NDUFV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.89242335
2ATP synthesis coupled proton transport (GO:0015986)9.13449118
3energy coupled proton transport, down electrochemical gradient (GO:0015985)9.13449118
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.56054063
5* respiratory electron transport chain (GO:0022904)8.11990412
6* electron transport chain (GO:0022900)7.92081010
7tricarboxylic acid cycle (GO:0006099)6.40100891
8oxidative phosphorylation (GO:0006119)6.39761638
9protein complex biogenesis (GO:0070271)5.49844317
10ATP biosynthetic process (GO:0006754)5.40978414
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.39509080
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.39509080
13NADH dehydrogenase complex assembly (GO:0010257)5.39509080
14mitochondrial respiratory chain complex assembly (GO:0033108)5.15580107
15NADH metabolic process (GO:0006734)5.13807482
16purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.92360448
17purine nucleoside triphosphate biosynthetic process (GO:0009145)4.87639689
18chaperone-mediated protein transport (GO:0072321)4.87062175
19hydrogen ion transmembrane transport (GO:1902600)4.80552823
20regulation of mitochondrial translation (GO:0070129)4.61032262
21succinate metabolic process (GO:0006105)4.58889769
22regulation of acyl-CoA biosynthetic process (GO:0050812)4.58865665
23aerobic respiration (GO:0009060)4.57393407
24inner mitochondrial membrane organization (GO:0007007)4.53305705
25regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.49423092
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.37664897
27ribonucleoside triphosphate biosynthetic process (GO:0009201)4.36837339
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.34958068
29regulation of cofactor metabolic process (GO:0051193)4.28103910
30regulation of coenzyme metabolic process (GO:0051196)4.28103910
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.25686251
32negative regulation of ligase activity (GO:0051352)4.25686251
33proton transport (GO:0015992)4.19470091
34establishment of protein localization to mitochondrial membrane (GO:0090151)4.17278456
35hydrogen transport (GO:0006818)4.12618062
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.09187393
37rRNA modification (GO:0000154)4.05581679
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.03647873
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.00653406
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.00653406
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.00653406
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.00118582
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.00118582
44ubiquinone biosynthetic process (GO:0006744)3.97751095
45quinone biosynthetic process (GO:1901663)3.97751095
46regulation of oxidative phosphorylation (GO:0002082)3.96519242
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.87708339
48nucleoside triphosphate biosynthetic process (GO:0009142)3.85062409
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.84407564
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.84407564
51cullin deneddylation (GO:0010388)3.84097099
52positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78937025
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.78905056
54respiratory chain complex IV assembly (GO:0008535)3.76725733
55regulation of cellular respiration (GO:0043457)3.76545212
56protein neddylation (GO:0045116)3.74464932
57oxaloacetate metabolic process (GO:0006107)3.74039545
58positive regulation of ligase activity (GO:0051351)3.72211567
59cellular respiration (GO:0045333)3.68543579
60termination of RNA polymerase III transcription (GO:0006386)3.68065411
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.68065411
62cytochrome complex assembly (GO:0017004)3.65136684
63purine nucleoside monophosphate biosynthetic process (GO:0009127)3.64637737
64purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.64637737
65heart process (GO:0003015)3.60323695
66heart contraction (GO:0060047)3.60323695
67sarcomere organization (GO:0045214)3.56098947
68mitochondrial transport (GO:0006839)3.55421911
69ubiquinone metabolic process (GO:0006743)3.54475547
70regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.54325790
71protein deneddylation (GO:0000338)3.49137640
72DNA deamination (GO:0045006)3.47578936
73pseudouridine synthesis (GO:0001522)3.46794775
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.45702729
75protein targeting to mitochondrion (GO:0006626)3.39594871
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.37760861
77ATP hydrolysis coupled proton transport (GO:0015991)3.37760861
78regulation of cell communication by electrical coupling (GO:0010649)3.37577206
79muscle filament sliding (GO:0030049)3.36999255
80actin-myosin filament sliding (GO:0033275)3.36999255
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35893025
82rRNA methylation (GO:0031167)3.35164477
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35139942
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34692883
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34692883
86regulation of ligase activity (GO:0051340)3.34486111
87establishment of protein localization to mitochondrion (GO:0072655)3.33009654
88* generation of precursor metabolites and energy (GO:0006091)3.30362620
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.29239205
90regulation of cellular amine metabolic process (GO:0033238)3.28457404
91protein localization to mitochondrion (GO:0070585)3.27124285
92regulation of sulfur metabolic process (GO:0042762)3.25107988
93cardiac muscle contraction (GO:0060048)3.22253305
94GTP biosynthetic process (GO:0006183)3.22197566
95cardiac myofibril assembly (GO:0055003)3.21711301
96proteasome assembly (GO:0043248)3.20970549
97ribosomal small subunit assembly (GO:0000028)3.20181114
98regulation of relaxation of muscle (GO:1901077)3.19082357
99translation (GO:0006412)3.16078887
100maturation of 5.8S rRNA (GO:0000460)3.15610965
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15406085
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.15239039
103ribosome assembly (GO:0042255)3.09016699
104DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06999969
105purine ribonucleoside biosynthetic process (GO:0046129)3.06663434
106purine nucleoside biosynthetic process (GO:0042451)3.06663434
107positive regulation of cell cycle arrest (GO:0071158)3.05793554
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05223860
109water-soluble vitamin biosynthetic process (GO:0042364)3.02914885
110CENP-A containing nucleosome assembly (GO:0034080)3.02546073
111purine nucleobase biosynthetic process (GO:0009113)3.01991815
112chromatin remodeling at centromere (GO:0031055)3.01298200
113ribosomal large subunit biogenesis (GO:0042273)3.01222200
114protein-cofactor linkage (GO:0018065)3.01089945
115myofibril assembly (GO:0030239)2.99429490
116regulation of cellular amino acid metabolic process (GO:0006521)2.98067211
117ribonucleoside monophosphate biosynthetic process (GO:0009156)2.96892377
118negative regulation of protein ubiquitination (GO:0031397)2.95841936
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94941255
120establishment of integrated proviral latency (GO:0075713)2.91229051
121negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89287044
122cellular component biogenesis (GO:0044085)2.87573764
123branched-chain amino acid catabolic process (GO:0009083)2.85216851
124DNA double-strand break processing (GO:0000729)2.84998273
125peptidyl-histidine modification (GO:0018202)2.83855429
126regulation of actin filament-based movement (GO:1903115)2.82340580
127rRNA processing (GO:0006364)2.82012125
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81800888
129maturation of SSU-rRNA (GO:0030490)2.81271856
130regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.80438738
131nucleoside monophosphate biosynthetic process (GO:0009124)2.80402412
132cotranslational protein targeting to membrane (GO:0006613)2.79340085
133negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.79259188
134DNA damage response, detection of DNA damage (GO:0042769)2.78708342
135antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78225723
136aspartate family amino acid catabolic process (GO:0009068)2.78212438
137nucleobase biosynthetic process (GO:0046112)2.77628790
138spliceosomal snRNP assembly (GO:0000387)2.76787330
139guanosine-containing compound biosynthetic process (GO:1901070)2.76139555
140protein targeting to ER (GO:0045047)2.76075227
141metallo-sulfur cluster assembly (GO:0031163)2.75150936
142iron-sulfur cluster assembly (GO:0016226)2.75150936
143telomere maintenance via semi-conservative replication (GO:0032201)2.74648510
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72317884
145regulation of sarcomere organization (GO:0060297)2.67897491
146actin-mediated cell contraction (GO:0070252)2.67488008
147quinone metabolic process (GO:1901661)2.66354474
148regulation of skeletal muscle contraction (GO:0014819)2.65195170
149cellular ketone body metabolic process (GO:0046950)2.65177717
150ribonucleoside biosynthetic process (GO:0042455)2.64056811
151sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63646162
152UTP biosynthetic process (GO:0006228)2.62367663
153intracellular protein transmembrane import (GO:0044743)2.60412567
154striated muscle contraction (GO:0006941)2.60282162
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.60171015
156dopamine transport (GO:0015872)2.58640702
157negative regulation of potassium ion transmembrane transport (GO:1901380)2.58421010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84426189
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.80487292
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78993477
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.68344242
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.64573424
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54478703
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33338622
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25290490
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22152481
10E2F7_22180533_ChIP-Seq_HELA_Human3.20463966
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.15986967
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15669107
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11490532
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97897621
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93451782
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91385523
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.81444182
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75821573
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.71637748
20EZH2_22144423_ChIP-Seq_EOC_Human2.67406630
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.62022119
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.59543266
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57363303
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23675127
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.20893760
26DCP1A_22483619_ChIP-Seq_HELA_Human2.09545087
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03179829
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02544034
29VDR_23849224_ChIP-Seq_CD4+_Human1.89579770
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88697753
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79480054
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78040619
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72527490
34VDR_22108803_ChIP-Seq_LS180_Human1.67701848
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65193969
36FOXP3_21729870_ChIP-Seq_TREG_Human1.61349242
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60914554
38TAF15_26573619_Chip-Seq_HEK293_Human1.57815615
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.55328098
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49650933
41GABP_19822575_ChIP-Seq_HepG2_Human1.48594807
42XRN2_22483619_ChIP-Seq_HELA_Human1.48208421
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43797377
44GBX2_23144817_ChIP-Seq_PC3_Human1.42873474
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42045378
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41851552
47TTF2_22483619_ChIP-Seq_HELA_Human1.38628060
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37993084
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36351925
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34947226
51ELK1_19687146_ChIP-ChIP_HELA_Human1.33142540
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32846621
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.30941264
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30198719
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26501553
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23298734
57* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20515023
58KDM5A_27292631_Chip-Seq_BREAST_Human1.19827910
59AR_21909140_ChIP-Seq_LNCAP_Human1.19671688
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19626573
61IGF1R_20145208_ChIP-Seq_DFB_Human1.19585177
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16694638
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.14736041
64MYC_18940864_ChIP-ChIP_HL60_Human1.14610912
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13261595
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12888829
67EWS_26573619_Chip-Seq_HEK293_Human1.11258877
68FUS_26573619_Chip-Seq_HEK293_Human1.10344960
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10330710
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02653358
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01597653
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99397091
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99143464
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98783405
75FOXM1_23109430_ChIP-Seq_U2OS_Human0.98072970
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97662088
77GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96335676
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.96279587
79HTT_18923047_ChIP-ChIP_STHdh_Human0.95998460
80* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95233890
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93584709
82ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92479253
83ZNF274_21170338_ChIP-Seq_K562_Hela0.92006173
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.91595515
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90848710
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90583435
87IRF1_19129219_ChIP-ChIP_H3396_Human0.90302575
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88825444
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88302772
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88020264
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87403041
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86889934
93* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85897851
94REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85520842
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84860099
96* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84553401
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83845751
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83616196
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.83235057
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82143072
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81134862
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79678463
103* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79605918
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78685458
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.78417823
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78270361
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.78041676
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.78025836
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77644536
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76880984
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76820354
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.76721017
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76583268
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75957756
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75822171
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75656808
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.74231982
118ERG_20517297_ChIP-Seq_VCAP_Human0.73789704
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73448839
120* NANOG_19829295_ChIP-Seq_ESCs_Human0.72955679
121* SOX2_19829295_ChIP-Seq_ESCs_Human0.72955679
122TP53_22573176_ChIP-Seq_HFKS_Human0.72852292
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72717058
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72432016
125RBPJ_21746931_ChIP-Seq_IB4_Human0.72426262
126TFEB_21752829_ChIP-Seq_HELA_Human0.72179977
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.71666141
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71436987
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71099806
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71098321
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70452035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.71813057
2MP0003646_muscle_fatigue5.21461509
3MP0000751_myopathy3.85809908
4MP0004215_abnormal_myocardial_fiber3.84019471
5MP0004084_abnormal_cardiac_muscle3.48133887
6MP0006036_abnormal_mitochondrial_physio3.45658960
7MP0008058_abnormal_DNA_repair3.37144350
8MP0004036_abnormal_muscle_relaxation3.24505634
9MP0000749_muscle_degeneration3.13123733
10MP0001529_abnormal_vocalization2.96869335
11MP0005330_cardiomyopathy2.66435751
12MP0010094_abnormal_chromosome_stability2.63761147
13MP0003693_abnormal_embryo_hatching2.62778679
14MP0003880_abnormal_central_pattern2.60758527
15MP0004957_abnormal_blastocyst_morpholog2.58568399
16MP0006035_abnormal_mitochondrial_morpho2.42736491
17MP0003786_premature_aging2.35551519
18MP0003137_abnormal_impulse_conducting2.23974104
19MP0003718_maternal_effect2.19339580
20MP0004145_abnormal_muscle_electrophysio2.14127570
21MP0002972_abnormal_cardiac_muscle2.10862336
22MP0003806_abnormal_nucleotide_metabolis2.08376919
23MP0005620_abnormal_muscle_contractility1.95955975
24MP0004043_abnormal_pH_regulation1.95708683
25MP0008877_abnormal_DNA_methylation1.94542118
26MP0003111_abnormal_nucleus_morphology1.93939115
27MP0009379_abnormal_foot_pigmentation1.93337218
28MP0008007_abnormal_cellular_replicative1.88619321
29MP0004484_altered_response_of1.87243319
30MP0008775_abnormal_heart_ventricle1.85809448
31MP0003077_abnormal_cell_cycle1.78669750
32MP0006276_abnormal_autonomic_nervous1.77088740
33MP0002106_abnormal_muscle_physiology1.72221968
34MP0006292_abnormal_olfactory_placode1.67550550
35MP0002736_abnormal_nociception_after1.67139864
36MP0008995_early_reproductive_senescence1.64609007
37MP0001905_abnormal_dopamine_level1.62689046
38MP0005385_cardiovascular_system_phenoty1.62170379
39MP0001544_abnormal_cardiovascular_syste1.62170379
40MP0004087_abnormal_muscle_fiber1.59766612
41MP0004085_abnormal_heartbeat1.59689300
42MP0004142_abnormal_muscle_tone1.58006529
43MP0002332_abnormal_exercise_endurance1.57954402
44MP0008932_abnormal_embryonic_tissue1.56926459
45MP0004147_increased_porphyrin_level1.56572151
46MP0005408_hypopigmentation1.52374978
47MP0009046_muscle_twitch1.51789705
48MP0002102_abnormal_ear_morphology1.50488518
49MP0000750_abnormal_muscle_regeneration1.49806356
50MP0002938_white_spotting1.48006803
51MP0003221_abnormal_cardiomyocyte_apopto1.45891172
52MP0002269_muscular_atrophy1.44331287
53MP0002272_abnormal_nervous_system1.43395236
54MP0006138_congestive_heart_failure1.42799129
55MP0005369_muscle_phenotype1.42211571
56MP0009745_abnormal_behavioral_response1.41480103
57MP0002822_catalepsy1.40778238
58MP0004130_abnormal_muscle_cell1.40731144
59MP0000747_muscle_weakness1.37058858
60MP0001968_abnormal_touch/_nociception1.36933397
61MP0009697_abnormal_copulation1.33809570
62MP0008057_abnormal_DNA_replication1.32298636
63MP0005266_abnormal_metabolism1.31175909
64MP0002064_seizures1.26788158
65MP0003941_abnormal_skin_development1.26339355
66MP0003186_abnormal_redox_activity1.25979985
67MP0003011_delayed_dark_adaptation1.23433043
68MP0004233_abnormal_muscle_weight1.22747316
69MP0000759_abnormal_skeletal_muscle1.22611140
70MP0004924_abnormal_behavior1.22435557
71MP0005386_behavior/neurological_phenoty1.22435557
72MP0003567_abnormal_fetal_cardiomyocyte1.18927033
73MP0005379_endocrine/exocrine_gland_phen1.18407127
74MP0002876_abnormal_thyroid_physiology1.17711885
75MP0002735_abnormal_chemical_nociception1.16471580
76MP0002127_abnormal_cardiovascular_syste1.15530007
77MP0003635_abnormal_synaptic_transmissio1.13230592
78MP0002638_abnormal_pupillary_reflex1.11835885
79MP0008789_abnormal_olfactory_epithelium1.08505116
80MP0001440_abnormal_grooming_behavior1.05065409
81MP0002160_abnormal_reproductive_system1.03461769
82MP0000230_abnormal_systemic_arterial1.03209422
83MP0001984_abnormal_olfaction1.02745351
84MP0002090_abnormal_vision1.01936581
85MP0003195_calcinosis1.01661413
86MP0002572_abnormal_emotion/affect_behav1.00313099
87MP0002067_abnormal_sensory_capabilities1.00209161
88MP0005253_abnormal_eye_physiology0.99761929
89MP0005332_abnormal_amino_acid0.99094309
90MP0001929_abnormal_gametogenesis0.97921677
91MP0002139_abnormal_hepatobiliary_system0.97477869
92MP0005075_abnormal_melanosome_morpholog0.96394505
93MP0000013_abnormal_adipose_tissue0.95814840
94MP0005535_abnormal_body_temperature0.95737749
95MP0002210_abnormal_sex_determination0.94551834
96MP0002734_abnormal_mechanical_nocicepti0.93296000
97MP0010630_abnormal_cardiac_muscle0.92881652
98MP0005636_abnormal_mineral_homeostasis0.92726357
99MP0003122_maternal_imprinting0.91086594
100MP0004270_analgesia0.90985574
101MP0002063_abnormal_learning/memory/cond0.90857139
102MP0001485_abnormal_pinna_reflex0.88642361
103MP0001764_abnormal_homeostasis0.87889434
104MP0005551_abnormal_eye_electrophysiolog0.87810612
105MP0002277_abnormal_respiratory_mucosa0.87680880
106MP0005584_abnormal_enzyme/coenzyme_acti0.87151282
107MP0005646_abnormal_pituitary_gland0.85488416
108MP0005365_abnormal_bile_salt0.84090390
109MP0008872_abnormal_physiological_respon0.81690034
110MP0001501_abnormal_sleep_pattern0.81281707
111MP0001293_anophthalmia0.79932141
112MP0001661_extended_life_span0.79676863
113MP0001986_abnormal_taste_sensitivity0.77787163
114MP0000653_abnormal_sex_gland0.77607456
115MP0001145_abnormal_male_reproductive0.76053922
116MP0005389_reproductive_system_phenotype0.75762536
117MP0005084_abnormal_gallbladder_morpholo0.73976385
118MP0005410_abnormal_fertilization0.72764135
119MP0001970_abnormal_pain_threshold0.72738624
120MP0005376_homeostasis/metabolism_phenot0.72516329
121MP0005670_abnormal_white_adipose0.72128697
122MP0005085_abnormal_gallbladder_physiolo0.72086607
123MP0002234_abnormal_pharynx_morphology0.72061046
124MP0005165_increased_susceptibility_to0.71705718
125MP0002138_abnormal_hepatobiliary_system0.71598242
126MP0002132_abnormal_respiratory_system0.70645071
127MP0003123_paternal_imprinting0.68705532
128MP0008875_abnormal_xenobiotic_pharmacok0.67914529
129MP0003656_abnormal_erythrocyte_physiolo0.67793191
130MP0000372_irregular_coat_pigmentation0.67649063
131MP0001486_abnormal_startle_reflex0.66470483
132MP0003787_abnormal_imprinting0.66416720
133MP0005423_abnormal_somatic_nervous0.66361721
134MP0002163_abnormal_gland_morphology0.66003593
135MP0001697_abnormal_embryo_size0.65786546
136MP0001188_hyperpigmentation0.65054327
137MP0002066_abnormal_motor_capabilities/c0.64624779
138MP0002095_abnormal_skin_pigmentation0.64429985
139MP0005319_abnormal_enzyme/_coenzyme0.63875296
140MP0002693_abnormal_pancreas_physiology0.63224763
141MP0004019_abnormal_vitamin_homeostasis0.62970448
142MP0003121_genomic_imprinting0.62686865
143MP0004859_abnormal_synaptic_plasticity0.62675371
144MP0006072_abnormal_retinal_apoptosis0.61237885
145MP0003136_yellow_coat_color0.60696119
146MP0001727_abnormal_embryo_implantation0.60135191
147MP0005645_abnormal_hypothalamus_physiol0.59898590
148MP0000358_abnormal_cell_content/0.56957726

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)6.90961911
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.64129849
3* Mitochondrial inheritance (HP:0001427)6.31968884
4Hepatocellular necrosis (HP:0001404)6.11247483
5* Acute encephalopathy (HP:0006846)5.94478366
6Hepatic necrosis (HP:0002605)5.80157759
7* Progressive macrocephaly (HP:0004481)5.75865042
8* Increased CSF lactate (HP:0002490)5.73713116
9Increased serum pyruvate (HP:0003542)4.78752605
10Abnormality of glycolysis (HP:0004366)4.78752605
11Increased hepatocellular lipid droplets (HP:0006565)4.56521258
12Lipid accumulation in hepatocytes (HP:0006561)4.43477202
13* Cerebral edema (HP:0002181)4.42418910
14Increased intramyocellular lipid droplets (HP:0012240)4.35043784
15* Lactic acidosis (HP:0003128)4.30069097
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.25692122
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.25692122
18Increased muscle lipid content (HP:0009058)4.13560020
19* Exercise intolerance (HP:0003546)4.05213831
20* Respiratory failure (HP:0002878)4.02171523
21Increased serum lactate (HP:0002151)3.93813621
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.86158989
23Sudden death (HP:0001699)3.73550134
24Renal Fanconi syndrome (HP:0001994)3.57105005
25Calf muscle hypertrophy (HP:0008981)3.53872208
26* Optic disc pallor (HP:0000543)3.48376951
27Muscle hypertrophy of the lower extremities (HP:0008968)3.44408511
28Neuroendocrine neoplasm (HP:0100634)3.43665104
29Pheochromocytoma (HP:0002666)3.40326906
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.31125174
31Palpitations (HP:0001962)3.29059187
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19355255
33Abnormality of alanine metabolism (HP:0010916)3.19355255
34Hyperalaninemia (HP:0003348)3.19355255
35* Leukodystrophy (HP:0002415)3.17397788
36Exercise-induced myalgia (HP:0003738)3.12683756
37Exercise-induced muscle cramps (HP:0003710)3.12436080
38Myoglobinuria (HP:0002913)3.09154530
39CNS demyelination (HP:0007305)2.96459311
403-Methylglutaconic aciduria (HP:0003535)2.89298459
41Respiratory difficulties (HP:0002880)2.84768744
42Type I transferrin isoform profile (HP:0003642)2.79592755
43Ventricular tachycardia (HP:0004756)2.77322996
44Ragged-red muscle fibers (HP:0003200)2.77269002
45Exertional dyspnea (HP:0002875)2.75569298
46Rhabdomyolysis (HP:0003201)2.73838035
47Conjunctival hamartoma (HP:0100780)2.68990559
48* Lethargy (HP:0001254)2.66527900
49Dicarboxylic aciduria (HP:0003215)2.61700641
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61700641
51Emotional lability (HP:0000712)2.61251722
52Abnormality of the calf musculature (HP:0001430)2.56763044
53Abnormality of the anterior horn cell (HP:0006802)2.54789330
54Degeneration of anterior horn cells (HP:0002398)2.54789330
55Atrial fibrillation (HP:0005110)2.54285042
56Glycosuria (HP:0003076)2.49954235
57Abnormality of urine glucose concentration (HP:0011016)2.49954235
58Abnormality of methionine metabolism (HP:0010901)2.46190153
59Supraventricular tachycardia (HP:0004755)2.44768388
60Abnormality of renal resorption (HP:0011038)2.42830223
61Lipoatrophy (HP:0100578)2.40370866
62Primary atrial arrhythmia (HP:0001692)2.39965319
63Aplastic anemia (HP:0001915)2.37815571
64Abnormality of the labia minora (HP:0012880)2.35752007
65Supraventricular arrhythmia (HP:0005115)2.35339581
66Esophageal neoplasm (HP:0100751)2.33600693
67Neoplasm of head and neck (HP:0012288)2.33600693
68Methylmalonic aciduria (HP:0012120)2.31975889
69Abnormality of fatty-acid metabolism (HP:0004359)2.30904538
70Reticulocytopenia (HP:0001896)2.29903857
71Ketoacidosis (HP:0001993)2.29056494
72Reduced antithrombin III activity (HP:0001976)2.28903663
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25229617
74Abnormal protein N-linked glycosylation (HP:0012347)2.25229617
75Abnormal protein glycosylation (HP:0012346)2.25229617
76Abnormal glycosylation (HP:0012345)2.25229617
77Syncope (HP:0001279)2.24204919
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21799453
79Gliosis (HP:0002171)2.21467978
80Dilated cardiomyopathy (HP:0001644)2.19682485
81Muscle fiber inclusion bodies (HP:0100299)2.18746666
82Abnormality of serum amino acid levels (HP:0003112)2.18633026
83Myotonia (HP:0002486)2.18115920
84Nemaline bodies (HP:0003798)2.16102356
85Hyperglycinemia (HP:0002154)2.13950598
86* X-linked dominant inheritance (HP:0001423)2.13793250
87Generalized aminoaciduria (HP:0002909)2.13386269
88Prolonged QT interval (HP:0001657)2.13252406
89Hyperphosphaturia (HP:0003109)2.12998717
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12027035
91Cerebral hypomyelination (HP:0006808)2.11835312
92Colon cancer (HP:0003003)2.10160152
93Macrocytic anemia (HP:0001972)2.09624509
94Pancytopenia (HP:0001876)2.05462025
95Neoplasm of the adrenal gland (HP:0100631)2.03506868
96Microvesicular hepatic steatosis (HP:0001414)2.03481895
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03170102
98* Vomiting (HP:0002013)2.02401440
99Muscle fiber splitting (HP:0003555)2.00487945
100Methylmalonic acidemia (HP:0002912)1.96898009
101Hyperglycinuria (HP:0003108)1.95731161
102Meckel diverticulum (HP:0002245)1.95139179
103Ventricular fibrillation (HP:0001663)1.94291014
104Muscle stiffness (HP:0003552)1.93660063
105Abnormality of cells of the erythroid lineage (HP:0012130)1.93351898
106Pancreatic cysts (HP:0001737)1.92777638
107Metabolic acidosis (HP:0001942)1.92625638
108Pancreatic fibrosis (HP:0100732)1.92595407
109Left ventricular hypertrophy (HP:0001712)1.92573704
110Renal cortical cysts (HP:0000803)1.90099636
111Abnormal number of erythroid precursors (HP:0012131)1.89366820
112EMG: myopathic abnormalities (HP:0003458)1.88573570
113Hypothermia (HP:0002045)1.88188577
114Abnormality of the ileum (HP:0001549)1.87388832
115Nausea (HP:0002018)1.86188416
116Ketosis (HP:0001946)1.84981707
117Hyperventilation (HP:0002883)1.83311303
118Neoplasm of the peripheral nervous system (HP:0100007)1.82111766
119Focal motor seizures (HP:0011153)1.82025303
120Type 2 muscle fiber atrophy (HP:0003554)1.79984263
121Oral leukoplakia (HP:0002745)1.79365141
122Abnormality of the preputium (HP:0100587)1.79178326
123Hypoglycemic coma (HP:0001325)1.79101810
124Abnormality of serine family amino acid metabolism (HP:0010894)1.78597085
125Abnormality of glycine metabolism (HP:0010895)1.78597085
126Unsteady gait (HP:0002317)1.78442770
127Rimmed vacuoles (HP:0003805)1.78436086
128Progressive external ophthalmoplegia (HP:0000590)1.77727839
129True hermaphroditism (HP:0010459)1.74367628
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.73986635
131Abnormal urine phosphate concentration (HP:0012599)1.73966167
132Molar tooth sign on MRI (HP:0002419)1.73262318
133Abnormality of midbrain morphology (HP:0002418)1.73262318
134Ventricular arrhythmia (HP:0004308)1.72477844
135Abnormal EKG (HP:0003115)1.71998455
136Hyperammonemia (HP:0001987)1.68818963
137Chromsome breakage (HP:0040012)1.68089993
138Hyperinsulinemic hypoglycemia (HP:0000825)1.67347691
139Subaortic stenosis (HP:0001682)1.67271111
140Abnormality of the left ventricular outflow tract (HP:0011103)1.67271111
141Poor suck (HP:0002033)1.65922949
142Congenital, generalized hypertrichosis (HP:0004540)1.65660807
143Medial flaring of the eyebrow (HP:0010747)1.65465605
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64635633
145Cerebral hemorrhage (HP:0001342)1.64263134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.65911315
2PDK33.53525626
3PDK43.53525626
4NME13.41315169
5MAP3K123.38203670
6VRK23.30096842
7OBSCN3.15369673
8CASK2.81220000
9STK162.76532647
10BCKDK2.76305142
11NME22.25971056
12EIF2AK12.19828038
13NEK12.16850665
14PHKG12.12902848
15PHKG22.12902848
16WNK42.11110730
17CDC71.98440173
18PDK21.97656117
19MAP2K71.97404086
20LMTK21.96803300
21GRK71.88787906
22TLK11.85356789
23MUSK1.82116348
24TTK1.81044657
25PLK31.80608524
26CDK191.78460192
27NUAK11.73236233
28STK391.68555110
29MAP4K21.68110205
30PBK1.54709406
31OXSR11.50488935
32CCNB11.40798446
33TTN1.40527188
34TRIM281.40027636
35PLK41.38819218
36MAP3K41.37483457
37VRK11.33292209
38ARAF1.30251939
39PINK11.25200490
40BUB11.23792924
41PLK11.20676214
42LIMK11.20052409
43FRK1.19482762
44ILK1.15787936
45GRK11.14973024
46PIK3CA1.08659280
47MAP2K41.07784386
48MKNK11.07672564
49PLK21.05562696
50DAPK31.04416111
51BCR1.02799981
52STK241.00876092
53CAMK2D1.00446311
54TSSK60.99656274
55CSNK1G10.99520911
56BRAF0.99432545
57MST40.95838704
58DAPK10.94813435
59EIF2AK30.92304066
60TAF10.88406745
61CAMK2A0.87966684
62TNIK0.87162194
63SRPK10.86825213
64CSNK1G20.84376160
65NTRK30.84368754
66ERBB30.84174862
67AURKB0.83336074
68WNK30.79994914
69STK40.79282706
70GRK50.78135889
71ADRBK20.77054440
72WEE10.76314276
73CAMK2G0.75538144
74CSNK1A1L0.73029317
75MAP3K110.70220210
76CAMK2B0.70191036
77MINK10.68407506
78MAP2K60.67180125
79ATR0.66963292
80STK38L0.66084440
81ZAK0.66080205
82TXK0.66008000
83TIE10.63782309
84EIF2AK20.63526452
85INSRR0.63317760
86BMPR1B0.62007749
87CDK80.61746491
88KDR0.61689702
89EPHA40.60934429
90ADRBK10.60722039
91PRKACA0.59792772
92PRKCG0.59590053
93CHEK20.59077086
94PRKCE0.52066946
95ATM0.51231843
96AURKA0.48076809
97PRKCI0.47193341
98RPS6KA50.46510417
99MAPKAPK30.46140299
100ROCK20.45831246
101PNCK0.44965045
102TESK10.44728701
103ABL20.44179745
104MAPK130.44146295
105AKT30.44027288
106MAPK120.43350973
107PTK2B0.40734914
108CSNK2A10.39684031
109PKN10.38857973
110PIK3CG0.38626466
111PAK10.38614657
112CSNK1E0.37970724
113ROCK10.37717043
114PAK30.37062061
115CSNK1A10.36628491
116BMPR20.35905751
117CSNK2A20.35734636
118PASK0.35725220
119CLK10.35639663
120ACVR1B0.34586864
121STK30.34401130
122PRKACB0.34048171
123DYRK20.34034043
124TESK20.33954645
125CHEK10.33508677
126MAP3K50.32394303
127MARK30.31605477
128SCYL20.31512717
129ALK0.30549286
130NEK20.28648530
131CAMK10.27725718
132CSNK1G30.26566720
133MARK10.25671246
134UHMK10.25623837
135PRKCA0.24684661
136MKNK20.24496998
137BRSK20.23388627
138CDK140.23028420
139BRSK10.21782745
140PRKACG0.21502317

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.96256744
2Parkinsons disease_Homo sapiens_hsa050125.27402652
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.60327066
4Alzheimers disease_Homo sapiens_hsa050103.85292893
5Huntingtons disease_Homo sapiens_hsa050163.67527359
6Cardiac muscle contraction_Homo sapiens_hsa042603.28717196
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.20134217
8Proteasome_Homo sapiens_hsa030502.80550422
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.79960510
10Ribosome_Homo sapiens_hsa030102.52878913
11Propanoate metabolism_Homo sapiens_hsa006402.46115526
12Pyruvate metabolism_Homo sapiens_hsa006202.28912856
13Carbon metabolism_Homo sapiens_hsa012001.96894064
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78517684
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70883123
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69909953
17One carbon pool by folate_Homo sapiens_hsa006701.68188148
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66710390
19Collecting duct acid secretion_Homo sapiens_hsa049661.65473216
20Fatty acid elongation_Homo sapiens_hsa000621.61789705
21RNA polymerase_Homo sapiens_hsa030201.59634953
22Protein export_Homo sapiens_hsa030601.52369324
23Fatty acid degradation_Homo sapiens_hsa000711.49983708
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48986417
25Fanconi anemia pathway_Homo sapiens_hsa034601.43882632
26Butanoate metabolism_Homo sapiens_hsa006501.36851538
27Non-homologous end-joining_Homo sapiens_hsa034501.33203061
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22920430
29Fatty acid metabolism_Homo sapiens_hsa012121.17469333
30Vitamin B6 metabolism_Homo sapiens_hsa007501.13909077
31Biosynthesis of amino acids_Homo sapiens_hsa012301.03420319
32Vibrio cholerae infection_Homo sapiens_hsa051100.97035019
33Pyrimidine metabolism_Homo sapiens_hsa002400.95236114
34Sulfur metabolism_Homo sapiens_hsa009200.94143199
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.92056326
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.89133126
37* Metabolic pathways_Homo sapiens_hsa011000.89116308
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87620644
39Peroxisome_Homo sapiens_hsa041460.87266230
40Steroid biosynthesis_Homo sapiens_hsa001000.86675132
41Synaptic vesicle cycle_Homo sapiens_hsa047210.83097866
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81244368
43Nicotine addiction_Homo sapiens_hsa050330.80517683
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.78849910
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74378112
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73071871
47Dilated cardiomyopathy_Homo sapiens_hsa054140.72593323
48Purine metabolism_Homo sapiens_hsa002300.71651396
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71391837
50Phenylalanine metabolism_Homo sapiens_hsa003600.70713783
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70636994
52Selenocompound metabolism_Homo sapiens_hsa004500.70615376
53beta-Alanine metabolism_Homo sapiens_hsa004100.66105199
54DNA replication_Homo sapiens_hsa030300.64591907
55Caffeine metabolism_Homo sapiens_hsa002320.62085517
56Nitrogen metabolism_Homo sapiens_hsa009100.61724134
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.59572479
58Cell cycle_Homo sapiens_hsa041100.58250505
59Fructose and mannose metabolism_Homo sapiens_hsa000510.58204365
60Tyrosine metabolism_Homo sapiens_hsa003500.57606013
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57459902
62Glutathione metabolism_Homo sapiens_hsa004800.56170919
63Mismatch repair_Homo sapiens_hsa034300.54987243
64Retinol metabolism_Homo sapiens_hsa008300.54701467
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52606337
66Arginine and proline metabolism_Homo sapiens_hsa003300.51658838
67Pentose phosphate pathway_Homo sapiens_hsa000300.51327920
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50895618
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50495896
70Sulfur relay system_Homo sapiens_hsa041220.47886222
71Spliceosome_Homo sapiens_hsa030400.45964941
72Nucleotide excision repair_Homo sapiens_hsa034200.45127914
73Regulation of autophagy_Homo sapiens_hsa041400.43249089
74Oocyte meiosis_Homo sapiens_hsa041140.42968083
75Tryptophan metabolism_Homo sapiens_hsa003800.42714163
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41741224
77GABAergic synapse_Homo sapiens_hsa047270.41702690
78Homologous recombination_Homo sapiens_hsa034400.41538408
79Calcium signaling pathway_Homo sapiens_hsa040200.41310162
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40207802
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.39534488
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38689452
83Galactose metabolism_Homo sapiens_hsa000520.38652701
84N-Glycan biosynthesis_Homo sapiens_hsa005100.37972770
85Taste transduction_Homo sapiens_hsa047420.37257734
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36478322
87Fat digestion and absorption_Homo sapiens_hsa049750.35807005
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35028250
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34966522
90Folate biosynthesis_Homo sapiens_hsa007900.33363005
91RNA degradation_Homo sapiens_hsa030180.32908580
92mRNA surveillance pathway_Homo sapiens_hsa030150.32670541
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31174307
94PPAR signaling pathway_Homo sapiens_hsa033200.30067859
95Mineral absorption_Homo sapiens_hsa049780.29963471
96Morphine addiction_Homo sapiens_hsa050320.29943664
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28228843
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28068680
99Starch and sucrose metabolism_Homo sapiens_hsa005000.27815470
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27784375
101Circadian entrainment_Homo sapiens_hsa047130.27519222
102Glucagon signaling pathway_Homo sapiens_hsa049220.27063256
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26142118
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26004133
105Serotonergic synapse_Homo sapiens_hsa047260.25697693
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25043745
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23901827
108Linoleic acid metabolism_Homo sapiens_hsa005910.23374153
109Amphetamine addiction_Homo sapiens_hsa050310.22751206
110Circadian rhythm_Homo sapiens_hsa047100.21371077
111Basal transcription factors_Homo sapiens_hsa030220.21148910
112Arginine biosynthesis_Homo sapiens_hsa002200.20806460
113Dopaminergic synapse_Homo sapiens_hsa047280.18784510
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17476037
115Long-term potentiation_Homo sapiens_hsa047200.17445019
116Rheumatoid arthritis_Homo sapiens_hsa053230.17433263
117Renin secretion_Homo sapiens_hsa049240.17272831
118Vitamin digestion and absorption_Homo sapiens_hsa049770.16317207
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16250798
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15903004
121Systemic lupus erythematosus_Homo sapiens_hsa053220.15900397
122Epstein-Barr virus infection_Homo sapiens_hsa051690.15665423
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15462671
124p53 signaling pathway_Homo sapiens_hsa041150.15205442
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.13562283
126Olfactory transduction_Homo sapiens_hsa047400.13197923
127RNA transport_Homo sapiens_hsa030130.11617018
128Gastric acid secretion_Homo sapiens_hsa049710.11334861
129Arachidonic acid metabolism_Homo sapiens_hsa005900.10779118
130Base excision repair_Homo sapiens_hsa034100.10694712
131Chemical carcinogenesis_Homo sapiens_hsa052040.10055345
132Phototransduction_Homo sapiens_hsa047440.08131902

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