NDUFS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-histidine modification (GO:0018202)7.60003900
2tricarboxylic acid cycle (GO:0006099)6.61905755
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.07605255
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.58104946
5ATP synthesis coupled proton transport (GO:0015986)5.58104946
6oxidative phosphorylation (GO:0006119)5.54258443
7NADH metabolic process (GO:0006734)5.51030424
8* respiratory electron transport chain (GO:0022904)5.37856232
9* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28273713
10* electron transport chain (GO:0022900)5.24029087
11lysine metabolic process (GO:0006553)5.18239785
12lysine catabolic process (GO:0006554)5.18239785
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.86616659
14succinate metabolic process (GO:0006105)4.86215457
152-oxoglutarate metabolic process (GO:0006103)4.80164106
16fatty acid beta-oxidation (GO:0006635)4.66810621
17branched-chain amino acid catabolic process (GO:0009083)4.65050486
18carnitine shuttle (GO:0006853)4.60045613
19regulation of acyl-CoA biosynthetic process (GO:0050812)4.55092003
20kinetochore organization (GO:0051383)4.49395754
21aspartate family amino acid catabolic process (GO:0009068)4.48978975
22oxaloacetate metabolic process (GO:0006107)4.43588361
23fatty acid transmembrane transport (GO:1902001)4.41151553
24L-phenylalanine metabolic process (GO:0006558)4.34604980
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34604980
26regulation of coenzyme metabolic process (GO:0051196)4.30308735
27regulation of cofactor metabolic process (GO:0051193)4.30308735
28cellular ketone body metabolic process (GO:0046950)4.25201194
29glyoxylate metabolic process (GO:0046487)4.22272266
30branched-chain amino acid metabolic process (GO:0009081)4.19413496
31establishment of integrated proviral latency (GO:0075713)4.18086563
32tricarboxylic acid metabolic process (GO:0072350)4.16455501
33fatty acid catabolic process (GO:0009062)4.12897730
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.08732204
35L-phenylalanine catabolic process (GO:0006559)4.08732204
36fatty acid oxidation (GO:0019395)4.08442011
37acetyl-CoA metabolic process (GO:0006084)4.05462502
38short-chain fatty acid metabolic process (GO:0046459)4.05257180
39mitochondrial respiratory chain complex I assembly (GO:0032981)4.03826433
40NADH dehydrogenase complex assembly (GO:0010257)4.03826433
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03826433
42regulation of sequestering of triglyceride (GO:0010889)4.03441477
43lipid oxidation (GO:0034440)4.01638644
44valine metabolic process (GO:0006573)4.01623736
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.99638527
46ribosomal small subunit biogenesis (GO:0042274)3.90368616
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89436545
48sarcomere organization (GO:0045214)3.88327193
49quinone biosynthetic process (GO:1901663)3.85569156
50ubiquinone biosynthetic process (GO:0006744)3.85569156
51maturation of SSU-rRNA (GO:0030490)3.82563930
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.81281247
53ATP biosynthetic process (GO:0006754)3.77245057
54DNA double-strand break processing (GO:0000729)3.75583778
55monocarboxylic acid catabolic process (GO:0072329)3.74131517
56chaperone-mediated protein transport (GO:0072321)3.71595351
57ketone body metabolic process (GO:1902224)3.69165613
58regulation of fatty acid oxidation (GO:0046320)3.68360916
59amino-acid betaine metabolic process (GO:0006577)3.65589040
60kinetochore assembly (GO:0051382)3.64956058
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59618226
62aerobic respiration (GO:0009060)3.57089842
63protein targeting to mitochondrion (GO:0006626)3.54760638
64carnitine transmembrane transport (GO:1902603)3.52378955
65carnitine metabolic process (GO:0009437)3.51877519
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.51756956
67establishment of viral latency (GO:0019043)3.51739678
68respiratory chain complex IV assembly (GO:0008535)3.51456521
69positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49253395
70amino-acid betaine transport (GO:0015838)3.48487027
71carnitine transport (GO:0015879)3.48487027
72regulation of sulfur metabolic process (GO:0042762)3.48370081
73actin-myosin filament sliding (GO:0033275)3.47153969
74muscle filament sliding (GO:0030049)3.47153969
75aromatic amino acid family catabolic process (GO:0009074)3.46644617
76kynurenine metabolic process (GO:0070189)3.46337564
77cysteine metabolic process (GO:0006534)3.43141497
78meiotic chromosome segregation (GO:0045132)3.42148100
79regulation of oxidative phosphorylation (GO:0002082)3.41876427
80ribosomal small subunit assembly (GO:0000028)3.40342506
81viral transcription (GO:0019083)3.39656045
82biotin metabolic process (GO:0006768)3.39196502
83base-excision repair, AP site formation (GO:0006285)3.38412666
84pyrimidine nucleotide catabolic process (GO:0006244)3.35613455
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.32913386
86termination of RNA polymerase III transcription (GO:0006386)3.32913386
87establishment of protein localization to mitochondrion (GO:0072655)3.31594508
88cytochrome complex assembly (GO:0017004)3.31131321
89inner mitochondrial membrane organization (GO:0007007)3.30339646
90metallo-sulfur cluster assembly (GO:0031163)3.30249716
91iron-sulfur cluster assembly (GO:0016226)3.30249716
92regulation of triglyceride catabolic process (GO:0010896)3.29055717
93RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.28761526
94organic acid catabolic process (GO:0016054)3.28026147
95carboxylic acid catabolic process (GO:0046395)3.28026147
96regulation of mitochondrial translation (GO:0070129)3.27677391
97ubiquinone metabolic process (GO:0006743)3.27025565
98telomere maintenance via semi-conservative replication (GO:0032201)3.26644150
99alpha-amino acid catabolic process (GO:1901606)3.25972921
100DNA strand elongation involved in DNA replication (GO:0006271)3.24109549
101sulfur amino acid catabolic process (GO:0000098)3.23636337
102regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.22807482
103NAD metabolic process (GO:0019674)3.20990468
104cellular amino acid catabolic process (GO:0009063)3.20034903
105positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.19990464
106translational termination (GO:0006415)3.19362565
107proteasome assembly (GO:0043248)3.19317901
108cardiac muscle contraction (GO:0060048)3.19215170
109cardiac myofibril assembly (GO:0055003)3.18897378
110positive regulation of mitochondrial fission (GO:0090141)3.18582702
111protein localization to mitochondrion (GO:0070585)3.18175351
112purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17276223
113alpha-linolenic acid metabolic process (GO:0036109)3.16329451
114positive regulation of fatty acid oxidation (GO:0046321)3.15139410
115GTP biosynthetic process (GO:0006183)3.14366404
116positive regulation of myoblast differentiation (GO:0045663)3.14261272
117purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13901559
118gluconeogenesis (GO:0006094)3.13251208
119serine family amino acid catabolic process (GO:0009071)3.12906221
120cellular component biogenesis (GO:0044085)3.11470983
121ethanol oxidation (GO:0006069)3.09953505
122positive regulation of vasculogenesis (GO:2001214)3.09845779
123DNA strand elongation (GO:0022616)3.08896554
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.06892566
125indole-containing compound catabolic process (GO:0042436)3.06567276
126indolalkylamine catabolic process (GO:0046218)3.06567276
127tryptophan catabolic process (GO:0006569)3.06567276
128DNA catabolic process, exonucleolytic (GO:0000738)3.06010980
129regulation of skeletal muscle contraction (GO:0014819)3.05645203
130ribonucleoprotein complex biogenesis (GO:0022613)3.04303752
131protein complex biogenesis (GO:0070271)3.03449249
132protein K6-linked ubiquitination (GO:0085020)3.02791254
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02198328
134regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01931447
135translational elongation (GO:0006414)3.00435981
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99464835
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99417260
138pseudouridine synthesis (GO:0001522)2.98626065
139cellular respiration (GO:0045333)2.98396530
140response to mercury ion (GO:0046689)2.98341182
141hexose biosynthetic process (GO:0019319)2.98127680
142negative regulation of mRNA processing (GO:0050686)2.97179162
143negative regulation of Notch signaling pathway (GO:0045746)2.96509188
144ribosome biogenesis (GO:0042254)2.96477839
145negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95443944
146transcription from mitochondrial promoter (GO:0006390)2.94692214
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94556207
148chromatin remodeling at centromere (GO:0031055)2.94165610
149mitotic chromosome condensation (GO:0007076)2.94091689
150quaternary ammonium group transport (GO:0015697)2.93738020
151dicarboxylic acid metabolic process (GO:0043648)2.93386256
152CTP biosynthetic process (GO:0006241)2.93240855
153CTP metabolic process (GO:0046036)2.93240855
154base-excision repair (GO:0006284)2.93020991
155mitochondrial respiratory chain complex assembly (GO:0033108)2.92502959
156myofibril assembly (GO:0030239)2.91792320
157UTP biosynthetic process (GO:0006228)2.91744436
158DNA ligation (GO:0006266)2.90306682
159coenzyme catabolic process (GO:0009109)2.89756948
160cotranslational protein targeting to membrane (GO:0006613)2.89677856
161bile acid biosynthetic process (GO:0006699)2.88966586
162translation (GO:0006412)2.88918508
163deoxyribonucleotide catabolic process (GO:0009264)2.88801260
164dicarboxylic acid catabolic process (GO:0043649)2.88658264
165tryptophan metabolic process (GO:0006568)2.88575355
166regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88357856
167positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88153940
168protein targeting to ER (GO:0045047)2.85960007
169anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85743167
170mitochondrial RNA metabolic process (GO:0000959)2.85440354
171tRNA processing (GO:0008033)2.85139965
172spliceosomal snRNP assembly (GO:0000387)2.83789643
173DNA unwinding involved in DNA replication (GO:0006268)2.82964624
174ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81848858
175protein hydroxylation (GO:0018126)2.81354732
176UTP metabolic process (GO:0046051)2.80305951
177protein localization to endoplasmic reticulum (GO:0070972)2.78865312
178pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78076408
179mitotic recombination (GO:0006312)2.77761984
180hydrogen ion transmembrane transport (GO:1902600)2.77384378
181deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75589832
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75222595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.02465944
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.12508637
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.54193269
4E2F7_22180533_ChIP-Seq_HELA_Human4.21991902
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.19791214
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19482768
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.13906113
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32949023
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.27068873
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.18531826
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12045012
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81149202
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74755644
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.72050919
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71571050
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61067334
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.60711905
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33912724
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29941638
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16004381
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14747206
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.14017128
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13889878
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13697745
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.11869126
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03635179
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02645803
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02089268
29ZNF263_19887448_ChIP-Seq_K562_Human2.01764936
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97546800
31* TTF2_22483619_ChIP-Seq_HELA_Human1.91860705
32* GABP_17652178_ChIP-ChIP_JURKAT_Human1.91854881
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83268384
34* MYC_18555785_ChIP-Seq_MESCs_Mouse1.81823064
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.79291395
36BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.78644924
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71285290
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.69339345
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65423069
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64627537
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.63578284
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59793219
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56598636
44ELK1_19687146_ChIP-ChIP_HELA_Human1.51115172
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50408261
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50164371
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49476715
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48915646
49KDM5A_27292631_Chip-Seq_BREAST_Human1.46035641
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45284716
51CLOCK_20551151_ChIP-Seq_293T_Human1.42146089
52MYC_18940864_ChIP-ChIP_HL60_Human1.41758893
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.40951399
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40493698
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38762493
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36857351
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36499719
58* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36496503
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36443118
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.33897517
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33555725
62AR_21909140_ChIP-Seq_LNCAP_Human1.32647175
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31795717
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31564628
65CIITA_25753668_ChIP-Seq_RAJI_Human1.29385493
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28837340
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27502274
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24746135
69GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19989657
70GABP_19822575_ChIP-Seq_HepG2_Human1.18578282
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18561873
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18100131
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17960535
74* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16697284
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.16204809
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.14813535
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.14813535
78* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13895142
79GATA1_22025678_ChIP-Seq_K562_Human1.13658588
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12095455
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11976825
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09147084
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07608263
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07160314
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06252995
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05472905
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.04111084
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03436927
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02366401
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02191118
91* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99464737
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98918876
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98186362
94* XRN2_22483619_ChIP-Seq_HELA_Human0.96518871
95VDR_23849224_ChIP-Seq_CD4+_Human0.95065664
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95040396
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94944403
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93004203
99BCL6_27268052_Chip-Seq_Bcells_Human0.92294650
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92177180
101* FOXP3_21729870_ChIP-Seq_TREG_Human0.92086753
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91331844
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91292354
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91250018
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90900697
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88077451
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88053276
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87733716
109TAF2_19829295_ChIP-Seq_ESCs_Human0.87558893
110P68_20966046_ChIP-Seq_HELA_Human0.87075117
111IRF1_19129219_ChIP-ChIP_H3396_Human0.85539824
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85027050
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84775097
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83957107
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82981788
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82100174
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.81704495
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81226772
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79608966
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79441408
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79155878
122BCOR_27268052_Chip-Seq_Bcells_Human0.78285390
123ERG_20517297_ChIP-Seq_VCAP_Human0.77878847
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77108592
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76924186
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76551612
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.75828721
128ERA_21632823_ChIP-Seq_H3396_Human0.75416704
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.75363410
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74834247
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74607571
132LXR_22292898_ChIP-Seq_THP-1_Human0.74036213
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.73979164
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72458056
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.71612580
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71151791
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70599480
138AR_20517297_ChIP-Seq_VCAP_Human0.70597069
139PHF8_20622854_ChIP-Seq_HELA_Human0.70551679
140E2F1_20622854_ChIP-Seq_HELA_Human0.68969159
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68691714
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68593561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.10318840
2MP0003646_muscle_fatigue4.66752299
3MP0002139_abnormal_hepatobiliary_system4.06223271
4MP0005360_urolithiasis4.02586515
5MP0005085_abnormal_gallbladder_physiolo3.56863468
6MP0003693_abnormal_embryo_hatching3.49414571
7MP0010094_abnormal_chromosome_stability3.46518149
8MP0008058_abnormal_DNA_repair3.39515002
9MP0000751_myopathy3.36184662
10MP0005365_abnormal_bile_salt3.28648019
11MP0003806_abnormal_nucleotide_metabolis3.28367384
12MP0004084_abnormal_cardiac_muscle3.27416386
13MP0006036_abnormal_mitochondrial_physio3.26944503
14MP0004215_abnormal_myocardial_fiber3.26371603
15MP0000749_muscle_degeneration2.96201885
16MP0005330_cardiomyopathy2.92280416
17MP0004036_abnormal_muscle_relaxation2.87884101
18MP0008961_abnormal_basal_metabolism2.79394291
19MP0004130_abnormal_muscle_cell2.69344500
20MP0003111_abnormal_nucleus_morphology2.56560522
21MP0008875_abnormal_xenobiotic_pharmacok2.53464970
22MP0004957_abnormal_blastocyst_morpholog2.46206445
23MP0005332_abnormal_amino_acid2.40690319
24MP0003077_abnormal_cell_cycle2.35680845
25MP0006292_abnormal_olfactory_placode2.30459849
26MP0003195_calcinosis2.24332708
27MP0010329_abnormal_lipoprotein_level2.18940151
28MP0002653_abnormal_ependyma_morphology2.12100612
29MP0005670_abnormal_white_adipose2.09463965
30MP0009379_abnormal_foot_pigmentation2.09336690
31MP0006035_abnormal_mitochondrial_morpho2.09166995
32MP0004087_abnormal_muscle_fiber1.98171317
33MP0002972_abnormal_cardiac_muscle1.97169552
34MP0003718_maternal_effect1.96795426
35MP0008932_abnormal_embryonic_tissue1.95056819
36MP0005620_abnormal_muscle_contractility1.95043805
37MP0002269_muscular_atrophy1.94988017
38MP0004145_abnormal_muscle_electrophysio1.92303427
39MP0008877_abnormal_DNA_methylation1.90839079
40MP0009840_abnormal_foam_cell1.90436512
41MP0003137_abnormal_impulse_conducting1.89996161
42MP0008775_abnormal_heart_ventricle1.86672209
43MP0000750_abnormal_muscle_regeneration1.80114609
44MP0004043_abnormal_pH_regulation1.78413163
45MP0005083_abnormal_biliary_tract1.76671791
46MP0001544_abnormal_cardiovascular_syste1.76168881
47MP0005385_cardiovascular_system_phenoty1.76168881
48MP0008789_abnormal_olfactory_epithelium1.74733487
49MP0003786_premature_aging1.73981644
50MP0003221_abnormal_cardiomyocyte_apopto1.72129475
51MP0002106_abnormal_muscle_physiology1.70566363
52MP0003186_abnormal_redox_activity1.66358007
53MP0005319_abnormal_enzyme/_coenzyme1.64640462
54MP0005666_abnormal_adipose_tissue1.64451766
55MP0001346_abnormal_lacrimal_gland1.62771675
56MP0000747_muscle_weakness1.61051731
57MP0003252_abnormal_bile_duct1.57732644
58MP0002118_abnormal_lipid_homeostasis1.55496571
59MP0005584_abnormal_enzyme/coenzyme_acti1.53556388
60MP0004484_altered_response_of1.53456246
61MP0003123_paternal_imprinting1.51771853
62MP0002332_abnormal_exercise_endurance1.51392425
63MP0006138_congestive_heart_failure1.49610475
64MP0006072_abnormal_retinal_apoptosis1.44803371
65MP0010630_abnormal_cardiac_muscle1.39318126
66MP0001666_abnormal_nutrient_absorption1.36930591
67MP0001764_abnormal_homeostasis1.36739924
68MP0000759_abnormal_skeletal_muscle1.36340146
69MP0005266_abnormal_metabolism1.35391841
70MP0009643_abnormal_urine_homeostasis1.32321148
71MP0005535_abnormal_body_temperature1.31650845
72MP0005369_muscle_phenotype1.30841787
73MP0003191_abnormal_cellular_cholesterol1.29259131
74MP0004147_increased_porphyrin_level1.29258649
75MP0008007_abnormal_cellular_replicative1.27644248
76MP0000372_irregular_coat_pigmentation1.25049330
77MP0004233_abnormal_muscle_weight1.24789896
78MP0008872_abnormal_physiological_respon1.23929197
79MP0002971_abnormal_brown_adipose1.23215125
80MP0004085_abnormal_heartbeat1.23136993
81MP0000609_abnormal_liver_physiology1.22999951
82MP0004019_abnormal_vitamin_homeostasis1.22314372
83MP0005499_abnormal_olfactory_system1.21683342
84MP0005394_taste/olfaction_phenotype1.21683342
85MP0002078_abnormal_glucose_homeostasis1.17637875
86MP0008057_abnormal_DNA_replication1.08069228
87MP0009697_abnormal_copulation1.07981083
88MP0000230_abnormal_systemic_arterial1.07250706
89MP0005636_abnormal_mineral_homeostasis1.06144012
90MP0009672_abnormal_birth_weight1.06121336
91MP0002127_abnormal_cardiovascular_syste1.04518911
92MP0002210_abnormal_sex_determination1.03754123
93MP0000013_abnormal_adipose_tissue1.03292822
94MP0005451_abnormal_body_composition1.02686397
95MP0003656_abnormal_erythrocyte_physiolo1.00331422
96MP0001727_abnormal_embryo_implantation0.96845177
97MP0001661_extended_life_span0.95806060
98MP0001929_abnormal_gametogenesis0.95062207
99MP0005165_increased_susceptibility_to0.94647507
100MP0000313_abnormal_cell_death0.94156120
101MP0003787_abnormal_imprinting0.93870659
102MP0002160_abnormal_reproductive_system0.91764252
103MP0001145_abnormal_male_reproductive0.91684522
104MP0002822_catalepsy0.90739643
105MP0005375_adipose_tissue_phenotype0.88663753
106MP0001905_abnormal_dopamine_level0.87903706
107MP0005376_homeostasis/metabolism_phenot0.87160612
108MP0000653_abnormal_sex_gland0.87134645
109MP0010030_abnormal_orbit_morphology0.85814381
110MP0004185_abnormal_adipocyte_glucose0.85341487
111MP0002090_abnormal_vision0.85244097
112MP0001756_abnormal_urination0.84832349
113MP0003011_delayed_dark_adaptation0.82079558
114MP0002909_abnormal_adrenal_gland0.79988241
115MP0005551_abnormal_eye_electrophysiolog0.79644937
116MP0005334_abnormal_fat_pad0.79412157
117MP0008995_early_reproductive_senescence0.79347470
118MP0005084_abnormal_gallbladder_morpholo0.78778737
119MP0002272_abnormal_nervous_system0.77567823
120MP0003698_abnormal_male_reproductive0.76525997
121MP0001697_abnormal_embryo_size0.76510531
122MP0000350_abnormal_cell_proliferation0.76451524
123MP0010307_abnormal_tumor_latency0.76039874
124MP0002736_abnormal_nociception_after0.75524648
125MP0001730_embryonic_growth_arrest0.74145826
126MP0001968_abnormal_touch/_nociception0.74011057
127MP0001986_abnormal_taste_sensitivity0.72933110
128MP0003828_pulmonary_edema0.71221955
129MP0000343_altered_response_to0.71008334
130MP0009642_abnormal_blood_homeostasis0.70352427
131MP0003567_abnormal_fetal_cardiomyocyte0.69915414
132MP0005423_abnormal_somatic_nervous0.69494468
133MP0000598_abnormal_liver_morphology0.65072990
134MP0001853_heart_inflammation0.64680161
135MP0005646_abnormal_pituitary_gland0.63831754
136MP0001765_abnormal_ion_homeostasis0.63757848
137MP0002876_abnormal_thyroid_physiology0.63680622
138MP0005448_abnormal_energy_balance0.62631031
139MP0002080_prenatal_lethality0.62340764
140MP0005253_abnormal_eye_physiology0.62064891
141MP0003953_abnormal_hormone_level0.61439689
142MP0001502_abnormal_circadian_rhythm0.61403511
143MP0000049_abnormal_middle_ear0.59251635
144MP0009046_muscle_twitch0.59144842
145MP0003880_abnormal_central_pattern0.58821872
146MP0000358_abnormal_cell_content/0.57695857
147MP0003315_abnormal_perineum_morphology0.57644669
148MP0002234_abnormal_pharynx_morphology0.57245394
149MP0002970_abnormal_white_adipose0.56808051
150MP0002161_abnormal_fertility/fecundity0.56329041
151MP0003121_genomic_imprinting0.54012387
152MP0003329_amyloid_beta_deposits0.53702899
153MP0002138_abnormal_hepatobiliary_system0.52380029
154MP0005452_abnormal_adipose_tissue0.51651825
155MP0005595_abnormal_vascular_smooth0.51513393
156MP0000266_abnormal_heart_morphology0.47568668
157MP0009115_abnormal_fat_cell0.45603385
158MP0010368_abnormal_lymphatic_system0.44147135
159MP0001529_abnormal_vocalization0.43270235

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.74963106
2* Hepatic necrosis (HP:0002605)4.66591777
3* Abnormal mitochondria in muscle tissue (HP:0008316)4.43397376
4* Acute necrotizing encephalopathy (HP:0006965)4.38955492
5Hypoglycemic coma (HP:0001325)4.38939847
6* Acute encephalopathy (HP:0006846)4.30968271
7Exercise-induced myalgia (HP:0003738)4.20022559
8Abnormality of fatty-acid metabolism (HP:0004359)4.14561851
9* Cerebral edema (HP:0002181)4.10298832
10Ketoacidosis (HP:0001993)4.06871066
11Ketosis (HP:0001946)4.02597371
12Sudden death (HP:0001699)4.01501641
13* Hepatocellular necrosis (HP:0001404)3.99542742
14Dicarboxylic aciduria (HP:0003215)3.93090328
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.93090328
16* Mitochondrial inheritance (HP:0001427)3.88138464
17Hyperglycinuria (HP:0003108)3.83760531
18Rhabdomyolysis (HP:0003201)3.81411521
19Hyperammonemia (HP:0001987)3.76323785
20* Increased CSF lactate (HP:0002490)3.73741803
21Exercise-induced muscle cramps (HP:0003710)3.69176516
22Increased muscle lipid content (HP:0009058)3.64567727
23* Lactic acidosis (HP:0003128)3.62157046
24Palpitations (HP:0001962)3.58025177
25* Progressive macrocephaly (HP:0004481)3.57537500
26Generalized aminoaciduria (HP:0002909)3.54569546
27Abnormality of glycine metabolism (HP:0010895)3.41262494
28Abnormality of serine family amino acid metabolism (HP:0010894)3.41262494
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35844864
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35844864
31Increased intramyocellular lipid droplets (HP:0012240)3.27822393
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25994188
33Calf muscle hypertrophy (HP:0008981)3.25991811
34* Lethargy (HP:0001254)3.21534147
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20184924
36Abnormality of alanine metabolism (HP:0010916)3.20184924
37Hyperalaninemia (HP:0003348)3.20184924
38Ventricular tachycardia (HP:0004756)3.19454978
39Hyperglycinemia (HP:0002154)3.19396074
40Abnormality of glycolysis (HP:0004366)3.18360562
41Increased serum pyruvate (HP:0003542)3.18360562
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14910124
43Abnormal number of erythroid precursors (HP:0012131)3.05641400
44Dyschromatopsia (HP:0007641)3.04586365
45Muscle hypertrophy of the lower extremities (HP:0008968)3.03873788
46Abnormality of cells of the erythroid lineage (HP:0012130)3.02153301
47Metabolic acidosis (HP:0001942)3.02105650
48Ragged-red muscle fibers (HP:0003200)2.99568623
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98672926
50Muscle fiber inclusion bodies (HP:0100299)2.96261284
51Lipid accumulation in hepatocytes (HP:0006561)2.94868171
52Renal Fanconi syndrome (HP:0001994)2.90704314
53Nemaline bodies (HP:0003798)2.87543578
54* Respiratory failure (HP:0002878)2.84886699
55* Increased serum lactate (HP:0002151)2.84530479
56* Exercise intolerance (HP:0003546)2.84116000
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.80892678
58* Emotional lability (HP:0000712)2.80679296
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77195518
60Reticulocytopenia (HP:0001896)2.77180722
61Nausea (HP:0002018)2.77151824
62Abnormality of serum amino acid levels (HP:0003112)2.72521257
63Proximal tubulopathy (HP:0000114)2.71805024
64Gout (HP:0001997)2.71073222
65Lipoatrophy (HP:0100578)2.68627005
66Xanthomatosis (HP:0000991)2.68015430
67* Vomiting (HP:0002013)2.67475438
68Asymmetric septal hypertrophy (HP:0001670)2.66138350
69Atrial fibrillation (HP:0005110)2.65777403
70Cerebral hypomyelination (HP:0006808)2.65441395
71Microvesicular hepatic steatosis (HP:0001414)2.63365933
72Muscle fiber splitting (HP:0003555)2.61372383
73Hyperlipoproteinemia (HP:0010980)2.55663588
74Conjunctival hamartoma (HP:0100780)2.53351362
75Abnormality of the anterior horn cell (HP:0006802)2.51530616
76Degeneration of anterior horn cells (HP:0002398)2.51530616
77Methylmalonic aciduria (HP:0012120)2.51144528
78Pheochromocytoma (HP:0002666)2.50124188
79Abnormality of the calf musculature (HP:0001430)2.49700306
80Dilated cardiomyopathy (HP:0001644)2.49414897
81Glycosuria (HP:0003076)2.49351230
82Abnormality of urine glucose concentration (HP:0011016)2.49351230
83Supraventricular tachycardia (HP:0004755)2.47760777
84Myopathic facies (HP:0002058)2.47432583
85Primary atrial arrhythmia (HP:0001692)2.46468782
86Increased hepatocellular lipid droplets (HP:0006565)2.45920528
87Microretrognathia (HP:0000308)2.44862452
88Bundle branch block (HP:0011710)2.44191188
89Hypoalphalipoproteinemia (HP:0003233)2.41774510
90Neuroendocrine neoplasm (HP:0100634)2.41746712
91Atrioventricular block (HP:0001678)2.41727686
92Syncope (HP:0001279)2.41052831
93Supraventricular arrhythmia (HP:0005115)2.39922552
94Hypobetalipoproteinemia (HP:0003563)2.38091981
95Intrahepatic cholestasis (HP:0001406)2.34298039
96Muscle stiffness (HP:0003552)2.33774177
97Colon cancer (HP:0003003)2.33760664
98* CNS demyelination (HP:0007305)2.33274613
99Hypolipoproteinemia (HP:0010981)2.32528115
100Heart block (HP:0012722)2.32465349
101Right ventricular cardiomyopathy (HP:0011663)2.30369863
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29030137
103Progressive microcephaly (HP:0000253)2.24425732
104Late onset (HP:0003584)2.23760217
105Multiple enchondromatosis (HP:0005701)2.23654609
1063-Methylglutaconic aciduria (HP:0003535)2.23550586
107Hyperinsulinemic hypoglycemia (HP:0000825)2.22678564
108EMG: myopathic abnormalities (HP:0003458)2.22576574
109Respiratory difficulties (HP:0002880)2.18635834
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17887089
111Cholelithiasis (HP:0001081)2.17176847
112Aplasia/Hypoplasia of the uvula (HP:0010293)2.15710122
113CNS hypomyelination (HP:0003429)2.13727217
114* Leukodystrophy (HP:0002415)2.11699697
115Abnormal atrioventricular conduction (HP:0005150)2.11072442
116Ventricular arrhythmia (HP:0004308)2.10709648
117Neoplasm of the adrenal gland (HP:0100631)2.10101999
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10029792
119Abnormal biliary tract physiology (HP:0012439)2.10004098
120Bile duct proliferation (HP:0001408)2.10004098
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09888206
122Progressive muscle weakness (HP:0003323)2.08931038
123Hyporeflexia of lower limbs (HP:0002600)2.07416437
124Delayed CNS myelination (HP:0002188)2.06207596
125Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06182771
126Increased purine levels (HP:0004368)2.05485569
127Hyperuricemia (HP:0002149)2.05485569
128Chromsome breakage (HP:0040012)2.05304241
129* Optic disc pallor (HP:0000543)2.05240411
130Absent thumb (HP:0009777)2.02480135
131Abnormal rod and cone electroretinograms (HP:0008323)2.01150466
132Abnormality of the ileum (HP:0001549)1.99713159
133Molar tooth sign on MRI (HP:0002419)1.93985997
134Abnormality of midbrain morphology (HP:0002418)1.93985997
135Macrocytic anemia (HP:0001972)1.93824534
136Meckel diverticulum (HP:0002245)1.92792344
137Progressive external ophthalmoplegia (HP:0000590)1.92416964
138Exertional dyspnea (HP:0002875)1.92076265
139Type I transferrin isoform profile (HP:0003642)1.91278058
140* Gliosis (HP:0002171)1.89295438
141Testicular atrophy (HP:0000029)1.89240438
142Pancreatic fibrosis (HP:0100732)1.88334616
143Abnormality of the preputium (HP:0100587)1.85630515
144Small intestinal stenosis (HP:0012848)1.81581214
145Duodenal stenosis (HP:0100867)1.81581214
146Diaphragmatic weakness (HP:0009113)1.81214227
147Myokymia (HP:0002411)1.79024103
148Asplenia (HP:0001746)1.78427285
149Abnormality of reticulocytes (HP:0004312)1.71628179
150Rimmed vacuoles (HP:0003805)1.70945649
151Cerebral palsy (HP:0100021)1.70214348
152Rectovaginal fistula (HP:0000143)1.70177668
153Rectal fistula (HP:0100590)1.70177668
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67335661
155Abnormal protein N-linked glycosylation (HP:0012347)1.67335661
156Abnormal protein glycosylation (HP:0012346)1.67335661
157Abnormal glycosylation (HP:0012345)1.67335661
158Birth length less than 3rd percentile (HP:0003561)1.66921701
159Cortical dysplasia (HP:0002539)1.66820222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.64983575
2VRK24.33422441
3PDK34.30526585
4PDK44.30526585
5OBSCN3.58989904
6MYLK3.16513514
7CDC73.09892039
8TTN3.02819587
9NEK13.01089657
10PHKG22.93434907
11PHKG12.93434907
12PINK12.81242176
13LMTK22.75045073
14NME22.40391142
15TRIB32.40378896
16PDK22.39791359
17PKN22.18443841
18NME12.11302726
19MUSK1.88126796
20SRPK11.85033805
21MAP3K111.72554649
22MAP4K21.68520272
23PLK11.66880620
24TESK21.66381623
25PBK1.62484965
26VRK11.55685669
27WNK41.52313885
28TIE11.41578448
29ARAF1.37533334
30PIM21.36120220
31CDK81.31295997
32KDR1.30281760
33BRSK11.30135769
34SCYL21.28608963
35EIF2AK11.26493822
36STK161.26027484
37ERN11.22687245
38INSRR1.21404709
39MAP2K31.18931438
40AURKA1.18713417
41MAP2K41.17660251
42TTK1.14599612
43STK38L1.14170344
44PLK31.13384372
45STK241.12714499
46FLT31.11586054
47AURKB1.11001935
48ATR1.09798124
49PRKCI1.09090343
50ILK1.07047436
51CSNK1G31.06812603
52MKNK21.06138083
53PIK3CA1.05240132
54CHEK21.02565933
55PIK3CG1.02561823
56NEK21.00950498
57MAP3K120.99385931
58STK390.99333645
59MAPKAPK30.98996556
60CSNK1G20.94515607
61RPS6KA40.94245530
62DAPK30.93781201
63TAOK20.88851906
64BMPR1B0.88597284
65CDK70.88059588
66GRK70.87095079
67TLK10.86924047
68MKNK10.84993081
69MAP3K100.84530258
70SIK10.84155565
71MAPK120.83771934
72MAP2K60.83477020
73BRAF0.81577849
74CAMK2D0.77902338
75CAMK2G0.75696884
76BUB10.72222604
77ZAK0.72195221
78DYRK20.72142254
79MAP3K50.71534083
80CSNK1G10.71515375
81NEK90.71514144
82MAPK110.71505458
83PRKAA10.70744461
84WNK30.70078724
85ABL20.67758998
86CSNK2A20.67601360
87EPHA40.66938668
88MAPKAPK50.63960184
89CSNK1A1L0.63038566
90CDK11A0.62572222
91RPS6KA50.62069865
92PRKAA20.60774618
93CHEK10.60087822
94NUAK10.59957524
95DAPK10.59148782
96MAP2K70.57511698
97RPS6KB20.57466033
98CDK150.57161011
99CDK140.57035920
100MAP3K70.56649085
101CDK180.54544427
102CDK10.52522085
103PAK30.52474120
104CDK40.52254249
105MAP3K30.51625285
106CAMKK20.49056197
107PRKACG0.48149726
108CSNK1A10.47973802
109DAPK20.47072190
110CAMK2A0.46088552
111MINK10.45372828
112TRIM280.45142315
113MAP3K80.45129852
114PRKACA0.45033891
115PRKD10.44856235
116CDK20.44190426
117MAP2K10.43096247
118FGFR40.42770076
119ATM0.41697681
120IRAK30.41044611
121EIF2AK30.39116410
122LRRK20.38757779
123PAK10.38496670
124CSNK1E0.36523225
125PLK40.36152189
126PDPK10.35144389
127PAK60.33021977
128AKT20.32783276
129CAMK10.31593155
130STK40.31435415
131CAMK40.31309906
132PDK10.29453707
133CCNB10.29036191
134MST1R0.28768813
135PRKCG0.28024377
136ROCK10.26883231
137MAP3K40.26318190
138TESK10.26063097
139ACVR1B0.25969175
140PRKACB0.24810135
141CDC42BPA0.23084096
142MAP3K10.22717987
143GRK50.22599729
144DMPK0.22535805
145PRKG20.22113795
146STK380.21849152
147LIMK10.19308082
148WEE10.17366969
149CDK190.16591684
150SGK20.14796560
151SGK2230.14172937
152SGK4940.14172937
153RPS6KC10.13544728
154RPS6KL10.13544728
155CSNK2A10.13112391
156PRKCA0.13047623

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.66551072
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.72172284
3Propanoate metabolism_Homo sapiens_hsa006403.50113323
4Base excision repair_Homo sapiens_hsa034103.16306285
5Fatty acid degradation_Homo sapiens_hsa000713.14856829
6DNA replication_Homo sapiens_hsa030303.10122975
7* Oxidative phosphorylation_Homo sapiens_hsa001903.04677185
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.04029525
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97820844
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.97813517
11Parkinsons disease_Homo sapiens_hsa050122.84469840
12Carbon metabolism_Homo sapiens_hsa012002.53969796
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48308663
14Mismatch repair_Homo sapiens_hsa034302.47137741
15Pyruvate metabolism_Homo sapiens_hsa006202.43412195
16Fatty acid metabolism_Homo sapiens_hsa012122.37772742
17Butanoate metabolism_Homo sapiens_hsa006502.22484275
18Non-homologous end-joining_Homo sapiens_hsa034502.11340705
19Cardiac muscle contraction_Homo sapiens_hsa042602.08796092
20Homologous recombination_Homo sapiens_hsa034402.08046315
21Primary bile acid biosynthesis_Homo sapiens_hsa001202.03997548
22Alzheimers disease_Homo sapiens_hsa050101.99308098
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96834408
24* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91090675
25Huntingtons disease_Homo sapiens_hsa050161.83656238
26Peroxisome_Homo sapiens_hsa041461.82675615
27Tryptophan metabolism_Homo sapiens_hsa003801.82061532
28Fanconi anemia pathway_Homo sapiens_hsa034601.80599793
29Spliceosome_Homo sapiens_hsa030401.76602774
30Arginine biosynthesis_Homo sapiens_hsa002201.75387679
31Biosynthesis of amino acids_Homo sapiens_hsa012301.73255626
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71450288
33PPAR signaling pathway_Homo sapiens_hsa033201.67050486
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64450643
35Nucleotide excision repair_Homo sapiens_hsa034201.64290158
36Fatty acid elongation_Homo sapiens_hsa000621.59185756
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57496513
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56817309
39beta-Alanine metabolism_Homo sapiens_hsa004101.56335699
40RNA transport_Homo sapiens_hsa030131.53127848
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50019341
42Nitrogen metabolism_Homo sapiens_hsa009101.43646431
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40767735
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29749880
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25606175
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18176009
47Starch and sucrose metabolism_Homo sapiens_hsa005001.12787084
48Phenylalanine metabolism_Homo sapiens_hsa003601.12470263
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11697278
50Proteasome_Homo sapiens_hsa030501.10063905
51Folate biosynthesis_Homo sapiens_hsa007901.08644284
52RNA degradation_Homo sapiens_hsa030181.07755926
53Sulfur metabolism_Homo sapiens_hsa009201.06030961
54Sulfur relay system_Homo sapiens_hsa041221.04049313
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99511605
56Basal transcription factors_Homo sapiens_hsa030220.97808611
57Selenocompound metabolism_Homo sapiens_hsa004500.95254862
58Cell cycle_Homo sapiens_hsa041100.93713442
59Pentose phosphate pathway_Homo sapiens_hsa000300.93303375
60Fructose and mannose metabolism_Homo sapiens_hsa000510.93136405
61Tyrosine metabolism_Homo sapiens_hsa003500.91661982
62Arginine and proline metabolism_Homo sapiens_hsa003300.91549421
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91254800
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.91106649
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90701080
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87852026
67Fat digestion and absorption_Homo sapiens_hsa049750.83539833
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80819566
69Chemical carcinogenesis_Homo sapiens_hsa052040.80740897
70Galactose metabolism_Homo sapiens_hsa000520.80638447
71Caffeine metabolism_Homo sapiens_hsa002320.79395985
72* Metabolic pathways_Homo sapiens_hsa011000.78241275
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73947864
74Complement and coagulation cascades_Homo sapiens_hsa046100.70069523
75Glutathione metabolism_Homo sapiens_hsa004800.69798002
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68252887
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.66429128
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64828224
79Bile secretion_Homo sapiens_hsa049760.64606725
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64353530
81Dilated cardiomyopathy_Homo sapiens_hsa054140.63982289
82Glycerolipid metabolism_Homo sapiens_hsa005610.62493404
83Synaptic vesicle cycle_Homo sapiens_hsa047210.61623384
84Ribosome_Homo sapiens_hsa030100.58576282
85Glucagon signaling pathway_Homo sapiens_hsa049220.58478109
86Steroid biosynthesis_Homo sapiens_hsa001000.57952939
87Fatty acid biosynthesis_Homo sapiens_hsa000610.56642343
88Histidine metabolism_Homo sapiens_hsa003400.55219572
89Oocyte meiosis_Homo sapiens_hsa041140.54668978
90Retinol metabolism_Homo sapiens_hsa008300.53369062
91mRNA surveillance pathway_Homo sapiens_hsa030150.50847494
92N-Glycan biosynthesis_Homo sapiens_hsa005100.47961373
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45158617
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.44229656
95Vitamin B6 metabolism_Homo sapiens_hsa007500.41298112
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.41170613
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.41018411
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37979774
99Vibrio cholerae infection_Homo sapiens_hsa051100.36632216
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36477841
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36048275
102Insulin resistance_Homo sapiens_hsa049310.35779201
103Insulin signaling pathway_Homo sapiens_hsa049100.34043115
104Pyrimidine metabolism_Homo sapiens_hsa002400.29895011
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28670285
106ABC transporters_Homo sapiens_hsa020100.27010807
107AMPK signaling pathway_Homo sapiens_hsa041520.26156081
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22657367
109Lysine degradation_Homo sapiens_hsa003100.21890773
110Olfactory transduction_Homo sapiens_hsa047400.21855344
111Vitamin digestion and absorption_Homo sapiens_hsa049770.21815640
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21724772
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19855388
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19775176
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16742587
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16571784
117Purine metabolism_Homo sapiens_hsa002300.16495680
118RNA polymerase_Homo sapiens_hsa030200.16044645
119One carbon pool by folate_Homo sapiens_hsa006700.14233774
120p53 signaling pathway_Homo sapiens_hsa041150.13546346
121Protein export_Homo sapiens_hsa030600.13231029
122Regulation of autophagy_Homo sapiens_hsa041400.12720942
123Epstein-Barr virus infection_Homo sapiens_hsa051690.12483291
124Systemic lupus erythematosus_Homo sapiens_hsa053220.12192783
125Collecting duct acid secretion_Homo sapiens_hsa049660.09954454
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06004639
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.05090627
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03947509
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.03933489
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.02571602
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02351447
132Calcium signaling pathway_Homo sapiens_hsa040200.00577003

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