NDUFAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.08665329
2central nervous system myelination (GO:0022010)6.76737071
3axon ensheathment in central nervous system (GO:0032291)6.76737071
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.65165170
5ATP synthesis coupled proton transport (GO:0015986)6.65165170
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.42695908
7protein neddylation (GO:0045116)5.90605566
8* respiratory electron transport chain (GO:0022904)5.47525888
9chaperone-mediated protein transport (GO:0072321)5.38713070
10fatty acid elongation (GO:0030497)5.37860610
11* electron transport chain (GO:0022900)5.31955261
12long-chain fatty acid biosynthetic process (GO:0042759)4.80981314
13proteasome assembly (GO:0043248)4.57662558
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.56952999
15NADH dehydrogenase complex assembly (GO:0010257)4.56952999
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56952999
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.43135188
18ribosomal small subunit biogenesis (GO:0042274)4.34285586
19protein complex biogenesis (GO:0070271)4.32575433
20cholesterol biosynthetic process (GO:0006695)4.13098366
21translational initiation (GO:0006413)4.10457564
22chromatin remodeling at centromere (GO:0031055)4.00227879
23rRNA modification (GO:0000154)3.97455223
24termination of RNA polymerase III transcription (GO:0006386)3.96945003
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.96945003
26mitochondrial respiratory chain complex assembly (GO:0033108)3.90203298
27CENP-A containing nucleosome assembly (GO:0034080)3.88532520
28cullin deneddylation (GO:0010388)3.83884816
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78193894
30ribonucleoprotein complex biogenesis (GO:0022613)3.78177258
31isoprenoid biosynthetic process (GO:0008299)3.75259022
32GTP biosynthetic process (GO:0006183)3.73647942
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67379537
34sterol biosynthetic process (GO:0016126)3.67141399
35rRNA processing (GO:0006364)3.65626892
36myelination (GO:0042552)3.64624073
37pseudouridine synthesis (GO:0001522)3.60351264
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60249859
39axon ensheathment (GO:0008366)3.59936609
40ensheathment of neurons (GO:0007272)3.59936609
41establishment of integrated proviral latency (GO:0075713)3.56505596
427-methylguanosine mRNA capping (GO:0006370)3.55797351
43RNA capping (GO:0036260)3.55420304
447-methylguanosine RNA capping (GO:0009452)3.55420304
45protein deneddylation (GO:0000338)3.53754463
46substantia nigra development (GO:0021762)3.53571178
47rRNA metabolic process (GO:0016072)3.49896626
48oxidative phosphorylation (GO:0006119)3.49399573
49spliceosomal snRNP assembly (GO:0000387)3.48213093
50viral transcription (GO:0019083)3.48104330
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43989305
52cotranslational protein targeting to membrane (GO:0006613)3.41540002
53translational termination (GO:0006415)3.40335298
54respiratory chain complex IV assembly (GO:0008535)3.35661940
55hydrogen ion transmembrane transport (GO:1902600)3.34052956
56protein targeting to mitochondrion (GO:0006626)3.32938490
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31072004
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31072004
59protein targeting to ER (GO:0045047)3.29890652
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.29738769
61DNA damage response, detection of DNA damage (GO:0042769)3.29701933
62DNA replication checkpoint (GO:0000076)3.27095427
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25561910
64formation of translation preinitiation complex (GO:0001731)3.25487300
65purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25089440
66establishment of viral latency (GO:0019043)3.24875634
67ribosomal large subunit biogenesis (GO:0042273)3.23569098
68rRNA methylation (GO:0031167)3.21214137
69protein complex disassembly (GO:0043241)3.20278335
70histone exchange (GO:0043486)3.19664253
71inner mitochondrial membrane organization (GO:0007007)3.19355395
72protein localization to endoplasmic reticulum (GO:0070972)3.18816986
73establishment of protein localization to mitochondrion (GO:0072655)3.18685626
74water-soluble vitamin biosynthetic process (GO:0042364)3.18320070
75ATP biosynthetic process (GO:0006754)3.17193291
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16480665
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16162519
78maturation of SSU-rRNA (GO:0030490)3.13907484
79UTP biosynthetic process (GO:0006228)3.13628693
80macromolecular complex disassembly (GO:0032984)3.13220171
81telomere maintenance via semi-conservative replication (GO:0032201)3.12898765
82protein targeting to membrane (GO:0006612)3.11580893
83ribosomal small subunit assembly (GO:0000028)3.10299310
84maturation of 5.8S rRNA (GO:0000460)3.07157994
85GPI anchor biosynthetic process (GO:0006506)3.06891703
86microtubule polymerization or depolymerization (GO:0031109)3.06415175
87purine nucleobase biosynthetic process (GO:0009113)3.05448229
88response to redox state (GO:0051775)3.05296569
89mitochondrial transport (GO:0006839)3.05083864
90mannosylation (GO:0097502)3.04001195
91proton transport (GO:0015992)3.03882893
92nuclear-transcribed mRNA catabolic process (GO:0000956)3.03765958
93positive regulation of ligase activity (GO:0051351)3.02243360
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02160675
95intracellular protein transmembrane import (GO:0044743)3.00781159
96protein-cofactor linkage (GO:0018065)2.99823164
97translation (GO:0006412)2.99554272
98negative regulation of protein localization to cell surface (GO:2000009)2.99511851
99ubiquinone metabolic process (GO:0006743)2.99208343
100DNA strand elongation involved in DNA replication (GO:0006271)2.98983907
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98464324
102signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98440517
103signal transduction involved in DNA damage checkpoint (GO:0072422)2.98440517
104regulation of cellular amino acid metabolic process (GO:0006521)2.97607619
105transcription-coupled nucleotide-excision repair (GO:0006283)2.96798030
106hydrogen transport (GO:0006818)2.94373796
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.93709613
108protein localization to mitochondrion (GO:0070585)2.93505438
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93136305
110negative regulation of ligase activity (GO:0051352)2.93136305
111glycerophospholipid catabolic process (GO:0046475)2.89818416
112cellular protein complex disassembly (GO:0043624)2.83748457
113ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82103298
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82015567
115quinone biosynthetic process (GO:1901663)2.81748874
116ubiquinone biosynthetic process (GO:0006744)2.81748874
117guanosine-containing compound biosynthetic process (GO:1901070)2.80740607
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80254226
119preassembly of GPI anchor in ER membrane (GO:0016254)2.80221459
120cellular component biogenesis (GO:0044085)2.80052506
121negative regulation of neurotransmitter transport (GO:0051589)2.79310477
122amino acid salvage (GO:0043102)2.77320979
123L-methionine salvage (GO:0071267)2.77320979
124L-methionine biosynthetic process (GO:0071265)2.77320979
125viral life cycle (GO:0019058)2.76517217
126GPI anchor metabolic process (GO:0006505)2.75442452
127translational elongation (GO:0006414)2.73437200
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73206916
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72952633
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72952633
131peptidyl-histidine modification (GO:0018202)2.71716703
132regulation of mitochondrial translation (GO:0070129)2.71527534
133transcription from RNA polymerase I promoter (GO:0006360)2.71215522
134cytochrome complex assembly (GO:0017004)2.71212440
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68902868
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68902868
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68902868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.40869736
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68659209
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.23031471
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.80413869
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.61788861
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20807889
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.17273998
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.10305902
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08896492
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00156240
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99647705
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.87129431
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75351782
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.56421270
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27718724
16TAF15_26573619_Chip-Seq_HEK293_Human2.19747299
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14348379
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09621121
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.03049185
20THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97152201
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95741760
22VDR_23849224_ChIP-Seq_CD4+_Human1.89251190
23FUS_26573619_Chip-Seq_HEK293_Human1.87200000
24DCP1A_22483619_ChIP-Seq_HELA_Human1.81545013
25ELK1_19687146_ChIP-ChIP_HELA_Human1.77969924
26GBX2_23144817_ChIP-Seq_PC3_Human1.71688540
27VDR_22108803_ChIP-Seq_LS180_Human1.70881017
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69989114
29IRF1_19129219_ChIP-ChIP_H3396_Human1.67910278
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67895962
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62711297
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62151781
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61671417
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61486651
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.61145794
36AR_21909140_ChIP-Seq_LNCAP_Human1.53030594
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51387214
38FOXP3_21729870_ChIP-Seq_TREG_Human1.50785903
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50237482
40ER_23166858_ChIP-Seq_MCF-7_Human1.49239822
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48756376
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48296656
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48264785
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.48184330
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47627253
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.44561135
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43628648
48TTF2_22483619_ChIP-Seq_HELA_Human1.43034627
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.40906380
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39589300
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38967197
52XRN2_22483619_ChIP-Seq_HELA_Human1.38678380
53EWS_26573619_Chip-Seq_HEK293_Human1.34796483
54MYC_18940864_ChIP-ChIP_HL60_Human1.33061643
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30400710
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27319783
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26600737
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25921235
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.23741012
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22548351
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22427858
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22146382
63E2F7_22180533_ChIP-Seq_HELA_Human1.21493712
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19547486
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18970131
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18545242
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17924024
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17466323
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16741752
70KDM5A_27292631_Chip-Seq_BREAST_Human1.15214762
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15131004
72EZH2_22144423_ChIP-Seq_EOC_Human1.13817967
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.13310653
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.12848930
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12714644
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12575673
77GABP_19822575_ChIP-Seq_HepG2_Human1.12191472
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12143463
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09564022
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08031255
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.07779621
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.07775790
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06670445
84P300_19829295_ChIP-Seq_ESCs_Human1.05054174
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04064099
86RNF2_27304074_Chip-Seq_NSC_Mouse1.03973809
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01822819
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01042222
89IGF1R_20145208_ChIP-Seq_DFB_Human0.99938098
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97460728
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97086582
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96596464
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96129378
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96080906
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95739575
96ZNF274_21170338_ChIP-Seq_K562_Hela0.95063866
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94768312
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94702060
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93460777
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93048689
101P300_18555785_Chip-Seq_ESCs_Mouse0.92492338
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92489145
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91108902
104TAL1_26923725_Chip-Seq_HPCs_Mouse0.91048528
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90679115
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90602035
107STAT3_18555785_Chip-Seq_ESCs_Mouse0.90592833
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89880970
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.89125146
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88332393
111HTT_18923047_ChIP-ChIP_STHdh_Human0.88058182
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.87074951
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.86626913
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85929344
115JUN_21703547_ChIP-Seq_K562_Human0.85416287
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84181276
117P53_22387025_ChIP-Seq_ESCs_Mouse0.83381041
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.80662291
119RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80186152
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80096690
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.79863779
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.79388910
123SOX2_18555785_Chip-Seq_ESCs_Mouse0.78789296
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.78310956
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78105992
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78089053
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78052098
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77103898
129ELF5_23300383_ChIP-Seq_T47D_Human0.76953084
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76077184
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75244372
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74744333
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72084938
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70273458
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69993900
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69720537
137TP53_22573176_ChIP-Seq_HFKS_Human0.69031552
138TFEB_21752829_ChIP-Seq_HELA_Human0.68699798
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67383857
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67060605
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66979540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.47323286
2MP0003880_abnormal_central_pattern3.86670943
3MP0009379_abnormal_foot_pigmentation3.12320707
4MP0001905_abnormal_dopamine_level3.08984326
5MP0000920_abnormal_myelination3.08630107
6MP0003136_yellow_coat_color2.89038598
7MP0003111_abnormal_nucleus_morphology2.57007708
8MP0005409_darkened_coat_color2.29362719
9MP0004142_abnormal_muscle_tone2.26638349
10MP0000566_synostosis2.26546030
11MP0003941_abnormal_skin_development2.23479623
12MP0008057_abnormal_DNA_replication2.13839041
13MP0008877_abnormal_DNA_methylation2.06971865
14MP0002102_abnormal_ear_morphology2.05028212
15MP0008007_abnormal_cellular_replicative1.99776674
16MP0006276_abnormal_autonomic_nervous1.98861817
17MP0005410_abnormal_fertilization1.96653674
18MP0006072_abnormal_retinal_apoptosis1.93896319
19MP0008932_abnormal_embryonic_tissue1.92528449
20MP0003806_abnormal_nucleotide_metabolis1.89788992
21MP0001485_abnormal_pinna_reflex1.89044275
22MP0002272_abnormal_nervous_system1.86817088
23MP0003950_abnormal_plasma_membrane1.85395854
24MP0005171_absent_coat_pigmentation1.80372085
25MP0004742_abnormal_vestibular_system1.80107577
26MP0002837_dystrophic_cardiac_calcinosis1.78264164
27MP0003718_maternal_effect1.73225624
28MP0001486_abnormal_startle_reflex1.72283772
29MP0006036_abnormal_mitochondrial_physio1.67860138
30MP0001293_anophthalmia1.67046026
31MP0008789_abnormal_olfactory_epithelium1.64682019
32MP0002736_abnormal_nociception_after1.63320075
33MP0004270_analgesia1.62759577
34MP0001986_abnormal_taste_sensitivity1.61229927
35MP0000778_abnormal_nervous_system1.56856261
36MP0005423_abnormal_somatic_nervous1.56204934
37MP0005084_abnormal_gallbladder_morpholo1.51913097
38MP0002163_abnormal_gland_morphology1.49266965
39MP0006292_abnormal_olfactory_placode1.47567509
40MP0002160_abnormal_reproductive_system1.47019083
41MP0005451_abnormal_body_composition1.46070812
42MP0002064_seizures1.40863445
43MP0002234_abnormal_pharynx_morphology1.40481935
44MP0001188_hyperpigmentation1.39406158
45MP0001968_abnormal_touch/_nociception1.39080350
46MP0004381_abnormal_hair_follicle1.36642481
47MP0010030_abnormal_orbit_morphology1.33794187
48MP0002734_abnormal_mechanical_nocicepti1.33385048
49MP0003938_abnormal_ear_development1.30516467
50MP0003567_abnormal_fetal_cardiomyocyte1.28725232
51MP0009745_abnormal_behavioral_response1.28604918
52MP0008058_abnormal_DNA_repair1.27518771
53MP0001963_abnormal_hearing_physiology1.24700544
54MP0004957_abnormal_blastocyst_morpholog1.24587491
55MP0002735_abnormal_chemical_nociception1.23192717
56MP0009046_muscle_twitch1.22438335
57MP0006035_abnormal_mitochondrial_morpho1.22331927
58MP0008260_abnormal_autophagy1.21895185
59MP0004147_increased_porphyrin_level1.20970487
60MP0003186_abnormal_redox_activity1.20745252
61MP0010094_abnormal_chromosome_stability1.20630585
62MP0000358_abnormal_cell_content/1.18681424
63MP0004134_abnormal_chest_morphology1.15753586
64MP0000049_abnormal_middle_ear1.15186348
65MP0005408_hypopigmentation1.15161929
66MP0000372_irregular_coat_pigmentation1.14902626
67MP0001764_abnormal_homeostasis1.14235719
68MP0002229_neurodegeneration1.12198584
69MP0003634_abnormal_glial_cell1.10171999
70MP0009697_abnormal_copulation1.09662971
71MP0003315_abnormal_perineum_morphology1.08970341
72MP0005551_abnormal_eye_electrophysiolog1.08894014
73MP0002752_abnormal_somatic_nervous1.08211322
74MP0001984_abnormal_olfaction1.08154651
75MP0001970_abnormal_pain_threshold1.07817691
76MP0002572_abnormal_emotion/affect_behav1.07769645
77MP0000026_abnormal_inner_ear1.07216168
78MP0003123_paternal_imprinting1.06922262
79MP0005379_endocrine/exocrine_gland_phen1.06070872
80MP0000462_abnormal_digestive_system1.05649654
81MP0002638_abnormal_pupillary_reflex1.05593223
82MP0005386_behavior/neurological_phenoty1.05551956
83MP0004924_abnormal_behavior1.05551956
84MP0002067_abnormal_sensory_capabilities1.04656955
85MP0001440_abnormal_grooming_behavior1.04368634
86MP0000350_abnormal_cell_proliferation1.03915167
87MP0002938_white_spotting1.02939018
88MP0002233_abnormal_nose_morphology1.01929066
89MP0003698_abnormal_male_reproductive1.01148170
90MP0001929_abnormal_gametogenesis1.00899439
91MP0001286_abnormal_eye_development0.99859837
92MP0005389_reproductive_system_phenotype0.98476928
93MP0002210_abnormal_sex_determination0.97967287
94MP0002090_abnormal_vision0.97380247
95MP0003937_abnormal_limbs/digits/tail_de0.97326326
96MP0005332_abnormal_amino_acid0.96744942
97MP0003693_abnormal_embryo_hatching0.95453346
98MP0002697_abnormal_eye_size0.94440474
99MP0002751_abnormal_autonomic_nervous0.94344358
100MP0001697_abnormal_embryo_size0.93074233
101MP0008995_early_reproductive_senescence0.92410888
102MP0001727_abnormal_embryo_implantation0.92203688
103MP0002882_abnormal_neuron_morphology0.91892486
104MP0005499_abnormal_olfactory_system0.91411117
105MP0005394_taste/olfaction_phenotype0.91411117
106MP0001730_embryonic_growth_arrest0.88082906
107MP0003635_abnormal_synaptic_transmissio0.87563918
108MP0004145_abnormal_muscle_electrophysio0.86924784
109MP0003786_premature_aging0.86764217
110MP0000749_muscle_degeneration0.86705415
111MP0002066_abnormal_motor_capabilities/c0.85875768
112MP0009250_abnormal_appendicular_skeleto0.85764723
113MP0005253_abnormal_eye_physiology0.85642827
114MP0001881_abnormal_mammary_gland0.85613213
115MP0000647_abnormal_sebaceous_gland0.84521178
116MP0003632_abnormal_nervous_system0.84422374
117MP0003121_genomic_imprinting0.84153689
118MP0004215_abnormal_myocardial_fiber0.83752413
119MP0000631_abnormal_neuroendocrine_gland0.80689214
120MP0003077_abnormal_cell_cycle0.80381818
121MP0001299_abnormal_eye_distance/0.79420058
122MP0002085_abnormal_embryonic_tissue0.79073086
123MP0003011_delayed_dark_adaptation0.78996848
124MP0002733_abnormal_thermal_nociception0.78525569
125MP0003787_abnormal_imprinting0.78509306
126MP0003690_abnormal_glial_cell0.78431644
127MP0003755_abnormal_palate_morphology0.77474301
128MP0001145_abnormal_male_reproductive0.77133095
129MP0002277_abnormal_respiratory_mucosa0.77123057
130MP0005645_abnormal_hypothalamus_physiol0.76865612
131MP0000653_abnormal_sex_gland0.74708321
132MP0003137_abnormal_impulse_conducting0.74645793
133MP0000955_abnormal_spinal_cord0.73948943
134MP0003122_maternal_imprinting0.73907929
135MP0002177_abnormal_outer_ear0.73802111
136MP0005195_abnormal_posterior_eye0.73150107
137MP0001348_abnormal_lacrimal_gland0.73014385
138MP0000762_abnormal_tongue_morphology0.71861089
139MP0000313_abnormal_cell_death0.69322954
140MP0003195_calcinosis0.68913426
141MP0005395_other_phenotype0.66109478
142MP0002084_abnormal_developmental_patter0.65093228
143MP0005391_vision/eye_phenotype0.65030340
144MP0002184_abnormal_innervation0.64892337
145MP0002080_prenatal_lethality0.64890649
146MP0005266_abnormal_metabolism0.62694955
147MP0002111_abnormal_tail_morphology0.62200921
148MP0001542_abnormal_bone_strength0.61888694

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)5.60656571
2* Mitochondrial inheritance (HP:0001427)5.12421165
3* Abnormal mitochondria in muscle tissue (HP:0008316)4.88807918
4Increased hepatocellular lipid droplets (HP:0006565)4.83095945
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.66933314
6* Progressive macrocephaly (HP:0004481)4.61480731
7* Acute encephalopathy (HP:0006846)4.51404640
8Renal Fanconi syndrome (HP:0001994)4.40115740
9Abnormality of glycolysis (HP:0004366)4.40002455
10Increased serum pyruvate (HP:0003542)4.40002455
11* Increased CSF lactate (HP:0002490)4.30629084
12Lipid accumulation in hepatocytes (HP:0006561)4.26021406
13* Hepatocellular necrosis (HP:0001404)4.21667506
14Parakeratosis (HP:0001036)4.12808246
153-Methylglutaconic aciduria (HP:0003535)3.94035074
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.93867817
17* Leukodystrophy (HP:0002415)3.64232049
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64119987
19Sensory axonal neuropathy (HP:0003390)3.63251801
20Cerebral hypomyelination (HP:0006808)3.50944949
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.43090791
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.43090791
23Increased intramyocellular lipid droplets (HP:0012240)3.36246355
24Exertional dyspnea (HP:0002875)3.36189627
25* Hepatic necrosis (HP:0002605)3.35868651
26Congenital ichthyosiform erythroderma (HP:0007431)3.15021125
27* Respiratory failure (HP:0002878)3.06458396
28* Increased serum lactate (HP:0002151)2.91422807
29* Optic disc pallor (HP:0000543)2.90488038
30* Cerebral edema (HP:0002181)2.85103345
31* Exercise intolerance (HP:0003546)2.83087113
32Abnormality of renal resorption (HP:0011038)2.82617006
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80680119
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80680119
35Abnormality of cells of the erythroid lineage (HP:0012130)2.76203309
36Colon cancer (HP:0003003)2.72296584
37Respiratory difficulties (HP:0002880)2.71599239
38Increased muscle lipid content (HP:0009058)2.69209494
39* Lactic acidosis (HP:0003128)2.65266262
40Reticulocytopenia (HP:0001896)2.56251480
41Abnormality of methionine metabolism (HP:0010901)2.54232902
42Abnormal number of erythroid precursors (HP:0012131)2.50403342
43Retinal dysplasia (HP:0007973)2.49847982
44Aplastic anemia (HP:0001915)2.45884968
45Hypoplastic pelvis (HP:0008839)2.39243655
46Medial flaring of the eyebrow (HP:0010747)2.38383390
47Oral leukoplakia (HP:0002745)2.35535281
48* Lethargy (HP:0001254)2.35451012
49Abnormality of the anterior horn cell (HP:0006802)2.31523128
50Degeneration of anterior horn cells (HP:0002398)2.31523128
51Type I transferrin isoform profile (HP:0003642)2.31245998
52Congenital, generalized hypertrichosis (HP:0004540)2.29859995
53Irregular epiphyses (HP:0010582)2.26892511
54Macrocytic anemia (HP:0001972)2.26606328
55Meckel diverticulum (HP:0002245)2.23787840
56Abnormality of the corticospinal tract (HP:0002492)2.22894634
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22420738
58Abnormality of alanine metabolism (HP:0010916)2.22420738
59Hyperalaninemia (HP:0003348)2.22420738
60Adrenal hypoplasia (HP:0000835)2.21814958
61Duplicated collecting system (HP:0000081)2.20948401
62Peripheral hypomyelination (HP:0007182)2.20310567
63Amniotic constriction ring (HP:0009775)2.19834223
64Abnormality of placental membranes (HP:0011409)2.19834223
65Chromsome breakage (HP:0040012)2.18415801
66Vaginal atresia (HP:0000148)2.17994261
67Neuroendocrine neoplasm (HP:0100634)2.13841377
68Genital tract atresia (HP:0001827)2.12418576
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12284480
70Abnormality of the ileum (HP:0001549)2.10601237
71Gait imbalance (HP:0002141)2.10081061
72Microvesicular hepatic steatosis (HP:0001414)2.08488525
73Methylmalonic acidemia (HP:0002912)2.07744940
74Stenosis of the external auditory canal (HP:0000402)2.07504942
75Absent thumb (HP:0009777)2.06800691
76Congenital primary aphakia (HP:0007707)2.06729833
77Pheochromocytoma (HP:0002666)2.06690048
78Hypoglycemic coma (HP:0001325)2.06203207
79Spastic paraparesis (HP:0002313)2.03645410
80Neurofibrillary tangles (HP:0002185)2.03543242
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02747650
82CNS hypomyelination (HP:0003429)2.02095419
83Abnormality of serum amino acid levels (HP:0003112)2.01035775
84Absent septum pellucidum (HP:0001331)2.00978745
85Hyperglycinemia (HP:0002154)2.00701344
86Pancytopenia (HP:0001876)2.00317394
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.98904354
88Abnormality of the septum pellucidum (HP:0007375)1.98155540
89Myokymia (HP:0002411)1.97880647
90Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97791857
91Abnormal protein glycosylation (HP:0012346)1.97042128
92Abnormal glycosylation (HP:0012345)1.97042128
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97042128
94Abnormal protein N-linked glycosylation (HP:0012347)1.97042128
95Generalized aminoaciduria (HP:0002909)1.96906419
96Megaloblastic anemia (HP:0001889)1.96893363
97Nephrogenic diabetes insipidus (HP:0009806)1.94559397
98Abnormality of the preputium (HP:0100587)1.93953836
99Molar tooth sign on MRI (HP:0002419)1.89776039
100Abnormality of midbrain morphology (HP:0002418)1.89776039
101Cerebral hemorrhage (HP:0001342)1.89208634
102Reduced antithrombin III activity (HP:0001976)1.89066385
103Sparse eyelashes (HP:0000653)1.88748408
104Pancreatic cysts (HP:0001737)1.87794497
105Abnormality of the renal collecting system (HP:0004742)1.87246811
106Birth length less than 3rd percentile (HP:0003561)1.86304204
107Autoamputation (HP:0001218)1.85076702
108Duplication of thumb phalanx (HP:0009942)1.83281743
109* CNS demyelination (HP:0007305)1.83269205
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.82858171
111Absent/shortened dynein arms (HP:0200106)1.82858171
112Abnormality of chromosome stability (HP:0003220)1.82395847
113* X-linked dominant inheritance (HP:0001423)1.81979268
114Abnormal ciliary motility (HP:0012262)1.80999611
115Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79979516
116Pancreatic fibrosis (HP:0100732)1.79045980
117Breast hypoplasia (HP:0003187)1.78565882
118Hyperphosphaturia (HP:0003109)1.76348773
119Cleft eyelid (HP:0000625)1.75710645
120Pallor (HP:0000980)1.72584367
121Abnormality of urine glucose concentration (HP:0011016)1.72079112
122Glycosuria (HP:0003076)1.72079112
123* Emotional lability (HP:0000712)1.71138227
124Multiple enchondromatosis (HP:0005701)1.71002172
125Horseshoe kidney (HP:0000085)1.70725096
126Triphalangeal thumb (HP:0001199)1.70305587
127Testicular atrophy (HP:0000029)1.69582270
128Abnormal hair whorl (HP:0010721)1.69342975
129Hypoplastic left heart (HP:0004383)1.68438069
130Delusions (HP:0000746)1.68121291
131Methylmalonic aciduria (HP:0012120)1.67352930
132Abnormal number of incisors (HP:0011064)1.67247825
133Nasolacrimal duct obstruction (HP:0000579)1.66164619
134Erythroderma (HP:0001019)1.65546357
135Hepatosplenomegaly (HP:0001433)1.64805730
136Poor suck (HP:0002033)1.63432532
137Rough bone trabeculation (HP:0100670)1.62744753
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.62199961
139Nephronophthisis (HP:0000090)1.61586502
140Septo-optic dysplasia (HP:0100842)1.60673215
141* Blindness (HP:0000618)1.60504996
142Abnormality of the labia minora (HP:0012880)1.60371160
143Abnormal respiratory motile cilium morphology (HP:0005938)1.59928056
144Abnormal respiratory epithelium morphology (HP:0012253)1.59928056
145Absent epiphyses (HP:0010577)1.59602379
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59602379
147Abnormal lung lobation (HP:0002101)1.59324736
148Hyperinsulinemic hypoglycemia (HP:0000825)1.59224163
149Alacrima (HP:0000522)1.58961372
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55878288
151Cupped ear (HP:0000378)1.55724682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.67063487
2VRK24.64150098
3OXSR13.14027922
4PBK3.05713647
5NEK12.74018186
6MST42.71282570
7TNIK2.48715667
8STK162.42422337
9BCR2.40196199
10CASK2.40128073
11EIF2AK12.31720758
12NME12.18681771
13BUB12.12138676
14NME22.05665104
15CDK192.05658245
16TLK11.98950063
17ZAK1.90969831
18PNCK1.85486747
19MAPKAPK51.81938638
20WNK41.81202921
21MKNK11.77031528
22ARAF1.74438691
23TRIM281.74214003
24MUSK1.73725484
25VRK11.66842655
26PDK21.64626025
27WEE11.57874731
28LIMK11.55960238
29PKN11.50500932
30TAF11.50494686
31NEK61.39683471
32DYRK21.37414322
33EIF2AK31.34723803
34CSNK1G31.31149815
35SRPK11.30981906
36BMPR1B1.30460534
37UHMK11.30044415
38GRK71.20918431
39EPHB11.17205513
40IRAK21.12359510
41MAP4K21.11899374
42PLK41.10653878
43PLK21.09222574
44MKNK21.08006702
45MAP2K71.07675530
46AURKB1.05753278
47BRAF1.03470736
48MAPK131.02067469
49ADRBK21.01403883
50MAP3K120.93494185
51CAMK2B0.92520230
52CDC70.92138634
53ATR0.87346781
54PASK0.86016567
55GRK50.85263790
56BCKDK0.84854837
57GRK10.83349086
58TESK20.82441111
59PIM20.82125143
60DYRK30.81743090
61BRSK20.81533972
62PHKG20.81145744
63PHKG10.81145744
64CLK10.80997144
65CSNK1G10.79683211
66ROCK20.77811730
67ABL20.77766966
68FGR0.76579064
69RPS6KA40.75279412
70IRAK10.75250536
71CAMK2D0.74304215
72CSNK1A1L0.73839010
73MET0.73612430
74PLK30.72503683
75BRSK10.72245214
76RPS6KA50.71923914
77CSNK1G20.71069434
78TSSK60.70956675
79CDK80.69711495
80NEK20.69217704
81CDK140.69124988
82BMPR20.68357811
83STK40.68285388
84CAMK2A0.65628143
85CCNB10.64875414
86ILK0.63704553
87CSNK1E0.62300470
88ERBB30.61979094
89CHEK10.61550768
90ACVR1B0.61454244
91AURKA0.61406512
92CDK180.61137560
93DAPK10.60544410
94ATM0.59086299
95CDK150.58799649
96PRKCG0.58737442
97CAMK2G0.58127153
98PINK10.58036120
99CDK11A0.57930175
100CHEK20.56426952
101MYLK0.56042324
102PRKCI0.55553585
103STK38L0.54535215
104YES10.54292260
105MARK10.53344986
106MAP3K60.53103806
107FRK0.51356662
108PAK40.51339281
109STK30.50137786
110PLK10.48832899
111OBSCN0.47968914
112IRAK40.47654459
113MINK10.47549686
114DAPK30.47455159
115CSNK2A20.47324997
116TTK0.46744538
117PAK10.46092202
118WNK10.45736459
119CSNK2A10.44622182
120CDK30.42963774
121CDK70.41527922
122PRKCE0.41411864
123ERBB40.41112375
124TESK10.40166769
125PRPF4B0.39662719
126INSRR0.39426208
127IRAK30.38966453
128EIF2AK20.38845261
129RPS6KB20.37478500
130SCYL20.35638791
131ADRBK10.35458382
132MAP3K40.35408749
133PRKCQ0.34683144
134TIE10.33718575
135PIK3CG0.33518809
136WNK30.32799872
137PRKACA0.31094473
138SGK4940.26610989
139SGK2230.26610989
140NUAK10.26422180

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.03204963
2Parkinsons disease_Homo sapiens_hsa050124.28414860
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.84685958
4Ribosome_Homo sapiens_hsa030103.78496622
5Proteasome_Homo sapiens_hsa030503.49608564
6RNA polymerase_Homo sapiens_hsa030203.26656713
7Alzheimers disease_Homo sapiens_hsa050103.19664519
8Huntingtons disease_Homo sapiens_hsa050163.15906961
9Protein export_Homo sapiens_hsa030603.06873620
10Steroid biosynthesis_Homo sapiens_hsa001002.90535194
11Fatty acid elongation_Homo sapiens_hsa000622.61710328
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51897355
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43061831
14One carbon pool by folate_Homo sapiens_hsa006701.89441900
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88897604
16Homologous recombination_Homo sapiens_hsa034401.85544061
17DNA replication_Homo sapiens_hsa030301.79958503
18Mismatch repair_Homo sapiens_hsa034301.79852475
19Cardiac muscle contraction_Homo sapiens_hsa042601.79096609
20Basal transcription factors_Homo sapiens_hsa030221.78232581
21Ether lipid metabolism_Homo sapiens_hsa005651.77510331
22Pyrimidine metabolism_Homo sapiens_hsa002401.65949220
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64708838
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61418411
25Nucleotide excision repair_Homo sapiens_hsa034201.54181659
26Spliceosome_Homo sapiens_hsa030401.52947715
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40559181
28Vitamin B6 metabolism_Homo sapiens_hsa007501.29435483
29Non-homologous end-joining_Homo sapiens_hsa034501.16737083
30Fanconi anemia pathway_Homo sapiens_hsa034601.13817012
31Collecting duct acid secretion_Homo sapiens_hsa049661.12799347
32Linoleic acid metabolism_Homo sapiens_hsa005911.11944319
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11325520
34Purine metabolism_Homo sapiens_hsa002301.09498073
35RNA degradation_Homo sapiens_hsa030181.07679639
36Sulfur metabolism_Homo sapiens_hsa009201.05827581
37Glutathione metabolism_Homo sapiens_hsa004801.00912979
38RNA transport_Homo sapiens_hsa030130.99012480
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98025174
40Arachidonic acid metabolism_Homo sapiens_hsa005900.97007214
41Sphingolipid metabolism_Homo sapiens_hsa006000.96257689
42Selenocompound metabolism_Homo sapiens_hsa004500.90950645
43Metabolic pathways_Homo sapiens_hsa011000.84602166
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84478077
45Sulfur relay system_Homo sapiens_hsa041220.83569255
46Vibrio cholerae infection_Homo sapiens_hsa051100.83217465
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83100941
48Base excision repair_Homo sapiens_hsa034100.82291196
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78975636
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77231087
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74269273
52Serotonergic synapse_Homo sapiens_hsa047260.70823592
53Cell cycle_Homo sapiens_hsa041100.64917454
54Arginine and proline metabolism_Homo sapiens_hsa003300.63070511
55Pyruvate metabolism_Homo sapiens_hsa006200.61796850
56Biosynthesis of amino acids_Homo sapiens_hsa012300.61210316
57Propanoate metabolism_Homo sapiens_hsa006400.60844426
58Histidine metabolism_Homo sapiens_hsa003400.58099649
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56906686
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56110574
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53707486
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52473706
63Folate biosynthesis_Homo sapiens_hsa007900.51103649
64p53 signaling pathway_Homo sapiens_hsa041150.50036862
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49997463
66Phototransduction_Homo sapiens_hsa047440.49712051
67Rheumatoid arthritis_Homo sapiens_hsa053230.48991900
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.48334171
69Nicotine addiction_Homo sapiens_hsa050330.48000169
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47843822
71Axon guidance_Homo sapiens_hsa043600.45017692
72beta-Alanine metabolism_Homo sapiens_hsa004100.43146049
73Butanoate metabolism_Homo sapiens_hsa006500.43134664
74Fatty acid degradation_Homo sapiens_hsa000710.42151697
75Fatty acid metabolism_Homo sapiens_hsa012120.42014490
76Autoimmune thyroid disease_Homo sapiens_hsa053200.41283671
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40804223
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40157579
79Tryptophan metabolism_Homo sapiens_hsa003800.40043534
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39874164
81N-Glycan biosynthesis_Homo sapiens_hsa005100.39300493
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.37680920
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.36492197
84Phagosome_Homo sapiens_hsa041450.34094666
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33901806
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33294976
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32971840
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31904322
89Epstein-Barr virus infection_Homo sapiens_hsa051690.31344354
90Peroxisome_Homo sapiens_hsa041460.31266317
91mRNA surveillance pathway_Homo sapiens_hsa030150.31248908
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30977008
93Tyrosine metabolism_Homo sapiens_hsa003500.30665805
94Oocyte meiosis_Homo sapiens_hsa041140.27288247
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26840071
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26620902
97Long-term depression_Homo sapiens_hsa047300.25615432
98Vitamin digestion and absorption_Homo sapiens_hsa049770.25123561
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25101888
100Alcoholism_Homo sapiens_hsa050340.24449602
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24331524
102Systemic lupus erythematosus_Homo sapiens_hsa053220.23564000
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22944585
104Glutamatergic synapse_Homo sapiens_hsa047240.20002743
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.19648426
106GABAergic synapse_Homo sapiens_hsa047270.17626907
107Regulation of autophagy_Homo sapiens_hsa041400.16514249
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.14891636
109Mineral absorption_Homo sapiens_hsa049780.13369869
110Nitrogen metabolism_Homo sapiens_hsa009100.13321991
111Hedgehog signaling pathway_Homo sapiens_hsa043400.13269672
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13036164
113Basal cell carcinoma_Homo sapiens_hsa052170.12957735
114Chemical carcinogenesis_Homo sapiens_hsa052040.11797950
115Taste transduction_Homo sapiens_hsa047420.10443295
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09940456
117Fat digestion and absorption_Homo sapiens_hsa049750.09634464
118Morphine addiction_Homo sapiens_hsa050320.09289818
119Arginine biosynthesis_Homo sapiens_hsa002200.08497365
120Synaptic vesicle cycle_Homo sapiens_hsa047210.08461140
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08388844
122Asthma_Homo sapiens_hsa053100.07295259
123Tight junction_Homo sapiens_hsa045300.05858423
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05421141
125Retinol metabolism_Homo sapiens_hsa008300.04827978
126Ovarian steroidogenesis_Homo sapiens_hsa049130.04564194
127Ras signaling pathway_Homo sapiens_hsa040140.04227983
128Allograft rejection_Homo sapiens_hsa053300.03476172
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02678851
130Pentose phosphate pathway_Homo sapiens_hsa000300.02448491
131Carbon metabolism_Homo sapiens_hsa012000.02144367

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