NDUFAF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.95781332
2ATP synthesis coupled proton transport (GO:0015986)6.54631720
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.54631720
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.92657344
5respiratory electron transport chain (GO:0022904)5.31108374
6electron transport chain (GO:0022900)5.23331337
7chaperone-mediated protein transport (GO:0072321)5.04195615
8synaptic vesicle exocytosis (GO:0016079)4.81090261
9neuron cell-cell adhesion (GO:0007158)4.63435646
10respiratory chain complex IV assembly (GO:0008535)4.62783469
11neuronal action potential propagation (GO:0019227)4.57109044
12vocalization behavior (GO:0071625)4.14495632
13* protein complex biogenesis (GO:0070271)3.97606598
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.93400126
15protein localization to synapse (GO:0035418)3.90118529
16cytochrome complex assembly (GO:0017004)3.87946614
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83350010
18* mitochondrial respiratory chain complex I assembly (GO:0032981)3.81690482
19* NADH dehydrogenase complex assembly (GO:0010257)3.81690482
20* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81690482
21dopamine transport (GO:0015872)3.75891997
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.69493878
23ATP hydrolysis coupled proton transport (GO:0015991)3.69493878
24protein-cofactor linkage (GO:0018065)3.63554519
25* mitochondrial respiratory chain complex assembly (GO:0033108)3.61943287
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60890133
27ATP biosynthetic process (GO:0006754)3.59774995
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57100174
29protein neddylation (GO:0045116)3.54160918
30glutamate secretion (GO:0014047)3.45695483
31hydrogen ion transmembrane transport (GO:1902600)3.45578533
32regulation of synaptic vesicle exocytosis (GO:2000300)3.45302347
33negative regulation of microtubule polymerization (GO:0031115)3.40130183
34water-soluble vitamin biosynthetic process (GO:0042364)3.40010073
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38671524
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.33251029
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.32818705
38neuron-neuron synaptic transmission (GO:0007270)3.32746537
39ubiquinone biosynthetic process (GO:0006744)3.32564259
40regulation of catecholamine metabolic process (GO:0042069)3.30435553
41regulation of dopamine metabolic process (GO:0042053)3.30435553
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29050282
43neurotransmitter secretion (GO:0007269)3.27296805
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25365300
45behavioral response to cocaine (GO:0048148)3.25227456
46regulation of glutamate receptor signaling pathway (GO:1900449)3.23914631
47DNA double-strand break processing (GO:0000729)3.23714973
48ubiquinone metabolic process (GO:0006743)3.22588347
49inner mitochondrial membrane organization (GO:0007007)3.22561662
50oxidative phosphorylation (GO:0006119)3.22388320
51glutamate receptor signaling pathway (GO:0007215)3.22163841
52neuron recognition (GO:0008038)3.22061173
53presynaptic membrane assembly (GO:0097105)3.19719953
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.19421915
55regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.18322655
56regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.18322655
57centriole replication (GO:0007099)3.18057667
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17019287
59presynaptic membrane organization (GO:0097090)3.13828292
60replication fork processing (GO:0031297)3.09796917
61regulation of synaptic vesicle transport (GO:1902803)3.09691877
62behavioral response to nicotine (GO:0035095)3.09208538
63NADH metabolic process (GO:0006734)3.08411764
64proton transport (GO:0015992)3.05682110
65catecholamine transport (GO:0051937)3.01596117
66regulation of mitochondrial translation (GO:0070129)3.01108234
67response to pheromone (GO:0019236)2.99724236
68hydrogen transport (GO:0006818)2.99290669
69regulation of glutamate secretion (GO:0014048)2.99252051
70synaptic transmission, glutamatergic (GO:0035249)2.96536033
71positive regulation of synapse assembly (GO:0051965)2.96444732
72regulation of oxidative phosphorylation (GO:0002082)2.95273644
73neurotransmitter transport (GO:0006836)2.95208323
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94189471
75neurotransmitter uptake (GO:0001504)2.93804094
76cullin deneddylation (GO:0010388)2.93093820
77synaptic transmission, dopaminergic (GO:0001963)2.92576014
78transferrin transport (GO:0033572)2.91820499
79startle response (GO:0001964)2.90828295
80calcium-mediated signaling using intracellular calcium source (GO:0035584)2.90751763
81regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89598588
82ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89510879
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89144507
84regulation of mitotic spindle checkpoint (GO:1903504)2.89144507
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87952568
86regulation of protein kinase A signaling (GO:0010738)2.87715310
87rRNA modification (GO:0000154)2.87346371
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87196661
89cellular ketone body metabolic process (GO:0046950)2.86711888
90tricarboxylic acid cycle (GO:0006099)2.85209560
91termination of RNA polymerase III transcription (GO:0006386)2.84622433
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.84622433
93regulation of cellular respiration (GO:0043457)2.83762774
94response to histamine (GO:0034776)2.82565605
95ketone body metabolic process (GO:1902224)2.82275433
96postsynaptic membrane organization (GO:0001941)2.82269679
97cochlea development (GO:0090102)2.82141739
98substantia nigra development (GO:0021762)2.82039411
99regulation of acyl-CoA biosynthetic process (GO:0050812)2.81978380
100negative regulation of neurotransmitter transport (GO:0051589)2.80335187
101transmission of nerve impulse (GO:0019226)2.80154611
102gamma-aminobutyric acid transport (GO:0015812)2.79982687
103proteasome assembly (GO:0043248)2.79393424
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79375799
105protein localization to cilium (GO:0061512)2.77202602
106pyrimidine nucleobase catabolic process (GO:0006208)2.74994328
107establishment of viral latency (GO:0019043)2.74943213
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73295512
109neurotransmitter-gated ion channel clustering (GO:0072578)2.73260058
110single strand break repair (GO:0000012)2.72783483
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72188138
112mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.71889950
113regulation of coenzyme metabolic process (GO:0051196)2.71805296
114regulation of cofactor metabolic process (GO:0051193)2.71805296
115regulation of neurotransmitter levels (GO:0001505)2.71010290
116regulation of synaptic transmission, dopaminergic (GO:0032225)2.70795838
117pseudouridine synthesis (GO:0001522)2.70448396
118protein polyglutamylation (GO:0018095)2.70233637
119protein deneddylation (GO:0000338)2.69932161
120establishment of integrated proviral latency (GO:0075713)2.69470199
121synaptic vesicle transport (GO:0048489)2.67068148
122establishment of synaptic vesicle localization (GO:0097480)2.67068148
123trivalent inorganic cation transport (GO:0072512)2.66078365
124ferric iron transport (GO:0015682)2.66078365
125exploration behavior (GO:0035640)2.65807187
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64957966
127succinate metabolic process (GO:0006105)2.64587993
128detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60776407
129negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57973485
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56248013
131regulation of glucokinase activity (GO:0033131)2.54780102
132regulation of hexokinase activity (GO:1903299)2.54780102
133quinone biosynthetic process (GO:1901663)2.51651809
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.51505418
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47678432
136positive regulation of mitochondrial fission (GO:0090141)2.47447690
137chromatin remodeling at centromere (GO:0031055)2.41436337
138recombinational repair (GO:0000725)2.40798082
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.40261139
140histone H2A acetylation (GO:0043968)2.38347572
141positive regulation of protein homodimerization activity (GO:0090073)2.38067788
142somite development (GO:0061053)2.36779045
143reflex (GO:0060004)2.36046850
144regulation of meiosis I (GO:0060631)2.35944568
145mitochondrial RNA metabolic process (GO:0000959)2.35076112
146platelet dense granule organization (GO:0060155)2.34959136
147double-strand break repair via homologous recombination (GO:0000724)2.34886262
148maturation of 5.8S rRNA (GO:0000460)2.34883251
149intracellular protein transmembrane import (GO:0044743)2.33550151
150neuronal action potential (GO:0019228)2.32402765
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.32398464
152nucleobase catabolic process (GO:0046113)2.31928911
153tRNA processing (GO:0008033)2.31113831
154protein K11-linked deubiquitination (GO:0035871)2.30200685
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29852341
156L-fucose catabolic process (GO:0042355)2.29391035
157fucose catabolic process (GO:0019317)2.29391035
158L-fucose metabolic process (GO:0042354)2.29391035
159regulation of telomere maintenance (GO:0032204)2.27955995
160regulation of centriole replication (GO:0046599)2.27683473
161CENP-A containing nucleosome assembly (GO:0034080)2.27502179
162acrosome reaction (GO:0007340)2.27100134
163nonmotile primary cilium assembly (GO:0035058)2.24333311
164mannosylation (GO:0097502)2.23933802
165DNA deamination (GO:0045006)2.23481779
166transcription elongation from RNA polymerase I promoter (GO:0006362)2.22104482
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.20362318
168tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.20362318
169histone exchange (GO:0043486)2.19995263
170righting reflex (GO:0060013)2.19867133
171detection of light stimulus involved in visual perception (GO:0050908)2.19285419
172detection of light stimulus involved in sensory perception (GO:0050962)2.19285419
173GTP biosynthetic process (GO:0006183)2.17922731
174inositol phosphate catabolic process (GO:0071545)2.15435527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51658412
2GBX2_23144817_ChIP-Seq_PC3_Human3.85670845
3TAF15_26573619_Chip-Seq_HEK293_Human3.10897534
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94196120
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63405914
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54416364
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40955218
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38039900
9REST_21632747_ChIP-Seq_MESCs_Mouse2.33434330
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.31636567
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29904025
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24446118
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23354076
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.21126847
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17628377
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16277645
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09834253
18FUS_26573619_Chip-Seq_HEK293_Human2.09455173
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09412024
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.09160960
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01214590
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.97517864
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97170153
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90860126
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89993814
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88198422
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87981523
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87981523
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83485643
30VDR_22108803_ChIP-Seq_LS180_Human1.82781680
31ELK1_19687146_ChIP-ChIP_HELA_Human1.81265021
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.78705637
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.76775235
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75273827
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74969571
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72753879
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72386840
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71967906
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.70756443
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69498391
41ZNF274_21170338_ChIP-Seq_K562_Hela1.68700245
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68584921
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67394099
44P300_19829295_ChIP-Seq_ESCs_Human1.66810111
45VDR_23849224_ChIP-Seq_CD4+_Human1.64515259
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64359763
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.63363543
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.62915859
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58127797
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.55723175
51MYC_18940864_ChIP-ChIP_HL60_Human1.55694782
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53332040
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52358007
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52318009
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.52004052
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47726675
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46148939
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45742390
59IRF1_19129219_ChIP-ChIP_H3396_Human1.44755282
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44500638
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.43816959
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42066093
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41731908
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41233585
65ER_23166858_ChIP-Seq_MCF-7_Human1.40832237
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40728007
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40636072
68SMAD4_21799915_ChIP-Seq_A2780_Human1.40400626
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38972987
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.38780301
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.37485839
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36125084
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34846692
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33834996
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30654375
76IGF1R_20145208_ChIP-Seq_DFB_Human1.28556076
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28071163
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28071163
79JUN_21703547_ChIP-Seq_K562_Human1.27178699
80STAT3_23295773_ChIP-Seq_U87_Human1.26750537
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26068207
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.25230044
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24020706
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23865680
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22293542
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21685586
87FOXP3_21729870_ChIP-Seq_TREG_Human1.21229202
88BCAT_22108803_ChIP-Seq_LS180_Human1.21113952
89TCF4_23295773_ChIP-Seq_U87_Human1.21019487
90RNF2_27304074_Chip-Seq_NSC_Mouse1.18662867
91EWS_26573619_Chip-Seq_HEK293_Human1.18236680
92SOX2_19829295_ChIP-Seq_ESCs_Human1.16921097
93NANOG_19829295_ChIP-Seq_ESCs_Human1.16921097
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14166441
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13625206
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10876758
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.10855591
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10819478
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10641379
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09994294
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.09489498
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08983588
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08859101
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08628427
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05694828
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05329075
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.05127522
108AR_21572438_ChIP-Seq_LNCaP_Human1.04914390
109AR_25329375_ChIP-Seq_VCAP_Human1.04334727
110TCF4_22108803_ChIP-Seq_LS180_Human1.04217220
111REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03429047
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03112565
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02135990
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.01381357
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99875926
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98397554
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.95276780
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95030500
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.95030500
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94930963
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93996625
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93909021
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.93620136
124GABP_19822575_ChIP-Seq_HepG2_Human0.93427418
125HTT_18923047_ChIP-ChIP_STHdh_Human0.93031201
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92873974
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92732034
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.92413328
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.91433304
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90729075
131SOX9_26525672_Chip-Seq_HEART_Mouse0.87792213
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.86232513
133TP53_22573176_ChIP-Seq_HFKS_Human0.85253987
134CBP_20019798_ChIP-Seq_JUKART_Human0.85251574
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85251574
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85191487
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.85048182
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85031876
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83469391
140DROSHA_22980978_ChIP-Seq_HELA_Human0.82677358
141RUNX2_22187159_ChIP-Seq_PCA_Human0.81987666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.88258300
2MP0004859_abnormal_synaptic_plasticity3.97853540
3MP0003635_abnormal_synaptic_transmissio3.31811069
4MP0001968_abnormal_touch/_nociception3.11978846
5MP0009745_abnormal_behavioral_response3.08232039
6MP0009046_muscle_twitch3.01571225
7MP0001529_abnormal_vocalization2.99317804
8MP0002736_abnormal_nociception_after2.92983115
9MP0002822_catalepsy2.88883562
10MP0002064_seizures2.86286795
11MP0002102_abnormal_ear_morphology2.78397165
12MP0004270_analgesia2.74839090
13MP0006276_abnormal_autonomic_nervous2.70088613
14MP0002063_abnormal_learning/memory/cond2.65216379
15MP0002272_abnormal_nervous_system2.64589539
16MP0001905_abnormal_dopamine_level2.49082124
17MP0003195_calcinosis2.48331368
18MP0002572_abnormal_emotion/affect_behav2.47675762
19MP0002735_abnormal_chemical_nociception2.41458982
20MP0006292_abnormal_olfactory_placode2.32524294
21MP0002837_dystrophic_cardiac_calcinosis2.31480444
22MP0005423_abnormal_somatic_nervous2.27365382
23MP0001486_abnormal_startle_reflex2.26861083
24MP0002734_abnormal_mechanical_nocicepti2.25772133
25MP0000569_abnormal_digit_pigmentation2.25206689
26MP0001501_abnormal_sleep_pattern2.19838474
27MP0001440_abnormal_grooming_behavior2.16037795
28MP0004142_abnormal_muscle_tone2.08995104
29MP0000751_myopathy1.97271414
30MP0002067_abnormal_sensory_capabilities1.95079031
31MP0008058_abnormal_DNA_repair1.92954011
32MP0002733_abnormal_thermal_nociception1.92146304
33MP0005386_behavior/neurological_phenoty1.91655773
34MP0004924_abnormal_behavior1.91655773
35MP0001970_abnormal_pain_threshold1.91604345
36MP0003122_maternal_imprinting1.77280051
37MP0004145_abnormal_muscle_electrophysio1.76627217
38MP0004885_abnormal_endolymph1.71204755
39MP0002184_abnormal_innervation1.69152827
40MP0004147_increased_porphyrin_level1.68308705
41MP0008057_abnormal_DNA_replication1.63139632
42MP0001188_hyperpigmentation1.60415968
43MP0003646_muscle_fatigue1.59122188
44MP0005253_abnormal_eye_physiology1.56294873
45MP0000778_abnormal_nervous_system1.55340467
46MP0002938_white_spotting1.54502944
47MP0001984_abnormal_olfaction1.50866131
48MP0003718_maternal_effect1.50772221
49MP0006036_abnormal_mitochondrial_physio1.50118571
50MP0002557_abnormal_social/conspecific_i1.48003004
51MP0003329_amyloid_beta_deposits1.44269738
52MP0002163_abnormal_gland_morphology1.40560170
53MP0004215_abnormal_myocardial_fiber1.38643295
54MP0005646_abnormal_pituitary_gland1.36632904
55MP0009379_abnormal_foot_pigmentation1.35768293
56MP0003890_abnormal_embryonic-extraembry1.35666030
57MP0008569_lethality_at_weaning1.33503220
58MP0002066_abnormal_motor_capabilities/c1.32246270
59MP0006035_abnormal_mitochondrial_morpho1.32168157
60MP0002638_abnormal_pupillary_reflex1.31550586
61MP0004811_abnormal_neuron_physiology1.30359717
62MP0010094_abnormal_chromosome_stability1.27891673
63MP0005551_abnormal_eye_electrophysiolog1.26117241
64MP0004036_abnormal_muscle_relaxation1.25559278
65MP0001764_abnormal_homeostasis1.24985044
66MP0002882_abnormal_neuron_morphology1.23864039
67MP0000955_abnormal_spinal_cord1.21301783
68MP0005645_abnormal_hypothalamus_physiol1.19803167
69MP0009697_abnormal_copulation1.19745695
70MP0004133_heterotaxia1.19457979
71MP0004043_abnormal_pH_regulation1.18133898
72MP0000749_muscle_degeneration1.17318040
73MP0002138_abnormal_hepatobiliary_system1.16118285
74MP0001986_abnormal_taste_sensitivity1.14993646
75MP0005409_darkened_coat_color1.14597871
76MP0008872_abnormal_physiological_respon1.13893714
77MP0002234_abnormal_pharynx_morphology1.13100470
78MP0005084_abnormal_gallbladder_morpholo1.12769491
79MP0002229_neurodegeneration1.09769963
80MP0005075_abnormal_melanosome_morpholog1.09630394
81MP0003567_abnormal_fetal_cardiomyocyte1.07465886
82MP0003123_paternal_imprinting1.06284033
83MP0001502_abnormal_circadian_rhythm1.03625813
84MP0002132_abnormal_respiratory_system1.03509929
85MP0003879_abnormal_hair_cell1.00364516
86MP0005171_absent_coat_pigmentation0.98171500
87MP0004233_abnormal_muscle_weight0.97607774
88MP0005379_endocrine/exocrine_gland_phen0.95416231
89MP0003283_abnormal_digestive_organ0.95002743
90MP0003186_abnormal_redox_activity0.94809022
91MP0004085_abnormal_heartbeat0.94595282
92MP0000747_muscle_weakness0.93925719
93MP0000631_abnormal_neuroendocrine_gland0.93311519
94MP0002152_abnormal_brain_morphology0.93109257
95MP0002752_abnormal_somatic_nervous0.92799465
96MP0008875_abnormal_xenobiotic_pharmacok0.92751194
97MP0003698_abnormal_male_reproductive0.92224704
98MP0006072_abnormal_retinal_apoptosis0.92029122
99MP0002160_abnormal_reproductive_system0.91297790
100MP0001929_abnormal_gametogenesis0.89901498
101MP0005174_abnormal_tail_pigmentation0.89430855
102MP0005410_abnormal_fertilization0.88588480
103MP0000427_abnormal_hair_cycle0.87578729
104MP0001963_abnormal_hearing_physiology0.87427940
105MP0004484_altered_response_of0.87388115
106MP0002909_abnormal_adrenal_gland0.87298544
107MP0004742_abnormal_vestibular_system0.87279624
108MP0010386_abnormal_urinary_bladder0.86121824
109MP0000013_abnormal_adipose_tissue0.86016263
110MP0002928_abnormal_bile_duct0.85457179
111MP0002210_abnormal_sex_determination0.84936802
112MP0001485_abnormal_pinna_reflex0.84145116
113MP0005332_abnormal_amino_acid0.82113193
114MP0002090_abnormal_vision0.81468787
115MP0003787_abnormal_imprinting0.80735698
116MP0003631_nervous_system_phenotype0.80622019
117MP0002751_abnormal_autonomic_nervous0.80324273
118MP0002095_abnormal_skin_pigmentation0.79057362
119MP0003633_abnormal_nervous_system0.78989070
120MP0003119_abnormal_digestive_system0.78917258
121MP0005195_abnormal_posterior_eye0.77059047
122MP0005394_taste/olfaction_phenotype0.76675779
123MP0005499_abnormal_olfactory_system0.76675779
124MP0003121_genomic_imprinting0.76451600
125MP0004084_abnormal_cardiac_muscle0.76438138
126MP0008877_abnormal_DNA_methylation0.76331244
127MP0005535_abnormal_body_temperature0.76232788
128MP0005620_abnormal_muscle_contractility0.76030043
129MP0003137_abnormal_impulse_conducting0.76012855
130MP0003183_abnormal_peptide_metabolism0.75969963
131MP0002332_abnormal_exercise_endurance0.72765875
132MP0000920_abnormal_myelination0.70151284
133MP0002106_abnormal_muscle_physiology0.70151210
134MP0002876_abnormal_thyroid_physiology0.70079550
135MP0002069_abnormal_eating/drinking_beha0.68978331
136MP0003136_yellow_coat_color0.68463194
137MP0003634_abnormal_glial_cell0.65971426
138MP0000372_irregular_coat_pigmentation0.63981112
139MP0001664_abnormal_digestion0.62385036
140MP0003632_abnormal_nervous_system0.61612319

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.74813429
2* Acute necrotizing encephalopathy (HP:0006965)5.74004121
3* Abnormal mitochondria in muscle tissue (HP:0008316)5.35962602
4* Mitochondrial inheritance (HP:0001427)4.96939346
5* Progressive macrocephaly (HP:0004481)4.84486857
6Myokymia (HP:0002411)4.71031065
7Hepatocellular necrosis (HP:0001404)4.51573625
8* Acute encephalopathy (HP:0006846)4.51338200
9* Increased CSF lactate (HP:0002490)4.36263536
10Atonic seizures (HP:0010819)4.25315094
11Visual hallucinations (HP:0002367)3.97860830
12Abnormality of glycolysis (HP:0004366)3.93483718
13Increased serum pyruvate (HP:0003542)3.93483718
14Focal seizures (HP:0007359)3.76486747
15Pheochromocytoma (HP:0002666)3.73173204
16Neuroendocrine neoplasm (HP:0100634)3.58917626
17Epileptic encephalopathy (HP:0200134)3.51547889
18Hepatic necrosis (HP:0002605)3.48008055
19Absence seizures (HP:0002121)3.40240285
20Pancreatic cysts (HP:0001737)3.39692226
21Febrile seizures (HP:0002373)3.30423958
22Increased hepatocellular lipid droplets (HP:0006565)3.29432356
23* Optic disc pallor (HP:0000543)3.27243899
24Pancreatic fibrosis (HP:0100732)3.25459341
25True hermaphroditism (HP:0010459)3.20868555
26Dialeptic seizures (HP:0011146)3.17094659
27Abnormality of midbrain morphology (HP:0002418)3.16244632
28Molar tooth sign on MRI (HP:0002419)3.16244632
29Nephronophthisis (HP:0000090)3.10097787
30* Exercise intolerance (HP:0003546)2.97143615
31* Lactic acidosis (HP:0003128)2.91912874
32Lipid accumulation in hepatocytes (HP:0006561)2.91526230
33* Leukodystrophy (HP:0002415)2.90214858
34* Cerebral edema (HP:0002181)2.88179459
35* Respiratory failure (HP:0002878)2.86807192
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86160337
37Hyperventilation (HP:0002883)2.84893831
38Progressive cerebellar ataxia (HP:0002073)2.73665603
39Increased intramyocellular lipid droplets (HP:0012240)2.71663913
40Increased serum lactate (HP:0002151)2.70600764
41Limb dystonia (HP:0002451)2.70216644
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68994470
43Renal Fanconi syndrome (HP:0001994)2.68108659
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66855171
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66855171
46Muscle hypertrophy of the lower extremities (HP:0008968)2.66821647
47Generalized tonic-clonic seizures (HP:0002069)2.61997611
48Broad-based gait (HP:0002136)2.59247734
49Abnormality of the renal medulla (HP:0100957)2.54772102
50Delusions (HP:0000746)2.54449919
51Abnormality of the renal cortex (HP:0011035)2.52649188
52Emotional lability (HP:0000712)2.51811017
53Anxiety (HP:0000739)2.48701064
543-Methylglutaconic aciduria (HP:0003535)2.47705015
55Gait imbalance (HP:0002141)2.45875914
56Progressive inability to walk (HP:0002505)2.43605355
57Congenital stationary night blindness (HP:0007642)2.41723822
58Calf muscle hypertrophy (HP:0008981)2.39724622
59Hyperalaninemia (HP:0003348)2.35427880
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35427880
61Abnormality of alanine metabolism (HP:0010916)2.35427880
62Renal cortical cysts (HP:0000803)2.34177436
63* X-linked dominant inheritance (HP:0001423)2.32099020
64Retinal dysplasia (HP:0007973)2.30095528
65Polyphagia (HP:0002591)2.28864289
66Chronic hepatic failure (HP:0100626)2.25632339
67Poor suck (HP:0002033)2.24339369
68Congenital primary aphakia (HP:0007707)2.24183756
69Myotonia (HP:0002486)2.22694218
70Abnormal hair whorl (HP:0010721)2.21566951
71Hypothermia (HP:0002045)2.20144714
72Increased muscle lipid content (HP:0009058)2.20014914
73Abnormality of the labia minora (HP:0012880)2.19877024
74Type II lissencephaly (HP:0007260)2.19370332
75Medial flaring of the eyebrow (HP:0010747)2.18443907
76Protruding tongue (HP:0010808)2.16933404
77Amblyopia (HP:0000646)2.13250722
78Epileptiform EEG discharges (HP:0011182)2.12786843
79Sensory axonal neuropathy (HP:0003390)2.11506858
80Truncal ataxia (HP:0002078)2.08277087
81Failure to thrive in infancy (HP:0001531)2.07575827
82CNS demyelination (HP:0007305)2.07037600
83Methylmalonic acidemia (HP:0002912)2.04933509
84Nephrogenic diabetes insipidus (HP:0009806)2.03849595
85Hyperinsulinemic hypoglycemia (HP:0000825)2.03310104
86Esotropia (HP:0000565)2.03005974
87EEG with generalized epileptiform discharges (HP:0011198)1.99625398
88Cerebral hemorrhage (HP:0001342)1.98401691
89Hypoplastic iliac wings (HP:0002866)1.97450879
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.97009865
91Inability to walk (HP:0002540)1.96077399
92Intestinal atresia (HP:0011100)1.96071606
93Exercise-induced myalgia (HP:0003738)1.95514661
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.95029305
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95029305
96Hyperglycinemia (HP:0002154)1.94949757
97Neoplasm of the peripheral nervous system (HP:0100007)1.94268965
98Short middle phalanx of the 5th finger (HP:0004220)1.93416641
99Genital tract atresia (HP:0001827)1.92878628
100Abnormal eating behavior (HP:0100738)1.91667853
101Gaze-evoked nystagmus (HP:0000640)1.90642393
102Unsteady gait (HP:0002317)1.89058069
103Dysmetria (HP:0001310)1.88570514
104Dysdiadochokinesis (HP:0002075)1.88062979
105Cerebral inclusion bodies (HP:0100314)1.87611012
106Abnormal drinking behavior (HP:0030082)1.87472502
107Polydipsia (HP:0001959)1.87472502
108Respiratory difficulties (HP:0002880)1.87152006
109Cerebral hypomyelination (HP:0006808)1.86415497
110Sclerocornea (HP:0000647)1.86306203
111Impaired vibration sensation in the lower limbs (HP:0002166)1.86214330
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.86202328
113Hypsarrhythmia (HP:0002521)1.86141336
114Vaginal atresia (HP:0000148)1.85374027
115Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84637957
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.84095787
117Large for gestational age (HP:0001520)1.82957998
118Optic nerve hypoplasia (HP:0000609)1.82948209
119Male pseudohermaphroditism (HP:0000037)1.82142242
120Tubular atrophy (HP:0000092)1.82094868
121Bile duct proliferation (HP:0001408)1.80919463
122Abnormal biliary tract physiology (HP:0012439)1.80919463
123Specific learning disability (HP:0001328)1.80306976
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80152421
125Glycosuria (HP:0003076)1.80095341
126Abnormality of urine glucose concentration (HP:0011016)1.80095341
127Abolished electroretinogram (ERG) (HP:0000550)1.78367082
128Abnormality of serum amino acid levels (HP:0003112)1.78148474
129Pendular nystagmus (HP:0012043)1.77623389
130Methylmalonic aciduria (HP:0012120)1.77029359
131Type I transferrin isoform profile (HP:0003642)1.76013644
132Insidious onset (HP:0003587)1.75757156
133Termporal pattern (HP:0011008)1.75757156
134Oligomenorrhea (HP:0000876)1.74732231
135Congenital hepatic fibrosis (HP:0002612)1.73644971
136Lissencephaly (HP:0001339)1.73622996
137Delayed gross motor development (HP:0002194)1.72187298
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71931273
139Anencephaly (HP:0002323)1.71831115
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71726323
141Abnormality of the ileum (HP:0001549)1.71593258
142Meckel diverticulum (HP:0002245)1.71581033
143Abnormality of renal resorption (HP:0011038)1.71521317
144Colon cancer (HP:0003003)1.71151663
145Cystic liver disease (HP:0006706)1.70786387
146Abnormality of the corticospinal tract (HP:0002492)1.70695578
147Spastic gait (HP:0002064)1.69591849
148Abnormality of the phalanges of the 5th finger (HP:0004213)1.69405701
149Chromsome breakage (HP:0040012)1.68528432
150Poor eye contact (HP:0000817)1.68476532
151Abnormality of the pons (HP:0007361)1.67067531
152Generalized myoclonic seizures (HP:0002123)1.67050168
153Abnormal number of erythroid precursors (HP:0012131)1.65819041
154Exercise-induced muscle cramps (HP:0003710)1.65421963
155Acanthocytosis (HP:0001927)1.65007052
156Hypoplasia of the pons (HP:0012110)1.64836126
157Short tibia (HP:0005736)1.64713804
158Drooling (HP:0002307)1.63907411
159Furrowed tongue (HP:0000221)1.63412012
160Abnormal protein N-linked glycosylation (HP:0012347)1.62752152
161Abnormal protein glycosylation (HP:0012346)1.62752152
162Abnormal glycosylation (HP:0012345)1.62752152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.03067072
2MAP3K123.84845300
3CASK3.42799934
4NTRK33.18542968
5MAP2K73.00253853
6BMPR1B2.97025591
7MAP4K22.95918990
8NME12.88400274
9MAP3K42.78631709
10PLK22.45480655
11ARAF2.37051890
12MAP3K92.27251608
13EPHA42.25730709
14MARK12.19224301
15ZAK2.16283007
16ACVR1B2.15316112
17CDK192.13348144
18GRK52.09524278
19TRIM282.02425324
20MINK11.97144106
21NUAK11.96667371
22PNCK1.86872388
23MAP2K41.82047033
24EIF2AK31.71628922
25PHKG11.64711816
26PHKG21.64711816
27PLK41.64341428
28MAPK131.60664335
29DAPK11.57768118
30SRPK11.57139346
31OXSR11.54891697
32GRK11.40417727
33NME21.39224725
34PDK31.37732799
35PDK41.37732799
36STK161.35544439
37CCNB11.35428704
38TSSK61.34861160
39TNIK1.34267246
40ERBB31.32936064
41OBSCN1.28818948
42UHMK11.28746450
43CDC71.28605421
44MKNK11.27014939
45GRK71.27011015
46ADRBK21.24337008
47PAK31.21898965
48MYLK1.19123974
49CAMK2A1.17693655
50BRAF1.14691600
51CAMK2B1.09842111
52STK391.09118194
53KSR21.06207611
54PRKCG1.06195756
55PTK2B1.05925509
56CDK51.05474139
57DAPK21.05201095
58BCR1.04613280
59VRK21.02937727
60AKT31.00297798
61KSR10.99492651
62LIMK10.99015162
63RIPK40.98096368
64NTRK20.97546983
65BUB10.94300033
66TAF10.92327174
67FGR0.92149082
68CAMK2D0.90631046
69CDK140.90134811
70GRK60.87955267
71CDK180.87039612
72INSRR0.86795333
73STK38L0.86668746
74NTRK10.86661596
75ADRBK10.85574485
76CSNK1G30.84991248
77BCKDK0.82635810
78CDK150.82008343
79BMPR20.81432023
80FES0.81139220
81PLK10.80253577
82MST40.79246235
83BRSK20.78054336
84SIK20.78026930
85CSNK1G20.77483327
86EIF2AK10.76626285
87PAK60.75199016
88MUSK0.75175399
89PLK30.75039112
90CDK11A0.74635678
91STK30.74200658
92NEK10.72114766
93CSNK1A1L0.67485971
94CAMK2G0.67280160
95DYRK20.66324072
96PRPF4B0.64965197
97CAMKK20.63118510
98DYRK1A0.63028584
99LATS20.62823191
100PBK0.61642314
101DAPK30.60869618
102CDK30.60619280
103RAF10.59692473
104TGFBR10.59557693
105PRKCE0.59356991
106CDK80.59307653
107VRK10.58625118
108MAP3K130.57559309
109ROCK20.56558031
110PDK20.53369597
111PRKCI0.53276051
112FGFR20.52957474
113WEE10.52606635
114PKN10.52279031
115CHEK20.51962123
116LMTK20.51872050
117EIF2AK20.50976995
118PRKACA0.50598484
119DYRK30.50059040
120WNK30.49994327
121MAPKAPK50.49568903
122ATR0.49254552
123CSNK1E0.48855250
124NEK20.48580863
125WNK40.48380553
126CSNK1A10.47823626
127ATM0.46513372
128TLK10.46425581
129STK240.45731066
130MAP2K10.44118943
131PINK10.43887536
132SGK4940.42992189
133SGK2230.42992189
134RPS6KA50.42244836
135CSNK1G10.41627230
136AURKB0.41581911
137MAPK120.40424026
138TNK20.40418012
139PRKG10.39992016
140PRKACB0.39770794
141TTK0.39235412
142SIK30.36336402
143ILK0.36148239
144BRSK10.35937264
145TAOK30.35292594
146CLK10.35234481
147MKNK20.34270708

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.07713166
2Parkinsons disease_Homo sapiens_hsa050124.36418907
3Alzheimers disease_Homo sapiens_hsa050103.49753720
4Nicotine addiction_Homo sapiens_hsa050333.34056785
5Synaptic vesicle cycle_Homo sapiens_hsa047213.08968097
6Huntingtons disease_Homo sapiens_hsa050163.06360891
7Collecting duct acid secretion_Homo sapiens_hsa049662.71775151
8Cardiac muscle contraction_Homo sapiens_hsa042602.63161571
9Proteasome_Homo sapiens_hsa030502.37857790
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36875380
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23216086
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22507374
13GABAergic synapse_Homo sapiens_hsa047272.00144111
14Long-term potentiation_Homo sapiens_hsa047201.86124597
15Selenocompound metabolism_Homo sapiens_hsa004501.82220266
16Olfactory transduction_Homo sapiens_hsa047401.78246545
17Circadian entrainment_Homo sapiens_hsa047131.77746462
18Morphine addiction_Homo sapiens_hsa050321.77056030
19Amphetamine addiction_Homo sapiens_hsa050311.76758872
20Homologous recombination_Homo sapiens_hsa034401.76485273
21Dopaminergic synapse_Homo sapiens_hsa047281.73076863
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70925938
23RNA degradation_Homo sapiens_hsa030181.68911752
24Glutamatergic synapse_Homo sapiens_hsa047241.67219839
25Serotonergic synapse_Homo sapiens_hsa047261.64251826
26Fanconi anemia pathway_Homo sapiens_hsa034601.64023317
27Vibrio cholerae infection_Homo sapiens_hsa051101.63725774
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62983220
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.62394602
30Phototransduction_Homo sapiens_hsa047441.62180689
31Taste transduction_Homo sapiens_hsa047421.60041221
32Ribosome_Homo sapiens_hsa030101.55284192
33Non-homologous end-joining_Homo sapiens_hsa034501.41816155
34RNA polymerase_Homo sapiens_hsa030201.34957657
35Long-term depression_Homo sapiens_hsa047301.33783715
36Salivary secretion_Homo sapiens_hsa049701.33354333
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31594387
38One carbon pool by folate_Homo sapiens_hsa006701.31090919
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30811111
40Calcium signaling pathway_Homo sapiens_hsa040201.26883432
41RNA transport_Homo sapiens_hsa030131.23209882
42Linoleic acid metabolism_Homo sapiens_hsa005911.21953633
43Mismatch repair_Homo sapiens_hsa034301.21313494
44Cholinergic synapse_Homo sapiens_hsa047251.20882948
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18550978
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.18277066
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17940610
48Nitrogen metabolism_Homo sapiens_hsa009101.17001304
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16961430
50Insulin secretion_Homo sapiens_hsa049111.14468228
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14283750
52Peroxisome_Homo sapiens_hsa041461.12797506
53Cocaine addiction_Homo sapiens_hsa050301.12235228
54Renin secretion_Homo sapiens_hsa049241.10967081
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10733548
56Nucleotide excision repair_Homo sapiens_hsa034201.08634257
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06958448
58Pyruvate metabolism_Homo sapiens_hsa006201.05868302
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05361716
60Fatty acid elongation_Homo sapiens_hsa000621.02652386
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02319237
62Oxytocin signaling pathway_Homo sapiens_hsa049210.97939747
63Gastric acid secretion_Homo sapiens_hsa049710.96879047
64beta-Alanine metabolism_Homo sapiens_hsa004100.96610792
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92976422
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92521742
67Regulation of autophagy_Homo sapiens_hsa041400.92186176
68Tryptophan metabolism_Homo sapiens_hsa003800.89637348
69Base excision repair_Homo sapiens_hsa034100.88086516
70Gap junction_Homo sapiens_hsa045400.87512298
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84574140
72Oocyte meiosis_Homo sapiens_hsa041140.83228573
73Protein export_Homo sapiens_hsa030600.82422559
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.80337815
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77150265
76Fatty acid metabolism_Homo sapiens_hsa012120.75287616
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73383043
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70920430
79Chemical carcinogenesis_Homo sapiens_hsa052040.69381262
80Circadian rhythm_Homo sapiens_hsa047100.68398709
81DNA replication_Homo sapiens_hsa030300.68371431
82Fatty acid degradation_Homo sapiens_hsa000710.67780028
83GnRH signaling pathway_Homo sapiens_hsa049120.63446347
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62579230
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.61488184
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61227559
87Rheumatoid arthritis_Homo sapiens_hsa053230.59751202
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59539836
89Alcoholism_Homo sapiens_hsa050340.59155808
90Retinol metabolism_Homo sapiens_hsa008300.58983605
91Vitamin B6 metabolism_Homo sapiens_hsa007500.57200197
92Folate biosynthesis_Homo sapiens_hsa007900.56050522
93Purine metabolism_Homo sapiens_hsa002300.55537036
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55438573
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54486296
96Carbon metabolism_Homo sapiens_hsa012000.53745311
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53630374
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52123333
99mRNA surveillance pathway_Homo sapiens_hsa030150.50753725
100Axon guidance_Homo sapiens_hsa043600.50488909
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49655202
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49325804
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48699746
104Arginine and proline metabolism_Homo sapiens_hsa003300.48398885
105Metabolic pathways_Homo sapiens_hsa011000.46877217
106Melanogenesis_Homo sapiens_hsa049160.46491322
107Caffeine metabolism_Homo sapiens_hsa002320.45364280
108Dilated cardiomyopathy_Homo sapiens_hsa054140.45261712
109cAMP signaling pathway_Homo sapiens_hsa040240.44964208
110Butanoate metabolism_Homo sapiens_hsa006500.44817790
111Sulfur relay system_Homo sapiens_hsa041220.42403426
112Propanoate metabolism_Homo sapiens_hsa006400.42027450
113Phagosome_Homo sapiens_hsa041450.41753527
114Lysine degradation_Homo sapiens_hsa003100.40867040
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40737387
116Glucagon signaling pathway_Homo sapiens_hsa049220.40725737
117ABC transporters_Homo sapiens_hsa020100.40308335
118Tyrosine metabolism_Homo sapiens_hsa003500.40195840
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39504200
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39445272
121Pyrimidine metabolism_Homo sapiens_hsa002400.38290723
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37494797
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37452269
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.36520263
125Sulfur metabolism_Homo sapiens_hsa009200.34625722
126Estrogen signaling pathway_Homo sapiens_hsa049150.34567038
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33458462
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32240493
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30518627
130Pancreatic secretion_Homo sapiens_hsa049720.28340601
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27587371
132Basal transcription factors_Homo sapiens_hsa030220.26701820
133Ether lipid metabolism_Homo sapiens_hsa005650.25190489
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24970708
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24111076
136Thyroid hormone synthesis_Homo sapiens_hsa049180.23292864
137Spliceosome_Homo sapiens_hsa030400.22833447
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21616585
139Type I diabetes mellitus_Homo sapiens_hsa049400.21265547
140Biosynthesis of amino acids_Homo sapiens_hsa012300.19348901
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18564094
142MAPK signaling pathway_Homo sapiens_hsa040100.17841722
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17395489
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17301384
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16526465
146Steroid biosynthesis_Homo sapiens_hsa001000.16423386
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16391297

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