NDUFS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.67317249
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.67317249
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.60839241
4* respiratory electron transport chain (GO:0022904)7.99121935
5* electron transport chain (GO:0022900)7.78565974
6chaperone-mediated protein transport (GO:0072321)5.55947606
7ATP biosynthetic process (GO:0006754)5.25855972
8protein neddylation (GO:0045116)5.06211111
9purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.01963841
10purine nucleoside triphosphate biosynthetic process (GO:0009145)4.96985974
11* protein complex biogenesis (GO:0070271)4.87916381
12hydrogen ion transmembrane transport (GO:1902600)4.77016718
13* mitochondrial respiratory chain complex I assembly (GO:0032981)4.74220900
14* NADH dehydrogenase complex assembly (GO:0010257)4.74220900
15* mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74220900
16oxidative phosphorylation (GO:0006119)4.69249674
17ribosomal small subunit biogenesis (GO:0042274)4.68442703
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.52752184
19* mitochondrial respiratory chain complex assembly (GO:0033108)4.44408056
20viral transcription (GO:0019083)4.41527219
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.36346171
22inner mitochondrial membrane organization (GO:0007007)4.32279028
23translational termination (GO:0006415)4.24186086
24proton transport (GO:0015992)4.23901409
25GTP biosynthetic process (GO:0006183)4.18341382
26hydrogen transport (GO:0006818)4.16519400
27cotranslational protein targeting to membrane (GO:0006613)3.99447883
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90717430
29protein targeting to ER (GO:0045047)3.90664397
30nucleoside triphosphate biosynthetic process (GO:0009142)3.76935404
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76770203
32protein localization to endoplasmic reticulum (GO:0070972)3.75370861
33aerobic respiration (GO:0009060)3.63192286
34fatty acid elongation (GO:0030497)3.63009543
35regulation of mitochondrial translation (GO:0070129)3.52767672
36ribosomal small subunit assembly (GO:0000028)3.47907402
37translational elongation (GO:0006414)3.47431463
38cellular protein complex disassembly (GO:0043624)3.44317174
39mitochondrial transport (GO:0006839)3.41505992
40respiratory chain complex IV assembly (GO:0008535)3.41056765
41axon ensheathment in central nervous system (GO:0032291)3.38385238
42central nervous system myelination (GO:0022010)3.38385238
43viral life cycle (GO:0019058)3.38205103
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37176738
45UTP biosynthetic process (GO:0006228)3.36112601
46protein targeting to mitochondrion (GO:0006626)3.34740596
47cullin deneddylation (GO:0010388)3.34289252
48regulation of oxidative phosphorylation (GO:0002082)3.30458288
49tricarboxylic acid cycle (GO:0006099)3.30284921
50sequestering of actin monomers (GO:0042989)3.29807097
51platelet dense granule organization (GO:0060155)3.28286187
52establishment of protein localization to mitochondrion (GO:0072655)3.28119913
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27204190
54substantia nigra development (GO:0021762)3.26780783
55nonmotile primary cilium assembly (GO:0035058)3.25903886
56dopamine transport (GO:0015872)3.22448066
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21851325
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21851325
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20574986
60protein localization to mitochondrion (GO:0070585)3.11712554
61cytochrome complex assembly (GO:0017004)3.10754212
62water-soluble vitamin biosynthetic process (GO:0042364)3.09230908
63UTP metabolic process (GO:0046051)3.06186478
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.04199233
65ATP hydrolysis coupled proton transport (GO:0015991)3.04199233
66organelle disassembly (GO:1903008)3.03517769
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02795802
68purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.02121519
69purine nucleoside monophosphate biosynthetic process (GO:0009127)3.02121519
70aldehyde catabolic process (GO:0046185)3.02027906
71quinone biosynthetic process (GO:1901663)3.01413428
72ubiquinone biosynthetic process (GO:0006744)3.01413428
73proteasome assembly (GO:0043248)3.00718455
74protein deneddylation (GO:0000338)2.98954664
75ubiquinone metabolic process (GO:0006743)2.98070597
76regulation of cellular respiration (GO:0043457)2.98019217
77translation (GO:0006412)2.97515989
78regulation of cilium movement (GO:0003352)2.97279322
79chromatin remodeling at centromere (GO:0031055)2.96377621
80guanosine-containing compound biosynthetic process (GO:1901070)2.95956295
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94078124
82* generation of precursor metabolites and energy (GO:0006091)2.92464626
83protein-cofactor linkage (GO:0018065)2.90430351
84nuclear-transcribed mRNA catabolic process (GO:0000956)2.90109258
85CENP-A containing nucleosome assembly (GO:0034080)2.88529067
86negative regulation of ligase activity (GO:0051352)2.87478099
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87478099
88regulation of cellular amino acid metabolic process (GO:0006521)2.86337523
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85052533
90purine ribonucleoside biosynthetic process (GO:0046129)2.84458663
91purine nucleoside biosynthetic process (GO:0042451)2.84458663
92behavioral response to nicotine (GO:0035095)2.81229951
93intracellular protein transmembrane import (GO:0044743)2.80747577
94negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80595879
95* cellular component biogenesis (GO:0044085)2.79528806
96translational initiation (GO:0006413)2.78606732
97CTP metabolic process (GO:0046036)2.78466053
98CTP biosynthetic process (GO:0006241)2.78466053
99DNA damage response, detection of DNA damage (GO:0042769)2.78335957
100nucleoside diphosphate phosphorylation (GO:0006165)2.74116994
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73434493
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72068640
103mRNA catabolic process (GO:0006402)2.71991108
104protein complex disassembly (GO:0043241)2.70950947
105succinate metabolic process (GO:0006105)2.70836206
106cellular ketone body metabolic process (GO:0046950)2.69703516
107maturation of SSU-rRNA (GO:0030490)2.69390260
108cholesterol biosynthetic process (GO:0006695)2.69351802
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68566564
110* cellular respiration (GO:0045333)2.68531545
111signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65188462
112signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65188462
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65188462
114protein targeting to membrane (GO:0006612)2.65137460
115long-chain fatty acid biosynthetic process (GO:0042759)2.64702252
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63438993
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63438993
118mitochondrion morphogenesis (GO:0070584)2.62187457
119macromolecular complex disassembly (GO:0032984)2.61402952
120ribosomal large subunit biogenesis (GO:0042273)2.61234101
121establishment of integrated proviral latency (GO:0075713)2.60250660
122NADH metabolic process (GO:0006734)2.60114301
123transcription elongation from RNA polymerase III promoter (GO:0006385)2.60077892
124termination of RNA polymerase III transcription (GO:0006386)2.60077892
125quinone metabolic process (GO:1901661)2.59681857
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59480431
127epithelial cilium movement (GO:0003351)2.59384267
128ribonucleoprotein complex disassembly (GO:0032988)2.56529403
129intraciliary transport (GO:0042073)2.55723950
130heart process (GO:0003015)2.55561451
131heart contraction (GO:0060047)2.55561451
132regulation of acyl-CoA biosynthetic process (GO:0050812)2.54223413
133pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50910000
134neuron fate determination (GO:0048664)2.50829035
135signal transduction involved in cell cycle checkpoint (GO:0072395)2.50744211
136mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.2420131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.53107901
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81425026
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63042852
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.32648608
5EZH2_22144423_ChIP-Seq_EOC_Human3.21208809
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.93341497
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75282015
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56221538
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42409773
10TAF15_26573619_Chip-Seq_HEK293_Human2.39528281
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39239872
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32387718
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30840564
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30800288
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29727696
16GBX2_23144817_ChIP-Seq_PC3_Human2.28308102
17VDR_22108803_ChIP-Seq_LS180_Human2.26914671
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26227769
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.25453341
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24228221
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96200927
22IGF1R_20145208_ChIP-Seq_DFB_Human1.88404435
23FUS_26573619_Chip-Seq_HEK293_Human1.84264355
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83467017
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80292486
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.77943948
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72114232
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70808586
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65601698
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65230776
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61868043
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.61416157
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.60087759
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52071340
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50471024
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50077866
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48319374
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48131534
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47265128
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46563375
41* MYC_18555785_ChIP-Seq_MESCs_Mouse1.46127585
42IRF1_19129219_ChIP-ChIP_H3396_Human1.46027788
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43652118
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41746440
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41254200
46ER_23166858_ChIP-Seq_MCF-7_Human1.39409392
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36040194
48* P300_19829295_ChIP-Seq_ESCs_Human1.34636031
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34471380
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34190874
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.33904920
52ELK1_19687146_ChIP-ChIP_HELA_Human1.33180629
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32290627
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31290536
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30882285
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.29713997
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28997597
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28040753
59DCP1A_22483619_ChIP-Seq_HELA_Human1.27267323
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.27089962
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26717186
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.26526400
63TP53_22573176_ChIP-Seq_HFKS_Human1.25693027
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25066193
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24578726
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22862360
67HTT_18923047_ChIP-ChIP_STHdh_Human1.22798919
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22271351
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19759420
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17997334
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.17148830
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16820407
73GABP_19822575_ChIP-Seq_HepG2_Human1.15257342
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15248793
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14646756
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14603745
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12405761
78ZNF274_21170338_ChIP-Seq_K562_Hela1.12385522
79VDR_23849224_ChIP-Seq_CD4+_Human1.11631940
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10681181
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08771166
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08112456
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06259361
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06259037
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02320046
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02294457
87* TTF2_22483619_ChIP-Seq_HELA_Human1.01130726
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00566903
89CBP_20019798_ChIP-Seq_JUKART_Human1.00566903
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99456565
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99456565
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99419473
93MYC_18940864_ChIP-ChIP_HL60_Human0.98980112
94* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98757489
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97890576
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.97768660
97RNF2_27304074_Chip-Seq_NSC_Mouse0.97041170
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.95444500
99REST_21632747_ChIP-Seq_MESCs_Mouse0.94679066
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94530747
101SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94146407
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94055915
103KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93830379
104SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92182429
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.92154430
106XRN2_22483619_ChIP-Seq_HELA_Human0.91396540
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90888346
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90643100
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.90109216
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90109216
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.89560323
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89446021
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.89323819
114REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88418510
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.88408970
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87782756
117PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87648287
118JUN_21703547_ChIP-Seq_K562_Human0.86647291
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86570543
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86546583
121* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86397571
122SOX2_19829295_ChIP-Seq_ESCs_Human0.85963847
123NANOG_19829295_ChIP-Seq_ESCs_Human0.85963847
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85486007
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85476185
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.84983677
127EWS_26573619_Chip-Seq_HEK293_Human0.84845291
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84246227
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.84076937
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83884020
131* FOXP3_21729870_ChIP-Seq_TREG_Human0.83666897
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.82861929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.15947614
2MP0002837_dystrophic_cardiac_calcinosis3.90294906
3MP0003880_abnormal_central_pattern3.63546761
4MP0006292_abnormal_olfactory_placode3.08965437
5* MP0001529_abnormal_vocalization2.90899859
6MP0006276_abnormal_autonomic_nervous2.70919936
7MP0001905_abnormal_dopamine_level2.59512668
8* MP0006036_abnormal_mitochondrial_physio2.58516958
9MP0003806_abnormal_nucleotide_metabolis2.52414245
10MP0008789_abnormal_olfactory_epithelium2.40531883
11MP0000751_myopathy2.36248283
12MP0003646_muscle_fatigue2.31552063
13MP0004145_abnormal_muscle_electrophysio2.14802287
14MP0004215_abnormal_myocardial_fiber2.13231498
15MP0002736_abnormal_nociception_after2.07131531
16MP0001968_abnormal_touch/_nociception2.03867484
17MP0000749_muscle_degeneration2.02256871
18MP0002272_abnormal_nervous_system1.97599076
19MP0004036_abnormal_muscle_relaxation1.94552166
20MP0005499_abnormal_olfactory_system1.83440815
21MP0005394_taste/olfaction_phenotype1.83440815
22* MP0004142_abnormal_muscle_tone1.83188070
23MP0009745_abnormal_behavioral_response1.79120775
24MP0002735_abnormal_chemical_nociception1.76518354
25MP0004270_analgesia1.75692970
26MP0002638_abnormal_pupillary_reflex1.74595220
27MP0001984_abnormal_olfaction1.69821834
28MP0008877_abnormal_DNA_methylation1.68185180
29MP0003136_yellow_coat_color1.62330286
30MP0003121_genomic_imprinting1.61897675
31* MP0002064_seizures1.61787471
32MP0005253_abnormal_eye_physiology1.60871521
33MP0009046_muscle_twitch1.60067825
34* MP0006035_abnormal_mitochondrial_morpho1.58444823
35MP0008058_abnormal_DNA_repair1.56836676
36MP0003787_abnormal_imprinting1.54002801
37MP0001293_anophthalmia1.53510086
38MP0003137_abnormal_impulse_conducting1.53068533
39MP0002234_abnormal_pharynx_morphology1.50342329
40* MP0002572_abnormal_emotion/affect_behav1.50127966
41MP0004043_abnormal_pH_regulation1.50034650
42MP0003635_abnormal_synaptic_transmissio1.49701332
43MP0003718_maternal_effect1.49566957
44MP0002822_catalepsy1.48936838
45MP0004084_abnormal_cardiac_muscle1.46464486
46MP0009697_abnormal_copulation1.42622594
47* MP0002734_abnormal_mechanical_nocicepti1.40714906
48MP0008995_early_reproductive_senescence1.37832992
49MP0000631_abnormal_neuroendocrine_gland1.36861047
50MP0000372_irregular_coat_pigmentation1.36545410
51MP0002063_abnormal_learning/memory/cond1.35281322
52MP0010030_abnormal_orbit_morphology1.34063651
53MP0002653_abnormal_ependyma_morphology1.33969947
54* MP0001440_abnormal_grooming_behavior1.33738999
55MP0005330_cardiomyopathy1.31928543
56MP0005423_abnormal_somatic_nervous1.31262280
57* MP0001486_abnormal_startle_reflex1.30907748
58MP0000778_abnormal_nervous_system1.30847312
59* MP0005386_behavior/neurological_phenoty1.30729161
60* MP0004924_abnormal_behavior1.30729161
61MP0004484_altered_response_of1.30469950
62* MP0002067_abnormal_sensory_capabilities1.29979806
63MP0003195_calcinosis1.28536683
64MP0004147_increased_porphyrin_level1.27638143
65MP0005620_abnormal_muscle_contractility1.26842186
66MP0002332_abnormal_exercise_endurance1.26324446
67MP0002733_abnormal_thermal_nociception1.23334364
68MP0000049_abnormal_middle_ear1.21091261
69MP0002972_abnormal_cardiac_muscle1.20537060
70* MP0001970_abnormal_pain_threshold1.19493643
71MP0003011_delayed_dark_adaptation1.19195919
72MP0003123_paternal_imprinting1.17825205
73MP0002106_abnormal_muscle_physiology1.17654799
74MP0000920_abnormal_myelination1.17316132
75MP0002184_abnormal_innervation1.15763886
76MP0000566_synostosis1.15391452
77MP0005646_abnormal_pituitary_gland1.15278564
78MP0002102_abnormal_ear_morphology1.13867390
79MP0002233_abnormal_nose_morphology1.13092945
80MP0008875_abnormal_xenobiotic_pharmacok1.12207360
81MP0004742_abnormal_vestibular_system1.11896084
82MP0001188_hyperpigmentation1.10220243
83MP0003567_abnormal_fetal_cardiomyocyte1.09059124
84MP0003890_abnormal_embryonic-extraembry1.08646377
85MP0001485_abnormal_pinna_reflex1.08519188
86MP0005409_darkened_coat_color1.08090514
87MP0002876_abnormal_thyroid_physiology1.05359454
88MP0003122_maternal_imprinting1.04605598
89MP0003937_abnormal_limbs/digits/tail_de1.04074120
90MP0002095_abnormal_skin_pigmentation1.03981941
91MP0001727_abnormal_embryo_implantation1.03245366
92MP0005266_abnormal_metabolism1.02245983
93MP0006072_abnormal_retinal_apoptosis1.01601889
94MP0005369_muscle_phenotype1.00977133
95MP0010386_abnormal_urinary_bladder1.00545934
96MP0005379_endocrine/exocrine_gland_phen1.00135053
97MP0002139_abnormal_hepatobiliary_system0.98806894
98* MP0004085_abnormal_heartbeat0.98308375
99MP0003315_abnormal_perineum_morphology0.97508454
100MP0002160_abnormal_reproductive_system0.97202209
101MP0000747_muscle_weakness0.97000466
102* MP0005551_abnormal_eye_electrophysiolog0.96469333
103MP0005332_abnormal_amino_acid0.96149398
104* MP0005535_abnormal_body_temperature0.95967945
105MP0005367_renal/urinary_system_phenotyp0.95862155
106MP0000516_abnormal_urinary_system0.95862155
107MP0002163_abnormal_gland_morphology0.95455738
108* MP0002557_abnormal_social/conspecific_i0.95361217
109MP0005451_abnormal_body_composition0.95313559
110MP0008872_abnormal_physiological_respon0.93346355
111* MP0005195_abnormal_posterior_eye0.92983515
112MP0005083_abnormal_biliary_tract0.92601085
113MP0002751_abnormal_autonomic_nervous0.92403117
114MP0004885_abnormal_endolymph0.92155407
115* MP0002066_abnormal_motor_capabilities/c0.91518728
116MP0001299_abnormal_eye_distance/0.91460020
117MP0004133_heterotaxia0.90583146
118MP0005391_vision/eye_phenotype0.89236538
119MP0005084_abnormal_gallbladder_morpholo0.88964648
120MP0001986_abnormal_taste_sensitivity0.87983278
121* MP0003186_abnormal_redox_activity0.87441836
122MP0000647_abnormal_sebaceous_gland0.87427158
123MP0002277_abnormal_respiratory_mucosa0.87010877
124MP0005636_abnormal_mineral_homeostasis0.86741533
125MP0002938_white_spotting0.85981542
126MP0001501_abnormal_sleep_pattern0.85951852
127MP0001286_abnormal_eye_development0.85139913
128MP0000750_abnormal_muscle_regeneration0.85017089
129MP0005085_abnormal_gallbladder_physiolo0.83735187
130* MP0002752_abnormal_somatic_nervous0.82724960
131MP0005187_abnormal_penis_morphology0.82365692
132MP0000230_abnormal_systemic_arterial0.82065482
133MP0005645_abnormal_hypothalamus_physiol0.82053879
134MP0003938_abnormal_ear_development0.81557625
135* MP0002229_neurodegeneration0.81460070
136MP0005389_reproductive_system_phenotype0.81241728
137MP0001764_abnormal_homeostasis0.80066510
138MP0008775_abnormal_heart_ventricle0.79835723
139MP0000026_abnormal_inner_ear0.79812704
140MP0001544_abnormal_cardiovascular_syste0.79547180
141MP0001324_abnormal_eye_pigmentation0.78852279
142MP0002210_abnormal_sex_determination0.77719042
143MP0003119_abnormal_digestive_system0.77649946
144MP0003786_premature_aging0.77032396

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)7.49011587
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.88851680
3* Mitochondrial inheritance (HP:0001427)6.46044740
4* Acute encephalopathy (HP:0006846)6.31014431
5* Progressive macrocephaly (HP:0004481)6.29627167
6* Increased CSF lactate (HP:0002490)5.49415379
7* Hepatocellular necrosis (HP:0001404)5.15818808
8Increased hepatocellular lipid droplets (HP:0006565)5.10437448
9Lipid accumulation in hepatocytes (HP:0006561)4.83260720
10* Hepatic necrosis (HP:0002605)4.77014788
11Increased serum pyruvate (HP:0003542)4.72732742
12Abnormality of glycolysis (HP:0004366)4.72732742
13* Cerebral edema (HP:0002181)4.71893048
14Renal Fanconi syndrome (HP:0001994)4.57777527
15Increased intramyocellular lipid droplets (HP:0012240)4.36052781
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.17615143
17* Exercise intolerance (HP:0003546)3.96823172
18Increased muscle lipid content (HP:0009058)3.95294920
19* Respiratory failure (HP:0002878)3.88624478
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.82801398
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.82801398
22* Lactic acidosis (HP:0003128)3.81155407
23* Optic disc pallor (HP:0000543)3.80297224
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.78737058
253-Methylglutaconic aciduria (HP:0003535)3.73931383
26* Leukodystrophy (HP:0002415)3.69676178
27* Increased serum lactate (HP:0002151)3.32437132
28Exertional dyspnea (HP:0002875)3.10833635
29Neuroendocrine neoplasm (HP:0100634)3.10756109
30Abnormality of renal resorption (HP:0011038)3.10048233
31Congenital, generalized hypertrichosis (HP:0004540)3.09226304
32Abnormality of cells of the erythroid lineage (HP:0012130)3.01072383
33Pheochromocytoma (HP:0002666)2.91039240
34Muscle hypertrophy of the lower extremities (HP:0008968)2.89156798
35Respiratory difficulties (HP:0002880)2.77997186
36Abnormality of midbrain morphology (HP:0002418)2.76053869
37Molar tooth sign on MRI (HP:0002419)2.76053869
38Pancreatic fibrosis (HP:0100732)2.68463753
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67493302
40Glycosuria (HP:0003076)2.67195281
41Abnormality of urine glucose concentration (HP:0011016)2.67195281
42True hermaphroditism (HP:0010459)2.63813326
43Colon cancer (HP:0003003)2.61203326
44* X-linked dominant inheritance (HP:0001423)2.60427033
45Pancreatic cysts (HP:0001737)2.60178811
46Abnormal number of erythroid precursors (HP:0012131)2.58716215
47Calf muscle hypertrophy (HP:0008981)2.58619731
48* Lethargy (HP:0001254)2.55604644
49Parakeratosis (HP:0001036)2.54318757
50Hyperglycinemia (HP:0002154)2.45017840
51Macrocytic anemia (HP:0001972)2.40144689
52Septo-optic dysplasia (HP:0100842)2.40090532
53Hyperphosphaturia (HP:0003109)2.39965273
54Nephronophthisis (HP:0000090)2.37191295
55* CNS demyelination (HP:0007305)2.34435845
56Myokymia (HP:0002411)2.29330952
57Reticulocytopenia (HP:0001896)2.26747311
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26323157
59Abnormality of alanine metabolism (HP:0010916)2.26323157
60Hyperalaninemia (HP:0003348)2.26323157
61Methylmalonic acidemia (HP:0002912)2.23419607
62Genital tract atresia (HP:0001827)2.22445577
63Vaginal atresia (HP:0000148)2.21792846
64Methylmalonic aciduria (HP:0012120)2.19969357
65Abnormal pupillary function (HP:0007686)2.18341849
66Abnormality of the labia minora (HP:0012880)2.17055367
67Palpitations (HP:0001962)2.15653061
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08924018
69Dicarboxylic aciduria (HP:0003215)2.08924018
70* Emotional lability (HP:0000712)2.07407447
71Sudden death (HP:0001699)2.07127348
72Sclerocornea (HP:0000647)2.02502641
73Conjunctival hamartoma (HP:0100780)2.01368035
74Exercise-induced myalgia (HP:0003738)2.00961399
75Abnormal urine phosphate concentration (HP:0012599)2.00279069
76Limb dystonia (HP:0002451)1.99851733
77Sensory axonal neuropathy (HP:0003390)1.99712007
78Myoglobinuria (HP:0002913)1.98760919
79Cerebral hemorrhage (HP:0001342)1.97233466
80Generalized aminoaciduria (HP:0002909)1.96856015
81Abnormality of serum amino acid levels (HP:0003112)1.96779770
82Stenosis of the external auditory canal (HP:0000402)1.95860080
83Hypothermia (HP:0002045)1.95370971
84Abnormality of placental membranes (HP:0011409)1.95339600
85Amniotic constriction ring (HP:0009775)1.95339600
86* Vomiting (HP:0002013)1.94326518
87Abnormality of the renal medulla (HP:0100957)1.91909138
88Congenital ichthyosiform erythroderma (HP:0007431)1.91193596
89Rhabdomyolysis (HP:0003201)1.86194984
90Myotonia (HP:0002486)1.83669273
91Intestinal atresia (HP:0011100)1.82351866
92Exercise-induced muscle cramps (HP:0003710)1.81697354
93Muscle stiffness (HP:0003552)1.80901149
94Poor suck (HP:0002033)1.80894038
95Medial flaring of the eyebrow (HP:0010747)1.80851050
96Abnormal hemoglobin (HP:0011902)1.80681421
97Progressive external ophthalmoplegia (HP:0000590)1.80677324
98Optic nerve hypoplasia (HP:0000609)1.80129495
99Poor coordination (HP:0002370)1.77151783
100Nemaline bodies (HP:0003798)1.76565050
101Polyphagia (HP:0002591)1.76425748
102Renal tubular dysfunction (HP:0000124)1.74957669
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74127990
104Rimmed vacuoles (HP:0003805)1.73746191
105Concave nail (HP:0001598)1.73600970
106Gait imbalance (HP:0002141)1.73512043
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72777230
108Muscle fiber inclusion bodies (HP:0100299)1.72647361
109Type I transferrin isoform profile (HP:0003642)1.72449873
110Absent septum pellucidum (HP:0001331)1.71177020
111Type 2 muscle fiber atrophy (HP:0003554)1.70953717
112Microvesicular hepatic steatosis (HP:0001414)1.70831587
113Ragged-red muscle fibers (HP:0003200)1.70800749
114Hyperventilation (HP:0002883)1.70375408
115Pallor (HP:0000980)1.69922029
116Abolished electroretinogram (ERG) (HP:0000550)1.69172373
117Male pseudohermaphroditism (HP:0000037)1.68900797
118Hyperglycinuria (HP:0003108)1.68385546
119Anophthalmia (HP:0000528)1.67801490
120Hypoplastic left heart (HP:0004383)1.67644836
121Abnormality of methionine metabolism (HP:0010901)1.66937290
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.66885218
123Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66841715
124Anencephaly (HP:0002323)1.66635495
125Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65587588
126Abnormality of the anterior horn cell (HP:0006802)1.64418919
127Degeneration of anterior horn cells (HP:0002398)1.64418919
128Congenital primary aphakia (HP:0007707)1.62643473
129* Blindness (HP:0000618)1.60359823
130Abnormality of the calf musculature (HP:0001430)1.60153688
131Congenital stationary night blindness (HP:0007642)1.60004149
132Cholecystitis (HP:0001082)1.59625816
133Abnormal gallbladder physiology (HP:0012438)1.59625816
134Abnormality of serine family amino acid metabolism (HP:0010894)1.57944220
135Abnormality of glycine metabolism (HP:0010895)1.57944220
136Focal motor seizures (HP:0011153)1.57922051
137Abnormality of vitamin B metabolism (HP:0004340)1.57910188
138Renal cortical cysts (HP:0000803)1.57175144
139Pendular nystagmus (HP:0012043)1.56374818
140Nephrogenic diabetes insipidus (HP:0009806)1.56297814
141Metabolic acidosis (HP:0001942)1.54627115
142Abnormality of fatty-acid metabolism (HP:0004359)1.53709794
143Anxiety (HP:0000739)1.53497480
144* Gliosis (HP:0002171)1.52578789
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.51764230
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.51764230
147Progressive inability to walk (HP:0002505)1.50031199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.29750201
2VRK23.14580502
3MAP3K123.08405390
4OBSCN2.87761582
5STK392.75243659
6CASK2.72632714
7NME22.56395838
8STK162.34960639
9MYLK2.29504767
10PBK2.27168766
11OXSR12.23605427
12MAP4K22.23086906
13MST42.12625440
14GRK72.02830368
15WNK41.90332105
16LIMK11.86046373
17BCKDK1.84899765
18ARAF1.83651987
19CDK191.82392895
20MAP2K71.81140753
21ZAK1.80531869
22BCR1.78305940
23NUAK11.73634654
24PHKG11.68813584
25PHKG21.68813584
26PNCK1.67401166
27NEK11.59499153
28MUSK1.58758039
29BMPR1B1.57088842
30TRIM281.55604049
31MAPK131.51532245
32MARK11.50970700
33TNIK1.50735550
34DYRK21.45979941
35PDK31.44739079
36PDK41.44739079
37WNK31.41799870
38CAMK2B1.38688221
39VRK11.37507591
40PLK41.37374385
41PLK31.35812963
42WEE11.33413180
43GRK51.31409494
44CDC71.31273812
45MAP3K41.29264876
46MKNK21.26101593
47CAMK2D1.25260320
48MAPKAPK51.23154758
49TAF11.19827771
50GRK11.19713123
51UHMK11.18944871
52ADRBK21.16943262
53CAMK2A1.11177125
54EPHB21.10140626
55ERBB31.09526414
56INSRR1.08083880
57SRPK11.07336436
58PLK21.05503567
59CAMK2G1.04261003
60EIF2AK11.03846298
61BUB11.03557313
62MAP2K41.03232697
63TLK11.03162467
64PKN10.99769661
65BRAF0.96342847
66EPHA40.95889375
67CSNK1G30.94178121
68BMPR20.90966915
69FRK0.90960942
70PDK20.89925162
71TIE10.89893425
72PIK3CG0.89037659
73PIK3CA0.87701317
74PLK10.85647098
75CSNK1A1L0.83548439
76ADRBK10.82458539
77NTRK30.78427233
78MINK10.78290534
79DAPK30.77827997
80TSSK60.75650902
81ABL20.75456752
82CCNB10.74991871
83ILK0.73079040
84PRKCE0.70864669
85EIF2AK30.69766450
86BRSK20.67593250
87NTRK20.67413586
88ROCK20.66385324
89CSNK1G20.65821777
90CDK140.65384645
91* PRKACA0.65138126
92PINK10.64814175
93AURKB0.62670440
94PAK30.61329159
95CDK180.58190033
96LMTK20.58053132
97CDK150.54278725
98PRKCG0.53558478
99CDK11A0.52671769
100FGR0.52662081
101EIF2AK20.51918648
102MAPK120.51182725
103CSNK1G10.50551329
104MAPK150.50174212
105PTK2B0.50105588
106PIM20.49760300
107MAPK40.48060469
108CDK50.46694281
109CSNK2A20.44534375
110CSNK1E0.44290161
111DYRK30.44234092
112CSNK1A10.44074070
113CHEK20.43880911
114TTK0.43294433
115YES10.43147114
116MAP2K60.42561054
117DYRK1A0.42140008
118CSNK2A10.41694780
119PRKG10.41491500
120STK38L0.40430905
121AURKA0.39186189
122ERBB40.38075848
123DAPK10.35370417
124SGK4940.35185541
125SGK2230.35185541
126PRKACB0.33886875
127MKNK10.32046365
128SIK30.31362472
129TESK10.31271262
130RPS6KA50.30209008

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.16311321
2Parkinsons disease_Homo sapiens_hsa050125.26823028
3Alzheimers disease_Homo sapiens_hsa050104.01029301
4Huntingtons disease_Homo sapiens_hsa050163.65951017
5Ribosome_Homo sapiens_hsa030103.55728462
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.27063495
7Cardiac muscle contraction_Homo sapiens_hsa042602.94489803
8Proteasome_Homo sapiens_hsa030502.85426292
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74730162
10Protein export_Homo sapiens_hsa030602.40941643
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34912281
12Fatty acid elongation_Homo sapiens_hsa000622.28230045
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09890458
14Propanoate metabolism_Homo sapiens_hsa006401.93405790
15RNA polymerase_Homo sapiens_hsa030201.71109892
16Sulfur metabolism_Homo sapiens_hsa009201.67360242
17Pyruvate metabolism_Homo sapiens_hsa006201.67117882
18Mismatch repair_Homo sapiens_hsa034301.61582735
19Collecting duct acid secretion_Homo sapiens_hsa049661.59615344
20Homologous recombination_Homo sapiens_hsa034401.56773594
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56645173
22Butanoate metabolism_Homo sapiens_hsa006501.53235620
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50369887
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35492849
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29761065
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20094388
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18329824
28Carbon metabolism_Homo sapiens_hsa012001.10969639
29Steroid biosynthesis_Homo sapiens_hsa001001.10755522
30DNA replication_Homo sapiens_hsa030301.09359415
31Fanconi anemia pathway_Homo sapiens_hsa034601.08839779
32Vibrio cholerae infection_Homo sapiens_hsa051101.04801579
33Nicotine addiction_Homo sapiens_hsa050331.04737962
34Tyrosine metabolism_Homo sapiens_hsa003501.03547361
35Fatty acid degradation_Homo sapiens_hsa000710.95871990
36One carbon pool by folate_Homo sapiens_hsa006700.95366414
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94792907
38Base excision repair_Homo sapiens_hsa034100.92390418
39* Metabolic pathways_Homo sapiens_hsa011000.92158006
40Peroxisome_Homo sapiens_hsa041460.91334087
41RNA transport_Homo sapiens_hsa030130.87431893
42Histidine metabolism_Homo sapiens_hsa003400.87007136
43Phenylalanine metabolism_Homo sapiens_hsa003600.86979362
44Fatty acid metabolism_Homo sapiens_hsa012120.86332939
45Glutathione metabolism_Homo sapiens_hsa004800.82200662
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81167125
47Pyrimidine metabolism_Homo sapiens_hsa002400.79660532
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79541758
49Non-homologous end-joining_Homo sapiens_hsa034500.78167135
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.77869081
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75096091
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74340917
53Nitrogen metabolism_Homo sapiens_hsa009100.72743068
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71362855
55Serotonergic synapse_Homo sapiens_hsa047260.70188706
56Arginine and proline metabolism_Homo sapiens_hsa003300.69058364
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68498923
58Synaptic vesicle cycle_Homo sapiens_hsa047210.68178977
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68046130
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67544662
61Asthma_Homo sapiens_hsa053100.65523856
62Ether lipid metabolism_Homo sapiens_hsa005650.64964611
63Chemical carcinogenesis_Homo sapiens_hsa052040.64873773
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63942399
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62449775
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61188844
67GABAergic synapse_Homo sapiens_hsa047270.59126286
68Linoleic acid metabolism_Homo sapiens_hsa005910.57956479
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.57954637
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55770577
71Purine metabolism_Homo sapiens_hsa002300.52987019
72Tryptophan metabolism_Homo sapiens_hsa003800.52859826
73Arachidonic acid metabolism_Homo sapiens_hsa005900.50553361
74beta-Alanine metabolism_Homo sapiens_hsa004100.50269096
75Taste transduction_Homo sapiens_hsa047420.48078875
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.47631764
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47548657
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47446817
79Caffeine metabolism_Homo sapiens_hsa002320.44355350
80Folate biosynthesis_Homo sapiens_hsa007900.43070239
81Selenocompound metabolism_Homo sapiens_hsa004500.42387554
82Basal cell carcinoma_Homo sapiens_hsa052170.41815938
83Phototransduction_Homo sapiens_hsa047440.41489598
84Morphine addiction_Homo sapiens_hsa050320.39201442
85Rheumatoid arthritis_Homo sapiens_hsa053230.38265141
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37941414
87Biosynthesis of amino acids_Homo sapiens_hsa012300.37390020
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37035815
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.36591783
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36442174
91Glutamatergic synapse_Homo sapiens_hsa047240.35199159
92Dopaminergic synapse_Homo sapiens_hsa047280.33484330
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32889686
94Spliceosome_Homo sapiens_hsa030400.31864502
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31831521
96Amphetamine addiction_Homo sapiens_hsa050310.31494511
97Hedgehog signaling pathway_Homo sapiens_hsa043400.31116700
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.30225053
99Circadian entrainment_Homo sapiens_hsa047130.30078356
100Calcium signaling pathway_Homo sapiens_hsa040200.28851717
101Oocyte meiosis_Homo sapiens_hsa041140.28454565
102Retinol metabolism_Homo sapiens_hsa008300.28189621
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28092941
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26173139
105Cell cycle_Homo sapiens_hsa041100.25747250
106Dilated cardiomyopathy_Homo sapiens_hsa054140.25503321
107PPAR signaling pathway_Homo sapiens_hsa033200.24906772
108Phagosome_Homo sapiens_hsa041450.24570268
109Systemic lupus erythematosus_Homo sapiens_hsa053220.23350667
110Sulfur relay system_Homo sapiens_hsa041220.22502263
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21809134
112Basal transcription factors_Homo sapiens_hsa030220.21681463
113Nucleotide excision repair_Homo sapiens_hsa034200.20370911
114Long-term depression_Homo sapiens_hsa047300.19744384
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19575404
116Olfactory transduction_Homo sapiens_hsa047400.18909781
117Fat digestion and absorption_Homo sapiens_hsa049750.17826109
118Renin secretion_Homo sapiens_hsa049240.17668956
119Regulation of autophagy_Homo sapiens_hsa041400.16782654
120Cocaine addiction_Homo sapiens_hsa050300.16314390
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15719471
122RNA degradation_Homo sapiens_hsa030180.14302137
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13543194
124Starch and sucrose metabolism_Homo sapiens_hsa005000.12333766
125Cholinergic synapse_Homo sapiens_hsa047250.11246671
126Pentose phosphate pathway_Homo sapiens_hsa000300.10783852

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »