NEK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)3.98786028
2regulation of fatty acid beta-oxidation (GO:0031998)3.94655989
3positive regulation of fatty acid beta-oxidation (GO:0032000)3.84594612
4positive regulation of histone deacetylation (GO:0031065)3.81154810
5interkinetic nuclear migration (GO:0022027)3.76380241
6carnitine shuttle (GO:0006853)3.74030665
7fatty acid transmembrane transport (GO:1902001)3.64734063
8sarcomere organization (GO:0045214)3.58844070
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.56623697
10cardiac myofibril assembly (GO:0055003)3.51984964
11antigen processing and presentation of endogenous antigen (GO:0019883)3.49040325
12regulation of fatty acid oxidation (GO:0046320)3.43875180
13muscle filament sliding (GO:0030049)3.41598152
14actin-myosin filament sliding (GO:0033275)3.41598152
15negative regulation of erythrocyte differentiation (GO:0045647)3.41229943
16positive thymic T cell selection (GO:0045059)3.32769170
172-oxoglutarate metabolic process (GO:0006103)3.32176364
18valine metabolic process (GO:0006573)3.30360252
19negative thymic T cell selection (GO:0045060)3.29187174
20positive regulation of fatty acid oxidation (GO:0046321)3.27704267
21negative regulation of fatty acid transport (GO:2000192)3.27549971
22lysine metabolic process (GO:0006553)3.25231704
23lysine catabolic process (GO:0006554)3.25231704
24histone H3-K36 demethylation (GO:0070544)3.20190128
25regulation of sequestering of triglyceride (GO:0010889)3.19234727
26positive regulation of gamma-delta T cell activation (GO:0046645)3.18908731
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12561176
28myofibril assembly (GO:0030239)3.12118795
29apoptotic cell clearance (GO:0043277)3.10059948
30negative T cell selection (GO:0043383)3.04795554
31insulin-like growth factor receptor signaling pathway (GO:0048009)2.97689802
32thymic T cell selection (GO:0045061)2.95927317
33low-density lipoprotein particle clearance (GO:0034383)2.94207693
34negative regulation of cell size (GO:0045792)2.93183014
35tricarboxylic acid metabolic process (GO:0072350)2.89480281
36B cell receptor signaling pathway (GO:0050853)2.89195029
37positive regulation of glycogen biosynthetic process (GO:0045725)2.89002177
38regulation of cholesterol storage (GO:0010885)2.88977157
39negative regulation of myotube differentiation (GO:0010832)2.87578655
40vascular endothelial growth factor signaling pathway (GO:0038084)2.87398703
41negative regulation of cardiac muscle tissue growth (GO:0055022)2.87341798
42negative regulation of heart growth (GO:0061117)2.87341798
43regulation of gamma-delta T cell activation (GO:0046643)2.86722430
44growth hormone receptor signaling pathway (GO:0060396)2.84727071
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84658809
46carnitine transmembrane transport (GO:1902603)2.81719421
47cytoplasmic mRNA processing body assembly (GO:0033962)2.81622014
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.79424056
49negative regulation of cell killing (GO:0031342)2.76342832
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76342832
51actin-mediated cell contraction (GO:0070252)2.75628026
52tricarboxylic acid cycle (GO:0006099)2.73296990
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71129406
54regulation of skeletal muscle contraction (GO:0014819)2.70135652
55NLS-bearing protein import into nucleus (GO:0006607)2.67777610
56alpha-linolenic acid metabolic process (GO:0036109)2.67263126
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65306114
58protein localization to endosome (GO:0036010)2.64072140
59actin filament-based movement (GO:0030048)2.63931333
60carnitine transport (GO:0015879)2.61723215
61amino-acid betaine transport (GO:0015838)2.61723215
624-hydroxyproline metabolic process (GO:0019471)2.60680563
63intracellular lipid transport (GO:0032365)2.60583714
64positive regulation of CREB transcription factor activity (GO:0032793)2.60369742
65histone H3-K9 demethylation (GO:0033169)2.60134963
66skeletal muscle adaptation (GO:0043501)2.57777844
67actomyosin structure organization (GO:0031032)2.57140919
68positive T cell selection (GO:0043368)2.57138543
69positive regulation of p38MAPK cascade (GO:1900745)2.56952123
70positive regulation of lipid storage (GO:0010884)2.56670644
71fatty acid beta-oxidation (GO:0006635)2.55768959
72basement membrane organization (GO:0071711)2.55176062
73antigen processing and presentation via MHC class Ib (GO:0002475)2.54552155
74adherens junction assembly (GO:0034333)2.54486666
75cell-substrate junction assembly (GO:0007044)2.53364215
76positive regulation of protein deacetylation (GO:0090312)2.53099895
77cellular response to growth hormone stimulus (GO:0071378)2.48874766
78phospholipid homeostasis (GO:0055091)2.48186151
79coronary vasculature morphogenesis (GO:0060977)2.46704405
80creatine metabolic process (GO:0006600)2.46044372
81regulation of gamma-delta T cell differentiation (GO:0045586)2.45817015
82macroautophagy (GO:0016236)2.45783101
83pericardium development (GO:0060039)2.45273951
84peptidyl-lysine dimethylation (GO:0018027)2.45114824
85T cell selection (GO:0045058)2.44122656
86cardiac muscle contraction (GO:0060048)2.42857259
87venous blood vessel morphogenesis (GO:0048845)2.42452661
88regulation of p38MAPK cascade (GO:1900744)2.42384496
89cell-substrate adherens junction assembly (GO:0007045)2.41414689
90focal adhesion assembly (GO:0048041)2.41414689
91regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41310431
92regulation of cholesterol homeostasis (GO:2000188)2.41017755
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40368940
94positive regulation of glycogen metabolic process (GO:0070875)2.40241457
95cell migration involved in sprouting angiogenesis (GO:0002042)2.39981522
96CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.39821299
97oxaloacetate metabolic process (GO:0006107)2.39752981
98maternal placenta development (GO:0001893)2.38011624
99negative regulation of leukocyte chemotaxis (GO:0002689)2.37506231
100hippo signaling (GO:0035329)2.36899488
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35826007
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35826007
103regulation of necroptotic process (GO:0060544)2.35538650
104cardiac muscle hypertrophy (GO:0003300)2.35137933
105cell adhesion mediated by integrin (GO:0033627)2.34903868
106dicarboxylic acid biosynthetic process (GO:0043650)2.34903788
107mannose metabolic process (GO:0006013)2.34262971
108cell migration involved in heart development (GO:0060973)2.33748404
109cellular response to epinephrine stimulus (GO:0071872)2.33659339
110histone lysine demethylation (GO:0070076)2.32558007
111glomerular filtration (GO:0003094)2.31967932
112complement activation, alternative pathway (GO:0006957)2.31329765
113activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30270101
114protein hydroxylation (GO:0018126)2.29712569
115positive regulation of myotube differentiation (GO:0010831)2.29186582
116positive regulation of lipid catabolic process (GO:0050996)2.28382585
117blood vessel endothelial cell migration (GO:0043534)2.28252220
118regulation of glucose import in response to insulin stimulus (GO:2001273)2.28023525
119germinal center formation (GO:0002467)2.27653670
120striated muscle adaptation (GO:0014888)2.26315498
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.26209794
122negative regulation of granulocyte differentiation (GO:0030853)2.26140750
123phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.25546481
124cellular response to exogenous dsRNA (GO:0071360)2.25368615
125striated muscle hypertrophy (GO:0014897)2.25317484
126gland morphogenesis (GO:0022612)2.24653052
127positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.24569124
128endodermal cell differentiation (GO:0035987)2.24340784
129positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23362392
130epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23339771
131cortical actin cytoskeleton organization (GO:0030866)2.23085371
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.22768547
133striated muscle atrophy (GO:0014891)2.22568922
134fatty acid oxidation (GO:0019395)2.22562637
135renal filtration (GO:0097205)2.22147481
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.21057018
137positive regulation of nuclease activity (GO:0032075)2.20633489
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.20415135
139cardiac muscle hypertrophy in response to stress (GO:0014898)2.20384322
140muscle hypertrophy in response to stress (GO:0003299)2.20384322
141cardiac muscle adaptation (GO:0014887)2.20384322
142heart trabecula formation (GO:0060347)2.19747949
143regulation of NFAT protein import into nucleus (GO:0051532)2.19557671
144stress fiber assembly (GO:0043149)2.19501735
145nucleus localization (GO:0051647)2.19363726
146negative regulation of fatty acid metabolic process (GO:0045922)2.19267770
147negative regulation of lipid transport (GO:0032369)2.18064225
148epithelial cell-cell adhesion (GO:0090136)2.18051866
149import into cell (GO:0098657)2.17910796
150histone demethylation (GO:0016577)2.15327285
151positive regulation of Rap GTPase activity (GO:0032854)2.14817998
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.12488463
153response to laminar fluid shear stress (GO:0034616)2.09990766
154cell proliferation involved in metanephros development (GO:0072203)2.09875093
155muscle hypertrophy (GO:0014896)2.08547434
156negative regulation of smooth muscle cell differentiation (GO:0051151)2.07848909
157cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.05733932
158regulation of ARF protein signal transduction (GO:0032012)2.04732539
159regulation of extracellular matrix disassembly (GO:0010715)2.03827439
160positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.01318406
161endocardial cushion development (GO:0003197)1.99675277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30386071
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.02337592
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.53777100
4CLOCK_20551151_ChIP-Seq_293T_Human3.19989378
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68654719
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.65432342
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54489765
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52900290
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.51471202
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44688591
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.37340696
12MYC_22102868_ChIP-Seq_BL_Human2.27494637
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25723282
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15108181
15TCF7_22412390_ChIP-Seq_EML_Mouse2.14681437
16ZNF263_19887448_ChIP-Seq_K562_Human2.13988817
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12603298
18KDM2B_26808549_Chip-Seq_DND41_Human1.99374838
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97591069
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.96781955
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92648480
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.90161094
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.90161094
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87919980
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86307187
26* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85263952
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.83078632
28VDR_21846776_ChIP-Seq_THP-1_Human1.81318881
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79840028
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.77287280
31GATA1_22025678_ChIP-Seq_K562_Human1.76975437
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.76025218
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74986298
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72372683
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69820921
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67964971
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62933780
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60666677
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60159930
40MAF_26560356_Chip-Seq_TH1_Human1.57576194
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57184385
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.57129793
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.54406526
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53470991
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51366751
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50779130
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50250513
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49450999
49FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.48049532
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43126698
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42071899
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41538504
53LXR_22292898_ChIP-Seq_THP-1_Human1.40210442
54SPI1_23127762_ChIP-Seq_K562_Human1.40124633
55RACK7_27058665_Chip-Seq_MCF-7_Human1.39318976
56UTX_26944678_Chip-Seq_JUKART_Human1.35770972
57DROSHA_22980978_ChIP-Seq_HELA_Human1.33990958
58GATA1_19941826_ChIP-Seq_K562_Human1.32990620
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.32940380
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.32201978
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30888859
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30736576
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30456258
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.30336137
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.30147086
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29797082
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29772172
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28412628
69VDR_24763502_ChIP-Seq_THP-1_Human1.28390579
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.28090602
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.27797685
72ATF3_27146783_Chip-Seq_COLON_Human1.27646878
73* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27367043
74RUNX_20019798_ChIP-Seq_JUKART_Human1.25798259
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25722115
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24805292
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24539866
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23982119
79SCL_19346495_ChIP-Seq_HPC-7_Human1.23339278
80NCOR1_26117541_ChIP-Seq_K562_Human1.22756778
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21908829
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20999440
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.20424541
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19692310
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19050372
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17586238
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16548001
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16436353
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15073055
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15066096
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14860494
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.13871175
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12421365
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10778471
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10723548
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08277028
97AR_21572438_ChIP-Seq_LNCaP_Human1.08133443
98KDM2B_26808549_Chip-Seq_K562_Human1.07756977
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.06700200
100GATA2_19941826_ChIP-Seq_K562_Human1.06562912
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05306541
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04833284
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04419054
104TP53_22127205_ChIP-Seq_IMR90_Human1.03548266
105SMC4_20622854_ChIP-Seq_HELA_Human1.03340948
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03306057
107MAF_26560356_Chip-Seq_TH2_Human1.02886606
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01884260
109MYB_26560356_Chip-Seq_TH2_Human1.01438797
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00002847
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99480153
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98916549
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.98581309
114VDR_24787735_ChIP-Seq_THP-1_Human0.97959595
115MYB_26560356_Chip-Seq_TH1_Human0.97629543
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96481410
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.95594369
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95163146
119* MYC_27129775_Chip-Seq_CORNEA_Mouse0.93753510
120* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93690076
121CREB1_26743006_Chip-Seq_LNCaP_Human0.93084702
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91916752
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91263545
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90365192
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.89508071
126P68_20966046_ChIP-Seq_HELA_Human0.89394045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.50419547
2MP0004084_abnormal_cardiac_muscle2.93345066
3MP0008438_abnormal_cutaneous_collagen2.90025703
4MP0002837_dystrophic_cardiac_calcinosis2.77993438
5MP0004130_abnormal_muscle_cell2.64529969
6MP0000751_myopathy2.42720542
7MP0002009_preneoplasia2.28212354
8MP0004036_abnormal_muscle_relaxation2.21970542
9MP0004087_abnormal_muscle_fiber2.11793212
10MP0003300_gastrointestinal_ulcer2.06767067
11MP0004185_abnormal_adipocyte_glucose2.00744379
12MP0001661_extended_life_span1.95417234
13MP0003566_abnormal_cell_adhesion1.94648084
14MP0005666_abnormal_adipose_tissue1.89316529
15MP0003763_abnormal_thymus_physiology1.88370180
16MP0000749_muscle_degeneration1.88058081
17MP0000733_abnormal_muscle_development1.86462311
18MP0010630_abnormal_cardiac_muscle1.86071472
19MP0002396_abnormal_hematopoietic_system1.86033623
20MP0003191_abnormal_cellular_cholesterol1.85356881
21MP0005330_cardiomyopathy1.83816157
22MP0006054_spinal_hemorrhage1.83221744
23MP0001348_abnormal_lacrimal_gland1.80986711
24MP0003646_muscle_fatigue1.79947779
25MP0002877_abnormal_melanocyte_morpholog1.74574411
26MP0005670_abnormal_white_adipose1.74155415
27MP0003283_abnormal_digestive_organ1.68116820
28MP0010352_gastrointestinal_tract_polyps1.63990122
29MP0003279_aneurysm1.59188745
30MP0000747_muscle_weakness1.57070369
31MP0000750_abnormal_muscle_regeneration1.56749779
32MP0005076_abnormal_cell_differentiation1.55993466
33MP0002269_muscular_atrophy1.53152126
34MP0002106_abnormal_muscle_physiology1.51235198
35MP0004858_abnormal_nervous_system1.50563935
36MP0004510_myositis1.49058887
37MP0005409_darkened_coat_color1.48545388
38MP0003252_abnormal_bile_duct1.48122184
39MP0001544_abnormal_cardiovascular_syste1.46155532
40MP0005385_cardiovascular_system_phenoty1.46155532
41MP0009840_abnormal_foam_cell1.44076367
42MP0005375_adipose_tissue_phenotype1.43594110
43MP0005275_abnormal_skin_tensile1.42997685
44MP0008775_abnormal_heart_ventricle1.39362318
45MP0006138_congestive_heart_failure1.37632358
46MP0005620_abnormal_muscle_contractility1.36389252
47MP0003303_peritoneal_inflammation1.36294042
48MP0000759_abnormal_skeletal_muscle1.36292692
49MP0002972_abnormal_cardiac_muscle1.34233761
50MP0004215_abnormal_myocardial_fiber1.33733687
51MP0004272_abnormal_basement_membrane1.33234068
52MP0001958_emphysema1.32739010
53MP0009278_abnormal_bone_marrow1.32561929
54MP0005451_abnormal_body_composition1.31818096
55MP0004233_abnormal_muscle_weight1.28288835
56MP0001790_abnormal_immune_system1.27495850
57MP0005387_immune_system_phenotype1.27495850
58MP0003567_abnormal_fetal_cardiomyocyte1.26196180
59MP0005369_muscle_phenotype1.23508612
60MP0010368_abnormal_lymphatic_system1.20606199
61MP0001800_abnormal_humoral_immune1.19292222
62MP0005058_abnormal_lysosome_morphology1.19225261
63MP0010329_abnormal_lipoprotein_level1.18437231
64MP0008961_abnormal_basal_metabolism1.17497751
65MP0003828_pulmonary_edema1.16821273
66MP0004145_abnormal_muscle_electrophysio1.15434882
67MP0005623_abnormal_meninges_morphology1.14789524
68MP0005360_urolithiasis1.13691642
69MP0005167_abnormal_blood-brain_barrier1.13474397
70MP0001851_eye_inflammation1.11930158
71MP0002139_abnormal_hepatobiliary_system1.11401359
72MP0001835_abnormal_antigen_presentation1.10620381
73MP0001879_abnormal_lymphatic_vessel1.09957656
74MP0003045_fibrosis1.09361046
75MP0002166_altered_tumor_susceptibility1.09354027
76MP0005023_abnormal_wound_healing1.09158373
77MP0000343_altered_response_to1.08434777
78MP0002127_abnormal_cardiovascular_syste1.07640329
79MP0000767_abnormal_smooth_muscle1.06892627
80MP0002128_abnormal_blood_circulation1.06785621
81MP0003221_abnormal_cardiomyocyte_apopto1.06147462
82MP0000003_abnormal_adipose_tissue1.02824324
83MP0004484_altered_response_of1.02073657
84MP0000266_abnormal_heart_morphology1.01589514
85MP0002971_abnormal_brown_adipose1.01154568
86MP0004808_abnormal_hematopoietic_stem1.00983247
87MP0005085_abnormal_gallbladder_physiolo1.00735711
88MP0001915_intracranial_hemorrhage0.99430039
89MP0000609_abnormal_liver_physiology0.97700166
90MP0001986_abnormal_taste_sensitivity0.97619328
91MP0003115_abnormal_respiratory_system0.97126982
92MP0010307_abnormal_tumor_latency0.95857873
93MP0005365_abnormal_bile_salt0.94395266
94MP0010234_abnormal_vibrissa_follicle0.94359747
95MP0001849_ear_inflammation0.93968280
96MP0002933_joint_inflammation0.93828980
97MP0000428_abnormal_craniofacial_morphol0.91812638
98MP0002108_abnormal_muscle_morphology0.90403774
99MP0009053_abnormal_anal_canal0.89925092
100MP0000569_abnormal_digit_pigmentation0.88853447
101MP0003091_abnormal_cell_migration0.87110931
102MP0000249_abnormal_blood_vessel0.86858747
103MP0002925_abnormal_cardiovascular_devel0.86570307
104MP0002998_abnormal_bone_remodeling0.86540908
105MP0002249_abnormal_larynx_morphology0.84098276
106MP0009115_abnormal_fat_cell0.83829164
107MP0005187_abnormal_penis_morphology0.83372739
108MP0002138_abnormal_hepatobiliary_system0.80989528
109MP0003172_abnormal_lysosome_physiology0.80607822
110MP0002896_abnormal_bone_mineralization0.79565813
111MP0001614_abnormal_blood_vessel0.77887638
112MP0004197_abnormal_fetal_growth/weight/0.77701508
113MP0005503_abnormal_tendon_morphology0.77643072
114MP0002006_tumorigenesis0.77624869
115MP0002168_other_aberrant_phenotype0.76225163
116MP0002932_abnormal_joint_morphology0.76154564
117MP0005319_abnormal_enzyme/_coenzyme0.74289944
118MP0002118_abnormal_lipid_homeostasis0.74273038
119MP0000013_abnormal_adipose_tissue0.74258751
120MP0000598_abnormal_liver_morphology0.73393546
121MP0005334_abnormal_fat_pad0.72684355
122MP0009384_cardiac_valve_regurgitation0.72537057
123MP0003436_decreased_susceptibility_to0.72494924
124MP0005464_abnormal_platelet_physiology0.71893000
125MP0002088_abnormal_embryonic_growth/wei0.71056970
126MP0000685_abnormal_immune_system0.70948002
127MP0004947_skin_inflammation0.70478269
128MP0003984_embryonic_growth_retardation0.70411289
129MP0001175_abnormal_lung_morphology0.70180177
130MP0002970_abnormal_white_adipose0.69185396
131MP0000383_abnormal_hair_follicle0.68988680
132MP0002133_abnormal_respiratory_system0.68606854
133MP0005388_respiratory_system_phenotype0.68606854

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.14694322
2Cerebral aneurysm (HP:0004944)3.67038234
3Exercise-induced myalgia (HP:0003738)3.56530416
4Increased connective tissue (HP:0009025)3.56469450
5Hyporeflexia of lower limbs (HP:0002600)3.55498872
6Myoglobinuria (HP:0002913)3.52075250
7Type 1 muscle fiber predominance (HP:0003803)3.35791750
8Difficulty running (HP:0009046)3.29004906
9Protrusio acetabuli (HP:0003179)3.26759665
10Aortic aneurysm (HP:0004942)3.01852509
11Asymmetric septal hypertrophy (HP:0001670)2.97013406
12Muscle fiber splitting (HP:0003555)2.94309888
13Abnormality of the fingertips (HP:0001211)2.91917295
14Muscle fiber inclusion bodies (HP:0100299)2.84161057
15Broad metatarsal (HP:0001783)2.83854889
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83137074
17Sudden death (HP:0001699)2.82583501
18Hematochezia (HP:0002573)2.81977218
19Subaortic stenosis (HP:0001682)2.78938261
20Abnormality of the left ventricular outflow tract (HP:0011103)2.78938261
21Gastrointestinal stroma tumor (HP:0100723)2.66779230
22Aneurysm (HP:0002617)2.64816339
23Ventricular tachycardia (HP:0004756)2.64316766
24Abnormality of skeletal muscle fiber size (HP:0012084)2.57740650
25Colitis (HP:0002583)2.57586195
26Facial diplegia (HP:0001349)2.55775810
27Shallow orbits (HP:0000586)2.55484529
28Lymphangioma (HP:0100764)2.54974582
29Rhabdomyolysis (HP:0003201)2.54067655
30Mitral valve prolapse (HP:0001634)2.53260998
31Calf muscle hypertrophy (HP:0008981)2.53130133
32Right ventricular cardiomyopathy (HP:0011663)2.52590429
33EMG: myopathic abnormalities (HP:0003458)2.48366117
34Frequent falls (HP:0002359)2.46780221
35Ankle contracture (HP:0006466)2.43569397
36Vascular tortuosity (HP:0004948)2.42167325
37Ulnar deviation of the wrist (HP:0003049)2.41872215
38Persistence of primary teeth (HP:0006335)2.39804582
39Emphysema (HP:0002097)2.38739810
40Increased variability in muscle fiber diameter (HP:0003557)2.38406566
41Nemaline bodies (HP:0003798)2.37326348
42Spontaneous hematomas (HP:0007420)2.37319981
43Aortic dissection (HP:0002647)2.35486696
44Hyperacusis (HP:0010780)2.35037167
45Muscle hypertrophy of the lower extremities (HP:0008968)2.33788561
46Deep venous thrombosis (HP:0002625)2.33384056
47Lipoatrophy (HP:0100578)2.27861146
48Abnormality of the calf musculature (HP:0001430)2.27775705
49Difficulty climbing stairs (HP:0003551)2.22035316
50Arterial tortuosity (HP:0005116)2.21963167
51Scapular winging (HP:0003691)2.20267127
52Agammaglobulinemia (HP:0004432)2.18602591
53Premature rupture of membranes (HP:0001788)2.13762776
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.10925568
55Increased density of long bones (HP:0006392)2.10900431
56Dislocated radial head (HP:0003083)2.10311712
57Complement deficiency (HP:0004431)2.08419260
58Myocardial infarction (HP:0001658)2.08376434
59Turricephaly (HP:0000262)2.08242862
60Striae distensae (HP:0001065)2.07144331
61Hypoplastic ischia (HP:0003175)2.05883191
62Gastrointestinal inflammation (HP:0004386)2.05725284
63Obstructive sleep apnea (HP:0002870)2.04574456
64Limb-girdle muscle atrophy (HP:0003797)2.04226907
65Broad face (HP:0000283)2.04073872
66Long toe (HP:0010511)2.03003842
67Rectal prolapse (HP:0002035)2.01537960
68Hypoglycemic coma (HP:0001325)2.00988228
69Cervical subluxation (HP:0003308)2.00375536
70Inflammation of the large intestine (HP:0002037)1.97994663
71Enlarged penis (HP:0000040)1.97779824
72Upper limb amyotrophy (HP:0009129)1.97467608
73Distal upper limb amyotrophy (HP:0007149)1.97467608
74Round ear (HP:0100830)1.96544649
75Abnormality of the calcaneus (HP:0008364)1.96041604
76Macroorchidism (HP:0000053)1.95697961
77Osteolytic defects of the phalanges of the hand (HP:0009771)1.93541007
78Osteolytic defects of the hand bones (HP:0009699)1.93541007
79Abnormality of the 4th metacarpal (HP:0010012)1.92994843
80Chronic mucocutaneous candidiasis (HP:0002728)1.92922746
81Recurrent cutaneous fungal infections (HP:0011370)1.92922746
82Metaphyseal cupping (HP:0003021)1.92153897
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91771194
84Spondylolisthesis (HP:0003302)1.89562235
85Peritonitis (HP:0002586)1.89344261
86Abnormality of the radial head (HP:0003995)1.89087908
87Distal arthrogryposis (HP:0005684)1.88721311
88Dilated cardiomyopathy (HP:0001644)1.88561773
89Polycythemia (HP:0001901)1.88359879
90Overgrowth (HP:0001548)1.87286989
91Muscle stiffness (HP:0003552)1.87138275
92Distal lower limb amyotrophy (HP:0008944)1.85845840
93Bladder diverticulum (HP:0000015)1.85146346
94Atrial fibrillation (HP:0005110)1.84569551
95Ovoid vertebral bodies (HP:0003300)1.83997441
96Hypoalphalipoproteinemia (HP:0003233)1.83214376
97Ulnar bowing (HP:0003031)1.82944079
98Dilatation of the ascending aorta (HP:0005111)1.82488219
99Mildly elevated creatine phosphokinase (HP:0008180)1.81901222
100Cellulitis (HP:0100658)1.80995880
101Abnormality of the ischium (HP:0003174)1.80323885
102Bundle branch block (HP:0011710)1.78213612
103Neonatal hypoglycemia (HP:0001998)1.77410668
104Skin nodule (HP:0200036)1.77271853
105Disproportionate tall stature (HP:0001519)1.76898966
106Subacute progressive viral hepatitis (HP:0006572)1.76421345
107Abnormality of the peritoneum (HP:0002585)1.76259670
108Back pain (HP:0003418)1.76214275
109Biconcave vertebral bodies (HP:0004586)1.76087427
110Flat acetabular roof (HP:0003180)1.74711539
111Camptodactyly of toe (HP:0001836)1.74568488
112Mitral regurgitation (HP:0001653)1.74124401
113Hand muscle atrophy (HP:0009130)1.73527259
114Myopathic facies (HP:0002058)1.72398228
115Wormian bones (HP:0002645)1.71281788
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.70188078
117Dysmetric saccades (HP:0000641)1.69945232
118Abnormality of the thoracic spine (HP:0100711)1.69934298
119Bicuspid aortic valve (HP:0001647)1.69643094
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69370972
121Short 4th metacarpal (HP:0010044)1.69370972
122Cupped ribs (HP:0000887)1.68899738
123Joint laxity (HP:0001388)1.67318547
124Renovascular hypertension (HP:0100817)1.66429791
125Coxa vara (HP:0002812)1.66410487
126Primary atrial arrhythmia (HP:0001692)1.66012442
127Asymmetry of the thorax (HP:0001555)1.65117767
128Eczematoid dermatitis (HP:0000976)1.64940766
129Spinal rigidity (HP:0003306)1.64807751
130Esophageal varix (HP:0002040)1.64628474
131Calcaneovalgus deformity (HP:0001848)1.64340498
132Ketoacidosis (HP:0001993)1.62660844
133Neoplasm of the heart (HP:0100544)1.62580674
134Broad palm (HP:0001169)1.62338119
135Hyperkalemia (HP:0002153)1.61377447
136Long eyelashes (HP:0000527)1.61162418
137Hamartoma of the eye (HP:0010568)1.60887726
138Abnormality of complement system (HP:0005339)1.60809740
139Atrioventricular block (HP:0001678)1.60227338
140Xanthomatosis (HP:0000991)1.60200122
141Distal lower limb muscle weakness (HP:0009053)1.59735638
142Mitral stenosis (HP:0001718)1.59653186
143Thin bony cortex (HP:0002753)1.59319122
144Hemorrhage of the eye (HP:0011885)1.59305551
145Conjunctival hamartoma (HP:0100780)1.59193457
146Thoracic kyphosis (HP:0002942)1.59184565
147Abnormality of the right ventricle (HP:0001707)1.59052586
148Slender build (HP:0001533)1.58358079
149Metatarsus adductus (HP:0001840)1.58039206
150Narrow palate (HP:0000189)1.55309806
151Wide anterior fontanel (HP:0000260)1.53584661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.27388232
2PKN24.45101410
3TTN4.23971357
4PRPF4B2.82569197
5ERN12.72250519
6EEF2K2.39354397
7SMG12.36600292
8MAP3K102.33075094
9SIK12.20156065
10MAP3K132.15124802
11RIPK12.09810558
12PTK62.06608417
13PDGFRA1.94714334
14LATS11.77634245
15TGFBR21.62875302
16CDC42BPA1.61182883
17PDK21.54746359
18CAMK1D1.51988176
19MAP2K31.48504611
20LRRK21.46931212
21DMPK1.41582666
22PDK31.40102320
23PDK41.40102320
24FGFR41.39914273
25OBSCN1.39414082
26PNCK1.38585569
27MAP4K11.36947266
28CDK121.35971867
29CAMK1G1.34754638
30CDK61.31587650
31LMTK21.31423005
32JAK11.30703219
33FLT31.28955647
34MAP3K71.23424939
35MAPK71.19415299
36FGFR31.18566952
37TYK21.18253994
38PHKG11.17439221
39PHKG21.17439221
40PRKD21.13888558
41BLK1.13648412
42EPHB11.12352370
43BCKDK1.10140258
44MTOR1.05210709
45NLK1.04863918
46MARK21.03159987
47BRD41.00586491
48MELK1.00335681
49PAK41.00040595
50RIPK40.97516912
51TIE10.97406522
52ICK0.95668485
53MAP3K140.92244608
54BMX0.90640203
55MAP2K20.88010570
56KSR20.86409635
57PDGFRB0.85660662
58EPHA30.85145763
59TNK20.85136480
60STK30.84984472
61PAK20.84507923
62DDR20.84109438
63SGK30.82721896
64AKT30.82092879
65ZAP700.81501307
66NEK10.81205659
67ILK0.80394174
68SCYL20.80020645
69JAK30.79392837
70PASK0.78398988
71RET0.78318722
72PRKCH0.78311170
73CAMKK10.78213104
74JAK20.76924677
75HIPK20.75725004
76TBK10.75555595
77SGK20.74910203
78* NEK90.74539554
79STK380.74001031
80TGFBR10.73363997
81CDK40.72112505
82PRKAA20.72027980
83MAP3K60.71611913
84MYLK0.69782982
85PRKD10.69064483
86STK100.68853067
87RPS6KA40.68744772
88MAP2K10.68235961
89SIK20.68129897
90SYK0.67110424
91STK240.63743545
92MAP3K30.62873382
93STK40.61738609
94PTK20.60879817
95CAMK40.59049494
96FGFR10.58164335
97PAK30.58157772
98PTK2B0.57643491
99TRPM70.57519326
100CSF1R0.55809666
101CSK0.55625346
102FGFR20.55511124
103MAPK120.55435889
104PDK10.55306742
105CDK90.54555847
106MAP3K10.54081515
107ALK0.54050430
108KIT0.52928922
109PDPK10.52515896
110PIK3CG0.52275117
111PRKD30.51645546
112ERBB30.49058128
113RPS6KA20.47900754
114KDR0.47473192
115HCK0.47085802
116FES0.45834500
117MAPK110.44635456
118PIK3CA0.43646177
119PRKAA10.43574775
120DYRK1B0.43402631
121GSK3A0.43384577
122TAOK30.43235635
123SGK2230.42940555
124SGK4940.42940555
125WNK10.42370972
126CHUK0.41499737
127NEK20.41107968
128IRAK40.41101177
129RPS6KL10.41040902
130RPS6KC10.41040902
131MAPK30.41020216
132FGR0.40891911
133RPS6KA60.40719682
134ITK0.39925796
135MET0.38802541
136BTK0.38540299
137LATS20.38488538
138EGFR0.36546409

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80084073
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52154267
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32974712
4Fatty acid degradation_Homo sapiens_hsa000712.31267490
5Nitrogen metabolism_Homo sapiens_hsa009102.08512151
6Propanoate metabolism_Homo sapiens_hsa006401.97902563
7Lysine degradation_Homo sapiens_hsa003101.79330464
8Insulin resistance_Homo sapiens_hsa049311.75135553
9Dilated cardiomyopathy_Homo sapiens_hsa054141.73204205
10PPAR signaling pathway_Homo sapiens_hsa033201.70253256
11Fatty acid metabolism_Homo sapiens_hsa012121.69981337
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68621945
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63142560
14Chronic myeloid leukemia_Homo sapiens_hsa052201.54783866
15Focal adhesion_Homo sapiens_hsa045101.51504917
16Staphylococcus aureus infection_Homo sapiens_hsa051501.49178889
17Carbon metabolism_Homo sapiens_hsa012001.46025878
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.43388766
19Viral myocarditis_Homo sapiens_hsa054161.39763671
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30373702
21Arginine biosynthesis_Homo sapiens_hsa002201.26927762
22ECM-receptor interaction_Homo sapiens_hsa045121.26661231
23Proteoglycans in cancer_Homo sapiens_hsa052051.23061582
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.21422566
25Primary immunodeficiency_Homo sapiens_hsa053401.20048305
26Other glycan degradation_Homo sapiens_hsa005111.19312697
27Insulin signaling pathway_Homo sapiens_hsa049101.18953092
28Starch and sucrose metabolism_Homo sapiens_hsa005001.18626137
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17740035
30Complement and coagulation cascades_Homo sapiens_hsa046101.16673145
31Small cell lung cancer_Homo sapiens_hsa052221.16014637
32Tryptophan metabolism_Homo sapiens_hsa003801.14367417
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13769950
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11563890
35Platelet activation_Homo sapiens_hsa046111.10673806
36Choline metabolism in cancer_Homo sapiens_hsa052311.10421512
37AMPK signaling pathway_Homo sapiens_hsa041521.10032143
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.10009900
39mTOR signaling pathway_Homo sapiens_hsa041501.08681979
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07833586
41Adherens junction_Homo sapiens_hsa045201.07624666
42B cell receptor signaling pathway_Homo sapiens_hsa046621.04932072
43Osteoclast differentiation_Homo sapiens_hsa043801.04314439
44Toxoplasmosis_Homo sapiens_hsa051451.04296269
45Glucagon signaling pathway_Homo sapiens_hsa049221.03764372
46Amoebiasis_Homo sapiens_hsa051461.01814722
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.00688007
48GnRH signaling pathway_Homo sapiens_hsa049121.00657345
49T cell receptor signaling pathway_Homo sapiens_hsa046600.97445209
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.96541443
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96538867
52Pancreatic cancer_Homo sapiens_hsa052120.95227276
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94429110
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.93969452
55Pyruvate metabolism_Homo sapiens_hsa006200.91939735
56Histidine metabolism_Homo sapiens_hsa003400.91680072
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91644907
58Acute myeloid leukemia_Homo sapiens_hsa052210.91166669
59Non-small cell lung cancer_Homo sapiens_hsa052230.90608215
60Caffeine metabolism_Homo sapiens_hsa002320.88075267
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.86603688
62Inositol phosphate metabolism_Homo sapiens_hsa005620.83998711
63Influenza A_Homo sapiens_hsa051640.83642372
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83136290
65Measles_Homo sapiens_hsa051620.82594300
66Leishmaniasis_Homo sapiens_hsa051400.82488406
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.82220951
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81298293
69HIF-1 signaling pathway_Homo sapiens_hsa040660.80350464
70Type II diabetes mellitus_Homo sapiens_hsa049300.80306164
71Autoimmune thyroid disease_Homo sapiens_hsa053200.78766686
72Estrogen signaling pathway_Homo sapiens_hsa049150.78370183
73Biosynthesis of amino acids_Homo sapiens_hsa012300.78017225
74Colorectal cancer_Homo sapiens_hsa052100.77731974
75Bile secretion_Homo sapiens_hsa049760.76013873
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.75695095
77Fatty acid biosynthesis_Homo sapiens_hsa000610.75190093
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74884107
79Endometrial cancer_Homo sapiens_hsa052130.73807500
80Hepatitis C_Homo sapiens_hsa051600.71781837
81Lysosome_Homo sapiens_hsa041420.70747067
82Basal cell carcinoma_Homo sapiens_hsa052170.70454011
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70058180
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69484796
85VEGF signaling pathway_Homo sapiens_hsa043700.69364023
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68298148
87Allograft rejection_Homo sapiens_hsa053300.68108460
88Renal cell carcinoma_Homo sapiens_hsa052110.67478055
89MAPK signaling pathway_Homo sapiens_hsa040100.66589861
90MicroRNAs in cancer_Homo sapiens_hsa052060.65757784
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.65109820
92Oxytocin signaling pathway_Homo sapiens_hsa049210.64794317
93Dorso-ventral axis formation_Homo sapiens_hsa043200.64156047
94Pathways in cancer_Homo sapiens_hsa052000.63709035
95beta-Alanine metabolism_Homo sapiens_hsa004100.63559252
96ErbB signaling pathway_Homo sapiens_hsa040120.63195624
97FoxO signaling pathway_Homo sapiens_hsa040680.63117383
98Graft-versus-host disease_Homo sapiens_hsa053320.63063121
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62060258
100Bladder cancer_Homo sapiens_hsa052190.60558113
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60294399
102Notch signaling pathway_Homo sapiens_hsa043300.59774566
103Glioma_Homo sapiens_hsa052140.59431726
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59115126
105Apoptosis_Homo sapiens_hsa042100.58655785
106Butanoate metabolism_Homo sapiens_hsa006500.58546977
107ABC transporters_Homo sapiens_hsa020100.58512754
108TNF signaling pathway_Homo sapiens_hsa046680.57709082
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57397298
110Prolactin signaling pathway_Homo sapiens_hsa049170.57201806
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56884304
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56820412
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56270269
114Thyroid cancer_Homo sapiens_hsa052160.55181869
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55058927
116Hedgehog signaling pathway_Homo sapiens_hsa043400.54405958
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54310886
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53994602
119Hematopoietic cell lineage_Homo sapiens_hsa046400.53939519
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.53877616
121Herpes simplex infection_Homo sapiens_hsa051680.52403330
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50850491
123Fat digestion and absorption_Homo sapiens_hsa049750.50296204
124Glycerolipid metabolism_Homo sapiens_hsa005610.49166468
125Prostate cancer_Homo sapiens_hsa052150.49108910
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48322864
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.47932602
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47513771
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47393286
130Protein digestion and absorption_Homo sapiens_hsa049740.46655000
131Hepatitis B_Homo sapiens_hsa051610.46448080
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46148032
133HTLV-I infection_Homo sapiens_hsa051660.45271886
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45065736
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44743085

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