NECAB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.96919049
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87516170
3synaptic vesicle exocytosis (GO:0016079)5.48701565
4glutamate secretion (GO:0014047)5.47174360
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.44803770
6neuron cell-cell adhesion (GO:0007158)5.19732935
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18036735
8synaptic vesicle maturation (GO:0016188)5.14948610
9protein localization to synapse (GO:0035418)5.07791108
10locomotory exploration behavior (GO:0035641)5.02845896
11sodium ion export (GO:0071436)4.90663720
12neurotransmitter-gated ion channel clustering (GO:0072578)4.89969413
13regulation of glutamate receptor signaling pathway (GO:1900449)4.86865005
14regulation of synaptic vesicle exocytosis (GO:2000300)4.85305895
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.82953555
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.72199250
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.72194176
18neurotransmitter secretion (GO:0007269)4.69364452
19gamma-aminobutyric acid transport (GO:0015812)4.68963373
20L-amino acid import (GO:0043092)4.52925738
21central nervous system myelination (GO:0022010)4.32723636
22axon ensheathment in central nervous system (GO:0032291)4.32723636
23regulation of synaptic vesicle transport (GO:1902803)4.29909698
24exploration behavior (GO:0035640)4.24890249
25positive regulation of synapse maturation (GO:0090129)4.16948264
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.16897841
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12683841
28layer formation in cerebral cortex (GO:0021819)4.06515171
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05726751
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.00278805
31regulation of neuronal synaptic plasticity (GO:0048168)3.97796828
32neuronal action potential propagation (GO:0019227)3.97401894
33neurotransmitter uptake (GO:0001504)3.96999832
34potassium ion homeostasis (GO:0055075)3.93604693
35potassium ion import (GO:0010107)3.91787305
36neuronal ion channel clustering (GO:0045161)3.81140778
37regulation of voltage-gated calcium channel activity (GO:1901385)3.80925224
38amino acid import (GO:0043090)3.80685955
39proline transport (GO:0015824)3.80202297
40pyrimidine nucleobase catabolic process (GO:0006208)3.74257072
41neuron-neuron synaptic transmission (GO:0007270)3.73856757
42synaptic transmission, glutamatergic (GO:0035249)3.72274560
43regulation of synapse structural plasticity (GO:0051823)3.71260461
44presynaptic membrane assembly (GO:0097105)3.69086284
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68570457
46neurotransmitter transport (GO:0006836)3.67033033
47glutamate receptor signaling pathway (GO:0007215)3.65339942
48postsynaptic membrane organization (GO:0001941)3.64110763
49positive regulation of membrane potential (GO:0045838)3.62936715
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59029438
51regulation of neurotransmitter levels (GO:0001505)3.47938176
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.46881784
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46465312
54cell communication by electrical coupling (GO:0010644)3.44318883
55positive regulation of dendritic spine development (GO:0060999)3.42332730
56regulation of postsynaptic membrane potential (GO:0060078)3.40368316
57neuron recognition (GO:0008038)3.37136419
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35025193
59presynaptic membrane organization (GO:0097090)3.32975921
60cellular sodium ion homeostasis (GO:0006883)3.32609713
61nucleobase catabolic process (GO:0046113)3.32443078
62response to histamine (GO:0034776)3.32421176
63long-term memory (GO:0007616)3.32012618
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.31400963
65activation of protein kinase A activity (GO:0034199)3.31294623
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.30816649
67negative regulation of dendrite morphogenesis (GO:0050774)3.26591402
68dendritic spine morphogenesis (GO:0060997)3.26220751
69regulation of synaptic plasticity (GO:0048167)3.25802359
70regulation of synapse maturation (GO:0090128)3.24258105
71behavioral response to cocaine (GO:0048148)3.21307058
72regulation of cell communication by electrical coupling (GO:0010649)3.20706782
73regulation of neurotransmitter secretion (GO:0046928)3.19976132
74long-term synaptic potentiation (GO:0060291)3.18356692
75regulation of female receptivity (GO:0045924)3.16580799
76neuromuscular process controlling posture (GO:0050884)3.16197957
77synapse assembly (GO:0007416)3.14766171
78cerebellar granule cell differentiation (GO:0021707)3.14304690
79C4-dicarboxylate transport (GO:0015740)3.14267745
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13849542
81synaptic vesicle transport (GO:0048489)3.11469776
82establishment of synaptic vesicle localization (GO:0097480)3.11469776
83regulation of dendritic spine morphogenesis (GO:0061001)3.11023406
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10691269
85negative regulation of dendrite development (GO:2000171)3.10451945
86acidic amino acid transport (GO:0015800)3.09954820
87positive regulation of neurotransmitter secretion (GO:0001956)3.07203269
88intraspecies interaction between organisms (GO:0051703)3.06965601
89social behavior (GO:0035176)3.06965601
90transmission of nerve impulse (GO:0019226)3.06266131
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05583577
92synaptic vesicle endocytosis (GO:0048488)3.03972526
93auditory behavior (GO:0031223)3.02094006
94serotonin metabolic process (GO:0042428)3.01338198
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00149168
96calcium ion-dependent exocytosis (GO:0017156)2.99903254
97cell communication involved in cardiac conduction (GO:0086065)2.98556843
98neuromuscular synaptic transmission (GO:0007274)2.96096994
99response to auditory stimulus (GO:0010996)2.95757748
100regulation of glutamate secretion (GO:0014048)2.94557652
101learning (GO:0007612)2.92138070
102female mating behavior (GO:0060180)2.91810635
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91721349
104startle response (GO:0001964)2.90812208
105axonal fasciculation (GO:0007413)2.89619318
106dendrite morphogenesis (GO:0048813)2.88295826
107membrane depolarization (GO:0051899)2.88139112
108signal release (GO:0023061)2.88121187
109cerebellar Purkinje cell differentiation (GO:0021702)2.85853853
110regulation of neurotransmitter transport (GO:0051588)2.85612430
111positive regulation of synaptic transmission (GO:0050806)2.84708447
112positive regulation of neurotransmitter transport (GO:0051590)2.81764932
113regulation of vesicle fusion (GO:0031338)2.81402843
114neuromuscular process controlling balance (GO:0050885)2.80752947
115regulation of synaptic transmission, GABAergic (GO:0032228)2.80112006
116regulation of dendritic spine development (GO:0060998)2.79803883
117detection of calcium ion (GO:0005513)2.78281154
118cellular potassium ion homeostasis (GO:0030007)2.78176982
119synaptic transmission (GO:0007268)2.78042232
120regulation of synaptic transmission (GO:0050804)2.77092499
121membrane depolarization during action potential (GO:0086010)2.74402155
122vesicle transport along microtubule (GO:0047496)2.74029502
123behavioral fear response (GO:0001662)2.73929981
124behavioral defense response (GO:0002209)2.73929981
125mating behavior (GO:0007617)2.73054868
126synapse organization (GO:0050808)2.71793833
127membrane hyperpolarization (GO:0060081)2.69647063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75822299
2GBX2_23144817_ChIP-Seq_PC3_Human3.89713935
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87916221
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77618169
5REST_21632747_ChIP-Seq_MESCs_Mouse2.65714253
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64808995
7TAF15_26573619_Chip-Seq_HEK293_Human2.50284458
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34668365
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33691271
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33047831
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30683731
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30587439
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25604951
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25604951
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23436081
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22537962
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21920016
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17928854
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.16764742
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.14290445
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.12350354
22DROSHA_22980978_ChIP-Seq_HELA_Human2.11144268
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08070947
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.95421986
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95155010
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95029592
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93160861
28AR_21572438_ChIP-Seq_LNCaP_Human1.88825742
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84646879
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.81975511
31SMAD4_21799915_ChIP-Seq_A2780_Human1.80028824
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73217316
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72114873
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70130387
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66271023
36P300_19829295_ChIP-Seq_ESCs_Human1.62623771
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62548867
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50901840
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48715062
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47840473
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.43110190
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.41620571
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40235103
44AR_25329375_ChIP-Seq_VCAP_Human1.39136103
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.38037978
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37255403
47ZNF274_21170338_ChIP-Seq_K562_Hela1.36643157
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34309067
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33042074
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.32722447
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32574677
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.31641743
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31246901
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.30859369
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30840618
56STAT3_23295773_ChIP-Seq_U87_Human1.29199463
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27847838
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.27745695
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26021037
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23609526
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23393603
62SOX9_26525672_Chip-Seq_HEART_Mouse1.19753270
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19055566
64IGF1R_20145208_ChIP-Seq_DFB_Human1.18756744
65TCF4_23295773_ChIP-Seq_U87_Human1.16868361
66FUS_26573619_Chip-Seq_HEK293_Human1.15394329
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14808294
68AR_19668381_ChIP-Seq_PC3_Human1.14272077
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13897859
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13422148
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12687042
72RNF2_27304074_Chip-Seq_NSC_Mouse1.12020282
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11972186
74P53_22387025_ChIP-Seq_ESCs_Mouse1.11146002
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10488001
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09182418
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.08954375
78ER_23166858_ChIP-Seq_MCF-7_Human1.08343828
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07737904
80* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07677478
81BCAT_22108803_ChIP-Seq_LS180_Human1.07407393
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06931040
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.06701109
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06517487
85HTT_18923047_ChIP-ChIP_STHdh_Human1.05975488
86EWS_26573619_Chip-Seq_HEK293_Human1.05184999
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05139796
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.04911212
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.04520664
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04211207
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03646806
92JUN_21703547_ChIP-Seq_K562_Human1.03633455
93RUNX2_22187159_ChIP-Seq_PCA_Human1.03243303
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02114167
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02085710
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01423299
97* AHR_22903824_ChIP-Seq_MCF-7_Human1.01201946
98* KDM2B_26808549_Chip-Seq_REH_Human1.00880814
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00794254
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99771196
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99715233
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99262148
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.98772860
104VDR_22108803_ChIP-Seq_LS180_Human0.98363290
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97855731
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97003276
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95243179
108* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94430555
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94393814
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94393814
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.94199268
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93731364
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92540053
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91253421
115CBP_20019798_ChIP-Seq_JUKART_Human0.91253421
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.90561720
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90002389
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89874090
119TP53_18474530_ChIP-ChIP_U2OS_Human0.89817146
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88791023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.73949213
2MP0003880_abnormal_central_pattern4.30668393
3MP0003635_abnormal_synaptic_transmissio4.00706939
4MP0004270_analgesia3.63659311
5MP0002822_catalepsy3.56672131
6MP0009745_abnormal_behavioral_response3.42300545
7MP0001968_abnormal_touch/_nociception3.28423251
8MP0002063_abnormal_learning/memory/cond3.27627291
9MP0009046_muscle_twitch3.19720964
10MP0002064_seizures3.13046468
11MP0002572_abnormal_emotion/affect_behav2.78376907
12MP0002735_abnormal_chemical_nociception2.76779263
13MP0002734_abnormal_mechanical_nocicepti2.71537455
14MP0002736_abnormal_nociception_after2.57802387
15MP0005423_abnormal_somatic_nervous2.39767077
16MP0002272_abnormal_nervous_system2.34933276
17MP0001486_abnormal_startle_reflex2.34660648
18MP0009780_abnormal_chondrocyte_physiolo2.22950177
19MP0002733_abnormal_thermal_nociception2.20809889
20MP0003329_amyloid_beta_deposits2.18577307
21MP0001501_abnormal_sleep_pattern2.14985093
22MP0001440_abnormal_grooming_behavior2.08805490
23MP0002067_abnormal_sensory_capabilities1.96387245
24MP0006276_abnormal_autonomic_nervous1.95056191
25MP0001970_abnormal_pain_threshold1.94669233
26MP0001984_abnormal_olfaction1.92108041
27MP0004924_abnormal_behavior1.82418797
28MP0005386_behavior/neurological_phenoty1.82418797
29MP0008877_abnormal_DNA_methylation1.76402672
30MP0002557_abnormal_social/conspecific_i1.72331586
31MP0002184_abnormal_innervation1.72022490
32MP0003879_abnormal_hair_cell1.69980915
33MP0004811_abnormal_neuron_physiology1.68282823
34MP0002139_abnormal_hepatobiliary_system1.65871412
35MP0000778_abnormal_nervous_system1.63664825
36MP0005646_abnormal_pituitary_gland1.62834114
37MP0002909_abnormal_adrenal_gland1.58047115
38MP0005085_abnormal_gallbladder_physiolo1.57707295
39MP0005360_urolithiasis1.57459315
40MP0008569_lethality_at_weaning1.54505353
41MP0004147_increased_porphyrin_level1.52204253
42MP0004858_abnormal_nervous_system1.43105166
43MP0000920_abnormal_myelination1.41683450
44MP0002837_dystrophic_cardiac_calcinosis1.40333510
45MP0000955_abnormal_spinal_cord1.37630872
46MP0002066_abnormal_motor_capabilities/c1.34470914
47MP0003633_abnormal_nervous_system1.33710982
48MP0008875_abnormal_xenobiotic_pharmacok1.33272685
49MP0003123_paternal_imprinting1.31108508
50MP0002876_abnormal_thyroid_physiology1.27270571
51MP0001529_abnormal_vocalization1.26726461
52MP0001485_abnormal_pinna_reflex1.26046801
53MP0005365_abnormal_bile_salt1.25919342
54MP0001502_abnormal_circadian_rhythm1.25106816
55MP0000604_amyloidosis1.24913809
56MP0002882_abnormal_neuron_morphology1.23679407
57MP0008872_abnormal_physiological_respon1.16916827
58MP0003631_nervous_system_phenotype1.14985336
59MP0004142_abnormal_muscle_tone1.13476157
60MP0001188_hyperpigmentation1.12776350
61MP0001905_abnormal_dopamine_level1.12705123
62MP0004885_abnormal_endolymph1.07992550
63MP0008874_decreased_physiological_sensi1.06752935
64MP0000569_abnormal_digit_pigmentation1.06731029
65MP0005535_abnormal_body_temperature1.02165189
66MP0005645_abnormal_hypothalamus_physiol1.00184729
67MP0010329_abnormal_lipoprotein_level0.99353679
68MP0003787_abnormal_imprinting0.97372087
69MP0005410_abnormal_fertilization0.96744766
70MP0003121_genomic_imprinting0.96490252
71MP0002069_abnormal_eating/drinking_beha0.94857563
72MP0002152_abnormal_brain_morphology0.93975293
73MP0002229_neurodegeneration0.93727278
74MP0005551_abnormal_eye_electrophysiolog0.91777349
75MP0002638_abnormal_pupillary_reflex0.89513624
76MP0003283_abnormal_digestive_organ0.89316902
77MP0001177_atelectasis0.82569755
78MP0003137_abnormal_impulse_conducting0.80915835
79MP0003632_abnormal_nervous_system0.80227173
80MP0004085_abnormal_heartbeat0.79645005
81MP0004130_abnormal_muscle_cell0.77804210
82MP0003690_abnormal_glial_cell0.76004099
83MP0003122_maternal_imprinting0.75191573
84MP0002102_abnormal_ear_morphology0.74931981
85MP0001986_abnormal_taste_sensitivity0.74737808
86MP0002090_abnormal_vision0.73363453
87MP0005253_abnormal_eye_physiology0.72060690
88MP0001963_abnormal_hearing_physiology0.70993859
89MP0004742_abnormal_vestibular_system0.67744390
90MP0003868_abnormal_feces_composition0.66060045
91MP0004043_abnormal_pH_regulation0.65900843
92MP0000013_abnormal_adipose_tissue0.63132281
93MP0010386_abnormal_urinary_bladder0.62518183
94MP0005187_abnormal_penis_morphology0.62382076
95MP0001299_abnormal_eye_distance/0.61847936
96MP0002752_abnormal_somatic_nervous0.61319331
97MP0003195_calcinosis0.60439143
98MP0003634_abnormal_glial_cell0.60397393
99MP0000751_myopathy0.59176019
100MP0005499_abnormal_olfactory_system0.58504133
101MP0005394_taste/olfaction_phenotype0.58504133
102MP0005448_abnormal_energy_balance0.58397664
103MP0004484_altered_response_of0.57898089
104MP0001346_abnormal_lacrimal_gland0.56728280
105MP0003075_altered_response_to0.56604095
106MP0005584_abnormal_enzyme/coenzyme_acti0.56442622
107MP0010769_abnormal_survival0.56146193
108MP0000639_abnormal_adrenal_gland0.55879745
109MP0004215_abnormal_myocardial_fiber0.55708894
110MP0002118_abnormal_lipid_homeostasis0.55417870
111MP0003119_abnormal_digestive_system0.55212825
112MP0003890_abnormal_embryonic-extraembry0.55184516
113MP0006292_abnormal_olfactory_placode0.54267029
114MP0010768_mortality/aging0.54104663
115MP0002082_postnatal_lethality0.53968975
116MP0010770_preweaning_lethality0.53968975
117MP0001664_abnormal_digestion0.53852261
118MP0006072_abnormal_retinal_apoptosis0.52954568
119MP0003698_abnormal_male_reproductive0.52396017
120MP0003861_abnormal_nervous_system0.50400709
121MP0005167_abnormal_blood-brain_barrier0.50058653
122MP0003956_abnormal_body_size0.50039194
123MP0008961_abnormal_basal_metabolism0.49834109
124MP0003252_abnormal_bile_duct0.49578013
125MP0000631_abnormal_neuroendocrine_gland0.49536226
126MP0005332_abnormal_amino_acid0.48866315
127MP0000579_abnormal_nail_morphology0.48847652
128MP0000026_abnormal_inner_ear0.45126521

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.86077768
2Myokymia (HP:0002411)5.69976998
3Focal seizures (HP:0007359)5.54408319
4Hyperventilation (HP:0002883)5.30205333
5Epileptic encephalopathy (HP:0200134)5.19976445
6Visual hallucinations (HP:0002367)4.91809173
7Atonic seizures (HP:0010819)4.57596642
8Febrile seizures (HP:0002373)4.33826610
9Absence seizures (HP:0002121)4.20631996
10Dialeptic seizures (HP:0011146)3.95648154
11Generalized tonic-clonic seizures (HP:0002069)3.82588314
12Progressive cerebellar ataxia (HP:0002073)3.71958026
13Poor eye contact (HP:0000817)3.62668403
14Broad-based gait (HP:0002136)3.56060568
15Cerebral hypomyelination (HP:0006808)3.53262405
16Abnormal social behavior (HP:0012433)3.48722123
17Impaired social interactions (HP:0000735)3.48722123
18Progressive inability to walk (HP:0002505)3.19792800
19Supranuclear gaze palsy (HP:0000605)3.14748449
20Mutism (HP:0002300)3.11403122
21Excessive salivation (HP:0003781)3.05963204
22Drooling (HP:0002307)3.05963204
23Impaired vibration sensation in the lower limbs (HP:0002166)3.02711505
24Gaze-evoked nystagmus (HP:0000640)3.01637916
25Cerebral inclusion bodies (HP:0100314)3.01073381
26Abnormality of the lower motor neuron (HP:0002366)2.95558544
27Inability to walk (HP:0002540)2.95444642
28Neurofibrillary tangles (HP:0002185)2.92301475
29Papilledema (HP:0001085)2.91630769
30Status epilepticus (HP:0002133)2.90330892
31Action tremor (HP:0002345)2.89815576
32Epileptiform EEG discharges (HP:0011182)2.87849772
33Ankle clonus (HP:0011448)2.85844627
34Urinary bladder sphincter dysfunction (HP:0002839)2.83237912
35Dysdiadochokinesis (HP:0002075)2.82308371
36Abnormal eating behavior (HP:0100738)2.79283250
37EEG with generalized epileptiform discharges (HP:0011198)2.79139797
38Torticollis (HP:0000473)2.76954020
39Depression (HP:0000716)2.72288605
40Amyotrophic lateral sclerosis (HP:0007354)2.70274873
41Hypsarrhythmia (HP:0002521)2.69705435
42Postural instability (HP:0002172)2.69528793
43Anxiety (HP:0000739)2.69515271
44Limb dystonia (HP:0002451)2.66034995
45Truncal ataxia (HP:0002078)2.65821394
46Polyphagia (HP:0002591)2.63567162
47CNS hypomyelination (HP:0003429)2.60292600
48Focal dystonia (HP:0004373)2.60064578
49Abnormality of the corticospinal tract (HP:0002492)2.59159259
50Amblyopia (HP:0000646)2.59101470
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59068566
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.59068566
53Insidious onset (HP:0003587)2.58486487
54Termporal pattern (HP:0011008)2.58486487
55Pheochromocytoma (HP:0002666)2.56739175
56Tetraplegia (HP:0002445)2.52523135
57Absent speech (HP:0001344)2.51274288
58Generalized myoclonic seizures (HP:0002123)2.51073423
59Blue irides (HP:0000635)2.50571909
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.44121618
61Absent/shortened dynein arms (HP:0200106)2.44121618
62Craniofacial dystonia (HP:0012179)2.43678260
63Dysmetria (HP:0001310)2.42111464
64Bradykinesia (HP:0002067)2.38784162
65Urinary urgency (HP:0000012)2.37021693
66Spastic gait (HP:0002064)2.35935756
67Impaired vibratory sensation (HP:0002495)2.34481615
68Abnormality of binocular vision (HP:0011514)2.34414025
69Diplopia (HP:0000651)2.34414025
70Increased circulating renin level (HP:0000848)2.32757300
71Scanning speech (HP:0002168)2.30919258
72Bundle branch block (HP:0011710)2.28113715
73Fair hair (HP:0002286)2.27936980
74Neuroendocrine neoplasm (HP:0100634)2.27245545
75Generalized hypopigmentation of hair (HP:0011358)2.25585642
76Protruding tongue (HP:0010808)2.23728279
77Genetic anticipation (HP:0003743)2.22418434
78Spastic tetraparesis (HP:0001285)2.20442834
79Stereotypic behavior (HP:0000733)2.20171520
80Choreoathetosis (HP:0001266)2.19682812
81Impaired smooth pursuit (HP:0007772)2.18489463
82Akinesia (HP:0002304)2.15931011
83Fetal akinesia sequence (HP:0001989)2.15322517
84Abnormality of the labia minora (HP:0012880)2.14937200
85Gait imbalance (HP:0002141)2.14889110
86Dysmetric saccades (HP:0000641)2.11974946
87Hemiparesis (HP:0001269)2.09949931
88Sleep apnea (HP:0010535)2.09168150
89Intention tremor (HP:0002080)2.08493682
90Agitation (HP:0000713)2.08421832
91Inappropriate behavior (HP:0000719)2.07527109
92Deep venous thrombosis (HP:0002625)2.04431412
93Morphological abnormality of the pyramidal tract (HP:0002062)2.04181727
94Abnormality of ocular smooth pursuit (HP:0000617)2.00666778
95Cholecystitis (HP:0001082)2.00309598
96Abnormal gallbladder physiology (HP:0012438)2.00309598
97Agnosia (HP:0010524)2.00025050
98Ventricular fibrillation (HP:0001663)1.98053458
99Lower limb muscle weakness (HP:0007340)1.96932339
100Annular pancreas (HP:0001734)1.94765363
101Abnormality of salivation (HP:0100755)1.94009584
102Spastic tetraplegia (HP:0002510)1.91852669
103Gait ataxia (HP:0002066)1.89930302
104Delusions (HP:0000746)1.89670335
105Syncope (HP:0001279)1.86807847
106Incomplete penetrance (HP:0003829)1.86553870
107Megalencephaly (HP:0001355)1.85341810
108Sensory axonal neuropathy (HP:0003390)1.85017599
109Peripheral hypomyelination (HP:0007182)1.82873962
110Poor suck (HP:0002033)1.81336836
111Clonus (HP:0002169)1.81265717
112Hyperthyroidism (HP:0000836)1.79701027
113Hemiplegia (HP:0002301)1.79038047
114Specific learning disability (HP:0001328)1.76947186
115Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76256308
116Neuronal loss in central nervous system (HP:0002529)1.75612387
117Prolonged partial thromboplastin time (HP:0003645)1.74110268
118Rigidity (HP:0002063)1.73826838
119Heterochromia iridis (HP:0001100)1.73446615
120Abnormal EKG (HP:0003115)1.73424309
121Resting tremor (HP:0002322)1.73023448
122Abnormality of saccadic eye movements (HP:0000570)1.66534302
123Hyperinsulinemic hypoglycemia (HP:0000825)1.64756248
124Aqueductal stenosis (HP:0002410)1.64541951
125Muscular hypotonia of the trunk (HP:0008936)1.64221431
126Apathy (HP:0000741)1.62128682
127Heart block (HP:0012722)1.61648063
128Hypoglycemic coma (HP:0001325)1.61207806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.17978504
2NTRK33.96935919
3MAP3K93.70610232
4CASK3.47142286
5MAP3K43.41653402
6EPHA43.41519826
7MAP2K73.19828382
8DAPK22.69404615
9MINK12.68830498
10MAP2K42.49359055
11MAP3K122.29075453
12NTRK21.98480816
13NTRK11.93484283
14BMPR1B1.84075245
15PAK61.80366462
16DAPK11.68124229
17KSR21.66591500
18PLK21.62420570
19CAMKK11.61691798
20PDK31.53199248
21PDK41.53199248
22GRK51.51334618
23LATS21.44405686
24PNCK1.41315937
25KSR11.40962477
26CDK51.39852777
27RIPK41.36988842
28MAPK131.36926307
29TNIK1.35960380
30CCNB11.31499448
31PRKCG1.24062092
32CDK191.22972170
33PHKG11.22545804
34PHKG21.22545804
35PRKD31.21050158
36CAMKK21.12138072
37SIK21.12033275
38PLK31.08130228
39ALK1.05591202
40MKNK21.05587046
41MAP3K21.02818668
42ARAF1.02210612
43TRIM280.98642614
44FES0.98049342
45CAMK2A0.97859174
46PRPF4B0.95399401
47STK380.92925092
48AKT30.92144933
49CSNK1G20.91754574
50RET0.91213013
51SGK20.86129721
52SGK4940.85392123
53SGK2230.85392123
54PDK20.85043649
55MAP3K60.79149851
56CDK180.79101783
57CDK140.77351235
58ERBB40.76794401
59CDK150.75414332
60PTK2B0.74358096
61BRSK10.74105633
62CAMK10.73313486
63NEK60.72359161
64LIMK10.72074776
65ACVR1B0.71923641
66STK390.71659490
67UHMK10.68876711
68STK110.68444992
69PRKCZ0.67647107
70MAP3K130.66299574
71TYRO30.66166096
72SGK30.65146209
73DYRK1A0.63047945
74CDK11A0.62864183
75PRKCE0.62663224
76TAOK10.62024171
77DMPK0.61920345
78MAPK120.61895157
79CAMK2B0.61770988
80BMPR20.61144487
81PDK10.60967941
82PAK30.60314431
83OXSR10.59866405
84SCYL20.59689183
85SGK10.59340836
86PINK10.57834002
87PRKCH0.56980879
88PKN10.54399348
89RAF10.53779516
90MAPK100.53595783
91FGFR20.52995304
92MARK20.52390195
93PDPK10.52368423
94MAP2K60.50528659
95PBK0.48965193
96FRK0.47376463
97ROCK20.47093625
98LMTK20.45645030
99CAMK2G0.43886952
100SIK30.42951399
101RPS6KA30.42807192
102MAP3K10.42321622
103CAMK40.41889730
104MAP2K10.41680947
105CSNK1E0.41090133
106PRKG10.40788772
107CAMK1G0.40785760
108FYN0.38734044
109PRKCA0.38175679
110ERBB30.37959922
111DYRK20.36788268
112FER0.36485762
113TSSK60.36099144
114MAP3K70.35742086
115IRAK20.35723641
116WNK10.35584905
117CSNK1G30.35364702
118CSNK1G10.35151652
119CSNK1D0.34973206
120CAMK2D0.34541772
121RPS6KA20.34395870
122BRAF0.34128891
123TAF10.34071079
124MAP4K20.33883725
125DAPK30.33021699
126PRKCB0.32914347
127MKNK10.32798195
128WNK30.32692500
129PRKACA0.30715195

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.54300722
2Nicotine addiction_Homo sapiens_hsa050333.51706062
3GABAergic synapse_Homo sapiens_hsa047272.69797021
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54098947
5Olfactory transduction_Homo sapiens_hsa047402.48919753
6Circadian entrainment_Homo sapiens_hsa047132.35455885
7Morphine addiction_Homo sapiens_hsa050322.33432866
8Long-term potentiation_Homo sapiens_hsa047202.27728921
9Glutamatergic synapse_Homo sapiens_hsa047242.21840797
10Amphetamine addiction_Homo sapiens_hsa050312.15350818
11Vitamin B6 metabolism_Homo sapiens_hsa007502.10085379
12Dopaminergic synapse_Homo sapiens_hsa047281.97016815
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96685251
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95020481
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90113641
16Nitrogen metabolism_Homo sapiens_hsa009101.88465812
17Salivary secretion_Homo sapiens_hsa049701.80032753
18Insulin secretion_Homo sapiens_hsa049111.77567556
19Collecting duct acid secretion_Homo sapiens_hsa049661.73374163
20Butanoate metabolism_Homo sapiens_hsa006501.63892247
21Cholinergic synapse_Homo sapiens_hsa047251.60297703
22Taste transduction_Homo sapiens_hsa047421.60239666
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.58728927
24Renin secretion_Homo sapiens_hsa049241.54859968
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51201348
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49220975
27Serotonergic synapse_Homo sapiens_hsa047261.47515499
28Gastric acid secretion_Homo sapiens_hsa049711.42922794
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42111916
30Long-term depression_Homo sapiens_hsa047301.36859582
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35900665
32Cocaine addiction_Homo sapiens_hsa050301.35551827
33Arginine biosynthesis_Homo sapiens_hsa002201.33942132
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31806419
35Oxytocin signaling pathway_Homo sapiens_hsa049211.30188029
36Calcium signaling pathway_Homo sapiens_hsa040201.27905156
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11891874
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11091175
39Bile secretion_Homo sapiens_hsa049761.09473753
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08866144
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04787032
42GnRH signaling pathway_Homo sapiens_hsa049121.03791869
43Gap junction_Homo sapiens_hsa045400.98820766
44Type II diabetes mellitus_Homo sapiens_hsa049300.97656210
45Estrogen signaling pathway_Homo sapiens_hsa049150.95738458
46cAMP signaling pathway_Homo sapiens_hsa040240.93791931
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92324827
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91621155
49Axon guidance_Homo sapiens_hsa043600.90751132
50Vibrio cholerae infection_Homo sapiens_hsa051100.86093044
51Glioma_Homo sapiens_hsa052140.82715550
52ErbB signaling pathway_Homo sapiens_hsa040120.79328076
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75855384
54Glucagon signaling pathway_Homo sapiens_hsa049220.74964804
55Phototransduction_Homo sapiens_hsa047440.74877620
56Melanogenesis_Homo sapiens_hsa049160.74560051
57Cardiac muscle contraction_Homo sapiens_hsa042600.74492287
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74254646
59Pyruvate metabolism_Homo sapiens_hsa006200.73066403
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71009244
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70720613
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.66989772
63Dorso-ventral axis formation_Homo sapiens_hsa043200.66353582
64Parkinsons disease_Homo sapiens_hsa050120.65854189
65Type I diabetes mellitus_Homo sapiens_hsa049400.62839125
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61851877
67Prion diseases_Homo sapiens_hsa050200.57812439
68Oocyte meiosis_Homo sapiens_hsa041140.57320600
69Thyroid hormone synthesis_Homo sapiens_hsa049180.55201006
70Folate biosynthesis_Homo sapiens_hsa007900.54901423
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53978136
72Mineral absorption_Homo sapiens_hsa049780.53922533
73Inositol phosphate metabolism_Homo sapiens_hsa005620.51728990
74Wnt signaling pathway_Homo sapiens_hsa043100.50392631
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50015970
76Complement and coagulation cascades_Homo sapiens_hsa046100.49471491
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49019881
78Arginine and proline metabolism_Homo sapiens_hsa003300.47762034
79Fatty acid elongation_Homo sapiens_hsa000620.45970119
80Rap1 signaling pathway_Homo sapiens_hsa040150.44902239
81Histidine metabolism_Homo sapiens_hsa003400.44137639
82beta-Alanine metabolism_Homo sapiens_hsa004100.43922803
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43386876
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43065281
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.42222752
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41924509
87Regulation of autophagy_Homo sapiens_hsa041400.41407429
88Propanoate metabolism_Homo sapiens_hsa006400.41017891
89Alzheimers disease_Homo sapiens_hsa050100.40877275
90Fatty acid biosynthesis_Homo sapiens_hsa000610.40743201
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40569851
92Insulin signaling pathway_Homo sapiens_hsa049100.40055579
93Pancreatic secretion_Homo sapiens_hsa049720.39359808
94Dilated cardiomyopathy_Homo sapiens_hsa054140.39305983
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38845097
96MAPK signaling pathway_Homo sapiens_hsa040100.37830248
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37781006
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37745683
99Choline metabolism in cancer_Homo sapiens_hsa052310.35402218
100Tryptophan metabolism_Homo sapiens_hsa003800.34896126
101Oxidative phosphorylation_Homo sapiens_hsa001900.33101005
102Ras signaling pathway_Homo sapiens_hsa040140.32518502
103Circadian rhythm_Homo sapiens_hsa047100.32483789
104PPAR signaling pathway_Homo sapiens_hsa033200.31941909
105Tight junction_Homo sapiens_hsa045300.30771524
106Hippo signaling pathway_Homo sapiens_hsa043900.30483199
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29465803
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.29422163
109Fatty acid metabolism_Homo sapiens_hsa012120.29228854
110Alcoholism_Homo sapiens_hsa050340.27297472
111African trypanosomiasis_Homo sapiens_hsa051430.26747268
112Huntingtons disease_Homo sapiens_hsa050160.26539608
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.26495360
114Ovarian steroidogenesis_Homo sapiens_hsa049130.26483695
115Protein export_Homo sapiens_hsa030600.26419985
116Phenylalanine metabolism_Homo sapiens_hsa003600.26141055
117Glycerolipid metabolism_Homo sapiens_hsa005610.25463378
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25219627
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25031847
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24529760

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