NEK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.72274746
2ribosomal small subunit assembly (GO:0000028)5.24440849
3viral transcription (GO:0019083)5.15776618
4formation of translation preinitiation complex (GO:0001731)5.11174835
5translational termination (GO:0006415)5.09807594
6synapsis (GO:0007129)4.98436740
7ribosomal small subunit biogenesis (GO:0042274)4.96697636
8purine nucleobase biosynthetic process (GO:0009113)4.63246384
9translational elongation (GO:0006414)4.50922311
10nucleobase biosynthetic process (GO:0046112)4.37946393
11translational initiation (GO:0006413)4.33808255
12ribosomal large subunit biogenesis (GO:0042273)4.30180346
13cellular protein complex disassembly (GO:0043624)4.22181670
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.16779719
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.14795035
16protein neddylation (GO:0045116)4.13146587
17viral life cycle (GO:0019058)4.10065897
18cotranslational protein targeting to membrane (GO:0006613)4.07233215
19protein targeting to ER (GO:0045047)4.01361816
20cullin deneddylation (GO:0010388)3.83454629
21protein localization to endoplasmic reticulum (GO:0070972)3.79289644
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78670654
23DNA double-strand break processing (GO:0000729)3.78386708
24protein complex disassembly (GO:0043241)3.76152856
25rRNA modification (GO:0000154)3.70158139
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.69963560
27ribonucleoprotein complex biogenesis (GO:0022613)3.69576377
28regulation of mitotic spindle checkpoint (GO:1903504)3.60883773
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60883773
30macromolecular complex disassembly (GO:0032984)3.59746984
31protein deneddylation (GO:0000338)3.59174702
32histone H2A acetylation (GO:0043968)3.59014295
33DNA strand elongation involved in DNA replication (GO:0006271)3.56643597
34resolution of meiotic recombination intermediates (GO:0000712)3.53559194
35ribosome assembly (GO:0042255)3.52943632
36double-strand break repair via nonhomologous end joining (GO:0006303)3.48282733
37non-recombinational repair (GO:0000726)3.48282733
38mitotic metaphase plate congression (GO:0007080)3.46762776
39metaphase plate congression (GO:0051310)3.44099852
40CENP-A containing nucleosome assembly (GO:0034080)3.43587709
41chromatin remodeling at centromere (GO:0031055)3.43127703
42chaperone-mediated protein transport (GO:0072321)3.40266609
43protein localization to kinetochore (GO:0034501)3.39291890
44DNA replication initiation (GO:0006270)3.38002791
45DNA strand elongation (GO:0022616)3.35959851
46DNA unwinding involved in DNA replication (GO:0006268)3.34321213
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.32779883
48intraciliary transport (GO:0042073)3.32004975
49establishment of integrated proviral latency (GO:0075713)3.31365850
50mitotic sister chromatid cohesion (GO:0007064)3.29706912
51rRNA processing (GO:0006364)3.29089429
52DNA replication-dependent nucleosome assembly (GO:0006335)3.28831790
53DNA replication-dependent nucleosome organization (GO:0034723)3.28831790
54intra-S DNA damage checkpoint (GO:0031573)3.27278951
55rRNA methylation (GO:0031167)3.26852509
56DNA ligation (GO:0006266)3.25753686
57IMP biosynthetic process (GO:0006188)3.24499298
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.23419018
59termination of RNA polymerase III transcription (GO:0006386)3.23419018
60spliceosomal complex assembly (GO:0000245)3.23394180
61translation (GO:0006412)3.21679640
62telomere maintenance via semi-conservative replication (GO:0032201)3.21669931
63nuclear-transcribed mRNA catabolic process (GO:0000956)3.19763976
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17062974
65replication fork processing (GO:0031297)3.15402653
66rRNA metabolic process (GO:0016072)3.14788487
67negative regulation of DNA recombination (GO:0045910)3.13938735
68regulation of helicase activity (GO:0051095)3.13053791
69viral mRNA export from host cell nucleus (GO:0046784)3.12631036
70spliceosomal snRNP assembly (GO:0000387)3.12181967
71folic acid-containing compound biosynthetic process (GO:0009396)3.11542589
72mitotic G2/M transition checkpoint (GO:0044818)3.11206330
73establishment of chromosome localization (GO:0051303)3.10385966
74proteasome assembly (GO:0043248)3.09633038
75regulation of non-canonical Wnt signaling pathway (GO:2000050)3.09203841
76mitotic recombination (GO:0006312)3.06200481
77ribosome biogenesis (GO:0042254)3.03930415
78telomere maintenance via recombination (GO:0000722)3.03532207
79mRNA catabolic process (GO:0006402)3.01951129
80spindle checkpoint (GO:0031577)3.01815700
81single strand break repair (GO:0000012)3.01130029
82mismatch repair (GO:0006298)3.00742737
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.99231173
84respiratory chain complex IV assembly (GO:0008535)2.98865476
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97820102
86mitotic spindle checkpoint (GO:0071174)2.97662367
87cellular component biogenesis (GO:0044085)2.97194119
88mitotic chromosome condensation (GO:0007076)2.96992489
89DNA catabolic process, exonucleolytic (GO:0000738)2.94476830
90reciprocal DNA recombination (GO:0035825)2.94095815
91reciprocal meiotic recombination (GO:0007131)2.94095815
92DNA damage response, detection of DNA damage (GO:0042769)2.91843925
93DNA replication-independent nucleosome organization (GO:0034724)2.91420686
94DNA replication-independent nucleosome assembly (GO:0006336)2.91420686
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91128262
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90821714
97RNA catabolic process (GO:0006401)2.90489350
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90259339
99regulation of mitochondrial translation (GO:0070129)2.88441078
100cytochrome complex assembly (GO:0017004)2.88275567
101lysine catabolic process (GO:0006554)2.87955978
102lysine metabolic process (GO:0006553)2.87955978
103sulfation (GO:0051923)2.87551522
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.87078499
105negative regulation of sister chromatid segregation (GO:0033046)2.87078499
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87078499
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87078499
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87078499
109telomere maintenance via telomere lengthening (GO:0010833)2.87007874
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86522945
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86498650
112regulation of meiosis I (GO:0060631)2.85051226
113histone exchange (GO:0043486)2.84751163
114regulation of centriole replication (GO:0046599)2.84265548
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84019896
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.84019896
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82799579
118negative regulation of striated muscle cell apoptotic process (GO:0010664)2.82717810
119histone mRNA metabolic process (GO:0008334)2.82348070
120establishment of viral latency (GO:0019043)2.81507694
121attachment of spindle microtubules to kinetochore (GO:0008608)2.81232971
122kinetochore organization (GO:0051383)2.81218489
123protein localization to chromosome, centromeric region (GO:0071459)2.80497958
124branched-chain amino acid catabolic process (GO:0009083)2.78378931
125regulation of sister chromatid cohesion (GO:0007063)2.77915684
126somite rostral/caudal axis specification (GO:0032525)2.76166633
127negative regulation of ligase activity (GO:0051352)2.75273171
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75273171
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74341896
130mitochondrial respiratory chain complex assembly (GO:0033108)2.74194279
131blastocyst development (GO:0001824)2.74024941
132centriole replication (GO:0007099)2.73854576
133recombinational repair (GO:0000725)2.73789670
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73653017
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73653017
136protein complex biogenesis (GO:0070271)2.72514103
137double-strand break repair via homologous recombination (GO:0000724)2.72402271
138mitotic nuclear envelope disassembly (GO:0007077)2.69489308
139DNA replication checkpoint (GO:0000076)2.69186678
140kinetochore assembly (GO:0051382)2.68906168
141negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68816850
142nonmotile primary cilium assembly (GO:0035058)2.68743352
143mitotic spindle assembly checkpoint (GO:0007094)2.68298013
144positive regulation of chromosome segregation (GO:0051984)2.68225850
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67775972
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67775972
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.65548928
148mitotic G2 DNA damage checkpoint (GO:0007095)2.65161072
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.65159270
150NADH dehydrogenase complex assembly (GO:0010257)2.65159270
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65159270
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64974169
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64974169
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64974169
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.64824684
156mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64353307
157regulation of mitotic sister chromatid segregation (GO:0033047)2.64242494
158regulation of sister chromatid segregation (GO:0033045)2.64242494
159regulation of mitotic sister chromatid separation (GO:0010965)2.64242494
160signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64049638
161signal transduction involved in DNA damage checkpoint (GO:0072422)2.64049638
162regulation of DNA endoreduplication (GO:0032875)2.63773144
163negative regulation of chromosome segregation (GO:0051985)2.63737314
164IMP metabolic process (GO:0046040)2.63073046
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61807989
166piRNA metabolic process (GO:0034587)2.59041092
167male meiosis (GO:0007140)2.58875687
168sister chromatid cohesion (GO:0007062)2.58451598
169protein prenylation (GO:0018342)2.58308293
170prenylation (GO:0097354)2.58308293
171spindle assembly checkpoint (GO:0071173)2.56839948
172somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56330086
173isotype switching (GO:0045190)2.56330086
174somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56330086
175regulation of cilium movement (GO:0003352)2.55939939

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57370724
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34198535
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64940443
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44250874
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13803753
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.08611679
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.06185004
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06128552
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90534503
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86980544
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86606030
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86404914
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82695538
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79336089
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.77911627
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75231352
17ZNF274_21170338_ChIP-Seq_K562_Hela2.72080444
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.70210732
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52360675
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51738104
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38421426
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34966572
23VDR_22108803_ChIP-Seq_LS180_Human2.34195481
24XRN2_22483619_ChIP-Seq_HELA_Human2.34183427
25FUS_26573619_Chip-Seq_HEK293_Human2.31792147
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30079672
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29876307
28EWS_26573619_Chip-Seq_HEK293_Human2.29827096
29VDR_23849224_ChIP-Seq_CD4+_Human2.29286267
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26618128
31IGF1R_20145208_ChIP-Seq_DFB_Human2.26133405
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.22697184
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12710015
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11617527
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11477390
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11420960
37FOXP3_21729870_ChIP-Seq_TREG_Human2.09365920
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04708068
39ELK1_19687146_ChIP-ChIP_HELA_Human2.00783008
40TTF2_22483619_ChIP-Seq_HELA_Human1.96334896
41DCP1A_22483619_ChIP-Seq_HELA_Human1.92195661
42GABP_19822575_ChIP-Seq_HepG2_Human1.90630858
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88747269
44P300_19829295_ChIP-Seq_ESCs_Human1.88411976
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85448217
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.83569039
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81739128
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81258152
49TAF15_26573619_Chip-Seq_HEK293_Human1.80608873
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77933259
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77291620
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76638294
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70908329
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70055695
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66649627
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66261136
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62854312
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61054904
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59559434
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58819840
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58664393
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58529039
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57773072
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54969689
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53968311
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.50674533
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50064601
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49785715
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48332045
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47425240
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46641434
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.43888990
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43412553
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.42475579
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.40096584
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39765448
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39453551
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.36795748
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36382126
80CIITA_25753668_ChIP-Seq_RAJI_Human1.35525268
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35422048
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34576620
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33455604
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33329673
85KDM5A_27292631_Chip-Seq_BREAST_Human1.30845162
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30841052
87AR_21909140_ChIP-Seq_LNCAP_Human1.30101929
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29995424
89* NANOG_21062744_ChIP-ChIP_HESCs_Human1.28790692
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28406851
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28043782
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.27991893
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26907417
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26229224
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24732748
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.22986831
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.21618211
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20868139
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.20170457
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19661190
101TCF4_22108803_ChIP-Seq_LS180_Human1.18175585
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16395351
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16395351
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16395351
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15085333
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14466545
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13147716
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12845610
109TFEB_21752829_ChIP-Seq_HELA_Human1.12006140
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11105125
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10940683
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.10737408
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10593958
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09832540
115* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09480508
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09308465
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09205115
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08948088
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08370013
120ER_23166858_ChIP-Seq_MCF-7_Human1.08146639
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07871707
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07803961
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07689815
124* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06021433
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05594705
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04724790
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.04497204
128* SOX2_19829295_ChIP-Seq_ESCs_Human1.03635714
129* NANOG_19829295_ChIP-Seq_ESCs_Human1.03635714
130GBX2_23144817_ChIP-Seq_PC3_Human1.03188615
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02640313
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02466802
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.01824704
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01799900
135CBP_20019798_ChIP-Seq_JUKART_Human1.01799900
136SOX17_20123909_ChIP-Seq_XEN_Mouse1.01685505
137* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99967886
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99946519
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98981147
140RNF2_27304074_Chip-Seq_NSC_Mouse0.98868321
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98514446
142MYC_18940864_ChIP-ChIP_HL60_Human0.97783954
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97094989
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96578048
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.96231090
146P300_18555785_Chip-Seq_ESCs_Mouse0.95545085
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95194870
148AR_25329375_ChIP-Seq_VCAP_Human0.95086171
149BCAT_22108803_ChIP-Seq_LS180_Human0.94805245
150SMAD4_21799915_ChIP-Seq_A2780_Human0.94238219
151POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93548289
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93196300
153RUNX2_22187159_ChIP-Seq_PCA_Human0.93086932
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91972212
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91943171
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88810090
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88363097
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88144123
159NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84147734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41118810
2MP0004957_abnormal_blastocyst_morpholog3.58585821
3MP0010094_abnormal_chromosome_stability3.49235421
4MP0008877_abnormal_DNA_methylation3.48922704
5MP0003806_abnormal_nucleotide_metabolis3.17931772
6MP0003077_abnormal_cell_cycle3.15764312
7MP0003111_abnormal_nucleus_morphology2.97558030
8MP0005084_abnormal_gallbladder_morpholo2.90188775
9MP0010030_abnormal_orbit_morphology2.83086102
10MP0003195_calcinosis2.73538953
11MP0008058_abnormal_DNA_repair2.70171305
12MP0008932_abnormal_embryonic_tissue2.63775075
13MP0002396_abnormal_hematopoietic_system2.49874554
14MP0006054_spinal_hemorrhage2.39808810
15MP0002138_abnormal_hepatobiliary_system2.32368765
16MP0002139_abnormal_hepatobiliary_system2.31759678
17MP0001730_embryonic_growth_arrest2.21086490
18MP0009697_abnormal_copulation2.19372600
19MP0002638_abnormal_pupillary_reflex2.05863677
20MP0008007_abnormal_cellular_replicative2.05397356
21MP0004133_heterotaxia1.95877329
22MP0002102_abnormal_ear_morphology1.89595146
23MP0003718_maternal_effect1.86670589
24MP0008789_abnormal_olfactory_epithelium1.82991939
25MP0001293_anophthalmia1.78282242
26MP0003567_abnormal_fetal_cardiomyocyte1.77902706
27MP0000350_abnormal_cell_proliferation1.77811690
28MP0000372_irregular_coat_pigmentation1.76697551
29MP0004084_abnormal_cardiac_muscle1.75505812
30MP0003786_premature_aging1.71312402
31MP0003890_abnormal_embryonic-extraembry1.70785930
32MP0005408_hypopigmentation1.70715405
33MP0010368_abnormal_lymphatic_system1.70281047
34MP0002938_white_spotting1.70201512
35MP0001697_abnormal_embryo_size1.63491271
36MP0006072_abnormal_retinal_apoptosis1.62743429
37MP0005380_embryogenesis_phenotype1.60813979
38MP0001672_abnormal_embryogenesis/_devel1.60813979
39MP0009379_abnormal_foot_pigmentation1.59025351
40MP0003941_abnormal_skin_development1.58123945
41MP0003315_abnormal_perineum_morphology1.55448959
42MP0003787_abnormal_imprinting1.54096176
43MP0002653_abnormal_ependyma_morphology1.49366099
44MP0000516_abnormal_urinary_system1.48915503
45MP0005367_renal/urinary_system_phenotyp1.48915503
46MP0003121_genomic_imprinting1.48442490
47MP0010234_abnormal_vibrissa_follicle1.47957206
48MP0002210_abnormal_sex_determination1.43260935
49MP0002080_prenatal_lethality1.42403275
50MP0010352_gastrointestinal_tract_polyps1.40561935
51MP0005075_abnormal_melanosome_morpholog1.39107678
52MP0003984_embryonic_growth_retardation1.37065881
53MP0006292_abnormal_olfactory_placode1.34739451
54MP0002084_abnormal_developmental_patter1.34129757
55MP0002085_abnormal_embryonic_tissue1.33524928
56MP0002088_abnormal_embryonic_growth/wei1.33433017
57MP0005551_abnormal_eye_electrophysiolog1.29575511
58MP0000313_abnormal_cell_death1.29461448
59MP0002837_dystrophic_cardiac_calcinosis1.26008679
60MP0002132_abnormal_respiratory_system1.24529891
61MP0001529_abnormal_vocalization1.23653014
62MP0002086_abnormal_extraembryonic_tissu1.22968312
63MP0003123_paternal_imprinting1.21020505
64MP0001188_hyperpigmentation1.20120835
65MP0003183_abnormal_peptide_metabolism1.18806098
66MP0004147_increased_porphyrin_level1.18754705
67MP0003136_yellow_coat_color1.18268541
68MP0003950_abnormal_plasma_membrane1.15855706
69MP0001145_abnormal_male_reproductive1.15513780
70MP0008995_early_reproductive_senescence1.14465423
71MP0005253_abnormal_eye_physiology1.13585331
72MP0003878_abnormal_ear_physiology1.12082489
73MP0005377_hearing/vestibular/ear_phenot1.12082489
74MP0001764_abnormal_homeostasis1.11955809
75MP0002160_abnormal_reproductive_system1.10345514
76MP0005395_other_phenotype1.07199008
77MP0000490_abnormal_crypts_of1.05766771
78MP0005499_abnormal_olfactory_system1.03910491
79MP0005394_taste/olfaction_phenotype1.03910491
80MP0005085_abnormal_gallbladder_physiolo1.02666698
81MP0003763_abnormal_thymus_physiology1.02142962
82MP0001485_abnormal_pinna_reflex1.01877062
83MP0003880_abnormal_central_pattern1.01334608
84MP0001324_abnormal_eye_pigmentation1.01333274
85MP0004197_abnormal_fetal_growth/weight/1.00228645
86MP0000653_abnormal_sex_gland0.99476041
87MP0009672_abnormal_birth_weight0.99407027
88MP0003698_abnormal_male_reproductive0.99234931
89MP0002233_abnormal_nose_morphology0.96242352
90MP0001929_abnormal_gametogenesis0.95862712
91MP0002092_abnormal_eye_morphology0.94841907
92MP0002751_abnormal_autonomic_nervous0.94181750
93MP0002019_abnormal_tumor_incidence0.94017700
94MP0000566_synostosis0.93987830
95MP0009333_abnormal_splenocyte_physiolog0.93966789
96MP0002090_abnormal_vision0.92954829
97MP0004215_abnormal_myocardial_fiber0.92468815
98MP0005391_vision/eye_phenotype0.91335418
99MP0002111_abnormal_tail_morphology0.89864826
100MP0000049_abnormal_middle_ear0.89071567
101MP0000647_abnormal_sebaceous_gland0.88677334
102MP0002254_reproductive_system_inflammat0.88311574
103MP0009384_cardiac_valve_regurgitation0.87661627
104MP0001286_abnormal_eye_development0.87252637
105MP0006036_abnormal_mitochondrial_physio0.87193609
106MP0001986_abnormal_taste_sensitivity0.86890105
107MP0005023_abnormal_wound_healing0.86476390
108MP0002697_abnormal_eye_size0.86344423
109MP0000703_abnormal_thymus_morphology0.83435051
110MP0009703_decreased_birth_body0.82444576
111MP0003221_abnormal_cardiomyocyte_apopto0.82062833
112MP0002277_abnormal_respiratory_mucosa0.81452736
113MP0004885_abnormal_endolymph0.81089419
114MP0005365_abnormal_bile_salt0.81076006
115MP0003938_abnormal_ear_development0.80574822
116MP0000534_abnormal_ureter_morphology0.79907098
117MP0005187_abnormal_penis_morphology0.79784197
118MP0000631_abnormal_neuroendocrine_gland0.79631556
119MP0003122_maternal_imprinting0.79483025
120MP0003011_delayed_dark_adaptation0.79334710
121MP0010307_abnormal_tumor_latency0.78935110
122MP0003119_abnormal_digestive_system0.77800106
123MP0001879_abnormal_lymphatic_vessel0.77763096
124MP0005195_abnormal_posterior_eye0.75747584
125MP0002127_abnormal_cardiovascular_syste0.75282952
126MP0004019_abnormal_vitamin_homeostasis0.75277898
127MP0005389_reproductive_system_phenotype0.75086996
128MP0003656_abnormal_erythrocyte_physiolo0.73743494
129MP0005410_abnormal_fertilization0.73401781
130MP0000689_abnormal_spleen_morphology0.73383100
131MP0002722_abnormal_immune_system0.73098310
132MP0001984_abnormal_olfaction0.73008151
133MP0001119_abnormal_female_reproductive0.72761994
134MP0005645_abnormal_hypothalamus_physiol0.72486371
135MP0000358_abnormal_cell_content/0.72251633
136MP0004381_abnormal_hair_follicle0.71760135
137MP0004808_abnormal_hematopoietic_stem0.70883285
138MP0003186_abnormal_redox_activity0.70609540
139MP0008875_abnormal_xenobiotic_pharmacok0.70157703
140MP0008057_abnormal_DNA_replication0.68350768
141MP0003937_abnormal_limbs/digits/tail_de0.66357644
142MP0005464_abnormal_platelet_physiology0.65250182
143MP0006035_abnormal_mitochondrial_morpho0.64164336
144MP0002877_abnormal_melanocyte_morpholog0.63153573
145MP0000477_abnormal_intestine_morphology0.63007418

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.19004282
2Abnormality of alanine metabolism (HP:0010916)4.14540487
3Hyperalaninemia (HP:0003348)4.14540487
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.14540487
5Abnormality of cochlea (HP:0000375)4.03956868
6Breast hypoplasia (HP:0003187)3.80983378
7Increased serum pyruvate (HP:0003542)3.74621242
8Abnormality of glycolysis (HP:0004366)3.74621242
9Reticulocytopenia (HP:0001896)3.54786804
10Microvesicular hepatic steatosis (HP:0001414)3.47524310
11Colon cancer (HP:0003003)3.46295192
12Abnormality of cells of the erythroid lineage (HP:0012130)3.41070937
13Abnormality of the labia minora (HP:0012880)3.19631802
14Morphological abnormality of the inner ear (HP:0011390)3.10107587
153-Methylglutaconic aciduria (HP:0003535)3.08572459
16Meckel diverticulum (HP:0002245)3.07748498
17Rough bone trabeculation (HP:0100670)3.01206122
18Ependymoma (HP:0002888)2.98563741
19Cerebral hypomyelination (HP:0006808)2.98120415
20Hypoglycemic coma (HP:0001325)2.97270839
21Macrocytic anemia (HP:0001972)2.96787893
22Abnormality of the ileum (HP:0001549)2.96210497
23Medial flaring of the eyebrow (HP:0010747)2.94207813
24Carpal bone hypoplasia (HP:0001498)2.83217954
25Abnormality of chromosome stability (HP:0003220)2.80985345
26Selective tooth agenesis (HP:0001592)2.77516232
27Impulsivity (HP:0100710)2.76780983
28Medulloblastoma (HP:0002885)2.72835241
29Generalized aminoaciduria (HP:0002909)2.70959348
30Volvulus (HP:0002580)2.70916778
31Hypothermia (HP:0002045)2.68862449
32Patellar aplasia (HP:0006443)2.64023003
33Abnormal lung lobation (HP:0002101)2.61334814
34Tubulointerstitial nephritis (HP:0001970)2.61200177
35Congenital primary aphakia (HP:0007707)2.60873903
36Intestinal atresia (HP:0011100)2.59834680
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56129525
38Gonadotropin excess (HP:0000837)2.53207886
39Microretrognathia (HP:0000308)2.53123128
40Gait imbalance (HP:0002141)2.50729284
41Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.49245739
42Vertebral hypoplasia (HP:0008417)2.49245739
43Vaginal atresia (HP:0000148)2.47715534
44Abnormal number of erythroid precursors (HP:0012131)2.47345667
45Absent thumb (HP:0009777)2.47013734
46Stenosis of the external auditory canal (HP:0000402)2.45482617
47Multiple enchondromatosis (HP:0005701)2.44697886
48Absent radius (HP:0003974)2.44664178
49Genital tract atresia (HP:0001827)2.44239788
50Irregular epiphyses (HP:0010582)2.44147249
51Ectopic kidney (HP:0000086)2.43803809
52Aplastic anemia (HP:0001915)2.41382577
53Aplasia/Hypoplasia of the patella (HP:0006498)2.41277762
5411 pairs of ribs (HP:0000878)2.38682634
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.37527143
56Nephrogenic diabetes insipidus (HP:0009806)2.37143825
57Oral leukoplakia (HP:0002745)2.35620058
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35411537
59Trismus (HP:0000211)2.32439141
60Nephronophthisis (HP:0000090)2.31912597
61Hyperglycinuria (HP:0003108)2.30792647
62Pancreatic cysts (HP:0001737)2.30431440
63Abnormal trabecular bone morphology (HP:0100671)2.29733201
64Pancreatic islet-cell hyperplasia (HP:0004510)2.28129242
65Methylmalonic acidemia (HP:0002912)2.27455254
66Supernumerary spleens (HP:0009799)2.27427056
67Abnormality of the anterior horn cell (HP:0006802)2.26007998
68Degeneration of anterior horn cells (HP:0002398)2.26007998
69Abnormal number of incisors (HP:0011064)2.26004051
70Hypoglycemic seizures (HP:0002173)2.23673750
71Basal cell carcinoma (HP:0002671)2.23498920
72Broad alveolar ridges (HP:0000187)2.23242667
73Anophthalmia (HP:0000528)2.18775338
74Hepatic necrosis (HP:0002605)2.18765049
75Self-mutilation (HP:0000742)2.18738681
76Muscle fiber atrophy (HP:0100295)2.18735493
77Acute necrotizing encephalopathy (HP:0006965)2.17272795
78Aplasia involving forearm bones (HP:0009822)2.14855100
79Absent forearm bone (HP:0003953)2.14855100
80Pallor (HP:0000980)2.14658693
81True hermaphroditism (HP:0010459)2.14236112
82Hyperglycinemia (HP:0002154)2.13327849
83Biliary tract neoplasm (HP:0100574)2.13001989
84Hypoplasia of the radius (HP:0002984)2.12250655
85Abnormality of serine family amino acid metabolism (HP:0010894)2.12097833
86Abnormality of glycine metabolism (HP:0010895)2.12097833
87Rectovaginal fistula (HP:0000143)2.12054875
88Rectal fistula (HP:0100590)2.12054875
89Type I transferrin isoform profile (HP:0003642)2.11785112
90Small intestinal stenosis (HP:0012848)2.11069531
91Duodenal stenosis (HP:0100867)2.11069531
92Glycosuria (HP:0003076)2.10973672
93Abnormality of urine glucose concentration (HP:0011016)2.10973672
94Nephroblastoma (Wilms tumor) (HP:0002667)2.10550095
95Facial hemangioma (HP:0000329)2.10003021
96Chromsome breakage (HP:0040012)2.09235594
97Abnormality of the duodenum (HP:0002246)2.08835719
98Neoplasm of the rectum (HP:0100743)2.07841214
99Absent hand (HP:0004050)2.06564067
100Conjugated hyperbilirubinemia (HP:0002908)2.06336808
101Rhabdomyolysis (HP:0003201)2.05642773
102Neoplasm of the colon (HP:0100273)2.05364524
103Embryonal renal neoplasm (HP:0011794)2.05234132
104Hyperinsulinemic hypoglycemia (HP:0000825)2.04625325
105Missing ribs (HP:0000921)2.03396076
106Triphalangeal thumb (HP:0001199)2.01504184
107Ileus (HP:0002595)2.01371318
108Abnormal biliary tract morphology (HP:0012440)2.00296301
109Acute encephalopathy (HP:0006846)1.99939135
110Renal cortical cysts (HP:0000803)1.98773087
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96823768
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96823768
113Proximal tubulopathy (HP:0000114)1.96528655
114Progressive macrocephaly (HP:0004481)1.96403986
115Oligodactyly (hands) (HP:0001180)1.95842506
116Abnormality of the renal medulla (HP:0100957)1.94595336
117Agnosia (HP:0010524)1.93085285
118Hepatoblastoma (HP:0002884)1.91209670
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90249317
120Abnormal protein glycosylation (HP:0012346)1.90005013
121Abnormal glycosylation (HP:0012345)1.90005013
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90005013
123Abnormal protein N-linked glycosylation (HP:0012347)1.90005013
124Neoplasm of the small intestine (HP:0100833)1.89955221
125Seborrheic dermatitis (HP:0001051)1.89942714
126Deviation of the thumb (HP:0009603)1.89498564
127Abnormality of the renal cortex (HP:0011035)1.89049630
128Occipital encephalocele (HP:0002085)1.88679528
129Anterior segment dysgenesis (HP:0007700)1.88571253
130Abolished electroretinogram (ERG) (HP:0000550)1.87577715
131Neoplasm of the pancreas (HP:0002894)1.87417505
132Cerebral edema (HP:0002181)1.86879751
133Pancreatic fibrosis (HP:0100732)1.86454360
134Abnormality of the preputium (HP:0100587)1.86439551
135Gout (HP:0001997)1.83571232
136Rhabdomyosarcoma (HP:0002859)1.83026369
137Optic nerve coloboma (HP:0000588)1.82878731
138Abnormality of serum amino acid levels (HP:0003112)1.82697358
139Vaginal fistula (HP:0004320)1.82680650
140Abnormality of pyrimidine metabolism (HP:0004353)1.82324449
141Increased CSF lactate (HP:0002490)1.82293382
142Proximal placement of thumb (HP:0009623)1.81611394
143Abnormality of abdominal situs (HP:0011620)1.81575598
144Abdominal situs inversus (HP:0003363)1.81575598
145Septo-optic dysplasia (HP:0100842)1.81430423
146Hepatocellular necrosis (HP:0001404)1.80980859
147Tongue fasciculations (HP:0001308)1.80569487
148Sloping forehead (HP:0000340)1.80176925
149Premature graying of hair (HP:0002216)1.80001186
150Decreased testicular size (HP:0008734)1.79808750
151Renal hypoplasia (HP:0000089)1.79449619
152Spondylolisthesis (HP:0003302)1.79200498
153Poor coordination (HP:0002370)1.79200492
154Increased serum lactate (HP:0002151)1.78220140
155Postaxial hand polydactyly (HP:0001162)1.76971535
156Abnormality of midbrain morphology (HP:0002418)1.76833304
157Molar tooth sign on MRI (HP:0002419)1.76833304
158Anal stenosis (HP:0002025)1.76723541
159Bifid tongue (HP:0010297)1.75790607
160Broad foot (HP:0001769)1.75534292
161Median cleft lip (HP:0000161)1.75450041
162Mitochondrial inheritance (HP:0001427)1.75100367
163Methylmalonic aciduria (HP:0012120)1.74452658
164Neoplasm of the oral cavity (HP:0100649)1.74079573
165IgM deficiency (HP:0002850)1.73842662
166Aplasia/hypoplasia of the humerus (HP:0006507)1.70409100
167Palpitations (HP:0001962)1.66884907
168Short thumb (HP:0009778)1.65986561
169Ovarian neoplasm (HP:0100615)1.65874203
170Stomach cancer (HP:0012126)1.64536622
171Cellular immunodeficiency (HP:0005374)1.63250570
172Horseshoe kidney (HP:0000085)1.62058217
173Persistence of primary teeth (HP:0006335)1.61351523
174Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60500326
175Short 1st metacarpal (HP:0010034)1.60500326
176Bone marrow hypocellularity (HP:0005528)1.59981037
177Hypobetalipoproteinemia (HP:0003563)1.59439541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.79205913
2MST43.02828958
3CDC72.98027454
4RPS6KB22.83994958
5WEE12.79401396
6PIK3CG2.79195485
7SRPK12.59937883
8MAP3K102.56574074
9TTK2.55667880
10MKNK22.51459144
11EIF2AK12.37400364
12VRK12.33489941
13TSSK62.30738383
14ACVR1B2.29651026
15STK162.28338534
16BUB12.23191525
17BCR2.18411060
18TRIM282.17610777
19LIMK12.12869379
20STK392.10961180
21TNIK2.10500070
22BRSK22.05985270
23FRK2.05106670
24TIE11.96457450
25PRPF4B1.93153480
26ZAK1.92860756
27PBK1.91561113
28STK241.85369530
29WNK41.75963409
30NME21.75660140
31TESK11.73895479
32TESK21.69964778
33PLK11.69640198
34PIK3CA1.64727232
35VRK21.63474543
36MAP3K41.62732479
37PLK31.57524868
38MAPKAPK31.57055734
39CASK1.54811320
40FLT31.53848063
41PLK41.52967306
42AURKB1.47704358
43FGFR21.46692611
44ILK1.42748278
45LMTK21.42446143
46PINK11.39895161
47BMPR1B1.34882565
48MELK1.32033157
49PASK1.30735838
50CDK121.30130441
51EEF2K1.28019606
52EIF2AK31.27914595
53OXSR11.27780827
54MAP3K81.20946840
55BRSK11.17393946
56PAK41.16878938
57CDK71.09739505
58STK41.09386088
59STK31.04627996
60TGFBR11.03938562
61EPHA21.02243120
62DYRK31.00185597
63MAP2K70.98989850
64CSNK1G30.94567537
65MYLK0.93472844
66OBSCN0.93065239
67STK100.92722689
68CHEK10.92158688
69TLK10.92010948
70DYRK20.91262084
71ATR0.90901416
72NME10.89831611
73MINK10.89305417
74CSNK1G10.89214228
75PLK20.88610545
76MATK0.86964340
77CHEK20.86899390
78MKNK10.86489124
79FGFR10.86108522
80GRK10.85587579
81CSNK1G20.85092417
82RPS6KA40.84455610
83BCKDK0.83249335
84AURKA0.82455505
85MAP3K90.81851474
86CSNK1A1L0.81246081
87TEC0.81229759
88NEK20.81213325
89STK38L0.78899262
90ATM0.78150933
91WNK30.77932100
92MAPK130.76815638
93BRD40.76795300
94LRRK20.76030585
95TAF10.75738979
96CCNB10.75531619
97RPS6KA50.74468565
98PAK10.73234363
99SCYL20.72814872
100CSNK2A20.71590781
101EPHB20.70034193
102IRAK20.68841065
103ERBB30.66311943
104CDK60.64883127
105UHMK10.64734810
106ALK0.64380049
107YES10.63154845
108CDK20.63075726
109AKT30.62913413
110AKT20.62714791
111MAP3K120.62052676
112PRKCI0.61395995
113INSRR0.61369587
114CSNK2A10.60458032
115LATS10.59179053
116CDK80.57253624
117PRKG20.56978411
118MARK30.54846724
119MAP3K30.53264821
120CDK30.52412853
121TYRO30.51525558
122MTOR0.49920008
123PNCK0.48056294
124ADRBK20.43646538
125PAK30.42083005
126CDK10.39735147
127PRKCE0.39556595
128ITK0.38768409
129CSNK1E0.36566978
130NUAK10.36415574
131LCK0.35637712
132CLK10.34882362
133PRKDC0.34217556
134TAOK20.34057547
135RPS6KB10.33921750
136EPHA40.33215267
137PDK20.33030684
138KIT0.32830441
139PRKCG0.32789180
140NEK10.32404407
141CSNK1A10.30727916
142MAP2K30.30419025
143NLK0.30380967
144PRKG10.29537941
145MET0.28968423
146MAP2K40.28339513
147EGFR0.27593200
148MAP3K50.26551737
149IRAK10.25444953
150EIF2AK20.24197331

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.76221654
2RNA polymerase_Homo sapiens_hsa030203.86683725
3DNA replication_Homo sapiens_hsa030303.76973796
4Mismatch repair_Homo sapiens_hsa034303.60438132
5Proteasome_Homo sapiens_hsa030503.37211048
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37042283
7Propanoate metabolism_Homo sapiens_hsa006403.23980621
8Spliceosome_Homo sapiens_hsa030402.99667095
9RNA transport_Homo sapiens_hsa030132.80656450
10Homologous recombination_Homo sapiens_hsa034402.67176636
11Base excision repair_Homo sapiens_hsa034102.49463794
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33934176
13Pyrimidine metabolism_Homo sapiens_hsa002402.27245628
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26441640
15Basal transcription factors_Homo sapiens_hsa030222.25820300
16One carbon pool by folate_Homo sapiens_hsa006702.23720503
17Nucleotide excision repair_Homo sapiens_hsa034202.15456735
18Cell cycle_Homo sapiens_hsa041102.07608397
19Non-homologous end-joining_Homo sapiens_hsa034502.00974748
20RNA degradation_Homo sapiens_hsa030181.89845697
21Butanoate metabolism_Homo sapiens_hsa006501.64704135
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63717812
23mRNA surveillance pathway_Homo sapiens_hsa030151.58321250
24Fatty acid degradation_Homo sapiens_hsa000711.55840213
25Fatty acid metabolism_Homo sapiens_hsa012121.49948730
26Folate biosynthesis_Homo sapiens_hsa007901.45137957
27Peroxisome_Homo sapiens_hsa041461.41801764
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35352097
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31929248
30Purine metabolism_Homo sapiens_hsa002301.26980057
31Fanconi anemia pathway_Homo sapiens_hsa034601.21428319
32Biosynthesis of amino acids_Homo sapiens_hsa012301.19599894
33Tryptophan metabolism_Homo sapiens_hsa003801.17739127
34Epstein-Barr virus infection_Homo sapiens_hsa051691.17538607
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.13920309
36Parkinsons disease_Homo sapiens_hsa050121.12293537
37beta-Alanine metabolism_Homo sapiens_hsa004101.10170315
38Sulfur relay system_Homo sapiens_hsa041221.08363729
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07761676
40Systemic lupus erythematosus_Homo sapiens_hsa053221.07402079
41Steroid biosynthesis_Homo sapiens_hsa001001.00542017
42Phototransduction_Homo sapiens_hsa047440.99055029
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.98068831
44Vitamin digestion and absorption_Homo sapiens_hsa049770.97659229
45Pentose phosphate pathway_Homo sapiens_hsa000300.96450207
46Fatty acid biosynthesis_Homo sapiens_hsa000610.96163255
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92744794
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92143825
49p53 signaling pathway_Homo sapiens_hsa041150.89717455
50Oxidative phosphorylation_Homo sapiens_hsa001900.88581140
51Protein export_Homo sapiens_hsa030600.88145979
52Glutathione metabolism_Homo sapiens_hsa004800.86482589
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86264046
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85312962
55Huntingtons disease_Homo sapiens_hsa050160.81570213
56Histidine metabolism_Homo sapiens_hsa003400.81492467
57Viral carcinogenesis_Homo sapiens_hsa052030.81341688
58Nitrogen metabolism_Homo sapiens_hsa009100.80824480
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79734204
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78009461
61Retinol metabolism_Homo sapiens_hsa008300.75895062
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73968401
63Fructose and mannose metabolism_Homo sapiens_hsa000510.73726941
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71573859
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69654358
66Carbon metabolism_Homo sapiens_hsa012000.68174234
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66064734
68Arginine and proline metabolism_Homo sapiens_hsa003300.65085677
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64222450
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.62101368
71Primary immunodeficiency_Homo sapiens_hsa053400.61400644
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.60025836
73Selenocompound metabolism_Homo sapiens_hsa004500.59335408
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57884808
75Antigen processing and presentation_Homo sapiens_hsa046120.56346402
76Galactose metabolism_Homo sapiens_hsa000520.56206870
77Hedgehog signaling pathway_Homo sapiens_hsa043400.55931528
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55609591
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55208356
80TGF-beta signaling pathway_Homo sapiens_hsa043500.54154851
81Chemical carcinogenesis_Homo sapiens_hsa052040.53676861
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.52988641
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.51621148
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50630745
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49722267
86Alcoholism_Homo sapiens_hsa050340.49614486
87Arachidonic acid metabolism_Homo sapiens_hsa005900.49046633
88Wnt signaling pathway_Homo sapiens_hsa043100.48361535
89Metabolic pathways_Homo sapiens_hsa011000.48059056
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48053298
91Acute myeloid leukemia_Homo sapiens_hsa052210.47914024
92Arginine biosynthesis_Homo sapiens_hsa002200.47815259
93Thyroid cancer_Homo sapiens_hsa052160.46350087
94Notch signaling pathway_Homo sapiens_hsa043300.45844039
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45312837
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44914812
97Fatty acid elongation_Homo sapiens_hsa000620.44587038
98Endometrial cancer_Homo sapiens_hsa052130.44481370
99Complement and coagulation cascades_Homo sapiens_hsa046100.44456258
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43761761
101mTOR signaling pathway_Homo sapiens_hsa041500.42523526
102Asthma_Homo sapiens_hsa053100.42452269
103Lysine degradation_Homo sapiens_hsa003100.42350110
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42129103
105Glycerolipid metabolism_Homo sapiens_hsa005610.42087515
106Colorectal cancer_Homo sapiens_hsa052100.41453308
107Tight junction_Homo sapiens_hsa045300.41240242
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41193929
109N-Glycan biosynthesis_Homo sapiens_hsa005100.40876537
110Pyruvate metabolism_Homo sapiens_hsa006200.40779676
111Phenylalanine metabolism_Homo sapiens_hsa003600.40050486
112Starch and sucrose metabolism_Homo sapiens_hsa005000.39041620
113Oocyte meiosis_Homo sapiens_hsa041140.35793882
114Renin-angiotensin system_Homo sapiens_hsa046140.35484241
115Tyrosine metabolism_Homo sapiens_hsa003500.34953092
116Apoptosis_Homo sapiens_hsa042100.34683320
117Herpes simplex infection_Homo sapiens_hsa051680.34000188
118HTLV-I infection_Homo sapiens_hsa051660.33311733
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31560302
120Alzheimers disease_Homo sapiens_hsa050100.31393453
121Hippo signaling pathway_Homo sapiens_hsa043900.31121393
122Linoleic acid metabolism_Homo sapiens_hsa005910.30984720
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30084342
124Sulfur metabolism_Homo sapiens_hsa009200.29787082
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29283663
126HIF-1 signaling pathway_Homo sapiens_hsa040660.28905471
127Regulation of autophagy_Homo sapiens_hsa041400.27167914
128Caffeine metabolism_Homo sapiens_hsa002320.25638330
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.25164488
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25077928
131Vitamin B6 metabolism_Homo sapiens_hsa007500.23457914
132Prostate cancer_Homo sapiens_hsa052150.21338548
133Fat digestion and absorption_Homo sapiens_hsa049750.19327705
134Basal cell carcinoma_Homo sapiens_hsa052170.16393112
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15343741

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