NDRG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14310304
2synaptic vesicle maturation (GO:0016188)6.01179825
3synaptic vesicle exocytosis (GO:0016079)5.57193842
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.53634317
5locomotory exploration behavior (GO:0035641)5.44852760
6glutamate secretion (GO:0014047)5.30866475
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28668788
8vocalization behavior (GO:0071625)5.28459105
9regulation of synaptic vesicle exocytosis (GO:2000300)5.13230493
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.10952863
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.09153040
12regulation of glutamate receptor signaling pathway (GO:1900449)4.86642744
13neuronal action potential propagation (GO:0019227)4.85061683
14cerebellar granule cell differentiation (GO:0021707)4.69515483
15neurotransmitter secretion (GO:0007269)4.63840368
16protein localization to synapse (GO:0035418)4.59576398
17regulation of synaptic vesicle transport (GO:1902803)4.57504682
18regulation of synapse structural plasticity (GO:0051823)4.50490083
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.48675872
20regulation of neuronal synaptic plasticity (GO:0048168)4.45930487
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43501284
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32622049
23exploration behavior (GO:0035640)4.25923005
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20641495
25neuron cell-cell adhesion (GO:0007158)4.18585068
26neurotransmitter-gated ion channel clustering (GO:0072578)4.16940838
27synaptic transmission, glutamatergic (GO:0035249)4.12307857
28neuron-neuron synaptic transmission (GO:0007270)4.11978320
29gamma-aminobutyric acid transport (GO:0015812)4.06174755
30glutamate receptor signaling pathway (GO:0007215)3.95534211
31L-amino acid import (GO:0043092)3.94168171
32potassium ion homeostasis (GO:0055075)3.84663370
33proline transport (GO:0015824)3.83312429
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82944003
35long-term memory (GO:0007616)3.80462550
36cellular potassium ion homeostasis (GO:0030007)3.76888523
37layer formation in cerebral cortex (GO:0021819)3.72141569
38positive regulation of membrane potential (GO:0045838)3.71859671
39axon ensheathment in central nervous system (GO:0032291)3.69645546
40central nervous system myelination (GO:0022010)3.69645546
41neurotransmitter transport (GO:0006836)3.68201607
42potassium ion import (GO:0010107)3.67947751
43presynaptic membrane organization (GO:0097090)3.67538943
44cellular sodium ion homeostasis (GO:0006883)3.65857411
45regulation of synaptic plasticity (GO:0048167)3.64515670
46activation of protein kinase A activity (GO:0034199)3.64440593
47prepulse inhibition (GO:0060134)3.64401231
48amino acid import (GO:0043090)3.64257040
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63312776
50regulation of postsynaptic membrane potential (GO:0060078)3.61807594
51neuromuscular process controlling posture (GO:0050884)3.61084880
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.60467167
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.59715569
54positive regulation of dendritic spine development (GO:0060999)3.58037788
55regulation of synapse maturation (GO:0090128)3.58000816
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56057956
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.55382401
58neuromuscular process controlling balance (GO:0050885)3.54758136
59long-term synaptic potentiation (GO:0060291)3.50897742
60cell communication involved in cardiac conduction (GO:0086065)3.50123767
61regulation of dendritic spine morphogenesis (GO:0061001)3.48814185
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48024398
63regulation of neurotransmitter levels (GO:0001505)3.47706013
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.47637773
65positive regulation of neurotransmitter transport (GO:0051590)3.47304972
66presynaptic membrane assembly (GO:0097105)3.47183073
67cerebellar Purkinje cell differentiation (GO:0021702)3.46102948
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45660118
69sodium ion export (GO:0071436)3.44996316
70regulation of neurotransmitter secretion (GO:0046928)3.44490274
71transmission of nerve impulse (GO:0019226)3.43442609
72dendritic spine morphogenesis (GO:0060997)3.42908708
73detection of calcium ion (GO:0005513)3.42870009
74negative regulation of dendrite morphogenesis (GO:0050774)3.42241302
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40999456
76positive regulation of synapse maturation (GO:0090129)3.40596148
77membrane depolarization during action potential (GO:0086010)3.39774471
78striatum development (GO:0021756)3.39255172
79establishment of mitochondrion localization (GO:0051654)3.37285558
80cell migration in hindbrain (GO:0021535)3.32585804
81auditory behavior (GO:0031223)3.30900377
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.30747291
83positive regulation of neurotransmitter secretion (GO:0001956)3.29545041
84regulation of neurotransmitter transport (GO:0051588)3.28247166
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27551368
86behavioral response to cocaine (GO:0048148)3.26980009
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26554777
88response to auditory stimulus (GO:0010996)3.24763333
89membrane depolarization (GO:0051899)3.24749059
90axonal fasciculation (GO:0007413)3.23452362
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23258077
92synaptic vesicle endocytosis (GO:0048488)3.21137309
93regulation of vesicle fusion (GO:0031338)3.20735586
94glycine transport (GO:0015816)3.18326490
95negative regulation of dendrite development (GO:2000171)3.17810750
96membrane hyperpolarization (GO:0060081)3.17153628
97acidic amino acid transport (GO:0015800)3.14685992
98behavioral fear response (GO:0001662)3.13705815
99behavioral defense response (GO:0002209)3.13705815
100neurotransmitter uptake (GO:0001504)3.13579651
101vesicle transport along microtubule (GO:0047496)3.12712498
102neuronal ion channel clustering (GO:0045161)3.11993567
103regulation of voltage-gated calcium channel activity (GO:1901385)3.11808694
104response to histamine (GO:0034776)3.11654770
105synaptic transmission, dopaminergic (GO:0001963)3.11555099
106neuron recognition (GO:0008038)3.11439472
107positive regulation of synaptic transmission (GO:0050806)3.10655691
108cell differentiation in hindbrain (GO:0021533)3.08071940
109cell communication by electrical coupling (GO:0010644)3.07888597
110neuromuscular synaptic transmission (GO:0007274)3.07684214
111neuromuscular process (GO:0050905)3.07385236
112regulation of ARF protein signal transduction (GO:0032012)3.07368254
113synaptic transmission (GO:0007268)3.07292215
114learning (GO:0007612)3.06326037
115dendritic spine organization (GO:0097061)3.05904971
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04524199
117adult walking behavior (GO:0007628)3.03806826
118regulation of cell communication by electrical coupling (GO:0010649)3.03540969
119regulation of synaptic transmission (GO:0050804)3.02770136
120mating behavior (GO:0007617)3.01914506
121regulation of glutamate secretion (GO:0014048)3.01825881
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.01779484
123mechanosensory behavior (GO:0007638)3.00671369
124postsynaptic membrane organization (GO:0001941)2.99126220
125regulation of synaptic transmission, GABAergic (GO:0032228)2.98863126
126establishment of synaptic vesicle localization (GO:0097480)2.98807329
127synaptic vesicle transport (GO:0048489)2.98807329
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94110483
129fear response (GO:0042596)2.92739833
130regulation of dendritic spine development (GO:0060998)2.92647996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92842892
2GBX2_23144817_ChIP-Seq_PC3_Human3.59498417
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23015913
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17275104
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05262421
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.96221331
7REST_21632747_ChIP-Seq_MESCs_Mouse2.83515398
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77634096
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77634096
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71731003
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66304510
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58987674
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58328881
14DROSHA_22980978_ChIP-Seq_HELA_Human2.56498632
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54634082
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49300765
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.40620110
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.39101609
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26468835
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25266770
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.21306104
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.20562255
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17147662
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13034746
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03231957
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00531272
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95787099
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92900660
29AR_21572438_ChIP-Seq_LNCaP_Human1.85670664
30TAF15_26573619_Chip-Seq_HEK293_Human1.83743580
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80816002
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70856069
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69879754
34SMAD4_21799915_ChIP-Seq_A2780_Human1.67707311
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.67190044
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62511313
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54713815
38* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42822471
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37557593
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36165712
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36135901
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.35444171
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35186750
44P300_19829295_ChIP-Seq_ESCs_Human1.31207195
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29297827
46* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28845975
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.28075694
48ZNF274_21170338_ChIP-Seq_K562_Hela1.25760836
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.25753622
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.24891096
51AR_25329375_ChIP-Seq_VCAP_Human1.23448831
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22500806
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22237025
54STAT3_23295773_ChIP-Seq_U87_Human1.22146181
55AR_19668381_ChIP-Seq_PC3_Human1.22046251
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18542719
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16689609
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15556094
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15066466
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12954175
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.12063640
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11240556
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10571127
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10213055
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09338489
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08869600
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08044947
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07737445
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07692056
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07321426
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06376964
72TCF4_23295773_ChIP-Seq_U87_Human1.05972376
73KDM2B_26808549_Chip-Seq_K562_Human1.05490821
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.04436805
75* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04041009
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02303133
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.02148702
78AHR_22903824_ChIP-Seq_MCF-7_Human1.01458083
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01278582
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01224877
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.00733030
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.99904760
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99676371
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99445480
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99425255
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98786105
87RNF2_27304074_Chip-Seq_NSC_Mouse0.96318424
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.95993465
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95365726
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95213625
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.93966751
92RUNX2_22187159_ChIP-Seq_PCA_Human0.93684486
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92903506
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90194753
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89966493
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89882091
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.88362907
98IGF1R_20145208_ChIP-Seq_DFB_Human0.88361303
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.87805373
100* SMAD3_21741376_ChIP-Seq_HESCs_Human0.87786393
101RXR_22108803_ChIP-Seq_LS180_Human0.87187218
102* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86969257
103CTCF_27219007_Chip-Seq_Bcells_Human0.86216554
104JUN_21703547_ChIP-Seq_K562_Human0.86203271
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85038509
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84161836
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.83772443
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82917514
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82803227
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.82639160
111TP53_16413492_ChIP-PET_HCT116_Human0.82445077
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81593160
113DPY_21335234_ChIP-Seq_ESCs_Mouse0.79569037
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78389928
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78389928
116SOX9_26525672_Chip-Seq_HEART_Mouse0.78192379
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77549703
118OCT4_19829295_ChIP-Seq_ESCs_Human0.77187729
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76883140
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76638219
121* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76325130
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76140494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.48270080
2MP0003880_abnormal_central_pattern4.85560746
3MP0003635_abnormal_synaptic_transmissio4.19318945
4MP0002822_catalepsy4.18506883
5MP0004270_analgesia3.76412255
6MP0009745_abnormal_behavioral_response3.56955579
7MP0001968_abnormal_touch/_nociception3.39847315
8MP0002063_abnormal_learning/memory/cond3.35295890
9MP0009046_muscle_twitch3.34183618
10MP0002064_seizures3.26110292
11MP0002572_abnormal_emotion/affect_behav2.82383484
12MP0002272_abnormal_nervous_system2.73220735
13MP0002734_abnormal_mechanical_nocicepti2.70867117
14MP0002736_abnormal_nociception_after2.65992206
15MP0002735_abnormal_chemical_nociception2.58182029
16MP0005423_abnormal_somatic_nervous2.57588830
17MP0001486_abnormal_startle_reflex2.52069410
18MP0001501_abnormal_sleep_pattern2.28284130
19MP0002733_abnormal_thermal_nociception2.22424615
20MP0001970_abnormal_pain_threshold2.13463847
21MP0002067_abnormal_sensory_capabilities2.01713473
22MP0001440_abnormal_grooming_behavior2.00070916
23MP0008569_lethality_at_weaning1.91853951
24MP0004858_abnormal_nervous_system1.91349683
25MP0002909_abnormal_adrenal_gland1.84808402
26MP0005386_behavior/neurological_phenoty1.82820569
27MP0004924_abnormal_behavior1.82820569
28MP0003329_amyloid_beta_deposits1.80301317
29MP0004811_abnormal_neuron_physiology1.78581370
30MP0006276_abnormal_autonomic_nervous1.78187621
31MP0005646_abnormal_pituitary_gland1.76361470
32MP0009780_abnormal_chondrocyte_physiolo1.76090230
33MP0002184_abnormal_innervation1.72451098
34MP0002557_abnormal_social/conspecific_i1.67826103
35MP0001529_abnormal_vocalization1.62369345
36MP0001984_abnormal_olfaction1.60988625
37MP0003879_abnormal_hair_cell1.59722097
38MP0000955_abnormal_spinal_cord1.48373952
39MP0000778_abnormal_nervous_system1.43858041
40MP0002066_abnormal_motor_capabilities/c1.40712674
41MP0003787_abnormal_imprinting1.37666273
42MP0003633_abnormal_nervous_system1.36959205
43MP0002882_abnormal_neuron_morphology1.32503472
44MP0001905_abnormal_dopamine_level1.28936526
45MP0002638_abnormal_pupillary_reflex1.25360263
46MP0004142_abnormal_muscle_tone1.25183837
47MP0000751_myopathy1.24090103
48MP0003123_paternal_imprinting1.23829789
49MP0004885_abnormal_endolymph1.17709257
50MP0008872_abnormal_physiological_respon1.16000656
51MP0003631_nervous_system_phenotype1.13250076
52MP0003122_maternal_imprinting1.11757896
53MP0001502_abnormal_circadian_rhythm1.10352635
54MP0008874_decreased_physiological_sensi1.07214920
55MP0001188_hyperpigmentation1.05225096
56MP0005645_abnormal_hypothalamus_physiol1.02562478
57MP0000013_abnormal_adipose_tissue1.01510706
58MP0002837_dystrophic_cardiac_calcinosis0.97399134
59MP0002152_abnormal_brain_morphology0.96089505
60MP0002229_neurodegeneration0.95611166
61MP0004085_abnormal_heartbeat0.94495287
62MP0002069_abnormal_eating/drinking_beha0.90584125
63MP0001177_atelectasis0.87465731
64MP0004145_abnormal_muscle_electrophysio0.87273142
65MP0005535_abnormal_body_temperature0.87133810
66MP0003075_altered_response_to0.86523052
67MP0010386_abnormal_urinary_bladder0.83597728
68MP0003121_genomic_imprinting0.83502816
69MP0004215_abnormal_myocardial_fiber0.82854791
70MP0000569_abnormal_digit_pigmentation0.82427718
71MP0000604_amyloidosis0.81248965
72MP0008961_abnormal_basal_metabolism0.77359221
73MP0001348_abnormal_lacrimal_gland0.76602627
74MP0003634_abnormal_glial_cell0.74892372
75MP0003690_abnormal_glial_cell0.74521578
76MP0008877_abnormal_DNA_methylation0.72997557
77MP0004147_increased_porphyrin_level0.72910733
78MP0003632_abnormal_nervous_system0.72586247
79MP0004484_altered_response_of0.70985788
80MP0005394_taste/olfaction_phenotype0.70800696
81MP0005499_abnormal_olfactory_system0.70800696
82MP0003283_abnormal_digestive_organ0.70606525
83MP0001963_abnormal_hearing_physiology0.70348173
84MP0004130_abnormal_muscle_cell0.70014620
85MP0000920_abnormal_myelination0.69831858
86MP0005551_abnormal_eye_electrophysiolog0.69261841
87MP0004742_abnormal_vestibular_system0.69066112
88MP0003137_abnormal_impulse_conducting0.68500206
89MP0004233_abnormal_muscle_weight0.65985037
90MP0005167_abnormal_blood-brain_barrier0.65847732
91MP0002090_abnormal_vision0.64611774
92MP0002752_abnormal_somatic_nervous0.64354419
93MP0003646_muscle_fatigue0.63514613
94MP0005409_darkened_coat_color0.63043466
95MP0001664_abnormal_digestion0.62782558
96MP0004084_abnormal_cardiac_muscle0.61615074
97MP0003861_abnormal_nervous_system0.61610035
98MP0000026_abnormal_inner_ear0.61032823
99MP0002876_abnormal_thyroid_physiology0.59252901
100MP0010769_abnormal_survival0.58621834
101MP0005623_abnormal_meninges_morphology0.57208142
102MP0001485_abnormal_pinna_reflex0.56567686
103MP0001986_abnormal_taste_sensitivity0.55564821
104MP0010768_mortality/aging0.55437424
105MP0002082_postnatal_lethality0.55261713
106MP0010770_preweaning_lethality0.55261713
107MP0010234_abnormal_vibrissa_follicle0.53946205
108MP0001943_abnormal_respiration0.52902270
109MP0000631_abnormal_neuroendocrine_gland0.52708841
110MP0004036_abnormal_muscle_relaxation0.51519335
111MP0001299_abnormal_eye_distance/0.50695635
112MP0004043_abnormal_pH_regulation0.50409648
113MP0004510_myositis0.50073643
114MP0003956_abnormal_body_size0.48994964

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.22975797
2Myokymia (HP:0002411)7.74067022
3Focal seizures (HP:0007359)6.04536578
4Visual hallucinations (HP:0002367)5.09321770
5Atonic seizures (HP:0010819)4.91191576
6Epileptic encephalopathy (HP:0200134)4.89310641
7Febrile seizures (HP:0002373)4.70104459
8Absence seizures (HP:0002121)4.26774905
9Progressive cerebellar ataxia (HP:0002073)4.24149619
10Action tremor (HP:0002345)4.22638007
11Generalized tonic-clonic seizures (HP:0002069)3.99912925
12Dialeptic seizures (HP:0011146)3.92031343
13Ankle clonus (HP:0011448)3.58545721
14Poor eye contact (HP:0000817)3.53085381
15Gaze-evoked nystagmus (HP:0000640)3.51333058
16Impaired vibration sensation in the lower limbs (HP:0002166)3.50063426
17Broad-based gait (HP:0002136)3.43869700
18Supranuclear gaze palsy (HP:0000605)3.40422563
19Depression (HP:0000716)3.39101934
20Dysdiadochokinesis (HP:0002075)3.28225100
21Impaired social interactions (HP:0000735)3.25657972
22Abnormal social behavior (HP:0012433)3.25657972
23Anxiety (HP:0000739)3.22589362
24Urinary bladder sphincter dysfunction (HP:0002839)3.18143625
25Truncal ataxia (HP:0002078)3.16953880
26Hyperventilation (HP:0002883)3.15609027
27Abnormal eating behavior (HP:0100738)3.07821576
28Dysmetria (HP:0001310)3.04489110
29Cerebral hypomyelination (HP:0006808)3.01843628
30Torticollis (HP:0000473)3.00046898
31Postural instability (HP:0002172)2.99624765
32Amblyopia (HP:0000646)2.85972150
33Pheochromocytoma (HP:0002666)2.85698012
34Urinary urgency (HP:0000012)2.85466758
35Abnormality of the lower motor neuron (HP:0002366)2.84723393
36Scanning speech (HP:0002168)2.84090295
37Annular pancreas (HP:0001734)2.81158928
38Tetraplegia (HP:0002445)2.80523050
39Dysmetric saccades (HP:0000641)2.78355288
40Focal dystonia (HP:0004373)2.76984145
41Progressive inability to walk (HP:0002505)2.71709851
42Mutism (HP:0002300)2.71231954
43Papilledema (HP:0001085)2.70141441
44Impaired smooth pursuit (HP:0007772)2.69299352
45Obstructive sleep apnea (HP:0002870)2.66117633
46Akinesia (HP:0002304)2.63733488
47Spastic gait (HP:0002064)2.61750883
48Ventricular fibrillation (HP:0001663)2.60569585
49Bradykinesia (HP:0002067)2.56792156
50Termporal pattern (HP:0011008)2.56154071
51Insidious onset (HP:0003587)2.56154071
52Craniofacial dystonia (HP:0012179)2.54469653
53Resting tremor (HP:0002322)2.53706272
54Peripheral hypomyelination (HP:0007182)2.53148167
55Neuroendocrine neoplasm (HP:0100634)2.49770093
56Sudden death (HP:0001699)2.49218800
57Limb dystonia (HP:0002451)2.48361636
58Genetic anticipation (HP:0003743)2.47723693
59Stereotypic behavior (HP:0000733)2.47028328
60Status epilepticus (HP:0002133)2.44795277
61Sleep apnea (HP:0010535)2.44023305
62Hemiplegia (HP:0002301)2.41988576
63Epileptiform EEG discharges (HP:0011182)2.41974159
64Impaired vibratory sensation (HP:0002495)2.40724418
65Syncope (HP:0001279)2.34339066
66Abnormality of ocular smooth pursuit (HP:0000617)2.33336030
67Fetal akinesia sequence (HP:0001989)2.32588291
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32260718
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.32260718
70Intention tremor (HP:0002080)2.31382272
71EEG with generalized epileptiform discharges (HP:0011198)2.30980858
72Excessive salivation (HP:0003781)2.30342217
73Drooling (HP:0002307)2.30342217
74Morphological abnormality of the pyramidal tract (HP:0002062)2.27984207
75Apathy (HP:0000741)2.26066204
76Hemiparesis (HP:0001269)2.25649913
77Hypsarrhythmia (HP:0002521)2.21827076
78Abnormality of binocular vision (HP:0011514)2.21519899
79Diplopia (HP:0000651)2.21519899
80Inability to walk (HP:0002540)2.19212116
81Lower limb muscle weakness (HP:0007340)2.19059187
82Pointed chin (HP:0000307)2.14405183
83Amyotrophic lateral sclerosis (HP:0007354)2.12609454
84Heart block (HP:0012722)2.10006304
85Insomnia (HP:0100785)2.09073933
86Incomplete penetrance (HP:0003829)2.07007789
87Absent speech (HP:0001344)2.06797341
88Abnormality of the corticospinal tract (HP:0002492)2.06511076
89Diminished motivation (HP:0000745)2.05068453
90Spastic tetraparesis (HP:0001285)2.04388653
91Bundle branch block (HP:0011710)2.03217781
92Generalized myoclonic seizures (HP:0002123)2.02872748
93CNS hypomyelination (HP:0003429)2.02329369
94Failure to thrive in infancy (HP:0001531)2.02139176
95Abnormal EKG (HP:0003115)2.01001928
96Gait ataxia (HP:0002066)2.00665946
97Neoplasm of the peripheral nervous system (HP:0100007)2.00107258
98Polyphagia (HP:0002591)1.99522098
99Primary atrial arrhythmia (HP:0001692)1.98713199
100Cerebral inclusion bodies (HP:0100314)1.98579101
101Megalencephaly (HP:0001355)1.98316018
102Impaired pain sensation (HP:0007328)1.95264115
103Abnormality of pain sensation (HP:0010832)1.95264115
104Abnormality of saccadic eye movements (HP:0000570)1.95042529
105Neurofibrillary tangles (HP:0002185)1.95026790
106Atrial fibrillation (HP:0005110)1.94483343
107Clonus (HP:0002169)1.94230354
108Lower limb amyotrophy (HP:0007210)1.93849486
109Supraventricular tachycardia (HP:0004755)1.89497747
110Spastic tetraplegia (HP:0002510)1.88929487
111Neuronal loss in central nervous system (HP:0002529)1.88761636
112Rigidity (HP:0002063)1.87523898
113Lower limb asymmetry (HP:0100559)1.85327978
114Hypoventilation (HP:0002791)1.85271209
115Prolonged QT interval (HP:0001657)1.85221335
116Delusions (HP:0000746)1.83640063
117Spinal canal stenosis (HP:0003416)1.83451507
118Blue irides (HP:0000635)1.82382233
119Rapidly progressive (HP:0003678)1.79670602
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79447938
121Psychosis (HP:0000709)1.79389819
122Specific learning disability (HP:0001328)1.74579874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.71164854
2NTRK34.62685837
3MAP3K93.98621100
4MAP3K43.02490377
5MINK12.79852772
6DAPK22.63531892
7MAP2K72.54515695
8KSR22.47027603
9MAP3K122.22287729
10MARK12.13549443
11PAK62.12715734
12NTRK12.08647582
13RIPK42.06353744
14MAP2K41.97713767
15CAMKK11.93841111
16CASK1.87040319
17PRKD31.86258786
18ARAF1.80557773
19NTRK21.78363701
20DAPK11.67216019
21KSR11.62858259
22CDK51.54720105
23CDK191.51807625
24CAMKK21.41516517
25GRK51.37366568
26RIPK11.37201586
27MAP3K131.35297902
28PLK21.32019653
29FES1.31138892
30STK381.30430915
31MAP3K21.29630532
32PRPF4B1.25975383
33TNIK1.24836657
34LMTK21.20224988
35PRKCG1.19310156
36TAOK11.09968040
37MAPK131.07744273
38SIK21.02677927
39SGK2231.02509556
40SGK4941.02509556
41LATS21.00941076
42UHMK10.97357449
43TYRO30.96746850
44CAMK2A0.94121608
45PINK10.93843125
46CDK180.93762367
47PNCK0.92327325
48RAF10.91914990
49SGK20.91116728
50RET0.90664687
51PHKG20.90083425
52PHKG10.90083425
53CDK150.90006796
54CDK140.89267777
55CAMK10.87821719
56PKN10.87473679
57NEK10.87249700
58PRKCH0.86674656
59MAPK120.82241753
60PTK2B0.79389571
61SGK30.78544605
62STK110.78276023
63LIMK10.78027909
64CDK11A0.77759786
65MAP3K10.74975578
66CAMK2B0.74720342
67OXSR10.74088137
68PDK10.72023447
69PDPK10.69212220
70BMPR20.67345186
71TNK20.66640992
72SGK10.64419606
73ALK0.63983264
74ROCK20.63401360
75BCR0.62753342
76PAK30.60687543
77DYRK20.59507840
78MAP2K10.58775910
79WNK10.58431599
80SIK30.57017609
81CCNB10.56164482
82MARK20.52881566
83BRAF0.51162787
84CSNK1G20.50588202
85FER0.50438384
86PRKCE0.49885304
87CAMK2G0.49778125
88DAPK30.48772087
89FGFR20.47750367
90DYRK1A0.47635733
91CAMK2D0.47446154
92RPS6KA30.46950829
93PDK30.46879507
94PDK40.46879507
95SCYL20.46597282
96CSNK1G30.46306945
97AKT30.45228889
98CDC42BPA0.44477944
99CAMK40.43929733
100PRKCZ0.43320103
101TESK10.42470825
102ROCK10.41557573
103DMPK0.40955024
104CSNK1A1L0.40483452
105MAPK100.40315643
106BRSK10.39701895
107NEK60.39672901
108FYN0.38809608
109PRKACA0.35478987
110RPS6KA20.35093292
111MAP3K110.35032953
112PRKG10.34943278
113MAPKAPK50.34495462
114DYRK1B0.33936734
115MAP3K70.33240916
116NME10.32729164
117PRKD10.32461765
118PRKAA10.32299115
119PRKCA0.32118609
120ERBB20.31868147
121MUSK0.31572475
122PRKCB0.30839133
123MAPK80.28874650

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.59655582
2Nicotine addiction_Homo sapiens_hsa050333.54363105
3Olfactory transduction_Homo sapiens_hsa047403.01577340
4GABAergic synapse_Homo sapiens_hsa047272.68351505
5Circadian entrainment_Homo sapiens_hsa047132.66423099
6Long-term potentiation_Homo sapiens_hsa047202.65540628
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58793808
8Morphine addiction_Homo sapiens_hsa050322.52989811
9Amphetamine addiction_Homo sapiens_hsa050312.51954345
10Glutamatergic synapse_Homo sapiens_hsa047242.44047875
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26581444
12Dopaminergic synapse_Homo sapiens_hsa047282.23203116
13Salivary secretion_Homo sapiens_hsa049702.12899688
14Insulin secretion_Homo sapiens_hsa049111.97251638
15Cholinergic synapse_Homo sapiens_hsa047251.92518960
16Gastric acid secretion_Homo sapiens_hsa049711.85923085
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78960844
18Cocaine addiction_Homo sapiens_hsa050301.76712650
19Taste transduction_Homo sapiens_hsa047421.75904816
20Collecting duct acid secretion_Homo sapiens_hsa049661.71010373
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70848123
22Renin secretion_Homo sapiens_hsa049241.69601700
23Oxytocin signaling pathway_Homo sapiens_hsa049211.63900272
24Long-term depression_Homo sapiens_hsa047301.63664808
25Calcium signaling pathway_Homo sapiens_hsa040201.60268620
26Serotonergic synapse_Homo sapiens_hsa047261.58579677
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55759989
28GnRH signaling pathway_Homo sapiens_hsa049121.43941767
29Gap junction_Homo sapiens_hsa045401.37780863
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36792401
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35889479
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30738349
33cAMP signaling pathway_Homo sapiens_hsa040241.25708754
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16097568
35Type II diabetes mellitus_Homo sapiens_hsa049301.10832443
36Estrogen signaling pathway_Homo sapiens_hsa049151.10395896
37Glioma_Homo sapiens_hsa052141.10143364
38Cardiac muscle contraction_Homo sapiens_hsa042601.07453496
39Vitamin B6 metabolism_Homo sapiens_hsa007501.06909106
40Vibrio cholerae infection_Homo sapiens_hsa051101.04684360
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00052462
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98567499
43ErbB signaling pathway_Homo sapiens_hsa040120.96929607
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96794295
45Melanogenesis_Homo sapiens_hsa049160.94717331
46Nitrogen metabolism_Homo sapiens_hsa009100.93466381
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.92029067
48Oocyte meiosis_Homo sapiens_hsa041140.90538198
49Axon guidance_Homo sapiens_hsa043600.86126037
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84700808
51Dorso-ventral axis formation_Homo sapiens_hsa043200.81902134
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80323109
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80043633
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.79498485
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79103498
56Pancreatic secretion_Homo sapiens_hsa049720.78105646
57Phototransduction_Homo sapiens_hsa047440.75083772
58Dilated cardiomyopathy_Homo sapiens_hsa054140.73588788
59Thyroid hormone synthesis_Homo sapiens_hsa049180.73274868
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.66736846
61MAPK signaling pathway_Homo sapiens_hsa040100.66242708
62Choline metabolism in cancer_Homo sapiens_hsa052310.63214424
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61048293
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60879028
65Glucagon signaling pathway_Homo sapiens_hsa049220.60539294
66Type I diabetes mellitus_Homo sapiens_hsa049400.59244352
67VEGF signaling pathway_Homo sapiens_hsa043700.58233184
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57919366
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54317060
70Rap1 signaling pathway_Homo sapiens_hsa040150.54284744
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53235061
72Alcoholism_Homo sapiens_hsa050340.52659816
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52467687
74Ras signaling pathway_Homo sapiens_hsa040140.51873044
75Arginine and proline metabolism_Homo sapiens_hsa003300.49796941
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49602930
77Inositol phosphate metabolism_Homo sapiens_hsa005620.48807071
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.48181119
79Endocytosis_Homo sapiens_hsa041440.47854429
80Bile secretion_Homo sapiens_hsa049760.47504067
81mTOR signaling pathway_Homo sapiens_hsa041500.46932684
82Alzheimers disease_Homo sapiens_hsa050100.46607534
83Non-small cell lung cancer_Homo sapiens_hsa052230.45386297
84Insulin signaling pathway_Homo sapiens_hsa049100.44042414
85Circadian rhythm_Homo sapiens_hsa047100.42642955
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41355173
87Prion diseases_Homo sapiens_hsa050200.39575853
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39376136
89Endometrial cancer_Homo sapiens_hsa052130.38085676
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37988389
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37830505
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36488747
93Arginine biosynthesis_Homo sapiens_hsa002200.36040999
94Parkinsons disease_Homo sapiens_hsa050120.35151338
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35037422
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33512544
97AMPK signaling pathway_Homo sapiens_hsa041520.33424092
98Tight junction_Homo sapiens_hsa045300.33237332
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32149488
100Oxidative phosphorylation_Homo sapiens_hsa001900.31977255
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31734254
102Chemokine signaling pathway_Homo sapiens_hsa040620.30789647
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29727316
104African trypanosomiasis_Homo sapiens_hsa051430.29725109
105Renal cell carcinoma_Homo sapiens_hsa052110.28856614
106Fatty acid biosynthesis_Homo sapiens_hsa000610.27271933
107Hippo signaling pathway_Homo sapiens_hsa043900.26525842
108Wnt signaling pathway_Homo sapiens_hsa043100.26124084
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25336315
110Ovarian steroidogenesis_Homo sapiens_hsa049130.24965996
111Regulation of autophagy_Homo sapiens_hsa041400.24306824
112beta-Alanine metabolism_Homo sapiens_hsa004100.22095165
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22028415

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