NELL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.51417801
2synaptic vesicle maturation (GO:0016188)6.42566132
3locomotory exploration behavior (GO:0035641)6.40775696
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.10575296
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.85418574
6vocalization behavior (GO:0071625)5.76674999
7glutamate secretion (GO:0014047)5.65686454
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.61801677
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.60143983
10synaptic vesicle exocytosis (GO:0016079)5.53253059
11regulation of glutamate receptor signaling pathway (GO:1900449)5.46837186
12regulation of synaptic vesicle exocytosis (GO:2000300)5.16941643
13pyrimidine nucleobase catabolic process (GO:0006208)5.15821519
14protein localization to synapse (GO:0035418)5.15157895
15exploration behavior (GO:0035640)5.13426840
16ionotropic glutamate receptor signaling pathway (GO:0035235)5.02099630
17regulation of neuronal synaptic plasticity (GO:0048168)4.86524940
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.78902298
19layer formation in cerebral cortex (GO:0021819)4.68991017
20neuron cell-cell adhesion (GO:0007158)4.66900735
21regulation of synaptic vesicle transport (GO:1902803)4.62993154
22regulation of synapse structural plasticity (GO:0051823)4.62844795
23neurotransmitter-gated ion channel clustering (GO:0072578)4.57524215
24synaptic transmission, glutamatergic (GO:0035249)4.51449786
25dendritic spine morphogenesis (GO:0060997)4.48289395
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47067200
27neurotransmitter secretion (GO:0007269)4.46003370
28glutamate receptor signaling pathway (GO:0007215)4.39185092
29positive regulation of synapse maturation (GO:0090129)4.29089543
30neuronal action potential propagation (GO:0019227)4.24774698
31nucleobase catabolic process (GO:0046113)4.12832290
32long-term memory (GO:0007616)4.10985754
33proline transport (GO:0015824)4.07397006
34neuron-neuron synaptic transmission (GO:0007270)4.06608874
35positive regulation of membrane potential (GO:0045838)4.04748208
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03883757
37regulation of dendritic spine morphogenesis (GO:0061001)3.97202572
38regulation of synaptic plasticity (GO:0048167)3.87557664
39regulation of postsynaptic membrane potential (GO:0060078)3.81212683
40neuron recognition (GO:0008038)3.79148351
41gamma-aminobutyric acid transport (GO:0015812)3.76571834
42cellular potassium ion homeostasis (GO:0030007)3.75766701
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74202248
44postsynaptic membrane organization (GO:0001941)3.73920500
45establishment of mitochondrion localization (GO:0051654)3.73143991
46activation of protein kinase A activity (GO:0034199)3.64335034
47sodium ion export (GO:0071436)3.61421971
48dendrite morphogenesis (GO:0048813)3.59952210
49axonal fasciculation (GO:0007413)3.58826729
50neuromuscular process controlling balance (GO:0050885)3.58577394
51long-term synaptic potentiation (GO:0060291)3.51847996
52synaptic vesicle endocytosis (GO:0048488)3.51229536
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.51003568
54positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49529107
55neurotransmitter transport (GO:0006836)3.49212546
56retinal ganglion cell axon guidance (GO:0031290)3.49075425
57regulation of neurotransmitter secretion (GO:0046928)3.48740919
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.46528308
59neuromuscular synaptic transmission (GO:0007274)3.44926779
60dendritic spine organization (GO:0097061)3.44907743
61innervation (GO:0060384)3.42586236
62positive regulation of neurotransmitter secretion (GO:0001956)3.40699820
63central nervous system myelination (GO:0022010)3.36612170
64axon ensheathment in central nervous system (GO:0032291)3.36612170
65auditory behavior (GO:0031223)3.36517598
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.35722991
67positive regulation of dendritic spine development (GO:0060999)3.35520057
68regulation of dendritic spine development (GO:0060998)3.35131904
69cell communication by electrical coupling (GO:0010644)3.34178139
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33720352
71transmission of nerve impulse (GO:0019226)3.33543461
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31988089
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.31186640
74regulation of vesicle fusion (GO:0031338)3.30737210
75behavioral defense response (GO:0002209)3.30087908
76behavioral fear response (GO:0001662)3.30087908
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28716843
78short-term memory (GO:0007614)3.27739671
79regulation of neurotransmitter levels (GO:0001505)3.26483996
80regulation of synapse maturation (GO:0090128)3.23481455
81establishment of nucleus localization (GO:0040023)3.23355545
82positive regulation of synapse assembly (GO:0051965)3.22403429
83presynaptic membrane assembly (GO:0097105)3.22264196
84adult walking behavior (GO:0007628)3.21003342
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20688606
86central nervous system projection neuron axonogenesis (GO:0021952)3.17833902
87response to auditory stimulus (GO:0010996)3.16844550
88learning (GO:0007612)3.15154966
89regulation of neurotransmitter transport (GO:0051588)3.15066386
90membrane depolarization (GO:0051899)3.14927085
91negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14798910
92mitochondrion transport along microtubule (GO:0047497)3.12290322
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.12290322
94cell migration in hindbrain (GO:0021535)3.11306095
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10648267
96positive regulation of neurotransmitter transport (GO:0051590)3.10482313
97vesicle transport along microtubule (GO:0047496)3.10470159
98cerebellar Purkinje cell differentiation (GO:0021702)3.10290725
99regulation of synaptic transmission (GO:0050804)3.09727519
100regulation of ARF protein signal transduction (GO:0032012)3.09651601
101regulation of voltage-gated calcium channel activity (GO:1901385)3.09336387
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07048129
103cerebellar granule cell differentiation (GO:0021707)3.05671273
104fear response (GO:0042596)3.05135877
105positive regulation of synaptic transmission (GO:0050806)3.03739751
106central nervous system neuron axonogenesis (GO:0021955)3.03638835
107social behavior (GO:0035176)3.02574391
108intraspecies interaction between organisms (GO:0051703)3.02574391
109response to histamine (GO:0034776)3.01920001
110synapse assembly (GO:0007416)3.00830549
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99458538
112neuromuscular process (GO:0050905)2.99285765
113limb bud formation (GO:0060174)2.99285166
114presynaptic membrane organization (GO:0097090)2.99180461
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97283262
116neuronal ion channel clustering (GO:0045161)2.95958594
117L-amino acid import (GO:0043092)2.95030319
118ephrin receptor signaling pathway (GO:0048013)2.92847429
119membrane depolarization during action potential (GO:0086010)2.86853829
120mechanosensory behavior (GO:0007638)2.85451448
121behavioral response to nicotine (GO:0035095)2.84994829
122negative regulation of dendrite development (GO:2000171)2.79922064
123regulation of dendrite morphogenesis (GO:0048814)2.79839670
124cerebral cortex radially oriented cell migration (GO:0021799)2.79270138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34044030
2* GBX2_23144817_ChIP-Seq_PC3_Human3.28962361
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19805275
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16705802
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06708289
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.87770446
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.80332308
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79199660
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79199660
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70628154
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66791157
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62881163
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62861096
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57943719
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57697432
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.57231890
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46875554
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43851677
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.38322230
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34117587
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34068946
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.30285939
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27326918
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22413727
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19012622
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18796034
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16005018
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15816082
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14195857
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08870081
31AR_21572438_ChIP-Seq_LNCaP_Human1.86375126
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85519710
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69145191
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.61709143
35FUS_26573619_Chip-Seq_HEK293_Human1.60993914
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60835334
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57127261
38SMAD4_21799915_ChIP-Seq_A2780_Human1.55997105
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49520869
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47582726
41ZNF274_21170338_ChIP-Seq_K562_Hela1.43361623
42* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40967546
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39798674
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34888921
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34857967
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.32525300
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30975230
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30416641
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29968522
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29686508
51TAF15_26573619_Chip-Seq_HEK293_Human1.29054783
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28977815
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26835469
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26638926
55* AR_19668381_ChIP-Seq_PC3_Human1.22749519
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22089039
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.22016254
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21431549
59* AR_25329375_ChIP-Seq_VCAP_Human1.21233042
60KDM2B_26808549_Chip-Seq_K562_Human1.20718214
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20152808
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.20094309
63* P300_19829295_ChIP-Seq_ESCs_Human1.19993675
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19479135
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17637242
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.17240077
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16494517
68* SOX9_26525672_Chip-Seq_HEART_Mouse1.16022931
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.14983413
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12619340
71* STAT3_23295773_ChIP-Seq_U87_Human1.12419308
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.12239748
73EWS_26573619_Chip-Seq_HEK293_Human1.11434147
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09486107
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09436060
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09217984
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08372353
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08120936
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07451087
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07445839
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05368544
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04559066
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.04479154
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04393015
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04361506
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04205824
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.03968978
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03631991
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02673775
90* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02236867
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02191439
92* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00963671
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00918297
94* TCF4_23295773_ChIP-Seq_U87_Human0.99933755
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99568699
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98416030
97IGF1R_20145208_ChIP-Seq_DFB_Human0.98235923
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.96757422
99* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96618703
100KDM2B_26808549_Chip-Seq_REH_Human0.96189453
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.96094586
102AHR_22903824_ChIP-Seq_MCF-7_Human0.96050150
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.95254238
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94141694
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93606375
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93501918
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.93328536
108ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93130666
109* RNF2_27304074_Chip-Seq_NSC_Mouse0.92965380
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92560164
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.92309141
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91816493
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91211154
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90958048
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90936729
116TP53_16413492_ChIP-PET_HCT116_Human0.89782180
117RXR_22108803_ChIP-Seq_LS180_Human0.89012632
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88100128
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.87689508
120* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87662999
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86736105
122* RUNX2_22187159_ChIP-Seq_PCA_Human0.85826833
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85248260
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85248260
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84967286
126JUN_21703547_ChIP-Seq_K562_Human0.84898132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.71589628
2MP0003880_abnormal_central_pattern5.00290208
3* MP0003635_abnormal_synaptic_transmissio4.41881535
4MP0004270_analgesia4.01245432
5MP0002063_abnormal_learning/memory/cond3.63170391
6MP0009745_abnormal_behavioral_response3.49550313
7MP0002064_seizures3.19243327
8MP0001968_abnormal_touch/_nociception2.94215330
9MP0005423_abnormal_somatic_nervous2.90732234
10MP0002572_abnormal_emotion/affect_behav2.85850532
11MP0009046_muscle_twitch2.80595310
12MP0002734_abnormal_mechanical_nocicepti2.66171513
13MP0001486_abnormal_startle_reflex2.51333147
14MP0002272_abnormal_nervous_system2.43963519
15MP0009780_abnormal_chondrocyte_physiolo2.39337042
16MP0002822_catalepsy2.37944505
17MP0002736_abnormal_nociception_after2.27706117
18MP0002638_abnormal_pupillary_reflex2.26514359
19MP0002735_abnormal_chemical_nociception2.25380317
20MP0000566_synostosis2.18224656
21MP0001440_abnormal_grooming_behavior2.17665850
22MP0001501_abnormal_sleep_pattern2.10868418
23MP0000778_abnormal_nervous_system2.07416441
24MP0004858_abnormal_nervous_system2.03471224
25MP0003329_amyloid_beta_deposits2.00841413
26MP0002653_abnormal_ependyma_morphology1.97848769
27MP0004811_abnormal_neuron_physiology1.96062883
28MP0003136_yellow_coat_color1.95833960
29MP0002733_abnormal_thermal_nociception1.95544026
30MP0008569_lethality_at_weaning1.89414281
31MP0002184_abnormal_innervation1.88804156
32MP0001970_abnormal_pain_threshold1.87892904
33MP0002067_abnormal_sensory_capabilities1.85995372
34MP0002557_abnormal_social/conspecific_i1.77777957
35MP0000955_abnormal_spinal_cord1.68148701
36MP0002909_abnormal_adrenal_gland1.66314494
37MP0004924_abnormal_behavior1.64826413
38MP0005386_behavior/neurological_phenoty1.64826413
39MP0003879_abnormal_hair_cell1.64615280
40MP0004885_abnormal_endolymph1.59710096
41MP0003787_abnormal_imprinting1.52370082
42MP0005646_abnormal_pituitary_gland1.47596348
43MP0002882_abnormal_neuron_morphology1.47013056
44MP0002066_abnormal_motor_capabilities/c1.43112342
45MP0001346_abnormal_lacrimal_gland1.41047342
46MP0003633_abnormal_nervous_system1.34716284
47MP0006276_abnormal_autonomic_nervous1.32702991
48MP0006292_abnormal_olfactory_placode1.32116970
49MP0005377_hearing/vestibular/ear_phenot1.32104569
50MP0003878_abnormal_ear_physiology1.32104569
51MP0001984_abnormal_olfaction1.30204513
52MP0003121_genomic_imprinting1.28874999
53MP0002152_abnormal_brain_morphology1.19482510
54MP0000026_abnormal_inner_ear1.17927531
55MP0008877_abnormal_DNA_methylation1.16578695
56MP0005645_abnormal_hypothalamus_physiol1.16558901
57MP0001502_abnormal_circadian_rhythm1.16438838
58MP0000569_abnormal_digit_pigmentation1.16071471
59MP0003631_nervous_system_phenotype1.15820687
60MP0005248_abnormal_Harderian_gland1.15530149
61MP0006072_abnormal_retinal_apoptosis1.13593394
62MP0002751_abnormal_autonomic_nervous1.13115872
63MP0003938_abnormal_ear_development1.12241444
64MP0005253_abnormal_eye_physiology1.11026841
65MP0001293_anophthalmia1.08569866
66MP0001905_abnormal_dopamine_level1.08099020
67MP0001485_abnormal_pinna_reflex1.07314381
68MP0004142_abnormal_muscle_tone1.06782771
69MP0004133_heterotaxia1.04856522
70MP0003075_altered_response_to1.04030531
71MP0002102_abnormal_ear_morphology1.03316413
72MP0008789_abnormal_olfactory_epithelium0.99281978
73MP0001529_abnormal_vocalization0.98681184
74MP0001177_atelectasis0.97938989
75MP0001299_abnormal_eye_distance/0.97128301
76MP0002069_abnormal_eating/drinking_beha0.95675871
77MP0000049_abnormal_middle_ear0.95326048
78MP0000751_myopathy0.95058469
79MP0003122_maternal_imprinting0.94430486
80MP0000604_amyloidosis0.91169914
81MP0008872_abnormal_physiological_respon0.90374312
82MP0008961_abnormal_basal_metabolism0.90270288
83MP0000537_abnormal_urethra_morphology0.85303665
84MP0008874_decreased_physiological_sensi0.83561025
85MP0003632_abnormal_nervous_system0.83425571
86MP0002229_neurodegeneration0.83083150
87MP0003119_abnormal_digestive_system0.82229758
88MP0003634_abnormal_glial_cell0.81797954
89MP0002233_abnormal_nose_morphology0.81523418
90MP0004510_myositis0.81502273
91MP0002234_abnormal_pharynx_morphology0.79669831
92MP0010030_abnormal_orbit_morphology0.77838401
93MP0003283_abnormal_digestive_organ0.77256716
94MP0000579_abnormal_nail_morphology0.76557971
95MP0004085_abnormal_heartbeat0.76479270
96MP0001963_abnormal_hearing_physiology0.76015976
97MP0003937_abnormal_limbs/digits/tail_de0.75837957
98MP0001188_hyperpigmentation0.75704289
99MP0005535_abnormal_body_temperature0.75175557
100MP0002249_abnormal_larynx_morphology0.75101140
101MP0005391_vision/eye_phenotype0.74975701
102MP0004742_abnormal_vestibular_system0.73925366
103MP0005394_taste/olfaction_phenotype0.73743013
104MP0005499_abnormal_olfactory_system0.73743013
105MP0005195_abnormal_posterior_eye0.73335288
106MP0003690_abnormal_glial_cell0.73128214
107MP0004145_abnormal_muscle_electrophysio0.72221649
108MP0003890_abnormal_embryonic-extraembry0.71157746
109MP0010386_abnormal_urinary_bladder0.70849121
110MP0000631_abnormal_neuroendocrine_gland0.70658152
111MP0002752_abnormal_somatic_nervous0.69608834
112MP0003861_abnormal_nervous_system0.68634226
113MP0010234_abnormal_vibrissa_follicle0.67626545
114MP0004233_abnormal_muscle_weight0.67549469
115MP0000920_abnormal_myelination0.66960497
116MP0005551_abnormal_eye_electrophysiolog0.66773487
117MP0004484_altered_response_of0.66691293
118MP0002090_abnormal_vision0.66585374
119MP0005623_abnormal_meninges_morphology0.62353674
120MP0001664_abnormal_digestion0.61758787
121MP0000013_abnormal_adipose_tissue0.61374455
122MP0005187_abnormal_penis_morphology0.60465458
123MP0004215_abnormal_myocardial_fiber0.60429245
124MP0003137_abnormal_impulse_conducting0.58942242
125MP0010769_abnormal_survival0.55276769
126MP0004130_abnormal_muscle_cell0.55236819
127MP0003172_abnormal_lysosome_physiology0.54936295
128MP0002837_dystrophic_cardiac_calcinosis0.54829552
129MP0005167_abnormal_blood-brain_barrier0.54264150
130MP0001943_abnormal_respiration0.53664034
131MP0010770_preweaning_lethality0.52116381
132MP0002082_postnatal_lethality0.52116381
133MP0002876_abnormal_thyroid_physiology0.52098627
134MP0010768_mortality/aging0.51516055

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.50312197
2Myokymia (HP:0002411)7.32952851
3Focal seizures (HP:0007359)5.65677833
4Visual hallucinations (HP:0002367)5.34852734
5Epileptic encephalopathy (HP:0200134)4.93685759
6Progressive cerebellar ataxia (HP:0002073)4.34533886
7Atonic seizures (HP:0010819)4.23228582
8Febrile seizures (HP:0002373)4.08778634
9Absence seizures (HP:0002121)3.95201110
10Action tremor (HP:0002345)3.91194437
11Supranuclear gaze palsy (HP:0000605)3.78035904
12Generalized tonic-clonic seizures (HP:0002069)3.69982241
13Broad-based gait (HP:0002136)3.67372900
14Dialeptic seizures (HP:0011146)3.66457886
15Impaired vibration sensation in the lower limbs (HP:0002166)3.65897065
16Mutism (HP:0002300)3.58978809
17Ankle clonus (HP:0011448)3.57609200
18Poor eye contact (HP:0000817)3.54933426
19Abnormality of the lower motor neuron (HP:0002366)3.49186913
20Depression (HP:0000716)3.33672751
21Hyperventilation (HP:0002883)3.30539712
22Papilledema (HP:0001085)3.28781783
23Gaze-evoked nystagmus (HP:0000640)3.20437556
24Urinary bladder sphincter dysfunction (HP:0002839)3.19751922
25Abnormal social behavior (HP:0012433)3.12964044
26Impaired social interactions (HP:0000735)3.12964044
27Dysdiadochokinesis (HP:0002075)3.11281461
28Amblyopia (HP:0000646)3.11057584
29Dysmetria (HP:0001310)3.06428006
30Abnormal eating behavior (HP:0100738)3.00772593
31Postural instability (HP:0002172)2.98845396
32Excessive salivation (HP:0003781)2.94889350
33Drooling (HP:0002307)2.94889350
34Urinary urgency (HP:0000012)2.94703239
35Truncal ataxia (HP:0002078)2.90064457
36Genetic anticipation (HP:0003743)2.89323329
37Anxiety (HP:0000739)2.88771328
38Gait imbalance (HP:0002141)2.82674768
39Cerebral inclusion bodies (HP:0100314)2.80231408
40Megalencephaly (HP:0001355)2.78725922
41Neurofibrillary tangles (HP:0002185)2.75632094
42Impaired smooth pursuit (HP:0007772)2.71891965
43Torticollis (HP:0000473)2.71150300
44Hemiparesis (HP:0001269)2.67351014
45Septo-optic dysplasia (HP:0100842)2.65254492
46Amyotrophic lateral sclerosis (HP:0007354)2.64929691
47Stereotypic behavior (HP:0000733)2.64432089
48Spastic gait (HP:0002064)2.63293753
49Diplopia (HP:0000651)2.62772880
50Abnormality of binocular vision (HP:0011514)2.62772880
51Focal dystonia (HP:0004373)2.62408967
52Short 4th metacarpal (HP:0010044)2.61887129
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61887129
54Intention tremor (HP:0002080)2.58956198
55Epileptiform EEG discharges (HP:0011182)2.53718708
56Progressive inability to walk (HP:0002505)2.53565199
57Bradykinesia (HP:0002067)2.52842193
58Abnormality of the corticospinal tract (HP:0002492)2.51511162
59True hermaphroditism (HP:0010459)2.51140324
60Insidious onset (HP:0003587)2.50540382
61Termporal pattern (HP:0011008)2.50540382
62Fetal akinesia sequence (HP:0001989)2.44065404
63Optic nerve hypoplasia (HP:0000609)2.43146464
64Cutaneous finger syndactyly (HP:0010554)2.42972115
65Split foot (HP:0001839)2.42588494
66Obstructive sleep apnea (HP:0002870)2.42391913
67Impaired vibratory sensation (HP:0002495)2.42047938
68Hemiplegia (HP:0002301)2.41174410
69Abnormality of ocular smooth pursuit (HP:0000617)2.41071916
70Scanning speech (HP:0002168)2.39922295
71EEG with generalized epileptiform discharges (HP:0011198)2.37338872
72Cortical dysplasia (HP:0002539)2.37041284
73Abnormality of the labia minora (HP:0012880)2.35531729
74Aplasia involving bones of the extremities (HP:0009825)2.33664866
75Aplasia involving bones of the upper limbs (HP:0009823)2.33664866
76Aplasia of the phalanges of the hand (HP:0009802)2.33664866
77Annular pancreas (HP:0001734)2.33403913
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.32354613
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32354613
80Congenital primary aphakia (HP:0007707)2.29754168
81Ventricular fibrillation (HP:0001663)2.28383490
82Abnormality of the 4th metacarpal (HP:0010012)2.28185347
83Hypsarrhythmia (HP:0002521)2.28137232
84Medial flaring of the eyebrow (HP:0010747)2.27406929
85Lower limb muscle weakness (HP:0007340)2.26706653
86Vaginal atresia (HP:0000148)2.25736789
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25112466
88Craniofacial dystonia (HP:0012179)2.23054254
89Pointed chin (HP:0000307)2.23041556
90Absent speech (HP:0001344)2.21383454
91Insomnia (HP:0100785)2.20208731
92Genital tract atresia (HP:0001827)2.20110282
93Dysmetric saccades (HP:0000641)2.19463997
94Specific learning disability (HP:0001328)2.19352633
95Polyphagia (HP:0002591)2.19128957
96Inability to walk (HP:0002540)2.16818427
97Inappropriate behavior (HP:0000719)2.16260848
98Nephrogenic diabetes insipidus (HP:0009806)2.14914459
99Cutaneous syndactyly (HP:0012725)2.14418925
100Limb dystonia (HP:0002451)2.13737778
101Oligodactyly (hands) (HP:0001180)2.10110082
102Generalized myoclonic seizures (HP:0002123)2.09171231
103Apathy (HP:0000741)2.09145343
104Broad foot (HP:0001769)2.07937876
105Esophageal atresia (HP:0002032)2.07861077
106Trigonocephaly (HP:0000243)2.06500439
107Pancreatic fibrosis (HP:0100732)2.05555138
108Status epilepticus (HP:0002133)2.03745953
109Anophthalmia (HP:0000528)2.03727322
110Incomplete penetrance (HP:0003829)2.03435357
111Agitation (HP:0000713)2.02503850
112Morphological abnormality of the pyramidal tract (HP:0002062)2.01114884
113Akinesia (HP:0002304)1.99426694
114Nephronophthisis (HP:0000090)1.98874359
115Lower limb asymmetry (HP:0100559)1.98474030
116Hepatoblastoma (HP:0002884)1.95883571
117Abnormality of salivation (HP:0100755)1.94953776
118Gait ataxia (HP:0002066)1.94800994
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94509035
120Bundle branch block (HP:0011710)1.92696027
121Intestinal atresia (HP:0011100)1.92268637
122Postaxial hand polydactyly (HP:0001162)1.90360909
123Pheochromocytoma (HP:0002666)1.90063385
124Abnormal respiratory epithelium morphology (HP:0012253)1.88214539
125Abnormal respiratory motile cilium morphology (HP:0005938)1.88214539
126Midline defect of the nose (HP:0004122)1.87714948
127Clonus (HP:0002169)1.87505043
128Abnormal ciliary motility (HP:0012262)1.87475561
129Delusions (HP:0000746)1.86971672
130Intellectual disability, profound (HP:0002187)1.85576742
131Absent septum pellucidum (HP:0001331)1.85328622
132Lower limb amyotrophy (HP:0007210)1.85193115
133Ankyloglossia (HP:0010296)1.83832462
134Diminished motivation (HP:0000745)1.83171418
135Bronchomalacia (HP:0002780)1.82686333
136Bilateral microphthalmos (HP:0007633)1.82570470
137Lissencephaly (HP:0001339)1.82544319
138Oligodactyly (HP:0012165)1.81817972
139High anterior hairline (HP:0009890)1.81487478
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81287203
141Pancreatic cysts (HP:0001737)1.81027008
142Blue irides (HP:0000635)1.80982239
143Rapidly progressive (HP:0003678)1.80799995
144Neuronal loss in central nervous system (HP:0002529)1.78960014
145Poor coordination (HP:0002370)1.78543525
146Abnormal respiratory motile cilium physiology (HP:0012261)1.77466204
147Rigidity (HP:0002063)1.75934128
148Hypoplasia of the corpus callosum (HP:0002079)1.75039769
149Sleep apnea (HP:0010535)1.74146631
150Humeroradial synostosis (HP:0003041)1.73446396
151Synostosis involving the elbow (HP:0003938)1.73446396
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.72931815
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69371302
154Hypoplasia of the brainstem (HP:0002365)1.69371302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.54291222
2NTRK34.43361313
3MARK14.09335870
4MAP3K93.99466965
5DAPK22.83563572
6MINK12.82689819
7MAP3K42.79285054
8PAK62.35497704
9PRKD32.33176479
10MAP2K72.30605861
11KSR22.25174390
12NTRK22.11538437
13CAMKK11.99260658
14KSR11.94745555
15DAPK11.85534254
16MAP3K121.84021175
17DYRK21.81618131
18MAP2K41.75334566
19EPHA31.69912232
20CASK1.69391303
21NTRK11.62005422
22CDK51.59091253
23WNK31.58985706
24PRPF4B1.53372528
25RIPK41.52047138
26MAP4K21.51661752
27PLK21.50815050
28FGFR21.43662735
29CDK191.43182155
30MAPK131.43063404
31BCR1.39972449
32SIK21.32060890
33TNIK1.31315210
34PRKCG1.26471391
35STK381.23159961
36TYRO31.21225850
37MAP3K21.18297241
38GRK51.17611656
39PHKG21.14080513
40PHKG11.14080513
41ARAF1.13952137
42LATS21.13802400
43DYRK1B1.10972905
44TAOK11.03934501
45FES1.03826838
46EPHB21.01168534
47UHMK11.00808666
48MAP3K131.00767838
49CDK181.00410105
50BRD40.99880643
51CDK150.98792638
52MAPK150.98556224
53CDK140.93578603
54CAMK10.93183145
55CAMK2A0.92587669
56RAF10.91578405
57PNCK0.89065353
58STK110.88487107
59CDK11A0.86505351
60PTK2B0.85904211
61CAMK2B0.81447236
62RET0.80694667
63PRKCH0.79049294
64PAK30.78729302
65ALK0.78361988
66CAMKK20.77720713
67TXK0.77284665
68SGK4940.75810336
69SGK2230.75810336
70CCNB10.74264720
71CSNK1G20.72850941
72MARK20.72816758
73DYRK1A0.71529111
74PDK10.70378629
75MKNK10.68104929
76PKN10.67130922
77LMTK20.66920962
78SGK10.64388162
79ERBB20.62535161
80CSNK1G30.62361970
81DYRK30.62200914
82PASK0.61930179
83TRIM280.61130656
84SGK20.59838093
85PDPK10.58485343
86PRKCZ0.57639017
87OXSR10.57629031
88CSNK1A1L0.57260597
89MAP3K100.56917183
90SGK30.56765180
91NEK10.55701714
92CSNK1G10.55286168
93MKNK20.54820480
94PINK10.52865982
95NME10.51951322
96MAP3K70.51333328
97SCYL20.50956597
98BMPR20.50047348
99ERBB30.49324698
100BRSK10.48497515
101FYN0.47907656
102MAP3K10.47294157
103RPS6KA30.46246042
104DAPK30.45010260
105CAMK40.41676367
106RIPK10.40867503
107PRKCE0.40259696
108FER0.40206944
109FGR0.37488326
110MAPK100.37400092
111CAMK1D0.37099596
112MAPK120.36984253
113CDC42BPA0.36247691
114MAP3K60.35767800
115MAP2K10.35576085
116DMPK0.35370458
117TSSK60.33889358
118CDK30.33393786
119ADRBK20.33213175
120CAMK2G0.32947247
121CAMK1G0.32799396
122NEK60.32408634
123RPS6KA20.32148255
124CSNK1D0.31393241
125CSNK1E0.31320345
126CAMK2D0.30402379
127ROCK20.29440958
128PRKACA0.29299670
129DDR20.28702609
130PRKCB0.27091641
131SRPK10.26183643
132PRKDC0.24721122
133BCKDK0.22741105
134PRKACB0.22586505

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.64898471
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27100304
3Long-term potentiation_Homo sapiens_hsa047202.84566167
4Circadian entrainment_Homo sapiens_hsa047132.79455896
5Olfactory transduction_Homo sapiens_hsa047402.78645387
6Glutamatergic synapse_Homo sapiens_hsa047242.62296031
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60662847
8GABAergic synapse_Homo sapiens_hsa047272.56241796
9Amphetamine addiction_Homo sapiens_hsa050312.50319358
10Morphine addiction_Homo sapiens_hsa050322.39720407
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29479376
12Salivary secretion_Homo sapiens_hsa049702.19866476
13Dopaminergic synapse_Homo sapiens_hsa047282.16904451
14Insulin secretion_Homo sapiens_hsa049111.97378345
15Cholinergic synapse_Homo sapiens_hsa047251.96786140
16Gastric acid secretion_Homo sapiens_hsa049711.95890177
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91213193
18Oxytocin signaling pathway_Homo sapiens_hsa049211.72013442
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71904696
20Long-term depression_Homo sapiens_hsa047301.68912092
21Renin secretion_Homo sapiens_hsa049241.61430334
22Calcium signaling pathway_Homo sapiens_hsa040201.57256172
23Taste transduction_Homo sapiens_hsa047421.53988827
24Basal cell carcinoma_Homo sapiens_hsa052171.52621984
25GnRH signaling pathway_Homo sapiens_hsa049121.52263939
26Hedgehog signaling pathway_Homo sapiens_hsa043401.50140890
27Serotonergic synapse_Homo sapiens_hsa047261.48361457
28Cocaine addiction_Homo sapiens_hsa050301.48323122
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47182527
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41861227
31Gap junction_Homo sapiens_hsa045401.40748021
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37059972
33Glioma_Homo sapiens_hsa052141.36582817
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32908485
35Axon guidance_Homo sapiens_hsa043601.31417940
36cAMP signaling pathway_Homo sapiens_hsa040241.27141861
37Collecting duct acid secretion_Homo sapiens_hsa049661.23694107
38Estrogen signaling pathway_Homo sapiens_hsa049151.22553391
39Type II diabetes mellitus_Homo sapiens_hsa049301.20916343
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17417576
41ErbB signaling pathway_Homo sapiens_hsa040121.15166609
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13573222
43Hippo signaling pathway_Homo sapiens_hsa043901.12874491
44Melanogenesis_Homo sapiens_hsa049161.10782709
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05265841
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04529953
47Oocyte meiosis_Homo sapiens_hsa041141.00792060
48Nitrogen metabolism_Homo sapiens_hsa009100.97755947
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91468128
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.88919752
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.88868780
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86532473
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85292439
54Dorso-ventral axis formation_Homo sapiens_hsa043200.83078271
55Vibrio cholerae infection_Homo sapiens_hsa051100.80556987
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80537157
57VEGF signaling pathway_Homo sapiens_hsa043700.78579586
58Choline metabolism in cancer_Homo sapiens_hsa052310.78420990
59Pancreatic secretion_Homo sapiens_hsa049720.77617223
60Steroid biosynthesis_Homo sapiens_hsa001000.77393192
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.76611543
62Cardiac muscle contraction_Homo sapiens_hsa042600.75302018
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74577311
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74097435
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73791570
66MAPK signaling pathway_Homo sapiens_hsa040100.71060873
67Dilated cardiomyopathy_Homo sapiens_hsa054140.68282251
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67051202
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66349206
70Alzheimers disease_Homo sapiens_hsa050100.63558924
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63173591
72mTOR signaling pathway_Homo sapiens_hsa041500.63078815
73Ras signaling pathway_Homo sapiens_hsa040140.61362930
74Endometrial cancer_Homo sapiens_hsa052130.61202801
75Rap1 signaling pathway_Homo sapiens_hsa040150.61123442
76Glucagon signaling pathway_Homo sapiens_hsa049220.60847807
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59558457
78Oxidative phosphorylation_Homo sapiens_hsa001900.59207044
79Phototransduction_Homo sapiens_hsa047440.57724980
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.57676065
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56804237
82Non-small cell lung cancer_Homo sapiens_hsa052230.55402785
83Endocytosis_Homo sapiens_hsa041440.55226245
84Regulation of autophagy_Homo sapiens_hsa041400.54163328
85Parkinsons disease_Homo sapiens_hsa050120.53261208
86Renal cell carcinoma_Homo sapiens_hsa052110.49001081
87Alcoholism_Homo sapiens_hsa050340.48958118
88Wnt signaling pathway_Homo sapiens_hsa043100.48510754
89Bile secretion_Homo sapiens_hsa049760.47896146
90Butanoate metabolism_Homo sapiens_hsa006500.47603272
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46842928
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46591294
93Huntingtons disease_Homo sapiens_hsa050160.46497030
94Prion diseases_Homo sapiens_hsa050200.46412178
95Tight junction_Homo sapiens_hsa045300.45749060
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45732433
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43841250
98Insulin signaling pathway_Homo sapiens_hsa049100.43474341
99Inositol phosphate metabolism_Homo sapiens_hsa005620.42074944
100Colorectal cancer_Homo sapiens_hsa052100.41179877
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40695939
102Type I diabetes mellitus_Homo sapiens_hsa049400.40416836
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38628351
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38274269
105Notch signaling pathway_Homo sapiens_hsa043300.38108034
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36759550
107Chemokine signaling pathway_Homo sapiens_hsa040620.34990875
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34569068
109Circadian rhythm_Homo sapiens_hsa047100.33966288
110African trypanosomiasis_Homo sapiens_hsa051430.33832128
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31190501
112mRNA surveillance pathway_Homo sapiens_hsa030150.29473027
113Ovarian steroidogenesis_Homo sapiens_hsa049130.27976896
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.27194776
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27175727
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26735941
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26418077
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25853071
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25316247
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25051225
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20991960

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