:0009140)1.67093402
145Synostosis involving bones of the lower limbs (HP:0009138)1.67093402
146Abnormal albumin level (HP:0012116)1.65192856
147Hypoalbuminemia (HP:0003073)1.65192856
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63801605
149Absent epiphyses (HP:0010577)1.63801605
150Megalencephaly (HP:0001355)1.63530427
151Glomerulosclerosis (HP:0000096)1.62513884
152Aneurysm (HP:0002617)1.62011746
153Short palpebral fissure (HP:0012745)1.61817495
154Missing ribs (HP:0000921)1.61643031
155Sudden death (HP:0001699)1.61420704
156Long clavicles (HP:0000890)1.61221634
157Myelomeningocele (HP:0002475)1.60880206
158Omphalocele (HP:0001539)1.60662413
159Megalocornea (HP:0000485)1.59304126
160Spina bifida occulta (HP:0003298)1.58975690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.49456830
2MOS4.19127222
3EPHB23.88979035
4TTN3.51891606
5MARK13.36058299
6PAK42.91262229
7CDK122.90300412
8TNIK2.83209830
9MAP3K102.83184305
10NTRK22.55007950
11PKN22.42243657
12LATS12.26906057
13PDGFRA2.16624061
14CASK1.97424038
15PTK61.74534696
16SIK11.73834450
17TYRO31.69963937
18RIPK11.68789416
19DYRK1B1.68697887
20MKNK21.68216237
21FGFR21.61214566
22MUSK1.59621192
23LATS21.56365212
24CDK61.54765583
25ILK1.53793614
26PAK21.50396554
27DDR21.49784693
28PNCK1.48411134
29ICK1.45179717
30EPHA31.40426249
31WNK11.37360483
32BMX1.37177911
33EEF2K1.35551889
34LRRK21.33815184
35PTK21.29370423
36NEK11.26980257
37TGFBR21.25350303
38ROCK21.24921527
39DYRK21.23067053
40FER1.19817414
41KSR11.18064566
42BCR1.17736994
43FGFR11.17567759
44PAK61.13740461
45* MTOR1.13582861
46STK101.12745417
47ERBB21.11062352
48LIMK11.09564171
49TGFBR11.09011615
50ROCK11.07968155
51TIE11.07694401
52EPHA21.04999082
53DMPK1.03268029
54ERN11.02099062
55PIK3CG1.01005958
56CSNK1G20.98973346
57FGFR30.98346499
58PAK30.97652439
59MAP3K90.96411677
60AKT20.95051704
61MAP2K10.93796984
62PRKD30.93048198
63NTRK30.87695347
64EPHB10.84526890
65PDGFRB0.83873935
66ALK0.80946216
67NEK20.76992576
68UHMK10.74868973
69PIM20.74139480
70RPS6KA20.73344235
71PRKCH0.72510388
72TTK0.71068850
73* CDK140.70652018
74EPHA40.70579121
75NTRK10.69393198
76LMTK20.68749308
77ERBB40.66373440
78* CDK150.63571082
79SCYL20.62880614
80STK30.62198797
81ERBB30.60582956
82* CDK11A0.60274799
83KDR0.59437156
84RPS6KB20.59388943
85* CDK180.59342705
86PRKCG0.56837863
87NEK90.56604706
88MAPK100.56554366
89BUB10.56054290
90CDC70.54790781
91PLK20.54246951
92MKNK10.51940176
93CAMK2D0.51667064
94TESK20.50884327
95MAP3K80.50607710
96SIK20.49885370
97TAF10.48491256
98MAP3K40.48443896
99* CDK50.48382058
100PAK10.48147837
101MAP3K70.46898837
102PTK2B0.46809105
103OBSCN0.46568394
104PRKDC0.45955593
105TESK10.45796269
106CAMK1D0.44904551
107SMG10.44675507
108GSK3A0.44477134
109CAMK1G0.44401575
110SRC0.43690629
111AURKB0.43648742
112CSNK1G10.43595755
113SGK2230.42986665
114SGK4940.42986665
115CDK40.41654562
116MET0.41043872
117INSR0.40983200
118PRKG20.40364469
119KSR20.39839563
120CSNK1G30.38505546
121CHUK0.38029434
122CSNK1A1L0.37939093
123RET0.37858203
124CSNK1E0.37527076
125CDK80.37358832
126DYRK1A0.37221678
127AKT10.36633989
128MAP2K70.36054833
129* CDK10.35866812
130PRKD10.35172455
131MARK20.35161924
132CAMK2B0.33570953
133GSK3B0.33468486
134CAMK2A0.32866928
135CHEK10.32627758
136CAMK2G0.32517172
137CSF1R0.31750314
138CSNK1D0.31621776
139FGFR40.31569860
140STK38L0.31283158
141CHEK20.31263840
142BRD40.29426013
143TRPM70.27927251
144CDK70.27828109
145* MAPK90.27783719
146MELK0.27289501

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.03369678
2ECM-receptor interaction_Homo sapiens_hsa045122.96910780
3Dilated cardiomyopathy_Homo sapiens_hsa054142.74203960
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.72987745
5Focal adhesion_Homo sapiens_hsa045102.67230337
6Basal cell carcinoma_Homo sapiens_hsa052172.42370684
7Proteoglycans in cancer_Homo sapiens_hsa052052.34547313
8Bladder cancer_Homo sapiens_hsa052192.31462606
9Hippo signaling pathway_Homo sapiens_hsa043902.30315198
10Adherens junction_Homo sapiens_hsa045202.27322621
11Small cell lung cancer_Homo sapiens_hsa052222.22270805
12Viral myocarditis_Homo sapiens_hsa054162.20966867
13MicroRNAs in cancer_Homo sapiens_hsa052062.05245489
14Notch signaling pathway_Homo sapiens_hsa043302.00674761
15Hedgehog signaling pathway_Homo sapiens_hsa043401.98134453
16Tight junction_Homo sapiens_hsa045301.96022381
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.93693166
18Axon guidance_Homo sapiens_hsa043601.89173840
19Chronic myeloid leukemia_Homo sapiens_hsa052201.81910687
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66742532
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63786081
22Amoebiasis_Homo sapiens_hsa051461.53219921
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50360534
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.50135781
25Endometrial cancer_Homo sapiens_hsa052131.45947639
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.37165658
27Glioma_Homo sapiens_hsa052141.36312368
28Pancreatic cancer_Homo sapiens_hsa052121.33616307
29Dorso-ventral axis formation_Homo sapiens_hsa043201.31102801
30TGF-beta signaling pathway_Homo sapiens_hsa043501.27727210
31Colorectal cancer_Homo sapiens_hsa052101.26970265
32Wnt signaling pathway_Homo sapiens_hsa043101.25980234
33Pathways in cancer_Homo sapiens_hsa052001.22771314
34mTOR signaling pathway_Homo sapiens_hsa041501.22110138
35p53 signaling pathway_Homo sapiens_hsa041151.20065153
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17692471
37Renal cell carcinoma_Homo sapiens_hsa052111.15215724
38Cell cycle_Homo sapiens_hsa041101.14827193
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14285948
40Melanoma_Homo sapiens_hsa052181.11660286
41Prostate cancer_Homo sapiens_hsa052151.08548218
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08358987
43Non-small cell lung cancer_Homo sapiens_hsa052231.07251660
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.06670218
45Rap1 signaling pathway_Homo sapiens_hsa040151.06522026
46Circadian entrainment_Homo sapiens_hsa047131.04585253
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03262048
48HTLV-I infection_Homo sapiens_hsa051661.03037823
49Melanogenesis_Homo sapiens_hsa049161.02809138
50Cholinergic synapse_Homo sapiens_hsa047251.02580848
51Protein digestion and absorption_Homo sapiens_hsa049740.97892720
52Gap junction_Homo sapiens_hsa045400.95504558
53VEGF signaling pathway_Homo sapiens_hsa043700.92725479
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90338202
55Thyroid cancer_Homo sapiens_hsa052160.88417293
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88065762
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85770251
58Glutamatergic synapse_Homo sapiens_hsa047240.84926908
59Long-term potentiation_Homo sapiens_hsa047200.84166449
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83874764
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83648676
62cAMP signaling pathway_Homo sapiens_hsa040240.83473446
63Cocaine addiction_Homo sapiens_hsa050300.82478349
64AMPK signaling pathway_Homo sapiens_hsa041520.80524162
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.80319848
66Dopaminergic synapse_Homo sapiens_hsa047280.80100600
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79411676
68mRNA surveillance pathway_Homo sapiens_hsa030150.77291036
69Platelet activation_Homo sapiens_hsa046110.77149164
70Long-term depression_Homo sapiens_hsa047300.76880900
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76018639
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75073787
73Viral carcinogenesis_Homo sapiens_hsa052030.74329694
74Lysine degradation_Homo sapiens_hsa003100.74229179
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74010590
76HIF-1 signaling pathway_Homo sapiens_hsa040660.73762646
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73122270
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73083561
79ErbB signaling pathway_Homo sapiens_hsa040120.72110736
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71481988
81Estrogen signaling pathway_Homo sapiens_hsa049150.71251494
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70299205
83Insulin signaling pathway_Homo sapiens_hsa049100.69159846
84FoxO signaling pathway_Homo sapiens_hsa040680.69043832
85Oxytocin signaling pathway_Homo sapiens_hsa049210.67211273
86Shigellosis_Homo sapiens_hsa051310.66754160
87RNA transport_Homo sapiens_hsa030130.64969751
88Nicotine addiction_Homo sapiens_hsa050330.64662827
89Gastric acid secretion_Homo sapiens_hsa049710.64243261
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63496181
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62794999
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.62389771
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61448048
94Renin-angiotensin system_Homo sapiens_hsa046140.61082696
95Salmonella infection_Homo sapiens_hsa051320.59291398
96Prion diseases_Homo sapiens_hsa050200.58787315
97Toxoplasmosis_Homo sapiens_hsa051450.58518537
98MAPK signaling pathway_Homo sapiens_hsa040100.55708096
99Insulin secretion_Homo sapiens_hsa049110.54923099
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54665578
101Insulin resistance_Homo sapiens_hsa049310.53953465
102Endocytosis_Homo sapiens_hsa041440.53641600
103Spliceosome_Homo sapiens_hsa030400.53011291
104GABAergic synapse_Homo sapiens_hsa047270.52540598
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50025328
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.49511223
107Choline metabolism in cancer_Homo sapiens_hsa052310.49390160
108Renin secretion_Homo sapiens_hsa049240.49378481
109Acute myeloid leukemia_Homo sapiens_hsa052210.48477339
110Ras signaling pathway_Homo sapiens_hsa040140.48335365
111Oocyte meiosis_Homo sapiens_hsa041140.47767103
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47704139
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47599740
114Apoptosis_Homo sapiens_hsa042100.46553600
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46161523
116Hepatitis B_Homo sapiens_hsa051610.45229063
117Amphetamine addiction_Homo sapiens_hsa050310.44065280
118Glucagon signaling pathway_Homo sapiens_hsa049220.43800965
119GnRH signaling pathway_Homo sapiens_hsa049120.43598259
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43416193
121Biosynthesis of amino acids_Homo sapiens_hsa012300.42951115
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41823622
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41285936
124Morphine addiction_Homo sapiens_hsa050320.41281652
125Cardiac muscle contraction_Homo sapiens_hsa042600.36749193
126Prolactin signaling pathway_Homo sapiens_hsa049170.36538997

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