NDUFB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ncRNA 3-end processing (GO:0043628)9.63044318
2ATP synthesis coupled proton transport (GO:0015986)9.51152914
3energy coupled proton transport, down electrochemical gradient (GO:0015985)9.51152914
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.14449824
5* respiratory electron transport chain (GO:0022904)8.46006205
6* electron transport chain (GO:0022900)8.23790680
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)7.63561701
8oxidative phosphorylation (GO:0006119)5.83698545
9ATP biosynthetic process (GO:0006754)5.37809192
10sarcomere organization (GO:0045214)5.26381569
11hydrogen ion transmembrane transport (GO:1902600)4.96185575
12GMP metabolic process (GO:0046037)4.95383260
13protein complex biogenesis (GO:0070271)4.94002025
14tricarboxylic acid cycle (GO:0006099)4.92463662
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.87935324
16ribosomal large subunit biogenesis (GO:0042273)4.86387034
17chaperone-mediated protein transport (GO:0072321)4.85770079
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.81368722
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.81368722
20NADH dehydrogenase complex assembly (GO:0010257)4.81368722
21purine nucleoside triphosphate biosynthetic process (GO:0009145)4.80745498
22ribonucleoprotein complex biogenesis (GO:0022613)4.79417204
23inner mitochondrial membrane organization (GO:0007007)4.71789846
24viral life cycle (GO:0019058)4.63840449
25actin-myosin filament sliding (GO:0033275)4.61243952
26muscle filament sliding (GO:0030049)4.61243952
27heart contraction (GO:0060047)4.57064449
28heart process (GO:0003015)4.57064449
29mitochondrial respiratory chain complex assembly (GO:0033108)4.56740337
30cellular component biogenesis (GO:0044085)4.55746217
31protein neddylation (GO:0045116)4.46947499
32cellular protein complex disassembly (GO:0043624)4.44617365
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.37689966
34regulation of oxidative phosphorylation (GO:0002082)4.35912391
35ribonucleoside triphosphate biosynthetic process (GO:0009201)4.34118546
36pyrimidine-containing compound salvage (GO:0008655)4.32433122
37pyrimidine nucleoside salvage (GO:0043097)4.32433122
38proton transport (GO:0015992)4.31700934
39hydrogen transport (GO:0006818)4.22932614
40inositol phosphate dephosphorylation (GO:0046855)4.18939920
41phosphorylated carbohydrate dephosphorylation (GO:0046838)4.18939920
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.13094888
43tricarboxylic acid metabolic process (GO:0072350)4.06414395
442-oxoglutarate metabolic process (GO:0006103)4.04162429
45regulation of sister chromatid cohesion (GO:0007063)3.98562819
46quinone biosynthetic process (GO:1901663)3.90096642
47ubiquinone biosynthetic process (GO:0006744)3.90096642
48cardiac myofibril assembly (GO:0055003)3.86518270
49translational initiation (GO:0006413)3.85232933
50myofibril assembly (GO:0030239)3.84749514
51DNA deamination (GO:0045006)3.81757862
52nucleoside salvage (GO:0043174)3.81548029
53ribosomal small subunit biogenesis (GO:0042274)3.76766138
54prostanoid biosynthetic process (GO:0046457)3.75761111
55prostaglandin biosynthetic process (GO:0001516)3.75761111
56nucleoside triphosphate biosynthetic process (GO:0009142)3.75356880
57regulation of mitochondrial translation (GO:0070129)3.73732290
58inositol phosphate catabolic process (GO:0071545)3.73107541
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72216439
60regulation of cellular respiration (GO:0043457)3.70842820
61RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.70456082
62protein complex disassembly (GO:0043241)3.68845985
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68500887
64aerobic respiration (GO:0009060)3.67765267
65mitochondrial transport (GO:0006839)3.66897466
66actin-mediated cell contraction (GO:0070252)3.66175476
67regulation of relaxation of muscle (GO:1901077)3.61592751
68cardiac muscle tissue morphogenesis (GO:0055008)3.56333481
69viral transcription (GO:0019083)3.56020646
70primary alcohol catabolic process (GO:0034310)3.55093185
71intracellular protein transmembrane import (GO:0044743)3.54933888
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54257176
73ubiquinone metabolic process (GO:0006743)3.53653884
74proteasome assembly (GO:0043248)3.50437407
75protein import into peroxisome matrix (GO:0016558)3.50242728
76ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.47274453
77cardiac muscle contraction (GO:0060048)3.45797310
78NADH metabolic process (GO:0006734)3.45602958
79regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.45194218
80sequestering of actin monomers (GO:0042989)3.43736149
81macromolecular complex disassembly (GO:0032984)3.41890391
82purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.40251935
83purine nucleoside monophosphate biosynthetic process (GO:0009127)3.40251935
84protein targeting to mitochondrion (GO:0006626)3.39121823
85pseudouridine synthesis (GO:0001522)3.38790854
86respiratory chain complex IV assembly (GO:0008535)3.37335693
87response to muscle activity (GO:0014850)3.37007264
88establishment of protein localization to mitochondrion (GO:0072655)3.36612007
89regulation of actin filament-based movement (GO:1903115)3.35403382
90translational termination (GO:0006415)3.34708512
91purine-containing compound salvage (GO:0043101)3.34304882
92regulation of G0 to G1 transition (GO:0070316)3.33970719
93protein targeting to membrane (GO:0006612)3.32878186
94cytochrome complex assembly (GO:0017004)3.31781486
95maturation of SSU-rRNA (GO:0030490)3.29734410
96* generation of precursor metabolites and energy (GO:0006091)3.24929488
97ribosomal small subunit assembly (GO:0000028)3.22766192
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21887116
99cytidine catabolic process (GO:0006216)3.21828864
100cytidine deamination (GO:0009972)3.21828864
101cytidine metabolic process (GO:0046087)3.21828864
102rRNA processing (GO:0006364)3.21251252
103regulation of skeletal muscle contraction (GO:0014819)3.20826508
104cardiac muscle cell development (GO:0055013)3.20768303
105regulation of acyl-CoA biosynthetic process (GO:0050812)3.20702721
106muscle tissue morphogenesis (GO:0060415)3.20419321
107regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.18980697
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.16673322
109cotranslational protein targeting to membrane (GO:0006613)3.16610781
110adult heart development (GO:0007512)3.15289590
111regulation of cell communication by electrical coupling (GO:0010649)3.15247234
112protein targeting to ER (GO:0045047)3.13674804
113GTP biosynthetic process (GO:0006183)3.13376784
114protein maturation by protein folding (GO:0022417)3.12411506
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12096786
116negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11610977
117negative regulation of protein localization to cell surface (GO:2000009)3.10468245
118negative regulation of potassium ion transmembrane transport (GO:1901380)3.08339191
119phosphatidylglycerol biosynthetic process (GO:0006655)3.08275642
120protein localization to mitochondrion (GO:0070585)3.07091256
121regulation of cellular amino acid metabolic process (GO:0006521)3.05820302
122negative regulation of B cell apoptotic process (GO:0002903)3.03838322
123rRNA metabolic process (GO:0016072)3.03768879
124protein localization to endoplasmic reticulum (GO:0070972)3.02356768
125transcription elongation from RNA polymerase III promoter (GO:0006385)3.01834344
126termination of RNA polymerase III transcription (GO:0006386)3.01834344
127succinate metabolic process (GO:0006105)3.01037222
128establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00936921
129heart trabecula formation (GO:0060347)2.99945861
130translational elongation (GO:0006414)2.95961533
131cardiac cell development (GO:0055006)2.94880569
132purine ribonucleoside biosynthetic process (GO:0046129)2.93626435
133purine nucleoside biosynthetic process (GO:0042451)2.93626435
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92693448
135negative regulation of Ras GTPase activity (GO:0034261)2.91789755
136creatine metabolic process (GO:0006600)2.91070512
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.90368173
138sarcoplasmic reticulum calcium ion transport (GO:0070296)2.90331507
139regulation of coenzyme metabolic process (GO:0051196)2.90121164
140regulation of cofactor metabolic process (GO:0051193)2.90121164
141pyrimidine nucleotide catabolic process (GO:0006244)2.86842308
142striated muscle contraction (GO:0006941)2.86370345
143regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86284188
144deoxyribonucleotide catabolic process (GO:0009264)2.82413706
145translation (GO:0006412)2.82275578
146regulation of cholesterol biosynthetic process (GO:0045540)2.82001908
147iron-sulfur cluster assembly (GO:0016226)2.81694366
148metallo-sulfur cluster assembly (GO:0031163)2.81694366
149mitochondrion morphogenesis (GO:0070584)2.81616482
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81265635
151pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76026370
152mRNA catabolic process (GO:0006402)2.71018550
153intracellular protein transmembrane transport (GO:0065002)2.69615449
154negative regulation of ligase activity (GO:0051352)2.69000340
155mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.1440825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.00368365
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33707729
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00376881
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83401674
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71630854
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.71281546
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.55603569
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.50726656
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42742701
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.36036950
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.33050272
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.24458025
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06478883
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77120307
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74928569
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.74926344
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57048725
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55721336
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.52876006
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.48637532
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.43609133
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24256923
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11779473
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.03305620
25DCP1A_22483619_ChIP-Seq_HELA_Human1.90173086
26BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.86010133
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82988573
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76070820
29* VDR_23849224_ChIP-Seq_CD4+_Human1.70665570
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70505909
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68930702
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65925742
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52897535
34XRN2_22483619_ChIP-Seq_HELA_Human1.51993926
35* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.49124859
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46088034
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.45748365
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44951831
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.43962519
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43637778
41ZNF263_19887448_ChIP-Seq_K562_Human1.41300728
42FOXP1_21924763_ChIP-Seq_HESCs_Human1.40542750
43LXR_22292898_ChIP-Seq_THP-1_Human1.39087630
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38101473
45FOXP3_21729870_ChIP-Seq_TREG_Human1.37509102
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.37398890
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.37104121
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34263757
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33999483
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32905954
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31215195
52CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.29520813
53BCOR_27268052_Chip-Seq_Bcells_Human1.27384482
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27027623
55TTF2_22483619_ChIP-Seq_HELA_Human1.26179846
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26045593
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25718425
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25648362
59P68_20966046_ChIP-Seq_HELA_Human1.25302778
60KDM5A_27292631_Chip-Seq_BREAST_Human1.24172690
61PHF8_20622854_ChIP-Seq_HELA_Human1.23634173
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21554228
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20824119
64EGR1_19032775_ChIP-ChIP_M12_Human1.20808260
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20357599
66* GABP_19822575_ChIP-Seq_HepG2_Human1.20350852
67E2F1_20622854_ChIP-Seq_HELA_Human1.18715977
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17927523
69STAT1_20625510_ChIP-Seq_HELA_Human1.17867076
70VDR_22108803_ChIP-Seq_LS180_Human1.17068880
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12905274
72ELK1_19687146_ChIP-ChIP_HELA_Human1.12701271
73VDR_21846776_ChIP-Seq_THP-1_Human1.12485339
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09633390
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.09612282
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08553643
77* SA1_27219007_Chip-Seq_ERYTHROID_Human1.07984639
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06265785
79P300_27268052_Chip-Seq_Bcells_Human1.05798187
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05269984
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04889169
82EZH2_22144423_ChIP-Seq_EOC_Human1.04336598
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02205746
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02047204
85NANOG_20526341_ChIP-Seq_ESCs_Human1.00884877
86SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00795567
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.00432262
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00250116
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00088957
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99035652
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98828362
92SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98344433
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98229473
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98212089
95SPI1_20517297_ChIP-Seq_HL60_Human0.97144219
96BCL6_27268052_Chip-Seq_Bcells_Human0.97032639
97* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96810175
98* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96473122
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96023642
100ERA_21632823_ChIP-Seq_H3396_Human0.95600327
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95020728
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91842341
103CTCF_26484167_Chip-Seq_Bcells_Mouse0.91473050
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90315054
105LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88923740
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88875064
107* CTCF_27219007_Chip-Seq_Bcells_Human0.87851408
108GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87685594
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87452546
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87373621
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87135568
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87125957
113NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86619905
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86355296
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85995806
116RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85599053
117SA1_27219007_Chip-Seq_Bcells_Human0.85256424
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85225915
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.84937196
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83434712
121CTCF_20526341_ChIP-Seq_ESCs_Human0.83084561
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82715231
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82629009
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.80897059
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80295857
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80055093
127* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79757893
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79215278
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78820509
130ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76887910
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75597872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.69691493
2MP0003646_muscle_fatigue6.26187972
3MP0003879_abnormal_hair_cell4.26954511
4MP0006082_CNS_inflammation4.23022163
5MP0000751_myopathy4.05777503
6MP0001873_stomach_inflammation4.00748121
7MP0000749_muscle_degeneration3.99132290
8MP0004084_abnormal_cardiac_muscle3.95984542
9MP0004036_abnormal_muscle_relaxation3.74689480
10MP0004215_abnormal_myocardial_fiber3.53926570
11MP0006036_abnormal_mitochondrial_physio3.22654450
12MP0005330_cardiomyopathy3.21446504
13MP0003121_genomic_imprinting2.76068931
14MP0003137_abnormal_impulse_conducting2.49106379
15MP0009780_abnormal_chondrocyte_physiolo2.46541737
16MP0001529_abnormal_vocalization2.46334106
17MP0002972_abnormal_cardiac_muscle2.46247701
18MP0003806_abnormal_nucleotide_metabolis2.39049085
19MP0000750_abnormal_muscle_regeneration2.18215781
20MP0006035_abnormal_mitochondrial_morpho2.12292512
21MP0002106_abnormal_muscle_physiology2.11331623
22MP0009379_abnormal_foot_pigmentation2.11315843
23MP0004087_abnormal_muscle_fiber2.10544855
24MP0005620_abnormal_muscle_contractility2.06223142
25MP0005075_abnormal_melanosome_morpholog2.04668010
26MP0006292_abnormal_olfactory_placode2.02109696
27MP0005385_cardiovascular_system_phenoty1.94882668
28MP0001544_abnormal_cardiovascular_syste1.94882668
29MP0002332_abnormal_exercise_endurance1.91282775
30MP0008775_abnormal_heart_ventricle1.89661326
31MP0009333_abnormal_splenocyte_physiolog1.83500725
32MP0002933_joint_inflammation1.81691307
33MP0001905_abnormal_dopamine_level1.78623885
34MP0002269_muscular_atrophy1.78125298
35MP0004145_abnormal_muscle_electrophysio1.77125588
36MP0003693_abnormal_embryo_hatching1.66558503
37MP0006138_congestive_heart_failure1.65905588
38MP0005369_muscle_phenotype1.64652054
39MP0004130_abnormal_muscle_cell1.61596996
40MP0000747_muscle_weakness1.56870180
41MP0004085_abnormal_heartbeat1.56550675
42MP0004484_altered_response_of1.54590450
43MP0000759_abnormal_skeletal_muscle1.51438701
44MP0003186_abnormal_redox_activity1.51205218
45MP0000015_abnormal_ear_pigmentation1.45142292
46MP0006276_abnormal_autonomic_nervous1.42766543
47MP0003950_abnormal_plasma_membrane1.41986958
48MP0005379_endocrine/exocrine_gland_phen1.41606725
49MP0010630_abnormal_cardiac_muscle1.38124470
50MP0005451_abnormal_body_composition1.36659014
51MP0003828_pulmonary_edema1.34029350
52MP0003221_abnormal_cardiomyocyte_apopto1.32236903
53MP0004510_myositis1.31991017
54MP0003011_delayed_dark_adaptation1.28162935
55MP0005266_abnormal_metabolism1.26515721
56MP0003123_paternal_imprinting1.23316518
57MP0004142_abnormal_muscle_tone1.20234960
58MP0004043_abnormal_pH_regulation1.18679324
59MP0005174_abnormal_tail_pigmentation1.16572332
60MP0004147_increased_porphyrin_level1.16389439
61MP0002127_abnormal_cardiovascular_syste1.13060493
62MP0005646_abnormal_pituitary_gland1.11753891
63MP0001727_abnormal_embryo_implantation1.11004259
64MP0000343_altered_response_to1.09542303
65MP0003195_calcinosis1.06075814
66MP0003880_abnormal_central_pattern1.05616303
67MP0001968_abnormal_touch/_nociception1.04991526
68MP0005083_abnormal_biliary_tract1.04830531
69MP0005165_increased_susceptibility_to0.99448037
70MP0002095_abnormal_skin_pigmentation0.98877838
71MP0000230_abnormal_systemic_arterial0.93575119
72MP0005381_digestive/alimentary_phenotyp0.92905209
73MP0005332_abnormal_amino_acid0.92219202
74MP0003786_premature_aging0.92051585
75MP0005535_abnormal_body_temperature0.88973647
76MP0005670_abnormal_white_adipose0.86822263
77MP0003136_yellow_coat_color0.86750987
78MP0005671_abnormal_response_to0.85527196
79MP0002277_abnormal_respiratory_mucosa0.85360521
80MP0005551_abnormal_eye_electrophysiolog0.85179134
81MP0009765_abnormal_xenobiotic_induced0.83740056
82MP0002822_catalepsy0.82615210
83MP0001851_eye_inflammation0.82493706
84MP0005636_abnormal_mineral_homeostasis0.80636305
85MP0002234_abnormal_pharynx_morphology0.78560735
86MP0005084_abnormal_gallbladder_morpholo0.78409493
87MP0000372_irregular_coat_pigmentation0.77615882
88MP0002160_abnormal_reproductive_system0.77040457
89MP0009785_altered_susceptibility_to0.75871389
90MP0005376_homeostasis/metabolism_phenot0.75097987
91MP0008058_abnormal_DNA_repair0.73916173
92MP0005584_abnormal_enzyme/coenzyme_acti0.73531014
93MP0001853_heart_inflammation0.73080756
94MP0002638_abnormal_pupillary_reflex0.72356435
95MP0000026_abnormal_inner_ear0.72352172
96MP0000920_abnormal_myelination0.71731670
97MP0008995_early_reproductive_senescence0.71478969
98MP0003656_abnormal_erythrocyte_physiolo0.70940317
99MP0005645_abnormal_hypothalamus_physiol0.69784853
100MP0001986_abnormal_taste_sensitivity0.68791015
101MP0008872_abnormal_physiological_respon0.68755635
102MP0001764_abnormal_homeostasis0.68443353
103MP0003718_maternal_effect0.68105054
104MP0001661_extended_life_span0.68001979
105MP0002272_abnormal_nervous_system0.67800242
106MP0002148_abnormal_hypersensitivity_rea0.67640858
107MP0004924_abnormal_behavior0.67441734
108MP0005386_behavior/neurological_phenoty0.67441734
109MP0002108_abnormal_muscle_morphology0.66712708
110MP0001984_abnormal_olfaction0.66701427
111MP0003938_abnormal_ear_development0.65545829
112MP0005409_darkened_coat_color0.65496870
113MP0000678_abnormal_parathyroid_gland0.64738313
114MP0009764_decreased_sensitivity_to0.63895148
115MP0000538_abnormal_urinary_bladder0.62944834
116MP0010030_abnormal_orbit_morphology0.62343431
117MP0001485_abnormal_pinna_reflex0.61313111
118MP0009643_abnormal_urine_homeostasis0.61079274
119MP0000049_abnormal_middle_ear0.60458150
120MP0005319_abnormal_enzyme/_coenzyme0.59732164
121MP0003567_abnormal_fetal_cardiomyocyte0.59715616
122MP0000681_abnormal_thyroid_gland0.57777947
123MP0008469_abnormal_protein_level0.57721136
124MP0001963_abnormal_hearing_physiology0.57144475
125MP0006072_abnormal_retinal_apoptosis0.56333105
126MP0002736_abnormal_nociception_after0.55785068
127MP0002163_abnormal_gland_morphology0.54761449
128MP0003329_amyloid_beta_deposits0.53814926
129MP0008789_abnormal_olfactory_epithelium0.53462376
130MP0001533_abnormal_skeleton_physiology0.52909345
131MP0005666_abnormal_adipose_tissue0.52638399
132MP0001756_abnormal_urination0.51545486
133MP0002229_neurodegeneration0.50069447
134MP0001970_abnormal_pain_threshold0.49670669
135MP0002132_abnormal_respiratory_system0.49430994
136MP0008875_abnormal_xenobiotic_pharmacok0.48838228
137MP0001440_abnormal_grooming_behavior0.48257132
138MP0002139_abnormal_hepatobiliary_system0.48218961
139MP0001663_abnormal_digestive_system0.47405287
140MP0001664_abnormal_digestion0.47007991
141MP0009840_abnormal_foam_cell0.46954166
142MP0002735_abnormal_chemical_nociception0.45727542
143MP0003724_increased_susceptibility_to0.45604722
144MP0004133_heterotaxia0.44846278
145MP0000013_abnormal_adipose_tissue0.44448995
146MP0005085_abnormal_gallbladder_physiolo0.44434082
147MP0002876_abnormal_thyroid_physiology0.44255229
148MP0002078_abnormal_glucose_homeostasis0.43340649
149MP0005408_hypopigmentation0.42607033
150MP0000358_abnormal_cell_content/0.42034890
151MP0005410_abnormal_fertilization0.38695989

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)7.28550487
2Acute necrotizing encephalopathy (HP:0006965)7.04127061
3Abnormal mitochondria in muscle tissue (HP:0008316)6.58560755
4Mitochondrial inheritance (HP:0001427)6.33210700
5Abnormality of macular pigmentation (HP:0008002)6.07460568
6Acute encephalopathy (HP:0006846)5.98719996
7Constricted visual fields (HP:0001133)5.82736821
8Progressive macrocephaly (HP:0004481)5.75320906
9Metaphyseal cupping (HP:0003021)5.66555615
10Hepatocellular necrosis (HP:0001404)5.64506035
11Hepatic necrosis (HP:0002605)5.50669497
12Striae distensae (HP:0001065)5.47173429
13Increased CSF lactate (HP:0002490)5.43317922
14Cupped ribs (HP:0000887)4.87609610
15Sudden death (HP:0001699)4.81410780
16Decreased electroretinogram (ERG) amplitude (HP:0000654)4.69113291
17Cerebral edema (HP:0002181)4.59736230
18Increased hepatocellular lipid droplets (HP:0006565)4.58438851
19Toxemia of pregnancy (HP:0100603)4.51081094
20Lipid accumulation in hepatocytes (HP:0006561)4.49610994
21Volvulus (HP:0002580)4.39702961
22Increased intramyocellular lipid droplets (HP:0012240)4.36064268
23Cone-rod dystrophy (HP:0000548)4.29897961
24Ventricular tachycardia (HP:0004756)4.24482694
25Increased muscle lipid content (HP:0009058)4.22265037
26Calf muscle hypertrophy (HP:0008981)4.21257000
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.13059214
28Muscle hypertrophy of the lower extremities (HP:0008968)4.11343854
29Exercise intolerance (HP:0003546)4.11197251
30Respiratory failure (HP:0002878)3.99294886
31Lactic acidosis (HP:0003128)3.97951620
32Increased serum pyruvate (HP:0003542)3.90127927
33Abnormality of glycolysis (HP:0004366)3.90127927
34Optic disc pallor (HP:0000543)3.84575353
35Renal Fanconi syndrome (HP:0001994)3.84412574
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.75944296
37Decreased activity of mitochondrial respiratory chain (HP:0008972)3.75944296
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.63816370
39Attenuation of retinal blood vessels (HP:0007843)3.61440740
40Muscle fiber splitting (HP:0003555)3.45437393
41Increased serum lactate (HP:0002151)3.43999558
42Palpitations (HP:0001962)3.41304938
43Leukodystrophy (HP:0002415)3.39349259
44Exercise-induced myalgia (HP:0003738)3.37625456
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35817499
46Lipoatrophy (HP:0100578)3.25669300
47Hyperthyroidism (HP:0000836)3.23193613
48Exercise-induced muscle cramps (HP:0003710)3.19296726
49Exertional dyspnea (HP:0002875)3.15264285
50Myoglobinuria (HP:0002913)3.14521988
51Atrial fibrillation (HP:0005110)3.10629138
52Severe visual impairment (HP:0001141)3.05852659
533-Methylglutaconic aciduria (HP:0003535)3.04162264
54Abnormality of the calf musculature (HP:0001430)3.01225360
55Supraventricular tachycardia (HP:0004755)2.98745513
56Large earlobe (HP:0009748)2.91370461
57Primary atrial arrhythmia (HP:0001692)2.91278464
58Supraventricular arrhythmia (HP:0005115)2.90555853
59Rhabdomyolysis (HP:0003201)2.88781892
60Dilated cardiomyopathy (HP:0001644)2.85158232
61Neoplasm of head and neck (HP:0012288)2.82788995
62Esophageal neoplasm (HP:0100751)2.82788995
63Decreased muscle mass (HP:0003199)2.77606560
64Dicarboxylic aciduria (HP:0003215)2.75765970
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75765970
66Respiratory difficulties (HP:0002880)2.74970243
67Neuroendocrine neoplasm (HP:0100634)2.71293828
68Pheochromocytoma (HP:0002666)2.66697664
69Lethargy (HP:0001254)2.64688766
70Abnormality of urine glucose concentration (HP:0011016)2.62605677
71Glycosuria (HP:0003076)2.62605677
72Myotonia (HP:0002486)2.61776801
73CNS demyelination (HP:0007305)2.57550154
74Abnormality of fatty-acid metabolism (HP:0004359)2.55174394
75Prolonged QT interval (HP:0001657)2.50812947
76Syncope (HP:0001279)2.49735771
77Abnormality of renal resorption (HP:0011038)2.46885656
78Brushfield spots (HP:0001088)2.46748174
79Abnormality of cells of the erythroid lineage (HP:0012130)2.42214176
80Generalized aminoaciduria (HP:0002909)2.42187104
81Oligodontia (HP:0000677)2.41998448
82EMG: myopathic abnormalities (HP:0003458)2.41381338
83Subaortic stenosis (HP:0001682)2.40008797
84Abnormality of the left ventricular outflow tract (HP:0011103)2.40008797
85Aplasia/Hypoplasia of the earlobes (HP:0009906)2.37912939
86Lack of skin elasticity (HP:0100679)2.33911913
87Ovoid vertebral bodies (HP:0003300)2.33583406
88Muscle stiffness (HP:0003552)2.29627536
89Broad nasal tip (HP:0000455)2.26388743
90Concave nail (HP:0001598)2.22607522
91Hyporeflexia of lower limbs (HP:0002600)2.21497814
92Emotional lability (HP:0000712)2.20929615
93Femoral bowing (HP:0002980)2.19877433
94Conjunctival hamartoma (HP:0100780)2.19835580
95Abnormal number of erythroid precursors (HP:0012131)2.16712846
96Small hand (HP:0200055)2.15994059
97X-linked dominant inheritance (HP:0001423)2.14143238
98Aplastic anemia (HP:0001915)2.13674859
99Ragged-red muscle fibers (HP:0003200)2.11726710
100Vomiting (HP:0002013)2.10953862
101Hyperphosphaturia (HP:0003109)2.09795419
102Macrocytic anemia (HP:0001972)2.08260552
103Muscle fiber inclusion bodies (HP:0100299)2.07054119
104Tibial bowing (HP:0002982)2.05486395
105Prominent supraorbital ridges (HP:0000336)2.04296904
106Ventricular arrhythmia (HP:0004308)2.01104801
107Nemaline bodies (HP:0003798)2.00858749
108Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98983887
109Testicular atrophy (HP:0000029)1.98502129
110Right ventricular cardiomyopathy (HP:0011663)1.97589193
111Abnormality of lateral ventricle (HP:0030047)1.97048384
112Asymmetric septal hypertrophy (HP:0001670)1.96353143
113Coxa vara (HP:0002812)1.95419257
114Left ventricular hypertrophy (HP:0001712)1.94242455
115Hepatosplenomegaly (HP:0001433)1.90188719
116Ketoacidosis (HP:0001993)1.89450697
117Hyperglycinemia (HP:0002154)1.89164578
118Nausea (HP:0002018)1.86306472
119Hypoglycemic coma (HP:0001325)1.85649125
120IgM deficiency (HP:0002850)1.83708681
121Methylmalonic aciduria (HP:0012120)1.83148335
122Reticulocytopenia (HP:0001896)1.82295337
123Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82267415
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82230231
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82031018
126Myokymia (HP:0002411)1.81689852
127Palmoplantar keratoderma (HP:0000982)1.80841655
128Gliosis (HP:0002171)1.80196897
129Abnormal urine phosphate concentration (HP:0012599)1.77237432
130Oral leukoplakia (HP:0002745)1.76674252
131Abnormal EKG (HP:0003115)1.75050169
132Epiphyseal stippling (HP:0010655)1.75014024
133Multiple enchondromatosis (HP:0005701)1.74533780
134Recurrent otitis media (HP:0000403)1.74325858
135Cerebral hemorrhage (HP:0001342)1.72168102
136Blindness (HP:0000618)1.72074444
137Hypoplastic left heart (HP:0004383)1.71124442
138Neck muscle weakness (HP:0000467)1.70471986
139Proximal tubulopathy (HP:0000114)1.69153694
140Prenatal maternal abnormality (HP:0002686)1.67874969
141Ventricular fibrillation (HP:0001663)1.67150670
142Heart block (HP:0012722)1.66742932
143Abnormality of alanine metabolism (HP:0010916)1.66486348
144Hyperalaninemia (HP:0003348)1.66486348
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66486348
146Progressive visual loss (HP:0000529)1.64911185
147Sparse eyelashes (HP:0000653)1.62752162
148Type I transferrin isoform profile (HP:0003642)1.62668469
149Proximal placement of thumb (HP:0009623)1.61823919
150Rough bone trabeculation (HP:0100670)1.60216540
151Muscle fiber atrophy (HP:0100295)1.59780424
152Cerebral palsy (HP:0100021)1.59713823
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59696431
154Abnormality of magnesium homeostasis (HP:0004921)1.59486665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT5.94141476
2MYLK4.88863827
3NME23.95648195
4VRK23.36858209
5OBSCN3.33005537
6FES3.17456285
7BCKDK3.12322337
8NME13.08073196
9MAP3K122.98226829
10TTN2.58787003
11STK162.50136216
12PHKG12.36712805
13PHKG22.36712805
14MUSK2.31694115
15TEC2.29625006
16PIK3CA2.23023016
17LMTK22.16645081
18PBK2.16501883
19GRK72.04236900
20LIMK12.02534575
21STK391.89838110
22PDK31.80821781
23PDK41.80821781
24CDK191.72076262
25IKBKB1.70691763
26WNK41.68652202
27TLK11.68362685
28BUB11.66091239
29DAPK31.63724123
30ARAF1.54137410
31ILK1.49742620
32KDR1.44139894
33TESK21.42212773
34TIE11.38815243
35MAP4K21.32915456
36CAMK2D1.31400062
37PIM21.27836256
38SIK21.24637620
39MAP3K111.21210947
40PINK11.12725550
41MAP4K11.08608122
42ABL21.05095596
43PDK21.03685492
44MST41.03406553
45OXSR11.02894940
46GRK50.99515173
47ROCK20.98593265
48TBK10.97888396
49TESK10.95277634
50PRPF4B0.94312035
51ZAK0.93755180
52SYK0.93283650
53PKN10.92918001
54RPS6KB20.91340859
55EIF2AK10.91229720
56VRK10.90260517
57BLK0.85634560
58ROCK10.85152743
59RPS6KL10.85040167
60RPS6KC10.85040167
61UHMK10.82594726
62TAOK20.80575700
63STK240.80439584
64SRPK10.77973061
65ADRBK20.77826328
66BRAF0.76969265
67RPS6KA60.76568903
68CDK30.76484458
69DYRK20.75180816
70STK40.74989479
71MST1R0.72890613
72RPS6KA50.72148924
73GRK10.69039667
74CAMK2G0.67280646
75BCR0.66413263
76CAMK2A0.64955273
77MAP2K70.64657394
78CSK0.64243753
79TYRO30.63418693
80CAMK2B0.61036402
81MAP2K20.60347619
82EIF2AK30.59210250
83MAPK120.58789821
84IKBKE0.58326418
85PRKACA0.56762757
86CCNB10.55898537
87IRAK40.55813699
88CSF1R0.55388727
89CDC70.55180742
90MAP2K60.53568788
91DAPK10.53018054
92IRAK30.52235558
93CSNK1G10.52184301
94WNK30.51742865
95WEE10.50990942
96PTK2B0.50565461
97PAK30.50224226
98CDC42BPA0.50146216
99INSRR0.49736304
100ADRBK10.49665757
101PRKD10.47779653
102NEK10.46644952
103EPHB20.46577669
104PRKCI0.46459177
105CSNK1G20.43896349
106NUAK10.43056888
107MAPK40.42839809
108AURKA0.42376122
109TNIK0.41458269
110RET0.41195314
111CASK0.40426110
112RPS6KA40.40338828
113MAPKAPK50.40058242
114INSR0.39345240
115PAK10.38881180
116PLK10.38783508
117PRKCE0.38614517
118PRKACB0.37749103
119SRC0.37727338
120GRK60.37542858
121CSNK2A20.37487187
122PRKCA0.37253772
123PIK3CG0.37136880
124AURKB0.36287110
125MAPKAPK30.35893832
126PAK40.35841773
127RPS6KA20.34970654
128TXK0.34712720
129PNCK0.34457084
130EPHA20.34129475
131PRKCQ0.32921958
132LRRK20.32227416
133CDK11A0.32204534
134DMPK0.32201320
135CSNK1A1L0.31988835
136FGR0.31496766
137CSNK2A10.31490454
138PRKCG0.31006990
139IRAK20.30743507
140IRAK10.30164382
141CSNK1G30.29919847
142CSNK1A10.29559785
143PRKACG0.27928115
144CDK80.26937234
145AKT20.24713040

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.41934719
2Parkinsons disease_Homo sapiens_hsa050125.73637156
3Alzheimers disease_Homo sapiens_hsa050104.20553057
4Huntingtons disease_Homo sapiens_hsa050163.88821332
5Cardiac muscle contraction_Homo sapiens_hsa042603.81593036
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.76633188
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.40321769
8Ribosome_Homo sapiens_hsa030103.24422980
9Proteasome_Homo sapiens_hsa030503.05078813
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15149452
11Propanoate metabolism_Homo sapiens_hsa006402.06202873
12Fatty acid elongation_Homo sapiens_hsa000621.89945299
13RNA polymerase_Homo sapiens_hsa030201.85798174
14Protein export_Homo sapiens_hsa030601.71851863
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68960598
16Pyruvate metabolism_Homo sapiens_hsa006201.64354881
17Carbon metabolism_Homo sapiens_hsa012001.63347100
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58771573
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58341642
20Phototransduction_Homo sapiens_hsa047441.51942803
21Fatty acid degradation_Homo sapiens_hsa000711.45667562
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31055614
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30178399
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25662405
25Butanoate metabolism_Homo sapiens_hsa006501.16561897
26Fatty acid metabolism_Homo sapiens_hsa012121.15228861
27Pyrimidine metabolism_Homo sapiens_hsa002401.12383233
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11582165
29Sulfur metabolism_Homo sapiens_hsa009201.06476016
30Collecting duct acid secretion_Homo sapiens_hsa049661.06304084
31Dilated cardiomyopathy_Homo sapiens_hsa054141.01100932
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98685121
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94480567
34* Metabolic pathways_Homo sapiens_hsa011000.94170125
35Phenylalanine metabolism_Homo sapiens_hsa003600.91353405
36Peroxisome_Homo sapiens_hsa041460.87607729
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87301658
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86955473
39Glutathione metabolism_Homo sapiens_hsa004800.84528842
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80801781
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78269210
42Tyrosine metabolism_Homo sapiens_hsa003500.77426366
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76546901
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73508727
45Arginine and proline metabolism_Homo sapiens_hsa003300.73489573
46beta-Alanine metabolism_Homo sapiens_hsa004100.71537559
47Sulfur relay system_Homo sapiens_hsa041220.69123714
48Biosynthesis of amino acids_Homo sapiens_hsa012300.64483138
49Fructose and mannose metabolism_Homo sapiens_hsa000510.62158307
50Purine metabolism_Homo sapiens_hsa002300.61176166
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61072208
52PPAR signaling pathway_Homo sapiens_hsa033200.60616118
53Tryptophan metabolism_Homo sapiens_hsa003800.57464937
54One carbon pool by folate_Homo sapiens_hsa006700.55131327
55DNA replication_Homo sapiens_hsa030300.54704764
56Vitamin B6 metabolism_Homo sapiens_hsa007500.54377892
57Arachidonic acid metabolism_Homo sapiens_hsa005900.54027688
58Galactose metabolism_Homo sapiens_hsa000520.53338554
59Ether lipid metabolism_Homo sapiens_hsa005650.52388523
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51934517
61Synaptic vesicle cycle_Homo sapiens_hsa047210.51549023
62Vibrio cholerae infection_Homo sapiens_hsa051100.51221454
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49952588
64Alcoholism_Homo sapiens_hsa050340.49639069
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49458710
66Pentose phosphate pathway_Homo sapiens_hsa000300.49375555
67Folate biosynthesis_Homo sapiens_hsa007900.49372923
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.48555910
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.45993130
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.44518066
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41675859
72Nucleotide excision repair_Homo sapiens_hsa034200.41178670
73Viral myocarditis_Homo sapiens_hsa054160.40738869
74Histidine metabolism_Homo sapiens_hsa003400.37959320
75Starch and sucrose metabolism_Homo sapiens_hsa005000.37864299
76Steroid biosynthesis_Homo sapiens_hsa001000.37309327
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35530306
78Rheumatoid arthritis_Homo sapiens_hsa053230.35442819
79Spliceosome_Homo sapiens_hsa030400.34094598
80Linoleic acid metabolism_Homo sapiens_hsa005910.33997219
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33350817
82Primary immunodeficiency_Homo sapiens_hsa053400.33304210
83Olfactory transduction_Homo sapiens_hsa047400.33123048
84RNA degradation_Homo sapiens_hsa030180.32999993
85Base excision repair_Homo sapiens_hsa034100.31526314
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30648912
87Graft-versus-host disease_Homo sapiens_hsa053320.30353017
88Caffeine metabolism_Homo sapiens_hsa002320.29241995
89Chemical carcinogenesis_Homo sapiens_hsa052040.28849350
90Arginine biosynthesis_Homo sapiens_hsa002200.28634634
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.28017739
92Nitrogen metabolism_Homo sapiens_hsa009100.26588152
93Mismatch repair_Homo sapiens_hsa034300.25183481
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.24080503
95Homologous recombination_Homo sapiens_hsa034400.23937287
96Fat digestion and absorption_Homo sapiens_hsa049750.23477957
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21563972
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.21396827
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19986332
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18028383
101Lysosome_Homo sapiens_hsa041420.17232713
102Fanconi anemia pathway_Homo sapiens_hsa034600.17159459
103Antigen processing and presentation_Homo sapiens_hsa046120.16288389
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16173456
105Allograft rejection_Homo sapiens_hsa053300.15755859
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15145054
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14575918
108Phagosome_Homo sapiens_hsa041450.12757457
109Regulation of autophagy_Homo sapiens_hsa041400.10774838
110Other glycan degradation_Homo sapiens_hsa005110.10294693
111Asthma_Homo sapiens_hsa053100.08426588
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07990534
113Serotonergic synapse_Homo sapiens_hsa047260.05712157
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05019071
115Autoimmune thyroid disease_Homo sapiens_hsa053200.03468544
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.03366109
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02201315
118Systemic lupus erythematosus_Homo sapiens_hsa053220.01610632
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.00661443
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.00609215
121Glycerolipid metabolism_Homo sapiens_hsa005610.00162783
122Retinol metabolism_Homo sapiens_hsa00830-0.0210537
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0146965

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