NDUFB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.65299907
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.22746059
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.14541339
4ATP synthesis coupled proton transport (GO:0015986)8.14541339
5* respiratory electron transport chain (GO:0022904)7.43011485
6* electron transport chain (GO:0022900)7.24298201
7viral transcription (GO:0019083)6.43995742
8ribosomal small subunit assembly (GO:0000028)6.35924496
9translational termination (GO:0006415)6.09279121
10ribosomal small subunit biogenesis (GO:0042274)5.81467266
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.54031627
12cotranslational protein targeting to membrane (GO:0006613)5.46187685
13translational elongation (GO:0006414)5.44676845
14protein targeting to ER (GO:0045047)5.43350366
15protein localization to endoplasmic reticulum (GO:0070972)5.19379203
16establishment of protein localization to endoplasmic reticulum (GO:0072599)5.18374623
17maturation of SSU-rRNA (GO:0030490)4.89536283
18viral life cycle (GO:0019058)4.88109852
19oxidative phosphorylation (GO:0006119)4.76100358
20ATP biosynthetic process (GO:0006754)4.74792656
21cellular protein complex disassembly (GO:0043624)4.74143400
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.65979185
23tricarboxylic acid cycle (GO:0006099)4.61955162
24translational initiation (GO:0006413)4.42122511
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.29595196
26purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.21929275
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.21304958
28hydrogen ion transmembrane transport (GO:1902600)4.17930543
29translation (GO:0006412)4.17793259
30protein complex disassembly (GO:0043241)4.17025224
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.15836023
32protein complex biogenesis (GO:0070271)4.09544633
33protein targeting to mitochondrion (GO:0006626)4.03236792
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.99581242
35NADH dehydrogenase complex assembly (GO:0010257)3.99581242
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99581242
37macromolecular complex disassembly (GO:0032984)3.96727716
38GTP biosynthetic process (GO:0006183)3.96119833
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.95540949
40termination of RNA polymerase III transcription (GO:0006386)3.95540949
41inner mitochondrial membrane organization (GO:0007007)3.93820411
42establishment of protein localization to mitochondrion (GO:0072655)3.90175522
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.87197051
44L-phenylalanine catabolic process (GO:0006559)3.87197051
45proteasome assembly (GO:0043248)3.86661965
46ribosomal large subunit biogenesis (GO:0042273)3.86097952
47cytochrome complex assembly (GO:0017004)3.81491429
48cellular ketone body metabolic process (GO:0046950)3.81273403
49branched-chain amino acid catabolic process (GO:0009083)3.80332372
50chaperone-mediated protein transport (GO:0072321)3.78454219
51protein targeting to membrane (GO:0006612)3.78357670
52sarcomere organization (GO:0045214)3.75558752
53cellular component biogenesis (GO:0044085)3.75306424
54respiratory chain complex IV assembly (GO:0008535)3.73506469
55protein localization to mitochondrion (GO:0070585)3.72430941
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.71793826
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71206353
58L-phenylalanine metabolic process (GO:0006558)3.71206353
59mitochondrial respiratory chain complex assembly (GO:0033108)3.71160080
60proton transport (GO:0015992)3.71076296
61NADH metabolic process (GO:0006734)3.70385194
62fatty acid elongation (GO:0030497)3.69286112
63hydrogen transport (GO:0006818)3.66252725
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65131560
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65131560
66UTP biosynthetic process (GO:0006228)3.61141657
67protein maturation by protein folding (GO:0022417)3.58516284
68fatty acid beta-oxidation (GO:0006635)3.57402723
69regulation of oxidative phosphorylation (GO:0002082)3.56173913
70pyrimidine nucleotide catabolic process (GO:0006244)3.55503779
71base-excision repair, AP site formation (GO:0006285)3.55456232
72succinate metabolic process (GO:0006105)3.53647713
73guanosine-containing compound biosynthetic process (GO:1901070)3.53489507
74pseudouridine synthesis (GO:0001522)3.51971702
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51706904
76creatine metabolic process (GO:0006600)3.47439876
77short-chain fatty acid metabolic process (GO:0046459)3.45104156
78aerobic respiration (GO:0009060)3.42507984
79fatty acid catabolic process (GO:0009062)3.38140683
80aspartate family amino acid catabolic process (GO:0009068)3.36425148
81heart process (GO:0003015)3.35458461
82heart contraction (GO:0060047)3.35458461
83UTP metabolic process (GO:0046051)3.34584432
84muscle filament sliding (GO:0030049)3.34233911
85actin-myosin filament sliding (GO:0033275)3.34233911
86sequestering of actin monomers (GO:0042989)3.33618091
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33329231
88ketone body metabolic process (GO:1902224)3.32509910
89protein-cofactor linkage (GO:0018065)3.30380838
90regulation of cellular amino acid metabolic process (GO:0006521)3.29433521
91nuclear-transcribed mRNA catabolic process (GO:0000956)3.29261182
92ribonucleoprotein complex biogenesis (GO:0022613)3.29154404
93pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.26917769
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.25967403
95acetyl-CoA metabolic process (GO:0006084)3.24816034
96branched-chain amino acid metabolic process (GO:0009081)3.24651189
97protein neddylation (GO:0045116)3.24539524
98negative regulation of ligase activity (GO:0051352)3.24485128
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24485128
100aldehyde catabolic process (GO:0046185)3.21872188
101deoxyribonucleotide catabolic process (GO:0009264)3.21403643
102iron-sulfur cluster assembly (GO:0016226)3.20512735
103metallo-sulfur cluster assembly (GO:0031163)3.20512735
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20415361
105CTP metabolic process (GO:0046036)3.19519462
106CTP biosynthetic process (GO:0006241)3.19519462
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17261803
108fatty acid oxidation (GO:0019395)3.16984231
109quinone biosynthetic process (GO:1901663)3.16797955
110ubiquinone biosynthetic process (GO:0006744)3.16797955
111glyoxylate metabolic process (GO:0046487)3.16060168
112deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.14927390
113nucleoside triphosphate biosynthetic process (GO:0009142)3.14190602
114lipid oxidation (GO:0034440)3.11538130
115mRNA catabolic process (GO:0006402)3.11178516
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08902357
117purine nucleotide salvage (GO:0032261)3.07535431
118intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07121934
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07121934
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06423544
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06423544
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06423544
123regulation of acyl-CoA biosynthetic process (GO:0050812)3.06206833
124monocarboxylic acid catabolic process (GO:0072329)3.02601487
125* generation of precursor metabolites and energy (GO:0006091)3.01971205
126deoxyribose phosphate catabolic process (GO:0046386)3.01351348
127rRNA processing (GO:0006364)3.00962856
128ubiquinone metabolic process (GO:0006743)2.99943767
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.99681274
130mitochondrial transport (GO:0006839)2.99368952
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98971245
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.97696090
133central nervous system myelination (GO:0022010)2.97520807
134axon ensheathment in central nervous system (GO:0032291)2.97520807
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95146246
136acyl-CoA metabolic process (GO:0006637)2.93296011
137thioester metabolic process (GO:0035383)2.93296011
138lysine catabolic process (GO:0006554)2.90060325
139lysine metabolic process (GO:0006553)2.90060325
140negative regulation of protein localization to cell surface (GO:2000009)2.85889526
141aromatic amino acid family catabolic process (GO:0009074)2.82545026
142regulation of mitochondrial translation (GO:0070129)2.82176100
143myofibril assembly (GO:0030239)2.81837420
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.79696586
145negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.79190903
146cardiac myofibril assembly (GO:0055003)2.77083215
147establishment of protein localization to mitochondrial membrane (GO:0090151)2.75442388
148purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.74910442
149purine nucleoside monophosphate biosynthetic process (GO:0009127)2.74910442
150oxaloacetate metabolic process (GO:0006107)2.74343884
1512-oxoglutarate metabolic process (GO:0006103)2.74263513
152regulation of cellular respiration (GO:0043457)2.73875382
153carnitine shuttle (GO:0006853)2.73859193
154actin-mediated cell contraction (GO:0070252)2.73837932
155coenzyme catabolic process (GO:0009109)2.72425622
156thioester biosynthetic process (GO:0035384)2.72260051
157acyl-CoA biosynthetic process (GO:0071616)2.72260051
158regulation of cofactor metabolic process (GO:0051193)2.71100577
159regulation of coenzyme metabolic process (GO:0051196)2.71100577
160cardiac muscle tissue morphogenesis (GO:0055008)2.70441590
161sarcoplasmic reticulum calcium ion transport (GO:0070296)2.69709937
162regulation of actin filament-based movement (GO:1903115)2.69088731
163cellular respiration (GO:0045333)2.66920712
164substantia nigra development (GO:0021762)2.66110462
165cardiac muscle contraction (GO:0060048)2.62744466
166regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60430696
167regulation of skeletal muscle contraction (GO:0014819)2.59999956
168regulation of cell communication by electrical coupling (GO:0010649)2.59904583
169purine nucleoside biosynthetic process (GO:0042451)2.57349118
170purine ribonucleoside biosynthetic process (GO:0046129)2.57349118
171cholesterol biosynthetic process (GO:0006695)2.56820876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.96402519
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.56066954
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01621572
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01453877
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.58024703
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.35360131
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23998863
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17345295
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96487805
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.69958921
11* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.67616186
12* XRN2_22483619_ChIP-Seq_HELA_Human2.56182414
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.49640649
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47673080
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47330466
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37952309
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31414855
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29969024
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25439161
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19578933
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18465921
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18387809
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18144536
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17274616
25GABP_19822575_ChIP-Seq_HepG2_Human2.11656975
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.11021304
27TTF2_22483619_ChIP-Seq_HELA_Human2.05504691
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04794451
29VDR_23849224_ChIP-Seq_CD4+_Human2.03048123
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01014034
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.99683087
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.99678573
33FOXP3_21729870_ChIP-Seq_TREG_Human1.99094558
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81715539
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77229891
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75010310
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73444191
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.71033022
39VDR_22108803_ChIP-Seq_LS180_Human1.70564481
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64876762
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61535644
42E2F7_22180533_ChIP-Seq_HELA_Human1.59455467
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56682738
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54940661
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49159615
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48452727
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47088758
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45922432
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.45531046
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44364460
51HTT_18923047_ChIP-ChIP_STHdh_Human1.43447272
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42108582
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39868633
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39035841
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38429272
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38335725
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37914179
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36083565
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.34051177
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31816740
61ELK1_19687146_ChIP-ChIP_HELA_Human1.30781288
62KDM5A_27292631_Chip-Seq_BREAST_Human1.30212374
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29289064
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29280041
65MYC_18940864_ChIP-ChIP_HL60_Human1.28120271
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26845686
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.26829665
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22896559
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22855776
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21787739
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21294821
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20915138
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20052900
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18499098
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.18155529
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18082690
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17970254
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17134662
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16749097
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16065006
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.12948599
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11069920
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10775719
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09469987
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08238971
86CIITA_25753668_ChIP-Seq_RAJI_Human1.08000524
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06362983
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05655898
89TAF15_26573619_Chip-Seq_HEK293_Human1.04801767
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.04725441
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03470796
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01839389
93NANOG_20526341_ChIP-Seq_ESCs_Human1.00606900
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00365339
95BCL6_27268052_Chip-Seq_Bcells_Human0.99683721
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.99679835
97P68_20966046_ChIP-Seq_HELA_Human0.99384444
98EZH2_22144423_ChIP-Seq_EOC_Human0.99136249
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98589044
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98382166
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98162263
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96919673
103ZNF263_19887448_ChIP-Seq_K562_Human0.96909193
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.96093835
105TBX20_22328084_ChIP-Seq_HEART_Mouse0.96093835
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95659065
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94598295
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94276423
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93454861
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93207707
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93162806
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92378134
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91641595
114STAT1_20625510_ChIP-Seq_HELA_Human0.90701712
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90584513
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89936149
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89837411
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89492094
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89352608
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88871302
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87663753
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87214035
123ERG_20517297_ChIP-Seq_VCAP_Human0.87011425
124VDR_21846776_ChIP-Seq_THP-1_Human0.86713504
125E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86585331
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86257893
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86184428
128PHF8_20622854_ChIP-Seq_HELA_Human0.86036609
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.84766852
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84060557
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83935052
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83425931
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.83414276
134DCP1A_22483619_ChIP-Seq_HELA_Human0.83221144
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82475458
136E2F1_20622854_ChIP-Seq_HELA_Human0.81973323
137SA1_27219007_Chip-Seq_Bcells_Human0.81833421
138OCT4_20526341_ChIP-Seq_ESCs_Human0.81438663
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.81374800
140AR_20517297_ChIP-Seq_VCAP_Human0.80732633
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79862560
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79832157
143IRF1_19129219_ChIP-ChIP_H3396_Human0.79514388
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79215080
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.79175736
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78643986
147PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78591912
148NANOG_19829295_ChIP-Seq_ESCs_Human0.78267836
149SOX2_19829295_ChIP-Seq_ESCs_Human0.78267836
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78249727
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77906744
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76527191
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.76419852
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76289664
155AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75036920
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74727610
157TAF2_19829295_ChIP-Seq_ESCs_Human0.74219932
158NCOR_22424771_ChIP-Seq_293T_Human0.73389929
159CTCF_27219007_Chip-Seq_Bcells_Human0.72850231
160CTCF_20526341_ChIP-Seq_ESCs_Human0.72239765
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.72067793
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72048503
163EOMES_21245162_ChIP-Seq_HESCs_Human0.71569553
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71464427
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.71326500
166TRIM28_21343339_ChIP-Seq_HEK293_Human0.70458557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.67120316
2MP0003646_muscle_fatigue3.39917661
3MP0004036_abnormal_muscle_relaxation3.16360095
4MP0004084_abnormal_cardiac_muscle3.08217868
5MP0003806_abnormal_nucleotide_metabolis3.03026375
6MP0006036_abnormal_mitochondrial_physio3.00523473
7MP0003123_paternal_imprinting2.98983899
8MP0006292_abnormal_olfactory_placode2.92740865
9MP0002139_abnormal_hepatobiliary_system2.89684441
10MP0000751_myopathy2.89292814
11MP0003195_calcinosis2.88820731
12MP0000749_muscle_degeneration2.85998353
13MP0004215_abnormal_myocardial_fiber2.80236242
14MP0005360_urolithiasis2.66474644
15MP0005330_cardiomyopathy2.60216741
16MP0005085_abnormal_gallbladder_physiolo2.45652655
17MP0004043_abnormal_pH_regulation2.41481616
18MP0001529_abnormal_vocalization2.39762073
19MP0002653_abnormal_ependyma_morphology2.30306838
20MP0008058_abnormal_DNA_repair2.17893968
21MP0004145_abnormal_muscle_electrophysio2.16730205
22MP0003693_abnormal_embryo_hatching2.16161726
23MP0008789_abnormal_olfactory_epithelium2.15125456
24MP0000372_irregular_coat_pigmentation2.08942212
25MP0010030_abnormal_orbit_morphology2.08276610
26MP0008875_abnormal_xenobiotic_pharmacok2.06811237
27MP0003787_abnormal_imprinting2.03366711
28MP0005451_abnormal_body_composition1.99061318
29MP0005332_abnormal_amino_acid1.98124320
30MP0002972_abnormal_cardiac_muscle1.95984963
31MP0003137_abnormal_impulse_conducting1.87752840
32MP0005365_abnormal_bile_salt1.85165218
33MP0009379_abnormal_foot_pigmentation1.79061983
34MP0005620_abnormal_muscle_contractility1.76167366
35MP0001905_abnormal_dopamine_level1.76095488
36MP0005083_abnormal_biliary_tract1.74591406
37MP0006035_abnormal_mitochondrial_morpho1.74141617
38MP0008995_early_reproductive_senescence1.70230759
39MP0005499_abnormal_olfactory_system1.68778287
40MP0005394_taste/olfaction_phenotype1.68778287
41MP0002938_white_spotting1.68498635
42MP0002736_abnormal_nociception_after1.62687890
43MP0005646_abnormal_pituitary_gland1.59413196
44MP0003121_genomic_imprinting1.55389453
45MP0004087_abnormal_muscle_fiber1.52483136
46MP0002106_abnormal_muscle_physiology1.51558838
47MP0000747_muscle_weakness1.50555124
48MP0008932_abnormal_embryonic_tissue1.50534404
49MP0004130_abnormal_muscle_cell1.49748788
50MP0004957_abnormal_blastocyst_morpholog1.49260819
51MP0008775_abnormal_heart_ventricle1.47001036
52MP0001544_abnormal_cardiovascular_syste1.46209577
53MP0005385_cardiovascular_system_phenoty1.46209577
54MP0004085_abnormal_heartbeat1.45383093
55MP0003950_abnormal_plasma_membrane1.44645210
56MP0003786_premature_aging1.42636809
57MP0004484_altered_response_of1.42197157
58MP0000049_abnormal_middle_ear1.41368768
59MP0003011_delayed_dark_adaptation1.40733508
60MP0000750_abnormal_muscle_regeneration1.39264709
61MP0003186_abnormal_redox_activity1.38047144
62MP0000920_abnormal_myelination1.36163303
63MP0001968_abnormal_touch/_nociception1.33036247
64MP0006138_congestive_heart_failure1.31499376
65MP0005369_muscle_phenotype1.30876226
66MP0005423_abnormal_somatic_nervous1.30738812
67MP0002269_muscular_atrophy1.29960216
68MP0004142_abnormal_muscle_tone1.29273841
69MP0005636_abnormal_mineral_homeostasis1.24902677
70MP0008877_abnormal_DNA_methylation1.23982347
71MP0000230_abnormal_systemic_arterial1.23716811
72MP0005535_abnormal_body_temperature1.23225134
73MP0005584_abnormal_enzyme/coenzyme_acti1.23024227
74MP0005645_abnormal_hypothalamus_physiol1.22959531
75MP0002160_abnormal_reproductive_system1.22209400
76MP0001666_abnormal_nutrient_absorption1.21784697
77MP0003315_abnormal_perineum_morphology1.21451238
78MP0004133_heterotaxia1.19727135
79MP0002118_abnormal_lipid_homeostasis1.19385067
80MP0009643_abnormal_urine_homeostasis1.18739931
81MP0003122_maternal_imprinting1.17275625
82MP0001764_abnormal_homeostasis1.15696370
83MP0003880_abnormal_central_pattern1.15046117
84MP0002332_abnormal_exercise_endurance1.14516749
85MP0000631_abnormal_neuroendocrine_gland1.14515002
86MP0006276_abnormal_autonomic_nervous1.12349159
87MP0000013_abnormal_adipose_tissue1.12016144
88MP0000759_abnormal_skeletal_muscle1.10529226
89MP0004147_increased_porphyrin_level1.09884273
90MP0003718_maternal_effect1.07132317
91MP0010094_abnormal_chromosome_stability1.06975671
92MP0003329_amyloid_beta_deposits1.06583470
93MP0002822_catalepsy1.06574446
94MP0009840_abnormal_foam_cell1.03957816
95MP0001984_abnormal_olfaction1.03925853
96MP0001188_hyperpigmentation1.00707911
97MP0003077_abnormal_cell_cycle1.00376906
98MP0003221_abnormal_cardiomyocyte_apopto0.99904397
99MP0003111_abnormal_nucleus_morphology0.99385267
100MP0005266_abnormal_metabolism0.96122408
101MP0005389_reproductive_system_phenotype0.95074320
102MP0002234_abnormal_pharynx_morphology0.94860952
103MP0001293_anophthalmia0.94657884
104MP0001919_abnormal_reproductive_system0.94506434
105MP0002876_abnormal_thyroid_physiology0.94217938
106MP0002102_abnormal_ear_morphology0.94208401
107MP0010630_abnormal_cardiac_muscle0.93578892
108MP0002210_abnormal_sex_determination0.93571849
109MP0004742_abnormal_vestibular_system0.93507770
110MP0010329_abnormal_lipoprotein_level0.92846123
111MP0002277_abnormal_respiratory_mucosa0.92574805
112MP0002127_abnormal_cardiovascular_syste0.91126439
113MP0002735_abnormal_chemical_nociception0.90245751
114MP0005319_abnormal_enzyme/_coenzyme0.89864898
115MP0001765_abnormal_ion_homeostasis0.89383220
116MP0005408_hypopigmentation0.89174830
117MP0005165_increased_susceptibility_to0.87821307
118MP0002078_abnormal_glucose_homeostasis0.86961380
119MP0000358_abnormal_cell_content/0.85883364
120MP0000026_abnormal_inner_ear0.85793533
121MP0009697_abnormal_copulation0.85751620
122MP0003656_abnormal_erythrocyte_physiolo0.85509885
123MP0002272_abnormal_nervous_system0.85498972
124MP0002095_abnormal_skin_pigmentation0.84977548
125MP0001346_abnormal_lacrimal_gland0.84635228
126MP0001727_abnormal_embryo_implantation0.84532210
127MP0009745_abnormal_behavioral_response0.84102367
128MP0002557_abnormal_social/conspecific_i0.83960159
129MP0003136_yellow_coat_color0.83492234
130MP0009046_muscle_twitch0.83124830
131MP0010386_abnormal_urinary_bladder0.82996328
132MP0003938_abnormal_ear_development0.82692666
133MP0002733_abnormal_thermal_nociception0.82603917
134MP0005379_endocrine/exocrine_gland_phen0.82281334
135MP0008872_abnormal_physiological_respon0.82169937
136MP0006072_abnormal_retinal_apoptosis0.80345446
137MP0004019_abnormal_vitamin_homeostasis0.80119948
138MP0001970_abnormal_pain_threshold0.79679865
139MP0001661_extended_life_span0.78740858
140MP0002752_abnormal_somatic_nervous0.78508712
141MP0005075_abnormal_melanosome_morpholog0.78317444
142MP0002734_abnormal_mechanical_nocicepti0.76977537
143MP0001756_abnormal_urination0.76525265
144MP0002184_abnormal_innervation0.76191674
145MP0005084_abnormal_gallbladder_morpholo0.75558408
146MP0005666_abnormal_adipose_tissue0.75027676
147MP0005376_homeostasis/metabolism_phenot0.73061669
148MP0004924_abnormal_behavior0.72322404
149MP0005386_behavior/neurological_phenoty0.72322404
150MP0001440_abnormal_grooming_behavior0.72232310
151MP0001963_abnormal_hearing_physiology0.70904628
152MP0002229_neurodegeneration0.70216013
153MP0005253_abnormal_eye_physiology0.70130027
154MP0005551_abnormal_eye_electrophysiolog0.69979450
155MP0003191_abnormal_cellular_cholesterol0.69155362
156MP0008007_abnormal_cellular_replicative0.69125964
157MP0002638_abnormal_pupillary_reflex0.68579219
158MP0001145_abnormal_male_reproductive0.68146217
159MP0002132_abnormal_respiratory_system0.67770047
160MP0002971_abnormal_brown_adipose0.65905632
161MP0005670_abnormal_white_adipose0.65243995
162MP0001485_abnormal_pinna_reflex0.62891570
163MP0004381_abnormal_hair_follicle0.62421177
164MP0002163_abnormal_gland_morphology0.62023331

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.39688512
2Abnormal mitochondria in muscle tissue (HP:0008316)6.01135686
3Acute encephalopathy (HP:0006846)5.78338131
4Mitochondrial inheritance (HP:0001427)5.45717779
5Progressive macrocephaly (HP:0004481)5.33699609
6Hepatic necrosis (HP:0002605)5.03929509
7Hepatocellular necrosis (HP:0001404)4.89812411
8Increased CSF lactate (HP:0002490)4.73427016
9Cerebral edema (HP:0002181)4.70957195
10Abnormality of cells of the erythroid lineage (HP:0012130)4.62258777
11Abnormal number of erythroid precursors (HP:0012131)4.46998601
12Reticulocytopenia (HP:0001896)4.35737595
13Lipid accumulation in hepatocytes (HP:0006561)3.96347862
14Increased serum pyruvate (HP:0003542)3.92756178
15Abnormality of glycolysis (HP:0004366)3.92756178
16Increased intramyocellular lipid droplets (HP:0012240)3.82507254
17Increased muscle lipid content (HP:0009058)3.82348887
18Increased hepatocellular lipid droplets (HP:0006565)3.80898252
19Sudden death (HP:0001699)3.75091131
20Lactic acidosis (HP:0003128)3.68208964
21Muscle hypertrophy of the lower extremities (HP:0008968)3.63777834
22Respiratory failure (HP:0002878)3.62775604
23Calf muscle hypertrophy (HP:0008981)3.59628362
24Renal Fanconi syndrome (HP:0001994)3.58514886
25Macrocytic anemia (HP:0001972)3.54423179
26Exercise intolerance (HP:0003546)3.46698418
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.37160703
28Exercise-induced myalgia (HP:0003738)3.32334026
29Myoglobinuria (HP:0002913)3.24001961
30Dicarboxylic aciduria (HP:0003215)3.23258127
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23258127
32Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22915176
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22915176
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.22800425
35Leukodystrophy (HP:0002415)3.22377910
36Optic disc pallor (HP:0000543)3.15887810
37Pheochromocytoma (HP:0002666)3.15580550
38Abnormality of fatty-acid metabolism (HP:0004359)3.15226911
39Ketoacidosis (HP:0001993)3.06740863
40Hypoglycemic coma (HP:0001325)3.06042447
41Exercise-induced muscle cramps (HP:0003710)3.02800564
42Lethargy (HP:0001254)3.01040178
43Neuroendocrine neoplasm (HP:0100634)2.99380037
44Ventricular tachycardia (HP:0004756)2.99043026
45Increased serum lactate (HP:0002151)2.98779837
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96174401
473-Methylglutaconic aciduria (HP:0003535)2.96081149
48Palpitations (HP:0001962)2.94764222
49Ketosis (HP:0001946)2.88923539
50Muscle fiber splitting (HP:0003555)2.88620001
51Glycosuria (HP:0003076)2.88378517
52Abnormality of urine glucose concentration (HP:0011016)2.88378517
53Generalized aminoaciduria (HP:0002909)2.85127209
54Myokymia (HP:0002411)2.73966750
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71525712
56Rhabdomyolysis (HP:0003201)2.68461014
57Pallor (HP:0000980)2.65927850
58Vomiting (HP:0002013)2.51996369
59Abnormality of the calf musculature (HP:0001430)2.49905466
60Methylmalonic aciduria (HP:0012120)2.48814346
61Hyperammonemia (HP:0001987)2.46576690
62Conjunctival hamartoma (HP:0100780)2.45422337
63Type I transferrin isoform profile (HP:0003642)2.44576765
64Abnormality of renal resorption (HP:0011038)2.42721448
65CNS demyelination (HP:0007305)2.39449858
66Abnormality of serine family amino acid metabolism (HP:0010894)2.38908409
67Abnormality of glycine metabolism (HP:0010895)2.38908409
68Dilated cardiomyopathy (HP:0001644)2.37706107
69Hyperglycinuria (HP:0003108)2.37281071
70Methylmalonic acidemia (HP:0002912)2.35065666
71Metabolic acidosis (HP:0001942)2.34581464
72Microvesicular hepatic steatosis (HP:0001414)2.33902334
73Atrial fibrillation (HP:0005110)2.33417554
74Abnormality of alanine metabolism (HP:0010916)2.33263257
75Hyperalaninemia (HP:0003348)2.33263257
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33263257
77Lipoatrophy (HP:0100578)2.32689680
78Hyperphosphaturia (HP:0003109)2.32683306
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31342952
80Respiratory difficulties (HP:0002880)2.31041080
81Exertional dyspnea (HP:0002875)2.30834652
82Syncope (HP:0001279)2.30210818
83Cerebral hemorrhage (HP:0001342)2.26852180
84X-linked dominant inheritance (HP:0001423)2.23161624
85Muscle stiffness (HP:0003552)2.20728460
86Primary atrial arrhythmia (HP:0001692)2.15491287
87Hyporeflexia of lower limbs (HP:0002600)2.15062554
88Supraventricular tachycardia (HP:0004755)2.14750945
89Myopathic facies (HP:0002058)2.14194441
90Cerebral hypomyelination (HP:0006808)2.12350112
91Aplastic anemia (HP:0001915)2.08834654
92Proximal tubulopathy (HP:0000114)2.07002560
93Hyperglycinemia (HP:0002154)2.06802532
94Microretrognathia (HP:0000308)2.06638912
95Supraventricular arrhythmia (HP:0005115)2.06637368
96Testicular atrophy (HP:0000029)2.01793107
97Abnormal urine phosphate concentration (HP:0012599)2.01217273
98EMG: myopathic abnormalities (HP:0003458)1.98883781
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98821997
100Prolonged QT interval (HP:0001657)1.95075864
101Myotonia (HP:0002486)1.94847005
102Gout (HP:0001997)1.92739375
103Colon cancer (HP:0003003)1.92582265
104Ragged-red muscle fibers (HP:0003200)1.91005259
105Emotional lability (HP:0000712)1.88706416
106Abnormal protein glycosylation (HP:0012346)1.87995259
107Abnormal glycosylation (HP:0012345)1.87995259
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87995259
109Abnormal protein N-linked glycosylation (HP:0012347)1.87995259
110Cerebral palsy (HP:0100021)1.85884023
111Blindness (HP:0000618)1.85569136
112Absent thumb (HP:0009777)1.85539166
113Rib fusion (HP:0000902)1.83186873
114Poor suck (HP:0002033)1.83018137
115Muscle fiber atrophy (HP:0100295)1.82645378
116Abnormality of midbrain morphology (HP:0002418)1.82059974
117Molar tooth sign on MRI (HP:0002419)1.82059974
118Pancytopenia (HP:0001876)1.81549799
119Gliosis (HP:0002171)1.81315207
120Abnormal gallbladder morphology (HP:0012437)1.80321852
121Intrahepatic cholestasis (HP:0001406)1.80264782
122Hyperinsulinemic hypoglycemia (HP:0000825)1.78356445
123Reduced antithrombin III activity (HP:0001976)1.77264380
124Sclerocornea (HP:0000647)1.74360471
125Right ventricular cardiomyopathy (HP:0011663)1.72723214
126Hyperlipoproteinemia (HP:0010980)1.71504356
127Cholelithiasis (HP:0001081)1.71386784
128Cholecystitis (HP:0001082)1.68865180
129Abnormal gallbladder physiology (HP:0012438)1.68865180
130Progressive muscle weakness (HP:0003323)1.68591323
131Abnormality of the anterior horn cell (HP:0006802)1.68252656
132Degeneration of anterior horn cells (HP:0002398)1.68252656
133Ventricular arrhythmia (HP:0004308)1.67452421
134Pancreatic fibrosis (HP:0100732)1.66242638
135Progressive microcephaly (HP:0000253)1.65877752
136Multiple enchondromatosis (HP:0005701)1.65820064
137Xanthomatosis (HP:0000991)1.64571190
138Neoplasm of head and neck (HP:0012288)1.64272640
139Esophageal neoplasm (HP:0100751)1.64272640
140Hyperthyroidism (HP:0000836)1.63222882
141Abnormality of serum amino acid levels (HP:0003112)1.63189094
142Opisthotonus (HP:0002179)1.62839440
143Parakeratosis (HP:0001036)1.62413762
144Abnormality of reticulocytes (HP:0004312)1.60003712
145Type 2 muscle fiber atrophy (HP:0003554)1.56061641
146Nausea (HP:0002018)1.55373085
147Abnormality of magnesium homeostasis (HP:0004921)1.51165724
148Cleft eyelid (HP:0000625)1.50919069
149Concave nail (HP:0001598)1.50717730
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.50095912
151Abnormal number of incisors (HP:0011064)1.48095306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.04969514
2BCKDK4.69890926
3MYLK3.79923808
4STK393.57135979
5OBSCN3.50548865
6WNK43.28547846
7TESK22.91063422
8NME12.89760804
9NME22.69535503
10OXSR12.58901869
11PHKG12.48312216
12PHKG22.48312216
13BUB12.47816281
14MUSK2.40294593
15ZAK2.37830849
16ARAF2.28521325
17GRK72.14516347
18TESK12.14450636
19TTN2.08590602
20MAP3K112.06653056
21LMTK22.00182518
22PBK1.88892298
23PDK41.82911745
24PDK31.82911745
25CDC71.82874393
26MST41.82320944
27STK161.79043891
28PINK11.67326203
29MAP2K71.59729221
30BCR1.52877423
31CAMK2D1.51912718
32PKN11.46447675
33TIE11.41884384
34AURKA1.39304133
35ILK1.31773428
36WNK31.29449983
37NUAK11.29323219
38PIK3CG1.26626311
39GRK51.24896926
40LRRK21.21776171
41SRPK11.21497978
42EPHB11.17928945
43PDK21.17178696
44NEK11.16825923
45LIMK11.15533493
46CAMK2G1.14896346
47STK241.14537055
48INSRR1.13770854
49PIK3CA1.12654232
50MAPKAPK51.12305832
51CSNK1G21.06731716
52MAPK151.05592583
53TAF11.04610720
54PAK31.03546116
55CAMK2B1.01246926
56CAMK2A1.01024368
57DYRK30.98961255
58MAP4K20.98243545
59BRSK10.95787362
60UHMK10.95227662
61DAPK10.94521834
62CSNK1A1L0.94424401
63CASK0.94415742
64ADRBK20.91755383
65CCNB10.90097930
66DAPK30.89778086
67ROCK20.89556473
68AURKB0.88246622
69PLK10.87853151
70BRAF0.87163417
71MAP3K120.86362985
72ABL20.86261559
73EPHB20.84630541
74CHEK20.83458685
75PRKCE0.80620589
76PRKD10.80110352
77PRKACA0.78176442
78ADRBK10.77169778
79WNK10.72452454
80CSNK2A20.71280909
81MAPK120.71264979
82MINK10.70432027
83PRKCI0.70185167
84ATR0.70131726
85KDR0.66861592
86MAP3K40.66690163
87CSNK2A10.65869642
88CSNK1G30.64320007
89PRKCQ0.63689178
90PRKCG0.62713383
91CDK80.59969875
92BMPR1B0.58247973
93PAK10.57373738
94DYRK20.56990059
95PLK30.55755185
96DYRK1B0.54995024
97EIF2AK10.53521328
98PLK40.53135600
99MET0.53010061
100CDK11A0.52945261
101TLK10.51917014
102GRK10.51908829
103CDK190.51762953
104CDK140.51688542
105PRPF4B0.51624207
106STK38L0.51222103
107PTK2B0.50477484
108BMPR20.49965438
109RPS6KA40.49364393
110TAOK20.48420507
111SMG10.47665807
112ROCK10.47604878
113SGK2230.47510432
114SGK4940.47510432
115IRAK30.47489735
116CDK150.44918788
117PRKACG0.44283970
118AKT20.43722795
119CDK70.42937717
120PRKACB0.42773602
121CSNK1A10.41392132
122VRK10.40820422
123PNCK0.40624604
124CDK180.40286129
125MARK10.39142268
126PIM20.38598187
127PASK0.38073744
128MAPK130.37334245
129FGR0.36962415
130NTRK10.36493984
131MST1R0.35968288
132CAMK10.35842972
133MAP2K40.35402805
134WEE10.34682778
135STK40.34085031
136RPS6KA50.34003659
137RPS6KB20.33921256
138IRAK20.33880609
139CSNK1G10.33760349
140IRAK10.33686271
141EIF2AK30.33658719
142TRIM280.32240446
143PRKCA0.31947093
144NTRK20.31573991
145PRKG10.31489675
146PDPK10.31482648
147MAP2K20.31186112
148PRKAA20.30784218
149MAPK40.30422852
150CSNK1E0.30279003
151GRK60.30206714
152RPS6KL10.29670490
153RPS6KC10.29670490
154PRKG20.29353270
155EPHA40.25783457
156MAP3K30.25781597
157RPS6KA60.25517680
158ERN10.25482142

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.17213927
2Parkinsons disease_Homo sapiens_hsa050124.47923392
3Alzheimers disease_Homo sapiens_hsa050103.38676263
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17929199
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99787178
6Huntingtons disease_Homo sapiens_hsa050162.90360176
7Fatty acid elongation_Homo sapiens_hsa000622.84606675
8Propanoate metabolism_Homo sapiens_hsa006402.77223801
9Cardiac muscle contraction_Homo sapiens_hsa042602.73548023
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61378934
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60253392
12DNA replication_Homo sapiens_hsa030302.47346174
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25563645
14Protein export_Homo sapiens_hsa030602.22100659
15Butanoate metabolism_Homo sapiens_hsa006502.14912993
16Fatty acid degradation_Homo sapiens_hsa000712.11399683
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08828673
18Base excision repair_Homo sapiens_hsa034102.07102160
19Sulfur metabolism_Homo sapiens_hsa009201.98067578
20Pyruvate metabolism_Homo sapiens_hsa006201.92762181
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90661004
22Mismatch repair_Homo sapiens_hsa034301.86441919
23Fatty acid metabolism_Homo sapiens_hsa012121.83575344
24Ribosome_Homo sapiens_hsa030101.80937172
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78967402
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76641902
27Homologous recombination_Homo sapiens_hsa034401.69003162
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62775301
29Carbon metabolism_Homo sapiens_hsa012001.62633175
30Peroxisome_Homo sapiens_hsa041461.53425039
31Spliceosome_Homo sapiens_hsa030401.50686495
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44822766
33Proteasome_Homo sapiens_hsa030501.41061343
34Tryptophan metabolism_Homo sapiens_hsa003801.39892627
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35248880
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.30125754
37Nucleotide excision repair_Homo sapiens_hsa034201.28269711
38Phenylalanine metabolism_Homo sapiens_hsa003601.23431549
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21949583
40Tyrosine metabolism_Homo sapiens_hsa003501.16158307
41beta-Alanine metabolism_Homo sapiens_hsa004101.15364400
42One carbon pool by folate_Homo sapiens_hsa006701.12576149
43Histidine metabolism_Homo sapiens_hsa003401.12074192
44Arginine and proline metabolism_Homo sapiens_hsa003301.09176919
45Steroid biosynthesis_Homo sapiens_hsa001001.08590448
46Fanconi anemia pathway_Homo sapiens_hsa034601.02720774
47Collecting duct acid secretion_Homo sapiens_hsa049661.00261739
48PPAR signaling pathway_Homo sapiens_hsa033200.95821301
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.94406000
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93604167
51RNA transport_Homo sapiens_hsa030130.93523226
52* Metabolic pathways_Homo sapiens_hsa011000.93285207
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92750717
54Folate biosynthesis_Homo sapiens_hsa007900.91222207
55Glutathione metabolism_Homo sapiens_hsa004800.90572780
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89490847
57RNA degradation_Homo sapiens_hsa030180.87897298
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86340757
59Chemical carcinogenesis_Homo sapiens_hsa052040.85613880
60Arginine biosynthesis_Homo sapiens_hsa002200.83686833
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81235631
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79466947
63Biosynthesis of amino acids_Homo sapiens_hsa012300.79073639
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78789192
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77202129
66Starch and sucrose metabolism_Homo sapiens_hsa005000.74917701
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69995348
68Vibrio cholerae infection_Homo sapiens_hsa051100.69279069
69Basal transcription factors_Homo sapiens_hsa030220.68515272
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66476426
71Synaptic vesicle cycle_Homo sapiens_hsa047210.64257914
72Systemic lupus erythematosus_Homo sapiens_hsa053220.63790144
73Dilated cardiomyopathy_Homo sapiens_hsa054140.63620368
74Sulfur relay system_Homo sapiens_hsa041220.61015414
75Fat digestion and absorption_Homo sapiens_hsa049750.60019087
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.59785978
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.57129002
78Linoleic acid metabolism_Homo sapiens_hsa005910.56444709
79Retinol metabolism_Homo sapiens_hsa008300.50722965
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50419326
81RNA polymerase_Homo sapiens_hsa030200.49636494
82Arachidonic acid metabolism_Homo sapiens_hsa005900.48990937
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47555193
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47210197
85Ether lipid metabolism_Homo sapiens_hsa005650.46654676
86Alcoholism_Homo sapiens_hsa050340.45441008
87Vitamin B6 metabolism_Homo sapiens_hsa007500.40147986
88Selenocompound metabolism_Homo sapiens_hsa004500.36813140
89Complement and coagulation cascades_Homo sapiens_hsa046100.35958340
90Galactose metabolism_Homo sapiens_hsa000520.35659200
91Regulation of autophagy_Homo sapiens_hsa041400.34947313
92Fructose and mannose metabolism_Homo sapiens_hsa000510.34871272
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.34373502
94Glycerolipid metabolism_Homo sapiens_hsa005610.34281030
95N-Glycan biosynthesis_Homo sapiens_hsa005100.33506051
96Pentose phosphate pathway_Homo sapiens_hsa000300.32824207
97Cell cycle_Homo sapiens_hsa041100.32504379
98Non-homologous end-joining_Homo sapiens_hsa034500.32224853
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32046116
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31190489
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.29009542
102Bile secretion_Homo sapiens_hsa049760.25677424
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22262459
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21120569
105Nicotine addiction_Homo sapiens_hsa050330.20917157
106Nitrogen metabolism_Homo sapiens_hsa009100.19743263
107Epstein-Barr virus infection_Homo sapiens_hsa051690.19356286
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19117067
109ABC transporters_Homo sapiens_hsa020100.18521203
110Primary immunodeficiency_Homo sapiens_hsa053400.16323171
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16105465
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16100535
113Basal cell carcinoma_Homo sapiens_hsa052170.15402557
114Pancreatic secretion_Homo sapiens_hsa049720.13969154
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13266526
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12147242
117Sphingolipid metabolism_Homo sapiens_hsa006000.12073195
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11501021
119Serotonergic synapse_Homo sapiens_hsa047260.09820679
120Purine metabolism_Homo sapiens_hsa002300.09780916
121Glucagon signaling pathway_Homo sapiens_hsa049220.09481040
122Pyrimidine metabolism_Homo sapiens_hsa002400.09131931
123Rheumatoid arthritis_Homo sapiens_hsa053230.08868758
124Vitamin digestion and absorption_Homo sapiens_hsa049770.08772149
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.08702271
126Phototransduction_Homo sapiens_hsa047440.08191584
127Taste transduction_Homo sapiens_hsa047420.06507881
128GABAergic synapse_Homo sapiens_hsa047270.06284765
129Caffeine metabolism_Homo sapiens_hsa002320.05993247
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.05825269

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