NDUFB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.64596135
2ATP synthesis coupled proton transport (GO:0015986)8.54335364
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.54335364
4viral transcription (GO:0019083)7.19257832
5* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.98626023
6translational termination (GO:0006415)6.94660282
7* respiratory electron transport chain (GO:0022904)6.88184103
8* electron transport chain (GO:0022900)6.74926773
9ribosomal small subunit assembly (GO:0000028)6.35522168
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.26197311
11cotranslational protein targeting to membrane (GO:0006613)6.23241686
12protein targeting to ER (GO:0045047)6.17310381
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.93812935
14protein complex biogenesis (GO:0070271)5.92351272
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.88821597
16protein localization to endoplasmic reticulum (GO:0070972)5.80632296
17translational elongation (GO:0006414)5.74083047
18ribosomal small subunit biogenesis (GO:0042274)5.69915561
19chaperone-mediated protein transport (GO:0072321)5.68430086
20mitochondrial respiratory chain complex assembly (GO:0033108)5.54522182
21mitochondrial respiratory chain complex I assembly (GO:0032981)5.39577668
22NADH dehydrogenase complex assembly (GO:0010257)5.39577668
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.39577668
24cellular protein complex disassembly (GO:0043624)5.26044389
25viral life cycle (GO:0019058)5.16415423
26protein neddylation (GO:0045116)5.07478247
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.92299608
28maturation of SSU-rRNA (GO:0030490)4.91982065
29hydrogen ion transmembrane transport (GO:1902600)4.79961573
30ATP biosynthetic process (GO:0006754)4.74041786
31translational initiation (GO:0006413)4.69820788
32translation (GO:0006412)4.33667790
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.31595390
34protein complex disassembly (GO:0043241)4.31060878
35purine nucleoside triphosphate biosynthetic process (GO:0009145)4.30765464
36proton transport (GO:0015992)4.27886887
37ribosomal large subunit biogenesis (GO:0042273)4.25845811
38hydrogen transport (GO:0006818)4.19590754
39cytochrome complex assembly (GO:0017004)4.15020082
40macromolecular complex disassembly (GO:0032984)4.13930048
41respiratory chain complex IV assembly (GO:0008535)4.10604284
42protein targeting to membrane (GO:0006612)4.10224130
43termination of RNA polymerase III transcription (GO:0006386)4.03807430
44transcription elongation from RNA polymerase III promoter (GO:0006385)4.03807430
45sequestering of actin monomers (GO:0042989)3.98751093
46regulation of mitochondrial translation (GO:0070129)3.88741644
47ribonucleoside triphosphate biosynthetic process (GO:0009201)3.71988870
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69819647
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.65566187
50inner mitochondrial membrane organization (GO:0007007)3.65334717
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59544193
52proteasome assembly (GO:0043248)3.53845720
53intracellular protein transmembrane import (GO:0044743)3.53534591
54oxidative phosphorylation (GO:0006119)3.53163599
55mRNA catabolic process (GO:0006402)3.44959872
56cellular component biogenesis (GO:0044085)3.38471956
57protein targeting to mitochondrion (GO:0006626)3.37093442
58behavioral response to nicotine (GO:0035095)3.32490078
59mitochondrial transport (GO:0006839)3.32487509
60establishment of protein localization to mitochondrion (GO:0072655)3.32363710
61nucleoside triphosphate biosynthetic process (GO:0009142)3.28774706
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21792543
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21792543
64water-soluble vitamin biosynthetic process (GO:0042364)3.21649427
65protein localization to mitochondrion (GO:0070585)3.16956339
66protein-cofactor linkage (GO:0018065)3.14115340
67RNA catabolic process (GO:0006401)3.09877156
68chromatin remodeling at centromere (GO:0031055)3.07095978
69platelet dense granule organization (GO:0060155)3.05906836
70spliceosomal complex assembly (GO:0000245)3.05263783
71purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.01726992
72purine nucleoside monophosphate biosynthetic process (GO:0009127)3.01726992
73rRNA modification (GO:0000154)2.98665946
74GTP biosynthetic process (GO:0006183)2.97181803
75protein targeting (GO:0006605)2.95358780
76CENP-A containing nucleosome assembly (GO:0034080)2.94436547
77establishment of protein localization to membrane (GO:0090150)2.90244094
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89604727
79establishment of protein localization to organelle (GO:0072594)2.74235015
80ribonucleoprotein complex biogenesis (GO:0022613)2.72416718
81spliceosomal snRNP assembly (GO:0000387)2.72228878
82pseudouridine synthesis (GO:0001522)2.72179860
83intracellular protein transmembrane transport (GO:0065002)2.71338009
84aerobic respiration (GO:0009060)2.67209611
85protein transmembrane transport (GO:0071806)2.66093331
86rRNA processing (GO:0006364)2.61720600
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59303719
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57948077
89negative regulation of ligase activity (GO:0051352)2.57948077
90regulation of oxidative phosphorylation (GO:0002082)2.56815168
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56121211
92rRNA metabolic process (GO:0016072)2.54558766
93organelle disassembly (GO:1903008)2.53287343
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52541666
95ribonucleoside monophosphate biosynthetic process (GO:0009156)2.50471774
96purine ribonucleoside biosynthetic process (GO:0046129)2.47499797
97purine nucleoside biosynthetic process (GO:0042451)2.47499797
98regulation of cellular amino acid metabolic process (GO:0006521)2.47149583
99nucleoside monophosphate biosynthetic process (GO:0009124)2.45120428
1007-methylguanosine mRNA capping (GO:0006370)2.42812459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.24155252
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.56604512
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37901708
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.26940011
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.47550711
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29535567
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07004007
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95221139
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89408467
10ELK1_19687146_ChIP-ChIP_HELA_Human2.65461195
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63393702
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57441575
13EZH2_22144423_ChIP-Seq_EOC_Human2.54415499
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53668196
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51816851
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.40343334
17* VDR_23849224_ChIP-Seq_CD4+_Human2.27183090
18VDR_22108803_ChIP-Seq_LS180_Human2.15440268
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06015422
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.96622759
21ZNF274_21170338_ChIP-Seq_K562_Hela1.95668622
22MYC_18940864_ChIP-ChIP_HL60_Human1.90123130
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90002532
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85811768
25FUS_26573619_Chip-Seq_HEK293_Human1.84199737
26* FOXP3_21729870_ChIP-Seq_TREG_Human1.78648836
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74427274
28EWS_26573619_Chip-Seq_HEK293_Human1.71296746
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68951048
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62429173
31* TTF2_22483619_ChIP-Seq_HELA_Human1.57136493
32IGF1R_20145208_ChIP-Seq_DFB_Human1.54560938
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49907023
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47986031
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44237586
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.43305494
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42260170
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40739139
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40118761
40XRN2_22483619_ChIP-Seq_HELA_Human1.39196773
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.35171273
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34969318
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33456012
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33388156
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.31945374
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31782380
47TAF15_26573619_Chip-Seq_HEK293_Human1.31237066
48* TP53_22573176_ChIP-Seq_HFKS_Human1.30457774
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30286317
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.30014142
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28036129
52DCP1A_22483619_ChIP-Seq_HELA_Human1.26062765
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24999970
54P300_19829295_ChIP-Seq_ESCs_Human1.24705604
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22826278
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22800998
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.22043262
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21137929
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19083671
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18368850
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16550641
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14262479
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12412580
64IRF1_19129219_ChIP-ChIP_H3396_Human1.10797099
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.07650051
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07590271
67ER_23166858_ChIP-Seq_MCF-7_Human1.07518643
68GABP_19822575_ChIP-Seq_HepG2_Human1.07240413
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06002407
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04519248
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03974555
72HTT_18923047_ChIP-ChIP_STHdh_Human1.02129150
73GBX2_23144817_ChIP-Seq_PC3_Human1.01167926
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98569797
75* SOX2_19829295_ChIP-Seq_ESCs_Human0.98427868
76* NANOG_19829295_ChIP-Seq_ESCs_Human0.98427868
77AR_20517297_ChIP-Seq_VCAP_Human0.98408526
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98350450
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.97212878
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97212878
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94397216
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92572633
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92043502
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90678241
85* ERG_20517297_ChIP-Seq_VCAP_Human0.90315942
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87943688
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87658396
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85265463
89NCOR_22424771_ChIP-Seq_293T_Human0.84632184
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83858831
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82820653
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81694452
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.81416739
94BCAT_22108803_ChIP-Seq_LS180_Human0.81002669
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80038706
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79868336
97RNF2_27304074_Chip-Seq_NSC_Mouse0.79779025
98CBP_20019798_ChIP-Seq_JUKART_Human0.78303205
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78303205
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77490966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.92843987
2MP0006292_abnormal_olfactory_placode2.92097482
3MP0002837_dystrophic_cardiac_calcinosis2.85071882
4MP0003136_yellow_coat_color2.56654930
5MP0003646_muscle_fatigue2.48180348
6MP0002638_abnormal_pupillary_reflex2.48018187
7MP0006072_abnormal_retinal_apoptosis2.42638188
8MP0000372_irregular_coat_pigmentation2.29692592
9MP0003011_delayed_dark_adaptation2.28004670
10MP0004142_abnormal_muscle_tone2.20657632
11MP0002938_white_spotting2.18251987
12MP0001529_abnormal_vocalization2.11728150
13MP0003186_abnormal_redox_activity2.00388979
14MP0003806_abnormal_nucleotide_metabolis1.97255462
15MP0003880_abnormal_central_pattern1.84875610
16MP0004145_abnormal_muscle_electrophysio1.84351143
17MP0006036_abnormal_mitochondrial_physio1.84013185
18MP0005551_abnormal_eye_electrophysiolog1.78535912
19MP0001984_abnormal_olfaction1.70920774
20MP0005084_abnormal_gallbladder_morpholo1.64997183
21MP0002277_abnormal_respiratory_mucosa1.62673069
22MP0001485_abnormal_pinna_reflex1.61772810
23MP0008877_abnormal_DNA_methylation1.58523804
24MP0005253_abnormal_eye_physiology1.57226873
25MP0002736_abnormal_nociception_after1.56212633
26MP0010386_abnormal_urinary_bladder1.51482309
27MP0008995_early_reproductive_senescence1.50281899
28MP0002272_abnormal_nervous_system1.49212767
29MP0003787_abnormal_imprinting1.46837231
30MP0009046_muscle_twitch1.44752642
31MP0008875_abnormal_xenobiotic_pharmacok1.44484949
32MP0001968_abnormal_touch/_nociception1.44201560
33MP0000631_abnormal_neuroendocrine_gland1.43867127
34MP0006276_abnormal_autonomic_nervous1.43730991
35MP0001905_abnormal_dopamine_level1.41823801
36MP0009745_abnormal_behavioral_response1.39576029
37MP0001293_anophthalmia1.37532947
38MP0005645_abnormal_hypothalamus_physiol1.37358339
39MP0008058_abnormal_DNA_repair1.35291077
40MP0004133_heterotaxia1.29597064
41MP0010030_abnormal_orbit_morphology1.29492944
42MP0008789_abnormal_olfactory_epithelium1.28011562
43MP0003121_genomic_imprinting1.27453691
44MP0002102_abnormal_ear_morphology1.25518398
45MP0006035_abnormal_mitochondrial_morpho1.23318108
46MP0002653_abnormal_ependyma_morphology1.23183478
47MP0005646_abnormal_pituitary_gland1.23150189
48MP0003195_calcinosis1.21826932
49MP0003123_paternal_imprinting1.17750519
50MP0008872_abnormal_physiological_respon1.16808950
51MP0002160_abnormal_reproductive_system1.15864170
52MP0001919_abnormal_reproductive_system1.13873785
53MP0002163_abnormal_gland_morphology1.13539597
54MP0005389_reproductive_system_phenotype1.12987073
55MP0001486_abnormal_startle_reflex1.12790885
56MP0004742_abnormal_vestibular_system1.11679714
57MP0005423_abnormal_somatic_nervous1.10694801
58MP0003718_maternal_effect1.09839954
59MP0004147_increased_porphyrin_level1.09738520
60MP0005379_endocrine/exocrine_gland_phen1.07438220
61MP0002095_abnormal_skin_pigmentation1.05840780
62MP0005195_abnormal_posterior_eye1.04195180
63MP0002734_abnormal_mechanical_nocicepti1.03836696
64MP0002735_abnormal_chemical_nociception1.03481485
65MP0002064_seizures1.01600514
66MP0001440_abnormal_grooming_behavior0.98288600
67MP0000026_abnormal_inner_ear0.96164823
68MP0004215_abnormal_myocardial_fiber0.96102183
69MP0003137_abnormal_impulse_conducting0.95929093
70MP0002234_abnormal_pharynx_morphology0.95734880
71MP0002822_catalepsy0.95263364
72MP0004885_abnormal_endolymph0.94458860
73MP0001970_abnormal_pain_threshold0.94246214
74MP0002090_abnormal_vision0.94030034
75MP0005332_abnormal_amino_acid0.93896007
76MP0002876_abnormal_thyroid_physiology0.92387013
77MP0003786_premature_aging0.92315935
78MP0002572_abnormal_emotion/affect_behav0.92103468
79MP0002752_abnormal_somatic_nervous0.91223165
80MP0002557_abnormal_social/conspecific_i0.90523008
81MP0001764_abnormal_homeostasis0.90125543
82MP0002067_abnormal_sensory_capabilities0.87007260
83MP0005171_absent_coat_pigmentation0.86854965
84MP0003938_abnormal_ear_development0.84465144
85MP0003122_maternal_imprinting0.84193470
86MP0000749_muscle_degeneration0.82184376
87MP0005377_hearing/vestibular/ear_phenot0.80395795
88MP0003878_abnormal_ear_physiology0.80395795
89MP0005408_hypopigmentation0.79622593
90MP0002210_abnormal_sex_determination0.79314287
91MP0000750_abnormal_muscle_regeneration0.76829217
92MP0002184_abnormal_innervation0.76309411
93MP0005174_abnormal_tail_pigmentation0.76191989
94MP0005499_abnormal_olfactory_system0.75997930
95MP0005394_taste/olfaction_phenotype0.75997930
96MP0001963_abnormal_hearing_physiology0.75501495
97MP0005391_vision/eye_phenotype0.75301361
98MP0002751_abnormal_autonomic_nervous0.72188638
99MP0000049_abnormal_middle_ear0.71992025
100MP0000778_abnormal_nervous_system0.71560368

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.48864032
2Mitochondrial inheritance (HP:0001427)5.87100932
3Abnormal mitochondria in muscle tissue (HP:0008316)5.86154707
4Progressive macrocephaly (HP:0004481)5.47037985
5Acute encephalopathy (HP:0006846)5.45982459
6Increased hepatocellular lipid droplets (HP:0006565)5.32452236
7Lipid accumulation in hepatocytes (HP:0006561)5.11128068
8Increased CSF lactate (HP:0002490)5.02887225
9Hepatocellular necrosis (HP:0001404)4.85117010
10Abnormality of cells of the erythroid lineage (HP:0012130)4.63064772
11Renal Fanconi syndrome (HP:0001994)4.51623186
12Hepatic necrosis (HP:0002605)4.46965122
13Abnormal number of erythroid precursors (HP:0012131)4.38922208
143-Methylglutaconic aciduria (HP:0003535)4.24331798
15Cerebral edema (HP:0002181)4.12458718
16Reticulocytopenia (HP:0001896)4.08562779
17Increased intramyocellular lipid droplets (HP:0012240)4.02629030
18Macrocytic anemia (HP:0001972)3.89051163
19Congenital, generalized hypertrichosis (HP:0004540)3.72246032
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61023958
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61023958
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57130169
23Increased muscle lipid content (HP:0009058)3.51226044
24Exertional dyspnea (HP:0002875)3.40623659
25Respiratory failure (HP:0002878)3.24612863
26Lactic acidosis (HP:0003128)3.13726128
27Optic disc pallor (HP:0000543)3.12364028
28Leukodystrophy (HP:0002415)3.07490990
29Exercise intolerance (HP:0003546)2.98886435
30Abnormality of renal resorption (HP:0011038)2.96698797
31Increased serum lactate (HP:0002151)2.95815096
32Pancreatic fibrosis (HP:0100732)2.81919590
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80981128
34Pancreatic cysts (HP:0001737)2.80622530
35Pallor (HP:0000980)2.72627688
36Abnormality of midbrain morphology (HP:0002418)2.69904739
37Molar tooth sign on MRI (HP:0002419)2.69904739
38Glycosuria (HP:0003076)2.65189309
39Abnormality of urine glucose concentration (HP:0011016)2.65189309
40Septo-optic dysplasia (HP:0100842)2.63610147
41Respiratory difficulties (HP:0002880)2.61431655
42Lethargy (HP:0001254)2.51330530
43True hermaphroditism (HP:0010459)2.43909328
44Medial flaring of the eyebrow (HP:0010747)2.37496148
45Nephronophthisis (HP:0000090)2.35600276
46Colon cancer (HP:0003003)2.33166156
47Hyperphosphaturia (HP:0003109)2.31010560
48Myokymia (HP:0002411)2.30260476
49Methylmalonic acidemia (HP:0002912)2.24249785
50Generalized aminoaciduria (HP:0002909)2.22347044
51Aplastic anemia (HP:0001915)2.13893460
52Oral leukoplakia (HP:0002745)2.12802986
53Sclerocornea (HP:0000647)2.11334638
54CNS demyelination (HP:0007305)2.11052383
55X-linked dominant inheritance (HP:0001423)2.10910348
56Absent thumb (HP:0009777)2.02261503
57Congenital stationary night blindness (HP:0007642)1.98876288
58Methylmalonic aciduria (HP:0012120)1.97686830
59Hypothermia (HP:0002045)1.97276622
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88971797
61Abnormality of alanine metabolism (HP:0010916)1.88971797
62Hyperalaninemia (HP:0003348)1.88971797
63Gait imbalance (HP:0002141)1.84719207
64Type II lissencephaly (HP:0007260)1.84188692
65Concave nail (HP:0001598)1.83955174
66Hyperglycinemia (HP:0002154)1.83831447
67Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82737787
68Abnormality of the renal medulla (HP:0100957)1.79771385
69Stenosis of the external auditory canal (HP:0000402)1.79398990
70Hypoplasia of the pons (HP:0012110)1.78894981
71Male pseudohermaphroditism (HP:0000037)1.77505509
72Congenital primary aphakia (HP:0007707)1.76874833
73Optic nerve hypoplasia (HP:0000609)1.76595259
74Type I transferrin isoform profile (HP:0003642)1.76016911
75Absent septum pellucidum (HP:0001331)1.74574644
76Abnormality of the pons (HP:0007361)1.72734652
77Abnormality of the renal cortex (HP:0011035)1.72145886
78Renal cortical cysts (HP:0000803)1.68961599
79Pendular nystagmus (HP:0012043)1.68324657
80Maternal diabetes (HP:0009800)1.67798527
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67266233
82Dicarboxylic aciduria (HP:0003215)1.67266233
83Blindness (HP:0000618)1.67145012
84Abnormal urine phosphate concentration (HP:0012599)1.66969472
85Nephrogenic diabetes insipidus (HP:0009806)1.62600081
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62491939
87Abnormality of serum amino acid levels (HP:0003112)1.61764097
88Emotional lability (HP:0000712)1.61295601
89Vomiting (HP:0002013)1.60913216
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.57155703
91Calf muscle hypertrophy (HP:0008981)1.57021740
92Muscle hypertrophy of the lower extremities (HP:0008968)1.55925501
93Abnormality of the labia minora (HP:0012880)1.55352835
94Vaginal atresia (HP:0000148)1.55241887
95Anencephaly (HP:0002323)1.54553380
96Renal tubular dysfunction (HP:0000124)1.53775489
97Genital tract atresia (HP:0001827)1.53123111
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.50179878
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.49216133
100Pancytopenia (HP:0001876)1.48643102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.31025931
2ZAK3.65864792
3TLK13.42268230
4STK163.27309001
5VRK12.99492579
6NME12.31810933
7MAP3K122.25044410
8CDC72.15579979
9BMPR1B2.00720103
10OBSCN1.98661854
11ADRBK21.97864865
12DYRK21.94086110
13PINK11.90802482
14WNK31.84725738
15BUB11.84319223
16NME21.77703428
17GRK11.73549825
18MST41.62992733
19BCKDK1.62469615
20MAP4K21.60117903
21PHKG21.44044362
22PHKG11.44044362
23NUAK11.42312121
24PBK1.41903805
25FRK1.40532484
26CASK1.39594648
27TAF11.37403591
28MAP2K71.29598935
29MAP3K41.29286790
30INSRR1.16803659
31SRPK11.08509854
32TNIK1.07177261
33MUSK1.04572788
34RPS6KA51.04550680
35DAPK30.98309957
36PRKCG0.97557900
37ABL20.97140955
38ACVR1B0.97000569
39PNCK0.95764584
40OXSR10.94219239
41MYLK0.92721418
42DYRK30.92268346
43MAPK130.90568070
44MAPK150.86920142
45CSNK1G20.85449566
46PLK30.85105798
47TIE10.84641778
48GRK70.83244254
49BRSK20.81758811
50WEE10.78156254
51CSNK1G10.75674130
52AURKB0.75275400
53ADRBK10.75018067
54CSNK1G30.74882155
55CAMKK20.74845934
56EPHB20.72808656
57PLK10.71558274
58NEK10.71212394
59PLK40.70423890
60PAK30.70153222
61CDK190.69173352
62PKN10.66890511
63EPHA40.66806322
64PDK20.66514542
65TXK0.66021500
66CCNB10.65341876
67LIMK10.64530354
68AURKA0.64379396
69CSNK2A20.64283993
70CHEK20.63170618
71PRKCE0.60692630
72WNK40.59936658
73PRKACA0.58047361
74ILK0.56962643
75MAP2K40.56808997
76CSNK2A10.56735383
77CAMK10.55387044
78MARK10.53832912
79PASK0.53560786
80CDK80.53422104
81STK40.53319085
82CAMK2A0.50796553
83STK390.49341828
84NTRK20.48100550
85EIF2AK30.47706195
86PRKCI0.45865963
87CSNK1A10.44462992
88CSNK1A1L0.44131524
89PRKACB0.44063106
90MAP3K110.38749048
91PRKG10.37678998
92MKNK20.36172649
93PIK3CA0.36090425
94MAPKAPK50.35079243
95IKBKB0.35062774
96PRKCA0.33611399
97ATR0.33162057
98CSNK1E0.32972709
99STK38L0.32864462
100KDR0.32822965

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.80801213
2Ribosome_Homo sapiens_hsa030105.52988232
3Parkinsons disease_Homo sapiens_hsa050124.78596362
4Alzheimers disease_Homo sapiens_hsa050103.44818722
5Huntingtons disease_Homo sapiens_hsa050163.35435066
6Proteasome_Homo sapiens_hsa030503.12035007
7Cardiac muscle contraction_Homo sapiens_hsa042603.09717483
8* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.08673618
9Protein export_Homo sapiens_hsa030602.97054272
10RNA polymerase_Homo sapiens_hsa030202.67597590
11Homologous recombination_Homo sapiens_hsa034402.01833944
12Mismatch repair_Homo sapiens_hsa034301.67387726
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43958547
14Systemic lupus erythematosus_Homo sapiens_hsa053221.35727049
15DNA replication_Homo sapiens_hsa030301.33892258
16Nucleotide excision repair_Homo sapiens_hsa034201.29846675
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28896086
18Fanconi anemia pathway_Homo sapiens_hsa034601.20432859
19Pyrimidine metabolism_Homo sapiens_hsa002401.18368031
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16175939
21Folate biosynthesis_Homo sapiens_hsa007901.13440786
22Spliceosome_Homo sapiens_hsa030401.13166808
23RNA degradation_Homo sapiens_hsa030181.13104358
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09308359
25Phototransduction_Homo sapiens_hsa047441.07576386
26Basal transcription factors_Homo sapiens_hsa030221.05945455
27Collecting duct acid secretion_Homo sapiens_hsa049661.01792412
28Purine metabolism_Homo sapiens_hsa002300.97956744
29Nicotine addiction_Homo sapiens_hsa050330.95843365
30One carbon pool by folate_Homo sapiens_hsa006700.95024515
31Tryptophan metabolism_Homo sapiens_hsa003800.94917794
32Propanoate metabolism_Homo sapiens_hsa006400.94312970
33Maturity onset diabetes of the young_Homo sapiens_hsa049500.92220850
34Butanoate metabolism_Homo sapiens_hsa006500.87555741
35Linoleic acid metabolism_Homo sapiens_hsa005910.86913469
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85956308
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85423164
38Chemical carcinogenesis_Homo sapiens_hsa052040.83975095
39Glutathione metabolism_Homo sapiens_hsa004800.83674293
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81765743
41Pyruvate metabolism_Homo sapiens_hsa006200.81039838
42Alcoholism_Homo sapiens_hsa050340.80849840
43* Metabolic pathways_Homo sapiens_hsa011000.80586022
44Peroxisome_Homo sapiens_hsa041460.80253950
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80210747
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78296321
47Nitrogen metabolism_Homo sapiens_hsa009100.77770375
48Sulfur metabolism_Homo sapiens_hsa009200.77091140
49Caffeine metabolism_Homo sapiens_hsa002320.73021316
50Sulfur relay system_Homo sapiens_hsa041220.71531612
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71339915
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70389516
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67338569
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65733686
55Selenocompound metabolism_Homo sapiens_hsa004500.64736744
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.63544644
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61309890
58Base excision repair_Homo sapiens_hsa034100.59342353
59RNA transport_Homo sapiens_hsa030130.56505221
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55229757
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54695281
62Retinol metabolism_Homo sapiens_hsa008300.54635488
63beta-Alanine metabolism_Homo sapiens_hsa004100.54266183
64Asthma_Homo sapiens_hsa053100.53843547
65Fat digestion and absorption_Homo sapiens_hsa049750.51980319
66Regulation of autophagy_Homo sapiens_hsa041400.51785532
67Fatty acid degradation_Homo sapiens_hsa000710.51761157
68Vitamin digestion and absorption_Homo sapiens_hsa049770.49554683
69Fatty acid elongation_Homo sapiens_hsa000620.49425632
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.48834157
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47665343
72Mineral absorption_Homo sapiens_hsa049780.43313278
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43016844
74Tyrosine metabolism_Homo sapiens_hsa003500.42237611
75Taste transduction_Homo sapiens_hsa047420.39252176
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.38234946
77Morphine addiction_Homo sapiens_hsa050320.38007170
78Steroid biosynthesis_Homo sapiens_hsa001000.37735172
79Arachidonic acid metabolism_Homo sapiens_hsa005900.37154810
80Rheumatoid arthritis_Homo sapiens_hsa053230.35296196
81GABAergic synapse_Homo sapiens_hsa047270.35119038
82Basal cell carcinoma_Homo sapiens_hsa052170.34068365
83Ether lipid metabolism_Homo sapiens_hsa005650.32854988
84Olfactory transduction_Homo sapiens_hsa047400.31196474
85Non-homologous end-joining_Homo sapiens_hsa034500.30233592
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.28410496
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27376105
88Hedgehog signaling pathway_Homo sapiens_hsa043400.26208551
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.26012749
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21442571
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21132848
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20870535
93Glycerolipid metabolism_Homo sapiens_hsa005610.20430166
94Arginine and proline metabolism_Homo sapiens_hsa003300.20108782
95Histidine metabolism_Homo sapiens_hsa003400.19170930
96Vitamin B6 metabolism_Homo sapiens_hsa007500.18981692
97Serotonergic synapse_Homo sapiens_hsa047260.18318790
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17639149
99Pancreatic secretion_Homo sapiens_hsa049720.17398156
100Synaptic vesicle cycle_Homo sapiens_hsa047210.17322487

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