NDP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.23475754
2central nervous system myelination (GO:0022010)6.23475754
3L-amino acid import (GO:0043092)4.50782656
4locomotory exploration behavior (GO:0035641)4.40365155
5presynaptic membrane assembly (GO:0097105)4.29139719
6presynaptic membrane organization (GO:0097090)4.12483179
7neuron cell-cell adhesion (GO:0007158)4.03714193
8cerebral cortex radially oriented cell migration (GO:0021799)3.97801103
9amino acid import (GO:0043090)3.82091142
10regulation of sarcomere organization (GO:0060297)3.80065347
11lateral sprouting from an epithelium (GO:0060601)3.78715143
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.73280147
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70521367
14cerebellar granule cell differentiation (GO:0021707)3.69085653
15regulation of female gonad development (GO:2000194)3.67333277
16neurotransmitter uptake (GO:0001504)3.53989788
17sensory perception of smell (GO:0007608)3.47448007
18exploration behavior (GO:0035640)3.47316797
19negative regulation of neurotransmitter transport (GO:0051589)3.46505672
20neuronal action potential propagation (GO:0019227)3.44235795
21limb bud formation (GO:0060174)3.40230923
22membrane depolarization during action potential (GO:0086010)3.38942252
23regulation of synaptic vesicle exocytosis (GO:2000300)3.38847924
24negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38409014
25neuron remodeling (GO:0016322)3.36314056
26positive regulation of synapse maturation (GO:0090129)3.35687125
27negative regulation of astrocyte differentiation (GO:0048712)3.35451428
28synaptic vesicle maturation (GO:0016188)3.32558957
29neuronal ion channel clustering (GO:0045161)3.31237759
30long-chain fatty acid biosynthetic process (GO:0042759)3.30978004
31postsynaptic membrane organization (GO:0001941)3.23304695
32vocalization behavior (GO:0071625)3.23098788
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21662517
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18846192
35positive regulation of dendritic spine development (GO:0060999)3.15472092
36endothelial cell chemotaxis (GO:0035767)3.14433900
37response to misfolded protein (GO:0051788)3.13582644
38protein localization to synapse (GO:0035418)3.12913160
39response to auditory stimulus (GO:0010996)3.11316412
40sodium ion export (GO:0071436)3.08358677
41myelination (GO:0042552)3.06864032
42neuron recognition (GO:0008038)3.05933085
43negative regulation of protein localization to cell surface (GO:2000009)3.05747289
44fatty acid elongation (GO:0030497)3.04498336
45regulation of neurotransmitter uptake (GO:0051580)3.02365931
46regulation of timing of cell differentiation (GO:0048505)3.02282198
47positive regulation of action potential (GO:0045760)2.99661740
48neuromuscular synaptic transmission (GO:0007274)2.98997938
49L-glutamate transport (GO:0015813)2.98823712
50positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.98184127
51regulation of synapse structural plasticity (GO:0051823)2.98101914
52eye photoreceptor cell differentiation (GO:0001754)2.97506039
53photoreceptor cell differentiation (GO:0046530)2.97506039
54ensheathment of neurons (GO:0007272)2.95894416
55axon ensheathment (GO:0008366)2.95894416
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.95633947
57proline transport (GO:0015824)2.95505731
58glutamate receptor signaling pathway (GO:0007215)2.94623686
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94427353
60regulation of voltage-gated calcium channel activity (GO:1901385)2.92198810
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91088760
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90735527
63righting reflex (GO:0060013)2.90095597
64oligodendrocyte differentiation (GO:0048709)2.89749106
65potassium ion import (GO:0010107)2.88007952
66negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87912431
67negative regulation of adenylate cyclase activity (GO:0007194)2.86973436
68regulation of synaptic vesicle transport (GO:1902803)2.86616186
69central nervous system neuron axonogenesis (GO:0021955)2.86088161
70neurotransmitter secretion (GO:0007269)2.84737318
71positive regulation of synapse assembly (GO:0051965)2.84184033
72regulation of neurotransmitter transport (GO:0051588)2.83673675
73lipopolysaccharide biosynthetic process (GO:0009103)2.83323649
74regulation of synapse maturation (GO:0090128)2.80148400
75membrane depolarization (GO:0051899)2.78517251
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78499740
77transmission of nerve impulse (GO:0019226)2.77538368
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75647728
79cellular potassium ion homeostasis (GO:0030007)2.74850508
80positive regulation of neurotransmitter secretion (GO:0001956)2.73276292
81auditory behavior (GO:0031223)2.73128612
82import into cell (GO:0098657)2.73001924
83regulation of neurotransmitter secretion (GO:0046928)2.72982773
84gamma-aminobutyric acid transport (GO:0015812)2.72492997
85cellular response to sterol (GO:0036315)2.72258147
86retina layer formation (GO:0010842)2.72178758
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.72029486
88regulation of translation, ncRNA-mediated (GO:0045974)2.72029486
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72029486
90negative regulation of cAMP biosynthetic process (GO:0030818)2.71974144
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71274317
92regulation of respiratory system process (GO:0044065)2.70828100
93negative regulation of cyclase activity (GO:0031280)2.67904989
94cell proliferation in forebrain (GO:0021846)2.67767981
95regulation of dendritic spine development (GO:0060998)2.67718431
96positive regulation of cellular amide metabolic process (GO:0034250)2.67235725
97detection of temperature stimulus (GO:0016048)2.67065362
98dendritic spine morphogenesis (GO:0060997)2.65515144
99mechanosensory behavior (GO:0007638)2.65464331
100regulation of gonadotropin secretion (GO:0032276)2.65433663
101axonal fasciculation (GO:0007413)2.65059192
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.64462146
103negative regulation of neurotransmitter secretion (GO:0046929)2.63733348
104regulation of cardiac muscle cell contraction (GO:0086004)2.62958086
105regulation of astrocyte differentiation (GO:0048710)2.62879401
106synaptic transmission, glutamatergic (GO:0035249)2.62290780
107protein localization to cilium (GO:0061512)2.60377714
108detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.60168204
109detection of temperature stimulus involved in sensory perception (GO:0050961)2.60168204
110negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.59739842
111potassium ion transmembrane transport (GO:0071805)2.59091072
112cellular potassium ion transport (GO:0071804)2.59091072
113long-term memory (GO:0007616)2.58694269
114positive regulation of male gonad development (GO:2000020)2.58575484
115negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.58141536
116cerebral cortex cell migration (GO:0021795)2.57651054
117neurotransmitter-gated ion channel clustering (GO:0072578)2.56799725
118synapse assembly (GO:0007416)2.55568659
119neuron-neuron synaptic transmission (GO:0007270)2.53838849
120regulation of synaptic transmission, glutamatergic (GO:0051966)2.53774153
121regulation of respiratory gaseous exchange (GO:0043576)2.53759263
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53640697
123cranial nerve development (GO:0021545)2.52915751
124long-term synaptic potentiation (GO:0060291)2.51331481
125regulation of platelet aggregation (GO:0090330)2.46975234
126chondroitin sulfate catabolic process (GO:0030207)2.46114812
127adult walking behavior (GO:0007628)2.45596055
128synaptic vesicle exocytosis (GO:0016079)2.45289092
129regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45132333
130regulation of development, heterochronic (GO:0040034)2.44968205
131central nervous system projection neuron axonogenesis (GO:0021952)2.44630654
132glutamate secretion (GO:0014047)2.43543399
133regulation of beta-amyloid formation (GO:1902003)2.43270135
134regulation of glutamate receptor signaling pathway (GO:1900449)2.43172615
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43051252
136regulation of inositol phosphate biosynthetic process (GO:0010919)2.37597515
137spinal cord motor neuron differentiation (GO:0021522)2.37573325
138peripheral nervous system axon ensheathment (GO:0032292)2.35022451
139myelination in peripheral nervous system (GO:0022011)2.35022451
140C4-dicarboxylate transport (GO:0015740)2.34585269
141sympathetic nervous system development (GO:0048485)2.33368927
142positive regulation of alcohol biosynthetic process (GO:1902932)2.31914793
143potassium ion homeostasis (GO:0055075)2.30981122
144acidic amino acid transport (GO:0015800)2.30938816
145peripheral nervous system neuron development (GO:0048935)2.29970721
146regulation of collateral sprouting (GO:0048670)2.29274447
147membrane assembly (GO:0071709)2.28829328
148cranial nerve morphogenesis (GO:0021602)2.25974284
149regulation of synapse assembly (GO:0051963)2.25690080
150startle response (GO:0001964)2.25313111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64302234
2GBX2_23144817_ChIP-Seq_PC3_Human3.54497493
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91268389
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86927738
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80812345
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.66394667
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60735635
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.59382626
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50493533
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50493533
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50097238
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46215291
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39554543
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38401834
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19286613
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12131980
17TAF15_26573619_Chip-Seq_HEK293_Human2.11442691
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.10538890
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.09905716
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06897942
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02300110
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.01759486
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00914323
24AR_21572438_ChIP-Seq_LNCaP_Human1.98053760
25VDR_22108803_ChIP-Seq_LS180_Human1.92272413
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91484980
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89205212
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83520013
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81280132
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78887267
31P300_19829295_ChIP-Seq_ESCs_Human1.75435688
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72943788
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72705014
34REST_21632747_ChIP-Seq_MESCs_Mouse1.67984014
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64582406
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62596604
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61451550
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.60363892
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59856228
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58118621
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55682464
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.55007070
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.53632065
44DROSHA_22980978_ChIP-Seq_HELA_Human1.53304178
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51227440
46IGF1R_20145208_ChIP-Seq_DFB_Human1.49894954
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48139417
48RNF2_27304074_Chip-Seq_NSC_Mouse1.46902560
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37955526
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37010382
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35138742
52ER_23166858_ChIP-Seq_MCF-7_Human1.34643022
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31511763
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.31294312
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28270313
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26302254
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.25215493
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24598362
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24539613
60FUS_26573619_Chip-Seq_HEK293_Human1.23434238
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.22754020
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22534650
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21924775
64AR_25329375_ChIP-Seq_VCAP_Human1.20269809
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.18343291
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17826284
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17826284
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17581807
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17572260
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17294491
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.16861247
72AR_19668381_ChIP-Seq_PC3_Human1.16606789
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16323594
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16179819
75BCAT_22108803_ChIP-Seq_LS180_Human1.15657601
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15591713
77TP53_18474530_ChIP-ChIP_U2OS_Human1.15341112
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.13119097
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.11912265
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.11587607
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10525186
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.09484785
83STAT3_23295773_ChIP-Seq_U87_Human1.09320478
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09191875
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09089479
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.08915832
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07936857
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07681104
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.07497462
90RUNX2_22187159_ChIP-Seq_PCA_Human1.07039144
91P53_22387025_ChIP-Seq_ESCs_Mouse1.06583332
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.06357272
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05231163
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04762449
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04440549
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.04301529
97AHR_22903824_ChIP-Seq_MCF-7_Human1.03936754
98ZNF274_21170338_ChIP-Seq_K562_Hela1.03918907
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03386991
100RXR_22108803_ChIP-Seq_LS180_Human1.03308801
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03284841
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02949602
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00675098
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00422987
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00406576
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.00396002
107TCF4_23295773_ChIP-Seq_U87_Human1.00086913
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99361290
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98863901
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98205844
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.97601086
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97367309
113P300_18555785_Chip-Seq_ESCs_Mouse0.96688817
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.96667311
115* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96248762
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.95864590
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95524941
118SOX2_21211035_ChIP-Seq_LN229_Gbm0.94306480
119TP53_16413492_ChIP-PET_HCT116_Human0.94295825
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.94165379
121KDM2B_26808549_Chip-Seq_REH_Human0.94063888
122SOX2_18555785_Chip-Seq_ESCs_Mouse0.93380127
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91907526
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.89814974
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89062103
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88021447
127CBP_20019798_ChIP-Seq_JUKART_Human0.88021447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.67031196
2MP0001486_abnormal_startle_reflex2.76797047
3MP0005423_abnormal_somatic_nervous2.75593223
4MP0001984_abnormal_olfaction2.73750601
5MP0003136_yellow_coat_color2.73572291
6MP0004270_analgesia2.57150502
7MP0004859_abnormal_synaptic_plasticity2.48651123
8MP0009046_muscle_twitch2.45776011
9MP0003635_abnormal_synaptic_transmissio2.37721756
10MP0005646_abnormal_pituitary_gland2.37177992
11MP0009745_abnormal_behavioral_response2.33602559
12MP0005171_absent_coat_pigmentation2.31887982
13MP0001968_abnormal_touch/_nociception2.31494849
14MP0002064_seizures2.30079238
15MP0002735_abnormal_chemical_nociception2.29247060
16MP0002272_abnormal_nervous_system2.26177214
17MP0002572_abnormal_emotion/affect_behav2.14846259
18MP0002102_abnormal_ear_morphology2.13467220
19MP0004858_abnormal_nervous_system2.09763637
20MP0006292_abnormal_olfactory_placode2.06121161
21MP0000778_abnormal_nervous_system2.03860621
22MP0005645_abnormal_hypothalamus_physiol2.02943554
23MP0001485_abnormal_pinna_reflex2.00408627
24MP0006276_abnormal_autonomic_nervous2.00285914
25MP0002734_abnormal_mechanical_nocicepti1.99556259
26MP0002736_abnormal_nociception_after1.98558297
27MP0005167_abnormal_blood-brain_barrier1.97899039
28MP0002063_abnormal_learning/memory/cond1.97622106
29MP0001905_abnormal_dopamine_level1.95298335
30MP0003690_abnormal_glial_cell1.88078071
31MP0001440_abnormal_grooming_behavior1.85917973
32MP0000566_synostosis1.85510348
33MP0000920_abnormal_myelination1.85384060
34MP0004742_abnormal_vestibular_system1.83595359
35MP0005377_hearing/vestibular/ear_phenot1.81035006
36MP0003878_abnormal_ear_physiology1.81035006
37MP0003283_abnormal_digestive_organ1.80295239
38MP0004885_abnormal_endolymph1.79711463
39MP0002067_abnormal_sensory_capabilities1.79147297
40MP0002638_abnormal_pupillary_reflex1.74230273
41MP0001188_hyperpigmentation1.74080865
42MP0004142_abnormal_muscle_tone1.69747575
43MP0002733_abnormal_thermal_nociception1.66983079
44MP0001970_abnormal_pain_threshold1.65225715
45MP0002184_abnormal_innervation1.62807721
46MP0001529_abnormal_vocalization1.62492164
47MP0002557_abnormal_social/conspecific_i1.55798456
48MP0003938_abnormal_ear_development1.54889426
49MP0001501_abnormal_sleep_pattern1.53091772
50MP0003634_abnormal_glial_cell1.50145404
51MP0001502_abnormal_circadian_rhythm1.47957809
52MP0003329_amyloid_beta_deposits1.44220979
53MP0005551_abnormal_eye_electrophysiolog1.40683353
54MP0005409_darkened_coat_color1.40342548
55* MP0000026_abnormal_inner_ear1.36481570
56* MP0002882_abnormal_neuron_morphology1.34176395
57MP0008569_lethality_at_weaning1.33341229
58* MP0001963_abnormal_hearing_physiology1.31673286
59MP0002653_abnormal_ependyma_morphology1.27855226
60MP0003879_abnormal_hair_cell1.24655702
61MP0000955_abnormal_spinal_cord1.23885608
62* MP0002752_abnormal_somatic_nervous1.23876082
63MP0010368_abnormal_lymphatic_system1.21663230
64MP0003633_abnormal_nervous_system1.19788989
65MP0003631_nervous_system_phenotype1.17557109
66MP0002822_catalepsy1.16553033
67MP0000631_abnormal_neuroendocrine_gland1.13903084
68MP0004233_abnormal_muscle_weight1.11346091
69MP0004924_abnormal_behavior1.10088979
70MP0005386_behavior/neurological_phenoty1.10088979
71MP0000049_abnormal_middle_ear1.05647301
72MP0009250_abnormal_appendicular_skeleto1.04917482
73MP0003011_delayed_dark_adaptation1.04743587
74MP0002066_abnormal_motor_capabilities/c1.04289069
75MP0001986_abnormal_taste_sensitivity1.02006431
76MP0008260_abnormal_autophagy1.01615365
77* MP0002229_neurodegeneration1.00649129
78MP0004381_abnormal_hair_follicle1.00178061
79MP0003632_abnormal_nervous_system0.99234584
80MP0009053_abnormal_anal_canal0.95931278
81MP0003195_calcinosis0.95091189
82MP0002938_white_spotting0.94381042
83* MP0002152_abnormal_brain_morphology0.94053960
84MP0010386_abnormal_urinary_bladder0.90845189
85MP0004134_abnormal_chest_morphology0.89210413
86MP0002249_abnormal_larynx_morphology0.87855097
87MP0005394_taste/olfaction_phenotype0.87551734
88MP0005499_abnormal_olfactory_system0.87551734
89MP0000462_abnormal_digestive_system0.87391623
90MP0005253_abnormal_eye_physiology0.87234234
91MP0008789_abnormal_olfactory_epithelium0.83652753
92MP0004510_myositis0.81106831
93MP0001177_atelectasis0.79525567
94MP0000639_abnormal_adrenal_gland0.79215465
95MP0005410_abnormal_fertilization0.79121449
96MP0005670_abnormal_white_adipose0.78044622
97MP0009384_cardiac_valve_regurgitation0.77742443
98MP0005379_endocrine/exocrine_gland_phen0.76663477
99* MP0005195_abnormal_posterior_eye0.76382575
100MP0002751_abnormal_autonomic_nervous0.76322175
101MP0004085_abnormal_heartbeat0.74525235
102MP0003075_altered_response_to0.73869094
103MP0003937_abnormal_limbs/digits/tail_de0.73796358
104MP0004043_abnormal_pH_regulation0.73721561
105MP0002277_abnormal_respiratory_mucosa0.73003673
106MP0003045_fibrosis0.72797312
107MP0004145_abnormal_muscle_electrophysio0.72744326
108MP0005367_renal/urinary_system_phenotyp0.70085606
109MP0000516_abnormal_urinary_system0.70085606
110MP0004811_abnormal_neuron_physiology0.69963957
111MP0003861_abnormal_nervous_system0.68857951
112MP0001299_abnormal_eye_distance/0.67956318
113MP0000372_irregular_coat_pigmentation0.67889608
114MP0005595_abnormal_vascular_smooth0.67555613
115MP0003137_abnormal_impulse_conducting0.67341388
116MP0000647_abnormal_sebaceous_gland0.66836113
117MP0003183_abnormal_peptide_metabolism0.66593698
118MP0006072_abnormal_retinal_apoptosis0.66385632
119MP0005623_abnormal_meninges_morphology0.66136037
120MP0008872_abnormal_physiological_respon0.65253591
121MP0009278_abnormal_bone_marrow0.61020163
122MP0002090_abnormal_vision0.59164808
123MP0003119_abnormal_digestive_system0.58222633
124MP0002069_abnormal_eating/drinking_beha0.57240043
125MP0003123_paternal_imprinting0.55425284
126MP0000534_abnormal_ureter_morphology0.55382406
127MP0003385_abnormal_body_wall0.54957984

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)6.93183103
2Aplasia of the phalanges of the hand (HP:0009802)4.30230462
3Aplasia involving bones of the extremities (HP:0009825)4.30230462
4Aplasia involving bones of the upper limbs (HP:0009823)4.30230462
5Focal motor seizures (HP:0011153)4.28840743
6Truncal ataxia (HP:0002078)4.07384408
7Hemiplegia (HP:0002301)3.97118855
8Gaze-evoked nystagmus (HP:0000640)3.83264723
9Absence seizures (HP:0002121)3.74981753
10Postural instability (HP:0002172)3.54228331
11Urinary bladder sphincter dysfunction (HP:0002839)3.52279638
12Synostosis involving the elbow (HP:0003938)3.50013734
13Humeroradial synostosis (HP:0003041)3.50013734
14Dysmetric saccades (HP:0000641)3.48602481
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44926947
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.33561318
17Absent/shortened dynein arms (HP:0200106)3.33561318
18Abnormal ciliary motility (HP:0012262)3.24360607
19Neurofibrillary tangles (HP:0002185)3.19751124
20Hemiparesis (HP:0001269)3.12347709
21Febrile seizures (HP:0002373)3.12187755
22Abnormal respiratory motile cilium physiology (HP:0012261)3.03286694
23Megalencephaly (HP:0001355)2.98248871
24Abnormal respiratory epithelium morphology (HP:0012253)2.94719768
25Abnormal respiratory motile cilium morphology (HP:0005938)2.94719768
26Absent speech (HP:0001344)2.93748746
27Split foot (HP:0001839)2.92957047
28Abnormality of the middle phalanges of the toes (HP:0010183)2.92250874
29Hypothermia (HP:0002045)2.92100304
30Abnormality of the axillary hair (HP:0100134)2.89902250
31Abnormality of secondary sexual hair (HP:0009888)2.89902250
32Myokymia (HP:0002411)2.88167253
33Parakeratosis (HP:0001036)2.83307002
34Impaired smooth pursuit (HP:0007772)2.81071962
35Septo-optic dysplasia (HP:0100842)2.79242102
36Focal seizures (HP:0007359)2.75774974
37Nasolacrimal duct obstruction (HP:0000579)2.70881713
38Epileptic encephalopathy (HP:0200134)2.70176273
39Limb dystonia (HP:0002451)2.64769574
40Abnormality of the nasal septum (HP:0000419)2.64559200
41Alacrima (HP:0000522)2.62956911
42White forelock (HP:0002211)2.62240681
43Decreased central vision (HP:0007663)2.59297721
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55205492
45Mixed hearing impairment (HP:0000410)2.54761084
46Patchy hypopigmentation of hair (HP:0011365)2.54215359
47Hyperventilation (HP:0002883)2.52306828
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.50844822
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50321092
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.50321092
51Peripheral hypomyelination (HP:0007182)2.49944234
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49841559
53Hypoplastic left heart (HP:0004383)2.49115456
54Gait imbalance (HP:0002141)2.48820814
55Abnormality of the ischium (HP:0003174)2.46124039
56Atonic seizures (HP:0010819)2.45198608
57Urethral obstruction (HP:0000796)2.43354469
58Diplopia (HP:0000651)2.42947717
59Abnormality of binocular vision (HP:0011514)2.42947717
60Absent septum pellucidum (HP:0001331)2.41380938
61Morphological abnormality of the middle ear (HP:0008609)2.40847473
62Abnormality of ocular smooth pursuit (HP:0000617)2.30744866
63Medial flaring of the eyebrow (HP:0010747)2.30325000
64Congenital primary aphakia (HP:0007707)2.27488563
65Broad-based gait (HP:0002136)2.26486572
66Symphalangism affecting the phalanges of the hand (HP:0009773)2.25882202
67Abnormality of the lacrimal duct (HP:0011481)2.23883760
68Abnormality of the septum pellucidum (HP:0007375)2.23130703
69True hermaphroditism (HP:0010459)2.22018287
70Visual hallucinations (HP:0002367)2.21156225
71Recurrent corneal erosions (HP:0000495)2.20533347
72Protruding tongue (HP:0010808)2.19173124
73Nephrogenic diabetes insipidus (HP:0009806)2.19111019
74Fibular aplasia (HP:0002990)2.18727605
75Hypoplastic ischia (HP:0003175)2.18480983
76Decreased lacrimation (HP:0000633)2.17314780
77Action tremor (HP:0002345)2.15997226
78Generalized tonic-clonic seizures (HP:0002069)2.15894957
79Supranuclear gaze palsy (HP:0000605)2.15451124
80Abnormal eating behavior (HP:0100738)2.13402400
81Cerebral inclusion bodies (HP:0100314)2.11742184
82Insidious onset (HP:0003587)2.11717363
83Termporal pattern (HP:0011008)2.11717363
84Vaginal atresia (HP:0000148)2.09240933
85Genital tract atresia (HP:0001827)2.08871621
86Methylmalonic acidemia (HP:0002912)2.08784829
87Spastic gait (HP:0002064)2.06868689
88Hypoplastic heart (HP:0001961)2.05894632
89Aplasia cutis congenita (HP:0001057)2.05302191
90Abnormality of incisor morphology (HP:0011063)2.04976182
91Clumsiness (HP:0002312)2.02001936
92Abnormality of the nasolacrimal system (HP:0000614)2.00404912
93Impaired vibratory sensation (HP:0002495)1.98894772
94Renal Fanconi syndrome (HP:0001994)1.98826844
95Short tibia (HP:0005736)1.98393474
96Rhinitis (HP:0012384)1.97843936
97Abnormality of the lower motor neuron (HP:0002366)1.97811986
98Polyphagia (HP:0002591)1.96630246
99* Stereotypic behavior (HP:0000733)1.95573571
100Xerostomia (HP:0000217)1.95271530
101Optic nerve hypoplasia (HP:0000609)1.94685836
102Partial duplication of thumb phalanx (HP:0009944)1.94004772
103Short 4th metacarpal (HP:0010044)1.93788196
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93788196
105Ulnar claw (HP:0001178)1.93331809
106Abnormality of the dental pulp (HP:0006479)1.90670249
107Drooling (HP:0002307)1.89911057
108Progressive cerebellar ataxia (HP:0002073)1.88194139
109Increased corneal curvature (HP:0100692)1.87931723
110Keratoconus (HP:0000563)1.87931723
111Abnormality of the corticospinal tract (HP:0002492)1.87613481
112Duplication of thumb phalanx (HP:0009942)1.87504905
113Specific learning disability (HP:0001328)1.87071838
114Tubulointerstitial nephritis (HP:0001970)1.86868304
115Epileptiform EEG discharges (HP:0011182)1.85608940
116Short hallux (HP:0010109)1.85285505
117Dialeptic seizures (HP:0011146)1.85235379
118Abnormality of molar morphology (HP:0011070)1.83471953
119Abnormality of molar (HP:0011077)1.83471953
120Submucous cleft hard palate (HP:0000176)1.81225809
121Poor eye contact (HP:0000817)1.80684117
122Abnormality of the pubic bones (HP:0003172)1.80352227
123Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78587497
124Periauricular skin pits (HP:0100277)1.77070645
125Preauricular pit (HP:0004467)1.77070645
126Conical tooth (HP:0000698)1.76336604
127Onion bulb formation (HP:0003383)1.75766271
128Abnormal hair whorl (HP:0010721)1.75759408
129Cutaneous finger syndactyly (HP:0010554)1.75501231
130Neoplasm of the heart (HP:0100544)1.75449124
131Abnormality of permanent molar morphology (HP:0011071)1.74901746
132Abnormality of the dental root (HP:0006486)1.74901746
133Taurodontia (HP:0000679)1.74901746
134Long nose (HP:0003189)1.74638306
135Ankle clonus (HP:0011448)1.74533581
136Limb ataxia (HP:0002070)1.74379837
137Abnormality of the proximal phalanges of the hand (HP:0009834)1.74343259
138Thickened helices (HP:0000391)1.74063297
139Chronic hepatic failure (HP:0100626)1.73672969
140Dysdiadochokinesis (HP:0002075)1.73215795
141Abnormality of macular pigmentation (HP:0008002)1.72693522
142Abnormality of the 4th metacarpal (HP:0010012)1.71159519
143Bradykinesia (HP:0002067)1.70463562
144Exotropia (HP:0000577)1.70460942
145Severe visual impairment (HP:0001141)1.70419186
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.70260861
147EEG with generalized epileptiform discharges (HP:0011198)1.68710492
148Excessive salivation (HP:0003781)1.67925189
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64871497
150Renal hypoplasia (HP:0000089)1.64402774
151Widely spaced teeth (HP:0000687)1.64089182
152Postural tremor (HP:0002174)1.62642999
153Neuronal loss in central nervous system (HP:0002529)1.61066757
154Increased neuronal autofluorescent lipopigment (HP:0002074)1.60367681
155Short phalanx of the thumb (HP:0009660)1.58577694
156Status epilepticus (HP:0002133)1.57976564
157Male pseudohermaphroditism (HP:0000037)1.57361490
158Hypsarrhythmia (HP:0002521)1.57354819
159Nephronophthisis (HP:0000090)1.57227654
160Oligodactyly (hands) (HP:0001180)1.55622150
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54335074
162Rigidity (HP:0002063)1.52423907
163Central scotoma (HP:0000603)1.51812274
164Dysautonomia (HP:0002459)1.50257132
165Hepatoblastoma (HP:0002884)1.50035704
166Hypoplasia of the corpus callosum (HP:0002079)1.49971387
167Fibular hypoplasia (HP:0003038)1.49761708
168Congenital stationary night blindness (HP:0007642)1.49276411
169Increased cerebral lipofuscin (HP:0011813)1.47647139
170Bony spicule pigmentary retinopathy (HP:0007737)1.47592458
171Abolished electroretinogram (ERG) (HP:0000550)1.46824912
172Dysmetria (HP:0001310)1.46338479
173Tented upper lip vermilion (HP:0010804)1.46131066
174Abnormality of the columella (HP:0009929)1.45639718
175Morphological abnormality of the inner ear (HP:0011390)1.44805015
176Abnormal drinking behavior (HP:0030082)1.43655292
177Polydipsia (HP:0001959)1.43655292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.96540089
2FRK3.64708127
3TNIK3.03957435
4PRPF4B2.74468438
5PRKD32.66833489
6STK392.58184155
7NTRK32.03338187
8BMPR1B2.02375212
9MARK11.99854081
10OXSR11.97926244
11NTRK21.93615797
12INSRR1.89956887
13EPHA41.89438601
14MAPK131.87194641
15PHKG11.86818332
16PHKG21.86818332
17MAP2K71.85158425
18PKN11.82554303
19EPHB21.70837076
20MKNK21.69076807
21GRK71.65547292
22TYRO31.65260721
23BLK1.58005512
24DDR21.55640882
25SIK31.53698067
26SGK2231.53314861
27SGK4941.53314861
28ADRBK21.52468154
29MUSK1.51882070
30STK161.51548494
31MAPKAPK51.47372974
32PBK1.40822878
33CAMK2B1.40460133
34NTRK11.38582439
35PNCK1.36681506
36SIK21.23868811
37FGFR21.23496987
38FGR1.21060499
39YES11.18710434
40IRAK21.18552831
41PTK2B1.16432480
42GRK51.15536835
43PLK21.14342149
44PRKCE1.14027135
45CAMK2A1.13392326
46CAMK2D1.13051347
47EPHB11.13034290
48LMTK21.11025729
49SGK21.07976313
50BCR1.07210295
51TNK21.07043807
52CAMKK11.05886243
53DYRK1A1.02988667
54WNK31.02591857
55MINK11.01660669
56CAMK2G1.01310063
57DYRK20.99962951
58RIPK40.98116093
59MAPK150.95794450
60MAP3K40.92238993
61CDK50.90668110
62ADRBK10.90298410
63CAMK1D0.90149678
64ERBB20.89925317
65UHMK10.86459787
66BMPR20.85323021
67WNK40.84399047
68IRAK10.83463354
69AKT30.80852529
70ROCK20.78456784
71PRKCH0.77505847
72MOS0.77494084
73FES0.76591712
74CAMK40.75692847
75CLK10.75280270
76ARAF0.74561803
77DAPK20.73483643
78PAK30.73222431
79CDK30.72863599
80PAK60.71314247
81MET0.70601917
82LIMK10.70096628
83CDK150.70044877
84WNK10.69747125
85MKNK10.69207419
86PINK10.67969402
87DAPK10.66554020
88NEK60.66489452
89GRK10.64379795
90PRKCG0.64375219
91CDK180.64252936
92ERBB40.62533029
93CDK190.61300290
94CDK140.61077852
95CDK11A0.60456266
96MAPK120.59872472
97PRKG10.58869165
98MAP3K90.55013123
99PRKACA0.54101174
100CSNK1G20.54082650
101CSNK1G10.53562172
102MAP3K130.53024957
103CSNK1A1L0.52111591
104PDGFRA0.49040512
105MARK20.48043755
106CSNK1G30.47544345
107CDK80.46392528
108PIK3CA0.45717371
109PRKCQ0.45716867
110PRKCZ0.44961115
111RPS6KA30.43499387
112STK38L0.43119614
113EGFR0.42951903
114SGK10.42127170
115MAP3K140.41699377
116NEK20.41175047
117CAMK1G0.40353557
118MAP2K40.40032343
119MAPK100.39975220
120ICK0.39040266
121CSNK1A10.38549809
122FYN0.38308305
123STK110.37474037
124STK380.37306287
125ROCK10.37284651
126FER0.36558766
127PRKCA0.36461079
128CAMK10.36437534
129NEK90.36110444
130ERBB30.35703771
131PDGFRB0.34543576
132BRAF0.34397094
133ABL20.34275591
134SGK30.33827575
135BMX0.33797897
136CSNK1D0.33234707
137TAOK10.32391316
138GSK3A0.32244200
139PRKCB0.32022655

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02724658
2Olfactory transduction_Homo sapiens_hsa047402.57089938
3Glutamatergic synapse_Homo sapiens_hsa047242.37549274
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26089254
5Morphine addiction_Homo sapiens_hsa050322.23225007
6GABAergic synapse_Homo sapiens_hsa047272.22217769
7Nitrogen metabolism_Homo sapiens_hsa009102.10817130
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09652856
9Fatty acid elongation_Homo sapiens_hsa000622.03982556
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00178039
11Fatty acid biosynthesis_Homo sapiens_hsa000611.99754617
12Serotonergic synapse_Homo sapiens_hsa047261.99207018
13Phototransduction_Homo sapiens_hsa047441.96070448
14Taste transduction_Homo sapiens_hsa047421.95518693
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90127313
16Circadian entrainment_Homo sapiens_hsa047131.88840272
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81532336
18Salivary secretion_Homo sapiens_hsa049701.76694533
19Ether lipid metabolism_Homo sapiens_hsa005651.75913586
20Steroid biosynthesis_Homo sapiens_hsa001001.73474518
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69675683
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56278590
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54811311
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52813652
25Insulin secretion_Homo sapiens_hsa049111.52213826
26Oxidative phosphorylation_Homo sapiens_hsa001901.50480242
27Synaptic vesicle cycle_Homo sapiens_hsa047211.48778265
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48040347
29Dopaminergic synapse_Homo sapiens_hsa047281.41856772
30Axon guidance_Homo sapiens_hsa043601.41481895
31Gastric acid secretion_Homo sapiens_hsa049711.41095915
32Collecting duct acid secretion_Homo sapiens_hsa049661.40967800
33Cholinergic synapse_Homo sapiens_hsa047251.38696933
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36099966
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.35467826
36Estrogen signaling pathway_Homo sapiens_hsa049151.35170434
37Sphingolipid metabolism_Homo sapiens_hsa006001.32397503
38Calcium signaling pathway_Homo sapiens_hsa040201.31753534
39Amphetamine addiction_Homo sapiens_hsa050311.30143903
40Long-term depression_Homo sapiens_hsa047301.23772606
41Cocaine addiction_Homo sapiens_hsa050301.22238699
42Renin secretion_Homo sapiens_hsa049241.18119617
43Alzheimers disease_Homo sapiens_hsa050101.08908188
44beta-Alanine metabolism_Homo sapiens_hsa004101.08892301
45cAMP signaling pathway_Homo sapiens_hsa040241.06878546
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04838103
47Lysine degradation_Homo sapiens_hsa003101.02713980
48Long-term potentiation_Homo sapiens_hsa047200.99070780
49Mineral absorption_Homo sapiens_hsa049780.97571555
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93766170
51Pancreatic secretion_Homo sapiens_hsa049720.90386280
52African trypanosomiasis_Homo sapiens_hsa051430.89953836
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89491482
54Parkinsons disease_Homo sapiens_hsa050120.87905028
55Sulfur metabolism_Homo sapiens_hsa009200.86166368
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85294805
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.84272241
58Glioma_Homo sapiens_hsa052140.83996604
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82845154
60Cardiac muscle contraction_Homo sapiens_hsa042600.82260581
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81973890
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81707916
63PPAR signaling pathway_Homo sapiens_hsa033200.81501210
64Rheumatoid arthritis_Homo sapiens_hsa053230.81025370
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80914439
66Linoleic acid metabolism_Homo sapiens_hsa005910.80301976
67Ras signaling pathway_Homo sapiens_hsa040140.79892157
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78774273
69Oxytocin signaling pathway_Homo sapiens_hsa049210.78217424
70Bile secretion_Homo sapiens_hsa049760.77320076
71Propanoate metabolism_Homo sapiens_hsa006400.76542852
72Notch signaling pathway_Homo sapiens_hsa043300.76390900
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75966674
74Dorso-ventral axis formation_Homo sapiens_hsa043200.75898227
75Melanogenesis_Homo sapiens_hsa049160.75633246
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75323184
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72636301
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71086421
79Ovarian steroidogenesis_Homo sapiens_hsa049130.67591130
80Type II diabetes mellitus_Homo sapiens_hsa049300.67108704
81Hedgehog signaling pathway_Homo sapiens_hsa043400.65942931
82Histidine metabolism_Homo sapiens_hsa003400.65715550
83Gap junction_Homo sapiens_hsa045400.65324341
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64984573
85Arachidonic acid metabolism_Homo sapiens_hsa005900.62613404
86Huntingtons disease_Homo sapiens_hsa050160.62514719
87Circadian rhythm_Homo sapiens_hsa047100.60479984
88Wnt signaling pathway_Homo sapiens_hsa043100.59097450
89Autoimmune thyroid disease_Homo sapiens_hsa053200.59041776
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58694968
91Vibrio cholerae infection_Homo sapiens_hsa051100.57543042
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.57278409
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57227773
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.55830697
95Rap1 signaling pathway_Homo sapiens_hsa040150.55110869
96Prion diseases_Homo sapiens_hsa050200.55031759
97GnRH signaling pathway_Homo sapiens_hsa049120.54967661
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54596592
99Basal cell carcinoma_Homo sapiens_hsa052170.54300512
100Dilated cardiomyopathy_Homo sapiens_hsa054140.53538944
101Type I diabetes mellitus_Homo sapiens_hsa049400.52844199
102Arginine and proline metabolism_Homo sapiens_hsa003300.51874139
103Melanoma_Homo sapiens_hsa052180.50431512
104Graft-versus-host disease_Homo sapiens_hsa053320.50028246
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49719130
106Tryptophan metabolism_Homo sapiens_hsa003800.49053076
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46167328
108Phagosome_Homo sapiens_hsa041450.45262561
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44114121
110ABC transporters_Homo sapiens_hsa020100.43888074
111ErbB signaling pathway_Homo sapiens_hsa040120.41858509
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40027676
113Choline metabolism in cancer_Homo sapiens_hsa052310.39711224
114Fatty acid metabolism_Homo sapiens_hsa012120.39337471
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39291508
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38727294
117Thyroid hormone synthesis_Homo sapiens_hsa049180.38389082
118Butanoate metabolism_Homo sapiens_hsa006500.37291757
119MAPK signaling pathway_Homo sapiens_hsa040100.36857169
120Oocyte meiosis_Homo sapiens_hsa041140.36418649
121Glycerolipid metabolism_Homo sapiens_hsa005610.34550483
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.30536951
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29040531
124Hippo signaling pathway_Homo sapiens_hsa043900.26045167

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