NENF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.41994349
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.11352304
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08699293
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.03136684
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.99178992
6ATP synthesis coupled proton transport (GO:0015986)4.99178992
7respiratory electron transport chain (GO:0022904)4.46623562
8protein retention in ER lumen (GO:0006621)4.44266161
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.38205526
10electron transport chain (GO:0022900)4.37073725
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.35871489
12translational elongation (GO:0006414)4.33140095
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.31918912
14viral life cycle (GO:0019058)4.07522710
15nucleotide salvage (GO:0043173)4.01300687
16Golgi transport vesicle coating (GO:0048200)3.95461345
17COPI coating of Golgi vesicle (GO:0048205)3.95461345
18protein maturation by protein folding (GO:0022417)3.93935179
19deoxyribose phosphate biosynthetic process (GO:0046385)3.91663088
202-deoxyribonucleotide biosynthetic process (GO:0009265)3.91663088
21purine nucleotide salvage (GO:0032261)3.90506937
22ribosomal small subunit assembly (GO:0000028)3.85421140
23cellular protein complex disassembly (GO:0043624)3.71687959
24nucleobase-containing small molecule interconversion (GO:0015949)3.71516874
25maturation of SSU-rRNA (GO:0030490)3.68697905
26negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.64651809
27negative regulation of erythrocyte differentiation (GO:0045647)3.57995285
28response to thyroid hormone (GO:0097066)3.57499006
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55337590
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51789817
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46784399
32positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.38971733
33cellular response to thyroid hormone stimulus (GO:0097067)3.38595913
34pyrimidine nucleotide catabolic process (GO:0006244)3.32318178
35oligosaccharide catabolic process (GO:0009313)3.28992639
36negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.28963018
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27202526
38GTP biosynthetic process (GO:0006183)3.26716474
39deoxyribonucleotide catabolic process (GO:0009264)3.24216999
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19527190
41L-phenylalanine metabolic process (GO:0006558)3.19527190
42cellular response to arsenic-containing substance (GO:0071243)3.16729567
43glycosphingolipid catabolic process (GO:0046479)3.15574755
44mature B cell differentiation involved in immune response (GO:0002313)3.14977263
45regulation of oxidative phosphorylation (GO:0002082)3.14308903
46guanosine-containing compound biosynthetic process (GO:1901070)3.12228726
47chaperone-mediated protein transport (GO:0072321)3.11055349
48deoxyribose phosphate catabolic process (GO:0046386)3.11014191
49protein targeting to mitochondrion (GO:0006626)3.08950781
50protein complex disassembly (GO:0043241)3.08928459
51translational initiation (GO:0006413)3.07427199
52UTP biosynthetic process (GO:0006228)3.07202061
53mitochondrial calcium ion transport (GO:0006851)3.06598277
54growth hormone secretion (GO:0030252)3.06316206
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05742664
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.05736305
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03961540
58pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01461996
59GDP-mannose metabolic process (GO:0019673)2.97052050
60ribosomal large subunit biogenesis (GO:0042273)2.96954433
61pentose metabolic process (GO:0019321)2.96728982
62plasma membrane repair (GO:0001778)2.96563675
63UTP metabolic process (GO:0046051)2.92919559
64detection of calcium ion (GO:0005513)2.92458804
65CTP biosynthetic process (GO:0006241)2.90479215
66CTP metabolic process (GO:0046036)2.90479215
67toxin metabolic process (GO:0009404)2.88820315
68ribonucleoprotein complex biogenesis (GO:0022613)2.88556422
69pyrimidine nucleoside salvage (GO:0043097)2.87243486
70pyrimidine-containing compound salvage (GO:0008655)2.87243486
71pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.86827043
72glycolipid catabolic process (GO:0019377)2.86543566
73establishment of protein localization to mitochondrion (GO:0072655)2.86046240
74sarcomere organization (GO:0045214)2.84513525
75adenosine receptor signaling pathway (GO:0001973)2.83501042
76regulation of type B pancreatic cell apoptotic process (GO:2000674)2.81308601
77nucleoside salvage (GO:0043174)2.80764026
78translation (GO:0006412)2.79883511
79macromolecular complex disassembly (GO:0032984)2.79616918
80pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78398654
81hydrogen ion transmembrane transport (GO:1902600)2.76312519
82cellular component biogenesis (GO:0044085)2.75801729
83adhesion of symbiont to host cell (GO:0044650)2.75492423
84virion attachment to host cell (GO:0019062)2.75492423
85pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75396821
86ATP biosynthetic process (GO:0006754)2.73646654
87negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.73509227
88negative regulation of calcium ion transmembrane transport (GO:1903170)2.73509227
89cytochrome complex assembly (GO:0017004)2.72200156
902-deoxyribonucleotide metabolic process (GO:0009394)2.72001614
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.71310066
92NADH dehydrogenase complex assembly (GO:0010257)2.71310066
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71310066
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70610117
95pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.69390674
96positive regulation of vesicle fusion (GO:0031340)2.68903168
97nuclear envelope reassembly (GO:0031468)2.68379315
98mitotic nuclear envelope reassembly (GO:0007084)2.68379315
99cyclooxygenase pathway (GO:0019371)2.66650717
100UV protection (GO:0009650)2.66562421
101regulation of cell communication by electrical coupling (GO:0010649)2.66152364
102mitochondrial fusion (GO:0008053)2.65670044
103lipoxygenase pathway (GO:0019372)2.63927499
104prostaglandin biosynthetic process (GO:0001516)2.63731041
105prostanoid biosynthetic process (GO:0046457)2.63731041
106adhesion of symbiont to host (GO:0044406)2.63548860
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63210024
108negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62471280
109protein targeting to ER (GO:0045047)2.61963390
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60689567
111deoxyribose phosphate metabolic process (GO:0019692)2.60008103
112inner mitochondrial membrane organization (GO:0007007)2.59834423
113L-phenylalanine catabolic process (GO:0006559)2.59393084
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.59393084
115cotranslational protein targeting to membrane (GO:0006613)2.58420089
116protein complex biogenesis (GO:0070271)2.56886645
117activation of protein kinase A activity (GO:0034199)2.56590973
118ATP hydrolysis coupled proton transport (GO:0015991)2.56515427
119energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56515427
120positive regulation of insulin secretion (GO:0032024)2.56447720
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53849069
122signal peptide processing (GO:0006465)2.52146659
123purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50718212
124peptidyl-proline hydroxylation (GO:0019511)2.49856722
125regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48503117
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48312676
127protein localization to endoplasmic reticulum (GO:0070972)2.47122807
128regulation of mitochondrial translation (GO:0070129)2.45482177
129peptide hormone processing (GO:0016486)2.45143309
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44933689
131oxidative phosphorylation (GO:0006119)2.43767647
132regulation of glucocorticoid secretion (GO:2000849)2.43584311
133cellular response to glucagon stimulus (GO:0071377)2.42030887
134tricarboxylic acid cycle (GO:0006099)2.41791321
135sarcoplasmic reticulum calcium ion transport (GO:0070296)2.39462628
136regulation of early endosome to late endosome transport (GO:2000641)2.37789612
137mitochondrial respiratory chain complex assembly (GO:0033108)2.37556731
138cell communication by electrical coupling (GO:0010644)2.36794848
139muscle filament sliding (GO:0030049)2.36694855
140actin-myosin filament sliding (GO:0033275)2.36694855
141regulation of skeletal muscle contraction (GO:0014819)2.34510367
142protein hydroxylation (GO:0018126)2.31629458
143NADH metabolic process (GO:0006734)2.31327002
144regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.30099081
145regulation of calcium ion transmembrane transport (GO:1903169)2.29702545
146regulation of calcium ion transmembrane transporter activity (GO:1901019)2.29702545
147cerebellar Purkinje cell layer development (GO:0021680)2.28889112
148proton transport (GO:0015992)2.28683847
149negative regulation of cation channel activity (GO:2001258)2.27759550
150response to pheromone (GO:0019236)2.27397484
151nucleoside diphosphate catabolic process (GO:0009134)2.27296696
152pattern specification involved in kidney development (GO:0061004)2.25040596
153ribonucleoside triphosphate biosynthetic process (GO:0009201)2.23656941
154hydrogen transport (GO:0006818)2.23133705
155regulation of relaxation of muscle (GO:1901077)2.22429100
156regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.21066808
157calcium-mediated signaling using intracellular calcium source (GO:0035584)2.20122115
158regulation of cardioblast proliferation (GO:0003264)2.19974706
159regulation of secondary heart field cardioblast proliferation (GO:0003266)2.19974706
160astrocyte differentiation (GO:0048708)2.18932249
161cardiac myofibril assembly (GO:0055003)2.17166852
162sequestering of metal ion (GO:0051238)2.15905639
163generation of precursor metabolites and energy (GO:0006091)2.15459013
164neuronal action potential propagation (GO:0019227)2.14467922
165viral transcription (GO:0019083)2.13345847
166positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.12875165
167left/right pattern formation (GO:0060972)2.12136241
168cardiac muscle contraction (GO:0060048)2.11230963
169protein targeting to plasma membrane (GO:0072661)2.09207016
170regulation of actin filament-based movement (GO:1903115)2.08516486
171regulation of corticosteroid hormone secretion (GO:2000846)2.06819524
172activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.06750113
173regulation of synapse structural plasticity (GO:0051823)2.05414102
174regulation of insulin secretion (GO:0050796)2.03820146
175protein targeting to membrane (GO:0006612)2.03001184
176regulation of amyloid precursor protein catabolic process (GO:1902991)2.02505861
177translational termination (GO:0006415)2.01312261
178keratan sulfate catabolic process (GO:0042340)2.01196850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23827092
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.23552866
3EZH2_22144423_ChIP-Seq_EOC_Human3.17145789
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.10913406
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82162182
6* VDR_21846776_ChIP-Seq_THP-1_Human2.68134409
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58947340
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55151210
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45555652
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42820592
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39744377
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38494925
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.38494821
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.37782927
15* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24822825
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20245859
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18367789
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16594449
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13303650
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.09508785
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08795643
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07721206
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.06704664
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05872415
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05872415
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.04431454
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03064690
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01559546
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01083799
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00147279
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97106246
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88476987
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.82826767
34LXR_22292898_ChIP-Seq_THP-1_Human1.81872358
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.75481552
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75343792
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74499971
38XRN2_22483619_ChIP-Seq_HELA_Human1.72076844
39ZNF274_21170338_ChIP-Seq_K562_Hela1.70867129
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68111640
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67748040
42* EP300_21415370_ChIP-Seq_HL-1_Mouse1.59816871
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.58970283
44P68_20966046_ChIP-Seq_HELA_Human1.57101295
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56827772
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56785768
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56225265
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52637459
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51165895
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.51093339
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48550354
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47399957
53BCL6_27268052_Chip-Seq_Bcells_Human1.47390144
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46093962
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45068941
56CTCF_26484167_Chip-Seq_Bcells_Mouse1.44866389
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43774807
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42671317
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.41512426
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.41422872
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41400749
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40872853
63DCP1A_22483619_ChIP-Seq_HELA_Human1.39731365
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39151718
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39141420
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37367493
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37067444
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35795069
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35773765
70BCOR_27268052_Chip-Seq_Bcells_Human1.35719824
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34832261
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.34753260
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33214648
74VDR_24763502_ChIP-Seq_THP-1_Human1.32776970
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29747028
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28100538
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27442513
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27434520
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25731323
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25272103
81MYC_22102868_ChIP-Seq_BL_Human1.24519373
82CLOCK_20551151_ChIP-Seq_293T_Human1.24256292
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23858547
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.23343476
85CTCF_27219007_Chip-Seq_Bcells_Human1.22276452
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22166920
87DROSHA_22980978_ChIP-Seq_HELA_Human1.22081328
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22066440
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21886438
90GABP_19822575_ChIP-Seq_HepG2_Human1.21848260
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21604429
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20456483
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20235235
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18439387
95CTCF_21964334_Chip-Seq_Bcells_Human1.17697501
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17619639
97TFEB_21752829_ChIP-Seq_HELA_Human1.17067761
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16553310
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16141275
100* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15660872
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15254809
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14610701
103MAF_26560356_Chip-Seq_TH2_Human1.13868492
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13435131
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13202732
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12757009
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12436359
108SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12233757
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.11156719
110* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10528889
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.09889920
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09623969
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.09199235
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08738949
115TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08701040
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08126239
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.07507586
118TTF2_22483619_ChIP-Seq_HELA_Human1.07011487
119* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06983008
120* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06983008
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06824232
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06472364
123* KDM2B_26808549_Chip-Seq_DND41_Human1.06259134
124IRF8_22096565_ChIP-ChIP_GC-B_Human1.06245287
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06103415
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06072806
127* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05279419
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05265786
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04334457
130* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04194434
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04052395
132* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03993476
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.03738113
134CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03643648
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03605532
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03251978
137SMC4_20622854_ChIP-Seq_HELA_Human1.02643838
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01964355
139RACK7_27058665_Chip-Seq_MCF-7_Human1.01504627
140STAT1_20625510_ChIP-Seq_HELA_Human1.01092476
141SOX2_20726797_ChIP-Seq_SW620_Human1.00887093
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00828908
143EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00460734
144NCOR1_26117541_ChIP-Seq_K562_Human1.00235960
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.99521546
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.98302798
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.95310955
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94768266
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93692953
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93501627
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.92685857
152RARB_27405468_Chip-Seq_BRAIN_Mouse0.92545267
153REST_21632747_ChIP-Seq_MESCs_Mouse0.91498843
154MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90281430
155RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90023661
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.89534642
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89453274
158GATA1_22025678_ChIP-Seq_K562_Human0.89154215
159ZNF263_19887448_ChIP-Seq_K562_Human0.89092919
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88913734
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88315856
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.88268025
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88193526
164CTCF_20526341_ChIP-Seq_ESCs_Human0.85662368
165TP63_17297297_ChIP-ChIP_HaCaT_Human0.85069523
166CREB1_26743006_Chip-Seq_LNCaP_Human0.83993792
167RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83810073
168SA1_22415368_ChIP-Seq_MEFs_Mouse0.82870391
169TP63_22573176_ChIP-Seq_HFKS_Human0.82285197
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82076640
171SA1_27219007_Chip-Seq_Bcells_Human0.81986934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.77500141
2MP0003806_abnormal_nucleotide_metabolis4.58207806
3MP0000013_abnormal_adipose_tissue3.78489334
4MP0008438_abnormal_cutaneous_collagen3.37445604
5MP0000751_myopathy3.17220950
6MP0009840_abnormal_foam_cell3.15807469
7MP0004510_myositis3.07618720
8MP0002909_abnormal_adrenal_gland2.89765265
9MP0005451_abnormal_body_composition2.88876890
10MP0003186_abnormal_redox_activity2.78894846
11MP0003283_abnormal_digestive_organ2.73555388
12MP0003303_peritoneal_inflammation2.54271034
13MP0000749_muscle_degeneration2.46719204
14MP0001545_abnormal_hematopoietic_system2.42909451
15MP0005397_hematopoietic_system_phenotyp2.42909451
16MP0005464_abnormal_platelet_physiology2.42836602
17MP0003172_abnormal_lysosome_physiology2.39568119
18MP0003075_altered_response_to2.38345667
19MP0005275_abnormal_skin_tensile2.31109113
20MP0005503_abnormal_tendon_morphology2.19903343
21MP0003122_maternal_imprinting2.07226608
22MP0004145_abnormal_muscle_electrophysio2.05831751
23MP0002148_abnormal_hypersensitivity_rea2.05446013
24MP0004036_abnormal_muscle_relaxation2.05060668
25MP0002139_abnormal_hepatobiliary_system1.97784204
26MP0004084_abnormal_cardiac_muscle1.96348953
27MP0010386_abnormal_urinary_bladder1.95937872
28MP0004215_abnormal_myocardial_fiber1.95318172
29MP0009278_abnormal_bone_marrow1.91121967
30MP0002234_abnormal_pharynx_morphology1.89432085
31MP0003646_muscle_fatigue1.87467866
32MP0005165_increased_susceptibility_to1.83415575
33MP0004043_abnormal_pH_regulation1.77417860
34MP0000465_gastrointestinal_hemorrhage1.69869150
35MP0004185_abnormal_adipocyte_glucose1.69451348
36MP0000003_abnormal_adipose_tissue1.68800425
37MP0006276_abnormal_autonomic_nervous1.67729326
38MP0000750_abnormal_muscle_regeneration1.67031739
39MP0000604_amyloidosis1.64761383
40MP0003656_abnormal_erythrocyte_physiolo1.64735100
41MP0002877_abnormal_melanocyte_morpholog1.64504840
42MP0000681_abnormal_thyroid_gland1.63230554
43MP0003191_abnormal_cellular_cholesterol1.60547984
44MP0003453_abnormal_keratinocyte_physiol1.59776126
45MP0006082_CNS_inflammation1.59386678
46MP0009780_abnormal_chondrocyte_physiolo1.59374237
47MP0009333_abnormal_splenocyte_physiolog1.59362951
48MP0004859_abnormal_synaptic_plasticity1.58189897
49MP0004858_abnormal_nervous_system1.52130274
50MP0004130_abnormal_muscle_cell1.47885078
51MP0003279_aneurysm1.46972663
52MP0000747_muscle_weakness1.46175904
53MP0004272_abnormal_basement_membrane1.44864545
54MP0000759_abnormal_skeletal_muscle1.42907398
55MP0005645_abnormal_hypothalamus_physiol1.42660155
56MP0001958_emphysema1.41268749
57MP0001968_abnormal_touch/_nociception1.40502902
58MP0005330_cardiomyopathy1.40403755
59MP0001944_abnormal_pancreas_morphology1.39903710
60MP0006054_spinal_hemorrhage1.37640104
61MP0005166_decreased_susceptibility_to1.34891219
62MP0008260_abnormal_autophagy1.34623866
63MP0002972_abnormal_cardiac_muscle1.34443835
64MP0003959_abnormal_lean_body1.34361157
65MP0002106_abnormal_muscle_physiology1.31483081
66MP0008004_abnormal_stomach_pH1.29816544
67MP0005058_abnormal_lysosome_morphology1.29063488
68MP0002735_abnormal_chemical_nociception1.27120002
69MP0005369_muscle_phenotype1.25782056
70MP0005620_abnormal_muscle_contractility1.25680010
71MP0000678_abnormal_parathyroid_gland1.25435533
72MP0005666_abnormal_adipose_tissue1.25038789
73MP0002295_abnormal_pulmonary_circulatio1.24522571
74MP0004087_abnormal_muscle_fiber1.24099844
75MP0002638_abnormal_pupillary_reflex1.23359935
76MP0002736_abnormal_nociception_after1.23277971
77MP0003195_calcinosis1.23070545
78MP0002269_muscular_atrophy1.22958131
79MP0002693_abnormal_pancreas_physiology1.21877194
80MP0005623_abnormal_meninges_morphology1.20842863
81MP0002896_abnormal_bone_mineralization1.20654443
82MP0001299_abnormal_eye_distance/1.20357104
83MP0008775_abnormal_heart_ventricle1.19401298
84MP0003635_abnormal_synaptic_transmissio1.18684256
85MP0004270_analgesia1.18515070
86MP0005379_endocrine/exocrine_gland_phen1.18243699
87MP0000230_abnormal_systemic_arterial1.17833826
88MP0003436_decreased_susceptibility_to1.17800768
89MP0001853_heart_inflammation1.17093300
90MP0005025_abnormal_response_to1.13615128
91MP0005501_abnormal_skin_physiology1.11517017
92MP0003137_abnormal_impulse_conducting1.11392060
93MP0002733_abnormal_thermal_nociception1.11073504
94MP0008961_abnormal_basal_metabolism1.10992065
95MP0004233_abnormal_muscle_weight1.09042369
96MP0001881_abnormal_mammary_gland1.09028346
97MP0008469_abnormal_protein_level1.07724744
98MP0000858_altered_metastatic_potential1.07444900
99MP0001348_abnormal_lacrimal_gland1.07095024
100MP0001970_abnormal_pain_threshold1.06607847
101MP0001765_abnormal_ion_homeostasis1.05616653
102MP0004808_abnormal_hematopoietic_stem1.04580627
103MP0006036_abnormal_mitochondrial_physio1.03079121
104MP0001270_distended_abdomen1.03057556
105MP0004484_altered_response_of1.01399739
106MP0004085_abnormal_heartbeat1.01162977
107MP0005584_abnormal_enzyme/coenzyme_acti1.01047545
108MP0002163_abnormal_gland_morphology1.00699731
109MP0001529_abnormal_vocalization0.99865053
110MP0002734_abnormal_mechanical_nocicepti0.99096619
111MP0006072_abnormal_retinal_apoptosis0.98283115
112MP0002272_abnormal_nervous_system0.97993909
113MP0005220_abnormal_exocrine_pancreas0.96948242
114MP0006035_abnormal_mitochondrial_morpho0.96243660
115MP0000538_abnormal_urinary_bladder0.96123272
116MP0003879_abnormal_hair_cell0.95850127
117MP0002108_abnormal_muscle_morphology0.95629023
118MP0000358_abnormal_cell_content/0.95418634
119MP0000920_abnormal_myelination0.95216861
120MP0002078_abnormal_glucose_homeostasis0.94054976
121MP0005319_abnormal_enzyme/_coenzyme0.93452985
122MP0005670_abnormal_white_adipose0.93022964
123MP0001664_abnormal_digestion0.92993705
124MP0009384_cardiac_valve_regurgitation0.92909055
125MP0005084_abnormal_gallbladder_morpholo0.92172209
126MP0005375_adipose_tissue_phenotype0.92045546
127MP0002419_abnormal_innate_immunity0.91658878
128MP0005257_abnormal_intraocular_pressure0.90097697
129MP0005000_abnormal_immune_tolerance0.89967526
130MP0002332_abnormal_exercise_endurance0.89411269
131MP0005535_abnormal_body_temperature0.89326465
132MP0000015_abnormal_ear_pigmentation0.88747927
133MP0001764_abnormal_homeostasis0.88592274
134MP0003634_abnormal_glial_cell0.88415489
135MP0008874_decreased_physiological_sensi0.88234931
136MP0009643_abnormal_urine_homeostasis0.88144980
137MP0002132_abnormal_respiratory_system0.86684079
138MP0005385_cardiovascular_system_phenoty0.86460579
139MP0001544_abnormal_cardiovascular_syste0.86460579
140MP0005636_abnormal_mineral_homeostasis0.86259823
141MP0003329_amyloid_beta_deposits0.84883917
142MP0002184_abnormal_innervation0.84480349
143MP0004147_increased_porphyrin_level0.84129510
144MP0000343_altered_response_to0.83782188
145MP0001533_abnormal_skeleton_physiology0.83511337
146MP0009745_abnormal_behavioral_response0.83376411
147MP0001845_abnormal_inflammatory_respons0.83324511
148MP0009785_altered_susceptibility_to0.82680368
149MP0002064_seizures0.81425952
150MP0001756_abnormal_urination0.80409768
151MP0001502_abnormal_circadian_rhythm0.80034466
152MP0001905_abnormal_dopamine_level0.79727539
153MP0005646_abnormal_pituitary_gland0.79703813
154MP0001661_extended_life_span0.79265529
155MP0005266_abnormal_metabolism0.79009779
156MP0000163_abnormal_cartilage_morphology0.78232966
157MP0009764_decreased_sensitivity_to0.77972499
158MP0008007_abnormal_cellular_replicative0.77502912
159MP0005332_abnormal_amino_acid0.77471500
160MP0003183_abnormal_peptide_metabolism0.76456019
161MP0009379_abnormal_foot_pigmentation0.75627322
162MP0003880_abnormal_central_pattern0.75099413
163MP0004947_skin_inflammation0.73945705
164MP0009250_abnormal_appendicular_skeleto0.73243994
165MP0004019_abnormal_vitamin_homeostasis0.72987514
166MP0001542_abnormal_bone_strength0.71626788
167MP0002723_abnormal_immune_serum0.65380786
168MP0008873_increased_physiological_sensi0.64773069
169MP0001873_stomach_inflammation0.64749361
170MP0002998_abnormal_bone_remodeling0.64347874
171MP0000313_abnormal_cell_death0.63884577
172MP0001790_abnormal_immune_system0.62816904
173MP0005387_immune_system_phenotype0.62816904

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.91526065
2Abnormality of liposaccharide metabolism (HP:0010968)4.91526065
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.91526065
4Petechiae (HP:0000967)4.03848910
5Abnormal mitochondria in muscle tissue (HP:0008316)3.97279889
6Acute necrotizing encephalopathy (HP:0006965)3.95910505
7Purpura (HP:0000979)3.87459292
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.57369042
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.41179248
10Mitochondrial inheritance (HP:0001427)3.32572327
11Ragged-red muscle fibers (HP:0003200)3.27575335
12Hyperthyroidism (HP:0000836)3.21243012
13Increased cerebral lipofuscin (HP:0011813)3.21056157
14Progressive macrocephaly (HP:0004481)3.16706018
15Sudden death (HP:0001699)3.13403961
16Protrusio acetabuli (HP:0003179)3.12598177
17Pheochromocytoma (HP:0002666)3.08354564
18Acute encephalopathy (HP:0006846)3.07440336
19Systemic lupus erythematosus (HP:0002725)2.97754926
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.96981156
21Progressive neurologic deterioration (HP:0002344)2.95308272
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.93512876
23Abnormality of cells of the erythroid lineage (HP:0012130)2.93456223
24Neuroendocrine neoplasm (HP:0100634)2.92847580
25Hepatocellular necrosis (HP:0001404)2.88570852
26Renal Fanconi syndrome (HP:0001994)2.87901488
27Axonal loss (HP:0003447)2.83539414
28Achilles tendon contracture (HP:0001771)2.82220799
29Hepatic necrosis (HP:0002605)2.79923511
30Vacuolated lymphocytes (HP:0001922)2.78278526
31Abnormal number of erythroid precursors (HP:0012131)2.77627913
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75165203
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75165203
34Hypercortisolism (HP:0001578)2.69561909
35Asymmetric septal hypertrophy (HP:0001670)2.69392177
36Progressive muscle weakness (HP:0003323)2.69102844
37Loss of speech (HP:0002371)2.68684297
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68346250
39Type 1 muscle fiber predominance (HP:0003803)2.68162326
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66558294
41Calf muscle hypertrophy (HP:0008981)2.64051118
42Abnormality of the Achilles tendon (HP:0005109)2.63890097
43Exercise-induced myalgia (HP:0003738)2.63516291
44Hyperparathyroidism (HP:0000843)2.60606769
45Increased serum ferritin (HP:0003281)2.59714018
46Premature rupture of membranes (HP:0001788)2.59437178
47Myotonia (HP:0002486)2.58650391
48Decreased circulating renin level (HP:0003351)2.58053987
49Increased muscle lipid content (HP:0009058)2.55801200
50Increased CSF lactate (HP:0002490)2.53435260
51Dysostosis multiplex (HP:0000943)2.52879554
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.52606825
53Muscle fiber splitting (HP:0003555)2.52471400
54Muscle hypertrophy of the lower extremities (HP:0008968)2.52243272
55Increased variability in muscle fiber diameter (HP:0003557)2.50295912
56Abnormality of the calf musculature (HP:0001430)2.50288980
57Increased intramyocellular lipid droplets (HP:0012240)2.49820467
58Vertebral compression fractures (HP:0002953)2.49724740
59Hypertensive crisis (HP:0100735)2.48055660
60Palpitations (HP:0001962)2.47655742
61Truncus arteriosus (HP:0001660)2.42897886
62Nuclear cataract (HP:0100018)2.42860488
63Ketoacidosis (HP:0001993)2.40450694
64Myoglobinuria (HP:0002913)2.40276262
65Hepatosplenomegaly (HP:0001433)2.39363383
66Prolonged neonatal jaundice (HP:0006579)2.36629486
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34453488
68Broad metatarsal (HP:0001783)2.32514463
69Bulbar palsy (HP:0001283)2.32018033
70Type II lissencephaly (HP:0007260)2.30989682
71Esophageal neoplasm (HP:0100751)2.29578265
72Neoplasm of head and neck (HP:0012288)2.29578265
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.27728261
74Congenital glaucoma (HP:0001087)2.26640245
75Respiratory failure (HP:0002878)2.25466345
76Generalized aminoaciduria (HP:0002909)2.24498138
77Exercise-induced muscle cramps (HP:0003710)2.24130942
78Macrocytic anemia (HP:0001972)2.22880595
79Obstructive lung disease (HP:0006536)2.20891306
80Chronic obstructive pulmonary disease (HP:0006510)2.20891306
81Ventricular tachycardia (HP:0004756)2.20805662
82Prolonged QT interval (HP:0001657)2.19900045
83Mildly elevated creatine phosphokinase (HP:0008180)2.19124524
84Large for gestational age (HP:0001520)2.18850480
853-Methylglutaconic aciduria (HP:0003535)2.18384970
86Rhabdomyolysis (HP:0003201)2.18053729
87Abnormality of dentin (HP:0010299)2.16927764
88Hypoglycemic coma (HP:0001325)2.15632444
89Broad distal phalanx of finger (HP:0009836)2.15442244
90Paralysis (HP:0003470)2.14553932
91Retinal dysplasia (HP:0007973)2.14037540
92Lipid accumulation in hepatocytes (HP:0006561)2.12826925
93Reticulocytopenia (HP:0001896)2.12727388
94Exercise intolerance (HP:0003546)2.12028795
95Hypokinesia (HP:0002375)2.11254738
96Abnormality of skeletal muscle fiber size (HP:0012084)2.11155377
97Microvesicular hepatic steatosis (HP:0001414)2.10883887
98Agitation (HP:0000713)2.09005074
99Fragile skin (HP:0001030)2.08149895
100Hypoventilation (HP:0002791)2.08028361
101Prolonged bleeding time (HP:0003010)2.07017001
102Microretrognathia (HP:0000308)2.06311924
103Hyperinsulinemic hypoglycemia (HP:0000825)2.05664391
104Distal lower limb muscle weakness (HP:0009053)2.05622046
105Lactic acidosis (HP:0003128)2.04479040
106Hypoglycemic seizures (HP:0002173)2.03820833
107Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03217590
108Dicarboxylic aciduria (HP:0003215)2.03217590
109Increased hepatocellular lipid droplets (HP:0006565)2.03073886
110Mucopolysacchariduria (HP:0008155)2.02614212
111Urinary glycosaminoglycan excretion (HP:0003541)2.02614212
112Spinal rigidity (HP:0003306)2.02010546
113EMG: myopathic abnormalities (HP:0003458)2.01959786
114Oligomenorrhea (HP:0000876)2.01083200
115Difficulty climbing stairs (HP:0003551)2.00898616
116Abnormality of iron homeostasis (HP:0011031)2.00513160
117Cervical subluxation (HP:0003308)2.00238142
118Adrenal overactivity (HP:0002717)1.99239215
119Bundle branch block (HP:0011710)1.97104600
120Respiratory difficulties (HP:0002880)1.96229237
121Exertional dyspnea (HP:0002875)1.95899533
122Anxiety (HP:0000739)1.93934938
123Conjunctival hamartoma (HP:0100780)1.93897083
124Visual hallucinations (HP:0002367)1.93746078
125Menstrual irregularities (HP:0000858)1.93697423
126Testicular atrophy (HP:0000029)1.92992115
127Opisthotonus (HP:0002179)1.92761089
128Growth hormone excess (HP:0000845)1.92084467
129Muscle stiffness (HP:0003552)1.91779971
130Abnormality of polysaccharide metabolism (HP:0011012)1.91456269
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91456269
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91456269
133Lipoatrophy (HP:0100578)1.91429378
134Diaphragmatic weakness (HP:0009113)1.90418204
135Increased connective tissue (HP:0009025)1.87949419
136Dementia (HP:0000726)1.87893428
137Late onset (HP:0003584)1.87167120
138Abnormality of the tricuspid valve (HP:0001702)1.87073018
139Spinal cord compression (HP:0002176)1.86031707
140Beaking of vertebral bodies (HP:0004568)1.84950796
141Hypokalemia (HP:0002900)1.83757522
142Hypothermia (HP:0002045)1.83730647
143Stridor (HP:0010307)1.83673225
144Multiple enchondromatosis (HP:0005701)1.82554740
145Increased serum lactate (HP:0002151)1.82341780
146Ventricular fibrillation (HP:0001663)1.82325879
147Abnormal EKG (HP:0003115)1.80892152
148Myopathic facies (HP:0002058)1.79835248
149Syncope (HP:0001279)1.79517956
150Failure to thrive in infancy (HP:0001531)1.79263848
151Joint stiffness (HP:0001387)1.78983250
152Primary atrial arrhythmia (HP:0001692)1.78021080
153Atrial fibrillation (HP:0005110)1.77995945
154Supraventricular tachycardia (HP:0004755)1.77986314
155Supraventricular arrhythmia (HP:0005115)1.77720432
156Symptomatic seizures (HP:0011145)1.76898093
157Right ventricular cardiomyopathy (HP:0011663)1.76812213
158Thrombocytosis (HP:0001894)1.75135356
159Spastic paraparesis (HP:0002313)1.74939326
160Pallor (HP:0000980)1.74325899
161J-shaped sella turcica (HP:0002680)1.72720984
162Cerebral edema (HP:0002181)1.72671996
163Cerebral aneurysm (HP:0004944)1.72337883
164Emotional lability (HP:0000712)1.71355201
165Neoplasm of the peripheral nervous system (HP:0100007)1.70812238
166Fasciculations (HP:0002380)1.69634609
167Limb-girdle muscle atrophy (HP:0003797)1.68131210
168Trismus (HP:0000211)1.67215344
169Delusions (HP:0000746)1.66627440
170Seborrheic dermatitis (HP:0001051)1.66176428
171Neurofibrillary tangles (HP:0002185)1.65828400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.57381349
2WNK33.19800252
3TRIB33.17128309
4ARAF2.91081056
5MAPK152.81009305
6WNK42.43213459
7ERN12.43170348
8VRK22.37227669
9TAOK22.36318119
10NME22.30120535
11CAMKK22.28025010
12TTN2.24280543
13TESK22.15503230
14NTRK32.13471627
15MYLK2.12197192
16BCKDK2.04638125
17PIK3CG2.02117222
18PKN21.87016308
19MAP2K31.86473141
20NME11.74944821
21NTRK11.73776837
22MAP3K121.71977858
23PIM21.71677184
24PHKG21.70288306
25PHKG11.70288306
26BUB11.64896840
27MST1R1.60461349
28UHMK11.60451151
29EPHB21.59452363
30SCYL21.51743078
31PDGFRA1.48258079
32PRKD31.47901712
33BRAF1.42589323
34KDR1.42041708
35MAP2K21.31495136
36LMTK21.29856313
37PRPF4B1.28632925
38ILK1.28416362
39LIMK11.27618112
40KSR21.25794203
41MAP3K21.25530304
42PAK31.25080757
43INSRR1.17103558
44FER1.13471713
45DDR21.13166914
46TESK11.12865650
47STK161.12574971
48CAMKK11.11266839
49MAP3K31.09494895
50SMG11.09412158
51OBSCN1.09276165
52DAPK31.08397737
53HIPK21.06980456
54FLT31.06770766
55MAP2K61.01164047
56AURKA1.00878670
57MAP3K11.00117287
58DAPK10.99523218
59MINK10.98413944
60MAP2K10.96184467
61MET0.95296653
62TAOK10.94202617
63CAMK2D0.93777338
64IKBKB0.92880816
65TNIK0.92169584
66PINK10.91657712
67LRRK20.90487359
68IRAK20.89814257
69MAPKAPK30.88673652
70PBK0.88591228
71CDK190.88236379
72MUSK0.87288931
73WNK10.86432316
74MAP3K110.86017084
75GRK50.84804546
76MAP3K90.84524508
77PRKG20.83510413
78TYK20.80537481
79LATS20.80096136
80CCNB10.78881643
81DMPK0.77845661
82MAPK120.77449385
83RIPK10.77153244
84MAPK110.75707679
85MOS0.74610962
86PTK20.74500584
87PRKD10.73055073
88RPS6KA20.71993387
89CDK80.71682518
90EIF2AK10.71042734
91PTK2B0.69519620
92ROCK10.68011399
93PKN10.67575564
94PTK60.67251936
95PAK60.66733989
96PRKCE0.66454175
97PAK10.64182553
98BLK0.64114160
99CAMK10.64073753
100CDK50.63416235
101CAMK2G0.62571994
102PRKCH0.60919933
103RPS6KA50.60323145
104CSNK1G30.59900577
105RET0.59845758
106DAPK20.59804962
107TBK10.59228593
108GRK70.57544380
109AKT20.56830308
110JAK30.56729217
111ABL20.55611208
112BMX0.54738128
113PDK20.53017788
114CAMK2A0.52146501
115MAP2K40.50072394
116DYRK1B0.49718295
117VRK10.49025294
118MAPK40.48612942
119PAK40.47763312
120ADRBK10.47503603
121CDK140.46308673
122CAMK2B0.46167575
123RAF10.45993226
124ROCK20.45798675
125MAPKAPK50.45487459
126CDC42BPA0.45229482
127ICK0.45156073
128MATK0.44022167
129PAK20.43829789
130RPS6KL10.43694322
131RPS6KC10.43694322
132TLK10.43326828
133CAMK1D0.42275248
134TGFBR20.41414667
135KSR10.40992750
136PDPK10.40548688
137EPHA30.40245221
138PRKD20.40222450
139SIK10.39757599
140MAP3K70.39502214
141PIM10.37774136
142CHEK20.35504226
143RPS6KB20.33507389
144CDK11A0.33116113
145MAP3K80.32910647
146MAP3K130.30498238
147RIPK40.30374060
148RPS6KA60.30064335
149PRKCD0.29742527
150IRAK40.29035023
151CDK70.27562517
152PRKCI0.27050713
153CDK150.26889347
154CSNK2A10.26578899
155CSNK2A20.25713685

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28503325
2Parkinsons disease_Homo sapiens_hsa050123.82994886
3Alzheimers disease_Homo sapiens_hsa050103.08391778
4Protein export_Homo sapiens_hsa030603.06561031
5Cardiac muscle contraction_Homo sapiens_hsa042602.77517245
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62415477
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.53196627
8Huntingtons disease_Homo sapiens_hsa050162.42590566
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.16975493
10Sulfur metabolism_Homo sapiens_hsa009202.13463405
11Vibrio cholerae infection_Homo sapiens_hsa051102.11218793
12Pyrimidine metabolism_Homo sapiens_hsa002402.05546695
13DNA replication_Homo sapiens_hsa030302.00001635
14Insulin secretion_Homo sapiens_hsa049111.95708526
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86809566
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84851465
17Ribosome_Homo sapiens_hsa030101.70286125
18Synaptic vesicle cycle_Homo sapiens_hsa047211.69144916
19Glutathione metabolism_Homo sapiens_hsa004801.66336617
20Base excision repair_Homo sapiens_hsa034101.62908110
21Fatty acid elongation_Homo sapiens_hsa000621.62794685
22Pentose phosphate pathway_Homo sapiens_hsa000301.55273880
23Dilated cardiomyopathy_Homo sapiens_hsa054141.52571590
24RNA polymerase_Homo sapiens_hsa030201.51341955
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51204441
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50633955
27Collecting duct acid secretion_Homo sapiens_hsa049661.49789542
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43654202
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37103805
30Circadian entrainment_Homo sapiens_hsa047131.35761963
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35397022
32Vitamin B6 metabolism_Homo sapiens_hsa007501.34827041
33Pancreatic secretion_Homo sapiens_hsa049721.25308063
34Cocaine addiction_Homo sapiens_hsa050301.24312250
35Lysosome_Homo sapiens_hsa041421.20966291
36Proteasome_Homo sapiens_hsa030501.20455459
37Amphetamine addiction_Homo sapiens_hsa050311.13570744
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13341856
39Fructose and mannose metabolism_Homo sapiens_hsa000511.13030013
40GABAergic synapse_Homo sapiens_hsa047271.12280632
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11348772
42Other glycan degradation_Homo sapiens_hsa005111.10535213
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10005704
44Systemic lupus erythematosus_Homo sapiens_hsa053221.09526134
45Dopaminergic synapse_Homo sapiens_hsa047281.09415286
46N-Glycan biosynthesis_Homo sapiens_hsa005101.09216881
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07633264
48Gastric acid secretion_Homo sapiens_hsa049711.07003234
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.01481281
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.01144679
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00651407
52Long-term potentiation_Homo sapiens_hsa047201.00187266
53Carbon metabolism_Homo sapiens_hsa012000.99568092
54Arginine and proline metabolism_Homo sapiens_hsa003300.99103506
55Purine metabolism_Homo sapiens_hsa002300.98245952
56Cholinergic synapse_Homo sapiens_hsa047250.97960275
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95563117
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93402927
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92840652
60Serotonergic synapse_Homo sapiens_hsa047260.92141766
61Protein digestion and absorption_Homo sapiens_hsa049740.92079157
62Taste transduction_Homo sapiens_hsa047420.90793951
63Asthma_Homo sapiens_hsa053100.90623870
64Oxytocin signaling pathway_Homo sapiens_hsa049210.89983673
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89571568
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89129709
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88595428
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87641354
69Renin secretion_Homo sapiens_hsa049240.86967225
70Sphingolipid metabolism_Homo sapiens_hsa006000.85025063
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84808153
72Salivary secretion_Homo sapiens_hsa049700.84720089
73Pertussis_Homo sapiens_hsa051330.82007279
74Gap junction_Homo sapiens_hsa045400.80773591
75Phenylalanine metabolism_Homo sapiens_hsa003600.80393836
76Prion diseases_Homo sapiens_hsa050200.78984418
77Sulfur relay system_Homo sapiens_hsa041220.78772983
78Morphine addiction_Homo sapiens_hsa050320.78410018
79Metabolic pathways_Homo sapiens_hsa011000.77968968
80Calcium signaling pathway_Homo sapiens_hsa040200.77587713
81Thyroid hormone synthesis_Homo sapiens_hsa049180.77176741
82Estrogen signaling pathway_Homo sapiens_hsa049150.76887440
83GnRH signaling pathway_Homo sapiens_hsa049120.74805579
84Melanogenesis_Homo sapiens_hsa049160.74191089
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72871584
86Mismatch repair_Homo sapiens_hsa034300.72363734
87Salmonella infection_Homo sapiens_hsa051320.70647933
88Glutamatergic synapse_Homo sapiens_hsa047240.70198501
89Biosynthesis of amino acids_Homo sapiens_hsa012300.70052342
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69643955
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69168182
92ECM-receptor interaction_Homo sapiens_hsa045120.69088804
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.68389844
94Phagosome_Homo sapiens_hsa041450.65655483
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65244345
96Glucagon signaling pathway_Homo sapiens_hsa049220.64551079
97Tyrosine metabolism_Homo sapiens_hsa003500.63710142
98Leishmaniasis_Homo sapiens_hsa051400.63323977
99Nucleotide excision repair_Homo sapiens_hsa034200.63201567
100Insulin signaling pathway_Homo sapiens_hsa049100.60958509
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60877789
102cAMP signaling pathway_Homo sapiens_hsa040240.60861287
103Long-term depression_Homo sapiens_hsa047300.58973487
104Renin-angiotensin system_Homo sapiens_hsa046140.58020373
105Peroxisome_Homo sapiens_hsa041460.57305315
106Type II diabetes mellitus_Homo sapiens_hsa049300.56428853
107Osteoclast differentiation_Homo sapiens_hsa043800.54054332
108Rheumatoid arthritis_Homo sapiens_hsa053230.53398057
109Staphylococcus aureus infection_Homo sapiens_hsa051500.52690953
110Focal adhesion_Homo sapiens_hsa045100.52435894
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.51795222
112Tuberculosis_Homo sapiens_hsa051520.50142354
113Alcoholism_Homo sapiens_hsa050340.49447493
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49023155
115VEGF signaling pathway_Homo sapiens_hsa043700.48961602
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48303243
117Galactose metabolism_Homo sapiens_hsa000520.48090659
118Bladder cancer_Homo sapiens_hsa052190.47817252
119Homologous recombination_Homo sapiens_hsa034400.45375028
120Circadian rhythm_Homo sapiens_hsa047100.44769941
121Nicotine addiction_Homo sapiens_hsa050330.44285053
122Regulation of autophagy_Homo sapiens_hsa041400.42979327
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42818967
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42503758
125Pyruvate metabolism_Homo sapiens_hsa006200.41448348
126Olfactory transduction_Homo sapiens_hsa047400.40493838
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.39943088
128Shigellosis_Homo sapiens_hsa051310.39727289
129Folate biosynthesis_Homo sapiens_hsa007900.38921263
130Amoebiasis_Homo sapiens_hsa051460.38673817
131Arachidonic acid metabolism_Homo sapiens_hsa005900.37758309
132Linoleic acid metabolism_Homo sapiens_hsa005910.37537241
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37200941
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36860150
135Type I diabetes mellitus_Homo sapiens_hsa049400.35998518
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35583992
137Insulin resistance_Homo sapiens_hsa049310.35192164
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34802838
139Mineral absorption_Homo sapiens_hsa049780.33465763
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33009772
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.32797920
142Thyroid cancer_Homo sapiens_hsa052160.31919395
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31829117
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31553763
145Allograft rejection_Homo sapiens_hsa053300.31455287
146One carbon pool by folate_Homo sapiens_hsa006700.30857635
147Malaria_Homo sapiens_hsa051440.30697397
148Glioma_Homo sapiens_hsa052140.30687915
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.29737408
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.29648597
151Fatty acid degradation_Homo sapiens_hsa000710.28273971
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28204902
153Propanoate metabolism_Homo sapiens_hsa006400.27765942
154Fatty acid metabolism_Homo sapiens_hsa012120.26247635
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.24821855
156Endocytosis_Homo sapiens_hsa041440.23720339
157Arginine biosynthesis_Homo sapiens_hsa002200.23229700
158Herpes simplex infection_Homo sapiens_hsa051680.21001230
159Epstein-Barr virus infection_Homo sapiens_hsa051690.18375566
160beta-Alanine metabolism_Homo sapiens_hsa004100.17862108
161Apoptosis_Homo sapiens_hsa042100.15562827

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