NDUFAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory chain complex IV assembly (GO:0008535)4.98363783
2oxidative phosphorylation (GO:0006119)4.90834940
3regulation of glucokinase activity (GO:0033131)4.54159988
4regulation of hexokinase activity (GO:1903299)4.54159988
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.47319391
6L-phenylalanine metabolic process (GO:0006558)4.47319391
7glycine metabolic process (GO:0006544)4.43102029
8L-phenylalanine catabolic process (GO:0006559)4.41300737
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.41300737
10water-soluble vitamin biosynthetic process (GO:0042364)4.40684805
11cytochrome complex assembly (GO:0017004)4.36729750
12lysine catabolic process (GO:0006554)4.29487263
13lysine metabolic process (GO:0006553)4.29487263
14protein neddylation (GO:0045116)4.28679464
15tricarboxylic acid cycle (GO:0006099)4.24548442
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.18632094
17inner mitochondrial membrane organization (GO:0007007)4.16863712
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.14894604
19fructose metabolic process (GO:0006000)4.08498013
20chaperone-mediated protein transport (GO:0072321)4.02282189
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00147927
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99126416
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.99126416
24NADH dehydrogenase complex assembly (GO:0010257)3.99126416
25aromatic amino acid family catabolic process (GO:0009074)3.98056129
26serine family amino acid catabolic process (GO:0009071)3.82313335
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81393225
28NADH metabolic process (GO:0006734)3.80580494
29glyoxylate metabolic process (GO:0046487)3.79865252
30peptidyl-histidine modification (GO:0018202)3.79266318
31serine family amino acid biosynthetic process (GO:0009070)3.78120663
32succinate metabolic process (GO:0006105)3.76577284
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.74705249
34branched-chain amino acid catabolic process (GO:0009083)3.74464626
35protein deneddylation (GO:0000338)3.73394833
36protein complex biogenesis (GO:0070271)3.70156424
37serine family amino acid metabolic process (GO:0009069)3.68934825
38L-methionine salvage (GO:0071267)3.66247438
39L-methionine biosynthetic process (GO:0071265)3.66247438
40amino acid salvage (GO:0043102)3.66247438
41mitochondrial respiratory chain complex assembly (GO:0033108)3.66042742
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65438090
43ATP synthesis coupled proton transport (GO:0015986)3.65438090
44termination of RNA polymerase III transcription (GO:0006386)3.64550987
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.64550987
46regulation of acyl-CoA biosynthetic process (GO:0050812)3.62630420
47bile acid biosynthetic process (GO:0006699)3.61991735
48cysteine metabolic process (GO:0006534)3.61618969
492-oxoglutarate metabolic process (GO:0006103)3.60878904
50indole-containing compound catabolic process (GO:0042436)3.59282258
51indolalkylamine catabolic process (GO:0046218)3.59282258
52tryptophan catabolic process (GO:0006569)3.59282258
53oxaloacetate metabolic process (GO:0006107)3.59104236
54DNA deamination (GO:0045006)3.58365273
55lactate metabolic process (GO:0006089)3.57427533
56regulation of coenzyme metabolic process (GO:0051196)3.56574041
57regulation of cofactor metabolic process (GO:0051193)3.56574041
58* respiratory electron transport chain (GO:0022904)3.56167873
59regulation of mitochondrial translation (GO:0070129)3.49721508
60* electron transport chain (GO:0022900)3.46184936
61ribosomal small subunit assembly (GO:0000028)3.44443082
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40580059
63ubiquinone metabolic process (GO:0006743)3.40154201
64homocysteine metabolic process (GO:0050667)3.38712470
65protein-cofactor linkage (GO:0018065)3.38427223
66* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38197068
67L-serine metabolic process (GO:0006563)3.37871559
68NAD metabolic process (GO:0019674)3.37440342
69tryptophan metabolic process (GO:0006568)3.37317990
70aspartate family amino acid catabolic process (GO:0009068)3.37086768
71ketone body metabolic process (GO:1902224)3.34319226
72alpha-amino acid catabolic process (GO:1901606)3.33984305
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33313686
74branched-chain amino acid metabolic process (GO:0009081)3.33294993
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30819098
76kynurenine metabolic process (GO:0070189)3.29661764
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28917677
78negative regulation of ligase activity (GO:0051352)3.19844263
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19844263
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18828000
81imidazole-containing compound metabolic process (GO:0052803)3.17254790
82proteasome assembly (GO:0043248)3.16901756
83triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15844937
84mannosylation (GO:0097502)3.15421262
85coenzyme catabolic process (GO:0009109)3.14255395
86NAD biosynthetic process (GO:0009435)3.13118323
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12970788
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12970788
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11741994
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11741994
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11741994
92cellular ketone body metabolic process (GO:0046950)3.10169239
93cellular amino acid catabolic process (GO:0009063)3.08690869
94protein targeting to mitochondrion (GO:0006626)3.08263036
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08167030
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08167030
97aldehyde catabolic process (GO:0046185)3.07660678
98amino-acid betaine metabolic process (GO:0006577)3.06916658
99platelet dense granule organization (GO:0060155)3.04093243
100negative regulation of fibrinolysis (GO:0051918)3.02339630
101pseudouridine synthesis (GO:0001522)3.00580936
102aerobic respiration (GO:0009060)2.99655968
103short-chain fatty acid metabolic process (GO:0046459)2.99648472
104sulfur amino acid catabolic process (GO:0000098)2.98936816
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98457729
106hydrogen ion transmembrane transport (GO:1902600)2.98048895
107aromatic amino acid family metabolic process (GO:0009072)2.97675551
108pyridine nucleotide biosynthetic process (GO:0019363)2.95924257
109nicotinamide nucleotide biosynthetic process (GO:0019359)2.95924257
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.95523517
111acetyl-CoA metabolic process (GO:0006084)2.94883075
112transcription from mitochondrial promoter (GO:0006390)2.94456698
113metallo-sulfur cluster assembly (GO:0031163)2.94445027
114iron-sulfur cluster assembly (GO:0016226)2.94445027
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93081980
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.93081980
117establishment of protein localization to mitochondrion (GO:0072655)2.93002824
118intracellular protein transmembrane import (GO:0044743)2.91807803
119ATP biosynthetic process (GO:0006754)2.90998768
120cofactor catabolic process (GO:0051187)2.90900273
121ubiquinone biosynthetic process (GO:0006744)2.90874555
122quinone biosynthetic process (GO:1901663)2.90874555
123fatty acid beta-oxidation (GO:0006635)2.90568364
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87320950
125lipopolysaccharide biosynthetic process (GO:0009103)2.87064013
126protein localization to mitochondrion (GO:0070585)2.86979647
127folic acid metabolic process (GO:0046655)2.86613027
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86310294
129regulation of fibrinolysis (GO:0051917)2.86292573
130valine metabolic process (GO:0006573)2.85573039
131regulation of cellular amino acid metabolic process (GO:0006521)2.85417107
132urea metabolic process (GO:0019627)2.83745656
133urea cycle (GO:0000050)2.83745656
134dicarboxylic acid metabolic process (GO:0043648)2.83464668
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83119134
136purine nucleobase biosynthetic process (GO:0009113)2.80717445
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80690520
138ribosome biogenesis (GO:0042254)2.80463014
139regulation of sulfur metabolic process (GO:0042762)2.80265782
140cullin deneddylation (GO:0010388)2.79718866
141regulation of protein activation cascade (GO:2000257)2.79681911
142proton transport (GO:0015992)2.79492711
143positive regulation of ligase activity (GO:0051351)2.79177060
144organic acid catabolic process (GO:0016054)2.78053888
145carboxylic acid catabolic process (GO:0046395)2.78053888
146rRNA modification (GO:0000154)2.77890727
147DNA double-strand break processing (GO:0000729)2.77880088
148preassembly of GPI anchor in ER membrane (GO:0016254)2.77176621
149methionine biosynthetic process (GO:0009086)2.75213157
150hydrogen transport (GO:0006818)2.73815191
151purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73480589
152mitochondrial RNA metabolic process (GO:0000959)2.73083364
153ethanol oxidation (GO:0006069)2.71916750
154bile acid metabolic process (GO:0008206)2.71378262
155regulation of triglyceride catabolic process (GO:0010896)2.69861037
156S-adenosylmethionine metabolic process (GO:0046500)2.69538422
157anterograde synaptic vesicle transport (GO:0048490)2.68959367
158cellular respiration (GO:0045333)2.68591147
159protein K6-linked ubiquitination (GO:0085020)2.68487833
160piRNA metabolic process (GO:0034587)2.67302562
161regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66612925
162vitamin biosynthetic process (GO:0009110)2.64637890
163cellular response to zinc ion (GO:0071294)2.64191659
164tRNA processing (GO:0008033)2.63038656
165glucosamine-containing compound catabolic process (GO:1901072)2.60516525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02210951
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19722065
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.99066332
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88899788
5E2F7_22180533_ChIP-Seq_HELA_Human3.67864546
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61139929
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.50827597
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46447049
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.31355269
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.23821447
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.22865739
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.22096654
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08962702
14RXR_22158963_ChIP-Seq_LIVER_Mouse3.07462178
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.03133708
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02302397
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98340642
18ZNF274_21170338_ChIP-Seq_K562_Hela2.87835384
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76791907
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76268448
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74719746
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.54961136
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51856509
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37610915
25* VDR_23849224_ChIP-Seq_CD4+_Human2.29174841
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20974662
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18438369
28VDR_22108803_ChIP-Seq_LS180_Human2.16184011
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13430805
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.07343138
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06690212
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02135827
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01232150
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01061524
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98699757
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.95093176
37GABP_19822575_ChIP-Seq_HepG2_Human1.94337907
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91457391
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90484780
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89205180
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87408941
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87019069
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85990568
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80250597
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79349751
46DCP1A_22483619_ChIP-Seq_HELA_Human1.79276507
47XRN2_22483619_ChIP-Seq_HELA_Human1.77603536
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.77555985
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67584226
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66077163
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64557149
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64475177
53EWS_26573619_Chip-Seq_HEK293_Human1.63569839
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60508691
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60333867
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57619679
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.56638797
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56076930
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.55379202
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53836477
61FUS_26573619_Chip-Seq_HEK293_Human1.53321385
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52473921
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50374309
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45492578
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.44203537
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41706957
67P300_19829295_ChIP-Seq_ESCs_Human1.40428699
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38631794
69TP53_22573176_ChIP-Seq_HFKS_Human1.35240024
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34652500
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34283002
72IGF1R_20145208_ChIP-Seq_DFB_Human1.33904469
73* ELK1_19687146_ChIP-ChIP_HELA_Human1.33272620
74CIITA_25753668_ChIP-Seq_RAJI_Human1.31350017
75* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30667741
76TAF15_26573619_Chip-Seq_HEK293_Human1.29505938
77GBX2_23144817_ChIP-Seq_PC3_Human1.26142178
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25708977
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.24118980
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22960348
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22692814
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21995820
83IRF1_19129219_ChIP-ChIP_H3396_Human1.21488498
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21421351
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18915082
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.18588069
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17912555
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.16717752
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16717752
90MYC_18940864_ChIP-ChIP_HL60_Human1.16561263
91SOX2_19829295_ChIP-Seq_ESCs_Human1.14570100
92NANOG_19829295_ChIP-Seq_ESCs_Human1.14570100
93TTF2_22483619_ChIP-Seq_HELA_Human1.13683927
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12737224
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12161667
96* ELK1_22589737_ChIP-Seq_MCF10A_Human1.11723910
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11634877
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11495912
99ER_23166858_ChIP-Seq_MCF-7_Human1.11138300
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11041463
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10549342
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09980651
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.06715308
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06680455
105AR_20517297_ChIP-Seq_VCAP_Human1.05418258
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04291342
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04272433
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.04186764
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.01068295
110HTT_18923047_ChIP-ChIP_STHdh_Human0.99225881
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98332083
112BCAT_22108803_ChIP-Seq_LS180_Human0.97805456
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97209651
114AR_21909140_ChIP-Seq_LNCAP_Human0.96912953
115FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96897133
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96509957
117* NCOR_22424771_ChIP-Seq_293T_Human0.95617157
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93525809
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92684272
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92287668
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91955509
122CBP_20019798_ChIP-Seq_JUKART_Human0.91955509
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90666674
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90608276
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89135525
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87305841
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86071105
128* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85130788
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84346522
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83496536
131KDM5A_27292631_Chip-Seq_BREAST_Human0.82731998
132PHF8_20622853_ChIP-Seq_HELA_Human0.82727020
133RBPJ_21746931_ChIP-Seq_IB4_Human0.82706703
134TCF4_22108803_ChIP-Seq_LS180_Human0.81450402
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78762777
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78537578
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77757867
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77006589
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76250126
140* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76142639
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74713384
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74434477
143GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73420919
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.71885885
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71835813
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70716066
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68125503
148KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67432111
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.65529866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.99501409
2MP0002139_abnormal_hepatobiliary_system5.29433536
3MP0003806_abnormal_nucleotide_metabolis5.06354430
4MP0005085_abnormal_gallbladder_physiolo4.53349352
5MP0005365_abnormal_bile_salt4.18342287
6MP0008875_abnormal_xenobiotic_pharmacok3.86343291
7MP0006036_abnormal_mitochondrial_physio3.42147325
8MP0009697_abnormal_copulation3.16528633
9MP0002102_abnormal_ear_morphology2.91446545
10MP0001529_abnormal_vocalization2.71700460
11MP0006035_abnormal_mitochondrial_morpho2.55742100
12MP0003011_delayed_dark_adaptation2.55147932
13MP0003186_abnormal_redox_activity2.51841638
14MP0005332_abnormal_amino_acid2.51560953
15MP0008877_abnormal_DNA_methylation2.49088882
16MP0001764_abnormal_homeostasis2.41878802
17MP0003195_calcinosis2.35572075
18MP0004147_increased_porphyrin_level2.27394340
19MP0010329_abnormal_lipoprotein_level2.15150469
20MP0002163_abnormal_gland_morphology2.04926403
21MP0008057_abnormal_DNA_replication2.04846143
22MP0003646_muscle_fatigue2.03408897
23MP0001984_abnormal_olfaction2.02188446
24MP0002837_dystrophic_cardiac_calcinosis2.00022993
25MP0002736_abnormal_nociception_after1.91850984
26MP0000569_abnormal_digit_pigmentation1.84144559
27MP0000749_muscle_degeneration1.81958250
28MP0006072_abnormal_retinal_apoptosis1.78602852
29MP0005266_abnormal_metabolism1.78063793
30MP0005319_abnormal_enzyme/_coenzyme1.76831766
31MP0005083_abnormal_biliary_tract1.76749110
32MP0003191_abnormal_cellular_cholesterol1.76535253
33MP0002876_abnormal_thyroid_physiology1.74561365
34MP0005379_endocrine/exocrine_gland_phen1.71596696
35MP0005253_abnormal_eye_physiology1.66941429
36MP0001666_abnormal_nutrient_absorption1.64365351
37MP0003656_abnormal_erythrocyte_physiolo1.62109891
38MP0002938_white_spotting1.61775643
39MP0001968_abnormal_touch/_nociception1.61130842
40MP0005551_abnormal_eye_electrophysiolog1.60443432
41MP0009840_abnormal_foam_cell1.57876607
42MP0005645_abnormal_hypothalamus_physiol1.55513992
43MP0008789_abnormal_olfactory_epithelium1.54778905
44MP0003252_abnormal_bile_duct1.54321977
45MP0005584_abnormal_enzyme/coenzyme_acti1.52047100
46MP0005330_cardiomyopathy1.50323498
47MP0003693_abnormal_embryo_hatching1.47589813
48MP0005084_abnormal_gallbladder_morpholo1.44621195
49MP0000609_abnormal_liver_physiology1.43957675
50MP0009046_muscle_twitch1.43341007
51MP0004215_abnormal_myocardial_fiber1.43108753
52MP0005451_abnormal_body_composition1.37664663
53MP0004957_abnormal_blastocyst_morpholog1.35187364
54MP0006292_abnormal_olfactory_placode1.32645495
55MP0004019_abnormal_vitamin_homeostasis1.30393851
56MP0010386_abnormal_urinary_bladder1.26594524
57MP0001986_abnormal_taste_sensitivity1.26046741
58MP0003221_abnormal_cardiomyocyte_apopto1.25685257
59MP0002118_abnormal_lipid_homeostasis1.25081619
60MP0004036_abnormal_muscle_relaxation1.24623782
61MP0000372_irregular_coat_pigmentation1.23997508
62MP0004133_heterotaxia1.22003697
63MP0002090_abnormal_vision1.20596807
64MP0005376_homeostasis/metabolism_phenot1.20262549
65MP0002332_abnormal_exercise_endurance1.18665089
66MP0004084_abnormal_cardiac_muscle1.18487537
67MP0008058_abnormal_DNA_repair1.17406897
68MP0000647_abnormal_sebaceous_gland1.14750366
69MP0005670_abnormal_white_adipose1.14336126
70MP0000598_abnormal_liver_morphology1.11761041
71MP0003868_abnormal_feces_composition1.11558645
72MP0002638_abnormal_pupillary_reflex1.08183052
73MP0002269_muscular_atrophy1.04815097
74MP0009745_abnormal_behavioral_response1.03733616
75MP0010094_abnormal_chromosome_stability1.02993810
76MP0003718_maternal_effect1.02938206
77MP0003787_abnormal_imprinting1.02482628
78MP0003136_yellow_coat_color1.02388967
79MP0002277_abnormal_respiratory_mucosa1.02008157
80MP0000358_abnormal_cell_content/1.00887941
81MP0000427_abnormal_hair_cycle0.98978872
82MP0004130_abnormal_muscle_cell0.98353048
83MP0005636_abnormal_mineral_homeostasis0.97491614
84MP0002272_abnormal_nervous_system0.96075574
85MP0002132_abnormal_respiratory_system0.95234492
86MP0006276_abnormal_autonomic_nervous0.90374357
87MP0001853_heart_inflammation0.89067522
88MP0009643_abnormal_urine_homeostasis0.88275387
89MP0001324_abnormal_eye_pigmentation0.87264280
90MP0004924_abnormal_behavior0.87249816
91MP0005386_behavior/neurological_phenoty0.87249816
92MP0003880_abnormal_central_pattern0.86389498
93MP0001929_abnormal_gametogenesis0.85768465
94MP0005389_reproductive_system_phenotype0.85715765
95MP0002693_abnormal_pancreas_physiology0.85161101
96MP0000751_myopathy0.85148390
97MP0002234_abnormal_pharynx_morphology0.85105503
98MP0005647_abnormal_sex_gland0.84659422
99MP0001905_abnormal_dopamine_level0.84204014
100MP0004142_abnormal_muscle_tone0.83896266
101MP0003077_abnormal_cell_cycle0.82723221
102MP0008469_abnormal_protein_level0.82284993
103MP0008872_abnormal_physiological_respon0.81601112
104MP0001501_abnormal_sleep_pattern0.80909995
105MP0005394_taste/olfaction_phenotype0.80304318
106MP0005499_abnormal_olfactory_system0.80304318
107MP0004145_abnormal_muscle_electrophysio0.80224565
108MP0002210_abnormal_sex_determination0.80073468
109MP0001544_abnormal_cardiovascular_syste0.79621786
110MP0005385_cardiovascular_system_phenoty0.79621786
111MP0005410_abnormal_fertilization0.79513877
112MP0001293_anophthalmia0.79460269
113MP0002095_abnormal_skin_pigmentation0.79102090
114MP0008007_abnormal_cellular_replicative0.78497336
115MP0002160_abnormal_reproductive_system0.78267245
116MP0001485_abnormal_pinna_reflex0.77524576
117MP0003950_abnormal_plasma_membrane0.77224150
118MP0005397_hematopoietic_system_phenotyp0.76951356
119MP0001545_abnormal_hematopoietic_system0.76951356
120MP0005535_abnormal_body_temperature0.73636033
121MP0003943_abnormal_hepatobiliary_system0.73561484
122MP0005174_abnormal_tail_pigmentation0.73340582
123MP0002106_abnormal_muscle_physiology0.72475479
124MP0003121_genomic_imprinting0.71726961
125MP0002078_abnormal_glucose_homeostasis0.71530944
126MP0009763_increased_sensitivity_to0.71330671
127MP0002909_abnormal_adrenal_gland0.71222910
128MP0000653_abnormal_sex_gland0.71018810
129MP0005408_hypopigmentation0.70501301
130MP0005220_abnormal_exocrine_pancreas0.70392792
131MP0003137_abnormal_impulse_conducting0.69815292
132MP0008775_abnormal_heart_ventricle0.69748339
133MP0009642_abnormal_blood_homeostasis0.69096522
134MP0009379_abnormal_foot_pigmentation0.67452778
135MP0004043_abnormal_pH_regulation0.66630243
136MP0002971_abnormal_brown_adipose0.66345420
137MP0009764_decreased_sensitivity_to0.66191696
138MP0002127_abnormal_cardiovascular_syste0.64912335
139MP0000747_muscle_weakness0.64116756
140MP0000681_abnormal_thyroid_gland0.63983871
141MP0004808_abnormal_hematopoietic_stem0.61222188
142MP0003786_premature_aging0.60959129
143MP0003567_abnormal_fetal_cardiomyocyte0.60402719
144MP0002396_abnormal_hematopoietic_system0.59485480
145MP0008260_abnormal_autophagy0.57676892
146MP0008932_abnormal_embryonic_tissue0.57426830
147MP0000689_abnormal_spleen_morphology0.56765383
148MP0006138_congestive_heart_failure0.56158635
149MP0005646_abnormal_pituitary_gland0.56078893
150MP0005620_abnormal_muscle_contractility0.54890157
151MP0005075_abnormal_melanosome_morpholog0.54676708
152MP0002972_abnormal_cardiac_muscle0.53976102
153MP0006054_spinal_hemorrhage0.53541324
154MP0010368_abnormal_lymphatic_system0.53393672
155MP0005334_abnormal_fat_pad0.52934655

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42453171
2Hepatic necrosis (HP:0002605)4.40823363
3Dicarboxylic aciduria (HP:0003215)4.34076276
4Abnormality of dicarboxylic acid metabolism (HP:0010995)4.34076276
5Hyperglycinemia (HP:0002154)4.00689089
6Hepatocellular necrosis (HP:0001404)3.98203245
7* Cerebral edema (HP:0002181)3.97061366
8* Acute necrotizing encephalopathy (HP:0006965)3.81828525
9* Acute encephalopathy (HP:0006846)3.80859470
10Hyperammonemia (HP:0001987)3.80670351
11* Lactic acidosis (HP:0003128)3.79024231
12* Abnormal mitochondria in muscle tissue (HP:0008316)3.77571065
13* Increased CSF lactate (HP:0002490)3.74936593
14Hypobetalipoproteinemia (HP:0003563)3.73208510
15Intrahepatic cholestasis (HP:0001406)3.68081498
16Hyperglycinuria (HP:0003108)3.67590170
17* Mitochondrial inheritance (HP:0001427)3.64616447
18Abnormality of glycolysis (HP:0004366)3.64260438
19Increased serum pyruvate (HP:0003542)3.64260438
20Abnormality of glycine metabolism (HP:0010895)3.62800347
21Abnormality of serine family amino acid metabolism (HP:0010894)3.62800347
22Ketosis (HP:0001946)3.60225928
23Abnormality of the heme biosynthetic pathway (HP:0010472)3.56827261
24Methylmalonic aciduria (HP:0012120)3.50744867
25Prolonged partial thromboplastin time (HP:0003645)3.49467350
26Hypoglycemic coma (HP:0001325)3.38832540
27Increased serum lactate (HP:0002151)3.36591020
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35157261
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35157261
30Increased muscle lipid content (HP:0009058)3.17878881
31Abnormality of serum amino acid levels (HP:0003112)3.14860223
32Increased intramyocellular lipid droplets (HP:0012240)3.14772492
33* Lethargy (HP:0001254)3.14476845
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.13837377
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13819986
36Generalized aminoaciduria (HP:0002909)3.12052794
37Lipid accumulation in hepatocytes (HP:0006561)3.04960859
38Pancreatic cysts (HP:0001737)3.01475880
39* Progressive macrocephaly (HP:0004481)3.00897325
40Opisthotonus (HP:0002179)2.99249574
41Ketoacidosis (HP:0001993)2.98082856
42* Exercise intolerance (HP:0003546)2.95760699
43Abnormality of fatty-acid metabolism (HP:0004359)2.95506480
44Pancreatic fibrosis (HP:0100732)2.95472740
45Nausea (HP:0002018)2.90011983
46Medial flaring of the eyebrow (HP:0010747)2.89889496
47Metabolic acidosis (HP:0001942)2.88662657
48Deep venous thrombosis (HP:0002625)2.86453957
49True hermaphroditism (HP:0010459)2.84133506
50Microvesicular hepatic steatosis (HP:0001414)2.83629633
51Progressive muscle weakness (HP:0003323)2.80723402
52Increased hepatocellular lipid droplets (HP:0006565)2.80212133
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73936938
54Abnormality of alanine metabolism (HP:0010916)2.73936938
55Hyperalaninemia (HP:0003348)2.73936938
56Hyperbilirubinemia (HP:0002904)2.73281921
57Ragged-red muscle fibers (HP:0003200)2.72106428
58Abnormality of methionine metabolism (HP:0010901)2.71430967
59Myoglobinuria (HP:0002913)2.68395149
60* Optic disc pallor (HP:0000543)2.68006446
61Delayed CNS myelination (HP:0002188)2.62802960
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61590042
63Conjugated hyperbilirubinemia (HP:0002908)2.59121907
64* Vomiting (HP:0002013)2.56232278
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56060907
66Proximal tubulopathy (HP:0000114)2.54962012
67Palpitations (HP:0001962)2.53071533
683-Methylglutaconic aciduria (HP:0003535)2.47653413
69Hypolipoproteinemia (HP:0010981)2.46686322
70Xanthomatosis (HP:0000991)2.46553939
71Abnormality of the intrinsic pathway (HP:0010989)2.46394270
72Aplastic anemia (HP:0001915)2.46204467
73Abnormality of midbrain morphology (HP:0002418)2.44671240
74Molar tooth sign on MRI (HP:0002419)2.44671240
75Abnormal number of erythroid precursors (HP:0012131)2.43320249
76Abnormality of cells of the erythroid lineage (HP:0012130)2.41908271
77Neoplasm of the adrenal gland (HP:0100631)2.40896384
78Rhabdomyolysis (HP:0003201)2.39835947
79Nemaline bodies (HP:0003798)2.37845254
80Hyperlipoproteinemia (HP:0010980)2.34561195
81* Respiratory failure (HP:0002878)2.32452960
82Type II lissencephaly (HP:0007260)2.31571468
83Spontaneous abortion (HP:0005268)2.29230644
84Methylmalonic acidemia (HP:0002912)2.28043040
85Oral leukoplakia (HP:0002745)2.27358312
86Renal Fanconi syndrome (HP:0001994)2.25446041
87Abnormality of urine glucose concentration (HP:0011016)2.24810024
88Glycosuria (HP:0003076)2.24810024
89Hyperinsulinemic hypoglycemia (HP:0000825)2.22524983
90Muscle fiber inclusion bodies (HP:0100299)2.22202530
91Congenital primary aphakia (HP:0007707)2.20096937
92CNS demyelination (HP:0007305)2.19665499
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.17084183
94Abnormal biliary tract physiology (HP:0012439)2.15791661
95Bile duct proliferation (HP:0001408)2.15791661
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15739773
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15024787
98Renal cortical cysts (HP:0000803)2.14748497
99Cerebral hypomyelination (HP:0006808)2.13080850
100Abnormality of pyrimidine metabolism (HP:0004353)2.10355228
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10155147
102Abnormal protein N-linked glycosylation (HP:0012347)2.10155147
103Abnormal protein glycosylation (HP:0012346)2.10155147
104Abnormal glycosylation (HP:0012345)2.10155147
105Gait imbalance (HP:0002141)2.10107496
106Type I transferrin isoform profile (HP:0003642)2.07806558
107Fat malabsorption (HP:0002630)2.07197336
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05478878
109Abnormality of the common coagulation pathway (HP:0010990)2.04164475
110Sclerocornea (HP:0000647)2.03630926
111Joint hemorrhage (HP:0005261)2.00627804
112Spastic diplegia (HP:0001264)1.99272139
113Large for gestational age (HP:0001520)1.99040588
114Abolished electroretinogram (ERG) (HP:0000550)1.98036506
115Attenuation of retinal blood vessels (HP:0007843)1.97167716
116Neuroendocrine neoplasm (HP:0100634)1.96522090
117Exercise-induced muscle cramps (HP:0003710)1.96201668
118Progressive external ophthalmoplegia (HP:0000590)1.95717439
119Respiratory difficulties (HP:0002880)1.95663144
120Hypercholesterolemia (HP:0003124)1.94657034
121Nephrogenic diabetes insipidus (HP:0009806)1.94424122
122Cholelithiasis (HP:0001081)1.93974459
123Neoplasm of head and neck (HP:0012288)1.91916417
124Esophageal neoplasm (HP:0100751)1.91916417
125Muscle hypertrophy of the lower extremities (HP:0008968)1.91250926
126Type 2 muscle fiber atrophy (HP:0003554)1.90432590
127Abnormality of vitamin B metabolism (HP:0004340)1.89299975
128Calf muscle hypertrophy (HP:0008981)1.88463812
129* Leukodystrophy (HP:0002415)1.88220936
130Abnormality of the renal cortex (HP:0011035)1.86205372
131Complement deficiency (HP:0004431)1.86005102
132Pancytopenia (HP:0001876)1.85788458
133Gliosis (HP:0002171)1.85374912
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.84667704
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84564014
136Inability to walk (HP:0002540)1.83504619
137Delayed gross motor development (HP:0002194)1.82473260
138Hypoglycemic seizures (HP:0002173)1.80925389
139Colon cancer (HP:0003003)1.80803510
140Congenital hepatic fibrosis (HP:0002612)1.80085718
141Neoplasm of the adrenal cortex (HP:0100641)1.79928951
142Occipital encephalocele (HP:0002085)1.79707051
143Exertional dyspnea (HP:0002875)1.78285829
144Tubulointerstitial nephritis (HP:0001970)1.77592251
145Nephronophthisis (HP:0000090)1.77256048
146Posterior subcapsular cataract (HP:0007787)1.76280956
147Symptomatic seizures (HP:0011145)1.75396822
148Hypothermia (HP:0002045)1.74466445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.67751514
2BCKDK4.85598989
3MAP4K23.83770036
4EIF2AK13.09761279
5NME22.94577239
6FRK2.85987114
7WEE12.58800001
8VRK22.52980983
9MST42.49457467
10BMPR1B2.48574937
11TRIM282.42980249
12CCNB12.42333186
13CDK192.41941528
14BUB12.22918146
15PINK12.14772515
16MAP4K12.11845461
17MUSK2.09432997
18ACVR1B2.08318378
19ADRBK22.08284221
20NEK11.85972324
21MAP2K71.77093991
22PDK41.76531745
23PDK31.76531745
24NUAK11.72772587
25OBSCN1.65977924
26PBK1.63165951
27PHKG21.54450407
28PHKG11.54450407
29LIMK11.54191313
30PIM21.53606831
31KDR1.52759325
32NME11.49715704
33SRPK11.46072780
34MYLK1.45738240
35TSSK61.42232556
36VRK11.36576807
37CASK1.34351688
38MAP3K111.29511034
39MKNK11.27856385
40CSNK1G11.25075627
41EIF2AK31.22600623
42PAK31.20054085
43MAP2K31.19623798
44MKNK21.19032899
45MAPK111.18914878
46AKT31.18132085
47BCR1.16943647
48BRSK21.15261324
49SIK31.11981136
50MAPKAPK31.11483687
51OXSR11.09931655
52PLK41.07544181
53DAPK11.04594315
54CDC71.03741276
55TIE11.03364898
56FLT30.99553638
57PLK10.98063088
58TTK0.96530901
59EEF2K0.96233056
60INSRR0.95213195
61ERBB30.91746804
62WNK40.91387907
63CSNK1G20.87905027
64MAP2K60.86755137
65PRKCE0.83345790
66MAPK130.81672493
67PDK20.79028204
68DYRK20.78582206
69ZAK0.78428014
70ERBB40.77496546
71TNIK0.77330676
72ADRBK10.73662608
73ARAF0.73495128
74MAP3K120.73101356
75TXK0.72728084
76PIK3CG0.72232352
77PRKCG0.71725204
78MAP2K40.71097968
79BRAF0.69301667
80FGFR40.69165087
81TAOK20.67551232
82RPS6KB10.66324844
83PAK60.65391236
84NLK0.65220895
85NEK90.65027313
86IKBKE0.62131062
87CSNK1A1L0.62081530
88GRK60.61523506
89ABL20.60244318
90PASK0.59428325
91RAF10.59284838
92TAOK30.58752694
93BRSK10.58505391
94GRK70.57425043
95AURKB0.56838276
96WNK30.56674543
97MAPKAPK50.55723385
98STK38L0.55515569
99AURKA0.55031090
100CAMK2D0.53441594
101RPS6KA50.52961235
102CDK70.52820637
103CSNK2A10.50571265
104DYRK30.50241551
105NEK20.49921492
106TLK10.49709641
107DAPK30.49237875
108LMTK20.48961306
109TYK20.48208148
110MAPK120.47621191
111PRKAA20.46938552
112CAMK2A0.45448612
113CSNK2A20.45085191
114MAP3K40.44830897
115DAPK20.44246541
116CSF1R0.43581968
117RIPK10.41795051
118ATM0.41529508
119RPS6KA40.40875467
120PRKACA0.38608129
121RPS6KB20.38440550
122CAMKK20.37936265
123TGFBR10.37876248
124PLK30.37858498
125CSNK1G30.37412845
126CSNK1A10.36705605
127EIF2AK20.36526865
128TRPM70.36395847
129SYK0.36208533
130FER0.36109180
131ATR0.34733206
132PRKCI0.33938393
133FGFR30.32878919
134ZAP700.32783222
135CAMK2G0.32161546
136CLK10.31205261
137GRK50.30142494
138PIM10.30058026
139GRK10.28842303
140MAPK40.26462722
141TTN0.26166899
142TEC0.25965606
143TESK20.24449259
144CDK40.23899477
145MINK10.22214917
146PLK20.21903633

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.19533616
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.07910736
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.98127049
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68724074
5Propanoate metabolism_Homo sapiens_hsa006402.60326690
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.56069235
7Proteasome_Homo sapiens_hsa030502.51950744
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30127934
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28619757
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19841034
11Fatty acid degradation_Homo sapiens_hsa000712.19234752
12DNA replication_Homo sapiens_hsa030302.16747306
13Pyruvate metabolism_Homo sapiens_hsa006202.13664485
14Carbon metabolism_Homo sapiens_hsa012002.06301622
15Parkinsons disease_Homo sapiens_hsa050121.99558398
16Oxidative phosphorylation_Homo sapiens_hsa001901.99445444
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89029400
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88455463
19Peroxisome_Homo sapiens_hsa041461.85049444
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.79643348
21Ribosome_Homo sapiens_hsa030101.78884128
22Biosynthesis of amino acids_Homo sapiens_hsa012301.78451307
23Arginine biosynthesis_Homo sapiens_hsa002201.74384681
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69926311
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68169093
26Folate biosynthesis_Homo sapiens_hsa007901.63295213
27Butanoate metabolism_Homo sapiens_hsa006501.62530514
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.62486302
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.61780219
30Tryptophan metabolism_Homo sapiens_hsa003801.60124351
31RNA polymerase_Homo sapiens_hsa030201.56995730
32Mismatch repair_Homo sapiens_hsa034301.56194685
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50131440
34Pyrimidine metabolism_Homo sapiens_hsa002401.48619901
35One carbon pool by folate_Homo sapiens_hsa006701.48279022
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46748571
37Fatty acid metabolism_Homo sapiens_hsa012121.46119494
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45605618
39Fatty acid elongation_Homo sapiens_hsa000621.42720522
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40229001
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36625524
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34716650
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33194336
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32367143
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30768979
46Huntingtons disease_Homo sapiens_hsa050161.30416864
47beta-Alanine metabolism_Homo sapiens_hsa004101.27309333
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24507745
49Alzheimers disease_Homo sapiens_hsa050101.21517607
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.20919298
51Complement and coagulation cascades_Homo sapiens_hsa046101.20632967
52Selenocompound metabolism_Homo sapiens_hsa004501.17579413
53Fructose and mannose metabolism_Homo sapiens_hsa000511.17345426
54Chemical carcinogenesis_Homo sapiens_hsa052041.16782439
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14363368
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14215386
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13621710
58Phenylalanine metabolism_Homo sapiens_hsa003601.12676947
59Pentose phosphate pathway_Homo sapiens_hsa000301.10860966
60Collecting duct acid secretion_Homo sapiens_hsa049661.10150166
61Phototransduction_Homo sapiens_hsa047441.04019971
62Tyrosine metabolism_Homo sapiens_hsa003501.00217971
63PPAR signaling pathway_Homo sapiens_hsa033200.98588490
64Nitrogen metabolism_Homo sapiens_hsa009100.97299014
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.96316569
66Histidine metabolism_Homo sapiens_hsa003400.95625932
67Nucleotide excision repair_Homo sapiens_hsa034200.95142373
68Caffeine metabolism_Homo sapiens_hsa002320.94136561
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90258088
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87236363
71Base excision repair_Homo sapiens_hsa034100.85200885
72Starch and sucrose metabolism_Homo sapiens_hsa005000.85095538
73Metabolic pathways_Homo sapiens_hsa011000.84777220
74Glutathione metabolism_Homo sapiens_hsa004800.84655582
75Purine metabolism_Homo sapiens_hsa002300.81213670
76Non-homologous end-joining_Homo sapiens_hsa034500.81106498
77Sulfur relay system_Homo sapiens_hsa041220.81003369
78Spliceosome_Homo sapiens_hsa030400.78449586
79Retinol metabolism_Homo sapiens_hsa008300.77746617
80Arginine and proline metabolism_Homo sapiens_hsa003300.75521498
81Homologous recombination_Homo sapiens_hsa034400.75162815
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71807064
83Vitamin B6 metabolism_Homo sapiens_hsa007500.70823860
84Vitamin digestion and absorption_Homo sapiens_hsa049770.69119606
85RNA transport_Homo sapiens_hsa030130.68558504
86Cardiac muscle contraction_Homo sapiens_hsa042600.66765243
87Linoleic acid metabolism_Homo sapiens_hsa005910.65536894
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61052926
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54656384
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51550029
91RNA degradation_Homo sapiens_hsa030180.50262834
92Sulfur metabolism_Homo sapiens_hsa009200.49685331
93Fat digestion and absorption_Homo sapiens_hsa049750.47509559
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47410592
95ABC transporters_Homo sapiens_hsa020100.44968390
96Circadian rhythm_Homo sapiens_hsa047100.41790334
97Ether lipid metabolism_Homo sapiens_hsa005650.39874856
98Mineral absorption_Homo sapiens_hsa049780.39629646
99Staphylococcus aureus infection_Homo sapiens_hsa051500.37836065
100Fanconi anemia pathway_Homo sapiens_hsa034600.37218821
101Bile secretion_Homo sapiens_hsa049760.34966185
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34836438
103Oocyte meiosis_Homo sapiens_hsa041140.34144643
104Protein export_Homo sapiens_hsa030600.31605051
105Cell cycle_Homo sapiens_hsa041100.31604896
106Galactose metabolism_Homo sapiens_hsa000520.30771702
107Rheumatoid arthritis_Homo sapiens_hsa053230.30049200
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29324036
109Basal transcription factors_Homo sapiens_hsa030220.29243286
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28107535
111p53 signaling pathway_Homo sapiens_hsa041150.27907363
112N-Glycan biosynthesis_Homo sapiens_hsa005100.25539103
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24544387
114Regulation of autophagy_Homo sapiens_hsa041400.23972667
115Glycerolipid metabolism_Homo sapiens_hsa005610.23328674
116Glucagon signaling pathway_Homo sapiens_hsa049220.22385310
117Systemic lupus erythematosus_Homo sapiens_hsa053220.15087954
118Steroid biosynthesis_Homo sapiens_hsa001000.14623549
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14568361
120Lysine degradation_Homo sapiens_hsa003100.10435888

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