NDST4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.22001463
2negative regulation of translation, ncRNA-mediated (GO:0040033)6.22001463
3regulation of translation, ncRNA-mediated (GO:0045974)6.22001463
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.12869354
5negative regulation of astrocyte differentiation (GO:0048712)4.74042299
6neuron cell-cell adhesion (GO:0007158)4.73574568
7regulation of timing of cell differentiation (GO:0048505)4.62682109
8vocalization behavior (GO:0071625)4.54283435
9replication fork processing (GO:0031297)4.53897994
10glutamate receptor signaling pathway (GO:0007215)4.49047105
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46783125
12regulation of development, heterochronic (GO:0040034)4.36508982
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32037017
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.31862098
15synaptic transmission, glutamatergic (GO:0035249)4.30935214
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.23416235
17neuron-neuron synaptic transmission (GO:0007270)4.19162515
18hindbrain development (GO:0030902)4.17704833
19lateral sprouting from an epithelium (GO:0060601)4.14253216
20protein localization to synapse (GO:0035418)4.12542027
21regulation of glutamate receptor signaling pathway (GO:1900449)4.11248702
22positive regulation of synaptic transmission, GABAergic (GO:0032230)4.10307596
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08207862
24translesion synthesis (GO:0019985)4.05844464
25startle response (GO:0001964)4.04091470
26central nervous system projection neuron axonogenesis (GO:0021952)3.97084562
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.95878764
28limb bud formation (GO:0060174)3.95751374
29pyrimidine nucleobase catabolic process (GO:0006208)3.93865030
30neural tube formation (GO:0001841)3.93333312
31cerebral cortex radially oriented cell migration (GO:0021799)3.85488162
32synaptic vesicle exocytosis (GO:0016079)3.80787735
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79713636
34DNA damage response, detection of DNA damage (GO:0042769)3.77494292
35presynaptic membrane assembly (GO:0097105)3.76880662
36neuron recognition (GO:0008038)3.67214437
37kidney morphogenesis (GO:0060993)3.66495095
38dentate gyrus development (GO:0021542)3.65609016
39retinal ganglion cell axon guidance (GO:0031290)3.65162855
40inner ear receptor stereocilium organization (GO:0060122)3.59618460
41nonmotile primary cilium assembly (GO:0035058)3.56362803
42olfactory bulb development (GO:0021772)3.55979432
43presynaptic membrane organization (GO:0097090)3.55499627
44innervation (GO:0060384)3.55076053
45central nervous system neuron axonogenesis (GO:0021955)3.48536635
46regulation of synaptic vesicle exocytosis (GO:2000300)3.47293832
47proline transport (GO:0015824)3.47155897
48DNA strand renaturation (GO:0000733)3.44518376
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43435711
50cell proliferation in forebrain (GO:0021846)3.41903015
51detection of calcium ion (GO:0005513)3.38431505
52transmission of nerve impulse (GO:0019226)3.37564717
53otic vesicle formation (GO:0030916)3.34001618
54locomotory exploration behavior (GO:0035641)3.31972877
55response to histamine (GO:0034776)3.31585238
56regulation of synaptic vesicle transport (GO:1902803)3.30498738
57cell wall macromolecule catabolic process (GO:0016998)3.29787569
58postsynaptic membrane organization (GO:0001941)3.29320542
59neuronal action potential propagation (GO:0019227)3.28777511
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27295876
61intraciliary transport (GO:0042073)3.26884454
62positive regulation of male gonad development (GO:2000020)3.26747651
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.26458565
64long-term memory (GO:0007616)3.24285693
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24138065
66regulation of postsynaptic membrane potential (GO:0060078)3.23606489
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22427847
68neurotransmitter-gated ion channel clustering (GO:0072578)3.21495790
69axonal fasciculation (GO:0007413)3.20406760
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20027053
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.17662775
72regulation of neuronal synaptic plasticity (GO:0048168)3.16966495
73synaptic vesicle endocytosis (GO:0048488)3.15711339
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15442689
75postreplication repair (GO:0006301)3.14498221
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13890791
77regulation of synaptic transmission, GABAergic (GO:0032228)3.12207550
78cellular response to interleukin-15 (GO:0071350)3.11969055
79nucleobase catabolic process (GO:0046113)3.11871667
80glutamate secretion (GO:0014047)3.11446023
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10884061
82exploration behavior (GO:0035640)3.10340317
83tongue development (GO:0043586)3.07861825
84long-term synaptic potentiation (GO:0060291)3.07847005
85behavioral fear response (GO:0001662)3.07437881
86behavioral defense response (GO:0002209)3.07437881
87regulation of vesicle fusion (GO:0031338)3.06550693
88somite development (GO:0061053)3.05687752
89negative regulation of DNA recombination (GO:0045910)3.05521598
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05108240
91DNA integration (GO:0015074)3.04829581
92neurotransmitter secretion (GO:0007269)3.04407831
93chemosensory behavior (GO:0007635)3.03607580
94regulation of synapse maturation (GO:0090128)3.00664466
95synaptic vesicle maturation (GO:0016188)3.00556571
96membrane depolarization during action potential (GO:0086010)3.00417848
97negative regulation of dendrite development (GO:2000171)3.00171337
98positive regulation of synapse assembly (GO:0051965)2.98822794
99positive regulation of membrane potential (GO:0045838)2.98056390
100epithelial cilium movement (GO:0003351)2.97577959
101serotonin receptor signaling pathway (GO:0007210)2.97440603
102synaptic vesicle docking involved in exocytosis (GO:0016081)2.97319330
103learning (GO:0007612)2.94319575
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93409094
105DNA double-strand break processing (GO:0000729)2.92750374
106regulation of collateral sprouting (GO:0048670)2.92537284
107regulation of synaptic plasticity (GO:0048167)2.91455728
108long term synaptic depression (GO:0060292)2.90550864
109positive regulation of synapse maturation (GO:0090129)2.89104167
110protein sumoylation (GO:0016925)2.88909044
111membrane depolarization (GO:0051899)2.88841111
112dendritic spine organization (GO:0097061)2.88092160
113response to amphetamine (GO:0001975)2.87686220
114ephrin receptor signaling pathway (GO:0048013)2.87663863
115exocrine pancreas development (GO:0031017)2.86401702
116negative regulation of glial cell differentiation (GO:0045686)2.84970718
117calcium ion-dependent exocytosis (GO:0017156)2.84962915
118positive regulation of neurotransmitter secretion (GO:0001956)2.84236437
119fear response (GO:0042596)2.82806368
120mechanosensory behavior (GO:0007638)2.82429926
121cochlea development (GO:0090102)2.82313228
122positive regulation of gastrulation (GO:2000543)2.82254764
123transcription from mitochondrial promoter (GO:0006390)2.81977313
124retinal cone cell development (GO:0046549)2.80968445
125cilium organization (GO:0044782)2.79836379
126cilium assembly (GO:0042384)2.79656872
127regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79176012
128regulation of male gonad development (GO:2000018)2.79072674
129neurotransmitter transport (GO:0006836)2.78474715
130negative regulation of neurotransmitter transport (GO:0051589)2.78262366
131kinetochore assembly (GO:0051382)2.77925890
132cell wall macromolecule metabolic process (GO:0044036)2.77646144
133calcium ion import (GO:0070509)2.77365510
134suckling behavior (GO:0001967)2.77365008
135regulation of respiratory system process (GO:0044065)2.77301210
136positive regulation of dendritic spine development (GO:0060999)2.76879665
137smoothened signaling pathway (GO:0007224)2.76218328
138regulation of female receptivity (GO:0045924)2.74608195
139synaptic transmission (GO:0007268)2.73926096
140C4-dicarboxylate transport (GO:0015740)2.73915829
141forebrain neuron differentiation (GO:0021879)2.73842768
142regulation of neurotransmitter secretion (GO:0046928)2.73739350
143regulation of astrocyte differentiation (GO:0048710)2.72608208
144lens development in camera-type eye (GO:0002088)2.71634183
145urinary tract smooth muscle contraction (GO:0014848)2.70670277
146glycine transport (GO:0015816)2.70085082
147positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69940740
148regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.69706611
149female mating behavior (GO:0060180)2.69466599
150regulation of synapse assembly (GO:0051963)2.69175036
151righting reflex (GO:0060013)2.68400338
152regulation of dendritic spine morphogenesis (GO:0061001)2.68254298
153membrane hyperpolarization (GO:0060081)2.67820024
154synapse assembly (GO:0007416)2.67617347
155regulation of glutamate secretion (GO:0014048)2.67393490
156reciprocal DNA recombination (GO:0035825)2.66911666
157reciprocal meiotic recombination (GO:0007131)2.66911666
158positive regulation of oligodendrocyte differentiation (GO:0048714)2.66879351
159synaptic transmission, dopaminergic (GO:0001963)2.66201095
160sleep (GO:0030431)2.65843598
161thalamus development (GO:0021794)2.65725534
162positive regulation of vesicle fusion (GO:0031340)2.64438876
163spinal cord development (GO:0021510)2.64371391
164positive regulation of cell cycle G2/M phase transition (GO:1902751)2.63374199
165positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.63374199
166dendritic spine morphogenesis (GO:0060997)2.62698325
167cilium or flagellum-dependent cell motility (GO:0001539)2.62598473
168positive regulation of neurotransmitter transport (GO:0051590)2.62487478
169dorsal/ventral pattern formation (GO:0009953)2.60817780
170negative regulation of axon extension (GO:0030517)2.59703483
171protein K6-linked ubiquitination (GO:0085020)2.57202328
172substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.57057090
173substrate-independent telencephalic tangential migration (GO:0021826)2.57057090
174neuron fate determination (GO:0048664)2.55184592
175appendage development (GO:0048736)2.54343340
176limb development (GO:0060173)2.54343340
177positive regulation of neuroblast proliferation (GO:0002052)2.53350405
178positive regulation of chondrocyte differentiation (GO:0032332)2.52679756
179regulation of neuron projection regeneration (GO:0070570)2.52376589
180regulation of axon regeneration (GO:0048679)2.52376589
181kynurenine metabolic process (GO:0070189)2.50848997
182Sertoli cell development (GO:0060009)2.48917060
183artery development (GO:0060840)2.48475341
184embryonic epithelial tube formation (GO:0001838)2.48005906
185cerebral cortex cell migration (GO:0021795)2.47323028
186cerebral cortex neuron differentiation (GO:0021895)2.46873457
187cilium morphogenesis (GO:0060271)2.46613783
188male sex determination (GO:0030238)2.45104777
189interferon-gamma secretion (GO:0072643)2.45004883
190negative regulation of axon guidance (GO:1902668)2.44292899
191glycerophospholipid catabolic process (GO:0046475)2.44144109
192keratinocyte development (GO:0003334)2.43774735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28575286
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.51392037
3GBX2_23144817_ChIP-Seq_PC3_Human4.14203841
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.42799794
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67004913
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66080531
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52488004
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48444485
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45119813
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43033967
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33691926
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33014392
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.25281624
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22285938
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20259205
16REST_21632747_ChIP-Seq_MESCs_Mouse2.19951103
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11605614
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.09917920
19TAF15_26573619_Chip-Seq_HEK293_Human2.08332852
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05643549
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04800182
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04800182
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02550074
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00168444
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94944218
26* P300_19829295_ChIP-Seq_ESCs_Human1.93164699
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.93150760
28VDR_22108803_ChIP-Seq_LS180_Human1.92145467
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92078832
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90990076
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88366023
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.87681958
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86154182
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84052353
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.83483272
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83465329
37IGF1R_20145208_ChIP-Seq_DFB_Human1.83009421
38DROSHA_22980978_ChIP-Seq_HELA_Human1.79594862
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.77448677
40FUS_26573619_Chip-Seq_HEK293_Human1.77218774
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75871851
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73270492
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63550229
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.62184616
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57922300
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.57399804
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.55542560
48RNF2_27304074_Chip-Seq_NSC_Mouse1.52209116
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.51331413
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50084436
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49814249
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47511276
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.47476962
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46704964
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45655726
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45605502
57STAT3_23295773_ChIP-Seq_U87_Human1.41482281
58* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40201010
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39868251
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38758149
61AR_25329375_ChIP-Seq_VCAP_Human1.38053294
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37168799
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37129394
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35764442
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.35388046
66* P53_22387025_ChIP-Seq_ESCs_Mouse1.34484269
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.34060043
68ZNF274_21170338_ChIP-Seq_K562_Hela1.33164334
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32966504
70* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32559786
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30485468
72CBP_20019798_ChIP-Seq_JUKART_Human1.29522195
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29522195
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28529321
75* TCF4_23295773_ChIP-Seq_U87_Human1.28236100
76IRF1_19129219_ChIP-ChIP_H3396_Human1.27939391
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.27676023
78AR_21572438_ChIP-Seq_LNCaP_Human1.26426310
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26383594
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.25731949
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25201554
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25119658
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.22636739
84ER_23166858_ChIP-Seq_MCF-7_Human1.22587343
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22321301
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21071380
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20989144
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20103266
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19819295
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.19359290
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.18928222
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18878288
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.17181523
94P300_18555785_Chip-Seq_ESCs_Mouse1.16434180
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.16039158
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15790759
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15355378
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14837120
99* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14090253
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.13866190
101TP53_22573176_ChIP-Seq_HFKS_Human1.13864094
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13678149
103* KDM2B_26808549_Chip-Seq_REH_Human1.13653102
104BCAT_22108803_ChIP-Seq_LS180_Human1.13086616
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.12390590
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.09532587
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09124797
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09061986
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09017451
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08833439
111* TP53_18474530_ChIP-ChIP_U2OS_Human1.07658102
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.07588020
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07210463
114* SOX9_26525672_Chip-Seq_HEART_Mouse1.06681280
115MYC_18940864_ChIP-ChIP_HL60_Human1.06485454
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06010420
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05797345
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05797345
119* JUN_21703547_ChIP-Seq_K562_Human1.05548366
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05312427
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05293197
122EWS_26573619_Chip-Seq_HEK293_Human1.04771014
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.04767254
124ELK1_19687146_ChIP-ChIP_HELA_Human1.04428783
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04260829
126E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02928112
127TCF4_22108803_ChIP-Seq_LS180_Human1.01552383
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01234961
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.00744618
130EST1_17652178_ChIP-ChIP_JURKAT_Human0.99323752
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98621603
132* TAL1_26923725_Chip-Seq_HPCs_Mouse0.97442877
133SOX2_19829295_ChIP-Seq_ESCs_Human0.96188550
134NANOG_19829295_ChIP-Seq_ESCs_Human0.96188550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.83786487
2MP0004859_abnormal_synaptic_plasticity4.65219631
3MP0000566_synostosis3.89753141
4MP0003635_abnormal_synaptic_transmissio3.30471820
5MP0004270_analgesia3.17225307
6MP0001968_abnormal_touch/_nociception3.07676273
7MP0009745_abnormal_behavioral_response3.05031634
8MP0005645_abnormal_hypothalamus_physiol3.04756841
9MP0002736_abnormal_nociception_after2.95220724
10MP0002102_abnormal_ear_morphology2.87939710
11MP0002735_abnormal_chemical_nociception2.84708156
12MP0002063_abnormal_learning/memory/cond2.78863149
13MP0002572_abnormal_emotion/affect_behav2.66326220
14MP0002272_abnormal_nervous_system2.63101826
15MP0002064_seizures2.63068792
16MP0006276_abnormal_autonomic_nervous2.61974930
17MP0001188_hyperpigmentation2.61580838
18MP0008789_abnormal_olfactory_epithelium2.53255343
19MP0003787_abnormal_imprinting2.47686888
20MP0009046_muscle_twitch2.41779262
21MP0001529_abnormal_vocalization2.35439202
22MP0002734_abnormal_mechanical_nocicepti2.34939451
23MP0001486_abnormal_startle_reflex2.32905761
24MP0005423_abnormal_somatic_nervous2.30721013
25MP0001501_abnormal_sleep_pattern2.30437163
26MP0009697_abnormal_copulation2.09619304
27MP0005248_abnormal_Harderian_gland2.06726087
28MP0010030_abnormal_orbit_morphology2.05724314
29MP0001440_abnormal_grooming_behavior2.05107206
30MP0002938_white_spotting2.03097673
31MP0002184_abnormal_innervation2.00365348
32MP0002067_abnormal_sensory_capabilities1.96894729
33MP0002909_abnormal_adrenal_gland1.87557275
34MP0009053_abnormal_anal_canal1.84866906
35MP0003122_maternal_imprinting1.81104761
36MP0002733_abnormal_thermal_nociception1.80938337
37MP0004133_heterotaxia1.80682469
38MP0003938_abnormal_ear_development1.79478846
39MP0003937_abnormal_limbs/digits/tail_de1.76846876
40MP0002822_catalepsy1.75231678
41MP0001970_abnormal_pain_threshold1.75047977
42MP0010386_abnormal_urinary_bladder1.74243652
43MP0002557_abnormal_social/conspecific_i1.72769886
44MP0005379_endocrine/exocrine_gland_phen1.65907176
45MP0005646_abnormal_pituitary_gland1.65584557
46MP0000778_abnormal_nervous_system1.64322764
47MP0001293_anophthalmia1.64200345
48MP0002233_abnormal_nose_morphology1.63390562
49MP0003879_abnormal_hair_cell1.62521117
50MP0006292_abnormal_olfactory_placode1.59663129
51MP0002653_abnormal_ependyma_morphology1.55065341
52MP0005410_abnormal_fertilization1.52783169
53MP0001502_abnormal_circadian_rhythm1.49101369
54MP0001984_abnormal_olfaction1.48166148
55MP0000013_abnormal_adipose_tissue1.47353835
56MP0004924_abnormal_behavior1.47047223
57MP0005386_behavior/neurological_phenoty1.47047223
58MP0003119_abnormal_digestive_system1.37533875
59MP0000955_abnormal_spinal_cord1.37151050
60MP0000049_abnormal_middle_ear1.35933070
61MP0003718_maternal_effect1.34160782
62MP0000569_abnormal_digit_pigmentation1.33904723
63MP0003755_abnormal_palate_morphology1.31103875
64MP0002638_abnormal_pupillary_reflex1.30112820
65MP0002837_dystrophic_cardiac_calcinosis1.29280039
66MP0004742_abnormal_vestibular_system1.28396689
67MP0001986_abnormal_taste_sensitivity1.27629485
68MP0005084_abnormal_gallbladder_morpholo1.26794657
69MP0004142_abnormal_muscle_tone1.26104013
70MP0004811_abnormal_neuron_physiology1.26040759
71MP0008877_abnormal_DNA_methylation1.25502471
72MP0001286_abnormal_eye_development1.25246023
73MP0002697_abnormal_eye_size1.23993961
74MP0002876_abnormal_thyroid_physiology1.23702624
75MP0003861_abnormal_nervous_system1.23255651
76MP0001905_abnormal_dopamine_level1.22531894
77MP0005551_abnormal_eye_electrophysiolog1.22010668
78MP0002882_abnormal_neuron_morphology1.19957610
79MP0005409_darkened_coat_color1.18432218
80MP0008569_lethality_at_weaning1.16814518
81MP0001177_atelectasis1.16393749
82MP0000647_abnormal_sebaceous_gland1.15445025
83MP0002066_abnormal_motor_capabilities/c1.14469250
84MP0004858_abnormal_nervous_system1.14273867
85MP0005195_abnormal_posterior_eye1.13576884
86MP0005391_vision/eye_phenotype1.06277644
87MP0001963_abnormal_hearing_physiology1.05412774
88MP0003633_abnormal_nervous_system1.05410744
89MP0003385_abnormal_body_wall1.04511185
90MP0000534_abnormal_ureter_morphology1.01464954
91MP0002163_abnormal_gland_morphology1.01155457
92MP0002282_abnormal_trachea_morphology0.99390720
93MP0005171_absent_coat_pigmentation0.99086687
94MP0000427_abnormal_hair_cycle0.98916558
95MP0003283_abnormal_digestive_organ0.98596358
96MP0003183_abnormal_peptide_metabolism0.98419224
97MP0008875_abnormal_xenobiotic_pharmacok0.96094007
98MP0003890_abnormal_embryonic-extraembry0.95977392
99MP0001299_abnormal_eye_distance/0.95501491
100MP0009780_abnormal_chondrocyte_physiolo0.95341544
101MP0000579_abnormal_nail_morphology0.95167280
102MP0003121_genomic_imprinting0.93829355
103MP0004145_abnormal_muscle_electrophysio0.92109286
104MP0002229_neurodegeneration0.91612855
105MP0000631_abnormal_neuroendocrine_gland0.91404372
106MP0001346_abnormal_lacrimal_gland0.90990674
107MP0006072_abnormal_retinal_apoptosis0.90780755
108MP0005187_abnormal_penis_morphology0.89993523
109MP0000428_abnormal_craniofacial_morphol0.89274936
110MP0002069_abnormal_eating/drinking_beha0.88385584
111MP0004885_abnormal_endolymph0.87808033
112MP0002111_abnormal_tail_morphology0.86174116
113MP0001664_abnormal_digestion0.85845477
114MP0002751_abnormal_autonomic_nervous0.85224518
115MP0006035_abnormal_mitochondrial_morpho0.83994347
116MP0002932_abnormal_joint_morphology0.83202482
117MP0005377_hearing/vestibular/ear_phenot0.82535909
118MP0003878_abnormal_ear_physiology0.82535909
119MP0010094_abnormal_chromosome_stability0.82350295
120MP0003631_nervous_system_phenotype0.82265819
121MP0002752_abnormal_somatic_nervous0.82236288
122MP0003137_abnormal_impulse_conducting0.82138829
123MP0000026_abnormal_inner_ear0.81589739
124MP0001765_abnormal_ion_homeostasis0.80868516
125MP0005394_taste/olfaction_phenotype0.80156870
126MP0005499_abnormal_olfactory_system0.80156870
127MP0005253_abnormal_eye_physiology0.80060876
128MP0008058_abnormal_DNA_repair0.79788665
129MP0008872_abnormal_physiological_respon0.79577211
130MP0003935_abnormal_craniofacial_develop0.78791046
131MP0000383_abnormal_hair_follicle0.77995989
132MP0003942_abnormal_urinary_system0.77575124
133MP0001929_abnormal_gametogenesis0.77571490
134MP0003136_yellow_coat_color0.77523366
135MP0002152_abnormal_brain_morphology0.77436160
136MP0004215_abnormal_myocardial_fiber0.77403009
137MP0002210_abnormal_sex_determination0.77142215
138MP0003123_paternal_imprinting0.77133009
139MP0003195_calcinosis0.76708430
140MP0001485_abnormal_pinna_reflex0.76114312
141MP0005535_abnormal_body_temperature0.74694474
142MP0000678_abnormal_parathyroid_gland0.73816177
143MP0004484_altered_response_of0.71952522
144MP0000015_abnormal_ear_pigmentation0.71757957
145MP0002693_abnormal_pancreas_physiology0.70898405
146MP0003698_abnormal_male_reproductive0.68848202
147MP0004043_abnormal_pH_regulation0.67412344
148MP0004085_abnormal_heartbeat0.64640760
149MP0003045_fibrosis0.61251807
150MP0001944_abnormal_pancreas_morphology0.59868634
151MP0004510_myositis0.55911089
152MP0003634_abnormal_glial_cell0.55833471
153MP0008874_decreased_physiological_sensi0.54515367
154MP0002234_abnormal_pharynx_morphology0.51853807

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78473209
2Febrile seizures (HP:0002373)5.40215633
3Epileptic encephalopathy (HP:0200134)4.53245881
4Focal seizures (HP:0007359)4.46724798
5Atonic seizures (HP:0010819)4.30980886
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.19489043
7Absent/shortened dynein arms (HP:0200106)4.19489043
8Renal hypoplasia (HP:0000089)4.07771403
9Hyperventilation (HP:0002883)4.01953575
10True hermaphroditism (HP:0010459)3.84091310
11Hypoplastic nipples (HP:0002557)3.77231761
12Absence seizures (HP:0002121)3.74293775
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.71970688
14Myokymia (HP:0002411)3.64329904
15Visual hallucinations (HP:0002367)3.58862969
16Bifid scrotum (HP:0000048)3.58571020
17Progressive cerebellar ataxia (HP:0002073)3.57513868
18Dialeptic seizures (HP:0011146)3.55641702
19Pancreatic fibrosis (HP:0100732)3.50383815
20Abnormal ciliary motility (HP:0012262)3.38294476
21Abnormality of calcium-phosphate metabolism (HP:0100530)3.32255235
22Generalized tonic-clonic seizures (HP:0002069)3.31458682
23Pancreatic cysts (HP:0001737)3.22412598
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08770284
25Short 4th metacarpal (HP:0010044)3.08770284
26Abnormal respiratory epithelium morphology (HP:0012253)3.05770822
27Abnormal respiratory motile cilium morphology (HP:0005938)3.05770822
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96384705
29Abnormal respiratory motile cilium physiology (HP:0012261)2.92488927
30Intestinal atresia (HP:0011100)2.90297901
31Abnormal hair whorl (HP:0010721)2.88518992
32Broad-based gait (HP:0002136)2.86897907
33Blue irides (HP:0000635)2.84812258
34Protruding tongue (HP:0010808)2.78490980
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.76557413
36Abnormality of the labia minora (HP:0012880)2.72652886
37Postaxial foot polydactyly (HP:0001830)2.72291938
38Hemiparesis (HP:0001269)2.71533203
39Epileptiform EEG discharges (HP:0011182)2.62158133
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.61967374
41Excessive salivation (HP:0003781)2.58925802
42Drooling (HP:0002307)2.58925802
43Tented upper lip vermilion (HP:0010804)2.57948134
44Supranuclear gaze palsy (HP:0000605)2.55987952
45Abolished electroretinogram (ERG) (HP:0000550)2.54760135
46Postaxial hand polydactyly (HP:0001162)2.50154740
47Oligodactyly (HP:0012165)2.48603249
48Absent speech (HP:0001344)2.46234663
49Retinal dysplasia (HP:0007973)2.45483154
50Bile duct proliferation (HP:0001408)2.44623681
51Abnormal biliary tract physiology (HP:0012439)2.44623681
52Rib fusion (HP:0000902)2.43169313
53Medial flaring of the eyebrow (HP:0010747)2.39117559
54Type II lissencephaly (HP:0007260)2.37191915
55Abnormality of the 4th metacarpal (HP:0010012)2.32404323
56Anencephaly (HP:0002323)2.32114170
57Hyperphosphatemia (HP:0002905)2.29201409
58Increased circulating renin level (HP:0000848)2.28915757
59Gait imbalance (HP:0002141)2.28582857
60EEG with generalized epileptiform discharges (HP:0011198)2.28272209
61Gaze-evoked nystagmus (HP:0000640)2.27154592
62Retinal atrophy (HP:0001105)2.26458379
63Truncal ataxia (HP:0002078)2.23409160
643-Methylglutaconic aciduria (HP:0003535)2.22869677
65Abnormal lung lobation (HP:0002101)2.22849926
66Micropenis (HP:0000054)2.22632134
67Aplasia/Hypoplasia of the nipples (HP:0006709)2.20534656
68Amblyopia (HP:0000646)2.19864859
69Decreased circulating renin level (HP:0003351)2.19257988
70Action tremor (HP:0002345)2.18916333
71Pancreatic islet-cell hyperplasia (HP:0004510)2.18890435
72Cystic liver disease (HP:0006706)2.18074043
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.17180106
74Gastrointestinal atresia (HP:0002589)2.16816732
75Lissencephaly (HP:0001339)2.15381606
76Volvulus (HP:0002580)2.14852537
77Hypothermia (HP:0002045)2.14208123
78Colon cancer (HP:0003003)2.13654251
79Cortical dysplasia (HP:0002539)2.12273673
80Papilledema (HP:0001085)2.11526518
81Fair hair (HP:0002286)2.10874811
82Rhinitis (HP:0012384)2.10399607
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.10108919
84Anxiety (HP:0000739)2.09599141
85Nephronophthisis (HP:0000090)2.09328067
86Congenital primary aphakia (HP:0007707)2.08006458
87Pendular nystagmus (HP:0012043)2.07413212
88Generalized hypopigmentation of hair (HP:0011358)2.06978292
89Widely spaced teeth (HP:0000687)2.06878836
90Nephrogenic diabetes insipidus (HP:0009806)2.05446401
91Hypsarrhythmia (HP:0002521)2.05023654
92Narrow forehead (HP:0000341)2.03359134
93Amyotrophic lateral sclerosis (HP:0007354)2.03041286
94Agitation (HP:0000713)2.02993091
95Sclerocornea (HP:0000647)2.02646492
96Abnormality of salivation (HP:0100755)2.01751133
97Dysmetria (HP:0001310)2.01389654
98Abnormality of the aortic arch (HP:0012303)2.01140189
99Wide intermamillary distance (HP:0006610)2.01007713
100Multicystic kidney dysplasia (HP:0000003)2.00796990
101Short tibia (HP:0005736)1.98302094
102Thickened helices (HP:0000391)1.98201250
103Abnormality of the metopic suture (HP:0005556)1.97474768
104Abnormality of the proximal phalanges of the hand (HP:0009834)1.96994040
105Decreased testicular size (HP:0008734)1.96111176
106Zonular cataract (HP:0010920)1.96056160
107Fetal akinesia sequence (HP:0001989)1.95297864
108Progressive inability to walk (HP:0002505)1.94103450
109Preaxial hand polydactyly (HP:0001177)1.94011523
110Osteomalacia (HP:0002749)1.92880285
111Oligodactyly (hands) (HP:0001180)1.91720332
112Absent eyebrow (HP:0002223)1.91183978
113Abnormal eating behavior (HP:0100738)1.90416223
114Hypoplastic iliac wings (HP:0002866)1.90238780
115Bony spicule pigmentary retinopathy (HP:0007737)1.89729344
116Abnormality of the renal cortex (HP:0011035)1.89453094
117Abnormality of the ileum (HP:0001549)1.89261875
118Pachygyria (HP:0001302)1.88872701
119Congenital stationary night blindness (HP:0007642)1.88462064
120Poor coordination (HP:0002370)1.88297925
121Impaired vibration sensation in the lower limbs (HP:0002166)1.87929846
122Congenital sensorineural hearing impairment (HP:0008527)1.87600809
123Choroideremia (HP:0001139)1.86146227
124Inability to walk (HP:0002540)1.85974716
125Dandy-Walker malformation (HP:0001305)1.85853520
126Aplasia/Hypoplasia of the lens (HP:0008063)1.85841388
127Aganglionic megacolon (HP:0002251)1.85476410
128Ectopic kidney (HP:0000086)1.85145067
129Polyphagia (HP:0002591)1.85080096
130Broad foot (HP:0001769)1.83594566
131Patellar aplasia (HP:0006443)1.83472182
132Neurofibrillary tangles (HP:0002185)1.83311260
133Depression (HP:0000716)1.82974593
134Preaxial foot polydactyly (HP:0001841)1.82876527
135Megalencephaly (HP:0001355)1.82748551
136Upper limb muscle weakness (HP:0003484)1.81826792
137Bradycardia (HP:0001662)1.81137859
138Dysdiadochokinesis (HP:0002075)1.81022016
139Facial hemangioma (HP:0000329)1.80614746
140Limb dystonia (HP:0002451)1.80453232
141Symptomatic seizures (HP:0011145)1.80383088
142Aplasia/Hypoplasia of the patella (HP:0006498)1.79803095
143Triphalangeal thumb (HP:0001199)1.78998032
144Ulnar claw (HP:0001178)1.78121293
145Genital tract atresia (HP:0001827)1.77826033
146Thyroid-stimulating hormone excess (HP:0002925)1.77692786
147Growth hormone deficiency (HP:0000824)1.77021431
148Hypoventilation (HP:0002791)1.75434699
149Astigmatism (HP:0000483)1.75088536
150Abnormality of midbrain morphology (HP:0002418)1.75029178
151Molar tooth sign on MRI (HP:0002419)1.75029178
152Meckel diverticulum (HP:0002245)1.73924035
153Hemivertebrae (HP:0002937)1.73455167
154Abnormality of the renal medulla (HP:0100957)1.73081868
155Progressive sensorineural hearing impairment (HP:0000408)1.71866900
156Male pseudohermaphroditism (HP:0000037)1.71833861
157Poor eye contact (HP:0000817)1.71211078
158Postural instability (HP:0002172)1.71107824
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69989035
160Vaginal atresia (HP:0000148)1.69921530
161Hyperkalemia (HP:0002153)1.69698151
162Sloping forehead (HP:0000340)1.69489613
163Anophthalmia (HP:0000528)1.69156974
164Cerebral inclusion bodies (HP:0100314)1.68201063
165Tubulointerstitial nephritis (HP:0001970)1.68048915
166Esotropia (HP:0000565)1.67847686
167Menstrual irregularities (HP:0000858)1.65956004
168Chronic hepatic failure (HP:0100626)1.65327454
169Optic nerve hypoplasia (HP:0000609)1.64717743
170Exotropia (HP:0000577)1.64704416
171Hyperinsulinemic hypoglycemia (HP:0000825)1.63776552
172Abnormality of renin-angiotensin system (HP:0000847)1.62309350
173Heterochromia iridis (HP:0001100)1.61654272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32243903
2CASK3.71184171
3EPHA43.53087830
4RIPK43.03112525
5WNK32.95540325
6MAP2K72.92188835
7NUAK12.76428993
8MAPK152.66793084
9MAP3K102.65789839
10MAP3K42.48540458
11MAP3K122.30956544
12STK38L2.15053321
13MAP4K22.13969032
14TNIK2.12981279
15CDC72.09549377
16BMPR22.04061163
17MARK11.87880365
18MINK11.86890925
19TRIM281.77889294
20DYRK21.73156301
21MAPK131.69352526
22SIK31.65276690
23MAP2K41.62278680
24ZAK1.62113242
25INSRR1.56479111
26PRPF4B1.48271365
27NTRK21.48053331
28GRK71.47349591
29SIK21.45191340
30UHMK11.43502641
31AKT31.42898031
32PRKD31.40845897
33CCNB11.39173452
34FGFR21.37948592
35GRK11.33744826
36ARAF1.33306472
37LATS11.31707872
38MAP3K91.31540862
39SRPK11.31156324
40PLK21.30518776
41PNCK1.28733869
42WEE11.25972294
43PIK3CG1.24106278
44BRSK21.23905781
45GRK51.23836302
46VRK11.23407117
47CAMK2A1.20286284
48CAMK2B1.19420213
49PRKCG1.18959629
50NME11.18628341
51DAPK11.18113793
52MAP3K131.16715334
53CDK51.15907827
54SGK21.15209044
55STK161.12143046
56MKNK11.10858914
57BRAF1.10616937
58CAMK1D1.10467839
59WNK41.09261050
60CSNK1G31.08306062
61TLK11.05709706
62JAK31.05460444
63PLK31.04853792
64CSNK1G21.01845776
65DAPK21.01721464
66ADRBK21.00872893
67SGK2231.00437415
68SGK4941.00437415
69CSNK1G11.00256906
70KSR10.94504522
71MKNK20.93953645
72YES10.91770400
73PINK10.91385131
74CSNK1A1L0.90851374
75NTRK10.89544481
76NEK10.88717869
77CAMKK20.87790519
78TNK20.87543016
79STK380.86534412
80PRKCE0.84861187
81PTK2B0.83917834
82MUSK0.83667544
83FES0.83018220
84PLK40.82947978
85ERBB30.82603068
86EPHB20.80427126
87DYRK30.80378719
88DYRK1A0.76956940
89BCKDK0.76942920
90PAK60.75295554
91SGK10.74425269
92NEK60.72975334
93WNK10.72201375
94CAMK2D0.70267973
95CAMK10.69804117
96TGFBR10.69443400
97PLK10.66408081
98CDK30.64884338
99FER0.64773154
100BMPR1B0.63807137
101PAK30.62882136
102SGK30.62740750
103CHEK20.62645563
104CAMKK10.61916077
105BUB10.61552221
106STK30.61071702
107CSNK1D0.60714224
108CDK190.59168480
109EPHA30.58105970
110TIE10.57986992
111TXK0.57870315
112ATM0.56920121
113ATR0.54583359
114OXSR10.54520005
115PKN10.54256763
116FGR0.53445629
117MST1R0.51502240
118BCR0.50763733
119FRK0.49687469
120IRAK10.48158822
121VRK20.47954694
122PRKCH0.44180013
123CSNK1A10.43811143
124CAMK2G0.43181339
125BRD40.42928592
126PRKCQ0.42916299
127PRKACA0.42277942
128MAPK100.42092711
129CAMK1G0.41291608
130PRKG10.41266999
131ADRBK10.40787952
132KSR20.40733066
133RAF10.40594815
134PDK10.40526398
135BRSK10.40454132
136PRKCZ0.40037791
137PHKG20.39811696
138PHKG10.39811696
139NEK20.39711230
140MARK30.39236481
141CDK80.38943886
142MARK20.38565385
143STK110.38181577
144CSNK1E0.36833692
145PRKCB0.34886484
146PRKCA0.34689373
147STK390.34029515
148SYK0.32099664
149MAP3K10.32024184
150PRKAA10.31618859
151TAOK30.30169298
152RPS6KA30.29743230

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74547050
2Fanconi anemia pathway_Homo sapiens_hsa034603.23626592
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96851962
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93341116
5Steroid biosynthesis_Homo sapiens_hsa001002.81370816
6GABAergic synapse_Homo sapiens_hsa047272.65924789
7Morphine addiction_Homo sapiens_hsa050322.64454201
8Circadian entrainment_Homo sapiens_hsa047132.63305152
9Synaptic vesicle cycle_Homo sapiens_hsa047212.62757837
10Homologous recombination_Homo sapiens_hsa034402.62716134
11Long-term potentiation_Homo sapiens_hsa047202.54106446
12Glutamatergic synapse_Homo sapiens_hsa047242.54073964
13Amphetamine addiction_Homo sapiens_hsa050312.51999908
14Taste transduction_Homo sapiens_hsa047422.45596268
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42763049
16Insulin secretion_Homo sapiens_hsa049112.41650557
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22583801
18Olfactory transduction_Homo sapiens_hsa047402.21370063
19RNA polymerase_Homo sapiens_hsa030202.13198985
20Salivary secretion_Homo sapiens_hsa049702.12027018
21Butanoate metabolism_Homo sapiens_hsa006502.08387473
22Serotonergic synapse_Homo sapiens_hsa047262.07125927
23Dopaminergic synapse_Homo sapiens_hsa047282.03496873
24Hedgehog signaling pathway_Homo sapiens_hsa043402.00129738
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89572667
26Calcium signaling pathway_Homo sapiens_hsa040201.85142396
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79361060
28Basal cell carcinoma_Homo sapiens_hsa052171.76381587
29Renin secretion_Homo sapiens_hsa049241.72490069
30Long-term depression_Homo sapiens_hsa047301.68092396
31Collecting duct acid secretion_Homo sapiens_hsa049661.65279387
32Tryptophan metabolism_Homo sapiens_hsa003801.60810144
33Non-homologous end-joining_Homo sapiens_hsa034501.60031312
34Cocaine addiction_Homo sapiens_hsa050301.58752360
35Basal transcription factors_Homo sapiens_hsa030221.57995872
36Cholinergic synapse_Homo sapiens_hsa047251.57911480
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55752558
38Type I diabetes mellitus_Homo sapiens_hsa049401.51123831
39Gastric acid secretion_Homo sapiens_hsa049711.50322778
40Phototransduction_Homo sapiens_hsa047441.49022600
41Nitrogen metabolism_Homo sapiens_hsa009101.44944787
42Oxytocin signaling pathway_Homo sapiens_hsa049211.34123125
43cAMP signaling pathway_Homo sapiens_hsa040241.33785647
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31668665
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22547253
46Vibrio cholerae infection_Homo sapiens_hsa051101.22002151
47Propanoate metabolism_Homo sapiens_hsa006401.19862616
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16870514
49Type II diabetes mellitus_Homo sapiens_hsa049301.13240623
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11823838
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11648715
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09228301
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08511865
54DNA replication_Homo sapiens_hsa030301.07616345
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07190234
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07133644
57Axon guidance_Homo sapiens_hsa043601.06661637
58Caffeine metabolism_Homo sapiens_hsa002321.06307663
59GnRH signaling pathway_Homo sapiens_hsa049121.04895889
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.04580036
61Hippo signaling pathway_Homo sapiens_hsa043901.02866992
62Linoleic acid metabolism_Homo sapiens_hsa005911.01045015
63RNA degradation_Homo sapiens_hsa030180.99844091
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99779529
65Pancreatic secretion_Homo sapiens_hsa049720.98822521
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96178500
67Cell cycle_Homo sapiens_hsa041100.95274378
68Spliceosome_Homo sapiens_hsa030400.94373058
69Selenocompound metabolism_Homo sapiens_hsa004500.93065911
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.92684902
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91908975
72Mismatch repair_Homo sapiens_hsa034300.91634263
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90992829
74* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89788826
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89664548
76Gap junction_Homo sapiens_hsa045400.88410530
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86186944
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84533166
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84505657
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83703403
81Melanogenesis_Homo sapiens_hsa049160.83417286
82Cardiac muscle contraction_Homo sapiens_hsa042600.81547430
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.80540380
84RNA transport_Homo sapiens_hsa030130.79082684
85Alzheimers disease_Homo sapiens_hsa050100.78729952
86ErbB signaling pathway_Homo sapiens_hsa040120.77297466
87TGF-beta signaling pathway_Homo sapiens_hsa043500.76162875
88Rheumatoid arthritis_Homo sapiens_hsa053230.75466252
89Dorso-ventral axis formation_Homo sapiens_hsa043200.74585526
90Estrogen signaling pathway_Homo sapiens_hsa049150.73927641
91Oxidative phosphorylation_Homo sapiens_hsa001900.73811870
92Lysine degradation_Homo sapiens_hsa003100.72256647
93African trypanosomiasis_Homo sapiens_hsa051430.71552055
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69185082
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68890994
96Base excision repair_Homo sapiens_hsa034100.68367637
97Fatty acid elongation_Homo sapiens_hsa000620.67944591
98Inositol phosphate metabolism_Homo sapiens_hsa005620.66029002
99mRNA surveillance pathway_Homo sapiens_hsa030150.65071737
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63870358
101Glucagon signaling pathway_Homo sapiens_hsa049220.63799160
102Circadian rhythm_Homo sapiens_hsa047100.62889583
103Ras signaling pathway_Homo sapiens_hsa040140.62790309
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62562416
105Nucleotide excision repair_Homo sapiens_hsa034200.60529649
106Histidine metabolism_Homo sapiens_hsa003400.59848342
107Thyroid hormone synthesis_Homo sapiens_hsa049180.59048084
108Retinol metabolism_Homo sapiens_hsa008300.58907990
109MAPK signaling pathway_Homo sapiens_hsa040100.56658479
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56548589
111Purine metabolism_Homo sapiens_hsa002300.55998244
112Regulation of autophagy_Homo sapiens_hsa041400.54661489
113Choline metabolism in cancer_Homo sapiens_hsa052310.54341488
114Wnt signaling pathway_Homo sapiens_hsa043100.53859763
115Mineral absorption_Homo sapiens_hsa049780.53577974
116Ether lipid metabolism_Homo sapiens_hsa005650.53209291
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52881475
118Chemical carcinogenesis_Homo sapiens_hsa052040.51560763
119Ovarian steroidogenesis_Homo sapiens_hsa049130.51156593
120Glioma_Homo sapiens_hsa052140.50733470
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.50685918
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47460900
123Phagosome_Homo sapiens_hsa041450.47323600
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46278190
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45402075
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44479154
127Dilated cardiomyopathy_Homo sapiens_hsa054140.43735954
128Rap1 signaling pathway_Homo sapiens_hsa040150.42906042
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.42721004
130* Metabolic pathways_Homo sapiens_hsa011000.41068406
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40642902
132Oocyte meiosis_Homo sapiens_hsa041140.40468935
133Peroxisome_Homo sapiens_hsa041460.39808457
134Sphingolipid metabolism_Homo sapiens_hsa006000.39305880
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39283815
136Tight junction_Homo sapiens_hsa045300.38776544
137Huntingtons disease_Homo sapiens_hsa050160.38639121
138Prion diseases_Homo sapiens_hsa050200.38029897
139Fat digestion and absorption_Homo sapiens_hsa049750.37883952
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37708648
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37527606
142Graft-versus-host disease_Homo sapiens_hsa053320.36230662
143One carbon pool by folate_Homo sapiens_hsa006700.34833538
144Alcoholism_Homo sapiens_hsa050340.34700655
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34298236
146Protein export_Homo sapiens_hsa030600.32974467
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.31673028
148Allograft rejection_Homo sapiens_hsa053300.29114190
149Parkinsons disease_Homo sapiens_hsa050120.27400147
150Chemokine signaling pathway_Homo sapiens_hsa040620.26618623
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26169197
152Salmonella infection_Homo sapiens_hsa051320.24828580
153Autoimmune thyroid disease_Homo sapiens_hsa053200.23793395
154Melanoma_Homo sapiens_hsa052180.23558023

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