NDUFB4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021106.59553674
2mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)6.59553674
3substrate-independent telencephalic tangential migration (GO:0021826)5.54505364
4substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.54505364
5resolution of meiotic recombination intermediates (GO:0000712)5.38216623
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.18877843
7axon extension involved in axon guidance (GO:0048846)5.18877843
8protein polyglutamylation (GO:0018095)4.95251894
9positive regulation of male gonad development (GO:2000020)4.91921770
10axonal fasciculation (GO:0007413)4.87062473
11retinal ganglion cell axon guidance (GO:0031290)4.85749867
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.63033836
13respiratory chain complex IV assembly (GO:0008535)4.54310945
14somite development (GO:0061053)4.39107566
15pyrimidine nucleobase catabolic process (GO:0006208)4.29985167
16negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.29004708
17sequestering of actin monomers (GO:0042989)4.20913556
18response to pheromone (GO:0019236)4.15386168
19cardiac left ventricle morphogenesis (GO:0003214)4.08250687
20meiotic chromosome segregation (GO:0045132)4.06258758
21peripheral nervous system neuron development (GO:0048935)3.93723630
22positive regulation of mitochondrial membrane permeability (GO:0035794)3.93453302
23DNA damage response, detection of DNA damage (GO:0042769)3.89735868
24platelet dense granule organization (GO:0060155)3.88598285
25viral transcription (GO:0019083)3.85117888
26intraciliary transport (GO:0042073)3.84292644
27translational termination (GO:0006415)3.79069562
28regulation of male gonad development (GO:2000018)3.74470633
29epithelial cilium movement (GO:0003351)3.74187128
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.73539501
31positive regulation of mitochondrial fission (GO:0090141)3.71519174
32behavioral response to nicotine (GO:0035095)3.57676632
33nucleobase catabolic process (GO:0046113)3.53891784
34positive regulation of vesicle fusion (GO:0031340)3.53269861
35ribosomal small subunit assembly (GO:0000028)3.52443685
36negative regulation of DNA-templated transcription, elongation (GO:0032785)3.51013215
37cytochrome complex assembly (GO:0017004)3.48091335
38cotranslational protein targeting to membrane (GO:0006613)3.39448045
39neurofilament cytoskeleton organization (GO:0060052)3.38895236
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37700304
41protein targeting to ER (GO:0045047)3.32384878
42neuron fate determination (GO:0048664)3.24006590
43neuron recognition (GO:0008038)3.23097025
44aldehyde catabolic process (GO:0046185)3.22326478
45nonmotile primary cilium assembly (GO:0035058)3.19819878
46regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.16059357
47protein complex biogenesis (GO:0070271)3.15378792
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14762437
49positive regulation of protein homooligomerization (GO:0032464)3.12845611
50protein localization to endoplasmic reticulum (GO:0070972)3.11961648
51response to folic acid (GO:0051593)3.11759346
52cilium organization (GO:0044782)3.11238846
53glycerol metabolic process (GO:0006071)3.10262530
54cilium assembly (GO:0042384)3.09438311
55regulation of penile erection (GO:0060405)3.09042632
56translational elongation (GO:0006414)3.08185525
57neuronal stem cell maintenance (GO:0097150)3.06034244
58detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.05201262
59proteasome assembly (GO:0043248)3.02231444
60anterograde synaptic vesicle transport (GO:0048490)3.01150764
61water-soluble vitamin biosynthetic process (GO:0042364)3.00803232
62kinetochore organization (GO:0051383)2.99239767
63chaperone-mediated protein transport (GO:0072321)2.98874329
64negative regulation of mast cell activation (GO:0033004)2.98195693
65forebrain neuron differentiation (GO:0021879)2.94706669
66spinal cord association neuron differentiation (GO:0021527)2.93160704
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91462348
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.91462348
69NADH dehydrogenase complex assembly (GO:0010257)2.91462348
70cellular protein complex disassembly (GO:0043624)2.86989452
71negative regulation of neurotransmitter transport (GO:0051589)2.85946877
72translesion synthesis (GO:0019985)2.82434584
73centriole replication (GO:0007099)2.80154454
74calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78583682
75myoblast migration (GO:0051451)2.78419207
76ribosomal small subunit biogenesis (GO:0042274)2.77095463
77rRNA catabolic process (GO:0016075)2.76258498
78mitochondrial respiratory chain complex assembly (GO:0033108)2.75296499
79negative regulation of axon guidance (GO:1902668)2.74422447
80regulation of synapse structural plasticity (GO:0051823)2.74203845
81cilium movement (GO:0003341)2.74078329
82positive regulation of gastrulation (GO:2000543)2.72697330
83postsynaptic membrane organization (GO:0001941)2.71078086
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70992500
85diacylglycerol metabolic process (GO:0046339)2.68495227
86negative regulation of oligodendrocyte differentiation (GO:0048715)2.68050580
87retinal rod cell development (GO:0046548)2.67905959
88regulation of glycogen (starch) synthase activity (GO:2000465)2.67613422
89phasic smooth muscle contraction (GO:0014821)2.66757067
90protein K48-linked ubiquitination (GO:0070936)2.66240986
91positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65773931
92anterograde axon cargo transport (GO:0008089)2.62410606
93regulation of mitochondrial fission (GO:0090140)2.61048621
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59733040
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.59733040
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59341715
97negative regulation of amino acid transport (GO:0051956)2.58256877
98DNA double-strand break processing (GO:0000729)2.57436971
99photoreceptor cell development (GO:0042461)2.57126891
100synapse assembly (GO:0007416)2.56089834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40541960
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.75519074
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13652304
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00168642
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85968133
6IRF1_19129219_ChIP-ChIP_H3396_Human2.64029993
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61331794
8VDR_22108803_ChIP-Seq_LS180_Human2.59633604
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57393460
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54557443
11EWS_26573619_Chip-Seq_HEK293_Human2.41820325
12RNF2_27304074_Chip-Seq_NSC_Mouse2.40791240
13ZNF274_21170338_ChIP-Seq_K562_Hela2.38106517
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35327915
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.34307323
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33378099
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31271142
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26563798
19TAF15_26573619_Chip-Seq_HEK293_Human2.20331610
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.07872474
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01047414
22FUS_26573619_Chip-Seq_HEK293_Human1.97020560
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95926038
24P300_19829295_ChIP-Seq_ESCs_Human1.93403505
25ELK1_19687146_ChIP-ChIP_HELA_Human1.84795042
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81106260
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.80822827
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.79599671
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78865257
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76549906
31IGF1R_20145208_ChIP-Seq_DFB_Human1.73071565
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72672705
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68153054
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.67350484
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64834590
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63539776
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59778496
38MYC_18940864_ChIP-ChIP_HL60_Human1.56767684
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54075479
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52649743
41GBX2_23144817_ChIP-Seq_PC3_Human1.44719829
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40193427
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39636919
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38540298
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37620843
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36767826
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.35881946
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.35480400
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34654825
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34550709
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33889457
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33510397
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33384706
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33311251
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33230056
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33035214
57TP53_18474530_ChIP-ChIP_U2OS_Human1.32096154
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.31952293
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30326075
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.29387194
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.24505425
62REST_21632747_ChIP-Seq_MESCs_Mouse1.24393385
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24123169
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23802451
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23596049
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.22925610
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21227423
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19180791
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19144086
70NANOG_19829295_ChIP-Seq_ESCs_Human1.19018132
71SOX2_19829295_ChIP-Seq_ESCs_Human1.19018132
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17439501
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16643365
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14849211
75STAT3_23295773_ChIP-Seq_U87_Human1.14320752
76TP53_22573176_ChIP-Seq_HFKS_Human1.14098954
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.13896879
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10821411
79AR_25329375_ChIP-Seq_VCAP_Human1.10525539
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.10498778
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09444088
82TCF4_22108803_ChIP-Seq_LS180_Human1.08119392
83VDR_23849224_ChIP-Seq_CD4+_Human1.08055464
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07981182
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.07784869
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04495646
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01281565
88JUN_21703547_ChIP-Seq_K562_Human1.01219848
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99962809
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99568897
91SMAD4_21799915_ChIP-Seq_A2780_Human0.99473332
92TCF4_23295773_ChIP-Seq_U87_Human0.99167200
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99114366
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98784519
95RUNX2_22187159_ChIP-Seq_PCA_Human0.97828375
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94702410
97AR_20517297_ChIP-Seq_VCAP_Human0.91659998
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.91212337
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90666344
100ER_23166858_ChIP-Seq_MCF-7_Human0.90613837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.84413668
2MP0003136_yellow_coat_color4.47210957
3MP0003123_paternal_imprinting3.93484844
4MP0006276_abnormal_autonomic_nervous3.82821317
5MP0003122_maternal_imprinting3.81431677
6MP0005171_absent_coat_pigmentation3.81173923
7MP0003121_genomic_imprinting3.77343208
8MP0002653_abnormal_ependyma_morphology3.63564165
9MP0002163_abnormal_gland_morphology3.38867388
10MP0005423_abnormal_somatic_nervous3.34462731
11MP0003787_abnormal_imprinting2.60520123
12MP0001348_abnormal_lacrimal_gland2.26413544
13MP0004147_increased_porphyrin_level2.23141986
14MP0000569_abnormal_digit_pigmentation2.22056975
15MP0005379_endocrine/exocrine_gland_phen2.16678311
16MP0006292_abnormal_olfactory_placode2.04547072
17MP0000778_abnormal_nervous_system2.00707215
18MP0006054_spinal_hemorrhage2.00165784
19MP0001984_abnormal_olfaction1.91677891
20MP0002254_reproductive_system_inflammat1.90849848
21MP0004142_abnormal_muscle_tone1.88629061
22MP0002638_abnormal_pupillary_reflex1.71768330
23MP0003646_muscle_fatigue1.68559428
24MP0004133_heterotaxia1.63989484
25MP0002876_abnormal_thyroid_physiology1.62567812
26MP0008058_abnormal_DNA_repair1.59961188
27MP0001346_abnormal_lacrimal_gland1.59682171
28MP0005248_abnormal_Harderian_gland1.48169725
29MP0002184_abnormal_innervation1.47114071
30MP0000955_abnormal_spinal_cord1.35995132
31MP0003011_delayed_dark_adaptation1.29932827
32MP0004145_abnormal_muscle_electrophysio1.28812185
33MP0002751_abnormal_autonomic_nervous1.25901027
34MP0005551_abnormal_eye_electrophysiolog1.25046144
35MP0001293_anophthalmia1.23705232
36MP0001529_abnormal_vocalization1.22863791
37MP0005645_abnormal_hypothalamus_physiol1.21637299
38MP0002095_abnormal_skin_pigmentation1.20271993
39MP0002928_abnormal_bile_duct1.19484143
40MP0002938_white_spotting1.19091236
41MP0002752_abnormal_somatic_nervous1.17382860
42MP0001286_abnormal_eye_development1.15292843
43MP0000013_abnormal_adipose_tissue1.13091525
44MP0005253_abnormal_eye_physiology1.12396433
45MP0001986_abnormal_taste_sensitivity1.12060294
46MP0005085_abnormal_gallbladder_physiolo1.11381861
47MP0005167_abnormal_blood-brain_barrier1.09459336
48MP0000647_abnormal_sebaceous_gland1.07615520
49MP0003937_abnormal_limbs/digits/tail_de1.07428732
50MP0005646_abnormal_pituitary_gland1.07053282
51MP0002736_abnormal_nociception_after1.05792116
52MP0010030_abnormal_orbit_morphology1.05578435
53MP0002557_abnormal_social/conspecific_i1.04182889
54MP0004859_abnormal_synaptic_plasticity1.01863352
55MP0003186_abnormal_redox_activity0.99780124
56MP0005195_abnormal_posterior_eye0.95253905
57MP0002233_abnormal_nose_morphology0.94734755
58MP0000049_abnormal_middle_ear0.94719039
59MP0002272_abnormal_nervous_system0.93292271
60MP0009046_muscle_twitch0.90148548
61MP0004484_altered_response_of0.87093598
62MP0005084_abnormal_gallbladder_morpholo0.85795007
63MP0005174_abnormal_tail_pigmentation0.84479582
64MP0002063_abnormal_learning/memory/cond0.84479544
65MP0002837_dystrophic_cardiac_calcinosis0.83998244
66MP0008877_abnormal_DNA_methylation0.83779723
67MP0001324_abnormal_eye_pigmentation0.83360249
68MP0003635_abnormal_synaptic_transmissio0.82865120
69MP0001970_abnormal_pain_threshold0.82666556
70MP0002882_abnormal_neuron_morphology0.81818338
71MP0009745_abnormal_behavioral_response0.79895545
72MP0006072_abnormal_retinal_apoptosis0.78155990
73MP0001963_abnormal_hearing_physiology0.77946224
74MP0002067_abnormal_sensory_capabilities0.76972937
75MP0001919_abnormal_reproductive_system0.76473407
76MP0004858_abnormal_nervous_system0.75950724
77MP0000026_abnormal_inner_ear0.75483071
78MP0005394_taste/olfaction_phenotype0.72771023
79MP0005499_abnormal_olfactory_system0.72771023
80MP0002152_abnormal_brain_morphology0.72283805
81MP0001119_abnormal_female_reproductive0.70553617
82MP0004270_analgesia0.69716393
83MP0001968_abnormal_touch/_nociception0.68190625
84MP0003755_abnormal_palate_morphology0.67605373
85MP0003936_abnormal_reproductive_system0.67002204
86MP0001270_distended_abdomen0.66671616
87MP0004811_abnormal_neuron_physiology0.66194329
88MP0002210_abnormal_sex_determination0.65863270
89MP0008932_abnormal_embryonic_tissue0.63615108
90MP0000653_abnormal_sex_gland0.63189521
91MP0003567_abnormal_fetal_cardiomyocyte0.62203828
92MP0009250_abnormal_appendicular_skeleto0.62007733
93MP0002734_abnormal_mechanical_nocicepti0.61842868
94MP0003878_abnormal_ear_physiology0.61593754
95MP0005377_hearing/vestibular/ear_phenot0.61593754
96MP0001879_abnormal_lymphatic_vessel0.61333407
97MP0005391_vision/eye_phenotype0.60058498
98MP0001486_abnormal_startle_reflex0.59506575
99MP0002116_abnormal_craniofacial_bone0.58524621
100MP0008875_abnormal_xenobiotic_pharmacok0.58497217

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)6.05602180
2Pancreatic cysts (HP:0001737)4.17988776
3Metaphyseal dysplasia (HP:0100255)4.02555389
4Abnormality of midbrain morphology (HP:0002418)4.01575062
5Molar tooth sign on MRI (HP:0002419)4.01575062
6Pancreatic fibrosis (HP:0100732)3.92855662
7Polyphagia (HP:0002591)3.85793619
8Medial flaring of the eyebrow (HP:0010747)3.81442847
9Congenital stationary night blindness (HP:0007642)3.73998499
10Stenosis of the external auditory canal (HP:0000402)3.68425569
11Aplasia/Hypoplasia of the spleen (HP:0010451)3.67804180
12Asplenia (HP:0001746)3.65337594
13Chronic hepatic failure (HP:0100626)3.36656786
14Congenital primary aphakia (HP:0007707)3.30803020
15Gait imbalance (HP:0002141)3.27178576
16Male pseudohermaphroditism (HP:0000037)3.24802041
17Abnormality of glycolysis (HP:0004366)3.22782135
18Abnormal sex determination (HP:0012244)3.18066491
19Sex reversal (HP:0012245)3.18066491
20Papilledema (HP:0001085)2.90344399
21Nephrogenic diabetes insipidus (HP:0009806)2.89512424
22Nephronophthisis (HP:0000090)2.82493014
23Cystic liver disease (HP:0006706)2.80977755
24Occipital encephalocele (HP:0002085)2.74840810
25Reticulocytopenia (HP:0001896)2.73909433
26Fair hair (HP:0002286)2.73517497
27Failure to thrive in infancy (HP:0001531)2.64971815
28Acute necrotizing encephalopathy (HP:0006965)2.62106377
29Exotropia (HP:0000577)2.57910822
30Mitochondrial inheritance (HP:0001427)2.54549442
31Birth length less than 3rd percentile (HP:0003561)2.53291646
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.52790492
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49118980
34Abnormality of the labia minora (HP:0012880)2.48988080
35Anencephaly (HP:0002323)2.48548925
36Gonadotropin excess (HP:0000837)2.47946333
37Vaginal atresia (HP:0000148)2.47801497
38Concave nail (HP:0001598)2.43676118
39Impaired proprioception (HP:0010831)2.43174684
40Narrow forehead (HP:0000341)2.42211026
41Abnormal auditory evoked potentials (HP:0006958)2.42043604
42Genital tract atresia (HP:0001827)2.39998635
43Postaxial foot polydactyly (HP:0001830)2.39627778
44Abnormality of the renal medulla (HP:0100957)2.38785582
45Tubular atrophy (HP:0000092)2.37191899
46Exercise-induced muscle cramps (HP:0003710)2.32175766
47Poor coordination (HP:0002370)2.31447775
48Supernumerary spleens (HP:0009799)2.29198284
49Progressive cerebellar ataxia (HP:0002073)2.28372179
50Large for gestational age (HP:0001520)2.28056970
51Abnormal hemoglobin (HP:0011902)2.26845857
52Specific learning disability (HP:0001328)2.23158774
53Small hand (HP:0200055)2.22332765
54Hypoplasia of the uterus (HP:0000013)2.20001801
55Focal motor seizures (HP:0011153)2.19103566
56Increased CSF lactate (HP:0002490)2.18656706
57Hepatocellular necrosis (HP:0001404)2.18195978
58Hip dysplasia (HP:0001385)2.16755123
59Broad-based gait (HP:0002136)2.16089272
60Shawl scrotum (HP:0000049)2.15487663
61Abnormal mitochondria in muscle tissue (HP:0008316)2.10500623
62Acute encephalopathy (HP:0006846)2.10460251
63Progressive macrocephaly (HP:0004481)2.08794945
64Primary amenorrhea (HP:0000786)2.04516487
65Oligomenorrhea (HP:0000876)2.04181498
66Abnormal tarsal ossification (HP:0008369)2.03298756
67Fibular aplasia (HP:0002990)2.02402756
68Sclerocornea (HP:0000647)2.00176986
69Aplasia/hypoplasia of the uterus (HP:0008684)1.97328465
70Abnormal eating behavior (HP:0100738)1.96652897
71Meckel diverticulum (HP:0002245)1.94558559
72Growth hormone deficiency (HP:0000824)1.93994959
73Postaxial hand polydactyly (HP:0001162)1.90907456
74Cerebral edema (HP:0002181)1.90696985
75Oligodactyly (hands) (HP:0001180)1.90678986
76Poor head control (HP:0002421)1.90173288
77Broad foot (HP:0001769)1.89719032
78Micropenis (HP:0000054)1.87847883
79Abnormal rod and cone electroretinograms (HP:0008323)1.87702729
80Aplasia/Hypoplasia of the breasts (HP:0010311)1.86842459
81Congenital hepatic fibrosis (HP:0002612)1.85621369
82Astigmatism (HP:0000483)1.84336004
83Short foot (HP:0001773)1.83116738
84Irregular epiphyses (HP:0010582)1.82783411
85Abnormality of the ileum (HP:0001549)1.82743794
86Breast aplasia (HP:0100783)1.82556508
87Generalized hypopigmentation of hair (HP:0011358)1.81211522
88Adrenal hypoplasia (HP:0000835)1.81101399
89Hepatic necrosis (HP:0002605)1.80685857
90Dandy-Walker malformation (HP:0001305)1.80338548
91Increased serum pyruvate (HP:0003542)1.78496890
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.78187506
93Aganglionic megacolon (HP:0002251)1.77128694
94Neoplasm of the adrenal cortex (HP:0100641)1.76909200
95Protruding tongue (HP:0010808)1.76463138
96Type II lissencephaly (HP:0007260)1.75595243
97Scrotal hypoplasia (HP:0000046)1.74505978
98Depressed nasal ridge (HP:0000457)1.72522361
99Genetic anticipation (HP:0003743)1.72264358
100Holoprosencephaly (HP:0001360)1.71621235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.09141914
2ZAK3.02779831
3NEK12.98607471
4MKNK22.89031044
5BCR2.81994223
6DYRK22.77639172
7MINK12.72618593
8TRIM282.68298923
9PIK3CA2.39759059
10PINK12.39263948
11MKNK12.15690262
12NTRK21.95672771
13ERBB31.90269340
14MAP2K71.89710338
15BCKDK1.84354625
16EPHB21.84089312
17BMPR21.82471482
18GRK11.64590655
19TIE11.63270482
20DYRK31.58057567
21BMPR1B1.57350162
22SIK31.56235036
23STK161.50681117
24NTRK31.35078348
25MST1R1.33500361
26KSR11.26731732
27TGFBR11.22349267
28CASK1.19032687
29AKT31.14663001
30CDK191.14318375
31EPHA41.14185219
32DYRK1B1.13789611
33PASK1.13605227
34MAPK151.08095930
35PHKG11.05055937
36PHKG21.05055937
37MAP3K41.01622852
38TNIK0.99187463
39FRK0.95605637
40FGFR10.95024779
41PRKCG0.93582637
42TYRO30.92416096
43NUAK10.88970103
44MAPK70.86769483
45EIF2AK30.86215659
46MAP3K120.85990777
47WNK40.85143114
48WNK30.84241428
49FER0.81014377
50PLK40.79970252
51PDK20.74796324
52ADRBK20.73974563
53AURKB0.72179473
54CSNK1G20.71881930
55MARK10.70642349
56VRK10.70213561
57ADRBK10.69136817
58NLK0.67900816
59CAMKK20.67886154
60SRPK10.65853549
61TEC0.64021347
62CCNB10.63031730
63ERBB40.61176239
64TNK20.59964092
65DAPK30.55811119
66CSNK1G10.54885438
67PLK10.51405869
68DYRK1A0.50925513
69CSNK1A1L0.50842888
70PRKACA0.50275587
71CAMK2A0.50250921
72ICK0.50057334
73PAK30.49178851
74GRK70.47448140
75RPS6KA50.47377942
76PIM10.47234665
77PRKCE0.43445453
78AKT20.43001920
79CSNK1A10.42904460
80INSR0.42194681
81CHEK20.41681379
82CSNK1G30.40323805
83WEE10.40048991
84MET0.39808676
85SGK2230.39509886
86SGK4940.39509886
87ITK0.39341136
88MAPK130.38099675
89PLK30.37485672
90CDK80.37292343
91AURKA0.37206753
92PRKCQ0.34679223
93OBSCN0.34344238
94CSNK1E0.33538427
95SRC0.32235767
96IGF1R0.32073915
97EGFR0.31479585
98LRRK20.31247934
99ERBB20.31206863
100INSRR0.28549827

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.44833696
2Protein export_Homo sapiens_hsa030603.76754075
3Oxidative phosphorylation_Homo sapiens_hsa001903.17410423
4Parkinsons disease_Homo sapiens_hsa050123.03345713
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.97767178
6Basal transcription factors_Homo sapiens_hsa030222.84594517
7Fanconi anemia pathway_Homo sapiens_hsa034602.50969961
8Propanoate metabolism_Homo sapiens_hsa006402.18255541
9Steroid biosynthesis_Homo sapiens_hsa001002.16559930
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08536049
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00970429
12Huntingtons disease_Homo sapiens_hsa050161.75706928
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68372895
14Alzheimers disease_Homo sapiens_hsa050101.66215475
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64352882
16RNA degradation_Homo sapiens_hsa030181.60856464
17Cardiac muscle contraction_Homo sapiens_hsa042601.58717353
18Caffeine metabolism_Homo sapiens_hsa002321.55432674
19Basal cell carcinoma_Homo sapiens_hsa052171.53474879
20Phototransduction_Homo sapiens_hsa047441.51328475
21Nitrogen metabolism_Homo sapiens_hsa009101.49080511
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47620583
23Nucleotide excision repair_Homo sapiens_hsa034201.43053899
24Morphine addiction_Homo sapiens_hsa050321.38779833
25Glutamatergic synapse_Homo sapiens_hsa047241.35399256
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35041964
27GABAergic synapse_Homo sapiens_hsa047271.33416129
28Pentose phosphate pathway_Homo sapiens_hsa000301.28061131
29Alcoholism_Homo sapiens_hsa050341.26810087
30Homologous recombination_Homo sapiens_hsa034401.20576122
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.17104047
32Butanoate metabolism_Homo sapiens_hsa006501.16174322
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15774587
34Nicotine addiction_Homo sapiens_hsa050331.14924333
35Taste transduction_Homo sapiens_hsa047421.12496707
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10503513
37Collecting duct acid secretion_Homo sapiens_hsa049661.08666041
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06206865
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03881633
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99853984
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98838231
42Circadian entrainment_Homo sapiens_hsa047130.97793406
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.91527348
44Proteasome_Homo sapiens_hsa030500.91274190
45Tryptophan metabolism_Homo sapiens_hsa003800.91104210
46Linoleic acid metabolism_Homo sapiens_hsa005910.89747091
47Chemical carcinogenesis_Homo sapiens_hsa052040.89665130
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89521941
49Axon guidance_Homo sapiens_hsa043600.89323320
50Hedgehog signaling pathway_Homo sapiens_hsa043400.87183666
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86261104
52Glycerolipid metabolism_Homo sapiens_hsa005610.82405875
53Retinol metabolism_Homo sapiens_hsa008300.80955609
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80170519
55Long-term depression_Homo sapiens_hsa047300.80135845
56Gap junction_Homo sapiens_hsa045400.79903801
57RNA polymerase_Homo sapiens_hsa030200.77807577
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75625035
59Fatty acid degradation_Homo sapiens_hsa000710.75391215
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74473703
61Dopaminergic synapse_Homo sapiens_hsa047280.74108512
62Hippo signaling pathway_Homo sapiens_hsa043900.73882457
63Systemic lupus erythematosus_Homo sapiens_hsa053220.73813984
64Melanogenesis_Homo sapiens_hsa049160.72949960
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68794311
66Dorso-ventral axis formation_Homo sapiens_hsa043200.67605123
67Synaptic vesicle cycle_Homo sapiens_hsa047210.66182421
68Bile secretion_Homo sapiens_hsa049760.65835624
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65344889
70Fatty acid metabolism_Homo sapiens_hsa012120.63445388
71Insulin secretion_Homo sapiens_hsa049110.63347031
72Fatty acid biosynthesis_Homo sapiens_hsa000610.63003236
73Pyruvate metabolism_Homo sapiens_hsa006200.62531854
74Wnt signaling pathway_Homo sapiens_hsa043100.61861958
75Carbon metabolism_Homo sapiens_hsa012000.60454172
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60367609
77Serotonergic synapse_Homo sapiens_hsa047260.59617826
78Metabolic pathways_Homo sapiens_hsa011000.57626267
79Purine metabolism_Homo sapiens_hsa002300.55708583
80Peroxisome_Homo sapiens_hsa041460.53460683
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52619915
82Selenocompound metabolism_Homo sapiens_hsa004500.52468467
83Mismatch repair_Homo sapiens_hsa034300.50862002
84Glutathione metabolism_Homo sapiens_hsa004800.50783873
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50324202
86Tight junction_Homo sapiens_hsa045300.48211139
87Starch and sucrose metabolism_Homo sapiens_hsa005000.47538659
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.47426967
89RNA transport_Homo sapiens_hsa030130.46428438
90One carbon pool by folate_Homo sapiens_hsa006700.44185584
91Pyrimidine metabolism_Homo sapiens_hsa002400.43794878
92Regulation of autophagy_Homo sapiens_hsa041400.43423126
93Ovarian steroidogenesis_Homo sapiens_hsa049130.43413271
94Arachidonic acid metabolism_Homo sapiens_hsa005900.43151144
95Oxytocin signaling pathway_Homo sapiens_hsa049210.42513078
96Olfactory transduction_Homo sapiens_hsa047400.42365240
97Cholinergic synapse_Homo sapiens_hsa047250.41918457
98Salivary secretion_Homo sapiens_hsa049700.37736235
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37575962
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37287619

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