NDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.30513598
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.92916639
3response to pheromone (GO:0019236)4.89171176
4synaptic vesicle exocytosis (GO:0016079)4.83147632
5vocalization behavior (GO:0071625)4.64200182
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62344553
7protein localization to synapse (GO:0035418)4.52135313
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51481976
9establishment of mitochondrion localization (GO:0051654)4.36103199
10* neuron recognition (GO:0008038)4.26264842
11regulation of synaptic vesicle exocytosis (GO:2000300)4.22411882
12regulation of glutamate receptor signaling pathway (GO:1900449)4.22079504
13synaptic vesicle maturation (GO:0016188)4.12247869
14locomotory exploration behavior (GO:0035641)4.03059759
15behavioral response to nicotine (GO:0035095)4.02019287
16layer formation in cerebral cortex (GO:0021819)4.01336744
17pyrimidine nucleobase catabolic process (GO:0006208)3.95281326
18glutamate secretion (GO:0014047)3.92489087
19positive regulation of synapse assembly (GO:0051965)3.88390006
20neurotransmitter secretion (GO:0007269)3.87913188
21exploration behavior (GO:0035640)3.87399592
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.86170948
23regulation of glutamate secretion (GO:0014048)3.83136992
24dendritic spine morphogenesis (GO:0060997)3.83065005
25negative regulation of microtubule polymerization (GO:0031115)3.77906274
26regulation of synaptic vesicle transport (GO:1902803)3.76599935
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.70385830
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69103986
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64137699
30mitochondrion transport along microtubule (GO:0047497)3.63931043
31establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.63931043
32glutamate receptor signaling pathway (GO:0007215)3.61592166
33proline transport (GO:0015824)3.54920784
34transmission of nerve impulse (GO:0019226)3.47983289
35neuronal action potential propagation (GO:0019227)3.46999276
36* axonal fasciculation (GO:0007413)3.45650056
37neuromuscular process controlling posture (GO:0050884)3.45636195
38mating behavior (GO:0007617)3.45396231
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.44887728
40neurofilament cytoskeleton organization (GO:0060052)3.40760936
41cell migration in hindbrain (GO:0021535)3.36977378
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36490072
43neurotransmitter transport (GO:0006836)3.35395419
44retinal ganglion cell axon guidance (GO:0031290)3.35099478
45nucleobase catabolic process (GO:0046113)3.31103342
46synaptic transmission, glutamatergic (GO:0035249)3.29781400
47regulation of synapse structural plasticity (GO:0051823)3.29548179
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29297627
49nonmotile primary cilium assembly (GO:0035058)3.28094182
50axon extension involved in axon guidance (GO:0048846)3.27512644
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.27512644
52activation of protein kinase A activity (GO:0034199)3.26936217
53neuron-neuron synaptic transmission (GO:0007270)3.25819611
54regulation of neuronal synaptic plasticity (GO:0048168)3.24119189
55postsynaptic membrane organization (GO:0001941)3.23902640
56dendrite morphogenesis (GO:0048813)3.22176994
57regulation of vesicle fusion (GO:0031338)3.20539213
58synaptic vesicle endocytosis (GO:0048488)3.17710264
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17609658
60regulation of synapse assembly (GO:0051963)3.17493966
61positive regulation of gastrulation (GO:2000543)3.15301235
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13985540
63auditory behavior (GO:0031223)3.11401393
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10532665
65synapse assembly (GO:0007416)3.09623205
66* axon extension (GO:0048675)3.08754164
67regulation of neurotransmitter levels (GO:0001505)3.07118148
68negative regulation of amino acid transport (GO:0051956)3.02637833
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02598013
70positive regulation of amino acid transport (GO:0051957)3.02473325
71response to histamine (GO:0034776)3.02348371
72cerebellar Purkinje cell differentiation (GO:0021702)2.99195117
73presynaptic membrane assembly (GO:0097105)2.98881627
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96723398
75adult feeding behavior (GO:0008343)2.96182989
76short-term memory (GO:0007614)2.94271504
77dendrite development (GO:0016358)2.91587531
78opioid receptor signaling pathway (GO:0038003)2.91164479
79long-term memory (GO:0007616)2.90479206
80intraspecies interaction between organisms (GO:0051703)2.89096999
81social behavior (GO:0035176)2.89096999
82regulation of respiratory system process (GO:0044065)2.88288115
83presynaptic membrane organization (GO:0097090)2.88134077
84regulation of postsynaptic membrane potential (GO:0060078)2.86551027
85cerebellar Purkinje cell layer development (GO:0021680)2.86154856
86regulation of synaptic transmission, GABAergic (GO:0032228)2.85489815
87membrane hyperpolarization (GO:0060081)2.84475973
88neuron fate determination (GO:0048664)2.83807483
89cerebral cortex radially oriented cell migration (GO:0021799)2.83786224
90central nervous system projection neuron axonogenesis (GO:0021952)2.83330765
91synaptic vesicle transport (GO:0048489)2.83267857
92establishment of synaptic vesicle localization (GO:0097480)2.83267857
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83265781
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83203385
95regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82604343
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82036103
97synapse organization (GO:0050808)2.80765324
98chaperone-mediated protein transport (GO:0072321)2.80297759
99calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.80210440
100gamma-aminobutyric acid transport (GO:0015812)2.79906046
101regulation of synapse organization (GO:0050807)2.79755829
102response to auditory stimulus (GO:0010996)2.79583924
103neuronal ion channel clustering (GO:0045161)2.79133781
104adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79020978
105spinal cord development (GO:0021510)2.78375567
106dopamine receptor signaling pathway (GO:0007212)2.77844669
107prepulse inhibition (GO:0060134)2.77806690
108behavioral defense response (GO:0002209)2.77583433
109behavioral fear response (GO:0001662)2.77583433
110somite development (GO:0061053)2.76572050
111regulation of neurotransmitter secretion (GO:0046928)2.76514091
112regulation of synaptic transmission, glutamatergic (GO:0051966)2.75527550
113spinal cord association neuron differentiation (GO:0021527)2.74727099
114ATP synthesis coupled proton transport (GO:0015986)2.74426648
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74426648
116positive regulation of membrane potential (GO:0045838)2.73299567
117positive regulation of synapse maturation (GO:0090129)2.72623040
118fear response (GO:0042596)2.71866989
119substrate-independent telencephalic tangential migration (GO:0021826)2.71657521
120substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71657521
121regulation of protein kinase A signaling (GO:0010738)2.71310905
122establishment of vesicle localization (GO:0051650)2.71142007
123hippocampus development (GO:0021766)2.71002310
124negative regulation of axon guidance (GO:1902668)2.70818668
125sequestering of actin monomers (GO:0042989)2.69854093
126negative regulation of axonogenesis (GO:0050771)2.69799343
127mechanosensory behavior (GO:0007638)2.69710410
128glycosphingolipid biosynthetic process (GO:0006688)2.68433658
129startle response (GO:0001964)2.66539287
130negative regulation of axon extension (GO:0030517)2.65412591
131neurotransmitter-gated ion channel clustering (GO:0072578)2.63458956
132head development (GO:0060322)2.61973816
133regulation of axon guidance (GO:1902667)2.54065100
134epithelial cell differentiation involved in kidney development (GO:0035850)2.54015232
135adult walking behavior (GO:0007628)2.51386497
136synaptic transmission, cholinergic (GO:0007271)2.49089511
137cell proliferation in forebrain (GO:0021846)2.47442358
138* neuron projection extension (GO:1990138)2.46146920
139neuromuscular synaptic transmission (GO:0007274)2.46066688
140protein localization to cilium (GO:0061512)2.38480067
141membrane depolarization during action potential (GO:0086010)2.38341449
142response to dietary excess (GO:0002021)2.38340755
143establishment of nucleus localization (GO:0040023)2.38326190
144limb bud formation (GO:0060174)2.34372995
145forebrain neuron differentiation (GO:0021879)2.33807153
146* neuron migration (GO:0001764)2.32526310
147axon cargo transport (GO:0008088)2.31730728
148protein polyglutamylation (GO:0018095)2.30806730
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.30272754
150otic vesicle formation (GO:0030916)2.29647402
151axon ensheathment in central nervous system (GO:0032291)2.28254121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.72877249
2GBX2_23144817_ChIP-Seq_PC3_Human3.29940495
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11536077
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.11508676
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09233846
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00221825
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.89836786
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.77341868
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76713803
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76006903
11REST_21632747_ChIP-Seq_MESCs_Mouse2.70042280
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68033425
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62991339
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62991339
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60101559
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.54246159
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53648391
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46742853
19TAF15_26573619_Chip-Seq_HEK293_Human2.40313546
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.40146125
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39581443
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38835452
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23805975
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.18870077
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16073811
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14542958
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.13596709
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08650086
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02726467
30ZNF274_21170338_ChIP-Seq_K562_Hela1.97918344
31IGF1R_20145208_ChIP-Seq_DFB_Human1.97517274
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90959635
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.90507827
34AR_21572438_ChIP-Seq_LNCaP_Human1.86684924
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.83450922
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79507686
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78838576
38DROSHA_22980978_ChIP-Seq_HELA_Human1.75945964
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69838740
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.66360886
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55680875
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55534938
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55422912
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55032716
45P300_19829295_ChIP-Seq_ESCs_Human1.54374188
46SMAD4_21799915_ChIP-Seq_A2780_Human1.50570584
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.42713858
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.39750739
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39408493
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33432919
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.33158030
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.28299179
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27362298
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25029829
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23832034
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22806796
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22278947
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21760971
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21572265
60VDR_22108803_ChIP-Seq_LS180_Human1.20737527
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20670761
62AR_25329375_ChIP-Seq_VCAP_Human1.20394487
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.18433273
64FUS_26573619_Chip-Seq_HEK293_Human1.17933122
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.16638229
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16591925
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15700129
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12495314
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09505006
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09316048
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09046571
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09037300
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.08525056
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05228491
75JUN_21703547_ChIP-Seq_K562_Human1.03817792
76RUNX2_22187159_ChIP-Seq_PCA_Human1.03705250
77ER_23166858_ChIP-Seq_MCF-7_Human1.03535844
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02555268
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01907859
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01578922
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01303683
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00567320
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00248567
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99641441
85CTCF_27219007_Chip-Seq_Bcells_Human0.99057680
86AR_19668381_ChIP-Seq_PC3_Human0.98676111
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98430328
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96708001
89STAT3_23295773_ChIP-Seq_U87_Human0.95750715
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95637501
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95556433
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94686765
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.94061956
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93854366
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93854366
96* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93260864
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91903563
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91526030
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90232803
100* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90166157
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89332172
102EWS_26573619_Chip-Seq_HEK293_Human0.89161511
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88957975
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88847992
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88014836
106* TCF4_23295773_ChIP-Seq_U87_Human0.86314302
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85117831
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.85027382
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84691662
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84376727
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.83843574
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83314799
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.82802538
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82694024
115CBP_20019798_ChIP-Seq_JUKART_Human0.82694024
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82139559
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80925512
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80910522
119REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80512631
120KDM2B_26808549_Chip-Seq_REH_Human0.80140678
121BCAT_22108803_ChIP-Seq_LS180_Human0.78236133
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78114121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.07642138
2MP0004859_abnormal_synaptic_plasticity4.20280692
3MP0003635_abnormal_synaptic_transmissio3.44007811
4MP0005423_abnormal_somatic_nervous3.32570997
5* MP0006276_abnormal_autonomic_nervous3.26526506
6MP0005645_abnormal_hypothalamus_physiol3.21045093
7MP0001968_abnormal_touch/_nociception3.16255673
8* MP0003122_maternal_imprinting3.13229059
9MP0009745_abnormal_behavioral_response2.86877865
10MP0004270_analgesia2.85148457
11* MP0002063_abnormal_learning/memory/cond2.82075973
12MP0002064_seizures2.70061569
13MP0002572_abnormal_emotion/affect_behav2.57079894
14MP0009046_muscle_twitch2.50280971
15MP0002734_abnormal_mechanical_nocicepti2.48108853
16MP0001529_abnormal_vocalization2.48006206
17MP0002736_abnormal_nociception_after2.38250532
18MP0000778_abnormal_nervous_system2.37816367
19MP0002735_abnormal_chemical_nociception2.32001373
20* MP0002272_abnormal_nervous_system2.14795838
21MP0002653_abnormal_ependyma_morphology2.13624358
22MP0001486_abnormal_startle_reflex2.08044099
23* MP0001440_abnormal_grooming_behavior2.06520685
24* MP0002733_abnormal_thermal_nociception2.05051094
25MP0001501_abnormal_sleep_pattern2.03415283
26MP0002067_abnormal_sensory_capabilities1.95205911
27* MP0002184_abnormal_innervation1.94250568
28MP0002557_abnormal_social/conspecific_i1.94248788
29MP0001984_abnormal_olfaction1.92829896
30* MP0001970_abnormal_pain_threshold1.88488507
31MP0006292_abnormal_olfactory_placode1.83280941
32MP0003123_paternal_imprinting1.82190799
33MP0001905_abnormal_dopamine_level1.80670166
34MP0005386_behavior/neurological_phenoty1.80183195
35MP0004924_abnormal_behavior1.80183195
36MP0001502_abnormal_circadian_rhythm1.65609728
37MP0000566_synostosis1.65493577
38MP0003329_amyloid_beta_deposits1.62316972
39MP0000751_myopathy1.60038254
40MP0000049_abnormal_middle_ear1.51584057
41MP0002822_catalepsy1.50683478
42MP0003136_yellow_coat_color1.50232214
43MP0004811_abnormal_neuron_physiology1.50057355
44MP0000955_abnormal_spinal_cord1.49709387
45* MP0003121_genomic_imprinting1.49685155
46MP0005646_abnormal_pituitary_gland1.49662454
47MP0008789_abnormal_olfactory_epithelium1.49548838
48MP0002909_abnormal_adrenal_gland1.47570833
49MP0003787_abnormal_imprinting1.45524460
50* MP0002882_abnormal_neuron_morphology1.41646395
51MP0003890_abnormal_embryonic-extraembry1.39517350
52MP0008877_abnormal_DNA_methylation1.37131686
53MP0002638_abnormal_pupillary_reflex1.34701259
54MP0000631_abnormal_neuroendocrine_gland1.34352077
55MP0004858_abnormal_nervous_system1.33450072
56* MP0002066_abnormal_motor_capabilities/c1.31580951
57MP0002938_white_spotting1.30166554
58MP0003011_delayed_dark_adaptation1.30047526
59MP0003942_abnormal_urinary_system1.28949038
60MP0001188_hyperpigmentation1.26817997
61MP0002837_dystrophic_cardiac_calcinosis1.26022923
62MP0010386_abnormal_urinary_bladder1.23828072
63MP0006072_abnormal_retinal_apoptosis1.17590958
64MP0008569_lethality_at_weaning1.16382460
65* MP0004142_abnormal_muscle_tone1.15892231
66* MP0002152_abnormal_brain_morphology1.15813245
67MP0010030_abnormal_orbit_morphology1.11691167
68MP0004742_abnormal_vestibular_system1.09674219
69MP0000534_abnormal_ureter_morphology1.05485469
70MP0001293_anophthalmia1.04658747
71MP0002069_abnormal_eating/drinking_beha1.03040866
72MP0003938_abnormal_ear_development1.01307006
73MP0005503_abnormal_tendon_morphology1.01214600
74MP0001485_abnormal_pinna_reflex0.99654824
75MP0003119_abnormal_digestive_system0.99610088
76MP0005551_abnormal_eye_electrophysiolog0.99333498
77MP0002233_abnormal_nose_morphology0.97270313
78MP0008961_abnormal_basal_metabolism0.95403641
79MP0002751_abnormal_autonomic_nervous0.95272654
80MP0004145_abnormal_muscle_electrophysio0.95065741
81* MP0002752_abnormal_somatic_nervous0.93236570
82MP0000013_abnormal_adipose_tissue0.93201581
83MP0005195_abnormal_posterior_eye0.90910366
84MP0000569_abnormal_digit_pigmentation0.90609396
85MP0009780_abnormal_chondrocyte_physiolo0.86755546
86MP0005084_abnormal_gallbladder_morpholo0.86108306
87MP0002876_abnormal_thyroid_physiology0.84320623
88MP0003385_abnormal_body_wall0.84031986
89MP0003879_abnormal_hair_cell0.83045636
90MP0005535_abnormal_body_temperature0.82937686
91MP0002229_neurodegeneration0.82890195
92MP0005499_abnormal_olfactory_system0.81566898
93MP0005394_taste/olfaction_phenotype0.81566898
94MP0001963_abnormal_hearing_physiology0.80604902
95MP0003937_abnormal_limbs/digits/tail_de0.79330353
96MP0002928_abnormal_bile_duct0.79023847
97MP0003755_abnormal_palate_morphology0.79008184
98MP0003283_abnormal_digestive_organ0.78495143
99MP0003861_abnormal_nervous_system0.78326892
100MP0003634_abnormal_glial_cell0.78312695
101MP0002102_abnormal_ear_morphology0.77883712
102MP0004885_abnormal_endolymph0.77529355
103MP0008872_abnormal_physiological_respon0.77359101
104MP0009384_cardiac_valve_regurgitation0.76868488
105MP0008995_early_reproductive_senescence0.76486798
106MP0002234_abnormal_pharynx_morphology0.75860759
107MP0003959_abnormal_lean_body0.75504760
108MP0003137_abnormal_impulse_conducting0.75354615
109MP0003633_abnormal_nervous_system0.74116329
110MP0000538_abnormal_urinary_bladder0.73370875
111MP0004085_abnormal_heartbeat0.73305414
112MP0001986_abnormal_taste_sensitivity0.73004341
113MP0004133_heterotaxia0.71934503
114MP0002116_abnormal_craniofacial_bone0.71749726
115MP0002249_abnormal_larynx_morphology0.71194408
116MP0002163_abnormal_gland_morphology0.71188453
117MP0001286_abnormal_eye_development0.71022367
118MP0003631_nervous_system_phenotype0.70953196
119MP0000026_abnormal_inner_ear0.70185624
120MP0009379_abnormal_foot_pigmentation0.70069461
121MP0001299_abnormal_eye_distance/0.69678060
122MP0005253_abnormal_eye_physiology0.69598563
123MP0000537_abnormal_urethra_morphology0.68080521
124MP0005448_abnormal_energy_balance0.68027249
125MP0005379_endocrine/exocrine_gland_phen0.67686111
126MP0001664_abnormal_digestion0.65817263
127MP0005623_abnormal_meninges_morphology0.62091923
128MP0005409_darkened_coat_color0.61546686
129MP0000462_abnormal_digestive_system0.61112236
130* MP0001943_abnormal_respiration0.60924068
131MP0000604_amyloidosis0.56496481

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.88800433
2Myokymia (HP:0002411)5.18788430
3Focal seizures (HP:0007359)4.89617354
4Visual hallucinations (HP:0002367)4.57090543
5Atonic seizures (HP:0010819)4.48761764
6Limb dystonia (HP:0002451)4.20751555
7Absence seizures (HP:0002121)3.85854112
8Epileptic encephalopathy (HP:0200134)3.85483429
9Progressive cerebellar ataxia (HP:0002073)3.75759678
10Febrile seizures (HP:0002373)3.67175955
11Supranuclear gaze palsy (HP:0000605)3.58593177
12* Polyphagia (HP:0002591)3.48354287
13Dialeptic seizures (HP:0011146)3.45310709
14Generalized tonic-clonic seizures (HP:0002069)3.29501289
15Molar tooth sign on MRI (HP:0002419)3.18987830
16Abnormality of midbrain morphology (HP:0002418)3.18987830
17Agitation (HP:0000713)3.15404298
18Ankle clonus (HP:0011448)3.10826724
19True hermaphroditism (HP:0010459)3.06802659
20Gait imbalance (HP:0002141)3.03692009
21Progressive inability to walk (HP:0002505)2.99808738
22Mutism (HP:0002300)2.95232046
23* Abnormal eating behavior (HP:0100738)2.92470638
24Pheochromocytoma (HP:0002666)2.90999934
25Broad-based gait (HP:0002136)2.89495133
26Nephronophthisis (HP:0000090)2.86473181
27Amblyopia (HP:0000646)2.85322013
28Anxiety (HP:0000739)2.83997259
29Septo-optic dysplasia (HP:0100842)2.82649501
30Drooling (HP:0002307)2.80610229
31Excessive salivation (HP:0003781)2.80610229
32Pancreatic fibrosis (HP:0100732)2.77277579
33Neurofibrillary tangles (HP:0002185)2.74104850
34Pachygyria (HP:0001302)2.71923159
35Truncal ataxia (HP:0002078)2.69104305
36Hemiparesis (HP:0001269)2.63478287
37Depression (HP:0000716)2.62517551
38Cerebral inclusion bodies (HP:0100314)2.61308151
39Neuroendocrine neoplasm (HP:0100634)2.60171965
40Lissencephaly (HP:0001339)2.57714492
41Acute necrotizing encephalopathy (HP:0006965)2.54228493
42Hypoplasia of the brainstem (HP:0002365)2.52233910
43Aplasia/Hypoplasia of the brainstem (HP:0007362)2.52233910
44Pancreatic cysts (HP:0001737)2.49478710
45* Failure to thrive in infancy (HP:0001531)2.49459966
46Impaired vibration sensation in the lower limbs (HP:0002166)2.47091556
47Congenital primary aphakia (HP:0007707)2.42717664
48Abnormality of the corticospinal tract (HP:0002492)2.41756903
49Medial flaring of the eyebrow (HP:0010747)2.39294341
50Amyotrophic lateral sclerosis (HP:0007354)2.36386298
51Abnormal ciliary motility (HP:0012262)2.35249482
52Spastic gait (HP:0002064)2.34606716
53Hyperthyroidism (HP:0000836)2.34199041
54Urinary urgency (HP:0000012)2.33118251
55Shoulder girdle muscle weakness (HP:0003547)2.32660171
56Abnormal mitochondria in muscle tissue (HP:0008316)2.30243047
57EEG with generalized epileptiform discharges (HP:0011198)2.30222150
58Spastic tetraplegia (HP:0002510)2.30169203
59Poor coordination (HP:0002370)2.29745308
60Epileptiform EEG discharges (HP:0011182)2.29280175
61Hyperventilation (HP:0002883)2.28717226
62Retinal dysplasia (HP:0007973)2.27572988
63Progressive macrocephaly (HP:0004481)2.27276470
64* Esotropia (HP:0000565)2.26106560
65Termporal pattern (HP:0011008)2.25473544
66Insidious onset (HP:0003587)2.25473544
67Rib fusion (HP:0000902)2.25185713
68Action tremor (HP:0002345)2.24631130
69Nephrogenic diabetes insipidus (HP:0009806)2.24044175
70Anophthalmia (HP:0000528)2.21053094
71Hypsarrhythmia (HP:0002521)2.18573432
72Inability to walk (HP:0002540)2.15495204
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15306110
74Poor eye contact (HP:0000817)2.12357006
75Papilledema (HP:0001085)2.12262357
76Exotropia (HP:0000577)2.12164356
77Abnormality of the renal medulla (HP:0100957)2.12066301
78* Specific learning disability (HP:0001328)2.12026398
79Sclerocornea (HP:0000647)2.09288956
80Dysdiadochokinesis (HP:0002075)2.08910796
81Dysmetria (HP:0001310)2.08163724
82Genital tract atresia (HP:0001827)2.07359462
83Abnormal respiratory motile cilium morphology (HP:0005938)2.07256266
84Abnormal respiratory epithelium morphology (HP:0012253)2.07256266
85Vaginal atresia (HP:0000148)2.06955010
86Hypothermia (HP:0002045)2.04978010
87Menstrual irregularities (HP:0000858)2.04242652
88Chronic hepatic failure (HP:0100626)2.03374579
89Lower limb muscle weakness (HP:0007340)2.03057557
90Cortical dysplasia (HP:0002539)1.97962322
91Urinary bladder sphincter dysfunction (HP:0002839)1.97606352
92Absent speech (HP:0001344)1.97177006
93Type II lissencephaly (HP:0007260)1.96935594
94Genetic anticipation (HP:0003743)1.96815835
95Mitochondrial inheritance (HP:0001427)1.96732103
96Optic nerve hypoplasia (HP:0000609)1.96229892
97Postaxial hand polydactyly (HP:0001162)1.96131188
98Hepatoblastoma (HP:0002884)1.94402834
99Fetal akinesia sequence (HP:0001989)1.93643300
100* Narrow forehead (HP:0000341)1.93346396
101Occipital encephalocele (HP:0002085)1.93062230
102Anencephaly (HP:0002323)1.92949044
103Morphological abnormality of the pyramidal tract (HP:0002062)1.92413721
104Open mouth (HP:0000194)1.92348148
105Abnormal respiratory motile cilium physiology (HP:0012261)1.90422041
106Torticollis (HP:0000473)1.90216873
107Bradykinesia (HP:0002067)1.89810235
108Protruding tongue (HP:0010808)1.89083768
109Impaired social interactions (HP:0000735)1.89059310
110Abnormal social behavior (HP:0012433)1.89059310
111Scanning speech (HP:0002168)1.89004420
112Left ventricular hypertrophy (HP:0001712)1.87422593
113Delayed gross motor development (HP:0002194)1.87085682
114Broad foot (HP:0001769)1.87045446
115Oligodactyly (hands) (HP:0001180)1.85998247
116Cystic liver disease (HP:0006706)1.85581823
117Absent septum pellucidum (HP:0001331)1.85315062
118Maternal diabetes (HP:0009800)1.84917168
119Akinesia (HP:0002304)1.84789062
120Aplasia/Hypoplasia of the lens (HP:0008063)1.84010923
121Anomalous pulmonary venous return (HP:0010772)1.83060754
122Abnormality of salivation (HP:0100755)1.82643719
123* Hypoventilation (HP:0002791)1.82593768
124Shawl scrotum (HP:0000049)1.82143601
125Generalized myoclonic seizures (HP:0002123)1.82068301
126Male pseudohermaphroditism (HP:0000037)1.80923611
127* Psychosis (HP:0000709)1.80849162
128Focal dystonia (HP:0004373)1.80126052
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.80002188
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80002188
131Megalencephaly (HP:0001355)1.79412554
132Diplopia (HP:0000651)1.77232093
133Abnormality of binocular vision (HP:0011514)1.77232093
134Myotonia (HP:0002486)1.76902422
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.76599439
136Congenital stationary night blindness (HP:0007642)1.73891118
137Status epilepticus (HP:0002133)1.73071177
138Humeroradial synostosis (HP:0003041)1.71362904
139Synostosis involving the elbow (HP:0003938)1.71362904
140Hypoplasia of the corpus callosum (HP:0002079)1.67816071
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66843602
142Abnormality of the pulmonary veins (HP:0011718)1.66226342
143Acute encephalopathy (HP:0006846)1.65973279
144* Poor suck (HP:0002033)1.62892757
145Ulnar claw (HP:0001178)1.62181227
146Increased corneal curvature (HP:0100692)1.62145936
147Keratoconus (HP:0000563)1.62145936
148Morphological abnormality of the middle ear (HP:0008609)1.61228157
149* Micropenis (HP:0000054)1.60224912
150Hyperglycinemia (HP:0002154)1.59153358
151Abnormality of the aortic arch (HP:0012303)1.58390670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.45284355
2MAP3K94.00454155
3NTRK33.74956465
4MAP3K123.34258777
5MAP3K42.95366199
6NTRK22.90917244
7MINK12.73058654
8MAP2K72.49856101
9PINK12.48991060
10PNCK2.42656317
11CASK2.26171647
12MAPK132.14133298
13UHMK12.01292925
14MAP2K41.97613345
15EPHA41.97607871
16MAPK151.93692792
17KSR11.88240917
18ARAF1.86349437
19MAP4K21.85927418
20WNK31.74042335
21TNIK1.73605988
22PAK61.72751973
23PHKG11.52308033
24PHKG21.52308033
25BCR1.49828397
26CDK191.48444169
27SIK21.48367763
28NTRK11.45987383
29DYRK21.43190971
30CDK51.38847978
31KSR21.32420923
32GRK51.32263093
33PLK21.26363153
34SIK31.25822165
35PAK31.25324256
36DYRK31.16900562
37NME11.15980438
38DAPK21.15880549
39LATS21.15769133
40TYRO31.14685672
41CSNK1G21.12456900
42STK161.10625122
43CDK141.09637938
44CDK181.08961944
45TRIM281.07807272
46GRK71.06002664
47CAMK2A1.04508925
48LIMK11.02632745
49PRKCG1.01743904
50CDK151.01697713
51GRK11.01282605
52DYRK1B1.00615221
53CSNK1G30.98516548
54DYRK1A0.92815370
55BCKDK0.90750777
56CDK11A0.89997965
57TIE10.83166373
58OXSR10.82745584
59FES0.80958759
60ERBB30.80599119
61ADRBK20.80538403
62EPHA30.80073648
63CAMK2B0.80012071
64ADRBK10.76861018
65FER0.76844009
66EPHB20.72034975
67CAMKK20.71576665
68DMPK0.71336264
69DAPK10.71074465
70LMTK20.70869598
71PRKCH0.68880165
72CAMK1G0.68799452
73IRAK20.68654609
74MAP3K110.67580752
75BMPR1B0.67573824
76FGFR20.64231850
77BRAF0.63344326
78SGK4940.63106792
79SGK2230.63106792
80PRKD30.62937369
81CAMKK10.62519624
82RET0.59649893
83SGK20.59495833
84PRKCE0.57628632
85PRPF4B0.57318772
86PRKCZ0.57258956
87CSNK1G10.56681162
88MAP3K130.56248790
89TNK20.55302027
90CAMK10.54839935
91CAMK2G0.54117946
92RIPK40.52969045
93MKNK20.51495480
94CAMK2D0.51310063
95CSNK1A1L0.50935068
96STK110.49087510
97FGR0.49053177
98PRKG10.48401043
99PKN10.48031294
100MARK20.47432835
101CSNK1A10.47176486
102ROCK20.47117525
103DDR20.45680914
104RPS6KA20.44858413
105WNK40.44349524
106RAF10.42048370
107VRK10.42015710
108MAP3K20.41636212
109INSRR0.39915709
110ABL20.39400993
111RPS6KA30.39218039
112MAPKAPK50.38765376
113PRKAA10.38105066
114ERBB20.37652309
115PRKACB0.37619687
116SGK10.37553366
117PRKD20.36681567
118PRKACA0.35977689
119CSNK1D0.34360009
120MAP3K10.34074573
121MAPK90.33312857
122FYN0.32834882
123MAP2K10.32010555
124STK390.31953440
125ROCK10.31894990
126STK380.31361819
127PTK2B0.30838511
128CSNK1E0.30801299

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20507497
2Synaptic vesicle cycle_Homo sapiens_hsa047213.41707751
3GABAergic synapse_Homo sapiens_hsa047272.83105462
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63826512
5Oxidative phosphorylation_Homo sapiens_hsa001902.51172849
6Morphine addiction_Homo sapiens_hsa050322.38101713
7Steroid biosynthesis_Homo sapiens_hsa001002.27486876
8Circadian entrainment_Homo sapiens_hsa047132.27132230
9Collecting duct acid secretion_Homo sapiens_hsa049662.25982486
10Glutamatergic synapse_Homo sapiens_hsa047242.20832897
11Parkinsons disease_Homo sapiens_hsa050122.16505635
12Amphetamine addiction_Homo sapiens_hsa050312.16096088
13Dopaminergic synapse_Homo sapiens_hsa047282.16074462
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.14880615
15Olfactory transduction_Homo sapiens_hsa047402.11729520
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07388619
17Cocaine addiction_Homo sapiens_hsa050302.06369549
18Taste transduction_Homo sapiens_hsa047422.02836874
19Long-term potentiation_Homo sapiens_hsa047202.02728818
20Serotonergic synapse_Homo sapiens_hsa047261.99977523
21Insulin secretion_Homo sapiens_hsa049111.83082339
22Cardiac muscle contraction_Homo sapiens_hsa042601.80098719
23Alzheimers disease_Homo sapiens_hsa050101.76830682
24Vibrio cholerae infection_Homo sapiens_hsa051101.76624005
25Long-term depression_Homo sapiens_hsa047301.70326328
26Cholinergic synapse_Homo sapiens_hsa047251.70189967
27Salivary secretion_Homo sapiens_hsa049701.57176480
28Renin secretion_Homo sapiens_hsa049241.54791651
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53679394
30Axon guidance_Homo sapiens_hsa043601.53172612
31Gap junction_Homo sapiens_hsa045401.49143619
32Huntingtons disease_Homo sapiens_hsa050161.48885273
33Gastric acid secretion_Homo sapiens_hsa049711.41435598
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41433173
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41011025
36Basal cell carcinoma_Homo sapiens_hsa052171.40948909
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40679227
38Oxytocin signaling pathway_Homo sapiens_hsa049211.35722215
39Protein export_Homo sapiens_hsa030601.29327197
40GnRH signaling pathway_Homo sapiens_hsa049121.28949725
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28943083
42Calcium signaling pathway_Homo sapiens_hsa040201.24169901
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23796014
44Ribosome_Homo sapiens_hsa030101.15453410
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13286582
46Melanogenesis_Homo sapiens_hsa049161.08716789
47Estrogen signaling pathway_Homo sapiens_hsa049151.05831497
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03971828
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03841027
50Hippo signaling pathway_Homo sapiens_hsa043901.00659071
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00278581
52Phototransduction_Homo sapiens_hsa047440.97571795
53cAMP signaling pathway_Homo sapiens_hsa040240.92109079
54ErbB signaling pathway_Homo sapiens_hsa040120.90176735
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85870976
56Propanoate metabolism_Homo sapiens_hsa006400.85135527
57Oocyte meiosis_Homo sapiens_hsa041140.85114340
58Ether lipid metabolism_Homo sapiens_hsa005650.84604770
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83394785
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82356754
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.78997140
62Alcoholism_Homo sapiens_hsa050340.78808747
63Linoleic acid metabolism_Homo sapiens_hsa005910.77701963
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76169620
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.75664370
66Prion diseases_Homo sapiens_hsa050200.71578621
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70569762
68Dilated cardiomyopathy_Homo sapiens_hsa054140.70468645
69Type II diabetes mellitus_Homo sapiens_hsa049300.68929386
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66990377
71Glioma_Homo sapiens_hsa052140.66456261
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64338837
73beta-Alanine metabolism_Homo sapiens_hsa004100.64102392
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62938835
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62373586
76MAPK signaling pathway_Homo sapiens_hsa040100.61519514
77Thyroid hormone synthesis_Homo sapiens_hsa049180.61335850
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.61111346
79Wnt signaling pathway_Homo sapiens_hsa043100.60468619
80Regulation of autophagy_Homo sapiens_hsa041400.60285456
81Tryptophan metabolism_Homo sapiens_hsa003800.59600632
82Sulfur relay system_Homo sapiens_hsa041220.59095236
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58245088
84Peroxisome_Homo sapiens_hsa041460.56626382
85Fatty acid elongation_Homo sapiens_hsa000620.56133857
86Type I diabetes mellitus_Homo sapiens_hsa049400.55511570
87Hedgehog signaling pathway_Homo sapiens_hsa043400.55304972
88Dorso-ventral axis formation_Homo sapiens_hsa043200.54453220
89Protein digestion and absorption_Homo sapiens_hsa049740.53639976
90Phagosome_Homo sapiens_hsa041450.52754679
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.52156930
92Fatty acid metabolism_Homo sapiens_hsa012120.51435830
93Ras signaling pathway_Homo sapiens_hsa040140.51298670
94Renal cell carcinoma_Homo sapiens_hsa052110.50544303
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50306731
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49744594
97Choline metabolism in cancer_Homo sapiens_hsa052310.48934367
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48724666
99Pancreatic secretion_Homo sapiens_hsa049720.48420989
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48224740
101Butanoate metabolism_Homo sapiens_hsa006500.47483920
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47050889
103Selenocompound metabolism_Homo sapiens_hsa004500.46233815
104Rheumatoid arthritis_Homo sapiens_hsa053230.45805803
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45179764
106Fat digestion and absorption_Homo sapiens_hsa049750.44928516
107Tight junction_Homo sapiens_hsa045300.44884965
108Nitrogen metabolism_Homo sapiens_hsa009100.44691067
109Arginine and proline metabolism_Homo sapiens_hsa003300.42200910
110Glucagon signaling pathway_Homo sapiens_hsa049220.41731726
111Ovarian steroidogenesis_Homo sapiens_hsa049130.41627884
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41292276
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40960902
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40648419
115Bile secretion_Homo sapiens_hsa049760.39773929
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38586276
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.36977779
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36443704
119Folate biosynthesis_Homo sapiens_hsa007900.36077335
120Metabolic pathways_Homo sapiens_hsa011000.35669612
121Insulin signaling pathway_Homo sapiens_hsa049100.35622008
122Circadian rhythm_Homo sapiens_hsa047100.34626661
123Colorectal cancer_Homo sapiens_hsa052100.34575055
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33775287
125Endometrial cancer_Homo sapiens_hsa052130.33240106
126VEGF signaling pathway_Homo sapiens_hsa043700.32559379
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30941921
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27906849
129Rap1 signaling pathway_Homo sapiens_hsa040150.27522992
130Endocytosis_Homo sapiens_hsa041440.25545981
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22647611
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22068963
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21107280
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20014134

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