NDUFB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.99069335
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.99069335
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.43329801
4* respiratory electron transport chain (GO:0022904)8.81335109
5* electron transport chain (GO:0022900)8.59685481
6oxidative phosphorylation (GO:0006119)5.88748823
7chaperone-mediated protein transport (GO:0072321)5.67926464
8protein complex biogenesis (GO:0070271)5.63715566
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.61667469
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.57945020
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.57945020
12NADH dehydrogenase complex assembly (GO:0010257)5.57945020
13ATP biosynthetic process (GO:0006754)5.51843727
14hydrogen ion transmembrane transport (GO:1902600)5.21804988
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.20903143
16mitochondrial respiratory chain complex assembly (GO:0033108)5.20568857
17purine nucleoside triphosphate biosynthetic process (GO:0009145)5.14792397
18inner mitochondrial membrane organization (GO:0007007)5.04677683
19protein neddylation (GO:0045116)4.66749375
20ribosomal small subunit biogenesis (GO:0042274)4.64079668
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.60397419
22proton transport (GO:0015992)4.55515634
23regulation of mitochondrial translation (GO:0070129)4.50188420
24hydrogen transport (GO:0006818)4.47161860
25viral transcription (GO:0019083)4.22049919
26aerobic respiration (GO:0009060)4.17879226
27regulation of oxidative phosphorylation (GO:0002082)4.13646701
28proteasome assembly (GO:0043248)4.12679176
29GTP biosynthetic process (GO:0006183)4.12611100
30translational termination (GO:0006415)4.11134780
31nucleoside triphosphate biosynthetic process (GO:0009142)4.03637281
32protein targeting to mitochondrion (GO:0006626)4.00226672
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97089823
34establishment of protein localization to mitochondrion (GO:0072655)3.96095391
35respiratory chain complex IV assembly (GO:0008535)3.95475152
36ribosomal large subunit biogenesis (GO:0042273)3.94490562
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.92074844
38tricarboxylic acid cycle (GO:0006099)3.87685279
39protein localization to mitochondrion (GO:0070585)3.87568250
40mitochondrial transport (GO:0006839)3.85301934
41cotranslational protein targeting to membrane (GO:0006613)3.82135690
42chromatin remodeling at centromere (GO:0031055)3.78036538
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77695500
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76355398
45cytochrome complex assembly (GO:0017004)3.75522614
46protein targeting to ER (GO:0045047)3.75166001
47quinone biosynthetic process (GO:1901663)3.73550591
48ubiquinone biosynthetic process (GO:0006744)3.73550591
49CENP-A containing nucleosome assembly (GO:0034080)3.72146862
50ribosomal small subunit assembly (GO:0000028)3.71219885
51regulation of cellular respiration (GO:0043457)3.69105918
52protein localization to endoplasmic reticulum (GO:0070972)3.64395805
53water-soluble vitamin biosynthetic process (GO:0042364)3.59926322
54translational elongation (GO:0006414)3.59859636
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56578035
56DNA deamination (GO:0045006)3.56478163
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54025841
58rRNA modification (GO:0000154)3.49622405
59purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.49161478
60purine nucleoside monophosphate biosynthetic process (GO:0009127)3.49161478
61regulation of cellular amino acid metabolic process (GO:0006521)3.48995246
62cellular respiration (GO:0045333)3.45858843
63translation (GO:0006412)3.44436259
64UTP biosynthetic process (GO:0006228)3.43987142
65ubiquinone metabolic process (GO:0006743)3.42031606
66spliceosomal snRNP assembly (GO:0000387)3.38557115
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36744936
68cullin deneddylation (GO:0010388)3.36240000
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35769488
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35769488
71establishment of integrated proviral latency (GO:0075713)3.34128676
72maturation of SSU-rRNA (GO:0030490)3.34090038
73guanosine-containing compound biosynthetic process (GO:1901070)3.33698999
74dopamine transport (GO:0015872)3.33690489
75cellular protein complex disassembly (GO:0043624)3.33210090
76intracellular protein transmembrane import (GO:0044743)3.32295357
77viral life cycle (GO:0019058)3.30126172
78DNA damage response, detection of DNA damage (GO:0042769)3.26932897
79ATP hydrolysis coupled proton transport (GO:0015991)3.26815275
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26815275
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25688146
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21835195
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.21835195
84pseudouridine synthesis (GO:0001522)3.21554469
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.20301800
86* generation of precursor metabolites and energy (GO:0006091)3.18807052
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17478577
88sequestering of actin monomers (GO:0042989)3.15810411
89DNA double-strand break processing (GO:0000729)3.13798643
90purine ribonucleoside biosynthetic process (GO:0046129)3.13406429
91purine nucleoside biosynthetic process (GO:0042451)3.13406429
92regulation of coenzyme metabolic process (GO:0051196)3.13320852
93regulation of cofactor metabolic process (GO:0051193)3.13320852
94cellular component biogenesis (GO:0044085)3.11659987
95positive regulation of ligase activity (GO:0051351)3.10943440
96positive regulation of mitochondrial fission (GO:0090141)3.10856925
97UTP metabolic process (GO:0046051)3.10649982
98protein deneddylation (GO:0000338)3.07103927
99negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.07019597
100platelet dense granule organization (GO:0060155)3.06851113
101NADH metabolic process (GO:0006734)3.06406152
102histone exchange (GO:0043486)3.06149952
103termination of RNA polymerase III transcription (GO:0006386)3.04857845
104transcription elongation from RNA polymerase III promoter (GO:0006385)3.04857845
105DNA replication checkpoint (GO:0000076)2.99917981
106protein-cofactor linkage (GO:0018065)2.94861408
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94628278
108translational initiation (GO:0006413)2.92846914
109negative regulation of ligase activity (GO:0051352)2.89916219
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89916219
111CTP metabolic process (GO:0046036)2.89113780
112CTP biosynthetic process (GO:0006241)2.89113780
113peptidyl-histidine modification (GO:0018202)2.88919674
114histone mRNA metabolic process (GO:0008334)2.88904291
115regulation of acyl-CoA biosynthetic process (GO:0050812)2.88872444
116ribonucleoside monophosphate biosynthetic process (GO:0009156)2.87080711
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86934543
118regulation of ubiquitin-protein transferase activity (GO:0051438)2.86809333
1197-methylguanosine mRNA capping (GO:0006370)2.85703314
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83720401
121establishment of viral latency (GO:0019043)2.82217325
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81868619
123regulation of cellular amine metabolic process (GO:0033238)2.80381327
124succinate metabolic process (GO:0006105)2.79627337
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79175970
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78909937
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78909937
128aldehyde catabolic process (GO:0046185)2.77495987
129nucleoside diphosphate phosphorylation (GO:0006165)2.77271756
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74819369
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74819369
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.1485490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12322467
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.34293853
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.25330995
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97860117
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84326909
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.71637613
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.38042132
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32015891
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.22512741
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.21078127
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.12526936
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04906323
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00318883
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98014413
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94397908
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93303508
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.89522298
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57625484
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50222352
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41285195
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.40734122
22DCP1A_22483619_ChIP-Seq_HELA_Human2.33728087
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.24406191
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16218321
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12967737
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07462606
27* VDR_23849224_ChIP-Seq_CD4+_Human1.97924610
28VDR_22108803_ChIP-Seq_LS180_Human1.95920867
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95386334
30E2F7_22180533_ChIP-Seq_HELA_Human1.88843902
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87664402
32ZNF274_21170338_ChIP-Seq_K562_Hela1.86755093
33* XRN2_22483619_ChIP-Seq_HELA_Human1.68693247
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65363578
35TTF2_22483619_ChIP-Seq_HELA_Human1.65077533
36EWS_26573619_Chip-Seq_HEK293_Human1.65022668
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64833082
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63521116
39ELK1_19687146_ChIP-ChIP_HELA_Human1.63104145
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62690153
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.52032012
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.45412014
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44543778
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43021656
45IGF1R_20145208_ChIP-Seq_DFB_Human1.41526713
46GABP_19822575_ChIP-Seq_HepG2_Human1.40949228
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39845121
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39761158
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36211285
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31984230
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29516489
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28622400
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28282634
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26080624
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25610069
56MYC_18940864_ChIP-ChIP_HL60_Human1.23905398
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22595812
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22591911
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19501946
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19448914
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19292443
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18556442
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15523552
64TP53_22573176_ChIP-Seq_HFKS_Human1.14431223
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13341999
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12047841
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.12003396
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08886346
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08086304
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.08005525
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07752558
72P300_19829295_ChIP-Seq_ESCs_Human1.05544078
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03926607
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02280948
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02096443
76HTT_18923047_ChIP-ChIP_STHdh_Human1.01232632
77EZH2_22144423_ChIP-Seq_EOC_Human0.99884450
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99763774
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97546302
80E2F1_21310950_ChIP-Seq_MCF-7_Human0.96204691
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93068387
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91513738
83BP1_19119308_ChIP-ChIP_Hs578T_Human0.90754851
84IRF1_19129219_ChIP-ChIP_H3396_Human0.90431051
85FUS_26573619_Chip-Seq_HEK293_Human0.89574903
86ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89413586
87TAF15_26573619_Chip-Seq_HEK293_Human0.89156696
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88842617
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.88842617
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87497582
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85892609
92* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85442976
93NANOG_19829295_ChIP-Seq_ESCs_Human0.84896168
94SOX2_19829295_ChIP-Seq_ESCs_Human0.84896168
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84869975
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.84844788
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84843041
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83438604
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81916646
100AR_20517297_ChIP-Seq_VCAP_Human0.81477466
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81269222
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80710484
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.79531553
104KDM5A_27292631_Chip-Seq_BREAST_Human0.79090112
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78036029
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77740679
107ERG_20517297_ChIP-Seq_VCAP_Human0.77693462
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77689494
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77308749
110PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76693118
111* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76493150
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76430581
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76401579
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76048383
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.75884621
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74600672
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.73500161
118REST_19997604_ChIP-ChIP_NEURONS_Mouse0.73390685
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73129629
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73102694
121STAT1_20625510_ChIP-Seq_HELA_Human0.72449130
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71988707
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71621935
124NANOG_20526341_ChIP-Seq_ESCs_Human0.71584589
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70852513
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70506016
127* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70430749
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69540327
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68831988
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67344831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.20371056
2MP0006036_abnormal_mitochondrial_physio3.76289150
3MP0002837_dystrophic_cardiac_calcinosis3.69398808
4MP0009379_abnormal_foot_pigmentation3.68825867
5MP0001529_abnormal_vocalization3.63497159
6MP0006276_abnormal_autonomic_nervous2.96715790
7MP0008058_abnormal_DNA_repair2.92336839
8MP0006035_abnormal_mitochondrial_morpho2.83969579
9MP0003806_abnormal_nucleotide_metabolis2.72117807
10MP0003880_abnormal_central_pattern2.67458989
11MP0001905_abnormal_dopamine_level2.59950835
12MP0006292_abnormal_olfactory_placode2.29636072
13MP0000749_muscle_degeneration2.25659557
14MP0003186_abnormal_redox_activity2.24151522
15MP0002822_catalepsy2.22983331
16MP0004215_abnormal_myocardial_fiber2.16105355
17MP0003011_delayed_dark_adaptation2.12534038
18MP0008877_abnormal_DNA_methylation2.10410309
19MP0010094_abnormal_chromosome_stability2.04405734
20MP0002332_abnormal_exercise_endurance2.03532476
21MP0004957_abnormal_blastocyst_morpholog2.01343517
22MP0000751_myopathy2.00641549
23MP0003693_abnormal_embryo_hatching1.96956104
24MP0002736_abnormal_nociception_after1.95736190
25MP0004142_abnormal_muscle_tone1.95378389
26MP0005330_cardiomyopathy1.90675170
27MP0003195_calcinosis1.89159487
28MP0004036_abnormal_muscle_relaxation1.88016115
29MP0002938_white_spotting1.82868772
30MP0003786_premature_aging1.76218749
31MP0002735_abnormal_chemical_nociception1.72225737
32MP0001968_abnormal_touch/_nociception1.69143997
33MP0004147_increased_porphyrin_level1.65797474
34MP0004043_abnormal_pH_regulation1.61656259
35MP0005253_abnormal_eye_physiology1.56563621
36MP0008932_abnormal_embryonic_tissue1.51260880
37MP0004145_abnormal_muscle_electrophysio1.50610076
38MP0008995_early_reproductive_senescence1.48803907
39MP0001440_abnormal_grooming_behavior1.46782947
40MP0004084_abnormal_cardiac_muscle1.45240279
41MP0002638_abnormal_pupillary_reflex1.44861036
42MP0003137_abnormal_impulse_conducting1.44717843
43MP0005084_abnormal_gallbladder_morpholo1.44533879
44MP0005266_abnormal_metabolism1.43780826
45MP0001727_abnormal_embryo_implantation1.43393815
46MP0005551_abnormal_eye_electrophysiolog1.43140729
47MP0005535_abnormal_body_temperature1.42897910
48MP0003121_genomic_imprinting1.42764764
49MP0010386_abnormal_urinary_bladder1.42519185
50MP0001188_hyperpigmentation1.40665935
51MP0000372_irregular_coat_pigmentation1.39915873
52MP0004484_altered_response_of1.37582253
53MP0003077_abnormal_cell_cycle1.36525648
54MP0002272_abnormal_nervous_system1.35860218
55MP0002972_abnormal_cardiac_muscle1.35845047
56MP0009697_abnormal_copulation1.35813845
57MP0005332_abnormal_amino_acid1.32146729
58MP0000631_abnormal_neuroendocrine_gland1.30250691
59MP0009046_muscle_twitch1.29137835
60MP0002734_abnormal_mechanical_nocicepti1.29131641
61MP0002277_abnormal_respiratory_mucosa1.29074038
62MP0001293_anophthalmia1.28270517
63MP0009745_abnormal_behavioral_response1.27851059
64MP0005386_behavior/neurological_phenoty1.27271132
65MP0004924_abnormal_behavior1.27271132
66MP0003123_paternal_imprinting1.25040378
67MP0001970_abnormal_pain_threshold1.24982208
68MP0001984_abnormal_olfaction1.23317206
69MP0004133_heterotaxia1.22449292
70MP0003111_abnormal_nucleus_morphology1.21850699
71MP0005646_abnormal_pituitary_gland1.20506731
72MP0005360_urolithiasis1.18454069
73MP0005620_abnormal_muscle_contractility1.17859255
74MP0002160_abnormal_reproductive_system1.16725786
75MP0002733_abnormal_thermal_nociception1.16376002
76MP0005636_abnormal_mineral_homeostasis1.16017576
77MP0008007_abnormal_cellular_replicative1.14856238
78MP0002653_abnormal_ependyma_morphology1.14666626
79MP0002106_abnormal_muscle_physiology1.13614263
80MP0008775_abnormal_heart_ventricle1.12293262
81MP0002163_abnormal_gland_morphology1.11654094
82MP0002064_seizures1.10452965
83MP0008872_abnormal_physiological_respon1.08283833
84MP0000750_abnormal_muscle_regeneration1.07689010
85MP0005451_abnormal_body_composition1.07509756
86MP0002876_abnormal_thyroid_physiology1.06768775
87MP0002090_abnormal_vision1.06140349
88MP0002210_abnormal_sex_determination1.05617785
89MP0003718_maternal_effect1.05055333
90MP0004130_abnormal_muscle_cell1.04577065
91MP0003787_abnormal_imprinting1.04336962
92MP0008875_abnormal_xenobiotic_pharmacok1.03694396
93MP0003567_abnormal_fetal_cardiomyocyte1.03030663
94MP0005389_reproductive_system_phenotype1.02809215
95MP0003941_abnormal_skin_development1.01935479
96MP0000538_abnormal_urinary_bladder1.01559277
97MP0003122_maternal_imprinting1.00206839
98MP0003136_yellow_coat_color0.98640586
99MP0002572_abnormal_emotion/affect_behav0.97257487
100MP0000013_abnormal_adipose_tissue0.96811419
101MP0003221_abnormal_cardiomyocyte_apopto0.96160102
102MP0001929_abnormal_gametogenesis0.94445451
103MP0001986_abnormal_taste_sensitivity0.93567393
104MP0008789_abnormal_olfactory_epithelium0.93450379
105MP0003315_abnormal_perineum_morphology0.92030062
106MP0001764_abnormal_homeostasis0.91697413
107MP0002067_abnormal_sensory_capabilities0.91656814
108MP0000230_abnormal_systemic_arterial0.91301828
109MP0005376_homeostasis/metabolism_phenot0.90353276
110MP0002139_abnormal_hepatobiliary_system0.89456010
111MP0005410_abnormal_fertilization0.89264146
112MP0000358_abnormal_cell_content/0.89253934
113MP0005385_cardiovascular_system_phenoty0.89081521
114MP0001544_abnormal_cardiovascular_syste0.89081521
115MP0006072_abnormal_retinal_apoptosis0.87798635
116MP0005083_abnormal_biliary_tract0.87609709
117MP0001485_abnormal_pinna_reflex0.87506653
118MP0005085_abnormal_gallbladder_physiolo0.86794985
119MP0005369_muscle_phenotype0.86612476
120MP0001664_abnormal_digestion0.86134830
121MP0004270_analgesia0.85963633
122MP0005171_absent_coat_pigmentation0.85814238
123MP0001919_abnormal_reproductive_system0.85261203
124MP0000653_abnormal_sex_gland0.85206335
125MP0001501_abnormal_sleep_pattern0.85197990
126MP0005499_abnormal_olfactory_system0.83238193
127MP0005394_taste/olfaction_phenotype0.83238193
128MP0005423_abnormal_somatic_nervous0.82988104
129MP0003635_abnormal_synaptic_transmissio0.82564877
130MP0004085_abnormal_heartbeat0.82422939
131MP0001145_abnormal_male_reproductive0.82398854
132MP0000747_muscle_weakness0.82327739
133MP0004742_abnormal_vestibular_system0.81880826
134MP0005075_abnormal_melanosome_morpholog0.81695792
135MP0002269_muscular_atrophy0.80069598
136MP0005584_abnormal_enzyme/coenzyme_acti0.79706796
137MP0003698_abnormal_male_reproductive0.77265437
138MP0005379_endocrine/exocrine_gland_phen0.77147823
139MP0002102_abnormal_ear_morphology0.77141599
140MP0005367_renal/urinary_system_phenotyp0.76803086
141MP0000516_abnormal_urinary_system0.76803086
142MP0001486_abnormal_startle_reflex0.76463050
143MP0000049_abnormal_middle_ear0.76168674
144MP0005195_abnormal_posterior_eye0.75803740
145MP0000026_abnormal_inner_ear0.74412783
146MP0002751_abnormal_autonomic_nervous0.74201807
147MP0002184_abnormal_innervation0.72372109
148MP0005645_abnormal_hypothalamus_physiol0.72265799

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)8.11502480
2Abnormal mitochondria in muscle tissue (HP:0008316)7.51159571
3Acute encephalopathy (HP:0006846)6.91250250
4Mitochondrial inheritance (HP:0001427)6.90880551
5Progressive macrocephaly (HP:0004481)6.78350723
6Increased CSF lactate (HP:0002490)6.08493553
7Hepatocellular necrosis (HP:0001404)5.82351022
8Hepatic necrosis (HP:0002605)5.55633556
9Cerebral edema (HP:0002181)5.38850861
10Increased hepatocellular lipid droplets (HP:0006565)5.07260965
11Lipid accumulation in hepatocytes (HP:0006561)4.80689183
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.65874821
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.60075664
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.60075664
15Exercise intolerance (HP:0003546)4.44567852
16Lactic acidosis (HP:0003128)4.42898874
17Increased intramyocellular lipid droplets (HP:0012240)4.34321866
18Respiratory failure (HP:0002878)4.34214130
19Optic disc pallor (HP:0000543)4.24692000
20Increased serum pyruvate (HP:0003542)4.21430554
21Abnormality of glycolysis (HP:0004366)4.21430554
22Renal Fanconi syndrome (HP:0001994)4.19225992
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.05375459
24Increased muscle lipid content (HP:0009058)3.98497145
25Increased serum lactate (HP:0002151)3.96333769
26Leukodystrophy (HP:0002415)3.88387237
273-Methylglutaconic aciduria (HP:0003535)3.51802264
28Abnormality of cells of the erythroid lineage (HP:0012130)3.40739806
29Exertional dyspnea (HP:0002875)3.22321043
30Microvesicular hepatic steatosis (HP:0001414)3.10250439
31Pheochromocytoma (HP:0002666)3.02002013
32Neuroendocrine neoplasm (HP:0100634)3.01412050
33Abnormal number of erythroid precursors (HP:0012131)3.00587203
34Respiratory difficulties (HP:0002880)3.00465959
35Lethargy (HP:0001254)3.00045793
36Glycosuria (HP:0003076)2.84587664
37Abnormality of urine glucose concentration (HP:0011016)2.84587664
38Dicarboxylic aciduria (HP:0003215)2.76322144
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76322144
40Abnormality of renal resorption (HP:0011038)2.74646393
41X-linked dominant inheritance (HP:0001423)2.72737195
42CNS demyelination (HP:0007305)2.62516901
43Hyperphosphaturia (HP:0003109)2.62360006
44Congenital, generalized hypertrichosis (HP:0004540)2.62123692
45Palpitations (HP:0001962)2.54742320
46Pancreatic cysts (HP:0001737)2.49864170
47Type I transferrin isoform profile (HP:0003642)2.48484964
48Abnormality of midbrain morphology (HP:0002418)2.44036066
49Molar tooth sign on MRI (HP:0002419)2.44036066
50Pancreatic fibrosis (HP:0100732)2.42168096
51Hyperglycinemia (HP:0002154)2.39732437
52Emotional lability (HP:0000712)2.38230965
53Methylmalonic aciduria (HP:0012120)2.37654585
54Macrocytic anemia (HP:0001972)2.36750578
55Medial flaring of the eyebrow (HP:0010747)2.36222664
56Aplastic anemia (HP:0001915)2.31134830
57Abnormality of the anterior horn cell (HP:0006802)2.30373628
58Degeneration of anterior horn cells (HP:0002398)2.30373628
59True hermaphroditism (HP:0010459)2.27080033
60Conjunctival hamartoma (HP:0100780)2.26446335
61Vomiting (HP:0002013)2.25156072
62Hyperalaninemia (HP:0003348)2.23857272
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23857272
64Abnormality of alanine metabolism (HP:0010916)2.23857272
65Myokymia (HP:0002411)2.23114214
66Colon cancer (HP:0003003)2.20522741
67Ragged-red muscle fibers (HP:0003200)2.18999222
68Generalized aminoaciduria (HP:0002909)2.14021688
69Abnormal urine phosphate concentration (HP:0012599)2.12359065
70Abnormality of the labia minora (HP:0012880)2.10917888
71Methylmalonic acidemia (HP:0002912)2.06246978
72Progressive external ophthalmoplegia (HP:0000590)2.05150121
73Abnormal protein glycosylation (HP:0012346)2.02193175
74Abnormal glycosylation (HP:0012345)2.02193175
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02193175
76Abnormal protein N-linked glycosylation (HP:0012347)2.02193175
77Gliosis (HP:0002171)2.00856678
78Abnormality of placental membranes (HP:0011409)2.00159406
79Amniotic constriction ring (HP:0009775)2.00159406
80Esophageal neoplasm (HP:0100751)1.99705544
81Neoplasm of head and neck (HP:0012288)1.99705544
82Nephronophthisis (HP:0000090)1.98365232
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96831610
84Rhabdomyolysis (HP:0003201)1.96496525
85Abnormality of methionine metabolism (HP:0010901)1.95909906
86Sudden death (HP:0001699)1.95875887
87Congenital primary aphakia (HP:0007707)1.93885952
88Hypothermia (HP:0002045)1.93106158
89Gait imbalance (HP:0002141)1.92368644
90Muscle hypertrophy of the lower extremities (HP:0008968)1.88002489
91Sclerocornea (HP:0000647)1.87352862
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86616570
93Nausea (HP:0002018)1.85485220
94Septo-optic dysplasia (HP:0100842)1.85428592
95Calf muscle hypertrophy (HP:0008981)1.84926622
96Blindness (HP:0000618)1.84168114
97Abnormality of fatty-acid metabolism (HP:0004359)1.83734416
98Abnormal pupillary function (HP:0007686)1.82046777
99Pallor (HP:0000980)1.81481433
100Reticulocytopenia (HP:0001896)1.79854499
101Meckel diverticulum (HP:0002245)1.79688426
102Limb dystonia (HP:0002451)1.78354545
103Nephrogenic diabetes insipidus (HP:0009806)1.77108029
104Reduced antithrombin III activity (HP:0001976)1.76882603
105Poor suck (HP:0002033)1.76068348
106Aplasia/hypoplasia of the uterus (HP:0008684)1.76010514
107Myoglobinuria (HP:0002913)1.75089518
108Renal tubular dysfunction (HP:0000124)1.75085781
109Pancytopenia (HP:0001876)1.72819073
110Abnormality of the ileum (HP:0001549)1.72324264
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.72225963
112Proximal tubulopathy (HP:0000114)1.71850164
113Myotonia (HP:0002486)1.71622506
114Abnormality of vitamin B metabolism (HP:0004340)1.70997400
115Oral leukoplakia (HP:0002745)1.68526768
116Metabolic acidosis (HP:0001942)1.67080701
117Abnormality of serine family amino acid metabolism (HP:0010894)1.64408517
118Abnormality of glycine metabolism (HP:0010895)1.64408517
119Muscle stiffness (HP:0003552)1.61429197
120Megaloblastic anemia (HP:0001889)1.60889688
121Hyperglycinuria (HP:0003108)1.60208157
122Renal cortical cysts (HP:0000803)1.60057959
123Abnormal hemoglobin (HP:0011902)1.60028595
124Cerebral hemorrhage (HP:0001342)1.57023232
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.53399694
126Hypokinesia (HP:0002375)1.53018033
127Neoplasm of the adrenal gland (HP:0100631)1.47103836
128Neoplasm of the peripheral nervous system (HP:0100007)1.46270079
129Hypoglycemic coma (HP:0001325)1.45369232
130Progressive muscle weakness (HP:0003323)1.44260120
131Congenital ichthyosiform erythroderma (HP:0007431)1.44210543
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.42479480
133Parakeratosis (HP:0001036)1.41056792
134Hypoplastic left heart (HP:0004383)1.40946100
135Abnormality of serum amino acid levels (HP:0003112)1.39770270
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.39592604
137Brushfield spots (HP:0001088)1.39156296
138Athetosis (HP:0002305)1.38432749
139Delayed gross motor development (HP:0002194)1.38240085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.04858514
2VRK23.95467249
3MAP3K123.46828018
4ARAF3.38974066
5NME13.18595713
6STK162.76635809
7EIF2AK12.76542282
8MYLK2.67816712
9PBK2.35839088
10BUB12.35614903
11BCKDK2.30391903
12CDC72.23968272
13MAP4K22.12044969
14OBSCN1.94724618
15NUAK11.94157293
16LIMK11.93064298
17TRIM281.83287941
18EIF2AK31.78895218
19PIM21.78438048
20TLK11.73354993
21STK391.70995943
22BRAF1.68806616
23MUSK1.68059656
24GRK51.63759890
25VRK11.63290324
26PLK31.61757090
27WNK41.54353389
28GRK71.53479965
29MST41.53224189
30CASK1.50928055
31PINK11.40981333
32CSNK1G21.32006734
33INSRR1.28684318
34CSNK1G11.27448120
35ABL21.26923772
36GRK11.25309721
37PLK41.19350607
38TESK21.15779635
39OXSR11.15014753
40PDK41.13556894
41PDK31.13556894
42ADRBK21.12545908
43DAPK31.10101460
44MKNK11.10067560
45MST1R1.09568570
46MAP2K71.09101464
47TTK1.06511478
48CAMK2D1.04182073
49BCR1.04084890
50DYRK21.03991671
51MAP3K111.03438931
52STK38L1.03149891
53TSSK61.01894645
54TAF11.01131713
55BRSK21.00659358
56CSNK1A1L1.00176740
57ERBB30.97357684
58PDK20.97316088
59BMPR1B0.96444327
60FRK0.95549110
61BMPR20.92889174
62PLK20.92554801
63WEE10.90087771
64MAPKAPK50.87327345
65TESK10.85930196
66STK240.85537316
67ILK0.85054549
68PNCK0.84112117
69SRPK10.83477885
70CAMK2B0.82831351
71ADRBK10.81306335
72CDK190.79952601
73CAMK2G0.79486431
74CAMK2A0.78239305
75DYRK30.76743274
76AURKB0.76634894
77AURKA0.74951189
78PIK3CA0.73782346
79CSNK1G30.70241355
80MINK10.69181905
81LMTK20.68490199
82BRSK10.68232045
83PHKG10.67706606
84PHKG20.67706606
85MOS0.67078091
86ZAK0.64901955
87CDK80.64738529
88TNIK0.63996652
89WNK30.62529105
90CHEK20.58565073
91MARK10.56502532
92ATR0.56450490
93MAPK130.53608625
94ROCK20.53188186
95CSNK2A10.51876186
96PRKCE0.51726094
97PRKACA0.50850982
98MAP3K40.50524422
99PASK0.50428296
100RPS6KA40.49285898
101CDK140.47751976
102RPS6KA50.47508960
103EIF2AK20.47362391
104PAK10.46901986
105MAP2K40.44848152
106EPHA40.44221596
107PAK30.44006640
108ACVR1B0.43624388
109CSNK2A20.40582789
110DAPK10.40544193
111PRKCG0.40495747
112RPS6KB20.39785968
113CDK30.39365613
114CSNK1A10.39293798
115ERBB40.38319372
116KDR0.37781356
117UHMK10.37207528
118CDK180.36870129
119NEK10.36154250
120STK40.34190302
121CDK150.34059826
122CCNB10.33511162
123MAP2K10.32931738
124CDK11A0.32318068
125RAF10.32139059
126RIPK40.32134527
127PTK2B0.31987944
128PKN10.30470919
129PLK10.29878823
130MKNK20.29744096

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.52149391
2Parkinsons disease_Homo sapiens_hsa050125.79075280
3Alzheimers disease_Homo sapiens_hsa050104.25246214
4Huntingtons disease_Homo sapiens_hsa050164.07938049
5Ribosome_Homo sapiens_hsa030103.78597905
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.63035669
7Proteasome_Homo sapiens_hsa030503.29288474
8Cardiac muscle contraction_Homo sapiens_hsa042603.06607866
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.75700650
10RNA polymerase_Homo sapiens_hsa030202.12713440
11Protein export_Homo sapiens_hsa030602.03591426
12Sulfur metabolism_Homo sapiens_hsa009202.00693093
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80543349
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74272388
15Propanoate metabolism_Homo sapiens_hsa006401.72170196
16Fatty acid elongation_Homo sapiens_hsa000621.57224587
17Pyruvate metabolism_Homo sapiens_hsa006201.55823242
18Fanconi anemia pathway_Homo sapiens_hsa034601.48903266
19Collecting duct acid secretion_Homo sapiens_hsa049661.41629150
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38642254
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38172968
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34718423
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31929900
24Carbon metabolism_Homo sapiens_hsa012001.30434254
25Pyrimidine metabolism_Homo sapiens_hsa002401.23801433
26One carbon pool by folate_Homo sapiens_hsa006701.23618006
27Non-homologous end-joining_Homo sapiens_hsa034501.17663475
28Butanoate metabolism_Homo sapiens_hsa006501.02932562
29* Metabolic pathways_Homo sapiens_hsa011000.98653386
30Glutathione metabolism_Homo sapiens_hsa004800.90907994
31Peroxisome_Homo sapiens_hsa041460.90209247
32Sulfur relay system_Homo sapiens_hsa041220.88160603
33Fatty acid degradation_Homo sapiens_hsa000710.81338277
34Vibrio cholerae infection_Homo sapiens_hsa051100.81167901
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80533876
36Folate biosynthesis_Homo sapiens_hsa007900.74064894
37Purine metabolism_Homo sapiens_hsa002300.71778861
38Tyrosine metabolism_Homo sapiens_hsa003500.71767660
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71368572
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.70816961
41Phenylalanine metabolism_Homo sapiens_hsa003600.67131631
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66709661
43Homologous recombination_Homo sapiens_hsa034400.65792702
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65500222
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.65016194
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64925403
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64461210
48Nucleotide excision repair_Homo sapiens_hsa034200.64452631
49Selenocompound metabolism_Homo sapiens_hsa004500.64429625
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64264710
51Vitamin B6 metabolism_Homo sapiens_hsa007500.63731400
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58745414
53Arachidonic acid metabolism_Homo sapiens_hsa005900.58479365
54Fatty acid metabolism_Homo sapiens_hsa012120.58449545
55Cell cycle_Homo sapiens_hsa041100.57846842
56DNA replication_Homo sapiens_hsa030300.56732403
57Biosynthesis of amino acids_Homo sapiens_hsa012300.56716052
58Nitrogen metabolism_Homo sapiens_hsa009100.55878518
59Chemical carcinogenesis_Homo sapiens_hsa052040.54755393
60Mismatch repair_Homo sapiens_hsa034300.53400955
61Synaptic vesicle cycle_Homo sapiens_hsa047210.50122779
62Linoleic acid metabolism_Homo sapiens_hsa005910.49450630
63Fructose and mannose metabolism_Homo sapiens_hsa000510.49147611
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48757111
65Arginine and proline metabolism_Homo sapiens_hsa003300.48392124
66Steroid biosynthesis_Homo sapiens_hsa001000.47783242
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45842423
68Systemic lupus erythematosus_Homo sapiens_hsa053220.44938077
69Pentose phosphate pathway_Homo sapiens_hsa000300.44667272
70Spliceosome_Homo sapiens_hsa030400.44363001
71beta-Alanine metabolism_Homo sapiens_hsa004100.43089354
72Oocyte meiosis_Homo sapiens_hsa041140.42789183
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42751419
74Caffeine metabolism_Homo sapiens_hsa002320.42347318
75Nicotine addiction_Homo sapiens_hsa050330.42210465
76Ether lipid metabolism_Homo sapiens_hsa005650.40548254
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39444637
78Histidine metabolism_Homo sapiens_hsa003400.38192358
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38161119
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37595168
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.37307591
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36821064
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.36606773
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35869028
85Rheumatoid arthritis_Homo sapiens_hsa053230.34978217
86Serotonergic synapse_Homo sapiens_hsa047260.34964952
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34898236
88PPAR signaling pathway_Homo sapiens_hsa033200.34823854
89RNA degradation_Homo sapiens_hsa030180.33696276
90Regulation of autophagy_Homo sapiens_hsa041400.31597936
91Basal transcription factors_Homo sapiens_hsa030220.31527200
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30319633
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30289336
94N-Glycan biosynthesis_Homo sapiens_hsa005100.29684490
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28773611
96Alcoholism_Homo sapiens_hsa050340.27847812
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27061383
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25895326
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25376009
100Vitamin digestion and absorption_Homo sapiens_hsa049770.24364628
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24198318
102Tryptophan metabolism_Homo sapiens_hsa003800.23772485
103Taste transduction_Homo sapiens_hsa047420.22411634
104Retinol metabolism_Homo sapiens_hsa008300.22377685
105mRNA surveillance pathway_Homo sapiens_hsa030150.21383172
106Galactose metabolism_Homo sapiens_hsa000520.18872258
107Phagosome_Homo sapiens_hsa041450.17114990
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.16838538
109Starch and sucrose metabolism_Homo sapiens_hsa005000.16488194
110GABAergic synapse_Homo sapiens_hsa047270.15717726
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15119206
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.15015863
113Fat digestion and absorption_Homo sapiens_hsa049750.14672399
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14515846
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11793708
116Phototransduction_Homo sapiens_hsa047440.10198381
117Base excision repair_Homo sapiens_hsa034100.09561207
118RNA transport_Homo sapiens_hsa030130.08211080

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