NEO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.01656102
2paraxial mesoderm development (GO:0048339)3.86722195
3axonal fasciculation (GO:0007413)3.41555017
4synaptic vesicle maturation (GO:0016188)3.38213977
5dendrite morphogenesis (GO:0048813)3.36705473
6establishment of nucleus localization (GO:0040023)3.26486097
7negative regulation of catenin import into nucleus (GO:0035414)3.22573422
8postsynaptic membrane organization (GO:0001941)3.20449737
9dendritic spine morphogenesis (GO:0060997)3.19663540
10locomotory exploration behavior (GO:0035641)3.13379288
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13177968
12apical protein localization (GO:0045176)3.05976885
13central nervous system projection neuron axonogenesis (GO:0021952)3.04560069
14cell migration in hindbrain (GO:0021535)3.04160071
15neuron recognition (GO:0008038)3.03639197
16lateral sprouting from an epithelium (GO:0060601)2.95396472
17cerebellar granule cell differentiation (GO:0021707)2.92992136
18convergent extension (GO:0060026)2.91573786
19establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.91545722
20bone trabecula formation (GO:0060346)2.91236569
21central nervous system myelination (GO:0022010)2.86539243
22axon ensheathment in central nervous system (GO:0032291)2.86539243
23gonadal mesoderm development (GO:0007506)2.86232848
24axon extension involved in axon guidance (GO:0048846)2.80546008
25neuron projection extension involved in neuron projection guidance (GO:1902284)2.80546008
26embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79744464
27neuron cell-cell adhesion (GO:0007158)2.79651598
28asymmetric protein localization (GO:0008105)2.76051914
29regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75482060
30cytoskeletal anchoring at plasma membrane (GO:0007016)2.74829149
31regulation of axon extension involved in axon guidance (GO:0048841)2.74144697
32proline transport (GO:0015824)2.72000001
33notochord development (GO:0030903)2.69872180
34polarized epithelial cell differentiation (GO:0030859)2.68697076
35axon extension (GO:0048675)2.67838582
36camera-type eye morphogenesis (GO:0048593)2.66687745
37myelination in peripheral nervous system (GO:0022011)2.60773219
38peripheral nervous system axon ensheathment (GO:0032292)2.60773219
39synaptic vesicle docking involved in exocytosis (GO:0016081)2.60761358
40establishment or maintenance of apical/basal cell polarity (GO:0035088)2.60265948
41establishment or maintenance of bipolar cell polarity (GO:0061245)2.60265948
42myelination (GO:0042552)2.58282062
43non-canonical Wnt signaling pathway (GO:0035567)2.58218569
44axon ensheathment (GO:0008366)2.56713409
45ensheathment of neurons (GO:0007272)2.56713409
46establishment of tissue polarity (GO:0007164)2.54794799
47establishment of planar polarity (GO:0001736)2.54794799
48regulation of axon guidance (GO:1902667)2.54462969
49exploration behavior (GO:0035640)2.52751933
50regulation of catenin import into nucleus (GO:0035412)2.51874958
51pyrimidine nucleobase catabolic process (GO:0006208)2.51426119
52head development (GO:0060322)2.49952396
53negative regulation of axon extension involved in axon guidance (GO:0048843)2.49900961
54establishment of mitochondrion localization (GO:0051654)2.49589510
55positive regulation of axon extension (GO:0045773)2.48734735
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45227296
57hippo signaling (GO:0035329)2.44770597
58regulation of NFAT protein import into nucleus (GO:0051532)2.43038371
59negative regulation of potassium ion transmembrane transport (GO:1901380)2.42593470
60central nervous system neuron axonogenesis (GO:0021955)2.42403246
61vocalization behavior (GO:0071625)2.41927909
62semaphorin-plexin signaling pathway (GO:0071526)2.41872078
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.41721048
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.40596591
65cerebral cortex radially oriented cell migration (GO:0021799)2.39891901
66neuromuscular junction development (GO:0007528)2.39810830
67nerve growth factor signaling pathway (GO:0038180)2.39734838
68cellular potassium ion homeostasis (GO:0030007)2.39624836
69limb bud formation (GO:0060174)2.38381793
70ovulation cycle (GO:0042698)2.36801314
71negative regulation of axon extension (GO:0030517)2.36240832
72innervation (GO:0060384)2.36032161
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35221511
74negative regulation of axonogenesis (GO:0050771)2.33361116
75glutamate secretion (GO:0014047)2.32907544
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.32409471
77neuron projection extension (GO:1990138)2.31241049
78body morphogenesis (GO:0010171)2.30118241
79chondrocyte development (GO:0002063)2.28480820
80cell communication by electrical coupling (GO:0010644)2.28461521
81embryonic foregut morphogenesis (GO:0048617)2.27223941
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.26696803
83myotube differentiation (GO:0014902)2.25373105
84cerebellar Purkinje cell layer development (GO:0021680)2.25107666
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.24614562
86mitochondrion transport along microtubule (GO:0047497)2.24614562
87lung-associated mesenchyme development (GO:0060484)2.24544765
88negative regulation of axon guidance (GO:1902668)2.23891697
89ephrin receptor signaling pathway (GO:0048013)2.23804656
90developmental cell growth (GO:0048588)2.23647449
91protein localization to synapse (GO:0035418)2.21812565
92positive regulation of neurological system process (GO:0031646)2.21412977
93regulation of cardioblast differentiation (GO:0051890)2.20006848
94synapse organization (GO:0050808)2.19948711
95neuronal ion channel clustering (GO:0045161)2.19814162
96neuron projection morphogenesis (GO:0048812)2.19600221
97regulation of dendritic spine morphogenesis (GO:0061001)2.19532929
98inner ear receptor cell development (GO:0060119)2.19080811
99regulation of axon extension (GO:0030516)2.18994872
100negative regulation of hormone biosynthetic process (GO:0032353)2.18505105
101nucleus localization (GO:0051647)2.18071218
102astrocyte development (GO:0014002)2.16651361
103cell communication involved in cardiac conduction (GO:0086065)2.16520720
104lens morphogenesis in camera-type eye (GO:0002089)2.16265815
105dendritic spine organization (GO:0097061)2.16140229
106gastrulation with mouth forming second (GO:0001702)2.15799638
107sodium ion export (GO:0071436)2.15657104
108regulation of neuron migration (GO:2001222)2.15430729
109positive regulation of catenin import into nucleus (GO:0035413)2.14691057
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.14454871
111regulation of synaptic vesicle exocytosis (GO:2000300)2.14202373
112regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.13858382
113membrane assembly (GO:0071709)2.13574040
114presynaptic membrane assembly (GO:0097105)2.12360250
115developmental growth involved in morphogenesis (GO:0060560)2.12082011
116cochlea morphogenesis (GO:0090103)2.11944716
117plasma membrane repair (GO:0001778)2.11400713
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11350255
119auditory behavior (GO:0031223)2.10806739
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.10146301
121glial cell proliferation (GO:0014009)2.09895300
122regulation of establishment of planar polarity (GO:0090175)2.09702324
123regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.09676329
124regulation of extent of cell growth (GO:0061387)2.09595304
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.09293707
126mating behavior (GO:0007617)2.09129016
127positive regulation of synapse maturation (GO:0090129)2.09106193
128morphogenesis of an epithelial sheet (GO:0002011)2.08812061
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.08766829
130prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.08748017
131organelle transport along microtubule (GO:0072384)2.08145766
132presynaptic membrane organization (GO:0097090)2.07585432
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.07392898
134dorsal/ventral axis specification (GO:0009950)2.07389120
135regulation of glutamate receptor signaling pathway (GO:1900449)2.07377279
136cerebral cortex development (GO:0021987)2.07167210
137regulation of neuronal synaptic plasticity (GO:0048168)2.07112321
138positive regulation of gastrulation (GO:2000543)2.06915024
139eye morphogenesis (GO:0048592)2.06867961
140spinal cord development (GO:0021510)2.06807410
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.06752939
142negative regulation of keratinocyte proliferation (GO:0010839)2.06564554
143cell-cell junction maintenance (GO:0045217)2.06137068
144branching involved in salivary gland morphogenesis (GO:0060445)2.05992393
145cranial nerve morphogenesis (GO:0021602)2.04414362
146embryonic camera-type eye morphogenesis (GO:0048596)2.03704813
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.03578243
148nucleobase catabolic process (GO:0046113)2.02786732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.33865966
2EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44454565
3RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44454565
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42301212
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37336255
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.34752156
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34704420
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34253126
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26892594
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21957032
11GBX2_23144817_ChIP-Seq_PC3_Human2.21567846
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11311548
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05795498
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.05401669
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.02489691
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02215254
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97674867
18* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97322478
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96109100
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84407552
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82908805
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.79800212
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78771899
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78528707
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.77639718
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75264400
27DROSHA_22980978_ChIP-Seq_HELA_Human1.75261206
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72308367
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65000725
30RING1B_27294783_Chip-Seq_NPCs_Mouse1.62056797
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57472426
32AR_21572438_ChIP-Seq_LNCaP_Human1.56666018
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53952769
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53765483
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51803806
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.48807319
37WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47782665
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.44672000
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.43318990
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43052072
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41554480
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41061818
43* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40964062
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40963237
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40457970
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.39770909
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38217762
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38217762
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38217762
50AHR_22903824_ChIP-Seq_MCF-7_Human1.37666506
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.35609136
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.35498634
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.35219844
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33303792
55* KDM2B_26808549_Chip-Seq_K562_Human1.32131067
56* ISL1_27105846_Chip-Seq_CPCs_Mouse1.31525545
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.30152430
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28493636
59* REST_21632747_ChIP-Seq_MESCs_Mouse1.25278673
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.24850599
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24036864
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23999790
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.21986160
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21981923
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.20992890
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20087461
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19544978
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19069136
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17840930
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17008110
71* AR_19668381_ChIP-Seq_PC3_Human1.15934704
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14244970
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12955638
74ZNF274_21170338_ChIP-Seq_K562_Hela1.12026100
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11572100
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11426739
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11325829
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11174133
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.10164898
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08412322
81SMAD4_21799915_ChIP-Seq_A2780_Human1.07791185
82RNF2_27304074_Chip-Seq_NSC_Mouse1.06979734
83* STAT3_23295773_ChIP-Seq_U87_Human1.06252259
84* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05364720
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04991357
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.04939193
87* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02724424
88* SMAD3_21741376_ChIP-Seq_EPCs_Human1.02723974
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02553825
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01545759
91* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01144993
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01036467
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00884959
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00466253
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00204634
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00005302
97* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99788876
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.99637196
99TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99605420
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99096145
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98700771
102TCF4_18268006_ChIP-ChIP_LS174T_Human0.98670584
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98615886
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97419777
105CLOCK_20551151_ChIP-Seq_293T_Human0.96931223
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.96850202
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96405973
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95848105
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.94611750
110ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93910444
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93769646
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93769646
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93767621
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93693005
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93120218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.52654380
2MP0004859_abnormal_synaptic_plasticity2.70049737
3MP0004270_analgesia2.39831390
4MP0009780_abnormal_chondrocyte_physiolo2.25469683
5MP0003122_maternal_imprinting2.19688845
6MP0005623_abnormal_meninges_morphology2.18813567
7MP0000778_abnormal_nervous_system2.18146622
8MP0003283_abnormal_digestive_organ2.03993189
9MP0001299_abnormal_eye_distance/1.95815837
10MP0004858_abnormal_nervous_system1.94729739
11MP0000537_abnormal_urethra_morphology1.94083678
12MP0004885_abnormal_endolymph1.93174023
13MP0005503_abnormal_tendon_morphology1.76409525
14MP0010030_abnormal_orbit_morphology1.72736498
15MP0003705_abnormal_hypodermis_morpholog1.68051473
16MP0008438_abnormal_cutaneous_collagen1.68041972
17MP0003635_abnormal_synaptic_transmissio1.66953369
18MP0005187_abnormal_penis_morphology1.65266704
19MP0005409_darkened_coat_color1.65263102
20MP0009250_abnormal_appendicular_skeleto1.60162752
21MP0003385_abnormal_body_wall1.55672888
22MP0004272_abnormal_basement_membrane1.52024067
23MP0003937_abnormal_limbs/digits/tail_de1.49827430
24MP0000534_abnormal_ureter_morphology1.48795223
25MP0000428_abnormal_craniofacial_morphol1.46473389
26MP0009384_cardiac_valve_regurgitation1.44847184
27MP0003755_abnormal_palate_morphology1.40264326
28MP0002697_abnormal_eye_size1.39453618
29MP0003942_abnormal_urinary_system1.39130356
30MP0002063_abnormal_learning/memory/cond1.38642615
31MP0003121_genomic_imprinting1.36221425
32MP0005248_abnormal_Harderian_gland1.35862956
33MP0000955_abnormal_spinal_cord1.32727188
34MP0003941_abnormal_skin_development1.31652238
35MP0000751_myopathy1.30562467
36MP0000462_abnormal_digestive_system1.30379328
37MP0001486_abnormal_startle_reflex1.29992660
38MP0003890_abnormal_embryonic-extraembry1.29661384
39MP0003935_abnormal_craniofacial_develop1.29481411
40MP0003880_abnormal_central_pattern1.29475693
41MP0000049_abnormal_middle_ear1.29120217
42MP0002233_abnormal_nose_morphology1.28204900
43MP0005423_abnormal_somatic_nervous1.26906982
44MP0003119_abnormal_digestive_system1.26639296
45MP0002184_abnormal_innervation1.22948061
46MP0002734_abnormal_mechanical_nocicepti1.21270219
47MP0002116_abnormal_craniofacial_bone1.21155855
48MP0000762_abnormal_tongue_morphology1.19758793
49MP0010234_abnormal_vibrissa_follicle1.19595977
50MP0002234_abnormal_pharynx_morphology1.19346474
51MP0000631_abnormal_neuroendocrine_gland1.18116181
52MP0002932_abnormal_joint_morphology1.17664266
53MP0004134_abnormal_chest_morphology1.16314441
54MP0003861_abnormal_nervous_system1.15816528
55MP0002108_abnormal_muscle_morphology1.14452500
56MP0010678_abnormal_skin_adnexa1.13579274
57MP0003938_abnormal_ear_development1.13216899
58MP0003137_abnormal_impulse_conducting1.11636171
59MP0003787_abnormal_imprinting1.11312790
60MP0005275_abnormal_skin_tensile1.10627858
61MP0005257_abnormal_intraocular_pressure1.10529736
62MP0002572_abnormal_emotion/affect_behav1.10426527
63MP0002896_abnormal_bone_mineralization1.09270766
64MP0001346_abnormal_lacrimal_gland1.09069293
65MP0009053_abnormal_anal_canal1.08921542
66MP0002882_abnormal_neuron_morphology1.08772097
67MP0002822_catalepsy1.06547730
68MP0002089_abnormal_postnatal_growth/wei1.06458379
69MP0001984_abnormal_olfaction1.05645132
70MP0003634_abnormal_glial_cell1.05132393
71MP0003329_amyloid_beta_deposits1.04762767
72MP0005508_abnormal_skeleton_morphology1.03214376
73MP0004145_abnormal_muscle_electrophysio1.02976037
74MP0000733_abnormal_muscle_development1.02609609
75MP0009672_abnormal_birth_weight1.02377997
76MP0002064_seizures1.02020658
77MP0002152_abnormal_brain_morphology1.01692151
78MP0000432_abnormal_head_morphology0.99821095
79MP0001177_atelectasis0.99451823
80MP0001188_hyperpigmentation0.99375070
81MP0000569_abnormal_digit_pigmentation0.99264365
82MP0000647_abnormal_sebaceous_gland0.98920633
83MP0000383_abnormal_hair_follicle0.97329413
84MP0000920_abnormal_myelination0.95778510
85MP0009745_abnormal_behavioral_response0.95065412
86MP0003115_abnormal_respiratory_system0.94876721
87MP0002249_abnormal_larynx_morphology0.94784717
88MP0002938_white_spotting0.94149126
89MP0004233_abnormal_muscle_weight0.94020429
90MP0003123_paternal_imprinting0.93983547
91MP0005499_abnormal_olfactory_system0.92897679
92MP0005394_taste/olfaction_phenotype0.92897679
93MP0001849_ear_inflammation0.92718135
94MP0002735_abnormal_chemical_nociception0.92271325
95MP0001348_abnormal_lacrimal_gland0.91009374
96MP0001440_abnormal_grooming_behavior0.90332647
97MP0009046_muscle_twitch0.90115599
98MP0004811_abnormal_neuron_physiology0.89722394
99MP0001293_anophthalmia0.89518152
100MP0002084_abnormal_developmental_patter0.89112829
101MP0002114_abnormal_axial_skeleton0.88324706
102MP0001502_abnormal_circadian_rhythm0.88295061
103MP0005171_absent_coat_pigmentation0.88294177
104MP0002653_abnormal_ependyma_morphology0.87746723
105MP0002909_abnormal_adrenal_gland0.86975025
106MP0005076_abnormal_cell_differentiation0.86522379
107MP0002557_abnormal_social/conspecific_i0.85465944
108MP0000163_abnormal_cartilage_morphology0.85449792
109MP0001286_abnormal_eye_development0.85408947
110MP0000579_abnormal_nail_morphology0.85144705
111MP0009703_decreased_birth_body0.84877979
112MP0002111_abnormal_tail_morphology0.84591267
113MP0001958_emphysema0.84509934
114MP0003136_yellow_coat_color0.84039448
115MP0002272_abnormal_nervous_system0.83664768
116MP0002733_abnormal_thermal_nociception0.82838591
117MP0002092_abnormal_eye_morphology0.82472998
118MP0000026_abnormal_inner_ear0.81539876
119* MP0002081_perinatal_lethality0.80415533
120MP0002085_abnormal_embryonic_tissue0.79180265
121MP0003632_abnormal_nervous_system0.78913041
122MP0004043_abnormal_pH_regulation0.78445614
123MP0002751_abnormal_autonomic_nervous0.78316981
124MP0004084_abnormal_cardiac_muscle0.78045148
125MP0009379_abnormal_foot_pigmentation0.76959003

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)3.27335747
2Shallow orbits (HP:0000586)3.09352807
3Abnormality of the corticospinal tract (HP:0002492)2.94943952
4Short 4th metacarpal (HP:0010044)2.83199563
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83199563
6Macroorchidism (HP:0000053)2.56572434
7Partial duplication of thumb phalanx (HP:0009944)2.46387082
8Bilateral microphthalmos (HP:0007633)2.42595321
9Abnormality of the 4th metacarpal (HP:0010012)2.40650525
10Coronal craniosynostosis (HP:0004440)2.39770200
11Renal duplication (HP:0000075)2.36584579
12Neoplasm of the heart (HP:0100544)2.33739339
13Termporal pattern (HP:0011008)2.31953827
14Insidious onset (HP:0003587)2.31953827
15Broad metatarsal (HP:0001783)2.27957542
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.27374770
17Partial duplication of the phalanx of hand (HP:0009999)2.20387280
18Protrusio acetabuli (HP:0003179)2.19824451
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17106998
20Degeneration of the lateral corticospinal tracts (HP:0002314)2.17106998
21Buphthalmos (HP:0000557)2.15474260
22Aplasia involving bones of the extremities (HP:0009825)2.13907876
23Aplasia involving bones of the upper limbs (HP:0009823)2.13907876
24Aplasia of the phalanges of the hand (HP:0009802)2.13907876
25Megalencephaly (HP:0001355)2.13339185
26Astrocytoma (HP:0009592)2.11053906
27Abnormality of the astrocytes (HP:0100707)2.11053906
28Abnormality of the lower motor neuron (HP:0002366)2.10224913
29Cerebral inclusion bodies (HP:0100314)2.08910202
30Premature rupture of membranes (HP:0001788)2.06111217
31Neurofibrillary tangles (HP:0002185)2.05662714
32Bladder diverticulum (HP:0000015)2.03586438
33Arterial tortuosity (HP:0005116)2.02820921
34Ankle clonus (HP:0011448)2.01130202
35Lymphangioma (HP:0100764)2.01036523
36Vascular tortuosity (HP:0004948)2.00036916
37Amyotrophic lateral sclerosis (HP:0007354)1.99322117
38Hypoplastic ischia (HP:0003175)1.96417481
39Bronchomalacia (HP:0002780)1.94603267
40Overriding aorta (HP:0002623)1.93194732
41High anterior hairline (HP:0009890)1.93160516
42Relative macrocephaly (HP:0004482)1.92859511
43Turricephaly (HP:0000262)1.90724584
44Excessive salivation (HP:0003781)1.90299779
45Drooling (HP:0002307)1.90299779
46Difficulty running (HP:0009046)1.90085426
47Abnormality of the pubic bones (HP:0003172)1.89652438
48Vitreoretinal degeneration (HP:0000655)1.89425414
49Ankle contracture (HP:0006466)1.85805913
50Cutaneous finger syndactyly (HP:0010554)1.85672724
51Wide anterior fontanel (HP:0000260)1.85258627
52Vertebral arch anomaly (HP:0008438)1.83178236
53Overgrowth (HP:0001548)1.80609602
54Abnormality of the distal phalanx of the thumb (HP:0009617)1.77537906
55Sensory axonal neuropathy (HP:0003390)1.76343337
56Obstructive sleep apnea (HP:0002870)1.75770841
57Arnold-Chiari malformation (HP:0002308)1.75413679
58Neonatal short-limb short stature (HP:0008921)1.74595258
59Tracheomalacia (HP:0002779)1.73800913
60Deviation of the hallux (HP:0010051)1.73561636
61Alacrima (HP:0000522)1.72766487
62Abnormality of the phalanges of the hallux (HP:0010057)1.71923490
63Ankyloglossia (HP:0010296)1.71272182
64Choanal stenosis (HP:0000452)1.70956612
65Thin ribs (HP:0000883)1.70869057
66Abnormality of the aortic arch (HP:0012303)1.70500089
67Shawl scrotum (HP:0000049)1.70122409
68Focal seizures (HP:0007359)1.70052599
69Increased variability in muscle fiber diameter (HP:0003557)1.69916396
70Infantile muscular hypotonia (HP:0008947)1.68410955
71Morphological abnormality of the middle ear (HP:0008609)1.68329174
72Limited hip movement (HP:0008800)1.68267357
73Abnormality of the ischium (HP:0003174)1.67638702
74Hallux valgus (HP:0001822)1.67567197
75Insomnia (HP:0100785)1.67307277
76Action tremor (HP:0002345)1.66774649
77Supranuclear gaze palsy (HP:0000605)1.66671811
78Anteriorly placed anus (HP:0001545)1.65761809
79Myokymia (HP:0002411)1.64592233
80Midline defect of the nose (HP:0004122)1.64252973
81Preaxial foot polydactyly (HP:0001841)1.62982581
82Bell-shaped thorax (HP:0001591)1.62362480
83Broad thumb (HP:0011304)1.62204754
84Ulnar bowing (HP:0003031)1.61439931
85Broad long bones (HP:0005622)1.61334504
86Epileptic encephalopathy (HP:0200134)1.61105901
87Hyperextensible skin (HP:0000974)1.61061113
88Spastic gait (HP:0002064)1.59749997
89Aqueductal stenosis (HP:0002410)1.59110932
90Papillary thyroid carcinoma (HP:0002895)1.58232849
91Scapular winging (HP:0003691)1.57495526
92Flat cornea (HP:0007720)1.57135638
93Mildly elevated creatine phosphokinase (HP:0008180)1.56366218
94Glioma (HP:0009733)1.56065760
95Open mouth (HP:0000194)1.56064715
96Omphalocele (HP:0001539)1.55781623
97Cutaneous syndactyly (HP:0012725)1.55231337
98Abnormality of the diencephalon (HP:0010662)1.55123970
99Upper limb amyotrophy (HP:0009129)1.55104212
100Distal upper limb amyotrophy (HP:0007149)1.55104212
101Broad finger (HP:0001500)1.54895619
102Aortic dissection (HP:0002647)1.54317791
103Intention tremor (HP:0002080)1.52180897
104Lower limb muscle weakness (HP:0007340)1.51836980
105Genetic anticipation (HP:0003743)1.51709319
106Large earlobe (HP:0009748)1.51244150
107Hemiparesis (HP:0001269)1.50901391
108Broad phalanx (HP:0006009)1.50627932
109Elfin facies (HP:0004428)1.50522187
110Abnormality of the middle phalanges of the toes (HP:0010183)1.50459960
111Bifid tongue (HP:0010297)1.50446728
112Hyperacusis (HP:0010780)1.50046813
113Atrophic scars (HP:0001075)1.49985595
114Abnormality of molar morphology (HP:0011070)1.49750577
115Abnormality of molar (HP:0011077)1.49750577
116Broad phalanges of the hand (HP:0009768)1.49532350
117Increased nuchal translucency (HP:0010880)1.49373750
118Split foot (HP:0001839)1.49332795
119Broad ribs (HP:0000885)1.49042385
120Hypoplastic labia majora (HP:0000059)1.48485422
121Abnormality of permanent molar morphology (HP:0011071)1.48437900
122Abnormality of the dental root (HP:0006486)1.48437900
123Taurodontia (HP:0000679)1.48437900
124Renovascular hypertension (HP:0100817)1.47659189
125Abnormality of dentin (HP:0010299)1.47369488
126Myelomeningocele (HP:0002475)1.47115069
127Bowel diverticulosis (HP:0005222)1.46922663
128Asymmetry of the thorax (HP:0001555)1.46360161
129Laryngomalacia (HP:0001601)1.46052531
130Aortic aneurysm (HP:0004942)1.45907823
131Bifid scrotum (HP:0000048)1.45646680
132Bicornuate uterus (HP:0000813)1.45046733
133Broad palm (HP:0001169)1.44899294
134Right ventricular cardiomyopathy (HP:0011663)1.44648217
135Mixed hearing impairment (HP:0000410)1.44355258
136Duplication of thumb phalanx (HP:0009942)1.44263027
137Mitral valve prolapse (HP:0001634)1.43812167
138Hypoventilation (HP:0002791)1.43037423
139Trigonocephaly (HP:0000243)1.42783650
140Septo-optic dysplasia (HP:0100842)1.42636114
141Heterotopia (HP:0002282)1.42229600
142Hyporeflexia of lower limbs (HP:0002600)1.41806415
143Subacute progressive viral hepatitis (HP:0006572)1.41482622
144Sacral dimple (HP:0000960)1.41351015
145Genu recurvatum (HP:0002816)1.41140004
146Hemangiomatosis (HP:0007461)1.41009663
147Visceral angiomatosis (HP:0100761)1.40781651
148Focal motor seizures (HP:0011153)1.40599111
149Urethral obstruction (HP:0000796)1.40196209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.96790200
2CDK122.81482763
3TYRO32.60068361
4DDR22.36932472
5LATS12.05749387
6EEF2K1.96906950
7MAP3K91.96233308
8NTRK11.93857124
9PAK61.92208191
10MAP3K101.89252295
11ICK1.88844967
12LATS21.88499632
13PDGFRA1.85659742
14FGFR21.82013302
15PHKG11.81732392
16PHKG21.81732392
17NTRK31.79899812
18STK391.72828668
19PRKD31.63660168
20WNK11.62824666
21PAK31.61367186
22MAP3K41.53895635
23NTRK21.53340835
24EPHA41.49154644
25EPHB21.35939635
26GRK51.33571045
27KSR11.30757329
28BCR1.29401438
29TRIB31.29393270
30CAMK1G1.28114335
31UHMK11.26064347
32RIPK11.25816533
33MINK11.25288958
34MET1.24645863
35DYRK21.24549840
36MAP3K21.21809451
37BRD41.19596101
38DMPK1.17186577
39LMTK21.15861086
40CSNK1A1L1.13387947
41MARK21.08431971
42WNK41.04491490
43CSNK1G21.04311004
44SGK21.04230640
45KSR21.03754067
46WNK31.03631828
47AKT31.02088900
48PTK21.01064907
49MAPK130.99857877
50OXSR10.98894497
51TTN0.97871713
52CDK50.92104406
53ERBB30.91987662
54PDGFRB0.90818237
55LIMK10.89565212
56MAP2K40.89027848
57RET0.88839903
58FGFR10.88752285
59CAMK1D0.88459003
60SGK30.88305366
61STK38L0.88195891
62SIK10.83414660
63FER0.83029675
64PKN10.83004757
65CSNK1G30.82985788
66MTOR0.80853365
67FGFR30.76976379
68CDK140.76437613
69FGFR40.76350867
70ERBB20.76325819
71CDC42BPA0.76077550
72DAPK20.75652549
73CSNK1G10.74106252
74PAK20.73202830
75BMX0.73189383
76CDK150.72291830
77ROCK20.71996837
78EPHA20.70790956
79ROCK10.70712827
80TNIK0.70539026
81CDK180.70194150
82OBSCN0.70065989
83PNCK0.68625656
84DYRK1A0.66383728
85PIK3CA0.65343872
86PLK20.65108608
87ALK0.64043864
88CAMKK10.64014271
89EPHB10.63712925
90PRPF4B0.62832522
91RPS6KA20.62467746
92PRKCH0.60904428
93CDK11A0.59400092
94SGK4940.59035891
95SGK2230.59035891
96EPHA30.58876057
97STK110.58715800
98PKN20.54979296
99NEK60.53895184
100CAMK2A0.52718993
101MKNK20.52408956
102STK380.52128449
103ADRBK10.51064166
104MAPK70.51015064
105PRKD10.50592049
106CAMK40.50289076
107PRKCZ0.49660931
108MAPK100.48237387
109CSNK1D0.47976659
110TAOK10.47731814
111PTK60.47141812
112DYRK1B0.46049214
113CSNK1E0.44886902
114TRIM280.43820340
115PRKCG0.43728461
116GSK3B0.43721517
117PRKAA10.43529488
118FGR0.43460438
119MAP3K70.43286951
120SGK10.42602497
121MAPK150.42465847
122CASK0.42203659
123STK30.42140209
124CAMK2B0.42094242
125RPS6KB10.42082317
126CAMK2G0.41462194
127PRKDC0.39311435

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.36668930
2Basal cell carcinoma_Homo sapiens_hsa052171.91677844
3Hedgehog signaling pathway_Homo sapiens_hsa043401.91171891
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68837316
5Glutamatergic synapse_Homo sapiens_hsa047241.68406912
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67501581
7GABAergic synapse_Homo sapiens_hsa047271.63124879
8Circadian entrainment_Homo sapiens_hsa047131.61606391
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60859303
10Hippo signaling pathway_Homo sapiens_hsa043901.56892196
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50711449
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50130655
13Dopaminergic synapse_Homo sapiens_hsa047281.48587770
14Long-term potentiation_Homo sapiens_hsa047201.45799410
15ECM-receptor interaction_Homo sapiens_hsa045121.43463159
16Dilated cardiomyopathy_Homo sapiens_hsa054141.41440801
17Gap junction_Homo sapiens_hsa045401.40830064
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40151245
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39946763
20Nicotine addiction_Homo sapiens_hsa050331.37877758
21Tight junction_Homo sapiens_hsa045301.36852474
22Dorso-ventral axis formation_Homo sapiens_hsa043201.36079871
23Long-term depression_Homo sapiens_hsa047301.35863536
24Wnt signaling pathway_Homo sapiens_hsa043101.32602145
25Melanogenesis_Homo sapiens_hsa049161.32171300
26GnRH signaling pathway_Homo sapiens_hsa049121.31338582
27Renin secretion_Homo sapiens_hsa049241.29696232
28Gastric acid secretion_Homo sapiens_hsa049711.29549978
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29268836
30Focal adhesion_Homo sapiens_hsa045101.28565388
31Cocaine addiction_Homo sapiens_hsa050301.27304615
32Cholinergic synapse_Homo sapiens_hsa047251.26671239
33Salivary secretion_Homo sapiens_hsa049701.26606489
34Insulin secretion_Homo sapiens_hsa049111.26215233
35Amphetamine addiction_Homo sapiens_hsa050311.22773600
36Renal cell carcinoma_Homo sapiens_hsa052111.22397233
37ErbB signaling pathway_Homo sapiens_hsa040121.21074393
38Oxytocin signaling pathway_Homo sapiens_hsa049211.19098380
39Ovarian steroidogenesis_Homo sapiens_hsa049131.18747960
40Glioma_Homo sapiens_hsa052141.17141615
41Morphine addiction_Homo sapiens_hsa050321.16977794
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16378269
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16112838
44Serotonergic synapse_Homo sapiens_hsa047261.16084533
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12624431
46Proteoglycans in cancer_Homo sapiens_hsa052051.12460529
47Estrogen signaling pathway_Homo sapiens_hsa049151.12436733
48Bile secretion_Homo sapiens_hsa049761.12203578
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.11861948
50Adherens junction_Homo sapiens_hsa045201.11840957
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10901081
52Notch signaling pathway_Homo sapiens_hsa043301.10804491
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10648338
54cAMP signaling pathway_Homo sapiens_hsa040241.09426670
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09110363
56Type II diabetes mellitus_Homo sapiens_hsa049301.08983228
57Endometrial cancer_Homo sapiens_hsa052131.08568332
58Synaptic vesicle cycle_Homo sapiens_hsa047211.06115978
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05773009
60Protein digestion and absorption_Homo sapiens_hsa049741.05407322
61mTOR signaling pathway_Homo sapiens_hsa041501.03843433
62Olfactory transduction_Homo sapiens_hsa047401.02995715
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.00678130
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00064202
65Choline metabolism in cancer_Homo sapiens_hsa052310.95839365
66Lysine degradation_Homo sapiens_hsa003100.94148080
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92466410
68TGF-beta signaling pathway_Homo sapiens_hsa043500.91584018
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90402932
70Colorectal cancer_Homo sapiens_hsa052100.89489209
71Taste transduction_Homo sapiens_hsa047420.88004517
72Rap1 signaling pathway_Homo sapiens_hsa040150.87778753
73Thyroid cancer_Homo sapiens_hsa052160.86924477
74Glucagon signaling pathway_Homo sapiens_hsa049220.86150002
75* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85619844
76Ras signaling pathway_Homo sapiens_hsa040140.84339333
77MicroRNAs in cancer_Homo sapiens_hsa052060.83328237
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83031132
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81085273
80Circadian rhythm_Homo sapiens_hsa047100.80724374
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80486356
82Calcium signaling pathway_Homo sapiens_hsa040200.79155069
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79137496
84Insulin signaling pathway_Homo sapiens_hsa049100.78649687
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76731174
86VEGF signaling pathway_Homo sapiens_hsa043700.74576376
87Fatty acid biosynthesis_Homo sapiens_hsa000610.73926614
88Steroid biosynthesis_Homo sapiens_hsa001000.73748384
89AMPK signaling pathway_Homo sapiens_hsa041520.73712549
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73392909
91Oocyte meiosis_Homo sapiens_hsa041140.72201939
92Histidine metabolism_Homo sapiens_hsa003400.71812935
93Ether lipid metabolism_Homo sapiens_hsa005650.71398081
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.71384312
95Thyroid hormone synthesis_Homo sapiens_hsa049180.71326607
96Arginine and proline metabolism_Homo sapiens_hsa003300.70991908
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.70680713
98Vitamin B6 metabolism_Homo sapiens_hsa007500.70488696
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.70227509
100MAPK signaling pathway_Homo sapiens_hsa040100.69664551
101Nitrogen metabolism_Homo sapiens_hsa009100.69194217
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.68615440
103Pathways in cancer_Homo sapiens_hsa052000.67815185
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67410534
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66237671
106Inositol phosphate metabolism_Homo sapiens_hsa005620.65756128
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65636077
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62672311
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.62541948
110Amoebiasis_Homo sapiens_hsa051460.62310142
111Melanoma_Homo sapiens_hsa052180.62090245
112Endocytosis_Homo sapiens_hsa041440.61628510
113Bladder cancer_Homo sapiens_hsa052190.61443731
114Prion diseases_Homo sapiens_hsa050200.60201683
115Cardiac muscle contraction_Homo sapiens_hsa042600.60150784
116Pancreatic secretion_Homo sapiens_hsa049720.58495248
117Arginine biosynthesis_Homo sapiens_hsa002200.57031061
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56662312
119Prostate cancer_Homo sapiens_hsa052150.56413018
120Non-small cell lung cancer_Homo sapiens_hsa052230.56106094

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