NDRG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.75156414
2glutamate secretion (GO:0014047)5.97181463
3synaptic vesicle exocytosis (GO:0016079)5.63226187
4regulation of synaptic vesicle exocytosis (GO:2000300)5.40335798
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27719686
6L-amino acid import (GO:0043092)5.12963454
7central nervous system myelination (GO:0022010)5.06057407
8axon ensheathment in central nervous system (GO:0032291)5.06057407
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01308497
10regulation of synaptic vesicle transport (GO:1902803)4.77110128
11neurotransmitter secretion (GO:0007269)4.70023433
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62000989
13L-phenylalanine catabolic process (GO:0006559)4.62000989
14cerebellar granule cell differentiation (GO:0021707)4.59812505
15potassium ion homeostasis (GO:0055075)4.59431072
16alpha-linolenic acid metabolic process (GO:0036109)4.59415509
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59378854
18amino acid import (GO:0043090)4.56707410
19neuronal action potential propagation (GO:0019227)4.53583300
20positive regulation of synapse maturation (GO:0090129)4.50173165
21postsynaptic membrane organization (GO:0001941)4.49472314
22L-phenylalanine metabolic process (GO:0006558)4.41118685
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.41118685
24regulation of neuronal synaptic plasticity (GO:0048168)4.36911750
25vocalization behavior (GO:0071625)4.25619074
26dicarboxylic acid biosynthetic process (GO:0043650)4.20936274
27cellular sodium ion homeostasis (GO:0006883)4.08345061
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.05455954
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04583878
30aromatic amino acid family catabolic process (GO:0009074)4.00706568
31lysine catabolic process (GO:0006554)3.96040018
32lysine metabolic process (GO:0006553)3.96040018
33neurotransmitter uptake (GO:0001504)3.94983897
34glutamate metabolic process (GO:0006536)3.93568590
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90787857
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90384941
37kynurenine metabolic process (GO:0070189)3.89649539
38exploration behavior (GO:0035640)3.89428394
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.86900850
40neurotransmitter transport (GO:0006836)3.84867198
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80338210
42bile acid biosynthetic process (GO:0006699)3.78242641
43cellular ketone body metabolic process (GO:0046950)3.75766715
44aspartate family amino acid catabolic process (GO:0009068)3.73329249
45regulation of synapse maturation (GO:0090128)3.69646760
46neuronal ion channel clustering (GO:0045161)3.68801544
47glyoxylate metabolic process (GO:0046487)3.68746935
48high-density lipoprotein particle remodeling (GO:0034375)3.67937076
49regulation of neurotransmitter levels (GO:0001505)3.65329390
50regulation of synapse structural plasticity (GO:0051823)3.64589174
51regulation of glutamate receptor signaling pathway (GO:1900449)3.60419169
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59469521
53regulation of voltage-gated calcium channel activity (GO:1901385)3.58309055
54positive regulation of dendritic spine development (GO:0060999)3.57529448
55sulfur amino acid catabolic process (GO:0000098)3.57208148
56dicarboxylic acid catabolic process (GO:0043649)3.55913114
57tryptophan catabolic process (GO:0006569)3.54942882
58indole-containing compound catabolic process (GO:0042436)3.54942882
59indolalkylamine catabolic process (GO:0046218)3.54942882
60neuromuscular process controlling balance (GO:0050885)3.54653054
61regulation of cholesterol esterification (GO:0010872)3.51223592
62reverse cholesterol transport (GO:0043691)3.48983374
632-oxoglutarate metabolic process (GO:0006103)3.48847637
64neuron cell-cell adhesion (GO:0007158)3.48385988
65short-chain fatty acid metabolic process (GO:0046459)3.46506115
66cellular modified amino acid catabolic process (GO:0042219)3.43402631
67cysteine metabolic process (GO:0006534)3.42046591
68regulation of cell communication by electrical coupling (GO:0010649)3.41024678
69regulation of triglyceride catabolic process (GO:0010896)3.40925949
70low-density lipoprotein particle remodeling (GO:0034374)3.39236045
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39029504
72regulation of ARF protein signal transduction (GO:0032012)3.38842908
73synaptic transmission, glutamatergic (GO:0035249)3.38232026
74alpha-amino acid catabolic process (GO:1901606)3.37614647
75macromolecular complex remodeling (GO:0034367)3.36636544
76plasma lipoprotein particle remodeling (GO:0034369)3.36636544
77protein-lipid complex remodeling (GO:0034368)3.36636544
78positive regulation of membrane potential (GO:0045838)3.35646481
79regulation of synaptic plasticity (GO:0048167)3.34353030
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33054007
81acidic amino acid transport (GO:0015800)3.32509614
82urea cycle (GO:0000050)3.32010102
83urea metabolic process (GO:0019627)3.32010102
84amino-acid betaine metabolic process (GO:0006577)3.31447239
85regulation of neurotransmitter secretion (GO:0046928)3.31020595
86gamma-aminobutyric acid transport (GO:0015812)3.29109827
87tryptophan metabolic process (GO:0006568)3.27077237
88positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26594482
89cellular amino acid catabolic process (GO:0009063)3.26182912
90dendritic spine morphogenesis (GO:0060997)3.25610921
91cell communication involved in cardiac conduction (GO:0086065)3.24301661
92ketone body metabolic process (GO:1902224)3.23673057
93auditory behavior (GO:0031223)3.23620476
94serine family amino acid catabolic process (GO:0009071)3.23318385
95regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23315415
96protein localization to synapse (GO:0035418)3.22924068
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22697035
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20065319
99negative regulation of fibrinolysis (GO:0051918)3.19926826
100homocysteine metabolic process (GO:0050667)3.17373396
101bile acid metabolic process (GO:0008206)3.15522171
102regulation of neurotransmitter transport (GO:0051588)3.12750029
103membrane depolarization during action potential (GO:0086010)3.12383190
104regulation of protein activation cascade (GO:2000257)3.11027684
105complement activation, alternative pathway (GO:0006957)3.09335607
106synaptic vesicle endocytosis (GO:0048488)3.09091219
107gamma-aminobutyric acid signaling pathway (GO:0007214)3.08513112
108ethanol oxidation (GO:0006069)3.05000149
109nitrogen cycle metabolic process (GO:0071941)3.04373903
110neuron-neuron synaptic transmission (GO:0007270)3.04297593
111positive regulation of fatty acid beta-oxidation (GO:0032000)3.03617030
112cerebellar Purkinje cell differentiation (GO:0021702)3.03359599
113glutamate receptor signaling pathway (GO:0007215)3.03298729
114coenzyme catabolic process (GO:0009109)3.02933738
115acetyl-CoA metabolic process (GO:0006084)3.02895411
116regulation of fibrinolysis (GO:0051917)3.02872411
117regulation of dendritic spine development (GO:0060998)3.01169485
118neuromuscular synaptic transmission (GO:0007274)3.00990135
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00752238
120cell communication by electrical coupling (GO:0010644)2.99881143
121long-term memory (GO:0007616)2.99756700
122activation of protein kinase A activity (GO:0034199)2.99212657
123fatty acid transmembrane transport (GO:1902001)2.97320958
124phospholipid efflux (GO:0033700)2.96783772
125regulation of postsynaptic membrane potential (GO:0060078)2.96401430
126negative regulation of cholesterol transport (GO:0032375)2.95635175
127negative regulation of sterol transport (GO:0032372)2.95635175
128protein carboxylation (GO:0018214)2.95582129
129peptidyl-glutamic acid carboxylation (GO:0017187)2.95582129
130regulation of female receptivity (GO:0045924)2.95260587
131sodium ion export (GO:0071436)2.95229544
132C4-dicarboxylate transport (GO:0015740)2.94936758
133alanine transport (GO:0032328)2.93333262
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93118628
135regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.92871900
136regulation of dendritic spine morphogenesis (GO:0061001)2.92783523
137regulation of vesicle fusion (GO:0031338)2.92638542
138L-glutamate transport (GO:0015813)2.92259368
139presynaptic membrane organization (GO:0097090)2.91581655
140sarcoplasmic reticulum calcium ion transport (GO:0070296)2.90149671
141carnitine shuttle (GO:0006853)2.90119750
142regulation of complement activation (GO:0030449)2.90004138
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.89759873
144regulation of cholesterol homeostasis (GO:2000188)2.88860832
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88271347
146fatty acid beta-oxidation (GO:0006635)2.87746061
147positive regulation of fatty acid oxidation (GO:0046321)2.87151570
148glutamine family amino acid catabolic process (GO:0009065)2.86833300
149detection of calcium ion (GO:0005513)2.86227809
150regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.85158257
151cellular potassium ion homeostasis (GO:0030007)2.84901125
152locomotory exploration behavior (GO:0035641)2.83996618
153presynaptic membrane assembly (GO:0097105)2.83931707
154linoleic acid metabolic process (GO:0043651)2.83901513
155organic acid catabolic process (GO:0016054)2.83524775
156carboxylic acid catabolic process (GO:0046395)2.83524775
157positive regulation of lipid catabolic process (GO:0050996)2.83243056
158monocarboxylic acid catabolic process (GO:0072329)2.82783449
159layer formation in cerebral cortex (GO:0021819)2.82222414
160triglyceride homeostasis (GO:0070328)2.82213799
161acylglycerol homeostasis (GO:0055090)2.82213799
162long-term synaptic potentiation (GO:0060291)2.82117925
163regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81490925
164membrane depolarization (GO:0051899)2.81439090
165aromatic amino acid family metabolic process (GO:0009072)2.81030482
166phospholipid homeostasis (GO:0055091)2.79953512
167succinate metabolic process (GO:0006105)2.77042710
168neurotransmitter-gated ion channel clustering (GO:0072578)2.76288014
169regulation of synaptic transmission (GO:0050804)2.76209455
170regulation of bile acid biosynthetic process (GO:0070857)2.75161905
171carnitine metabolic process (GO:0009437)2.74692875
172synaptic vesicle maturation (GO:0016188)2.74624824
173proline transport (GO:0015824)2.74541705
174drug catabolic process (GO:0042737)2.74136362
175regulation of actin filament-based movement (GO:1903115)2.74107995
176lipid oxidation (GO:0034440)2.72805597
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72692112
178positive regulation of neurotransmitter transport (GO:0051590)2.71736900
179positive regulation of dendrite development (GO:1900006)2.71503722
180plasma lipoprotein particle clearance (GO:0034381)2.71237021
181fatty acid oxidation (GO:0019395)2.70765391
182fatty acid catabolic process (GO:0009062)2.69582879
183glycogen catabolic process (GO:0005980)2.68680315
184regulation of fatty acid beta-oxidation (GO:0031998)2.67662690
185potassium ion import (GO:0010107)2.67421317
186tyrosine metabolic process (GO:0006570)2.67293980
187cellular glucuronidation (GO:0052695)2.66877936
188arginine metabolic process (GO:0006525)2.66243998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.08914002
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.21419377
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.53010375
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50450065
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.45938887
6EZH2_22144423_ChIP-Seq_EOC_Human3.08236441
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06621414
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.56744324
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51957447
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13064047
11* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96361244
12DROSHA_22980978_ChIP-Seq_HELA_Human1.92574398
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91936727
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82092366
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81620548
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81082846
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78423411
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78423411
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74213008
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67306830
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66803531
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64535825
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63586042
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62615348
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.62523363
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.57491935
27REST_21632747_ChIP-Seq_MESCs_Mouse1.55809073
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54108829
29GBX2_23144817_ChIP-Seq_PC3_Human1.49802448
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.49156558
31AR_21572438_ChIP-Seq_LNCaP_Human1.46627849
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.45571348
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43874199
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41986111
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41904188
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.41063015
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40484619
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37180764
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.33588004
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32964140
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30295298
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.30291982
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.29030807
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.26999570
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25693323
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25409867
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25393752
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.23219906
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21399510
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20138255
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19196643
52TET1_21490601_ChIP-Seq_MESCs_Mouse1.15588570
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15406996
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13235393
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.11248537
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10781306
57HTT_18923047_ChIP-ChIP_STHdh_Human1.10760639
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10676560
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09552548
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09208819
61SMC4_20622854_ChIP-Seq_HELA_Human1.04023342
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03786611
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02808760
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02298721
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.02189947
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00300913
67RING1B_27294783_Chip-Seq_NPCs_Mouse0.99780081
68NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98966748
69OCT4_19829295_ChIP-Seq_ESCs_Human0.98568351
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98025533
71ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97575398
72SOX2_21211035_ChIP-Seq_LN229_Gbm0.95405173
73BCAT_22108803_ChIP-Seq_LS180_Human0.94483813
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94002342
75* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93971995
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93343222
77WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92382528
78CLOCK_20551151_ChIP-Seq_293T_Human0.91676443
79RING1B_27294783_Chip-Seq_ESCs_Mouse0.91157011
80AR_19668381_ChIP-Seq_PC3_Human0.90815345
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90804740
82TBX20_22328084_ChIP-Seq_HEART_Mouse0.90404482
83TBX20_22080862_ChIP-Seq_HEART_Mouse0.90404482
84CTCF_27219007_Chip-Seq_Bcells_Human0.89931042
85SMAD4_21799915_ChIP-Seq_A2780_Human0.89765858
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.87750846
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87502019
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86023976
89RXR_22108803_ChIP-Seq_LS180_Human0.85682829
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.84235932
91KDM2B_26808549_Chip-Seq_K562_Human0.84096033
92LXR_22292898_ChIP-Seq_THP-1_Human0.84071595
93DPY_21335234_ChIP-Seq_ESCs_Mouse0.82777871
94ZNF263_19887448_ChIP-Seq_K562_Human0.81734601
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81723347
96RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81446494
97* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81218126
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81137464
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81096174
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81062163
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81062163
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80603958
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80282901
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80049875
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79901242
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79895292
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.78945333
108EGR1_19032775_ChIP-ChIP_M12_Human0.78899307
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78867486
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.78634957
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78560822
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78232798
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77900919
114AR_25329375_ChIP-Seq_VCAP_Human0.77540771
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.77217023
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77211964
117* HNF4A_19822575_ChIP-Seq_HepG2_Human0.76915597
118CREB1_26743006_Chip-Seq_LNCaP_Human0.76085056
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76033395
120* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75967922
121KLF4_19829295_ChIP-Seq_ESCs_Human0.75646529
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75193657
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.74992631
124KDM2B_26808549_Chip-Seq_DND41_Human0.73273060
125SMAD4_21741376_ChIP-Seq_ESCs_Human0.72706480
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72610028
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72604855
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72116690
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71139553
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.71036954
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.69598077
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.68617895
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.67732169
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66898145
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.66547203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.20495507
2MP0005360_urolithiasis4.54360268
3MP0005085_abnormal_gallbladder_physiolo4.12910932
4MP0005365_abnormal_bile_salt3.89525149
5MP0008875_abnormal_xenobiotic_pharmacok3.20694351
6MP0004859_abnormal_synaptic_plasticity3.12722329
7MP0003646_muscle_fatigue2.64971769
8MP0010329_abnormal_lipoprotein_level2.64645272
9MP0002837_dystrophic_cardiac_calcinosis2.61861371
10MP0003806_abnormal_nucleotide_metabolis2.40308090
11MP0009840_abnormal_foam_cell2.38488800
12MP0003879_abnormal_hair_cell2.36995700
13MP0003252_abnormal_bile_duct2.34556714
14MP0002822_catalepsy2.30367592
15MP0000751_myopathy2.24501434
16MP0005332_abnormal_amino_acid2.19505187
17MP0004130_abnormal_muscle_cell2.10481637
18MP0005083_abnormal_biliary_tract2.04774442
19MP0000920_abnormal_myelination2.03254644
20MP0003329_amyloid_beta_deposits1.94041187
21MP0003635_abnormal_synaptic_transmissio1.92914096
22MP0003690_abnormal_glial_cell1.85074211
23MP0001970_abnormal_pain_threshold1.80983957
24MP0002735_abnormal_chemical_nociception1.76651670
25MP0004215_abnormal_myocardial_fiber1.73152600
26MP0003195_calcinosis1.71720493
27MP0002118_abnormal_lipid_homeostasis1.69260851
28MP0009745_abnormal_behavioral_response1.65184541
29MP0004270_analgesia1.63196584
30MP0004036_abnormal_muscle_relaxation1.56733615
31MP0002064_seizures1.56596379
32MP0009046_muscle_twitch1.54049684
33MP0002063_abnormal_learning/memory/cond1.47785055
34MP0000749_muscle_degeneration1.45581304
35MP0005584_abnormal_enzyme/coenzyme_acti1.43752406
36MP0002066_abnormal_motor_capabilities/c1.42610447
37MP0004858_abnormal_nervous_system1.41159937
38MP0002909_abnormal_adrenal_gland1.41138093
39MP0003880_abnormal_central_pattern1.40127681
40MP0001666_abnormal_nutrient_absorption1.39527212
41MP0001486_abnormal_startle_reflex1.37731964
42MP0002557_abnormal_social/conspecific_i1.36970037
43MP0004811_abnormal_neuron_physiology1.36523258
44MP0000604_amyloidosis1.35423120
45MP0005646_abnormal_pituitary_gland1.33377155
46MP0004145_abnormal_muscle_electrophysio1.32985759
47MP0009780_abnormal_chondrocyte_physiolo1.32845074
48MP0005330_cardiomyopathy1.31262517
49MP0004084_abnormal_cardiac_muscle1.30370781
50MP0003634_abnormal_glial_cell1.29949523
51MP0003137_abnormal_impulse_conducting1.26389461
52MP0003075_altered_response_to1.22290637
53MP0002572_abnormal_emotion/affect_behav1.21404079
54MP0008569_lethality_at_weaning1.21262252
55MP0002882_abnormal_neuron_morphology1.20727610
56MP0002272_abnormal_nervous_system1.20498882
57MP0002269_muscular_atrophy1.19802035
58MP0000747_muscle_weakness1.19607593
59MP0005423_abnormal_somatic_nervous1.19599790
60MP0000778_abnormal_nervous_system1.19136447
61MP0003191_abnormal_cellular_cholesterol1.18901518
62MP0005319_abnormal_enzyme/_coenzyme1.18882118
63MP0005535_abnormal_body_temperature1.17478282
64MP0000609_abnormal_liver_physiology1.17422021
65MP0003633_abnormal_nervous_system1.16560735
66MP0000955_abnormal_spinal_cord1.16549701
67MP0001177_atelectasis1.16169810
68MP0004087_abnormal_muscle_fiber1.15605222
69MP0005620_abnormal_muscle_contractility1.14602291
70MP0001905_abnormal_dopamine_level1.13872438
71MP0006036_abnormal_mitochondrial_physio1.12541168
72MP0005167_abnormal_blood-brain_barrier1.12148028
73MP0003632_abnormal_nervous_system1.11719575
74MP0004885_abnormal_endolymph1.10886328
75MP0001501_abnormal_sleep_pattern1.10407859
76MP0006276_abnormal_autonomic_nervous1.10255490
77MP0001968_abnormal_touch/_nociception1.08644072
78MP0001440_abnormal_grooming_behavior1.06777574
79MP0002972_abnormal_cardiac_muscle1.06640312
80MP0005670_abnormal_white_adipose1.05268592
81MP0004019_abnormal_vitamin_homeostasis1.03275314
82MP0002229_neurodegeneration1.02579732
83MP0002254_reproductive_system_inflammat1.01166145
84MP0004085_abnormal_heartbeat1.00926723
85MP0003868_abnormal_feces_composition1.00880376
86MP0001963_abnormal_hearing_physiology1.00096891
87MP0001485_abnormal_pinna_reflex0.99671351
88MP0003787_abnormal_imprinting0.98468169
89MP0004043_abnormal_pH_regulation0.97160423
90MP0008874_decreased_physiological_sensi0.96599329
91MP0002734_abnormal_mechanical_nocicepti0.93682574
92MP0003705_abnormal_hypodermis_morpholog0.92898664
93MP0002971_abnormal_brown_adipose0.91300599
94MP0004147_increased_porphyrin_level0.91244046
95MP0004742_abnormal_vestibular_system0.91194414
96MP0003631_nervous_system_phenotype0.89435445
97MP0004924_abnormal_behavior0.88247000
98MP0005386_behavior/neurological_phenoty0.88247000
99MP0002078_abnormal_glucose_homeostasis0.87905331
100MP0002638_abnormal_pupillary_reflex0.87437390
101MP0002067_abnormal_sensory_capabilities0.87062112
102MP0001502_abnormal_circadian_rhythm0.86875319
103MP0002152_abnormal_brain_morphology0.86649261
104MP0005166_decreased_susceptibility_to0.84476696
105MP0006138_congestive_heart_failure0.84456721
106MP0008775_abnormal_heart_ventricle0.84157367
107MP0003656_abnormal_erythrocyte_physiolo0.82701103
108MP0002090_abnormal_vision0.82545223
109MP0005666_abnormal_adipose_tissue0.82368305
110MP0005551_abnormal_eye_electrophysiolog0.82247852
111MP0002184_abnormal_innervation0.81481602
112MP0005385_cardiovascular_system_phenoty0.81116738
113MP0001544_abnormal_cardiovascular_syste0.81116738
114MP0003011_delayed_dark_adaptation0.80996368
115MP0004142_abnormal_muscle_tone0.80662291
116MP0002106_abnormal_muscle_physiology0.80505008
117MP0002733_abnormal_thermal_nociception0.79971772
118MP0002736_abnormal_nociception_after0.79728827
119MP0006035_abnormal_mitochondrial_morpho0.78610198
120MP0004484_altered_response_of0.78431406
121MP0008872_abnormal_physiological_respon0.78288512
122MP0001984_abnormal_olfaction0.77927237
123MP0001986_abnormal_taste_sensitivity0.77504359
124MP0000579_abnormal_nail_morphology0.77281469
125MP0008961_abnormal_basal_metabolism0.75664387
126MP0004510_myositis0.74033051
127MP0003123_paternal_imprinting0.71652125
128MP0002332_abnormal_exercise_endurance0.71633598
129MP0005647_abnormal_sex_gland0.70812644
130MP0000759_abnormal_skeletal_muscle0.70412188
131MP0005369_muscle_phenotype0.69508417
132MP0001346_abnormal_lacrimal_gland0.68147127
133MP0002069_abnormal_eating/drinking_beha0.65242202
134MP0001299_abnormal_eye_distance/0.59099266
135MP0003122_maternal_imprinting0.58665432
136MP0000566_synostosis0.57783208
137MP0002249_abnormal_larynx_morphology0.54076575
138MP0000026_abnormal_inner_ear0.52839489
139MP0005409_darkened_coat_color0.52424271

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.76398018
2Diplopia (HP:0000651)4.61870874
3Abnormality of binocular vision (HP:0011514)4.61870874
4Xanthomatosis (HP:0000991)4.45821553
5Intrahepatic cholestasis (HP:0001406)4.41789694
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.39324770
7Ankle clonus (HP:0011448)4.37796600
8Febrile seizures (HP:0002373)4.36465650
9Hyperlipoproteinemia (HP:0010980)4.32617412
10Atonic seizures (HP:0010819)4.13499985
11Exercise-induced myalgia (HP:0003738)4.01579560
12Hyperammonemia (HP:0001987)3.95761872
13Ketosis (HP:0001946)3.93246026
14Supranuclear gaze palsy (HP:0000605)3.86370267
15Epileptic encephalopathy (HP:0200134)3.83357232
16Muscle fiber inclusion bodies (HP:0100299)3.71579599
17Obstructive sleep apnea (HP:0002870)3.70557545
18Hypoalphalipoproteinemia (HP:0003233)3.63669435
19Hypobetalipoproteinemia (HP:0003563)3.63425006
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62516325
21Hyperglycinemia (HP:0002154)3.62187245
22Prolonged partial thromboplastin time (HP:0003645)3.57848239
23Hyperglycinuria (HP:0003108)3.56895825
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.54589392
25Ketoacidosis (HP:0001993)3.53315953
26Abnormality of glycine metabolism (HP:0010895)3.52791404
27Abnormality of serine family amino acid metabolism (HP:0010894)3.52791404
28Hypoglycemic coma (HP:0001325)3.52344134
29Nemaline bodies (HP:0003798)3.49647120
30Hypolipoproteinemia (HP:0010981)3.40442939
31Myoglobinuria (HP:0002913)3.36613474
32Complement deficiency (HP:0004431)3.29170866
33Abnormal eating behavior (HP:0100738)3.27299878
34Myokymia (HP:0002411)3.25770261
35Muscle fiber splitting (HP:0003555)3.22311475
36Spastic gait (HP:0002064)3.16727210
37Exercise-induced muscle cramps (HP:0003710)3.13945544
38Cerebral inclusion bodies (HP:0100314)3.11780996
39Absence seizures (HP:0002121)3.09218634
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.03937955
41Focal motor seizures (HP:0011153)3.01093333
42Epidermoid cyst (HP:0200040)2.99409754
43Sudden death (HP:0001699)2.97174227
44Peripheral hypomyelination (HP:0007182)2.91106403
45Dysmetria (HP:0001310)2.89014284
46Progressive cerebellar ataxia (HP:0002073)2.87336331
47Truncal ataxia (HP:0002078)2.85128318
48Cerebral hypomyelination (HP:0006808)2.84313657
49Dialeptic seizures (HP:0011146)2.81167054
50Status epilepticus (HP:0002133)2.79496904
51Papilledema (HP:0001085)2.79109285
52Abnormality of fatty-acid metabolism (HP:0004359)2.76885984
53Urinary bladder sphincter dysfunction (HP:0002839)2.76767832
54Type 1 muscle fiber predominance (HP:0003803)2.76604166
55Annular pancreas (HP:0001734)2.74545174
56EMG: myopathic abnormalities (HP:0003458)2.73934570
57Mutism (HP:0002300)2.71754268
58Increased circulating renin level (HP:0000848)2.69733710
59Delayed CNS myelination (HP:0002188)2.65938337
60Hemiparesis (HP:0001269)2.65260361
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58634033
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.58618026
63Atrioventricular block (HP:0001678)2.56849217
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56590215
65Limb dystonia (HP:0002451)2.54912368
66Bundle branch block (HP:0011710)2.54500259
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54267145
68Abnormality of methionine metabolism (HP:0010901)2.54027349
69Akinesia (HP:0002304)2.52376970
70Urinary urgency (HP:0000012)2.50855042
71Heart block (HP:0012722)2.50186632
72Calf muscle hypertrophy (HP:0008981)2.50020964
73Cholelithiasis (HP:0001081)2.47541535
74Gout (HP:0001997)2.45585250
75Poor eye contact (HP:0000817)2.44644755
76Foot dorsiflexor weakness (HP:0009027)2.44039509
77Action tremor (HP:0002345)2.43348239
78Rigidity (HP:0002063)2.42752873
79Hypercholesterolemia (HP:0003124)2.42364126
80Lower limb muscle weakness (HP:0007340)2.42071636
81Muscle hypertrophy of the lower extremities (HP:0008968)2.38717689
82Abnormal gallbladder morphology (HP:0012437)2.38293663
83Fetal akinesia sequence (HP:0001989)2.37933204
84Abnormality of the foot musculature (HP:0001436)2.37551533
85Myopathic facies (HP:0002058)2.37248406
86Sleep apnea (HP:0010535)2.37137311
87Scanning speech (HP:0002168)2.35082065
88Abnormality of the common coagulation pathway (HP:0010990)2.34296306
89Clonus (HP:0002169)2.34186407
90Joint hemorrhage (HP:0005261)2.33155904
91Skin nodule (HP:0200036)2.32263092
92Rapidly progressive (HP:0003678)2.29259540
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28567988
94Dicarboxylic aciduria (HP:0003215)2.28567988
95Metabolic acidosis (HP:0001942)2.28497499
96Delusions (HP:0000746)2.28328701
97Impaired vibration sensation in the lower limbs (HP:0002166)2.27253395
98Abnormal atrioventricular conduction (HP:0005150)2.26703810
99Hyperinsulinemic hypoglycemia (HP:0000825)2.26117139
100Neuronal loss in central nervous system (HP:0002529)2.25880436
101Abnormality of serum amino acid levels (HP:0003112)2.25583968
102Hyperbilirubinemia (HP:0002904)2.25187058
103Sensorimotor neuropathy (HP:0007141)2.24932773
104Ventricular fibrillation (HP:0001663)2.23986442
105Dysdiadochokinesis (HP:0002075)2.23430501
106Bradykinesia (HP:0002067)2.22475854
107Hyporeflexia of lower limbs (HP:0002600)2.20957458
108Neonatal onset (HP:0003623)2.20817701
109Frequent falls (HP:0002359)2.20732098
110Postural instability (HP:0002172)2.20614349
111Centrally nucleated skeletal muscle fibers (HP:0003687)2.19918231
112Focal dystonia (HP:0004373)2.19445665
113Hypoglycemic seizures (HP:0002173)2.18191357
114EMG: neuropathic changes (HP:0003445)2.16827507
115Lower limb amyotrophy (HP:0007210)2.15606691
116Generalized tonic-clonic seizures (HP:0002069)2.13378221
117Syncope (HP:0001279)2.12812875
118Ventricular arrhythmia (HP:0004308)2.12787182
119Fat malabsorption (HP:0002630)2.12041706
120Neurofibrillary tangles (HP:0002185)2.11931300
121Dysmetric saccades (HP:0000641)2.11153357
122Focal seizures (HP:0007359)2.10952283
123Abnormality of complement system (HP:0005339)2.09843704
124Atrial fibrillation (HP:0005110)2.08691608
125Megalencephaly (HP:0001355)2.07456796
126Cholecystitis (HP:0001082)2.06802336
127Abnormal gallbladder physiology (HP:0012438)2.06802336
128Hemiplegia (HP:0002301)2.06579806
129Hyperventilation (HP:0002883)2.06292312
130Late onset (HP:0003584)2.06178367
131Pheochromocytoma (HP:0002666)2.05146731
132Craniofacial dystonia (HP:0012179)2.04674381
133Cerebral edema (HP:0002181)2.04372132
134Lethargy (HP:0001254)2.03644361
135Anxiety (HP:0000739)2.02933495
136Muscle stiffness (HP:0003552)2.02749273
137Visual hallucinations (HP:0002367)2.02385973
138Subaortic stenosis (HP:0001682)2.01613898
139Abnormality of the left ventricular outflow tract (HP:0011103)2.01613898
140Abnormality of the calf musculature (HP:0001430)2.01382094
141Aplasia involving bones of the upper limbs (HP:0009823)2.00592519
142Aplasia of the phalanges of the hand (HP:0009802)2.00592519
143Aplasia involving bones of the extremities (HP:0009825)2.00592519
144Difficulty running (HP:0009046)1.99993213
145Tetraplegia (HP:0002445)1.98523860
146Split foot (HP:0001839)1.97202114
147Abnormality of the Achilles tendon (HP:0005109)1.97150339
148Spastic tetraparesis (HP:0001285)1.96926123
149Rhabdomyolysis (HP:0003201)1.96280835
150Abnormality of the corticospinal tract (HP:0002492)1.96201209
151Impaired social interactions (HP:0000735)1.95468748
152Abnormal social behavior (HP:0012433)1.95468748
153Primary atrial arrhythmia (HP:0001692)1.95156016
154Insomnia (HP:0100785)1.94745737
155Epileptiform EEG discharges (HP:0011182)1.94424202
156Prolonged QT interval (HP:0001657)1.93838243
157Asymmetric septal hypertrophy (HP:0001670)1.93608460
158Torticollis (HP:0000473)1.93511043
159Amyloidosis (HP:0011034)1.93161254
160Myotonia (HP:0002486)1.92816306
161Abnormality of the intrinsic pathway (HP:0010989)1.92533038
162Intention tremor (HP:0002080)1.87860230
163Depression (HP:0000716)1.86107295
164Conjugated hyperbilirubinemia (HP:0002908)1.83741775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.51511167
2LMTK23.50027178
3PHKG13.30365026
4PHKG23.30365026
5BCKDK2.98138797
6TRIB32.76389918
7UHMK12.67942734
8PINK12.58076087
9NTRK32.33446205
10MAP2K42.32205370
11SIK12.28740896
12NTRK22.14164418
13PRKD32.09362400
14DAPK21.94940601
15MAP3K41.94499350
16MAP3K91.93614113
17OBSCN1.83955833
18STK381.59878312
19PDK31.59664870
20PDK41.59664870
21CAMKK11.58843830
22PKN21.57497716
23TTN1.56751265
24NEK11.53745574
25PAK61.53448254
26KSR21.52585560
27MINK11.45565290
28MAP3K71.42101131
29CASK1.35584524
30MAP2K71.29714317
31RIPK11.25632377
32MAPK131.22901411
33PKN11.20581721
34PLK21.19718920
35NTRK11.19304190
36MARK11.15637482
37NEK61.11475906
38MUSK1.10507557
39MARK21.09445414
40INSRR1.09343460
41DMPK1.07962747
42FGFR41.06631198
43PAK31.04001131
44MAPK121.01968492
45PRKCH1.00709098
46RIPK40.97281319
47PRKCG0.93966314
48CDK50.91850326
49TNIK0.90410256
50DAPK10.90360029
51CAMK2G0.90214154
52PDPK10.86306289
53RET0.85937223
54MAPK100.85912955
55CDK150.84563151
56DYRK1A0.83282148
57TYRO30.82468099
58CAMK10.80893322
59FGFR20.80657328
60CDK180.79284440
61MAP3K130.78003176
62CAMK2A0.77624030
63ROCK20.77365431
64PDK10.76569946
65CAMK40.76330460
66PRKAA10.76171241
67CDK11A0.76090153
68PIK3CA0.75255508
69PDK20.74887989
70ERN10.74851306
71PRKAA20.73228369
72CDK140.73118632
73CDK190.70239383
74TAOK10.70124162
75CAMK1G0.69623702
76PRKD10.69029866
77LATS20.67720617
78PRKACG0.66508894
79ALK0.65267758
80SIK20.63414225
81LIMK10.62886039
82PTK60.62884433
83* SGK4940.62776833
84* SGK2230.62776833
85ERBB40.62394604
86STK110.62126815
87GRK50.61849700
88CAMK2D0.61839268
89KSR10.60236704
90FES0.60160710
91CDC42BPA0.59776623
92MAPK110.59108081
93MAP3K20.59083521
94MAP3K10.58758925
95ROCK10.58477976
96PRPF4B0.57986420
97PDGFRA0.57370145
98PRKCZ0.57057626
99RPS6KA30.56462469
100MYLK0.55980614
101CAMKK20.55750951
102CAMK1D0.52920068
103DAPK30.51887969
104PIK3CG0.49997756
105JAK20.49276841
106WNK10.48930498
107MAPK40.48520301
108PRKG10.47393409
109ARAF0.46413068
110MAP2K60.45575628
111OXSR10.44094105
112MAPKAPK50.43805072
113MAP2K10.43651037
114PTK2B0.43074572
115PRKACA0.42842661
116* SGK10.41537236
117RAF10.40904017
118* SGK30.40896568
119MAP3K110.40570401
120TIE10.40215148
121PRKACB0.40169337
122PRKG20.39667336
123BMX0.39628619
124ERBB20.39408968
125ICK0.38996358
126FYN0.38864386
127TAOK20.38098677
128TNK20.37959835
129JAK10.37514289
130BRSK10.37514048
131CAMK2B0.37226560
132BRAF0.36417321
133MAPK70.36099004
134PRKCA0.35413705
135CCNB10.32918729

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.40890383
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24529164
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.10945151
4Arginine biosynthesis_Homo sapiens_hsa002202.91197446
5Fatty acid degradation_Homo sapiens_hsa000712.55996617
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44063984
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27106441
8Butanoate metabolism_Homo sapiens_hsa006502.24213619
9Propanoate metabolism_Homo sapiens_hsa006402.23904649
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22300679
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18465328
12Fatty acid metabolism_Homo sapiens_hsa012122.12864089
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99637623
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98160323
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.96362518
16Tryptophan metabolism_Homo sapiens_hsa003801.92366848
17PPAR signaling pathway_Homo sapiens_hsa033201.78978525
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69732531
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67189268
20Bile secretion_Homo sapiens_hsa049761.66821563
21Complement and coagulation cascades_Homo sapiens_hsa046101.56897218
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55959547
23Peroxisome_Homo sapiens_hsa041461.48658697
24Fatty acid biosynthesis_Homo sapiens_hsa000611.41378150
25beta-Alanine metabolism_Homo sapiens_hsa004101.36639788
26Carbon metabolism_Homo sapiens_hsa012001.36276485
27Pyruvate metabolism_Homo sapiens_hsa006201.32462287
28GnRH signaling pathway_Homo sapiens_hsa049121.23309184
29Biosynthesis of amino acids_Homo sapiens_hsa012301.22650595
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16649323
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16326462
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14969810
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13800153
34Starch and sucrose metabolism_Homo sapiens_hsa005001.13656046
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11451642
36Long-term depression_Homo sapiens_hsa047301.11382036
37Estrogen signaling pathway_Homo sapiens_hsa049151.08742539
38Fatty acid elongation_Homo sapiens_hsa000621.08647778
39Pancreatic secretion_Homo sapiens_hsa049721.05625211
40Phenylalanine metabolism_Homo sapiens_hsa003601.05150340
41Chemical carcinogenesis_Homo sapiens_hsa052041.03941596
42GABAergic synapse_Homo sapiens_hsa047271.03708132
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99468885
44Caffeine metabolism_Homo sapiens_hsa002320.98976506
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.96809094
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95773974
47Serotonergic synapse_Homo sapiens_hsa047260.93732518
48Nicotine addiction_Homo sapiens_hsa050330.93004964
49Glioma_Homo sapiens_hsa052140.92959465
50Histidine metabolism_Homo sapiens_hsa003400.92523700
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.91432387
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.89367489
53Gap junction_Homo sapiens_hsa045400.87687261
54Melanogenesis_Homo sapiens_hsa049160.87374493
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.87275843
56Thyroid hormone synthesis_Homo sapiens_hsa049180.85973253
57Sulfur metabolism_Homo sapiens_hsa009200.85385379
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84346880
59Tyrosine metabolism_Homo sapiens_hsa003500.84245538
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84221934
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83015198
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82441372
63Cardiac muscle contraction_Homo sapiens_hsa042600.81673714
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76292607
65Retinol metabolism_Homo sapiens_hsa008300.76003818
66Glutamatergic synapse_Homo sapiens_hsa047240.75965588
67Arginine and proline metabolism_Homo sapiens_hsa003300.75678555
68ABC transporters_Homo sapiens_hsa020100.74765040
69Circadian entrainment_Homo sapiens_hsa047130.72768236
70Collecting duct acid secretion_Homo sapiens_hsa049660.71524601
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70832421
72Insulin secretion_Homo sapiens_hsa049110.69362948
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68200522
74Staphylococcus aureus infection_Homo sapiens_hsa051500.68179594
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67703395
76ErbB signaling pathway_Homo sapiens_hsa040120.66848941
77Salivary secretion_Homo sapiens_hsa049700.65257252
78Fat digestion and absorption_Homo sapiens_hsa049750.64688464
79Glycerolipid metabolism_Homo sapiens_hsa005610.64447636
80Glucagon signaling pathway_Homo sapiens_hsa049220.63744645
81Synaptic vesicle cycle_Homo sapiens_hsa047210.63740617
82Gastric acid secretion_Homo sapiens_hsa049710.63735012
83Olfactory transduction_Homo sapiens_hsa047400.63234810
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63137767
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.61489309
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61351433
87Dilated cardiomyopathy_Homo sapiens_hsa054140.60381819
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.58854832
89Morphine addiction_Homo sapiens_hsa050320.58403557
90VEGF signaling pathway_Homo sapiens_hsa043700.58275764
91Mineral absorption_Homo sapiens_hsa049780.57058000
92Lysine degradation_Homo sapiens_hsa003100.56693887
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.55914680
94Inositol phosphate metabolism_Homo sapiens_hsa005620.55705583
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54891369
96Oocyte meiosis_Homo sapiens_hsa041140.54146038
97MAPK signaling pathway_Homo sapiens_hsa040100.54038341
98Selenocompound metabolism_Homo sapiens_hsa004500.52739192
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52633360
100AMPK signaling pathway_Homo sapiens_hsa041520.51965871
101Insulin resistance_Homo sapiens_hsa049310.51086679
102Vitamin B6 metabolism_Homo sapiens_hsa007500.49800172
103Calcium signaling pathway_Homo sapiens_hsa040200.49606929
104Rap1 signaling pathway_Homo sapiens_hsa040150.49222705
105Choline metabolism in cancer_Homo sapiens_hsa052310.48726351
106Long-term potentiation_Homo sapiens_hsa047200.48597664
107Amphetamine addiction_Homo sapiens_hsa050310.46440282
108Ras signaling pathway_Homo sapiens_hsa040140.46116101
109Axon guidance_Homo sapiens_hsa043600.45259624
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44204969
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43863190
112Vibrio cholerae infection_Homo sapiens_hsa051100.43500204
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43418381
114Renin secretion_Homo sapiens_hsa049240.42159714
115Type II diabetes mellitus_Homo sapiens_hsa049300.41637163
116Dorso-ventral axis formation_Homo sapiens_hsa043200.41481618
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.39603383
118Endocytosis_Homo sapiens_hsa041440.39553502
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38995643
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38876516
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.38295032
122Insulin signaling pathway_Homo sapiens_hsa049100.36899781
123Fructose and mannose metabolism_Homo sapiens_hsa000510.36848255
124Ovarian steroidogenesis_Homo sapiens_hsa049130.36758504
125Tight junction_Homo sapiens_hsa045300.36515069
126Sulfur relay system_Homo sapiens_hsa041220.36427478
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36382421
128cAMP signaling pathway_Homo sapiens_hsa040240.35921855
129Prion diseases_Homo sapiens_hsa050200.35633438
130Oxytocin signaling pathway_Homo sapiens_hsa049210.35021380
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34840380
132Cholinergic synapse_Homo sapiens_hsa047250.34589832
133Steroid biosynthesis_Homo sapiens_hsa001000.33874857
134Dopaminergic synapse_Homo sapiens_hsa047280.33224271
135Cocaine addiction_Homo sapiens_hsa050300.32705482
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32686261
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.32593838
138Circadian rhythm_Homo sapiens_hsa047100.31369834
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31207760
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30624694
141Taste transduction_Homo sapiens_hsa047420.30139259
142Phototransduction_Homo sapiens_hsa047440.28613070
143Pentose phosphate pathway_Homo sapiens_hsa000300.27263731
144mTOR signaling pathway_Homo sapiens_hsa041500.25674234

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